Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	mediator complex	MED23 THRAP3 MED13	4.46e-05	37	39	3	GO:0016592
GeneOntologyCellularComponent	nuclear protein-containing complex	DDX46 RERE MED23 TAF1L CDK13 THRAP3 MED13 XRCC6 STAT4 YY2	1.62e-04	1377	39	10	GO:0140513
GeneOntologyCellularComponent	nuclear cyclin-dependent protein kinase holoenzyme complex	CDK13 MED13	5.09e-04	18	39	2	GO:0019908
GeneOntologyCellularComponent	transcription regulator complex	SOX5 MED23 TAF1L XRCC6 STAT4 YY2	7.67e-04	596	39	6	GO:0005667
GeneOntologyCellularComponent	ficolin-1-rich granule lumen	EEF2 CDK13 XRCC6	1.59e-03	124	39	3	GO:1904813
Domain	GST_C	EPRS1 GSTO1	1.34e-03	26	39	2	IPR004046
Domain	GST_C	EPRS1 GSTO1	1.34e-03	26	39	2	PF00043
Domain	Glutathione-S-Trfase_C-like	EPRS1 GSTO1	3.00e-03	39	39	2	IPR010987
Domain	-	EPRS1 GSTO1	3.00e-03	39	39	2	1.20.1050.10
Domain	HMG_box	SOX5 SOX11	5.47e-03	53	39	2	PF00505
Domain	HMG_BOX_2	SOX5 SOX11	5.68e-03	54	39	2	PS50118
Domain	HMG	SOX5 SOX11	5.68e-03	54	39	2	SM00398
Domain	-	SOX5 SOX11	5.88e-03	55	39	2	1.10.30.10
Domain	HMG_box_dom	SOX5 SOX11	8.13e-03	65	39	2	IPR009071
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	UNK EPRS1 EEF2 DDX46 RERE MARK2 RBBP6 CDK13 THRAP3 MED13 XRCC6 RRP12	3.06e-11	774	39	12	15302935
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	EPRS1 EEF2 DDX46 RERE RBBP6 CDK13 THRAP3 XRCC6 RRP12	3.61e-08	655	39	9	35819319
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	EPRS1 EEF2 DDX46 MARK2 RBBP6 CDK13 THRAP3 USP6NL XRCC6 RRP12	6.77e-08	949	39	10	36574265
Pubmed	Human transcription factor protein interaction networks.	SOX5 UNK MRPS18C RERE HSPA4L TAF1L RBBP6 XRCC6 STAT4 RRP12 YY2	3.14e-07	1429	39	11	35140242
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	UNK MRPS18C DDX46 MARK2 MED23 TAF1L RBBP6 CDK13 USP6NL MED13 RRP12	4.99e-07	1497	39	11	31527615
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	EPRS1 EEF2 MARK2 HSPA4L RBBP6 THRAP3	5.94e-07	274	39	6	34244482
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	EEF2 MARK2 HSPA4L RBBP6 CDK13 THRAP3 XRCC6 RRP12	7.22e-07	678	39	8	30209976
Pubmed	The protein interaction landscape of the human CMGC kinase group.	MASP1 EEF2 DDX46 MED23 RBBP6 CDK13 THRAP3 MED13	8.70e-07	695	39	8	23602568
Pubmed	Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.	MED23 THRAP3 MED13	8.77e-07	17	39	3	10235266
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	EPRS1 EEF2 MARK2 RBBP6 CDK13 THRAP3 RRP12	1.31e-06	503	39	7	16964243
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	EEF2 DDX46 MED23 UHRF2 RBBP6 CDK13 THRAP3 MED13 XRCC6	1.42e-06	1014	39	9	32416067
Pubmed	Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.	MED23 THRAP3 MED13	1.47e-06	20	39	3	15340084
Pubmed	The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro.	MED23 THRAP3 MED13	1.98e-06	22	39	3	11867769
Pubmed	Composite co-activator ARC mediates chromatin-directed transcriptional activation.	MED23 THRAP3 MED13	2.27e-06	23	39	3	10235267
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	UNK EEF2 DDX46 RBBP6 CDK13 THRAP3 XRCC6 RRP12	2.64e-06	807	39	8	22681889
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	DDX46 RERE MED23 THRAP3 XRCC6	4.68e-06	220	39	5	35785414
Pubmed	Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.	EPRS1 EEF2 KCTD19 THRAP3 XRCC6 RRP12	7.06e-06	421	39	6	34650049
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	EPRS1 EEF2 DDX46 TAF1L RBBP6 THRAP3 XRCC6 YY2	9.00e-06	954	39	8	36373674
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	EEF2 DDX46 MED23 GSTO1 RRP12	1.09e-05	262	39	5	36880596
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	EPRS1 EEF2 DDX46 GSTO1 HSPA4L RBBP6 THRAP3 XRCC6 RRP12	1.19e-05	1318	39	9	30463901
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	EPRS1 EEF2 DDX46 RBBP6 THRAP3 XRCC6 RRP12	1.51e-05	731	39	7	29298432
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	DDX46 TAF1L RBBP6 THRAP3 XRCC6	1.58e-05	283	39	5	30585729
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	DDX46 MARK2 MED23 RBBP6 CDK13 XRCC6 RRP12	1.92e-05	759	39	7	35915203
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	EPRS1 EEF2 DDX46 RBBP6 CDK13 THRAP3	2.00e-05	506	39	6	30890647
Pubmed	Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.	EPRS1 EEF2 XRCC6 RRP12	2.07e-05	144	39	4	35681168
Pubmed	The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development.	THRAP3 MED13	2.56e-05	7	39	2	12093747
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	EPRS1 DDX46 THRAP3 XRCC6	2.69e-05	154	39	4	16055720
Pubmed	A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis.	HEMGN MED23	3.42e-05	8	39	2	27579896
Pubmed	Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator.	MED23 XRCC6	3.42e-05	8	39	2	10823961
Pubmed	A class of circadian long non-coding RNAs mark enhancers modulating long-range circadian gene regulation.	RERE ERRFI1	3.42e-05	8	39	2	28335007
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	EPRS1 EEF2 DDX46 ALDH9A1 GSTO1 HSPA4L XRCC6 RRP12	3.42e-05	1149	39	8	35446349
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	EPRS1 MRPS18C EEF2 DDX46 HSPA4L CDK13 THRAP3 XRCC6	3.51e-05	1153	39	8	29845934
Pubmed	Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators.	SOX5 SOX11	4.39e-05	9	39	2	12100890
Pubmed	Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.	THRAP3 MED13	4.39e-05	9	39	2	8710870
Pubmed	DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.	AKT3 XRCC6	4.39e-05	9	39	2	15678105
Pubmed	DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.	EPRS1 EEF2 ALDH9A1 XRCC6	4.44e-05	175	39	4	25756610
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	EEF2 RERE MED23 RBBP6 THRAP3 USP6NL RRP12 YY2	4.74e-05	1203	39	8	29180619
Pubmed	Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine Reader.	UHRF2 XRCC6	5.48e-05	10	39	2	27129234
Pubmed	A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression.	THRAP3 MED13	5.48e-05	10	39	2	12218053
Pubmed	From head to toes: the multiple facets of Sox proteins.	SOX5 SOX11	5.48e-05	10	39	2	10037800
Pubmed	HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.	MED23 MED13	5.48e-05	10	39	2	23746844
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	EPRS1 EEF2 MARK2 HSPA4L RBBP6 THRAP3 MED13 XRCC6	6.10e-05	1247	39	8	27684187
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	EPRS1 EEF2 MARK2 UHRF2 RBBP6 THRAP3 XRCC6 RRP12	6.45e-05	1257	39	8	36526897
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	EPRS1 EEF2 THRAP3 RRP12	7.75e-05	202	39	4	24639526
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	EPRS1 DDX46 TAF1L RBBP6 CDK13 THRAP3 XRCC6 RRP12	7.90e-05	1294	39	8	30804502
Pubmed	Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators.	SOX5 SOX11	8.03e-05	12	39	2	11071752
Pubmed	Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3.	SOX5 SOX11	8.03e-05	12	39	2	7590241
Pubmed	Mediator requirement for both recruitment and postrecruitment steps in transcription initiation.	EEF2 MED23	8.03e-05	12	39	2	15749018
Pubmed	Inactivation of insulin-like factor 6 disrupts the progression of spermatogenesis at late meiotic prophase.	EEF2 HSPA4L	8.03e-05	12	39	2	19520787
Pubmed	A novel docking site on Mediator is critical for activation by VP16 in mammalian cells.	MED23 MED13	9.48e-05	13	39	2	14657022
Pubmed	CDK8 is a positive regulator of transcriptional elongation within the serum response network.	MED23 MED13	9.48e-05	13	39	2	20098423
Pubmed	Seven new members of the Sox gene family expressed during mouse development.	SOX5 SOX11	9.48e-05	13	39	2	8441686
Pubmed	Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.	SOX5 SOX11	9.48e-05	13	39	2	12194848
Pubmed	MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.	MED23 MED13	9.48e-05	13	39	2	27570068
Pubmed	Cis-regulatory control of corticospinal system development and evolution.	SOX5 SOX11	9.48e-05	13	39	2	22678282
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	MRPS18C ALDH9A1 HSPA4L CDK13 THRAP3 XRCC6	9.49e-05	670	39	6	22990118
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	EPRS1 EEF2 HSPA4L THRAP3	1.10e-04	221	39	4	29991511
Pubmed	Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth.	SOX5 SOX11	1.11e-04	14	39	2	8921394
Pubmed	Structure, function, and activator-induced conformations of the CRSP coactivator.	MED23 MED13	1.11e-04	14	39	2	11834832
Pubmed	UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1.	UHRF2 XRCC6	1.11e-04	14	39	2	34111398
Pubmed	FOXG1 sequentially orchestrates subtype specification of postmitotic cortical projection neurons.	SOX5 SOX11	1.11e-04	14	39	2	35613274
Pubmed	FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.	EPRS1 EEF2 HSPA4L XRCC6	1.15e-04	224	39	4	28443643
Pubmed	Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.	EPRS1 EEF2 XRCC6	1.17e-04	84	39	3	19135240
Pubmed	Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.	MED23 MED13	1.27e-04	15	39	2	18418385
Pubmed	Differential isoform expression and alternative splicing in sex determination in mice.	SOX5 SOX11	1.27e-04	15	39	2	30871468
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	EPRS1 EEF2 MARK2 HSPA4L USP6NL XRCC6	1.28e-04	708	39	6	39231216
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	EPRS1 DDX46 THRAP3 XRCC6	1.39e-04	235	39	4	30258100
Pubmed	Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.	EPRS1 EEF2 HSPA4L THRAP3	1.41e-04	236	39	4	36339263
Pubmed	Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development.	EEF2 GSTO1 XRCC6	1.43e-04	90	39	3	28978906
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	EPRS1 EEF2 DDX46 HSPA4L	1.43e-04	237	39	4	29564676
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	MRPS18C EEF2 RBBP6 CDK13 THRAP3 XRCC6	1.44e-04	723	39	6	34133714
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	EPRS1 EEF2 DDX46 HSPA4L CDK13 THRAP3 XRCC6 RRP12	1.47e-04	1415	39	8	28515276
Pubmed	The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells.	EPRS1 EEF2 THRAP3 XRCC6	1.48e-04	239	39	4	26641092
Pubmed	Spatio-temporal expression of Sox genes in murine palatogenesis.	SOX5 SOX11	1.65e-04	17	39	2	27241892
Pubmed	Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.	SOX5 STAT4	1.65e-04	17	39	2	21779181
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	MRPS18C AKT3 EEF2 DDX46 HSPA4L THRAP3 XRCC6 RRP12	1.66e-04	1440	39	8	30833792
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	EEF2 DDX46 MED23 RBBP6 THRAP3 XRCC6 RRP12	1.78e-04	1082	39	7	38697112
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	UNK EEF2 GRIK2 DDX46 HSPA4L	1.83e-04	475	39	5	31040226
Pubmed	Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.	THRAP3 MED13	1.85e-04	18	39	2	10198638
Pubmed	Expression of Sox genes in tooth development.	SOX5 SOX11	1.85e-04	18	39	2	26864488
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	EEF2 MARK2 CDK13 XRCC6 RRP12	1.97e-04	483	39	5	36912080
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	EPRS1 EEF2 MED23 UHRF2 CDK13 THRAP3 XRCC6	2.00e-04	1103	39	7	34189442
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	EEF2 DDX46 THRAP3 XRCC6 RRP12	2.03e-04	486	39	5	30940648
Pubmed	An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.	MED23 MED13	2.07e-04	19	39	2	16799563
Pubmed	Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.	MED23 THRAP3	2.07e-04	19	39	2	16204234
Pubmed	KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.	EPRS1 EEF2 XRCC6	2.20e-04	104	39	3	36055981
Pubmed	ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.	MARK2 MED23 MED13	2.39e-04	107	39	3	20508642
Pubmed	Expression of Sox transcription factors in the developing mouse pancreas.	SOX5 SOX11	2.54e-04	21	39	2	12815626
Pubmed	The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways.	SOX5 SOX11	2.54e-04	21	39	2	27600842
Pubmed	The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.	SOX5 SOX11	2.54e-04	21	39	2	16306355
Pubmed	Physiological and pathophysiological characteristics of ataxin-3 isoforms.	EPRS1 EEF2 HSPA4L XRCC6	2.75e-04	281	39	4	30455355
Pubmed	SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function.	SOX5 SOX11	2.79e-04	22	39	2	17084361
Pubmed	A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.	EPRS1 EEF2 THRAP3 XRCC6	2.94e-04	286	39	4	32041737
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	UNK DDX46 MED23 USP6NL MED13	3.00e-04	529	39	5	14621295
Pubmed	DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex.	SOX5 SOX11	3.05e-04	23	39	2	30329130
Pubmed	A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells.	DDX46 THRAP3 XRCC6	3.43e-04	121	39	3	22412018
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	EPRS1 DDX46 MED23 RBBP6 THRAP3	3.56e-04	549	39	5	38280479
Pubmed	A cluster of three long-range enhancers directs regional Shh expression in the epithelial linings.	SOX5 SOX11	3.62e-04	25	39	2	19369396
Pubmed	Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network.	MED23 MED13	3.91e-04	26	39	2	34506481
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	EPRS1 EEF2 ALDH9A1 HSPA4L CDK13 XRCC6	4.08e-04	878	39	6	37223481
Interaction	RC3H2 interactions	UNK EEF2 MARK2 HSPA4L RBBP6 CDK13 THRAP3 XRCC6 RRP12	3.93e-06	667	39	9	int:RC3H2
Interaction	RNF113A interactions	EPRS1 EEF2 DDX46 RERE RBBP6 CDK13 THRAP3 XRCC6 RRP12	5.30e-06	692	39	9	int:RNF113A
Interaction	MYCN interactions	FOXR1 EPRS1 MRPS18C EEF2 DDX46 MARK2 HSPA4L RBBP6 CDK13 THRAP3 XRCC6 RRP12	6.63e-06	1373	39	12	int:MYCN
Interaction	HECTD1 interactions	EPRS1 EEF2 DDX46 MARK2 MED23 HSPA4L RBBP6 CDK13 XRCC6 RRP12	1.28e-05	984	39	10	int:HECTD1
Interaction	TNIP1 interactions	UNK EPRS1 EEF2 DDX46 MARK2 RBBP6 CDK13 THRAP3 USP6NL XRCC6 RRP12	1.30e-05	1217	39	11	int:TNIP1
Interaction	HAPSTR1 interactions	UNK EPRS1 EEF2 RERE MARK2 HSPA4L RBBP6 XRCC6 RRP12	2.25e-05	829	39	9	int:HAPSTR1
Interaction	ZNF608 interactions	SOX5 EPRS1 RERE MED23	3.09e-05	93	39	4	int:ZNF608
Interaction	GLDC interactions	EPRS1 EEF2 MARK2 HSPA4L RBBP6 THRAP3	3.26e-05	321	39	6	int:GLDC
Interaction	SOX11 interactions	SOX5 SOX11	1.01e-04	8	39	2	int:SOX11
Interaction	ESRRB interactions	MED23 MED13 XRCC6 RRP12 ERRFI1	1.43e-04	262	39	5	int:ESRRB
GeneFamily	SRY-boxes	SOX5 SOX11	3.89e-04	19	28	2	757
GeneFamily	Cyclins\|Mediator complex	MED23 MED13	1.19e-03	33	28	2	1061
Coexpression	LI_WILMS_TUMOR_ANAPLASTIC_DN	RBBP6 STAT4	2.15e-05	5	39	2	M1216
Coexpression	MARTINEZ_RB1_AND_TP53_TARGETS_DN	SOX5 SOX11 EPRS1 MASP1 RBBP6 THRAP3 ERRFI1	2.88e-05	610	39	7	M3854
Coexpression	MARTINEZ_RB1_AND_TP53_TARGETS_DN	SOX5 SOX11 EPRS1 MASP1 RBBP6 THRAP3 ERRFI1	4.31e-05	650	39	7	MM1042
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_500_k-means-cluster#4	SOX5 ZFHX2 GRIK2 HSPA4L	2.22e-05	90	39	4	Facebase_RNAseq_e8.5_Floor Plate_500_K4
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000_k-means-cluster#3	SOX5 ZFHX2 SOX11 AKT3 GRIK2 SPATA6	3.31e-05	339	39	6	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_2500_k-means-cluster#5	ZFHX2 SOX11 GRIK2 SPATA6 HSPA4L USP6NL	3.96e-05	350	39	6	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_2500_K5
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_500_k-means-cluster#3	ZFHX2 SOX11 AKT3 GRIK2	6.41e-05	118	39	4	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_500_K3
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_1000_k-means-cluster#2	SOX5 ZFHX2 GRIK2 HSPA4L	7.30e-05	122	39	4	Facebase_RNAseq_e8.5_Floor Plate_1000_K2
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_2500_k-means-cluster#3	SOX5 ZFHX2 SOX11 AKT3 GRIK2 DDX46 SPATA6 HSPA4L	1.83e-04	893	39	8	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_500	SOX5 ZFHX2 SOX11 AKT3 GRIK2 HSPA4L	2.67e-04	496	39	6	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000	SOX5 ZFHX2 SOX11 AKT3 GRIK2 DDX46 SPATA6 HSPA4L	3.58e-04	986	39	8	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000	ZFHX2 SOX11 EPRS1 MASP1 GRIK2 DDX46 HSPA4L RBBP6	3.65e-04	989	39	8	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
ToppCell	(2)_Fibroblasts-(21)_Fibro-2\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	ADAMTS16 SOX5 ZFHX2 SOX11 ERRFI1	6.53e-07	190	39	5	d2afa08ad868acc6fce308ec21b0bf93591d4010
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	AKT3 MED23 UHRF2 CDK13 STAT4	7.80e-07	197	39	5	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	10x3'2.3-week_12-13-Mesenchymal_fibro-stroma-endosteal_fibroblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ADAMTS16 SOX5 MASP1 ERRFI1	2.21e-05	189	39	4	c392491aabe8a3e90974ab2ea123bbbe5200439d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS16 SOX5 AKT3 GRIK2	2.26e-05	190	39	4	b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SOX5 SOX11 RERE SPATA6	2.45e-05	194	39	4	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_OPC-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SOX11 EEF2 HSPA4L ERRFI1	2.60e-05	197	39	4	d9a5b6171867de21d4ef12aa5a802fb4de9e0c00
Disease	unipolar depression, bipolar disorder	SOX5 GRIK2 RERE MARK2	3.46e-05	156	35	4	EFO_0003761, MONDO_0004985
Disease	Glioblastoma Multiforme	AKT3 GRIK2 TAF1L	3.11e-04	111	35	3	C1621958
Disease	sleep measurement	NDST3 SOX5 CFAP44	5.51e-04	135	35	3	EFO_0004870
Disease	Malignant neoplasm of salivary gland	SOX11 MARK2	1.31e-03	45	35	2	C0220636
Disease	Salivary Gland Neoplasms	SOX11 MARK2	1.43e-03	47	35	2	C0036095
Disease	schizophrenia, anorexia nervosa	AKT3 RERE	1.49e-03	48	35	2	MONDO_0005090, MONDO_0005351
Disease	obesity (implicated_via_orthology)	ZFHX2 MED13 STAT4	2.10e-03	215	35	3	DOID:9970 (implicated_via_orthology)
Disease	hearing threshold measurement, hearing measurement	SOX5 ALDH9A1	2.39e-03	61	35	2	EFO_0007616, EFO_0007618
Disease	physical activity measurement	SOX5 AKT3 RERE	3.04e-03	245	35	3	EFO_0008002
Disease	susceptibility to strep throat measurement	CDK13 ERRFI1	3.69e-03	76	35	2	EFO_0008408
Disease	asthma, allergic disease	RERE UHRF2	3.98e-03	79	35	2	MONDO_0004979, MONDO_0005271
Disease	systemic scleroderma	SOX5 STAT4	4.59e-03	85	35	2	EFO_0000717
Disease	cortical surface area measurement	SOX5 SOX11 AKT3 RERE MED23 XRCC6	4.62e-03	1345	35	6	EFO_0010736

Protein segments in the cluster

Peptide	Gene	Start	Entry
VPEDPKLKDGYYMRP	ALDH9A1	361	P49189
SKEPPSAYKEPPKAY	CDK13	286	Q14004
PPKAYREDKTEPKAY	CDK13	296	Q14004
LYKSKPGDDYEDPKD	CFAP44	1146	Q96MT7
LADQPKPVKEYKYPE	ADAMTS16	491	Q8TE57
KPVKEYKYPEKLPGE	ADAMTS16	496	Q8TE57
IGYKEKPQDVDLPYP	AKT3	36	Q9Y243
YKEYPGGPKELDKSI	NDST3	486	O95803
GAKDKGPEPTFKPYL	KCTD19	706	Q17RG1
DPAIPLLGIYPKDYK	nan	1171	O00370
EYLDEAYPGKKLLPD	GSTO1	91	P78417
AYPGKKLLPDDPYEK	GSTO1	96	P78417
PLKGLLPYDKDLFEP	MED23	251	Q9ULK4
YPKPDVPKGYILDTD	HEMGN	261	Q9BXL5
EAYAIGKKEKPPFLP	RBBP6	226	Q7Z6E9
LEKKPNPDKDGPDYE	FOXR1	36	Q6PIV2
DELKPYVEPLPDYKD	MARK2	311	Q7KZI7
PCPYDYIKIKVGPKV	MASP1	241	P48740
GPNYTPGKKEDLYLK	EEF2	431	P13639
TYFPPGKEPKEGERK	DDX46	971	Q7L014
EPYVLFKKSDKPLYG	GRIK2	441	Q13002
ADYPDYKYRPRKKPK	SOX11	111	P35716
YKEKTGQEYKPGNPP	EPRS1	791	P07814
NYYKRKPGKDPGAPD	TAF1L	721	Q8IZX4
FKKYGELPPIEKPVD	RERE	536	Q9P2R6
PKPSEIKDFSYVYKP	MED13	891	Q9UHV7
LLPERPPYLDKYEKF	ERRFI1	396	Q9UJM3
PVTYKDPAYLKDPKV	MRPS18C	121	Q9Y3D5
DVKKKGRPDPYAYIP	RRP12	1241	Q5JTH9
QYPAGYPSDKEGKKP	UHRF2	636	Q96PU4
KELVYPPDYNPEGKV	XRCC6	526	P12956
LPEPGKEDEYPKKPL	USP6NL	356	Q92738
EPGYKAEGKYKDDPV	THRAP3	701	Q9Y2W1
KSYDSLYPPLAEPPK	ZFHX2	1521	Q9C0A1
YGIYKQDLPPLDEKP	HSPA4L	181	O95757
NPLKYLYPDIPKDKA	STAT4	656	Q14765
NPPDYSEYLKGKKLP	YY2	206	O15391
YPDLELKYGPEKVSP	ZNF780A	76	O75290
YPDLESKYGPEKISP	ZNF780B	76	Q9Y6R6
GYEDEKKNEKPPKPS	VSTM1	16	Q6UX27
HLEKYPDYKYKPRPK	SOX5	616	P35711
YVLGNYKTEPCKKPP	UNK	211	Q9C0B0
NLGPYEFKKETDKPP	SPATA6	241	Q9NWH7