Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZBTB5 ZNF808 ZNF723 THRB RREB1 ZNF681 ZNF563	2.20e-03	1412	27	7	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZBTB5 ZNF808 ZNF723 THRB RREB1 ZNF681 ZNF563	2.65e-03	1459	27	7	GO:0000977
HumanPheno	Seborrheic dermatitis	C5 RREB1 JMJD1C	2.38e-05	28	11	3	HP:0001051
HumanPheno	Hyperthyroidism	THRB RREB1 JMJD1C	5.59e-05	37	11	3	HP:0000836
HumanPheno	Abnormality of the tonsils	C3 RREB1 JMJD1C	6.07e-05	38	11	3	HP:0100765
HumanPheno	Multiple suture craniosynostosis	RREB1 JMJD1C	2.77e-04	12	11	2	HP:0011324
HumanPheno	Tricuspid atresia	RREB1 JMJD1C	2.77e-04	12	11	2	HP:0011662
MousePheno	distended cecum	SLC9A3 SLC5A1	3.43e-05	8	16	2	MP:0009480
Domain	-	C3 C5	1.03e-05	4	25	2	1.20.91.20
Domain	Anaphylatoxn_comp_syst_dom	C3 C5	1.72e-05	5	25	2	IPR001840
Domain	Anaphylatoxin_comp_syst	C3 C5	1.72e-05	5	25	2	IPR018081
Domain	ANATO	C3 C5	3.60e-05	7	25	2	SM00104
Domain	ANAPHYLATOXIN_2	C3 C5	3.60e-05	7	25	2	PS01178
Domain	ANAPHYLATOXIN_1	C3 C5	3.60e-05	7	25	2	PS01177
Domain	ANATO	C3 C5	3.60e-05	7	25	2	PF01821
Domain	Anaphylatoxin/fibulin	C3 C5	3.60e-05	7	25	2	IPR000020
Domain	A2M_N_2	C3 C5	4.79e-05	8	25	2	SM01359
Domain	-	C3 C5	4.79e-05	8	25	2	2.60.40.690
Domain	A2M_recep	C3 C5	4.79e-05	8	25	2	SM01361
Domain	A2M	C3 C5	4.79e-05	8	25	2	SM01360
Domain	A2M_N	C3 C5	7.69e-05	10	25	2	PF01835
Domain	A2M_N_2	C3 C5	7.69e-05	10	25	2	PF07703
Domain	A2M_recep	C3 C5	7.69e-05	10	25	2	PF07677
Domain	A2M_comp	C3 C5	7.69e-05	10	25	2	PF07678
Domain	A2M	C3 C5	7.69e-05	10	25	2	PF00207
Domain	A2M_N	C3 C5	7.69e-05	10	25	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C3 C5	7.69e-05	10	25	2	IPR009048
Domain	A2M_N_2	C3 C5	7.69e-05	10	25	2	IPR011625
Domain	A2M_comp	C3 C5	7.69e-05	10	25	2	IPR011626
Domain	ALPHA_2_MACROGLOBULIN	C3 C5	7.69e-05	10	25	2	PS00477
Domain	Macroglobln_a2	C3 C5	7.69e-05	10	25	2	IPR001599
Domain	-	C3 C5	1.13e-04	12	25	2	1.50.10.20
Domain	-	ZBTB5 ZNF808 RREB1 ZNF781 ZNF681 ZNF563	2.21e-04	679	25	6	3.30.160.60
Domain	C345C	C3 C5	2.31e-04	17	25	2	SM00643
Domain	zf-C2H2	ZBTB5 ZNF808 RREB1 ZNF781 ZNF681 ZNF563	2.47e-04	693	25	6	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZBTB5 ZNF808 RREB1 ZNF781 ZNF681 ZNF563	2.49e-04	694	25	6	IPR013087
Domain	Terpenoid_cyclase/PrenylTrfase	C3 C5	2.60e-04	18	25	2	IPR008930
Domain	NTR	C3 C5	2.90e-04	19	25	2	PF01759
Domain	Netrin_module_non-TIMP	C3 C5	2.90e-04	19	25	2	IPR018933
Domain	Netrin_domain	C3 C5	4.28e-04	23	25	2	IPR001134
Domain	NTR	C3 C5	4.28e-04	23	25	2	PS50189
Domain	ZINC_FINGER_C2H2_2	ZBTB5 ZNF808 RREB1 ZNF781 ZNF681 ZNF563	4.50e-04	775	25	6	PS50157
Domain	ZINC_FINGER_C2H2_1	ZBTB5 ZNF808 RREB1 ZNF781 ZNF681 ZNF563	4.57e-04	777	25	6	PS00028
Domain	Znf_C2H2-like	ZBTB5 ZNF808 RREB1 ZNF781 ZNF681 ZNF563	5.19e-04	796	25	6	IPR015880
Domain	TIMP-like_OB-fold	C3 C5	5.48e-04	26	25	2	IPR008993
Domain	Znf_C2H2	ZBTB5 ZNF808 RREB1 ZNF781 ZNF681 ZNF563	5.51e-04	805	25	6	IPR007087
Domain	ZnF_C2H2	ZBTB5 ZNF808 RREB1 ZNF781 ZNF681 ZNF563	5.62e-04	808	25	6	SM00355
Domain	zf-C2H2_6	ZNF808 RREB1 ZNF681	8.23e-03	314	25	3	PF13912
Domain	KRAB	ZNF808 ZNF681 ZNF563	1.18e-02	358	25	3	PS50805
Domain	KRAB	ZNF808 ZNF681 ZNF563	1.18e-02	358	25	3	PF01352
Domain	KRAB	ZNF808 ZNF681 ZNF563	1.27e-02	369	25	3	SM00349
Domain	KRAB	ZNF808 ZNF681 ZNF563	1.28e-02	370	25	3	IPR001909
Domain	Thioredoxin-like_fold	SELENOP NHLRC2	1.34e-02	132	25	2	IPR012336
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C3 C5	3.60e-05	7	19	2	MM14685
Pathway	BIOCARTA_ALTERNATIVE_PATHWAY	C3 C5	4.80e-05	8	19	2	MM1582
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C3 C5	4.80e-05	8	19	2	M27031
Pathway	BIOCARTA_ALTERNATIVE_PATHWAY	C3 C5	6.16e-05	9	19	2	M22072
Pathway	WP_ACQUIRED_PARTIAL_LIPODYSTROPHY_BARRAQUERSIMONS_SYNDROME	C3 C5	7.70e-05	10	19	2	M42576
Pathway	BIOCARTA_LECTIN_PATHWAY	C3 C5	9.40e-05	11	19	2	MM1430
Pathway	BIOCARTA_CLASSIC_PATHWAY	C3 C5	1.13e-04	12	19	2	MM1368
Pathway	WP_COMPLEMENTMEDIATED_INFLAMMATION_OF_PULMONARY_ALVEOLUS_IN_COVID19_HYPOTHETICAL_PATHWAY	C3 C5	1.13e-04	12	19	2	M48316
Pathway	BIOCARTA_LECTIN_PATHWAY	C3 C5	1.33e-04	13	19	2	M4732
Pathway	BIOCARTA_CLASSIC_PATHWAY	C3 C5	1.79e-04	15	19	2	M7146
Pathway	BIOCARTA_LAIR_PATHWAY	C3 C5	2.31e-04	17	19	2	M3952
Pathway	WP_CELLS_AND_MOLECULES_INVOLVED_IN_LOCAL_ACUTE_INFLAMMATORY_RESPONSE	C3 C5	2.31e-04	17	19	2	M39733
Pathway	BIOCARTA_COMP_PATHWAY	C3 C5	2.31e-04	17	19	2	MM1369
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	C3 C5	2.31e-04	17	19	2	MM15944
Pathway	BIOCARTA_COMP_PATHWAY	C3 C5	3.22e-04	20	19	2	M917
Pathway	WP_COMPLEMENT_ACTIVATION	C3 C5	3.91e-04	22	19	2	M39502
Pathway	WP_PROXIMAL_TUBULE_TRANSPORT	SLC9A3 SLC5A1	2.63e-03	57	19	2	M39812
Pathway	KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	C3 C5	3.83e-03	69	19	2	M16894
Pathway	REACTOME_COMPLEMENT_CASCADE	C3 C5	5.62e-03	84	19	2	MM14653
Pathway	WP_ALLOGRAFT_REJECTION	C3 C5	6.29e-03	89	19	2	M39398
Pathway	WP_COMPLEMENT_SYSTEM	C3 C5	7.28e-03	96	19	2	M39581
Pubmed	Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular injury in deoxycorticosterone acetate-salt mice.	C3 C5	6.25e-07	2	28	2	25573852
Pubmed	Alterations in plasma complement levels after human ischemic stroke.	C3 C5	6.25e-07	2	28	2	16823297
Pubmed	Genetic variants of C5 and polymorphisms of C3 in Chinese patients with paroxysmal nocturnal hemoglobinuria.	C3 C5	6.25e-07	2	28	2	27307199
Pubmed	C1q is elevated during chronic Staphylococcus epidermidis central nervous system catheter infection.	C3 C5	6.25e-07	2	28	2	38881889
Pubmed	Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice.	C3 C5	6.25e-07	2	28	2	30714990
Pubmed	The proinflammatory mediators C3a and C5a are essential for liver regeneration.	C3 C5	6.25e-07	2	28	2	12975457
Pubmed	The role of the complement anaphylatoxins in the recruitment of eosinophils.	C3 C5	6.25e-07	2	28	2	18039528
Pubmed	Complement factor C5 but not C3 contributes significantly to hydrosalpinx development in mice infected with Chlamydia muridarum.	C3 C5	6.25e-07	2	28	2	24842924
Pubmed	Complement anaphylatoxins C3a and C5a: Emerging roles in cancer progression and treatment.	C3 C5	6.25e-07	2	28	2	29155219
Pubmed	Human skin mast cells express complement factors C3 and C5.	C3 C5	6.25e-07	2	28	2	23833239
Pubmed	C3a and C5a are chemotactic factors for human mesenchymal stem cells, which cause prolonged ERK1/2 phosphorylation.	C3 C5	6.25e-07	2	28	2	19265162
Pubmed	Complement C3 variant and the risk of age-related macular degeneration.	C3 C5	6.25e-07	2	28	2	17634448
Pubmed	Copy number variations and gene polymorphisms of complement components in ocular Behcet's disease and Vogt-Koyanagi-Harada syndrome.	C3 C5	6.25e-07	2	28	2	26269006
Pubmed	Acute lung injury induced by lipopolysaccharide is independent of complement activation.	C3 C5	6.25e-07	2	28	2	18490769
Pubmed	Targeting complement component 5a promotes vascular integrity and limits airway remodeling.	C3 C5	6.25e-07	2	28	2	23530212
Pubmed	Plasma levels of complement activation fragments C3b and sC5b-9 significantly increased in patients with thrombotic microangiopathy after allogeneic stem cell transplantation.	C3 C5	6.25e-07	2	28	2	28801815
Pubmed	Expression and characterization of the C345C/NTR domains of complement components C3 and C5.	C3 C5	6.25e-07	2	28	2	14662858
Pubmed	C3a and C5a promote renal ischemia-reperfusion injury.	C3 C5	6.25e-07	2	28	2	22797180
Pubmed	Complement effectors, C5a and C3a, in cystic fibrosis lung fluid correlate with disease severity.	C3 C5	6.25e-07	2	28	2	28278205
Pubmed	Intravascular clearance of disseminating Cryptococcus neoformans in the brain can be improved by enhancing neutrophil recruitment in mice.	C3 C5	6.25e-07	2	28	2	27109176
Pubmed	Generation of C5a in the absence of C3: a new complement activation pathway.	C3 C5	6.25e-07	2	28	2	16715088
Pubmed	Functions of the complement components C3 and C5 during sepsis.	C3 C5	6.25e-07	2	28	2	18587006
Pubmed	Novel evidence that crosstalk between the complement, coagulation and fibrinolysis proteolytic cascades is involved in mobilization of hematopoietic stem/progenitor cells (HSPCs).	C3 C5	6.25e-07	2	28	2	24667943
Pubmed	Complement decay-accelerating factor inhibits inflammation-induced myopia development.	C3 C5	6.25e-07	2	28	2	38795684
Pubmed	Complement C3 and C5 deficiency affects fracture healing.	C3 C5	6.25e-07	2	28	2	24260573
Pubmed	Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis.	C3 C5	1.87e-06	3	28	2	20625009
Pubmed	Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice.	C3 C5	1.87e-06	3	28	2	17383432
Pubmed	Complement system is activated in stenotic aortic valves.	C3 C5	1.87e-06	3	28	2	17498719
Pubmed	Complement serves as a switch between CD4+ T cell-independent and -dependent RBC antibody responses.	C3 C5	1.87e-06	3	28	2	30429364
Pubmed	Complement component C3 mediates inflammatory injury following focal cerebral ischemia.	C3 C5	1.87e-06	3	28	2	16778128
Pubmed	Intestinal function of gene-targeted mice lacking serum- and glucocorticoid-inducible kinase 1.	SLC9A3 SLC5A1	1.87e-06	3	28	2	16410368
Pubmed	Chromosomal locations and gonadal dependence of genes that mediate resistance to ectromelia (mousepox) virus-induced mortality.	C3 C5	1.87e-06	3	28	2	2002550
Pubmed	Alterations in gene expression of complement components in chronic rhinosinusitis.	C3 C5	1.87e-06	3	28	2	20109314
Pubmed	Long-term sublingual immunotherapy for Japanese cedar pollinosis and the levels of IL-17A and complement components 3a and 5a.	C3 C5	1.87e-06	3	28	2	25934649
Pubmed	Antigen-presenting cell-derived complement modulates graft-versus-host disease.	C3 C5	1.87e-06	3	28	2	22585573
Pubmed	Complement Component 3 Negatively Regulates Antibody Response by Modulation of Red Blood Cell Antigen.	C3 C5	1.87e-06	3	28	2	29942300
Pubmed	Carboxypeptidase B2 and N play different roles in regulation of activated complements C3a and C5a in mice.	C3 C5	1.87e-06	3	28	2	29383821
Pubmed	Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection.	SLC9A3 SLC5A1	1.87e-06	3	28	2	37350393
Pubmed	Transcriptional regulation of NHE3 and SGLT1 by the circadian clock protein Per1 in proximal tubule cells.	SLC9A3 SLC5A1	1.87e-06	3	28	2	26377793
Pubmed	The anti-inflammatory effect of combined complement and CD14 inhibition is preserved during escalating bacterial load.	C3 C5	1.87e-06	3	28	2	25907631
Pubmed	Aspergillus fumigatus conidial metalloprotease Mep1p cleaves host complement proteins.	C3 C5	1.87e-06	3	28	2	30139746
Pubmed	C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation.	C3 C5	1.87e-06	3	28	2	26831747
Pubmed	Expression of complement C3, C5, C3aR and C5aR1 genes in resting and activated CD4+ T cells.	C3 C5	1.87e-06	3	28	2	30612786
Pubmed	Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder.	C3 C5	1.87e-06	3	28	2	34543680
Pubmed	Complement C5 but not C3 is expendable for tissue factor activation by cofactor-independent antiphospholipid antibodies.	C3 C5	1.87e-06	3	28	2	29716893
Pubmed	Combined inhibition of complement and CD14 efficiently attenuated the inflammatory response induced by Staphylococcus aureus in a human whole blood model.	C3 C5	1.87e-06	3	28	2	24516199
Pubmed	Complement-dependent acute-phase expression of C-reactive protein and serum amyloid P-component.	C3 C5	1.87e-06	3	28	2	10878380
Pubmed	Carboxypeptidase B2 deficiency reveals opposite effects of complement C3a and C5a in a murine polymicrobial sepsis model.	C3 C5	1.87e-06	3	28	2	25851247
Pubmed	Expression of the complement system's activation factors in plasma of patients with early/late-onset severe pre-eclampsia.	C3 C5	1.87e-06	3	28	2	27461873
Pubmed	Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice.	C3 C5	1.87e-06	3	28	2	16547268
Pubmed	Early complementopathy after multiple injuries in humans.	C3 C5	3.75e-06	4	28	2	22258234
Pubmed	The development of atypical hemolytic uremic syndrome depends on complement C5.	C3 C5	3.75e-06	4	28	2	21148255
Pubmed	Intracellular complement (complosome) is expressed in hematopoietic stem/progenitor cells (HSPCs) and regulates cell trafficking, metabolism and proliferation in an intracrine Nlrp3 inflammasome-dependent manner.	C3 C5	3.75e-06	4	28	2	37055506
Pubmed	Impaired mast cell-dependent natural immunity in complement C3-deficient mice.	C3 C5	3.75e-06	4	28	2	9367154
Pubmed	Expressions of C5a and its receptor CD88 after spinal cord injury in C3-deficient mice.	C3 C5	3.75e-06	4	28	2	23033813
Pubmed	Molecular cloning and characterization of the human anaphylatoxin C3a receptor.	C3 C5	3.75e-06	4	28	2	8702752
Pubmed	C3a, C5a renal expression and their receptors are correlated to severity of IgA nephropathy.	C3 C5	3.75e-06	4	28	2	24327134
Pubmed	Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N.	C3 C5	3.75e-06	4	28	2	11939578
Pubmed	Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis.	C3 C5	3.75e-06	4	28	2	31076642
Pubmed	Complement activation by recombinant HIV-1 glycoprotein gp120.	C3 C5	3.75e-06	4	28	2	7911492
Pubmed	Complement C3b interactions studied with surface plasmon resonance technique.	C3 C5	3.75e-06	4	28	2	11367533
Pubmed	Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment.	C3 C5	3.75e-06	4	28	2	29362231
Pubmed	Complement factors in newly diagnosed Nigerian schizoprenic patients and those on antipsychotic therapy.	C3 C5	3.75e-06	4	28	2	23235303
Pubmed	A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci.	C3 C5	3.75e-06	4	28	2	23189195
Pubmed	Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma.	C3 C5	3.75e-06	4	28	2	15278436
Pubmed	C5 inhibition prevents renal failure in a mouse model of lethal C3 glomerulopathy.	C3 C5	3.75e-06	4	28	2	28139294
Pubmed	Histone Modifier Genes Alter Conotruncal Heart Phenotypes in 22q11.2 Deletion Syndrome.	RREB1 JMJD1C	3.75e-06	4	28	2	26608785
Pubmed	Levels of complement components iC3b, C3c, C4, and SC5b-9 in peritoneal fluid and serum of infertile women with endometriosis.	C3 C5	3.75e-06	4	28	2	17482181
Pubmed	Phylogeny of the C3/C4/C5 complement-component gene family indicates that C5 diverged first.	C3 C5	3.75e-06	4	28	2	8015436
Pubmed	Experimentally-induced anti-myeloperoxidase vasculitis does not require properdin, MASP-2 or bone marrow-derived C5.	C3 C5	3.75e-06	4	28	2	27235854
Pubmed	Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency.	C3 C5	6.24e-06	5	28	2	25039245
Pubmed	Drusen complement components C3a and C5a promote choroidal neovascularization.	C3 C5	6.24e-06	5	28	2	16452172
Pubmed	New concepts on the therapeutic control of complement anaphylatoxin receptors.	C3 C5	6.24e-06	5	28	2	28576324
Pubmed	A novel role of complement in retinal degeneration.	C3 C5	6.24e-06	5	28	2	23074214
Pubmed	Complement activation triggers metalloproteinases release inducing cervical remodeling and preterm birth in mice.	C3 C5	6.24e-06	5	28	2	21801872
Pubmed	Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development.	C3 C5	6.24e-06	5	28	2	28223279
Pubmed	Formation of high affinity C5 convertase of the classical pathway of complement.	C3 C5	6.24e-06	5	28	2	12878586
Pubmed	Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a.	C3 C5	6.24e-06	5	28	2	18063050
Pubmed	C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a.	C3 C5	6.24e-06	5	28	2	17322907
Pubmed	Identification of complement activation sites in human immunodeficiency virus type-1 glycoprotein gp120.	C3 C5	6.24e-06	5	28	2	8630395
Pubmed	Predominant role for C5b-9 in renal ischemia/reperfusion injury.	C3 C5	6.24e-06	5	28	2	10811844
Pubmed	Role of complement receptors 1 and 2 (CD35 and CD21), C3, C4, and C5 in survival by mice of Staphylococcus aureus bacteremia.	C3 C5	6.24e-06	5	28	2	15192652
Pubmed	Complement is a central mediator of radiotherapy-induced tumor-specific immunity and clinical response.	C3 C5	9.36e-06	6	28	2	25888260
Pubmed	Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections.	C3 C5	9.36e-06	6	28	2	31274379
Pubmed	Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis.	C3 C5	9.36e-06	6	28	2	18567839
Pubmed	Elucidation of the early events contributing to zymosan-induced multiple organ dysfunction syndrome using MIP-1alpha, C3 knockout, and C5-deficient mice.	C3 C5	9.36e-06	6	28	2	10565608
Pubmed	Clearance of Bordetella parapertussis from the lower respiratory tract requires humoral and cellular immunity.	C3 C5	9.36e-06	6	28	2	16177324
Pubmed	The Complement System Is Critical in Maintaining Retinal Integrity during Aging.	C3 C5	9.36e-06	6	28	2	29497373
Pubmed	Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry.	C3 C5	9.36e-06	6	28	2	19136662
Pubmed	Fungal dissemination is limited by liver macrophage filtration of the blood.	C3 C5	9.36e-06	6	28	2	31594939
Pubmed	Complement activation pathways in murine immune complex-induced arthritis and in C3a and C5a generation in vitro.	C3 C5	9.36e-06	6	28	2	19843088
Pubmed	Efficient osteoclast differentiation requires local complement activation.	C3 C5	1.31e-05	7	28	2	20709903
Pubmed	Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.	C3 C5	1.31e-05	7	28	2	23263555
Pubmed	C1q governs deposition of circulating immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment.	C3 C5	1.31e-05	7	28	2	15466618
Pubmed	The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4.	C3 C5	1.31e-05	7	28	2	16301658
Pubmed	Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin.	C3 C5	1.31e-05	7	28	2	18490515
Pubmed	Characterization of the pVHL Interactome in Human Testis Using High-Throughput Library Screening.	SELENOP TTC3 FBXO34	1.63e-05	61	28	3	35205757
Pubmed	Synergy between the classical and alternative pathways of complement is essential for conferring effective protection against the pandemic influenza A(H1N1) 2009 virus infection.	C3 C5	1.74e-05	8	28	2	28301559
Pubmed	Molecular organization and function of the complement system.	C3 C5	1.74e-05	8	28	2	3052276
Pubmed	C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens.	C3 C5	1.74e-05	8	28	2	24474777
Cytoband	19p12	ZNF723 ZNF681	1.39e-03	90	28	2	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF723 ZNF681	2.53e-03	122	28	2	chr19p12
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C3 C5	4.17e-05	9	20	2	1234
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZBTB5 ZNF808 RREB1 ZNF781 ZNF681 ZNF563	9.23e-05	718	20	6	28
GeneFamily	Complement system\|Sushi domain containing	C3 C5	7.16e-04	36	20	2	492
GeneFamily	Endogenous ligands	C3 C5	2.78e-02	237	20	2	542
ToppCell	lung-Type_II_Pneumocytes\|lung / shred on tissue and cell subclass	C3 SELENOP C5	1.05e-04	147	28	3	8a3039de45b8087f8319e2e37329acf7278219b7
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A3 THRB ZNF681	1.43e-04	163	28	3	cab65dabeea58141c649e4fec5e0123beb3de1b3
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	C3 THRB SLC5A1	1.56e-04	168	28	3	b275e951ff7109e36da22fc17bd4516f9b9432c4
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	C3 THRB SLC5A1	1.56e-04	168	28	3	a0dbe2ee697e29b32aa5f8326445e067ff66c154
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	C3 THRB SLC5A1	1.56e-04	168	28	3	0757a5af953901a8faed5774ffec4755fc9c0a6e
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELENOP SLFN5 THRB	1.62e-04	170	28	3	067657ca7fcf5a0ffbd168b5c4609a30ca508f22
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELENOP SLFN5 THRB	1.82e-04	177	28	3	26bad614560609d318bfc9c235a698bca4e1c22c
ToppCell	LV\|World / Chamber and Cluster_Paper	NHLRC2 MYH7B SLC5A1	1.92e-04	180	28	3	5ac6f485a58bb29462fec02dfbe8eb70864eafe3
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D175\|Adult / Lineage, Cell type, age group and donor	C3 C5 THRB	2.18e-04	188	28	3	ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCell	renal_medulla_nuclei-Adult_normal_reference\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	THRB RREB1 JMJD1C	2.25e-04	190	28	3	f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCell	P07-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell_of_alveolus\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SELENOP NHLRC2 SLFN5	2.25e-04	190	28	3	5d25e40bc2cca314f4265e4001a546e6d99e2a79
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	C3 SLC9A3 SLC5A1	2.25e-04	190	28	3	3c337374d89e69cc0a78e65a4a7e21db7b050fcd
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	C3 SLC9A3 SLC5A1	2.25e-04	190	28	3	23f2ac4da431211084bb6ab0494c2e0b69547cb6
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SELENOP NHLRC2 SLFN5	2.28e-04	191	28	3	718330bb97fe8a1ffd0c82e9af23311a32eacfe1
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SELENOP NHLRC2 SLFN5	2.32e-04	192	28	3	2360824910cd471c8286ca369ba144d90d984602
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SELENOP NHLRC2 SLFN5	2.35e-04	193	28	3	ac1073bf4d3868841226b850b058f1e27326a14e
ToppCell	(7)_Epithelial_cells\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	C3 SELENOP MYH7B	2.39e-04	194	28	3	413e8b9f1e15be363a7f4a8f727af3eeb9e9a928
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SELENOP NHLRC2 SLFN5	2.39e-04	194	28	3	c6cee7d15af76f9a60d7f414ef0bcc1735c47b7a
ToppCell	PND14-Endothelial-Endothelial_blood-vessel\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SELENOP NHLRC2 SLFN5	2.39e-04	194	28	3	32962060d80f3edffbe9f0ecad3000c3a9817865
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Mesenchymal\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELENOP TTC3 JMJD1C	2.42e-04	195	28	3	4d63e0dca30ae57960459d2fbcba09122273e37b
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Mesenchymal-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELENOP TTC3 JMJD1C	2.42e-04	195	28	3	661af601a3561fe3aacf2444ad7b8927fa88b48a
ToppCell	(7)_Epithelial-B_(AT2)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	C3 SELENOP C5	2.46e-04	196	28	3	345d4cc062b43bca9d506fbf23363469a9ba496f
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	C3 THRB SLC5A1	2.46e-04	196	28	3	020110cd79453df9546fb20802fe38ecadd9fe74
ToppCell	AT2_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	C3 C5 SLFN5	2.50e-04	197	28	3	5e0d222872a25bb9e9069d3dffda2844bb69874a
ToppCell	PSB-critical-LOC-Epithelial-Secretory\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	C3 THRB SLC5A1	2.54e-04	198	28	3	e4cbe4032dba0da3fd46817ea9ad86ba9217f747
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	C3 SELENOP JMJD1C	2.54e-04	198	28	3	62cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-mature_enterocytic\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELENOP SLC9A3 SLC5A1	2.54e-04	198	28	3	8fac96132663f54566136ef54b53684d31dfde32
ToppCell	TCGA-Skin-Metastatic-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	C3 SELENOP JMJD1C	2.54e-04	198	28	3	af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-mature_enterocytic\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELENOP SLC9A3 SLC5A1	2.54e-04	198	28	3	222a060c2c63d30da34e4b71c37aa27a048d7d09
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELENOP SLC9A3 SLC5A1	2.54e-04	198	28	3	c48b3f026b16d48b8eca9f74dc1e3f3f39a89322
ToppCell	TCGA-Skin-Metastatic\|TCGA-Skin / Sample_Type by Project: Shred V9	C3 SELENOP JMJD1C	2.54e-04	198	28	3	ad39cce004867f083f8da1954e0cf5a263815184
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELENOP SLC9A3 SLC5A1	2.54e-04	198	28	3	2967fb2d94662997bfe932ac299c80d6f182fb48
ToppCell	Epithelial_cells\|World / lung cells shred on cell class, cell subclass, sample id	C3 SELENOP MYH7B	2.57e-04	199	28	3	bbe69e44b7970f57628365ae771790f2b13d0cae
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	C3 C5 FBXO34	2.57e-04	199	28	3	121de4e02585de3a3010398387c523bacf8ce546
ToppCell	(04)_Interm._basal>secr.\|World / shred by cell type by condition	C3 SELENOP FBXO34	2.57e-04	199	28	3	ed399244433f781fc291a9bff16825b8a3ca294f
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	C3 SELENOP C5	2.57e-04	199	28	3	2dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELENOP SLC9A3 SLC5A1	2.61e-04	200	28	3	3e13c9a4ba99a7dfbf738b0fb63fb54b4dee5897
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELENOP SLC9A3 SLC5A1	2.61e-04	200	28	3	73bfdf068a8ecbefc1e6afe9686df73658ee042f
ToppCell	ileum-Absorptive_Enterocytes\|ileum / shred on tissue and cell subclass	SELENOP SLC5A1	3.02e-04	41	28	2	650cec538c6acd92f45d804b3c94248c6231aa21
Computational	Genes in the cancer module 112.	SELENOP C5 THRB RREB1	3.70e-04	260	15	4	MODULE_112
Computational	Genes in the cancer module 58.	C3 C5	3.76e-04	21	15	2	MODULE_58
Computational	Complement.	C3 C5	4.52e-04	23	15	2	MODULE_130
Drug	rEV576 protein, tick	C3 C5	4.06e-06	3	27	2	ctd:C539676
Drug	1,2,3,6,7,8-hexachlorodibenzo-p-dioxin	C3 C5	2.03e-05	6	27	2	CID000042540
Drug	Staphylococcal Protein A	C3 C5	2.83e-05	7	27	2	ctd:D013205
Drug	Intravenous Immunoglobulin	C3 C5	3.78e-05	8	27	2	DB00028
Drug	2,3,5-trichlorophenol	C3 C5	4.85e-05	9	27	2	CID000013619
Drug	3,5-dichlorophenol	C3 C5	4.85e-05	9	27	2	CID000011571
Drug	cyanoacetylene	C3 C5	6.06e-05	10	27	2	CID000014055
Drug	styrofoam	C3 C5	6.06e-05	10	27	2	ctd:C024075
Drug	cobra venom factor	C3 C5	8.87e-05	12	27	2	ctd:C016310
Drug	tetrachlorophenol	C3 C5	1.22e-04	14	27	2	CID000021013
Drug	2,2',4,4'-tetrahydroxybenzophenone	C3 THRB	1.22e-04	14	27	2	ctd:C035476
Disease	factor VIII deficiency (is_marker_for)	C3 C5	5.20e-06	4	28	2	DOID:12134 (is_marker_for)
Disease	paroxysmal nocturnal hemoglobinuria (is_implicated_in)	C3 C5	1.30e-05	6	28	2	DOID:0060284 (is_implicated_in)
Disease	myeloid white cell count	GLMN C3 SELENOP NHLRC2 RREB1 JMJD1C FBXO34	2.10e-05	937	28	7	EFO_0007988
Disease	22q11 partial monosomy syndrome	RREB1 JMJD1C	3.11e-05	9	28	2	C3266101
Disease	Asymmetric crying face association	RREB1 JMJD1C	3.89e-05	10	28	2	C0431406
Disease	22q11 Deletion Syndrome	RREB1 JMJD1C	3.89e-05	10	28	2	C2936346
Disease	DiGeorge Syndrome	RREB1 JMJD1C	1.03e-04	16	28	2	C0012236
Disease	CONOTRUNCAL ANOMALY FACE SYNDROME	RREB1 JMJD1C	1.03e-04	16	28	2	C0795907
Disease	Shprintzen syndrome	RREB1 JMJD1C	1.03e-04	16	28	2	C0220704
Disease	Antibody Deficiency Syndrome	C3 C5	1.17e-04	17	28	2	C0003257
Disease	Immunologic Deficiency Syndromes	C3 C5	2.17e-04	23	28	2	C0021051
Disease	adult respiratory distress syndrome (is_marker_for)	C3 C5	2.78e-04	26	28	2	DOID:11394 (is_marker_for)
Disease	Complement deficiency disease	C3 C5	4.50e-04	33	28	2	C0272242
Disease	Insulin Sensitivity	C3 SELENOP	1.49e-03	60	28	2	C0920563
Disease	Insulin Resistance	C3 SELENOP	1.49e-03	60	28	2	C0021655
Disease	response to opioid	SELENOP NHLRC2	1.53e-03	61	28	2	EFO_0008541
Disease	lymphocyte count	GLMN C3 NHLRC2 THRB RREB1 JMJD1C	2.17e-03	1464	28	6	EFO_0004587

Protein segments in the cluster

Peptide	Gene	Start	Entry
VALKCTCCYFKFIIE	FBXO34	596	Q9NWN3
LGEACKKVFLDCCNY	C3	716	P01024
DYKNFVCCAVCNKII	C6orf163	6	Q5TEZ5
ILFCALAVCKKIAYC	MAEL	291	Q96JY0
QKCGFVVCLDCYKAK	JMJD1C	1861	Q15652
FSVDEKCACYKIVGA	MYH7B	386	A7E2Y1
LCGKIVVLDFFTYCC	NHLRC2	76	Q8NBF2
KHSVVKKCCYDGACV	C5	691	P01031
VENVCGCAKYECVKA	OTOG	2671	Q6ZRI0
YGLCQCCKALIEFTK	GLMN	171	Q92990
VLCAYCYEKVCKETA	MRPL32	121	Q9BYC8
AITFCGICCQKYVKA	SLC9A3	311	P48764
YEVLDCCCCVKNKTV	SMIM18	56	P0DKX4
EAIKIAYCEKKCGNC	SELENOP	161	P49908
LFVYAVRECCKCIDG	ALG8	116	Q9BVK2
KQIFCVADVCTDCKF	C15orf32	131	Q32M92
SDCGVFVLQYCKCLA	SENP5	711	Q96HI0
VVEGARKYACKICCK	ZBTB5	606	O15062
EVFHCPVCFKEFVCK	RREB1	206	Q92766
TRVNCYKCEECGKAF	ZNF723	196	P0DPD5
CQECRFKKCIYVGMA	THRB	161	P10828
FKGFIRISCCQYCKI	TTC3	671	P53804
CKVCDKAFVCRSYVA	ZNF808	681	Q8N4W9
CKVCGKAFVYPSVCQ	ZNF563	451	Q8TA94
ICTRVNFYKCEDCGK	ZNF681	191	Q96N22
EKIACVVPSECEKYC	SLC5A1	341	P13866
YECKECGKVFICCST	ZNF781	61	Q8N8C0
GYVCAIKVEKFCCAV	SLFN5	291	Q08AF3