Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionclathrin binding

PIK3C2A CLTC

2.59e-0363242GO:0030276
MousePhenoabnormal platelet alpha-granule number

PIK3C2A AGBL4

1.07e-055152MP:0020429
MousePhenodecreased platelet alpha-granule number

PIK3C2A AGBL4

1.07e-055152MP:0020431
MousePhenoabnormal platelet alpha-granule morphology

PIK3C2A AGBL4

3.85e-059152MP:0014060
MousePhenoabnormal platelet shape

PIK3C2A AGBL4

4.81e-0510152MP:0003405
DomainKinase-like_dom

PRKD3 PIK3C2A EIF2AK4 DYRK4

4.00e-03542234IPR011009
DomainZnf_RING

RNF17 MARCHF4 UNKL

7.20e-03326233IPR001841
DomainSer/Thr_kinase_AS

PRKD3 EIF2AK4 DYRK4

9.24e-03357233IPR008271
DomainS_TKc

PRKD3 EIF2AK4 DYRK4

9.38e-03359233SM00220
DomainPROTEIN_KINASE_ST

PRKD3 EIF2AK4 DYRK4

9.59e-03362233PS00108
DomainProtein_kinase_ATP_BS

PRKD3 EIF2AK4 DYRK4

1.09e-02379233IPR017441
DomainPkinase

PRKD3 EIF2AK4 DYRK4

1.10e-02381233PF00069
DomainPROTEIN_KINASE_ATP

PRKD3 EIF2AK4 DYRK4

1.81e-02459233PS00107
DomainProt_kinase_dom

PRKD3 EIF2AK4 DYRK4

2.14e-02489233IPR000719
PathwayWP_COMPLEMENT_AND_COAGULATION_CASCADES

CR1 F5 CLTC

4.31e-0558173M39649
PathwayWP_DENGUE2_INTERACTIONS_WITH_COMPLEMENT_AND_COAGULATION_CASCADES

CR1 F5 CLTC

4.54e-0559173M48343
Pubmed

Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.

PRKD3 PIK3C2A

9.51e-05212429446795
Pubmed

Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.

PIK3C2A CLTC

1.05e-042224226950368
Pubmed

HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.

PRKD3 PIK3C2A

1.05e-042224211154208
Pubmed

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.

PIK3C2A CLTC

1.47e-042624224067654
Pubmed

The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.

PIK3C2A EIF2AK4 CLTC

5.21e-0423024335449600
Pubmed

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.

F5 CLTC

5.48e-045024224769233
GeneFamilyGlycosyltransferase family 6|Blood group antigens

CR1 GCNT2

4.21e-0437152454
GeneFamilyRing finger proteins

RNF17 MARCHF4

2.12e-0227515258
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TMEM178B MARCHF4 AGBL4 F5

1.84e-06167244c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCellCerebellum-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Gfap)|Cerebellum / BrainAtlas - Mouse McCarroll V32

RNF17 ERV3-1 SFMBT2

3.00e-051132437e24c0f6a80e10a2a41325d48a87628bd330a1e2
ToppCellCerebellum-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Gfap)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

RNF17 ERV3-1 SFMBT2

3.00e-05113243c0b8d7a2e3722029e850051bdff77f31f34a8cca
ToppCellCerebellum-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Gfap)--|Cerebellum / BrainAtlas - Mouse McCarroll V32

RNF17 ERV3-1 SFMBT2

3.00e-05113243fed408864201218295bac0cc6647953fda8d688e
ToppCellfacs-Liver-Non-hepatocytes-3m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF17 AGBL4 EIF2AK4

7.26e-05152243b61d2f6ee819c8dd4b4b601a8bc8388b1983de58
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CR1 F5 SFMBT2

7.70e-05155243e7f49e2fdaf184fa6b4e685518004e7deff1316d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CR1 F5 SFMBT2

7.70e-051552435a872ca70ae8c30b57f45a6772d7bf565e0c2663
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CR1 F5 SFMBT2

7.70e-0515524390e629681a72baacc7981b82883866a487638dbc
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

TMEM178B MARCHF4 AGBL4

9.10e-05164243be49af6335f2505065cde2cb9800e4a5516811b1
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)|Children_(3_yrs) / Lineage, Cell type, age group and donor

TMEM178B MARCHF4 AGBL4

9.94e-05169243b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCell5'-Adult-LargeIntestine-Epithelial-neuro-epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MARCHF4 AGBL4 F5

1.08e-041742439f114e61458659005b6d0b4aa30a7a059e7aa5c6
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

PIK3C2A ATG10 UPF1

1.10e-04175243f3a68aeb79c4935006e17a5ff3445a8ec0e33f5f
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)|Adult / Lineage, Cell type, age group and donor

TMEM178B MARCHF4 F5

1.10e-041752434db1a3c284488b3f6de7568363f176d74e2a4587
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231|Adult / Lineage, Cell type, age group and donor

TMEM178B MARCHF4 F5

1.10e-041752438d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

TMEM178B MARCHF4 AGBL4

1.24e-0418224357bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell3'-Adult-LargeIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MARCHF4 AGBL4 SFMBT2

1.26e-0418324349f3ddc1c7c04b4ca837dbd6dad995add82941d6
ToppCellCOVID-19-kidney-Podocyte|kidney / Disease (COVID-19 only), tissue and cell type

CR1 F5 SFMBT2

1.26e-04183243fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CR1 F5 SFMBT2

1.26e-041832433c516fe5083f02bad1f464ed284010b4131a833c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CR1 F5 SFMBT2

1.26e-041832437c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CR1 F5 SFMBT2

1.26e-04183243612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CR1 F5 SFMBT2

1.26e-04183243eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CR1 F5 SFMBT2

1.26e-041832439c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CR1 F5 SFMBT2

1.28e-041842437294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TMEM178B MARCHF4 AGBL4

1.32e-04186243b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TMEM178B MARCHF4 AGBL4

1.36e-04188243c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

AGBL4 EDN3 GCNT2

1.45e-04192243d3634574b2e8d2ded6446969361b70761b331aea
ToppCellPCW_13-14-Epithelial-Epithelial_proliferating|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

AGBL4 EDN3 GCNT2

1.54e-041962437b17d47b7758d8ccf9dbefd097aeb553791a1eed
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CR1 SFMBT2 DYRK4

1.59e-041982436a4161680b46b2c12353a693c403b5a4bb3da03f
ToppCellCOVID_vent|World / Disease condition, Lineage, Cell class and subclass

CR1 F5 CLTC

1.63e-042002431d88e5cc4534073f27a7562e1c4b884bd67f09d9
DiseaseAntithrombotic agent use measurement

F5 HECTD4

9.17e-0455242EFO_0009925
Diseasevenous thromboembolism, fibrinogen measurement

F5 HECTD4

1.36e-0367242EFO_0004286, EFO_0004623

Protein segments in the cluster

PeptideGeneStartEntry
MTKTLLYHTYYECAG

ERV3-1

41

Q14264
TTEAVHYLYIQMEYC

EIF2AK4

791

Q9P2K8
HYLYIQMEYCEKSTL

EIF2AK4

796

Q9P2K8
SEVIKYEYHVLYSCS

ATG10

91

Q9H0Y0
LSRYICEMTLQEYHY

CCNB3

1281

Q8WWL7
EATCYEYMVRSHYVT

GCNT2

71

Q8N0V5
TETHTLALYETCEKY

LCN9

131

Q8WX39
AYDHYVAICKPLSYT

OR4X2

111

Q8NGF9
VSNYEKYYLICSLSH

PIK3C2A

701

O00443
TLYVHSYKAPTFCDY

PRKD3

156

O94806
TSCHYKVELSYENFI

HECTD4

2206

Q9Y4D8
DTYYTKDLPIHACSY

UPF1

111

Q92900
FGSSCYEHQKVYTYI

DYRK4

251

Q9NR20
YMCSLSLFHYSEYLV

ICMT

96

O60725
KVYHYGDYVTLKCED

CR1

1926

P17927
TYKDKECVYYCHLDI

EDN3

101

P14138
LDHTSYCYTLEVSFY

AGBL4

391

Q5VU57
ELCYYKYHVIAISTK

MARCHF4

206

Q9P2E8
SHLTVVCMYYTAVFY

OR13A1

261

Q8NGR1
ERCTYIKYHYSSATI

TMEM178B

131

H3BS89
AKHYLKSCYTTEFYV

F5

1981

P12259
YIHLYDLETGTCIYM

CLTC

281

Q00610
AYYKYCTSEHTEEML

RNF17

1351

Q9BXT8
ENCSIHTKTKYTYYY

SFMBT2

651

Q5VUG0
YHLRYYKTGTCIHET

UNKL

111

Q9H9P5