Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvolume-sensitive anion channel activity

LRRC8C TTYH2

7.29e-059292GO:0005225
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC24A5 ANO1 KCNK5 LRRC8C LRP6 STRA6 SLC44A4 TTYH2

2.04e-041180298GO:0022857
GeneOntologyMolecularFunctiontransporter activity

SLC24A5 ANO1 KCNK5 LRRC8C LRP6 STRA6 SLC44A4 TTYH2

3.73e-041289298GO:0005215
GeneOntologyMolecularFunctionintracellularly calcium-gated channel activity

ANO1 TTYH2

3.81e-0420292GO:0141147
GeneOntologyMolecularFunctionintracellularly calcium-gated chloride channel activity

ANO1 TTYH2

3.81e-0420292GO:0005229
GeneOntologyMolecularFunctionmonoatomic anion channel activity

ANO1 LRRC8C TTYH2

4.42e-04103293GO:0005253
GeneOntologyMolecularFunctionmonoatomic ion channel activity

SLC24A5 ANO1 KCNK5 LRRC8C TTYH2

4.73e-04459295GO:0005216
GeneOntologyMolecularFunctionsialic acid binding

SIGLEC14 SIGLEC5

5.98e-0425292GO:0033691
GeneOntologyMolecularFunctionchannel activity

SLC24A5 ANO1 KCNK5 LRRC8C TTYH2

8.68e-04525295GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

SLC24A5 ANO1 KCNK5 LRRC8C TTYH2

8.76e-04526295GO:0022803
GeneOntologyMolecularFunctionvitamin transmembrane transporter activity

STRA6 SLC44A4

1.24e-0336292GO:0090482
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

ANO1 LRRC8C TTYH2

1.34e-03151293GO:0008509
GeneOntologyMolecularFunctionligand-gated monoatomic anion channel activity

ANO1 TTYH2

2.39e-0350292GO:0099095
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC24A5 ANO1 KCNK5 LRRC8C TTYH2

5.24e-03793295GO:0015075
GeneOntologyMolecularFunctionchloride channel activity

ANO1 TTYH2

6.90e-0386292GO:0005254
GeneOntologyCellularComponentDNA polymerase complex

POLE2 PRIM1

3.24e-0420282GO:0042575
MousePhenoabnormal eosinophil differentiation

SIGLEC14 SIGLEC5

1.55e-054232MP:0002443
DomainIg/MHC_CS

SIGLEC14 SIGLEC5

3.65e-0358292IPR003006
DomainIG_MHC

SIGLEC14 SIGLEC5

3.90e-0360292PS00290
DomainTPR-contain_dom

CRNKL1 TTC28

2.26e-02150292IPR013026
PathwayREACTOME_DNA_REPLICATION_INITIATION

POLE2 PRIM1

7.73e-058242M27664
PathwayREACTOME_DNA_REPLICATION_INITIATION

POLE2 PRIM1

7.73e-058242MM15367
Pubmed

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.

SIGLEC14 SIGLEC5

7.19e-07230224799499
Pubmed

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.

SIGLEC14 SIGLEC5

7.19e-07230226459514
Pubmed

Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model.

SIGLEC14 SIGLEC5

2.16e-06330224698729
Pubmed

Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters.

SIGLEC14 SIGLEC5

2.16e-06330211579105
Pubmed

Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.

SIGLEC14 SIGLEC5

2.16e-06330217012248
Pubmed

Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages.

SIGLEC14 SIGLEC5

2.16e-06330231520477
Pubmed

Antiallergic effect of anti-Siglec-F through reduction of eosinophilic inflammation in murine allergic rhinitis.

SIGLEC14 SIGLEC5

2.16e-06330223710953
Pubmed

Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling.

SIGLEC14 SIGLEC5

2.16e-06330219783675
Pubmed

Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in Mice.

SIGLEC14 SIGLEC5

2.16e-06330230577572
Pubmed

A novel Siglec-F+ neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model.

SIGLEC14 SIGLEC5

2.16e-06330232247614
Pubmed

Frontline Science: Superior mouse eosinophil depletion in vivo targeting transgenic Siglec-8 instead of endogenous Siglec-F: Mechanisms and pitfalls.

SIGLEC14 SIGLEC5

2.16e-06330232134149
Pubmed

Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.

SIGLEC14 SIGLEC5

2.16e-06330225497369
Pubmed

Siglec-F is a novel intestinal M cell marker.

SIGLEC14 SIGLEC5

2.16e-06330227524237
Pubmed

Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity.

SIGLEC14 SIGLEC5

4.31e-06430217562860
Pubmed

Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.

SIGLEC14 SIGLEC5

4.31e-06430217272508
Pubmed

Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors.

SIGLEC14 SIGLEC5

4.31e-06430219178537
Pubmed

Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.

SIGLEC14 SIGLEC5

4.31e-06430233289969
Pubmed

Induction of Siglec-FhiCD101hi eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection.

SIGLEC14 SIGLEC5

4.31e-06430237251384
Pubmed

IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils.

SIGLEC14 SIGLEC5

4.31e-06430233976385
Pubmed

Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis.

SIGLEC14 SIGLEC5 MGST3

4.41e-063730332732898
Pubmed

Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs.

SIGLEC14 SIGLEC5

7.18e-06530220395633
Pubmed

Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13.

SIGLEC14 SIGLEC5

7.18e-06530221040544
Pubmed

Siglec-F-expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis.

SIGLEC14 SIGLEC5

7.18e-06530235482420
Pubmed

Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue.

SIGLEC14 SIGLEC5

1.08e-05630223880769
Pubmed

DNA primase from KB cells. Characterization of a primase activity tightly associated with immunoaffinity-purified DNA polymerase-alpha.

POLE2 PRIM1

1.08e-0563026693436
Pubmed

Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G).

SIGLEC14 SIGLEC5

1.08e-05630214559209
Pubmed

[Functions and molecular evolution of Siglecs, a family of sialic acid receptor proteins].

SIGLEC14 SIGLEC5

1.51e-05730218453149
Pubmed

Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice.

SIGLEC14 SIGLEC5

1.51e-05730223677475
Pubmed

The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils.

SIGLEC14 SIGLEC5

1.51e-05730215048729
Pubmed

Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen.

SIGLEC14 SIGLEC5

1.51e-05730223840825
Pubmed

Selective Response to Bacterial Infection by Regulating Siglec-E Expression.

SIGLEC14 SIGLEC5

3.94e-051130232889432
Pubmed

A mouse knockout library for secreted and transmembrane proteins.

SIGLEC14 SIGLEC5 PLVAP STRA6 SLC44A4

4.30e-0546030520562862
Pubmed

CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder.

SIGLEC14 SIGLEC5

5.58e-051330235921817
Pubmed

Canonical WNT signaling components in vascular development and barrier formation.

LRP6 PLVAP

6.50e-051430225083995
Pubmed

Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization.

SIGLEC14 SIGLEC5

9.70e-051730235709757
Pubmed

Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.

SIGLEC14 SIGLEC5

1.96e-042430215331780
Pubmed

Deficiency of MFSD7c results in microcephaly-associated vasculopathy in Fowler syndrome.

LRP6 PLVAP

2.68e-042830232369449
Pubmed

A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting.

SIGLEC14 SIGLEC5

2.88e-042930233567267
Pubmed

Defining the membrane proteome of NK cells.

LRRC8C XRN2 CERS6 DCP1B MGST3 PRIM1

4.21e-04116830619946888
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

CRNKL1 XRN2 TTC28 TRIP12

6.78e-0446930427634302
Cytoband6p21

KCNK5 GLP1R

6.02e-04572926p21
CytobandEnsembl 112 genes in cytogenetic band chr2q24

FAP CERS6

2.94e-03127292chr2q24
CytobandEnsembl 112 genes in cytogenetic band chr6p21

KCNK5 SLC44A4 GLP1R

3.87e-03503293chr6p21
CytobandEnsembl 112 genes in cytogenetic band chr20p11

CRNKL1 XRN2

4.22e-03153292chr20p11
GeneFamilyCD molecules|C2-set domain containing|Sialic acid binding Ig like lectins

SIGLEC14 SIGLEC5

3.89e-0428192745
GeneFamilyAdenosine receptors|V-set domain containing

SIGLEC14 SIGLEC5

1.25e-02163192590
CoexpressionCHICAS_RB1_TARGETS_GROWING

ANO1 FAP CERS6 POLE2 PRIM1

6.38e-06242295M2128
CoexpressionGSE15330_HSC_VS_MEGAKARYOCYTE_ERYTHROID_PROGENITOR_DN

LMBR1 LRP6 TTC28 ARID4A

3.41e-05168294M7007
CoexpressionGSE28737_BCL6_HET_VS_BCL6_KO_MARGINAL_ZONE_BCELL_UP

FAP STRA6 SLC44A4 TTC28

6.73e-05200294M9348
CoexpressionGSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN

KCNK5 LRRC8C STRA6 TRIP12

6.73e-05200294M9549
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_B|E18.5-samps / Age Group, Lineage, Cell class and subclass

LRRC8C PLVAP DCP1B GLP1R

4.23e-06163304d6f9b7280c44d120df5a72dfc2ebb26ffbb5752b
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_activated|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SIGLEC14 SIGLEC5 MAS1 POLE2

9.30e-061993043b2bd3caf4d189a1726a737b0121860b265eec04
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Tmem163_Arhgap25|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

STRA6 SLC44A4 MAS1

6.61e-05117303e1a14b8413a6f4b194217a90eb2c5f95ab14522e
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Gkn1_Pcdh19|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FAP SLC44A4 MAS1

1.22e-04144303e8caeb6485f4c8f9a3384570dc69024c2bcc9ab0
ToppCelldroplet-Heart-4Chambers-18m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLVAP SLC44A4 TTYH2

1.35e-0414930338890ddde0979977c8350f01497f1245ab51641a
ToppCellfacs-Lung-EPCAM-3m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLVAP GLP1R TTYH2

1.55e-04156303bb64bf520cb74897a01c64924a85a1550df2b801
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLVAP GLP1R PRIM1

1.58e-041573032c946c6ab284fac3c25db688ed0aabe5a3f9ffa5
ToppCellChildren_(3_yrs)-Immune-dendritic_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CERS6 PLVAP TTYH2

1.73e-0416230386a0b9dabd150dc993bfc0f3344804de7f8e4042
ToppCelllung-Club_Cells|lung / shred on tissue and cell subclass

ANO1 CERS6 PRIM1

1.80e-04164303b12cacd499b18b96120ca6d14646aebeaed41d10
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRRC8C PLVAP MAS1

1.83e-041653036a621b300442c52adfc15b61d3a6d3a3cb00099f
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell-mesothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANO1 FAP STRA6

1.89e-041673031adb566f98af0109c8cc6e36033b89651e2c75e7
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANO1 FAP STRA6

1.89e-04167303743df5908c1ceb43b34b240d9f9649f30f4142fa
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 MMD2 SLC44A4

1.93e-04168303100ab6d36592b61f4db9f8cb90c48afac016d679
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-7|TCGA-Lung / Sample_Type by Project: Shred V9

KCNK5 SLC44A4 GANC

1.96e-041693035f522a10b6ec24a353f53bec2f779a81cd5f9581
ToppCellcontrol-Myeloid-Monocyte-derived_Macrophage|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SIGLEC14 LRRC8C TTYH2

2.03e-04171303e828b684744a4fdf6b63ec033c4f000b39ca0d51
ToppCellfacs-Limb_Muscle-Muscle_Diaphragm-18m-Endothelial-new-cluster|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIGLEC5 PLVAP GLP1R

2.07e-041723032fcc6278ead890019a6505fb4fcb518751262dda
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KCNK5 PLVAP TTYH2

2.10e-0417330312f779b8dce79431b2d1002ba524dd3f9566aeb0
ToppCellNS-control-d_0-4-Myeloid-Monocyte-derived_Macrophage|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SIGLEC14 LRRC8C TTYH2

2.14e-04174303758984730cd1c3ccf6866a3a8f03d6e002f3edb6
ToppCellAdult-Epithelial-lung_goblet_cell-D231|Adult / Lineage, Cell type, age group and donor

ANO1 STRA6 SLC44A4

2.14e-041743037d2f802f493f19a068e097b2909a9000e2160266
ToppCellfacs-Heart-RV-24m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 MGST3 TTYH2

2.17e-04175303bfac175b79bb7d3d81074a2407c206a7647ee75d
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Neuron|GW19 / Sample Type, Dataset, Time_group, and Cell type.

FAP GANC TTYH2

2.17e-041753032812ac2ef41d245db544697fb6da1883361c96e8
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_ductal_cel|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNK5 MMD2 SLC44A4

2.17e-041753038902c38067f025b094ca9c28c449c32a66eded1c
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNK5 MMD2 SLC44A4

2.17e-041753036bb8fc2959583644f16b22e906af91af62a3a633
ToppCellfacs-Heart-RV-24m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 MGST3 TTYH2

2.17e-04175303c94fb35bbac95123201ca87ca835aecaefc0c490
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLVAP GLP1R PRIM1

2.21e-04176303269326c2bf44a9003d95bc6dbc839f08f25737ca
ToppCelldroplet-Pancreas-Exocrine-24m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNK5 MMD2 SLC44A4

2.25e-04177303a5b54792ef948a1e1de66301a60e051250189f59
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANO1 FAP STRA6

2.36e-04180303935c091bbcd6d10b81dc4731779e5bd98205c99f
ToppCell5'-Airway_Nasal-Mesenchymal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANO1 FAP STRA6

2.36e-041803033dd384b7f3d9582b8fec9fe05100e466e6218b76
ToppCell3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRRC8C FAP PLVAP

2.36e-04180303efc4c5a4dea456527526bbfd88cf70d803893671
ToppCellfacs-SCAT|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNK5 FAP TTYH2

2.36e-041803036c70b6b7480507fa94625013222ad338ee7dd1d9
ToppCellfacs-Heart-RA-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 MGST3 MAS1

2.40e-04181303429df38438d5a7ff490c9ede34b69e2970c7ded2
ToppCell18-Airway-Epithelial-Submucosal_gland_basal|Airway / Age, Tissue, Lineage and Cell class

ANO1 KCNK5 STRA6

2.40e-0418130333938e6521712058312879f84f4ae381c2bfc379
ToppCellfacs-Heart-RA-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 MGST3 MAS1

2.40e-04181303395cf5aa2d89b05328ab516b8c89401020b6d830
ToppCellfacs-Heart-LV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 FAP TTYH2

2.40e-041813031db1eb7d330a7e5090994007ae287e11f0a74450
ToppCellfacs-Heart-LV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 FAP TTYH2

2.40e-0418130306174ce9240c9261c0f51a1b0d875335d60722e5
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial|E18.5-samps / Age Group, Lineage, Cell class and subclass

LRRC8C PLVAP GLP1R

2.44e-041823037af3b2029b7f55b923d5a4b764d4292f4ea48599
ToppCellE18.5-samps-Endothelial|E18.5-samps / Age Group, Lineage, Cell class and subclass

LRRC8C PLVAP GLP1R

2.44e-04182303e2d799e6e7526176a6fe6515b8fbe4d83d3a3ea1
ToppCelldroplet-Limb_Muscle-nan-21m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 STRA6 MGST3

2.48e-041833036f5dbac2748f50105f0f548d189c42ef14287019
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANO1 FAP STRA6

2.48e-041833036d98973098c6d20c5305bce6a83a549a7d8dbfba
ToppCellfacs-Heart-LA-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 MGST3 MAS1

2.48e-041833038d45dff06a199b1369576657f7f9dc0249c5f841
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANO1 FAP STRA6

2.48e-04183303cc7f5a17b40e8d901885174922e5fa8877643071
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANO1 FAP STRA6

2.48e-04183303803376f5260de83c48d4f7301278d078a32b3e6e
ToppCellfacs-Heart-LA-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 MGST3 MAS1

2.48e-04183303421265fa15d5a028cb567bb0904e670473ef102b
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNK5 MMD2 SLC44A4

2.52e-0418430310706441e7695212f95689414f31e8082b5eaf0a
ToppCell(7)_DC_activated|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

CERS6 STRA6 TTYH2

2.52e-04184303b89871a3e36fde6daa68daf116f8c8d587554c0f
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNK5 MMD2 SLC44A4

2.52e-041843034bb0976a75126ad2b3deb5d2229f0716fafe200e
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 MGST3 MAS1

2.56e-0418530330df02fbe2828e3c4f3e5c4cda855e74fb31be39
ToppCellControl-Myeloid-DC_Mature|Myeloid / Disease state, Lineage and Cell class

KCNK5 CERS6 TTYH2

2.60e-04186303e9e58c5871b4966cd3586b611703e21af8df6360
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-2|TCGA-Kidney / Sample_Type by Project: Shred V9

ANO1 FAP TTYH2

2.60e-041863031e6526fc9e9381b7ace864588cc7bd80194338d6
ToppCellfacs-Heart-LA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 FAP TTYH2

2.64e-04187303a12f383b02b07af32cc53a154685df8dba8fbd3f
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 MGST3 MAS1

2.64e-041873038ff9f771d10c372d771c92dfa9006aa81aec4681
ToppCellfacs-Heart-LA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 FAP TTYH2

2.64e-04187303c40c152fa14e6afc9188549534b64ccbaded56b3
ToppCell5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRRC8C FAP PLVAP

2.68e-04188303524d1d928c9386acf20e53d31894107dd7290dc7
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 MMD2 SLC44A4

2.68e-04188303842982de2197770f999a70083ed9fca40ac22d79
ToppCell5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRRC8C FAP PLVAP

2.68e-04188303f5a2f324f3f6c5078d57130392d3f1ba74f29094
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 MMD2 SLC44A4

2.68e-04188303a0815eaf68eedd6e5ec4af520df80a6ab4eb0864
ToppCelldroplet-Heart-HEART-1m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNK5 SIGLEC5 MMD2

2.68e-04188303921a2c9212a0f2a00fd72c594d80924f27e8b9b7
ToppCell5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRRC8C FAP PLVAP

2.68e-041883031b57995d70cf81212e8d46dfaf44dbaf9c7bc4d5
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FAP MGST3 GLP1R

2.68e-04188303c2321a3a1d9603f8b4b4fc09707eb32ec1e04f3f
ToppCell5'-Airway_Nasal-Endothelial-Blood_vessel_EC|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRRC8C FAP PLVAP

2.68e-04188303cd2d1f8e43c252dd8730a5758458ef63e7ffc836
ToppCell5'-Airway_Nasal-Endothelial|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRRC8C FAP PLVAP

2.68e-041883036c9d5e4014f807149328ff4eabd5e86dfe18094d
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 KCNK5 MMD2

2.85e-04192303f3133bbbf938a39062a9b1d1181003bb48174695
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

LRP6 XRN2 TTC28

2.85e-04192303916fbec1c7ab7969bda711886ac88e877e30c280
ToppCellfacs-Heart-LA-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLVAP STRA6 GLP1R

2.85e-0419230314a816ef116aa992f86edab411f043cf7d07fe04
ToppCellCOPD-Myeloid-DC_Mature|Myeloid / Disease state, Lineage and Cell class

KCNK5 CERS6 TTYH2

2.85e-04192303baebd462f464e7d0e462d07a74bb5d685a9fc3b6
ToppCellfacs-Thymus-Flowthrough-3m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNK5 POLE2 PRIM1

2.85e-04192303e8d47504b744040a762ec9b670a66cc060b2ae86
ToppCellfacs-Heart-LA-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLVAP STRA6 GLP1R

2.85e-04192303847822514d747a21d5eb40e04ba9a023fd32bd65
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1|TCGA-Endometrium / Sample_Type by Project: Shred V9

LMBR1 CERS6 PRIM1

2.90e-04193303c2673d86f7d7b849788036032a93a6d136a70040
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 STRA6 MGST3

2.94e-0419430352ecec2618c3bb5fdd7fb06b5a40bd6f0aedfe1d
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC28 GLP1R TTYH2

2.99e-04195303bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC28 GLP1R TTYH2

2.99e-0419530358b769da05a8f6b05aeb08d4f8b112941087ad00
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 STRA6 MGST3

2.99e-041953030bdf845939bc4b8cc94f2808aea60f818425b076
ToppCellBronchial-10x5prime-Epithelial-Epi_alveolar-Dividing_AT2|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SLC24A5 KCNK5 POLE2

3.08e-0419730349689a03ab31e53386dbe15c77c09ca3a14ebf4e
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CERS6 STRA6 POLE2

3.12e-0419830328ada093cec552262731194a04a4b9ff93186c3b
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANO1 FAP STRA6

3.12e-04198303eb78b2ae6a787dbc75947e8dd5a03693285bc8be
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANO1 FAP STRA6

3.12e-041983038b9e8eaeffda40912a0163fdf39b93bc5e64751c
ToppCellCF-Myeloid-Monocyte_Macrophage|CF / Disease state, Lineage and Cell class

CERS6 MGST3 TTYH2

3.17e-04199303bf95eacb31a4a847350f9d6e95ca76c6b730c400
Diseasedolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 measurement

SIGLEC14 SIGLEC5

4.18e-0510292EFO_0801544
Diseasesialic acid-binding Ig-like lectin 14 measurement

SIGLEC14 SIGLEC5

6.12e-0512292EFO_0008284
Diseasemean corpuscular hemoglobin concentration

KCNK5 SIGLEC5 XRN2 CERS6 TTC28 ARID4A PRIM1

7.67e-051105297EFO_0004528
Diseasemigraine disorder, diastolic blood pressure

KCNK5 ARID4A

2.76e-0425292EFO_0006336, MONDO_0005277
Diseaselymphocyte count

LMBR1 LRRC8C SIGLEC5 FAP CERS6 TTC28 TRIP12

4.34e-041464297EFO_0004587
Diseasecups of coffee per day measurement

STRA6 SLC44A4

7.11e-0440292EFO_0006782
Diseasewaist-hip ratio

KCNK5 DCP1B TTC28 ARID4A TRIP12 PRIM1

1.06e-031226296EFO_0004343
Diseasesusceptibility to cold sores measurement

ANO1 SLC44A4

1.87e-0365292EFO_0008402
Diseaseage at menopause

SLC44A4 TTC28 PRIM1

3.19e-03302293EFO_0004704
Diseasehypertension

KCNK5 CERS6 SLC44A4

3.34e-03307293EFO_0000537
DiseaseVitiligo

FAP SLC44A4

4.43e-03101292EFO_0004208
Diseasevon Willebrand factor measurement, coronary artery disease

KCNK5 MAS1

6.00e-03118292EFO_0001645, EFO_0004629
Diseasehypertension (implicated_via_orthology)

MAS1 GLP1R

7.02e-03128292DOID:10763 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
VLYLVHYYGWNVRYD

ARID4A

606

P29374
LYVCPVYWAYDYALR

POLE2

456

P56282
GAGTHYYAIWRYLYL

MMD2

246

Q8IY49
YYAIWRYLYLPSTLQ

MMD2

251

Q8IY49
LLYLLYYEYWSTFGN

MAS1

246

P04201
YYWLLVEGVYLYTLL

GLP1R

241

P43220
SLYDLWEFYLPYLYS

LMBR1

181

Q8WVP7
CWYYLRYFFLFVSLI

PLVAP

21

Q9BX97
ALYRYFVELWIYLGL

KCNK5

221

O95279
RERYGLLPYWYSLFY

GANC

671

Q8TET4
PYDLSIDIYSRYIYW

LRP6

1016

O75581
LYEEWARYGVFYKYQ

ANO1

301

Q5XXA6
LAWIVGRVLYAYGYY

MGST3

91

O14880
YYRRLFPYSQYYRWL

PRIM1

16

P49642
LYRNARLSIYGIWFY

DCP1B

101

Q8IZD4
TISAARLYYYWERDY

APOBEC3F

116

Q8IUX4
KRYIYLWINYALYEE

CRNKL1

531

Q9BZJ0
TDLHYYYILELSFYW

CERS6

176

Q6ZMG9
YGIYYCWEEYRVLRD

SLC44A4

271

Q53GD3
YYFTYDSWTGKVLYL

SATL1

601

Q86VE3
LYVYWFRDGEIPYYA

SIGLEC5

56

O15389
WKILGLFYYAALYYP

STRA6

146

Q9BX79
LWRYSYTATYYIYDL

FAP

121

Q12884
GYVEYYRWLSYLLLF

TTYH2

206

Q9BSA4
SYVEGLCWVLRYYYQ

XRN2

541

Q9H0D6
YWYEGALLLLIYGLY

SLC24A5

196

Q71RS6
VLYYSLAAGYLYSWL

TTC28

1236

Q96AY4
RVLHAISRYWYYLYD

TRIP12

1476

Q14669
LYVYWFRDGEIPYYA

SIGLEC14

56

Q08ET2
YTLYWLFYRSLREYS

LRRC8C

336

Q8TDW0