Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inhibitory MHC class I receptor activity	LILRA1 LILRA3 LILRB1	4.70e-05	12	122	3	GO:0032396
GeneOntologyMolecularFunction	protein phosphatase 1 binding	LILRA1 LILRB1 PPP1CA PPP1CC	6.00e-05	35	122	4	GO:0008157
GeneOntologyMolecularFunction	MHC class I receptor activity	LILRA1 LILRA3 LILRB1	1.70e-04	18	122	3	GO:0032393
GeneOntologyMolecularFunction	protein kinase binding	SPDYE17 TPCN2 SPDYE10 DSCAM INSR SPDYE12 GRM5 PPP1CB PPP1CC SPDYE11 SPDYE15 SPDYE3 IRAK4 SPDYE8 SPDYE14	2.83e-04	873	122	15	GO:0019901
GeneOntologyMolecularFunction	HLA-A specific inhibitory MHC class I receptor activity	LILRA1 LILRB1	3.66e-04	5	122	2	GO:0030107
GeneOntologyMolecularFunction	cell-cell adhesion mediator activity	PRTG DSCAM NFASC PPP1CA	5.29e-04	61	122	4	GO:0098632
GeneOntologyMolecularFunction	immune receptor activity	EPOR XCR1 LILRA1 LILRA3 IL20RA LILRB1	5.33e-04	165	122	6	GO:0140375
GeneOntologyMolecularFunction	HLA-B specific inhibitory MHC class I receptor activity	LILRA1 LILRB1	5.47e-04	6	122	2	GO:0030109
GeneOntologyMolecularFunction	potassium channel activator activity	LRRC52 LRRC26	5.47e-04	6	122	2	GO:0099104
GeneOntologyMolecularFunction	MHC class Ib protein complex binding	LILRA1 LILRB1	7.62e-04	7	122	2	GO:0023025
GeneOntologyMolecularFunction	kinase binding	SPDYE17 TPCN2 SPDYE10 DSCAM INSR SPDYE12 GRM5 PPP1CB PPP1CC SPDYE11 SPDYE15 SPDYE3 IRAK4 SPDYE8 SPDYE14	8.38e-04	969	122	15	GO:0019900
GeneOntologyMolecularFunction	tRNA-specific adenosine deaminase activity	ADAD2 ADAT1	1.01e-03	8	122	2	GO:0008251
GeneOntologyMolecularFunction	cell adhesion mediator activity	PRTG DSCAM NFASC PPP1CA	1.21e-03	76	122	4	GO:0098631
GeneOntologyMolecularFunction	histone H4K16 acetyltransferase activity	JADE2 JADE1	1.30e-03	9	122	2	GO:0046972
GeneOntologyMolecularFunction	histone H3K14 acetyltransferase activity	JADE2 JADE1	1.30e-03	9	122	2	GO:0036408
GeneOntologyMolecularFunction	channel activator activity	LRRC52 LRRC26	1.61e-03	10	122	2	GO:0099103
GeneOntologyMolecularFunction	myosin phosphatase activity	PPP1CA PPP1CB PPP1CC SSH3	1.83e-03	85	122	4	GO:0017018
GeneOntologyMolecularFunction	protein phosphatase binding	LILRA1 INSR LILRB1 PPP1CA PPP1CC CDC27	1.85e-03	210	122	6	GO:0019903
GeneOntologyMolecularFunction	histone H4K8 acetyltransferase activity	JADE2 JADE1	1.96e-03	11	122	2	GO:0043996
GeneOntologyMolecularFunction	histone H4K5 acetyltransferase activity	JADE2 JADE1	1.96e-03	11	122	2	GO:0043995
GeneOntologyMolecularFunction	IgM binding	LILRA1 LILRB1	1.96e-03	11	122	2	GO:0001791
GeneOntologyMolecularFunction	transporter activator activity	LRRC52 LRRC26	2.35e-03	12	122	2	GO:0141109
GeneOntologyMolecularFunction	histone H4K12 acetyltransferase activity	JADE2 JADE1	2.35e-03	12	122	2	GO:0043997
GeneOntologyBiologicalProcess	cytokine-mediated signaling pathway	EPOR XCR1 LILRA1 LILRA3 TUT4 MUC19 IL20RA LILRB1 STAT5A STAT5B LRP8 GH1 EDAR IRAK4 USP27X	6.07e-07	577	113	15	GO:0019221
GeneOntologyBiologicalProcess	interleukin-10-mediated signaling pathway	LILRA1 LILRA3 LILRB1	2.56e-05	11	113	3	GO:0140105
GeneOntologyBiologicalProcess	natural killer cell differentiation	PGLYRP2 STAT5A STAT5B HECTD1	5.46e-05	38	113	4	GO:0001779
GeneOntologyBiologicalProcess	positive regulation of gamma-delta T cell activation	LILRB1 STAT5A STAT5B	5.58e-05	14	113	3	GO:0046645
GeneOntologyBiologicalProcess	cellular response to cytokine stimulus	EPOR XCR1 LILRA1 LILRA3 TUT4 MUC19 IL20RA LILRB1 STAT5A STAT5B LRP8 GH1 EDAR IRAK4 ABCD4 USP27X	7.44e-05	967	113	16	GO:0071345
GeneOntologyBiologicalProcess	response to cytokine	EPOR XCR1 LILRA1 LILRA3 TUT4 INSR MUC19 IL20RA LILRB1 STAT5A STAT5B LRP8 GH1 EDAR IRAK4 ABCD4 USP27X	8.30e-05	1083	113	17	GO:0034097
GeneOntologyBiologicalProcess	development of secondary male sexual characteristics	STAT5A STAT5B	8.89e-05	3	113	2	GO:0046544
GeneOntologyBiologicalProcess	response to peptide	EPOR XCR1 LILRA1 LILRA3 TUT4 INSR MUC19 IL20RA LILRB1 STAT5A STAT5B LRP8 GH1 EDAR IRAK4 ABCD4 USP27X	1.00e-04	1100	113	17	GO:1901652
GeneOntologyBiologicalProcess	regulation of gamma-delta T cell activation	LILRB1 STAT5A STAT5B	1.03e-04	17	113	3	GO:0046643
GeneOntologyBiologicalProcess	rhythmic process	NPY5R SIX3 STAT5A STAT5B PGR PPP1CA PPP1CB PPP1CC C3orf70	1.65e-04	360	113	9	GO:0048511
GeneOntologyBiologicalProcess	regulation of natural killer cell differentiation	PGLYRP2 STAT5A STAT5B	1.98e-04	21	113	3	GO:0032823
GeneOntologyBiologicalProcess	glycogen metabolic process	INSR ATG2A PPP1CA PPP1CB PPP1CC	2.14e-04	99	113	5	GO:0005977
GeneOntologyBiologicalProcess	glucan metabolic process	INSR ATG2A PPP1CA PPP1CB PPP1CC	2.35e-04	101	113	5	GO:0044042
GeneOntologyCellularComponent	PTW/PP1 phosphatase complex	PPP1CA PPP1CB PPP1CC	5.59e-06	7	115	3	GO:0072357
GeneOntologyCellularComponent	protein phosphatase type 1 complex	PPP1CA PPP1CB PPP1CC	1.47e-04	19	115	3	GO:0000164
Domain	IGc2	PRTG LILRA1 LILRA3 IGFN1 SDK2 DSCAM MYOM3 NFASC LILRB1 HMCN1 ICAM5	1.87e-07	235	113	11	SM00408
Domain	Ig_sub2	PRTG LILRA1 LILRA3 IGFN1 SDK2 DSCAM MYOM3 NFASC LILRB1 HMCN1 ICAM5	1.87e-07	235	113	11	IPR003598
Domain	STPPase_N	PPP1CA PPP1CB PPP1CC	2.16e-07	3	113	3	IPR031675
Domain	STPPase_N	PPP1CA PPP1CB PPP1CC	2.16e-07	3	113	3	PF16891
Domain	Ig-like_fold	EPOR PRTG LILRA1 POGLUT3 LILRA3 IGFN1 SDK2 DSCAM INSR MYOM3 TMIGD3 IL20RA NFASC LILRB1 HMCN1 IGHD ICAM5 CD48	2.34e-07	706	113	18	IPR013783
Domain	ig	LILRA1 LILRA3 SDK2 DSCAM MYOM3 NFASC LILRB1 HMCN1 IGHD ICAM5	2.35e-07	190	113	10	PF00047
Domain	Immunoglobulin	LILRA1 LILRA3 SDK2 DSCAM MYOM3 NFASC LILRB1 HMCN1 IGHD ICAM5	2.35e-07	190	113	10	IPR013151
Domain	-	EPOR PRTG LILRA1 POGLUT3 LILRA3 IGFN1 SDK2 DSCAM INSR MYOM3 TMIGD3 IL20RA NFASC LILRB1 HMCN1 ICAM5 CD48	4.86e-07	663	113	17	2.60.40.10
Domain	Ig-like_dom	PRTG LILRA1 LILRA3 IGFN1 SDK2 DSCAM MYOM3 TMIGD3 NFASC LILRB1 HMCN1 IGHD ICAM5 CD48	2.11e-06	503	113	14	IPR007110
Domain	FN3	EPOR PRTG IGFN1 SDK2 DSCAM INSR MYOM3 IL20RA NFASC	3.39e-06	199	113	9	PS50853
Domain	FN3_dom	EPOR PRTG IGFN1 SDK2 DSCAM INSR MYOM3 IL20RA NFASC	5.06e-06	209	113	9	IPR003961
Domain	fn3	EPOR PRTG IGFN1 SDK2 DSCAM INSR MYOM3 NFASC	6.37e-06	162	113	8	PF00041
Domain	IG_LIKE	PRTG LILRA1 LILRA3 IGFN1 SDK2 DSCAM MYOM3 NFASC LILRB1 HMCN1 IGHD ICAM5 CD48	8.57e-06	491	113	13	PS50835
Domain	IG	PRTG LILRA1 LILRA3 IGFN1 SDK2 DSCAM MYOM3 NFASC LILRB1 HMCN1 ICAM5 CD48	9.33e-06	421	113	12	SM00409
Domain	Ig_sub	PRTG LILRA1 LILRA3 IGFN1 SDK2 DSCAM MYOM3 NFASC LILRB1 HMCN1 ICAM5 CD48	9.33e-06	421	113	12	IPR003599
Domain	FN3	EPOR PRTG IGFN1 SDK2 DSCAM INSR MYOM3 NFASC	1.68e-05	185	113	8	SM00060
Domain	Ig_I-set	PRTG IGFN1 SDK2 DSCAM MYOM3 NFASC HMCN1 ICAM5	2.04e-05	190	113	8	IPR013098
Domain	I-set	PRTG IGFN1 SDK2 DSCAM MYOM3 NFASC HMCN1 ICAM5	2.04e-05	190	113	8	PF07679
Domain	Ser/Thr-sp_prot-phosphatase	PPP1CA PPP1CB PPP1CC	5.90e-05	13	113	3	IPR006186
Domain	SER_THR_PHOSPHATASE	PPP1CA PPP1CB PPP1CC	5.90e-05	13	113	3	PS00125
Domain	PP2Ac	PPP1CA PPP1CB PPP1CC	5.90e-05	13	113	3	SM00156
Domain	Ig_2	LILRA1 LILRA3 LILRB1 ICAM5 CD48	8.03e-05	73	113	5	PF13895
Domain	ADEAMc	ADAD2 ADAT1	5.36e-04	6	113	2	SM00552
Domain	A_deamin	ADAD2 ADAT1	5.36e-04	6	113	2	PF02137
Domain	A_DEAMIN_EDITASE	ADAD2 ADAT1	5.36e-04	6	113	2	PS50141
Domain	A1B_glyco/leuk_Ig-like_rcpt	LILRA1 LILRA3	5.36e-04	6	113	2	IPR016332
Domain	A_deamin	ADAD2 ADAT1	5.36e-04	6	113	2	IPR002466
Domain	Calcineurin-like_PHP_ApaH	PPP1CA PPP1CB PPP1CC	6.33e-04	28	113	3	IPR004843
Domain	Metallophos	PPP1CA PPP1CB PPP1CC	6.33e-04	28	113	3	PF00149
Domain	STAT_TF_prot_interaction	STAT5A STAT5B	7.47e-04	7	113	2	IPR013799
Domain	STAT_TF_DNA-bd_sub	STAT5A STAT5B	7.47e-04	7	113	2	IPR012345
Domain	STAT	STAT5A STAT5B	7.47e-04	7	113	2	IPR001217
Domain	STAT_TF_coiled-coil	STAT5A STAT5B	7.47e-04	7	113	2	IPR015988
Domain	-	STAT5A STAT5B	7.47e-04	7	113	2	2.60.40.630
Domain	STAT_int	STAT5A STAT5B	7.47e-04	7	113	2	SM00964
Domain	STAT_TF_DNA-bd	STAT5A STAT5B	7.47e-04	7	113	2	IPR013801
Domain	STAT_bind	STAT5A STAT5B	7.47e-04	7	113	2	PF02864
Domain	STAT_int	STAT5A STAT5B	7.47e-04	7	113	2	PF02865
Domain	-	STAT5A STAT5B	7.47e-04	7	113	2	1.10.532.10
Domain	STAT_alpha	STAT5A STAT5B	7.47e-04	7	113	2	PF01017
Domain	-	STAT5A STAT5B	7.47e-04	7	113	2	1.20.1050.20
Domain	Metallo-depent_PP-like	PPP1CA PPP1CB PPP1CC	7.77e-04	30	113	3	IPR029052
Domain	-	PPP1CA PPP1CB PPP1CC	7.77e-04	30	113	3	3.60.21.10
Domain	EPL1	JADE2 JADE1	9.92e-04	8	113	2	PF10513
Domain	STAT_TF_alpha	STAT5A STAT5B	9.92e-04	8	113	2	IPR013800
Domain	Enhancer_polycomb-like_N	JADE2 JADE1	9.92e-04	8	113	2	IPR019542
Domain	Carbonic_anhydrase_a-class_CS	CA3 CA8	2.30e-03	12	113	2	IPR018338
Domain	-	POLE PAN2 POLQ	2.88e-03	47	113	3	3.30.420.10
Domain	Carbonic_anhydrase_a-class	CA3 CA8	3.62e-03	15	113	2	IPR023561
Domain	ALPHA_CA_1	CA3 CA8	3.62e-03	15	113	2	PS00162
Domain	ALPHA_CA_2	CA3 CA8	4.65e-03	17	113	2	PS51144
Domain	Carb_anhydrase	CA3 CA8	4.65e-03	17	113	2	PF00194
Domain	Carb_anhydrase	CA3 CA8	4.65e-03	17	113	2	SM01057
Domain	-	CA3 CA8	4.65e-03	17	113	2	3.10.200.10
Domain	Carbonic_anhydrase_a	CA3 CA8	4.65e-03	17	113	2	IPR001148
Pathway	KEGG_MEDICUS_REFERENCE_HORMONE_LIKE_CYTOKINE_TO_JAK_STAT_SIGNALING_PATHWAY	EPOR STAT5A STAT5B GH1	2.27e-06	17	81	4	M47905
Pathway	KEGG_MEDICUS_REFERENCE_GH_JAK_STAT_SIGNALING_PATHWAY	STAT5A STAT5B GH1	6.29e-06	7	81	3	M47646
Pathway	REACTOME_ERYTHROPOIETIN_ACTIVATES_STAT5	EPOR STAT5A STAT5B	6.29e-06	7	81	3	M27907
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_MRAS_SHOC2_PP1_HOLOPHOSPHATASE	PPP1CA PPP1CB PPP1CC	1.00e-05	8	81	3	M47933
Pathway	BIOCARTA_GH_PATHWAY	INSR STAT5A STAT5B GH1	1.61e-05	27	81	4	M9043
Pathway	BIOCARTA_GH_PATHWAY	INSR STAT5A STAT5B GH1	3.65e-05	33	81	4	MM1404
Pathway	KEGG_MEDICUS_REFERENCE_CENPE_INTERACTION_WITH_NDC80_COMPLEX	PPP1CA PPP1CB PPP1CC	3.87e-05	12	81	3	M47887
Pathway	KEGG_MEDICUS_REFERENCE_DEPHOSPHORYLATION_OF_KINETOCHORE	PPP1CA PPP1CB PPP1CC	3.87e-05	12	81	3	M47891
Pathway	WP_JAKSTAT_SIGNALING_IN_THE_REGULATION_OF_BETA_CELLS	EPOR STAT5A STAT5B GH1	4.11e-05	34	81	4	M48081
Pathway	REACTOME_PROLACTIN_RECEPTOR_SIGNALING	STAT5A STAT5B GH1	7.91e-05	15	81	3	M552
Pathway	WP_COMMON_PATHWAYS_UNDERLYING_DRUG_ADDICTION	GRM5 PPP1CA PPP1CB PPP1CC	8.71e-05	41	81	4	M39655
Pathway	REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_RSV_GENOME_REPLICATION_TRANSCRIPTION_AND_TRANSLATION	PPP1CA PPP1CB PPP1CC	9.70e-05	16	81	3	M48235
Pathway	REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING	STAT5A STAT5B GH1	9.70e-05	16	81	3	MM15710
Pathway	BIOCARTA_EPO_PATHWAY	EPOR STAT5A STAT5B	1.66e-04	19	81	3	M12836
Pathway	REACTOME_INTERLEUKIN_20_FAMILY_SIGNALING	IL20RA STAT5A STAT5B	1.94e-04	20	81	3	MM15496
Pathway	BIOCARTA_EPO_PATHWAY	EPOR STAT5A STAT5B	1.94e-04	20	81	3	MM1389
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_JAK_STAT_SIGNALING_PATHWAY	STAT5A STAT5B	3.22e-04	5	81	2	M48987
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_JAK_STAT_SIGNALING_PATHWAY	STAT5A STAT5B	3.22e-04	5	81	2	M48986
Pathway	KEGG_MEDICUS_REFERENCE_PRL_JAK_STAT_SIGNALING_PATHWAY	STAT5A STAT5B	3.22e-04	5	81	2	M49006
Pathway	REACTOME_TRIGLYCERIDE_CATABOLISM	PPP1CA PPP1CB PPP1CC	3.39e-04	24	81	3	M10064
Pathway	REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING	STAT5A STAT5B GH1	3.39e-04	24	81	3	M519
Pathway	REACTOME_SIGNALING_BY_ERYTHROPOIETIN	EPOR STAT5A STAT5B	3.84e-04	25	81	3	M27865
Pathway	REACTOME_INTERLEUKIN_20_FAMILY_SIGNALING	IL20RA STAT5A STAT5B	4.32e-04	26	81	3	M27750
Pathway	REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING	PPP1CA PPP1CB PPP1CC	4.32e-04	26	81	3	M628
Pathway	WP_EPO_RECEPTOR_SIGNALING	EPOR STAT5A STAT5B	4.32e-04	26	81	3	M39687
Pathway	WP_EPO_RECEPTOR_SIGNALING	EPOR STAT5A STAT5B	4.32e-04	26	81	3	MM15896
Pathway	KEGG_OOCYTE_MEIOSIS	PGR PPP1CA PPP1CB PPP1CC CDC27	4.78e-04	113	81	5	M16817
Pathway	REACTOME_INTERLEUKIN_9_SIGNALING	STAT5A STAT5B	4.82e-04	6	81	2	MM15581
Pathway	REACTOME_INTERLEUKIN_21_SIGNALING	STAT5A STAT5B	4.82e-04	6	81	2	MM15621
Pathway	WP_AGERAGE_PATHWAY	INSR STAT5A STAT5B IRAK4	5.56e-04	66	81	4	M39420
Pathway	REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_PATHWAY	MED16 PPP1CA PPP1CB PPP1CC MED26	6.29e-04	120	81	5	M48233
Pathway	REACTOME_STAT5_ACTIVATION	STAT5A STAT5B	6.72e-04	7	81	2	M27953
Pathway	KEGG_MEDICUS_PATHOGEN_HTLV_1_P12_TO_JAK_STAT_SIGNALING_PATHWAY	STAT5A STAT5B	6.72e-04	7	81	2	M47581
Pathway	KEGG_MEDICUS_REFERENCE_EGF_JAK_STAT_SIGNALING_PATHWAY	STAT5A STAT5B	6.72e-04	7	81	2	M47430
Pathway	KEGG_LONG_TERM_POTENTIATION	GRM5 PPP1CA PPP1CB PPP1CC	6.95e-04	70	81	4	M3115
Pathway	PID_EPO_PATHWAY	EPOR STAT5A STAT5B	8.81e-04	33	81	3	M233
Pathway	REACTOME_SIGNALING_BY_MRAS_COMPLEX_MUTANTS	PPP1CB PPP1CC	8.93e-04	8	81	2	M38999
Pathway	REACTOME_INTERLEUKIN_9_SIGNALING	STAT5A STAT5B	1.14e-03	9	81	2	M27861
Pathway	BIOCARTA_IL22BP_PATHWAY	STAT5A STAT5B	1.14e-03	9	81	2	MM1419
Pathway	BIOCARTA_IL22BP_PATHWAY	STAT5A STAT5B	1.14e-03	9	81	2	M8066
Pathway	WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING	INSR GRM5 PPP1CA PPP1CB PPP1CC	1.26e-03	140	81	5	M42572
Pathway	REACTOME_TRIGLYCERIDE_METABOLISM	PPP1CA PPP1CB PPP1CC	1.33e-03	38	81	3	M27856
Pathway	REACTOME_INTERLEUKIN_21_SIGNALING	STAT5A STAT5B	1.42e-03	10	81	2	M27898
Pathway	REACTOME_STAT5_ACTIVATION_DOWNSTREAM_OF_FLT3_ITD_MUTANTS	STAT5A STAT5B	1.42e-03	10	81	2	M41731
Pathway	REACTOME_INTERLEUKIN_2_SIGNALING	STAT5A STAT5B	1.42e-03	10	81	2	MM15618
Pathway	REACTOME_SIGNALING_BY_LEPTIN	STAT5A STAT5B	1.73e-03	11	81	2	M27195
Pathway	REACTOME_INTERLEUKIN_15_SIGNALING	STAT5A STAT5B	1.73e-03	11	81	2	MM15578
Pathway	PID_TCPTP_PATHWAY	INSR STAT5A STAT5B	1.79e-03	42	81	3	M91
Pathway	KEGG_JAK_STAT_SIGNALING_PATHWAY	EPOR IL20RA STAT5A STAT5B GH1	1.97e-03	155	81	5	M17411
Pathway	REACTOME_INTERLEUKIN_2_SIGNALING	STAT5A STAT5B	2.07e-03	12	81	2	M27893
Pathway	KEGG_MEDICUS_REFERENCE_CYTOKINE_JAK_STAT_SIGNALING_PATHWAY	EPOR STAT5A STAT5B	2.18e-03	45	81	3	M47408
Pathway	WP_ENDOPLASMIC_RETICULUM_STRESS_RESPONSE_IN_CORONAVIRUS_INFECTION	PPP1CA PPP1CB PPP1CC	2.32e-03	46	81	3	M39901
Pathway	WP_MAMMARY_GLAND_DEVELOPMENT_PUBERTY_STAGE_2_OF_4	STAT5A PGR	2.44e-03	13	81	2	M39582
Pathway	REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS	PPP1CA PPP1CB PPP1CC	2.47e-03	47	81	3	M646
Pathway	REACTOME_INTERLEUKIN_15_SIGNALING	STAT5A STAT5B	2.84e-03	14	81	2	M27858
Pathway	PID_IL5_PATHWAY	STAT5A STAT5B	2.84e-03	14	81	2	M135
Pubmed	Stat5 is a physiological substrate of the insulin receptor.	INSR STAT5A STAT5B	4.32e-08	3	123	3	9122188
Pubmed	1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription.	PPP1CA PPP1CB PPP1CC	4.32e-08	3	123	3	25073485
Pubmed	Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.	PPP1CA PPP1CB PPP1CC	4.32e-08	3	123	3	21712997
Pubmed	Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia.	EPOR STAT5A STAT5B	4.32e-08	3	123	3	16174761
Pubmed	Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization.	PPP1CA PPP1CB PPP1CC	4.32e-08	3	123	3	7857673
Pubmed	Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein.	PPP1CA PPP1CB PPP1CC	1.72e-07	4	123	3	16131488
Pubmed	Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1.	PPP1CA PPP1CB PPP1CC	1.72e-07	4	123	3	10194355
Pubmed	Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer.	STAT5A STAT5B PGR	1.72e-07	4	123	3	21464042
Pubmed	Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2.	EPOR STAT5A STAT5B	1.72e-07	4	123	3	18239084
Pubmed	Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1.	PPP1CA PPP1CB PPP1CC	1.72e-07	4	123	3	22768081
Pubmed	Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3.	EPOR STAT5A STAT5B	1.72e-07	4	123	3	8977232
Pubmed	Nuclear protein phosphatase-1 regulates HIV-1 transcription.	PPP1CA PPP1CB PPP1CC	1.72e-07	4	123	3	12788939
Pubmed	LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence.	LILRA1 LILRA3 LILRB1	1.72e-07	4	123	3	21559424
Pubmed	Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx.	PPP1CA PPP1CB PPP1CC	1.72e-07	4	123	3	23277204
Pubmed	Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.	PPP1CA PPP1CB PPP1CC	1.72e-07	4	123	3	12226088
Pubmed	N-CoR controls differentiation of neural stem cells into astrocytes.	PPP1CA PPP1CB PPP1CC	1.72e-07	4	123	3	12410313
Pubmed	HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding.	LILRA1 LILRA3 LILRB1	1.72e-07	4	123	3	21270408
Pubmed	Distinct roles for the α , β and γ1 isoforms of protein phosphatase 1 in the outside-in αIIbβ3 integrin signalling-dependent functions.	PPP1CA PPP1CB PPP1CC	4.29e-07	5	123	3	23197154
Pubmed	Dual mechanism of signal transducer and activator of transcription 5 activation by the insulin receptor.	INSR STAT5A STAT5B	4.29e-07	5	123	3	12456798
Pubmed	The heterotrimeric G protein Gβ1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein-coupled receptor signaling in platelets.	PPP1CA PPP1CB PPP1CC	4.29e-07	5	123	3	28615442
Pubmed	Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220.	PPP1CA PPP1CB PPP1CC	4.29e-07	5	123	3	10209101
Pubmed	A PP1-PP2A phosphatase relay controls mitotic progression.	PPP1CA PPP1CB PPP1CC	4.29e-07	5	123	3	25487150
Pubmed	SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1.	PPP1CA PPP1CB PPP1CC	4.29e-07	5	123	3	20424263
Pubmed	Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation.	EPOR STAT5A STAT5B	4.29e-07	5	123	3	32350523
Pubmed	The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity.	PPP1CA PPP1CB PPP1CC	4.29e-07	5	123	3	12016208
Pubmed	Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle.	PPP1CA PPP1CB PPP1CC	4.29e-07	5	123	3	11551964
Pubmed	The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors.	PPP1CA PPP1CB PPP1CC	4.29e-07	5	123	3	17511879
Pubmed	SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1.	PPP1CA PPP1CB PPP1CC	8.57e-07	6	123	3	14640981
Pubmed	Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1).	PPP1CA PPP1CB PPP1CC	8.57e-07	6	123	3	25785436
Pubmed	Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif.	PPP1CA PPP1CB PPP1CC	8.57e-07	6	123	3	21998301
Pubmed	Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3.	PPP1CA PPP1CB PPP1CC	8.57e-07	6	123	3	18641122
Pubmed	A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.	PPP1CA PPP1CB PPP1CC	1.50e-06	7	123	3	12147701
Pubmed	Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality.	PPP1CA PPP1CB PPP1CC	1.50e-06	7	123	3	18689497
Pubmed	SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein.	PPP1CA PPP1CB PPP1CC	1.50e-06	7	123	3	17123353
Pubmed	Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways.	EPOR STAT5A STAT5B	1.50e-06	7	123	3	22086418
Pubmed	Growth-hormone-induced signal transducer and activator of transcription 5 signaling causes gigantism, inflammation, and premature death but protects mice from aggressive liver cancer.	STAT5A STAT5B GH1	1.50e-06	7	123	3	22031092
Pubmed	A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.	LILRA1 LILRA3 LILRB1	2.39e-06	8	123	3	9548455
Pubmed	The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.	PPP1CA PPP1CB PPP1CC	2.39e-06	8	123	3	21930935
Pubmed	A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat.	PPP1CA PPP1CB PPP1CC	2.39e-06	8	123	3	12036313
Pubmed	Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.	PPP1CA PPP1CB PPP1CC	2.39e-06	8	123	3	16262633
Pubmed	The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities.	INSR STAT5A STAT5B	3.57e-06	9	123	3	12237455
Pubmed	Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF.	PPP1CA PPP1CB PPP1CC	3.57e-06	9	123	3	21566083
Pubmed	A systematic scan of interactions with tyrosine motifs in the erythropoietin receptor using a mammalian 2-hybrid approach.	EPOR STAT5A STAT5B	3.57e-06	9	123	3	15644415
Pubmed	RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits.	PPP1CA PPP1CB PPP1CC	3.57e-06	9	123	3	20926688
Pubmed	Skeletal muscle growth and fiber composition in mice are regulated through the transcription factors STAT5a/b: linking growth hormone to the androgen receptor.	STAT5A STAT5B GH1	3.57e-06	9	123	3	19417088
Pubmed	Male-specific hepatic Bcl6: growth hormone-induced block of transcription elongation in females and binding to target genes inversely coordinated with STAT5.	STAT5A STAT5B GH1	3.57e-06	9	123	3	19797429
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ANKRD13D POLE MYOM3 C15orf39 JADE1 EXTL3 ATG2A BIRC6 PLEKHM1 ARHGEF10L PCNX2 CASKIN1 CHPF HECTD1 ADAT1	8.81e-06	1105	123	15	35748872
Pubmed	PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.	PPP1CA PPP1CB PPP1CC	9.28e-06	12	123	3	10830164
Pubmed	Definitive evidence using enucleated cytoplasts for a nongenomic basis for the cystic change in endoplasmic reticulum structure caused by STAT5a/b siRNAs.	STAT5A STAT5B	1.24e-05	2	123	2	23151802
Pubmed	Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.	STAT5A STAT5B	1.24e-05	2	123	2	26999798
Pubmed	Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.	STAT5A STAT5B	1.24e-05	2	123	2	20233708
Pubmed	Involvement of the STAT5 signaling pathway in the regulation of mouse preimplantation development.	STAT5A STAT5B	1.24e-05	2	123	2	16775227
Pubmed	Identification of Stat 5B as a substrate of the insulin receptor.	INSR STAT5B	1.24e-05	2	123	2	9428692
Pubmed	A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions.	STAT5A STAT5B	1.24e-05	2	123	2	31443474
Pubmed	STAT5 isoforms: controversies and clarifications.	STAT5A STAT5B	1.24e-05	2	123	2	17447893
Pubmed	Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.	STAT5A STAT5B	1.24e-05	2	123	2	12377952
Pubmed	A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development.	STAT5A STAT5B	1.24e-05	2	123	2	21127177
Pubmed	The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.	STAT5A STAT5B	1.24e-05	2	123	2	16289657
Pubmed	Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.	STAT5A STAT5B	1.24e-05	2	123	2	25552366
Pubmed	The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases.	PPP1CB PPP1CC	1.24e-05	2	123	2	2544298
Pubmed	Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.	STAT5A STAT5B	1.24e-05	2	123	2	25470773
Pubmed	Constitutively active Stat5A and Stat5B promote adipogenesis.	STAT5A STAT5B	1.24e-05	2	123	2	21431790
Pubmed	Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence.	STAT5A STAT5B	1.24e-05	2	123	2	16115927
Pubmed	Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration.	STAT5A STAT5B	1.24e-05	2	123	2	23275557
Pubmed	Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury.	STAT5A STAT5B	1.24e-05	2	123	2	28500076
Pubmed	STAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen species.	STAT5A STAT5B	1.24e-05	2	123	2	21826656
Pubmed	Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation.	EPOR STAT5A	1.24e-05	2	123	2	8665851
Pubmed	Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation.	STAT5A STAT5B	1.24e-05	2	123	2	11867689
Pubmed	Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.	STAT5A STAT5B	1.24e-05	2	123	2	7720707
Pubmed	Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes.	STAT5A STAT5B	1.24e-05	2	123	2	15980098
Pubmed	STAT5A and STAT5B have opposite correlations with drug response gene expression.	STAT5A STAT5B	1.24e-05	2	123	2	27264955
Pubmed	Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation.	STAT5A STAT5B	1.24e-05	2	123	2	15340066
Pubmed	Stat5 signaling specifies basal versus stress erythropoietic responses through distinct binary and graded dynamic modalities.	EPOR STAT5A	1.24e-05	2	123	2	22969412
Pubmed	Protein phosphatase 1-dependent transcriptional programs for long-term memory and plasticity.	PPP1CB PPP1CC	1.24e-05	2	123	2	20592054
Pubmed	Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function.	STAT5A STAT5B	1.24e-05	2	123	2	22159083
Pubmed	Dephosphorylation activates the interferon-stimulated Schlafen family member 11 in the DNA damage response.	PPP1CC SLFN11	1.24e-05	2	123	2	31395656
Pubmed	Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures.	LILRA1 LILRA3	1.24e-05	2	123	2	11698424
Pubmed	STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.	STAT5A STAT5B	1.24e-05	2	123	2	20008792
Pubmed	STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.	STAT5A STAT5B	1.24e-05	2	123	2	33199496
Pubmed	Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery.	ICAM5 CASKIN1	1.24e-05	2	123	2	30359304
Pubmed	Stat 5B, activated by insulin in a Jak-independent fashion, plays a role in glucokinase gene transcription.	INSR STAT5B	1.24e-05	2	123	2	10830280
Pubmed	STAT5A/B gene locus undergoes amplification during human prostate cancer progression.	STAT5A STAT5B	1.24e-05	2	123	2	23660011
Pubmed	Role of Stat5 in type I interferon-signaling and transcriptional regulation.	STAT5A STAT5B	1.24e-05	2	123	2	12901872
Pubmed	PP-1α and PP-1γ display antagonism and differential roles in tumorigenicity of lung cancer cells.	PPP1CA PPP1CC	1.24e-05	2	123	2	23176181
Pubmed	O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies.	STAT5A STAT5B	1.24e-05	2	123	2	28074064
Pubmed	STAT5b: A master regulator of key biological pathways.	STAT5A STAT5B	1.24e-05	2	123	2	36755813
Pubmed	The influence of STAT5 antisense oligodeoxynucleotides on the proliferation and apoptosis of selected human cutaneous T-cell lymphoma cell lines.	STAT5A STAT5B	1.24e-05	2	123	2	16502315
Pubmed	Stat5: an essential regulator of mast cell biology.	STAT5A STAT5B	1.24e-05	2	123	2	12217382
Pubmed	Identification of isoform-specific dynamics in phosphorylation-dependent STAT5 dimerization by quantitative mass spectrometry and mathematical modeling.	STAT5A STAT5B	1.24e-05	2	123	2	25333863
Pubmed	A role for STAT5 in the pathogenesis of IL-2-induced glucocorticoid resistance.	STAT5A STAT5B	1.24e-05	2	123	2	12421978
Pubmed	A single amino acid in the DNA binding regions of STAT5A and STAT5B confers distinct DNA binding specificities.	STAT5A STAT5B	1.24e-05	2	123	2	9852045
Pubmed	Brain STAT5 Modulates Long-Term Metabolic and Epigenetic Changes Induced by Pregnancy and Lactation in Female Mice.	STAT5A STAT5B	1.24e-05	2	123	2	31599926
Pubmed	Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior.	STAT5A STAT5B	1.24e-05	2	123	2	19966185
Pubmed	Signal transducer and activator of transcription 5a/b: biomarker and therapeutic target in prostate and breast cancer.	STAT5A STAT5B	1.24e-05	2	123	2	21704724
Pubmed	DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.	STAT5A STAT5B	1.24e-05	2	123	2	10594041
Pubmed	Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells.	STAT5A STAT5B	1.24e-05	2	123	2	21036145
Pubmed	Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice.	STAT5A STAT5B	1.24e-05	2	123	2	10486277
Pubmed	Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.	STAT5A STAT5B	1.24e-05	2	123	2	38618957
Pubmed	Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.	STAT5A STAT5B	1.24e-05	2	123	2	16840779
Pubmed	The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.	STAT5A STAT5B	1.24e-05	2	123	2	15128421
Interaction	KIF18A interactions	PPP1CA PPP1CB PPP1CC ICAM5 CDC27 HECTD1	4.04e-07	52	111	6	int:KIF18A
Interaction	PPP1R2C interactions	PPP1CA PPP1CB PPP1CC	6.48e-07	4	111	3	int:PPP1R2C
Interaction	CSRNP2 interactions	PPP1CA PPP1CB PPP1CC	1.61e-06	5	111	3	int:CSRNP2
Interaction	SFRP5 interactions	PPP1CA PPP1CB PPP1CC	3.21e-06	6	111	3	int:SFRP5
Interaction	LILRA3 interactions	LILRA1 LILRA3 LILRB1	2.60e-05	11	111	3	int:LILRA3
Interaction	LILRA1 interactions	LILRA1 LILRA3	3.01e-05	2	111	2	int:LILRA1
Interaction	PPP1R2B interactions	PPP1CA PPP1CB PPP1CC	5.66e-05	14	111	3	int:PPP1R2B
Interaction	SNX17 interactions	TPCN2 PITRM1 INSR IL20RA LRP8	8.50e-05	81	111	5	int:SNX17
Interaction	STAT5A interactions	EPOR INSR STAT5A STAT5B PGR ICAM5	8.71e-05	131	111	6	int:STAT5A
Interaction	CUEDC2 interactions	PGR PPP1CA PPP1CC CDC27	9.12e-05	43	111	4	int:CUEDC2
Cytoband	Ensembl 112 genes in cytogenetic band chr7q11	SPDYE17 SPDYE10 SPDYE9 SPDYE12 SPDYE11 SPDYE13 SPDYE15 SPDYE8 SPDYE14	6.41e-08	271	125	9	chr7q11
Cytoband	7q11.23	SPDYE10 SPDYE9 SPDYE8 SPDYE14	1.49e-04	97	125	4	7q11.23
Cytoband	19p13.3-p13.2	EPOR INSR	6.55e-04	14	125	2	19p13.3-p13.2
Cytoband	19q13.4	LILRA1 LILRA3 LILRB1	1.34e-03	79	125	3	19q13.4
Cytoband	Ensembl 112 genes in cytogenetic band chr17q21	CRHR1 PLEKHM1 STAT5A STAT5B ASB16 CDC27	1.94e-03	473	125	6	chr17q21
Cytoband	10q25.3	NHLRC2 TDRD1	2.85e-03	29	125	2	10q25.3
Cytoband	17q24.2	C17orf58 GH1	3.04e-03	30	125	2	17q24.2
Cytoband	1p34	LRP8 SCMH1	3.46e-03	32	125	2	1p34
Cytoband	16q24.1	LINC00311 ADAD2	3.67e-03	33	125	2	16q24.1
GeneFamily	Fibronectin type III domain containing	EPOR PRTG IGFN1 SDK2 DSCAM INSR MYOM3 NFASC	1.32e-06	160	90	8	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	PRTG IGFN1 SDK2 DSCAM MYOM3 NFASC HMCN1	1.57e-05	161	90	7	593
GeneFamily	Speedy/RINGO cell cycle regulator family	SPDYE9 SPDYE3 SPDYE8	2.54e-05	12	90	3	756
GeneFamily	Protein phosphatase catalytic subunits\|EF-hand domain containing	PPP1CA PPP1CB PPP1CC	3.29e-05	13	90	3	693
GeneFamily	CD molecules\|Activating leukocyte immunoglobulin like receptors	LILRA1 LILRA3	3.63e-04	6	90	2	1181
GeneFamily	Adenosine deaminases acting on RNA	ADAD2 ADAT1	6.73e-04	8	90	2	1303
GeneFamily	Ubiquitin specific peptidases	USP51 PAN2 USP27X	2.73e-03	56	90	3	366
GeneFamily	Immunoglobulin like domain containing	SDK2 DSCAM MYOM3 ICAM5 CD48	2.78e-03	193	90	5	594
GeneFamily	Carbonic anhydrases	CA3 CA8	3.56e-03	18	90	2	460
GeneFamily	DNA polymerases	POLE POLQ	5.79e-03	23	90	2	535
GeneFamily	Ankyrin repeat domain containing	ANKRD13D ACAP1 ASB16 CASKIN1 HECTD1	7.20e-03	242	90	5	403
Disease	glioblastoma (implicated_via_orthology)	POLE USP51 USP27X	4.52e-06	9	113	3	DOID:3068 (implicated_via_orthology)
Disease	COVID-19 symptoms measurement	XCR1 LIMD1 PLEKHM1	3.27e-04	35	113	3	EFO_0600019
Disease	colorectal cancer, hormone replacement therapy	TCAF1 TUT4 INSR LRP8	3.71e-04	88	113	4	EFO_0003961, MONDO_0005575
Disease	Polycythemia	EPOR GH1	4.01e-04	8	113	2	C0032461
Disease	ductal carcinoma in situ (is_marker_for)	KLK10 STAT5A PGR	4.52e-04	39	113	3	DOID:0060074 (is_marker_for)
Disease	Erythrocytosis	EPOR GH1	5.14e-04	9	113	2	C1527405
Disease	axin-2 measurement	MED16 IGHD	6.41e-04	10	113	2	EFO_0801400
Disease	high grade glioma (implicated_via_orthology)	EPOR POLE INSR	6.46e-04	44	113	3	DOID:3070 (implicated_via_orthology)
Disease	Diabetic Asymmetric Polyneuropathy	INSR GRM5	1.28e-03	14	113	2	C0393835
Disease	Diabetic Neuralgia	INSR GRM5	1.28e-03	14	113	2	C0751074
Disease	Diabetic Neuropathies	INSR GRM5	1.28e-03	14	113	2	C0011882
Disease	anemia (is_implicated_in)	EPOR GH1	1.28e-03	14	113	2	DOID:2355 (is_implicated_in)
Disease	Asymmetric Diabetic Proximal Motor Neuropathy	INSR GRM5	1.28e-03	14	113	2	C0271674
Disease	Symmetric Diabetic Proximal Motor Neuropathy	INSR GRM5	1.28e-03	14	113	2	C0271673
Disease	Diabetic Mononeuropathy	INSR GRM5	1.28e-03	14	113	2	C0271678
Disease	Diabetic Autonomic Neuropathy	INSR GRM5	1.28e-03	14	113	2	C0271686
Disease	Diabetic Amyotrophy	INSR GRM5	1.28e-03	14	113	2	C0271685
Disease	Diabetic Polyneuropathies	INSR GRM5	1.28e-03	14	113	2	C0271680
Disease	leukocyte immunoglobulin-like receptor subfamily B member 1 measurement	LILRA1 LILRB1	1.48e-03	15	113	2	EFO_0008208
Disease	hepatic encephalopathy (biomarker_via_orthology)	EPOR INSR	1.48e-03	15	113	2	DOID:13413 (biomarker_via_orthology)
Disease	aggressive behaviour measurement, ADHD symptom measurement	SIX3 GRM5 BIRC6	2.29e-03	68	113	3	EFO_0007826, EFO_0007860
Disease	cognitive function measurement, self reported educational attainment	ZNF184 BIRC6 CRHR1 PLEKHM1 SCMH1 SLC49A3	2.50e-03	355	113	6	EFO_0004784, EFO_0008354
Disease	estrogen-receptor negative breast cancer	POGLUT3 FAM91A1 SPDYE12	2.59e-03	71	113	3	EFO_1000650
Disease	COVID-19, osteoarthritis	XCR1 LIMD1	2.64e-03	20	113	2	MONDO_0005178, MONDO_0100096
Disease	Endometrial Carcinoma	POLE PGR SULT2B1	2.69e-03	72	113	3	C0476089
Disease	cancer (implicated_via_orthology)	ACAP1 POLE PPP1CA PPP1CB PPP1CC	3.77e-03	268	113	5	DOID:162 (implicated_via_orthology)
Disease	Alcoholic Intoxication, Chronic	LILRA1 NPY5R CRHR1 LRP8 GH1	3.77e-03	268	113	5	C0001973

Protein segments in the cluster

Peptide	Gene	Start	Entry
GVKPSLGIWTPEAIC	TDRD1	611	Q9BXT4
PVACSLGLSGEWVPT	LINC00311	66	Q8N616
TLGLPLELLECVSWP	nan	91	Q8N976
LELLECVSWPLCGSP	nan	96	Q8N976
SFTTPPCEECIVWLL	CA3	196	P07451
LLWECPVGDILPNSS	DCAF17	101	Q5H9S7
EPTPDTCRGLSLNWS	ADAD2	476	Q8NCV1
VLWDLESPPVCLTVG	ARHGEF10L	956	Q9HCE6
NLCGCDEPLSSVWVP	ANKRD13D	426	Q6ZTN6
IPTCGDLASLSIDIW	BIRC6	1806	Q9NR09
LGLELPLSCQEVLWP	DPM3	26	Q9P2X0
LGVLAVVCPDEWPLL	ALDH16A1	661	Q8IZ83
VVCPDEWPLLAFVSL	ALDH16A1	666	Q8IZ83
APWSALPCGLLLDEL	DUX4L4	361	P0CJ87
VPSCETWVEAVLPEL	ASB16	376	Q96NS5
PAPEWASINLGVTLC	ACAP1	426	Q15027
PSLSPAACWIDVLGR	DNHD1	1631	Q96M86
CEILGESEWGLDTPP	ABCD4	361	O14678
PESSWEPDECTLLSP	C3orf70	221	A6NLC5
EVLECLWPRGTSEPE	ATG2A	521	Q2TAZ0
LVPCGAAISWSAVPE	ADAT1	391	Q9BUB4
PDCLVIIWDSFTGIP	CFAP251	321	Q8TBY9
PATITIETCEDPGDW	GMEB2	211	Q9UKD1
LPEIAWISTLPFCGS	OR6K2	156	Q8NGY2
IGTASWSDPCLPELP	NOBOX	591	O60393
WKELGSPEGVLVCPS	PAN2	786	Q504Q3
AAEISGLSIPDWLPE	CASKIN1	526	Q8WXD9
SWPTDDLTGCDLIPV	GRM5	556	P41594
ADPFSITPGIWVACI	LAMA3	836	Q16787
LPELSCKEGPLGWSS	LIMD1	396	Q9UGP4
FWLLCLIVGSSPEAP	C17orf58	6	Q2M2W7
SLCADILEWAGVVPP	EDAR	426	Q9UNE0
TEADWVPLELCFGIP	FAM91A1	716	Q658Y4
PCWSPEEESSLLPGF	CARMIL3	1106	Q8ND23
VSCALWIPEVSIGCP	JADE2	276	Q9NQC1
WGSENSVLIPEPVSC	PCNX2	276	A6NKB5
PALDSVGCPERITWL	ICAM5	491	Q9UMF0
EDWSISVELRPCPSG	MUC19	846	Q7Z5P9
LGAWSLNATELDPCP	PGLYRP2	71	Q96PD5
NATCVEPTELTGWPI	LRRC52	211	Q8N7C0
PLELDTDGIWCVLPN	POLE	856	Q07864
CGSNSWTVVDIDPPL	INSR	551	P06213
SPECLWEEGKEVIPT	PLEKHA8	296	Q96JA3
LLPSAESPVCWLEQP	MED26	331	O95402
ELEVSCWPTLVILGP	NHLRC2	156	Q8NBF2
DWDPQTGRLCIPSLS	IL20RA	481	Q9UHF4
LECEARGIPAPSLTW	HMCN1	2031	Q96RW7
LTCEASGIPLPSITW	HMCN1	2406	Q96RW7
IPSLDWLPASDGLVS	MED16	726	Q9Y2X0
LLSPLPGVWCFSELS	PRTG	26	Q2VWP7
VTSSWCLFGPELPED	PGR	136	P06401
PDQGLLCDLLWSDPD	PPP1CA	196	P62136
PTDVPDTGLLCDLLW	PPP1CB	191	P62140
LECIASGVPTPDIAW	NFASC	266	O94856
LSPPCSNWVETGLEV	BTBD18	626	B2RXH4
EPLALASGALPDWCE	HECTD1	2051	Q9ULT8
WTLTLALPREACGPL	GRID2IP	176	A4D2P6
FLVWPKCGPISDTLL	DMRT2	341	Q9Y5R5
PSLPTEWALCGERED	EXTL3	406	O43909
VACWLLDPDSQEPTL	POLQ	1991	O75417
SLTIPPCSEGVTWIL	CA8	221	P35219
WLLCEVSGFSPPNIL	IGHD	291	P01880
GCLPQPEGTAWALDL	C16orf90	91	A8MZG2
ASVDLIGTCWPRSPA	CRHR1	46	P34998
DPPASLEVLSERCWG	EPOR	326	P19235
LIGCLPPLFGWSSVE	GPR161	156	Q8N6U8
WQLVEEIPEGCSTPD	IGFN1	16	Q86VF2
LDRLSCLDGTPPLSW	IRAK4	271	Q9NWZ3
LSPPCTLARSFGVEW	CD48	211	P09326
LACETSGAPRPAITW	SDK2	421	Q58EX2
PFLWSPFESLCEIGE	CDC27	146	P30260
EWSAPSDPLDILITG	LILRA3	306	Q8N6C8
SFDRPLWAEPCLGET	LRP8	896	Q14114
LWAEPCLGETREPED	LRP8	901	Q14114
ECEELKSCPWLSLPG	PRR14L	271	Q5THK1
LWPDVPLECIVSLGT	PNPLA8	646	Q9NP80
PCVVVSGDLPITITW	DSCAM	616	O60469
NEWTLTPLALSGLCP	PLEKHM1	186	Q9Y4G2
CEDDITCGPTWLPLS	RTBDN	126	Q9BSG5
WLLDGQPCSSEFLPI	TRMT5	401	Q32P41
AVTPELCPDVTIWGV	SMYD4	476	Q8IYR2
APWCETIVGAFSLPD	SULT2B1	101	O00204
VPETPLDCEVSLWSS	SPON2	271	Q9BUD6
TSWDVPEDAVPCELL	TCAF1	16	Q9Y4C2
SLPAVLTLGSPEWEE	TOGARAM2	456	Q6ZUX3
EWSAPSDPLDILIAG	LILRA1	306	O75019
EWSAPSDPLDILIAG	LILRB1	306	Q8NHL6
ATVWTLGFAICSPLP	NPY5R	161	Q15761
GGDPLCIPELTWEQL	PITRM1	236	Q5JRX3
LAPEPEETWVAETLC	SPDYE10	76	P0DUX0
LAPEPEETWVAETLC	SPDYE11	76	P0DTA3
LAPEPEETWVAETLC	SPDYE8	76	P0DUD1
FLWSLPVAPGACEAI	SIX3	111	O95343
CIVPAWLPSLPDEVF	SHROOM1	376	Q2M3G4
IPTGCLEVFPEAEWS	SLFN11	756	Q7Z7L1
GPPEGSLDVLQSWCE	STAT5B	266	P51692
DLSLLELEWPIQCPG	PROZ	261	P22891
SCALWIPEVSIGSPE	JADE1	281	Q6IE81
EILWDLPCSIMGSPL	SCMH1	11	Q96GD3
SPSCTLGLVLPLWSD	SSH3	156	Q8TE77
GPPEGSLDVLQSWCE	STAT5A	266	P42229
LQAPLWPSSLGITDC	ANGEL1	476	Q9UNK9
ESLSPSGCLLWDVPA	ATF6B	201	Q99941
LSLLSVTWVEEPCGP	CHPF	26	Q8IZ52
DVDWTLATGPLLPSA	C15orf39	156	Q6ZRI6
PSLSTCQQGEDPLDW	SLC49A3	406	Q6UXD7
PIPIISWCGSLDSRD	POGLUT3	256	Q7Z4H8
SDLVFACLLPVWISP	XCR1	76	P46094
TTIDPCWDISLDLPG	USP51	506	Q70EK9
TTIDPCWDISLDLPG	USP27X	221	A6NNY8
LAPEPEETWVAETLC	SPDYE12	76	P0DUX1
LAPEPEETWVAETLC	SPDYE13	76	A0A494C0Z2
LAPEPEETWVAETLC	SPDYE14	76	P0DUD3
LAPEPEETWVAETLC	SPDYE15	76	P0DUD4
LAPEPEETWVAETLC	SPDYE17	76	P0DUD2
LAPEPEETWVAETLC	SPDYE3	141	A6NKU9
PEPEETWVAETLCGL	SPDYE3	216	A6NKU9
APEPEETWVAETLCG	SPDYE3	361	A6NKU9
SPCTLPSGEAGIIWD	PIEZO2	1401	Q9H5I5
LCLPWLQEGSAFPTI	GH1	16	P01241
PDQGLLCDLLWSDPD	PPP1CC	196	P36873
SEVLLGQLCSPEPDW	UNQ6494/PRO21346	96	Q6UXR6
LPLPTSVACELWGQG	ZSWIM8	1596	A7E2V4
LAPEPEETWVAETLC	SPDYE9	76	A0A494C191
PLDGTELCIWNTKDP	WDR27	46	A2RRH5
EVSVPPGALDCWVFL	TRAPPC10	346	P48553
EEQPDWTLGCLSPES	TMIGD3	21	P0DMS9
PLLPCLLGSWIEGFD	TUT4	536	Q5TAX3
APWEPPCGLTESVEV	TPCN2	116	Q8NHX9
PSIPVGTCADWETRL	ZNF184	91	Q99676
GPLVCDETLQGILSW	KLK10	231	O43240
LPASEAETVLCVWPG	LRRC26	221	Q2I0M4
CIVSGDPTPEISWLK	MYOM3	1356	Q5VTT5