Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	NUMBL TACC2 SRCAP WNK1 PDLIM5 GSR ALMS1 GLO1 GLUD1 SEC16A MACF1 PRPF19 RPRD2 BOD1L1 EIF4G3 CAMSAP1 SON RAD21	1.21e-08	934	129	18	33916271
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TRERF1 NUMBL NTRK2 WDR81 SBF1 TMEM259 SPHKAP NCAN SEC16A PPP1R3F MACF1 ADGRA1 HERC2 CAMSAP1 CABIN1 CDH11 WNK2 KDM1A	1.92e-08	963	129	18	28671696
Pubmed	Human transcription factor protein interaction networks.	TRERF1 RRP1B DIS3L SSBP2 SMG5 RREB1 SRCAP HMG20A KANSL3 ALMS1 GLO1 ZNF451 GLUD1 SEC16A PRPF19 RPRD2 HERC2 CABIN1 RPA2 KDM1A RAD21	7.08e-08	1429	129	21	35140242
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	SRCAP ARHGEF17 WNK1 ALMS1 SEC16A HERC2 CABIN1	1.29e-07	104	129	7	9205841
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SZT2 TSNARE1 SMG5 SRCAP SPPL2B WNK1 RYR1 KANSL3 SBF1 SH3TC1 TMEM259 SCN5A SEC16A HERC2 CAMSAP1 CABIN1 WNK2 TJP3	1.51e-07	1105	129	18	35748872
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	RRP1B NCBP1 RREB1 SRCAP HMG20A SBNO1 ZNF451 BRPF1 BOD1L1 HERC2 CABIN1 KDM1A RAD21	4.64e-07	608	129	13	36089195
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NUMBL PLEKHG2 ARHGEF17 WNK1 RBSN ALMS1 SBF1 RABGAP1L SEC16A MACF1 BOD1L1 TAB1 GNAS EIF4G3 CAMSAP1	7.77e-07	861	129	15	36931259
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	MZB1 PARP10 MVB12A ALMS1 NYNRIN PPP1R3F HSF1 WNK2	2.73e-06	233	129	8	37704626
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RRP1B SZT2 JADE2 SMG5 KANSL3 SBF1 ARHGAP31 RPRD2 WNK2 KDM1A RAD21	4.81e-06	529	129	11	14621295
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	USB1 SZT2 NTRK2 MUC16 PDLIM5 RYR1 ZFHX2 GNAS HERC2 EIF4G3 FHIP1A	7.18e-06	552	129	11	10737800
Pubmed	Regulation of LSD1 histone demethylase activity by its associated factors.	RREB1 HMG20A KDM1A	1.07e-05	12	129	3	16140033
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	TACC2 SRCAP WNK1 GSR KANSL3 ALMS1 ZNF451 SEC16A MACF1 GNAS KDM1A	1.29e-05	588	129	11	38580884
Pubmed	A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly.	KIAA1586 ZNF451	1.37e-05	2	129	2	26524493
Pubmed	Heterotrimeric G protein Gαs subunit attenuates PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, by direct interaction.	PLEKHG2 GNAS	1.37e-05	2	129	2	28108261
Pubmed	Expression of tyrosine kinase receptor B in eutopic endometrium of women with adenomyosis.	NTRK2 MUC16	1.37e-05	2	129	2	21079983
Pubmed	Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice.	GSR GLO1	1.37e-05	2	129	2	16244648
Pubmed	WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia.	WNK1 WNK2	1.37e-05	2	129	2	35849656
Pubmed	Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PLEKHG4 WDR81 PLEKHG2 SH3TC1 TMEM259	1.68e-05	85	129	5	15449545
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	DIS3L PKD1L1 PLEKHG2 PDLIM5 RBSN MVB12A ALMS1 BRPF1 TAB1 HERC2 TBC1D23 CAMSAP1 FHIP1A	1.83e-05	853	129	13	28718761
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	WNK1 PDLIM5 SEC16A PRPF19 RPRD2 BOD1L1 PSPC1 RPA2 SON	1.92e-05	399	129	9	35987950
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ADAM19 DIS3L JADE2 NCBP1 SMG5 SLC4A3 PDLIM5 HMG20A SBNO1 ZNF451 GLUD1 MACF1 HERC2 TBC1D23 EIF4G3 CABIN1	2.32e-05	1285	129	16	35914814
Pubmed	Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.	TRERF1 RREB1 HMG20A KDM1A	2.39e-05	45	129	4	21258344
Pubmed	RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.	PRPF19 HERC2 RPA2	2.69e-05	16	129	3	26474068
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TRERF1 WNK1 ARHGAP31 EIF4G3 CAMSAP1 NYAP1 FHIP1A WNK2 SON	3.44e-05	430	129	9	35044719
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	NUMBL JADE2 TSNARE1 ZNF385A RBBP8NL SPPL2B ATP10A KANSL3 PARP10 SH3TC1 ZFHX2 MACF1 RPRD2 BOD1L1 GNAS EIF4G3 WNK2	3.78e-05	1489	129	17	28611215
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	PLEKHG4 PLEKHG2 ARHGEF17 ARHGAP31 GLO1 BRPF1 GLUD1 SEC16A ARHGAP28 TAB1 PSPC1 KDM1A FGD3	3.82e-05	916	129	13	32203420
Pubmed	Novel role of RGS2 in regulation of antioxidant homeostasis in neuronal cells.	GSR GLO1	4.09e-05	3	129	2	21510939
Pubmed	Gene trapping of two novel genes, Hzf and Hhl, expressed in hematopoietic cells.	ZNF385A RABGAP1L	4.09e-05	3	129	2	10585558
Pubmed	HERC2 regulates RPA2 by mediating ATR-induced Ser33 phosphorylation and ubiquitin-dependent degradation.	HERC2 RPA2	4.09e-05	3	129	2	31582797
Pubmed	Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development.	JADE2 KDM1A	4.09e-05	3	129	2	25018020
Pubmed	Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling.	WNK1 WNK2	4.09e-05	3	129	2	23797875
Pubmed	Specific activation of PLEKHG2-induced serum response element-dependent gene transcription by four-and-a-half LIM domains (FHL) 1, but not FHL2 or FHL3.	PLEKHG2 GNAS	4.09e-05	3	129	2	28489964
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	RRP1B SRCAP SBF1 SEC16A RPRD2 HERC2 CAMSAP1 RPA2 KDM1A	4.11e-05	440	129	9	34244565
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	NUMBL TACC2 KANSL3 SBNO1 GLO1 ZNF451 SEC16A TAB1 HSF1	4.41e-05	444	129	9	34795231
Pubmed	Global proteomics of Ubqln2-based murine models of ALS.	SMG5 RYR1 MVB12A NYNRIN GLO1 TAB1 RPA2	5.68e-05	261	129	7	33277362
Pubmed	Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.	SZT2 RABGAP1L MACF1 RPRD2	5.71e-05	56	129	4	9455484
Pubmed	Protein phosphatase 1γ isoforms linked interactions in the brain.	RRP1B TACC2 CSRNP1 RPRD2	6.13e-05	57	129	4	23080069
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	DIS3L RREB1 SRCAP HMG20A HMCN2 ALMS1 SH3TC1 BRPF1 SCN5A SEC16A ZNF324 MACF1 KDM1A SON	7.18e-05	1116	129	14	31753913
Pubmed	Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase.	HERC2 RPA2	8.15e-05	4	129	2	20304803
Pubmed	Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed.	WNK1 WNK2	8.15e-05	4	129	2	34384519
Pubmed	WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.	WNK1 WNK2	8.15e-05	4	129	2	11571656
Pubmed	Human hypertension caused by mutations in WNK kinases.	WNK1 WNK2	8.15e-05	4	129	2	11498583
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	RRP1B NCBP1 SRCAP GLO1 GLUD1 SEC16A MACF1 PRPF19 GNAS HERC2 PSPC1 KDM1A SON	1.17e-04	1024	129	13	24711643
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	TACC2 SBNO1 PRPF19 RPRD2 SON	1.28e-04	130	129	5	35545047
Pubmed	Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.	HMG20A SEC16A PRPF19 PSPC1 KDM1A	1.33e-04	131	129	5	34551306
Pubmed	The PSO4 protein complex associates with replication protein A (RPA) and modulates the activation of ataxia telangiectasia-mutated and Rad3-related (ATR).	PRPF19 RPA2	1.36e-04	5	129	2	24443570
Pubmed	Control of neuronal differentiation by sumoylation of BRAF35, a subunit of the LSD1-CoREST histone demethylase complex.	HMG20A KDM1A	1.36e-04	5	129	2	22570500
Pubmed	Targeting of cadherin-11 decreases skin fibrosis in the tight skin-1 mouse model.	BLOC1S6 CDH11	1.36e-04	5	129	2	29112946
Pubmed	A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination.	PRPF19 RPA2	1.36e-04	5	129	2	28666352
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ARHGEF17 ZNF451 SPHKAP RABGAP1L SEC16A MACF1 BOD1L1 SON	1.46e-04	407	129	8	12693553
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RRP1B NCBP1 SBF1 SEC16A MACF1 HERC2 EIF4G3 KDM1A SON RAD21	1.69e-04	653	129	10	22586326
Pubmed	Control of developmentally primed erythroid genes by combinatorial co-repressor actions.	SSBP2 HMG20A KDM1A	1.88e-04	30	129	3	26593974
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	RRP1B NUMBL NCBP1 SSBP2 SRCAP ZC3H6 HMG20A SBF1 ZNF324 MACF1 PRPF19 PSPC1 SON	2.01e-04	1082	129	13	38697112
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SMG5 WNK1 ALMS1 SEC16A MACF1 RPRD2	2.01e-04	225	129	6	12168954
Pubmed	Mpn1, mutated in poikiloderma with neutropenia protein 1, is a conserved 3'-to-5' RNA exonuclease processing U6 small nuclear RNA.	USB1 PRPF19	2.03e-04	6	129	2	23022480
Pubmed	WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters.	WNK1 WNK2	2.03e-04	6	129	2	21733846
Pubmed	CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.	ALMS1 FGF21 GNAS HSF1 KDM1A	2.21e-04	146	129	5	29688375
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	RRP1B EIF2S3B RREB1 HMG20A ZNF451 SEC16A PRPF19 RPRD2 BOD1L1 PSPC1 SON RAD21	2.35e-04	954	129	12	36373674
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	RRP1B NCBP1 EIF2S3B TACC2 WNK1 GSR SBNO1 GLUD1 SEC16A MACF1 PRPF19 HSF1 PSPC1 SON RAD21	2.49e-04	1415	129	15	28515276
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	SBF1 BRPF1 SEC16A MACF1 CAMSAP1 SLC29A4 SON	2.51e-04	332	129	7	37433992
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	RBSN ZNF451 MACF1 KDM1A RAD21	2.58e-04	151	129	5	17043677
Pubmed	Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.	WNK1 WNK2	2.83e-04	7	129	2	20525693
Pubmed	HMG20A is required for SNAI1-mediated epithelial to mesenchymal transition.	HMG20A KDM1A	2.83e-04	7	129	2	25639869
Pubmed	Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization.	NUMBL NTRK2	2.83e-04	7	129	2	15598981
Pubmed	RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling.	SSBP2 RPA2	2.83e-04	7	129	2	25916848
Pubmed	Chromosomal localization of muscle nicotinic acetylcholine receptor genes in the mouse.	CHRND GLO1	2.83e-04	7	129	2	3022377
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	PDLIM5 ALMS1 SBNO1 GNAS EIF4G3 CAMSAP1	2.97e-04	242	129	6	34011540
Pubmed	Interaction network of human early embryonic transcription factors.	TRERF1 SSBP2 RREB1 ALMS1 GLUD1 SEC16A KDM1A	3.50e-04	351	129	7	38297188
Pubmed	KLHL2 interacts with and ubiquitinates WNK kinases.	WNK1 WNK2	3.77e-04	8	129	2	23838290
Pubmed	The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.	WNK1 WNK2	3.77e-04	8	129	2	23387299
Pubmed	Fine mapping of the friend retrovirus resistance gene, Rfv3, on mouse chromosome 15.	CSF2RB HSF1	3.77e-04	8	129	2	10438878
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	PLEKHG2 ARHGEF17 FGD3	3.82e-04	38	129	3	11756498
Pubmed	Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins.	RRP1B NCBP1 RPRD2	3.82e-04	38	129	3	23537643
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	RRP1B PKD1L1 ATP10A HMCN2 MACF1 CAMSAP1 SON	4.14e-04	361	129	7	26167880
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	RREB1 WNK1 PDLIM5 NBAS ALMS1 ZNF451 SEC16A RPRD2 BOD1L1 CAMSAP1	4.22e-04	733	129	10	34672954
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	COL15A1 RRP1B TACC2 NBAS ALMS1 GLO1 GLUD1 SEC16A TAB1 GNAS HERC2 PSPC1 RPA2 SON RAD21	4.48e-04	1496	129	15	32877691
Pubmed	A human MAP kinase interactome.	JADE2 WNK1 BLOC1S6 ARHGAP31 ZNF451 MACF1 HERC2 WNK2	4.79e-04	486	129	8	20936779
Pubmed	Transcriptome profile of subsynaptic myonuclei at the neuromuscular junction in embryogenesis.	DOK7 CHRND	4.83e-04	9	129	2	37994470
Pubmed	eIF4G is required for the pioneer round of translation in mammalian cells.	NCBP1 EIF4G3	4.83e-04	9	129	2	15361857
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	JADE2 NTRK2 TNFRSF10C RREB1 PARP10 GLO1 HERC2	4.88e-04	371	129	7	15747579
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	NUMBL DIS3L WDR81 NCBP1 WNK1 PDLIM5 MVB12A SEC16A RPRD2 TAB1 GNAS TJP3	5.01e-04	1038	129	12	26673895
Pubmed	UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination.	RRP1B EIF2S3B PRPF19 BOD1L1 TAB1 GNAS PSPC1 RPA2	5.12e-04	491	129	8	36273042
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	RREB1 HMG20A KANSL3 PSPC1 KDM1A	5.34e-04	177	129	5	26206133
Pubmed	NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.	PLEKHG2 ARHGEF17 FGD3	5.52e-04	43	129	3	12376548
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	RBSN GLO1 SEC16A MACF1 BOD1L1 EIF4G3 PSPC1 KDM1A	5.62e-04	498	129	8	36634849
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZNF451 SPHKAP ZFHX2 WNK2	5.80e-04	102	129	4	11214970
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	RRP1B TACC2 WNK1 RBSN SEC16A RPRD2 EIF4G3 SON	6.00e-04	503	129	8	16964243
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	ALMS1 ARHGAP31 SEC16A RPRD2 CAMSAP1	6.36e-04	184	129	5	32908313
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	NCBP1 SRCAP WNK1 PDLIM5 ALMS1 SEC16A CAMSAP1 CABIN1 KDM1A	7.00e-04	645	129	9	25281560
Pubmed	The functional interactome landscape of the human histone deacetylase family.	TRERF1 RREB1 HMG20A SEC16A KDM1A SON	7.57e-04	289	129	6	23752268
Pubmed	Identification of HYPK-interacting proteins reveals involvement of HYPK in regulating cell growth, cell cycle, unfolded protein response and cell death.	GLUD1 HSF1 CDH11	8.60e-04	50	129	3	23272104
Pubmed	Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex.	RREB1 KDM1A	8.79e-04	12	129	2	17967884
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	WDR81 NCBP1 SRCAP RYR1 NBAS GLO1 BRPF1 MACF1 PRPF19 GNAS	8.82e-04	807	129	10	30575818
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	NUMBL EIF2S3B ARHGEF17 PDLIM5 SBF1 GLO1 NCAN GLUD1 SEC16A MACF1 PRPF19 EIF4G3 PSPC1 WNK2	8.87e-04	1431	129	14	37142655
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	TRERF1 ZNF385A SRCAP ZC3H6 PDLIM5 HMG20A ZNF451 BRPF1 ZNF324 HSF1	8.91e-04	808	129	10	20412781
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TRERF1 RREB1 RBBP8NL ALMS1 SEC16A CAMSAP1 KDM1A	9.80e-04	418	129	7	34709266
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SRCAP PDLIM5 ALMS1 SEC16A RPRD2 BOD1L1 TAB1 KDM1A	1.05e-03	549	129	8	38280479
Pubmed	Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.	ZNF385A SRCAP NBAS SEC16A	1.06e-03	120	129	4	21697133
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	ALMS1 MACF1 HERC2 KDM1A	1.06e-03	120	129	4	31413325
Pubmed	DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.	ARHGEF17 PDLIM5 SEC16A PPP1R3F	1.13e-03	122	129	4	30773093
Interaction	NAA40 interactions	NUMBL TACC2 SRCAP WNK1 PDLIM5 GSR ALMS1 GLO1 GLUD1 SEC16A MACF1 PRPF19 RPRD2 BOD1L1 EIF4G3 CAMSAP1 PSPC1 RPA2 SON RAD21	3.14e-06	978	127	20	int:NAA40
Cytoband	2q36	SLC4A3 SPHKAP	2.20e-04	8	130	2	2q36
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	THSD8 MUC16 SPPL2B ZNF414 MVB12A CLEC17A TMEM259 NCAN TJP3	4.67e-04	797	130	9	chr19p13
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG4 PLEKHG2 ARHGEF17 FGD3	1.54e-04	66	74	4	722
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	RRP1B WDR81 WNK1 RYR1 PPP1R3F	8.77e-04	181	74	5	694
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	ADAM19 TACC2 SLC4A3 PDLIM5 RABGAP1L SCN5A WNK2	1.36e-06	188	130	7	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	TACC2 SLC4A3 PDLIM5 SPHKAP RABGAP1L SCN5A WNK2	1.51e-06	191	130	7	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM19 COL15A1 ATP10A PDLIM5 HMCN2 CDH11 WNK2	1.80e-06	196	130	7	1522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM19 COL15A1 ATP10A PDLIM5 HMCN2 CDH11 WNK2	1.80e-06	196	130	7	1c8294014713684b50885e638668f2ce75f357f0
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D122\|Adult / Lineage, Cell type, age group and donor	PLSCR4 ADAM19 DCDC2C HID1 F8 NYAP1	1.19e-05	173	130	6	dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOK7 SLC4A3 SCN5A FHIP1A INPP5J WNK2	1.80e-05	186	130	6	337f768cc43db2db96ba6495b076006b1a5b0331
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOK7 SLC4A3 SCN5A FHIP1A INPP5J WNK2	1.80e-05	186	130	6	e378c82ef6d6cb24751515aa499a01372b3e7ccf
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	TACC2 SLC4A3 PDLIM5 SPHKAP SCN5A WNK2	2.02e-05	190	130	6	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	RA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	ADAM19 NTRK2 TACC2 PDLIM5 RABGAP1L WNK2	2.28e-05	194	130	6	89812fb164065041357bb37a3c2d87028ec3de4e
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	TACC2 PDLIM5 SPHKAP SCN5A FHIP1A WNK2	2.34e-05	195	130	6	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PLSCR4 ADAM19 COL15A1 ATP10A PDLIM5 CDH11	2.34e-05	195	130	6	49c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PLSCR4 ADAM19 COL15A1 ATP10A PDLIM5 CDH11	2.34e-05	195	130	6	dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCell	Control-Control-Lymphocyte-T/NK-NK_activated\|Control / Disease, condition lineage and cell class	VWCE FAM156A SEC16A MACF1 EIF4G3 MDGA1	2.55e-05	198	130	6	76d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
Drug	Xylazine [7361-61-7]; Up 200; 18.2uM; PC3; HT_HG-U133A	NTRK2 TNFRSF10C SPPL2B PDLIM5 CHRND KLHL11 SH3TC1 RABGAP1L HSF1	1.60e-06	196	127	9	4066_UP
Disease	event-related brain oscillation	KANSL3 GNAS	1.06e-04	4	125	2	EFO_0004358
Disease	Myasthenic Syndromes, Congenital	DOK7 CHRND VAMP1	1.41e-04	24	125	3	C0751882
Disease	MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE	RYR1 CHRND	2.64e-04	6	125	2	C1854678
Disease	pseudohypoaldosteronism (implicated_via_orthology)	WNK1 WNK2	2.64e-04	6	125	2	DOID:4479 (implicated_via_orthology)
Disease	central serous retinopathy	RBBP8NL WNK1	4.90e-04	8	125	2	EFO_0009784
Disease	Developmental delay (disorder)	SZT2 NBAS KDM1A	5.19e-04	37	125	3	C0424605
Disease	Pseudohypoaldosteronism, Type I	WNK1 GNAS	7.84e-04	10	125	2	C0268436
Disease	Pseudohypoaldosteronism	WNK1 GNAS	7.84e-04	10	125	2	C0033805
Disease	Hyperpotassemia and Hypertension, Familial	WNK1 GNAS	7.84e-04	10	125	2	C2713447
Disease	Pseudohypoaldosteronism, Type I, Autosomal Recessive	WNK1 GNAS	7.84e-04	10	125	2	C1449843
Disease	Pseudohypoaldosteronism, Type II	WNK1 GNAS	7.84e-04	10	125	2	C1449844
Disease	Pseudohypoaldosteronism, Type I, Autosomal Dominant	WNK1 GNAS	7.84e-04	10	125	2	C1449842
Disease	Cardiomyopathy, Dilated	CSRNP1 ALMS1 SCN5A	1.12e-03	48	125	3	C0007193
Disease	Schizophrenia	PLSCR4 NUMBL NTRK2 TSNARE1 PDLIM5 CSF2RB SBNO1 GLO1 NCAN GNAS MDGA1	1.36e-03	883	125	11	C0036341
Disease	Alzheimer's disease (biomarker_via_orthology)	NTRK2 GSR HSF1	1.93e-03	58	125	3	DOID:10652 (biomarker_via_orthology)
Disease	alpha-L-iduronidase measurement	SLC26A1 NKX1-1	2.32e-03	17	125	2	EFO_0020139
Disease	cutaneous melanoma, hair color	RREB1 ATP10A HERC2	2.34e-03	62	125	3	EFO_0000389, EFO_0003924
Disease	progression free survival, ovarian carcinoma	NTRK2 NBAS	2.61e-03	18	125	2	EFO_0001075, EFO_0004920
Disease	Congenital Myasthenic Syndromes, Presynaptic	CHRND VAMP1	2.90e-03	19	125	2	C0751884
Disease	Manic Disorder	NTRK2 SSBP2 NCAN	3.44e-03	71	125	3	C0024713
Disease	brain infarction, neuritic plaque measurement, Lewy body dementia, cerebral amyloid angiopathy, neurofibrillary tangles measurement	ATP10A SLC29A4	3.89e-03	22	125	2	EFO_0004277, EFO_0006790, EFO_0006792, EFO_0006797, EFO_0006798

Protein segments in the cluster

Peptide	Gene	Start	Entry
VSMENGLGPAPGSPE	ZNF385A	141	Q96PM9
ETSPTMGPPDASAGF	GNAS	516	P84996
MSRPAEDGPSPGALV	CHRND	361	Q07001
TPSHGPDGAVPTMAD	SLC4A3	456	P48751
AHPSPATPSGDPSME	C6orf136	131	Q5SQH8
HGGSIDSGPMPPESV	ADAM19	686	Q9H013
DSGPMPPESVGPVVA	ADAM19	691	Q9H013
GGMPSTPHESQIPGA	GSR	201	P00390
GAESGPTVDMPVPSS	GUSBP11	71	Q6P575
DPFPMVTQPEGSDGS	ADGRA1	476	Q86SQ6
GPADQMTDTPAVPST	ALMS1	1081	Q8TCU4
SEFPMGIDPTETGPL	CAMSAP1	656	Q5T5Y3
EGLSAPAPMSSAPGE	ATP10A	1386	O60312
VPEMEPPGAGDSDSI	NUMBL	346	Q9Y6R0
PMEEATTGPPAAGVS	RBSN	636	Q9H1K0
SMGGPDSPDSVDPVE	RAD21	271	O60216
SSMNSAGVSGSPEPP	ARHGEF17	316	Q96PE2
SGPGMSTPPFSSEED	DZIP1L	606	Q8IYY4
MASFPGAPVPDLSVE	MDGA1	416	Q8NFP4
TPEGSASPSMAGHEP	MUC16	2961	Q8WXI7
SPMTAAETSQEGPAP	FAM156A	16	Q8NDB6
DDPEGPVMPGSHSVE	NCBP1	296	Q09161
GSLPGTSVPPSMDAG	CSRNP1	476	Q96S65
VVSPDLGDMSPEGPQ	HERC2	2361	O95714
FASMPLPGSGETPTV	HMG20A	296	Q9NP66
VAGAPGTVMPPTTGD	HMCN2	21	Q8NDA2
GPPAQASPSSTMLGE	JADE2	111	Q9NQC1
LAPASPMASPGGSID	HSF1	271	Q00613
MSGVVPTAPEQPAGE	PLSCR4	1	Q9NRQ2
MGDPGSEIIESVPPA	KIAA1586	1	Q9HCI6
MAEPQPPSGGLTDEA	GLO1	1	Q04760
PDVGSSDPLSMVGPS	FGF21	186	Q9NSA1
SDPLSMVGPSQGRSP	FGF21	191	Q9NSA1
GTDNTSSLGPPSMPV	F8	916	P00451
GVPMAGDSSPSATPA	LRRC46	241	Q96FV0
MESGRGSSTPPGPIA	FGD3	1	Q5JSP0
MPESLDSPTSGRPGV	PDLIM5	326	Q96HC4
VGPGEVTPGDSRMPA	PSMB11	281	A5LHX3
MAAPESGPALSPGTA	NBAS	1	A2RRP1
MDPVPGTDSAPLAGL	MVB12A	1	Q96EY5
SPGSEQTPFMTAPEG	MACF1	3331	Q9UPN3
KEEPVTPTSGGGPMS	RABGAP1L	466	Q5R372
TPTSGGGPMSPQDDE	RABGAP1L	471	Q5R372
AEVEAVAPGTPTMGA	SBF1	1811	O95248
VPSSQPSVVGAGEPM	PRPF19	146	Q9UMS4
PGEMLPSLPVGSDSE	RBBP8NL	381	Q8NC74
GPVLISTADFEGPMP	BOD1L1	2181	Q8NFC6
STADFEGPMPSAPPE	BOD1L1	2186	Q8NFC6
AEMPAVETVPSPFVG	FHIP1A	816	Q05DH4
SPVAIPMSSGDTEDP	CSF2RB	691	P32927
PMEPDPTLSLSGGSA	IGSF23	141	A1L1A6
VDFGPGPGISAMEAS	KLHL11	46	Q9NVR0
GPTVVPGSATPMETG	KDM1A	86	O60341
PGSATPMETGIAETP	KDM1A	91	O60341
RPEATPSMASLGPEG	CABIN1	2001	Q9Y6J0
MGTRGPSAPVDTTPA	DCDC2C	1	A8MYV0
GPGIDVPAPDMSTGE	GLUD1	216	P00367
SGESPSEPMPTGRVV	DIS3L	321	Q8TF46
PIVISDGGIPPMSST	CDH11	571	P55287
MSVPGPSSPDGALTR	BLOC1S6	1	Q9UL45
VGGPSPASMAPTEAP	TMEM259	601	Q4ZIN3
MHPEPSEPATGGAAE	DNAAF1	1	Q8NEP3
GSAPEAAGGKPITMT	KANSL3	666	Q9P2N6
GSSMPDEFPTDIPGT	EIF2S3B	106	Q2VIR3
MEAPQGSEATLPGPA	DOK7	456	Q18PE1
MPGGDTTPEEAAAPS	DNAJC9-AS1	1	A6NH13
PTGGPTLSMSTENPE	COL15A1	381	P39059
SMPGEVEASGVAPGE	COL15A1	421	P39059
MDAPSPTGSESPFQG	RPRD2	326	Q5VT52
IDGGDAGLATPMPTP	SBNO1	26	A3KN83
DMGDTTPAEPPTPEG	RYR1	4456	P21817
EEIMSGGGSRNPTPP	EIF4G3	156	O43432
ATSAPRGTPTEPMTG	PKD1L1	1001	Q8TDX9
APAMVSVGESPGPFV	NYNRIN	231	Q9P2P1
SVPEGPFPGQMVDVS	PCDHB3	726	Q9Y5E6
PMSLGPVGSAGPVET	PARP10	376	Q53GL7
LSMVGPGSGAETPPS	NYAP1	126	Q6ZVC0
GPLSPGPFSSSMEEG	SZT2	1361	Q5T011
SGSLPPAAEASEAMP	SPHKAP	586	Q2M3C7
GTPIMPSPADSTNSG	SSBP2	251	P81877
MSAPAQPPAEGTEGT	VAMP1	1	P23763
VLPPEDMSQSGPSGS	RRP1B	491	Q14684
MSQGPPTGESSEPEA	SMG5	1	Q9UPR3
EMSQPTPSPAPAAGG	TAB1	371	Q15750
MSASGPEAPGDIPAL	NKX1-1	1	Q15270
AMPSGLSPGALDSDP	PLEKHG4	136	Q58EX7
GTSMEGSRPAAPAEP	HID1	596	Q8IV36
PTGQGGEAMPTTPES	NCAN	686	O14594
EVASGEEPALPGTPM	NCAN	986	O14594
TTPSEEPGGPQMLTS	SCN5A	631	Q14524
MSAPSTLPPGGEEGL	SSTR4	1	P31391
AVTTEEPTPMGRGPV	SH3TC1	6	Q8TE82
ASPGSPSVRSMSGPE	SRCAP	2786	Q6ZRS2
ESQMTPSHGGSPVGP	BRPF1	916	P55201
VPTDGSGPSMHPSEL	CIR1	156	Q86X95
SITGYPDPPGTMEEE	CLEC17A	6	Q6ZS10
PSSSEGGPDAVIIGM	NTRK2	491	Q16620
MAEAEGVPTTPGPAS	RETREG3	1	Q86VR2
PVGPRAAMSASSEGP	INPP5J	61	Q15735
MGTGPPAFTEVDNPA	TMTC4	291	Q5T4D3
MGDPGSEIIESVPPA	ZNF451	1	Q9Y4E5
SGPIPDMLATAEPSS	ZNF414	6	Q96IQ9
TPPGMTTSVFPVAGA	ZNF324	101	O75467
TGELVGPFVSAMPTP	ZBED2	31	Q9BTP6
VQPDTSLTPPSMGGA	ZC3H6	536	P61129
PGVAPEGSRMPEPTS	TSNARE1	81	Q96NA8
EGSRMPEPTSSPTIG	TSNARE1	86	Q96NA8
APPPTMAEEEEGTTG	ZFHX2	1141	Q9C0A1
PSAGRAPISNPGMSE	RPA2	176	P15927
SAPPGPEMNRSAEVG	SEC16A	131	O15027
ETPQAPMSGVGPVSG	PSPC1	486	Q8WXF1
SGILESPMAPAPAAT	RREB1	986	Q92766
GSSVAGDIPTGFMPP	SLC26A1	316	Q9H2B4
GGAPSPGPADTVEMV	STOML1	256	Q9UBI4
SSMGGQEEPPPAEVT	ARHGAP28	91	Q9P2N2
AGAPMREPGSPAESE	SPPL2B	561	Q8TCT7
MAEGEDVPPLPTSSG	TBC1D23	1	Q9NUY8
DTPGPETNSMEAAPG	MTHFSD	281	Q2M296
ETNSMEAAPGSPPGE	MTHFSD	286	Q2M296
ETMNTSPGTPAPAAE	TNFRSF10C	166	O14798
SPGTPAPAAEETMNT	TNFRSF10C	171	O14798
APAAEETMNTSPGTP	TNFRSF10C	176	O14798
ETMNTSPGTPAPAAE	TNFRSF10C	181	O14798
SPGTPAPAAEETMTT	TNFRSF10C	186	O14798
APAAEETMTTSPGTP	TNFRSF10C	191	O14798
ETMTTSPGTPAPAAE	TNFRSF10C	196	O14798
SPGTPAPAAEETMTT	TNFRSF10C	201	O14798
APAAEETMTTSPGTP	TNFRSF10C	206	O14798
ETMTTSPGTPAPAAE	TNFRSF10C	211	O14798
SPGTPAPAAEETMIT	TNFRSF10C	216	O14798
APAAEETMITSPGTP	TNFRSF10C	221	O14798
QGEVMGTPSSPRGPE	VWCE	361	Q96DN2
EPSAGAPPTMSSGTA	RAET1G	206	Q6H3X3
PMTGNPAEEGDVPRS	PPP1R3F	386	Q6ZSY5
SSGIDQSPGMSPVPL	TACC2	191	O95359
SFSSPGMQVSEPGDP	ARHGAP31	1126	Q2M1Z3
PDSVLNMFPGTEEGP	USB1	46	Q9BQ65
SMVVSDVVPGGPAEG	TJP3	36	O95049
EPSVAGTPDPGVVMS	SLC29A4	11	Q7RTT9
TAPAAPTMASPRGSG	PLEKHG2	36	Q9H7P9
MAERPGPPGGAVSAT	TMEM42	1	Q69YG0
GPVSMAAPTAITEAG	WNK1	1816	Q9H4A3
GEAGESSAEPPPSDM	WNK2	1731	Q9Y3S1
SSAEPPPSDMGTVGG	WNK2	1736	Q9Y3S1
VGLAPFPDTMADISP	XKR5	586	Q6UX68
PTPSPGSMVQDEVSG	VSIG2	186	Q96IQ7
SVASAMELPGPPATS	SON	376	P18583
EVVGTAPGPVFMDPE	THSD8	76	A0A1W2PP97
FGEEIPMDGEPPASS	WDR81	1046	Q562E7
TGGGMDAPQASPISP	TRERF1	41	Q96PN7
LGPPDTGMGDPASSD	TRERF1	426	Q96PN7
PGLSEGPEPSISVMV	MZB1	116	Q8WU39