Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nodal binding	CFC1 CFC1B	1.64e-04	8	49	2	GO:0038100
GeneOntologyMolecularFunction	activin receptor binding	CFC1 CFC1B	5.27e-04	14	49	2	GO:0070697
GeneOntologyBiologicalProcess	neurotransmitter receptor transport postsynaptic membrane to endosome	LRRC7 SCRIB	3.31e-05	4	49	2	GO:0098968
GeneOntologyBiologicalProcess	left lung morphogenesis	CFC1 CFC1B	3.31e-05	4	49	2	GO:0060460
GeneOntologyBiologicalProcess	left lung development	CFC1 CFC1B	5.50e-05	5	49	2	GO:0060459
MousePheno	total anomalous pulmonary venous connection, intracardiac	CFC1 CFC1B	7.98e-06	2	40	2	MP:0010443
MousePheno	unbalanced complete common atrioventricular canal	CFC1 CFC1B	4.77e-05	4	40	2	MP:0011673
MousePheno	total anomalous pulmonary venous connection	CFC1 CFC1B	4.77e-05	4	40	2	MP:0010441
MousePheno	superior-inferior ventricles	CFC1 CFC1B	1.66e-04	7	40	2	MP:0011254
Domain	TF_fork_head_CS_2	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	1.27e-07	46	49	5	IPR030456
Domain	TF_fork_head_CS_1	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	1.42e-07	47	49	5	IPR018122
Domain	FORK_HEAD_3	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	1.76e-07	49	49	5	PS50039
Domain	FH	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	1.76e-07	49	49	5	SM00339
Domain	FORK_HEAD_1	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	1.76e-07	49	49	5	PS00657
Domain	FORK_HEAD_2	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	1.76e-07	49	49	5	PS00658
Domain	Forkhead	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	1.76e-07	49	49	5	PF00250
Domain	Fork_head_dom	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	1.76e-07	49	49	5	IPR001766
Domain	CFC	CFC1 CFC1B	2.02e-05	3	49	2	PF09443
Domain	Cryptic/Cripto_CFC-dom	CFC1 CFC1B	2.02e-05	3	49	2	IPR019011
Domain	-	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	2.60e-04	218	49	5	1.10.10.10
Domain	WHTH_DNA-bd_dom	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	4.20e-04	242	49	5	IPR011991
Domain	PDZ	LRRC7 SCRIB PARD3 PRX	5.07e-04	141	49	4	PF00595
Domain	PDZ	LRRC7 SCRIB PARD3 PRX	6.08e-04	148	49	4	SM00228
Domain	-	LRRC7 SCRIB PARD3 PRX	6.39e-04	150	49	4	2.30.42.10
Domain	PDZ	LRRC7 SCRIB PARD3 PRX	6.56e-04	151	49	4	PS50106
Domain	PDZ	LRRC7 SCRIB PARD3 PRX	6.72e-04	152	49	4	IPR001478
Domain	-	CTDP1 POLL	1.65e-03	23	49	2	3.40.50.10190
Domain	BRCT	CTDP1 POLL	2.11e-03	26	49	2	PS50172
Domain	BRCT_dom	CTDP1 POLL	2.44e-03	28	49	2	IPR001357
Domain	HMGI/Y_DNA-bd_CS	YTHDC1 ZBTB24	2.99e-03	31	49	2	IPR000637
Domain	FBOX	FBXO31 FBXO27	8.22e-03	52	49	2	SM00256
Pubmed	Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	4.06e-14	6	53	5	27092474
Pubmed	The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	3.78e-13	8	53	5	8530406
Pubmed	An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	8.49e-13	9	53	5	12412011
Pubmed	A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	8.63e-12	13	53	5	16884697
Pubmed	Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	8.63e-12	13	53	5	7957066
Pubmed	Six members of the mouse forkhead gene family are developmentally regulated.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	2.01e-11	15	53	5	7689224
Pubmed	Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	2.01e-11	15	53	5	22045912
Pubmed	FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.	FOXD4L4 FOXD4L6 FOXD4L5 FOXD4	2.40e-11	5	53	4	12234674
Pubmed	Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	2.92e-11	16	53	5	8861101
Pubmed	Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	2.92e-11	16	53	5	10208738
Pubmed	Functional equivalency between Otx2 and Otx1 in development of the rostral head.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	7.75e-11	19	53	5	9895322
Pubmed	Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	1.03e-10	20	53	5	12812790
Pubmed	Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	1.35e-10	21	53	5	9449667
Pubmed	Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	1.75e-10	22	53	5	17389379
Pubmed	Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	2.82e-10	24	53	5	11820816
Pubmed	A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	2.82e-10	24	53	5	29992973
Pubmed	Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	4.35e-10	26	53	5	15857913
Pubmed	Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	7.82e-10	29	53	5	22972626
Pubmed	Genome-scale study of transcription factor expression in the branching mouse lung.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	6.09e-08	67	53	5	22711520
Pubmed	Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions.	FOXD4L4 FOXD4L3 FOXD4	5.47e-07	11	53	3	12421752
Pubmed	The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer.	CFC1 CFC1B	2.28e-06	2	53	2	11174844
Pubmed	Identification of differentially expressed genes in mouse development using differential display and in situ hybridization.	CFC1 CFC1B	2.28e-06	2	53	2	11327798
Pubmed	Subtractive hybridization identifies chick-cripto, a novel EGF-CFC ortholog expressed during gastrulation, neurulation and early cardiogenesis.	CFC1 CFC1B	2.28e-06	2	53	2	11024280
Pubmed	Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects.	CFC1 CFC1B	2.28e-06	2	53	2	11062482
Pubmed	Diverse fates of paralogs following segmental duplication of telomeric genes.	FOXD4L4 FOXD4L3 FOXD4	5.04e-06	22	53	3	15233989
Pubmed	KAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity by protecting the RNA m6A reader YTHDC1 protein degradation.	TRIM28 YTHDC1	6.83e-06	3	53	2	38745192
Pubmed	Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs.	CFC1 CFC1B	6.83e-06	3	53	2	16835440
Pubmed	Role of the polarity protein Scribble for podocyte differentiation and maintenance.	SCRIB PARD3	6.83e-06	3	53	2	22586490
Pubmed	Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.	FOXD4L4 FOXD4L3 COQ4 FOXD4L6 FOXD4L5 FOXD4	7.16e-06	306	53	6	18973680
Pubmed	Cripto in tumors and embryo development.	CFC1 CFC1B	1.36e-05	4	53	2	11825688
Pubmed	The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation.	SCRIB PARD3	1.36e-05	4	53	2	28095473
Pubmed	Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1.	CFC1 CFC1B	1.36e-05	4	53	2	9576836
Pubmed	TRIM28 Is an E3 Ligase for ARF-Mediated NPM1/B23 SUMOylation That Represses Centrosome Amplification.	CDKN2A TRIM28	1.36e-05	4	53	2	26055329
Pubmed	Role of the EGF-CFC gene cripto in cell differentiation and embryo development.	CFC1 CFC1B	1.36e-05	4	53	2	11992720
Pubmed	MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.	CDKN2A TRIM28	2.27e-05	5	53	2	16107876
Pubmed	A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation.	CFC1 CFC1B	2.27e-05	5	53	2	9053319
Pubmed	Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb.	CFC1 CFC1B	2.27e-05	5	53	2	25224222
Pubmed	A role of the cryptic gene in the correct establishment of the left-right axis.	CFC1 CFC1B	3.40e-05	6	53	2	10574770
Pubmed	Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway.	CFC1 CFC1B	3.40e-05	6	53	2	12052855
Pubmed	GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth.	CFC1 CFC1B	3.40e-05	6	53	2	17991893
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SCAP VWA8 KCNG1 TRIM28 COQ4 CTDP1 POLL MBD6 LYST	4.02e-05	1105	53	9	35748872
Pubmed	Scribble1 plays an important role in the pathogenesis of neural tube defects through its mediating effect of Par-3 and Vangl1/2 localization.	SCRIB PARD3	4.76e-05	7	53	2	28369449
Pubmed	Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation.	CFC1 CFC1B	4.76e-05	7	53	2	10521397
Pubmed	Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos.	CFC1 CFC1B	4.76e-05	7	53	2	19906859
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5 FOXD4	5.08e-05	263	53	5	20932939
Pubmed	Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos.	CFC1 CFC1B	6.34e-05	8	53	2	21419113
Pubmed	Two nodal-responsive enhancers control left-right asymmetric expression of Nodal.	CFC1 CFC1B	6.34e-05	8	53	2	15736223
Pubmed	Left-right patterning of the mouse lateral plate requires nodal produced in the node.	CFC1 CFC1B	8.15e-05	9	53	2	12654299
Pubmed	Left-asymmetric expression of Galanin in the linear heart tube of the mouse embryo is independent of the nodal co-receptor gene cryptic.	CFC1 CFC1B	8.15e-05	9	53	2	18773496
Pubmed	Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo.	CFC1 CFC1B	1.02e-04	10	53	2	17913787
Pubmed	Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway.	CFC1 CFC1B	1.24e-04	11	53	2	15475956
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	TRIM28 AJM1 LRRC7	1.49e-04	67	53	3	29254152
Pubmed	BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment.	CFC1 CFC1B	1.76e-04	13	53	2	18550712
Pubmed	Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.	CFC1 CFC1B	2.05e-04	14	53	2	17210915
Pubmed	Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves.	SCRIB PARD3	2.36e-04	15	53	2	20237282
Pubmed	Scribble mutation disrupts convergent extension and apical constriction during mammalian neural tube closure.	SCRIB PARD3	2.36e-04	15	53	2	34029538
Pubmed	Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density.	ADGRB1 LRRC7	2.36e-04	15	53	2	23782696
Pubmed	Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse.	CFC1 CFC1B	2.36e-04	15	53	2	12361961
Pubmed	Rab23 regulates Nodal signaling in vertebrate left-right patterning independently of the Hedgehog pathway.	CFC1 CFC1B	2.36e-04	15	53	2	24780629
Pubmed	The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier.	SCRIB PARD3	2.36e-04	15	53	2	28536193
Pubmed	PDZ-Containing Proteins Targeted by the ACE2 Receptor.	SCRIB PARD3	2.36e-04	15	53	2	34835087
Pubmed	Maternal Cripto is critical for proper development of the mouse placenta and the placental vasculature.	CFC1 CFC1B	2.36e-04	15	53	2	33730615
Pubmed	Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells.	CFC1 CFC1B	2.36e-04	15	53	2	17360443
Pubmed	Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity.	SCRIB PARD3	2.70e-04	16	53	2	32460029
Pubmed	TBX1 regulates epithelial polarity and dynamic basal filopodia in the second heart field.	SCRIB PARD3	2.70e-04	16	53	2	25371366
Pubmed	Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner.	CFC1 CFC1B	3.05e-04	17	53	2	18697220
Pubmed	Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate.	CFC1 CFC1B	3.05e-04	17	53	2	19716815
Pubmed	Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo.	CFC1 CFC1B	3.05e-04	17	53	2	22627279
Pubmed	Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development.	CFC1 CFC1B	3.43e-04	18	53	2	17936261
Pubmed	Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of ATRIP-Seckel syndrome.	ATRIP TRIM28	3.43e-04	18	53	2	32994318
Pubmed	Tcf3: a transcriptional regulator of axis induction in the early embryo.	CFC1 CFC1B	3.43e-04	18	53	2	14668413
Pubmed	Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis.	CFC1 CFC1B	3.43e-04	18	53	2	20346354
Pubmed	SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.	SCRIB PARD3	3.83e-04	19	53	2	21965329
Pubmed	ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis.	SCRIB PARD3	3.83e-04	19	53	2	35177595
Pubmed	αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development.	SCRIB PARD3	3.83e-04	19	53	2	27405641
Pubmed	Biochemical and Cellular Analysis Reveals Ligand Binding Specificities, a Molecular Basis for Ligand Recognition, and Membrane Association-dependent Activities of Cripto-1 and Cryptic.	CFC1 CFC1B	3.83e-04	19	53	2	28126904
Pubmed	Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering.	PLSCR3 LYST	3.83e-04	19	53	2	9070936
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SCAP OBSL1 SCRIB ZBTB24	3.90e-04	225	53	4	12168954
Pubmed	Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node.	CFC1 CFC1B	4.25e-04	20	53	2	11517919
Pubmed	Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node.	CFC1 CFC1B	4.25e-04	20	53	2	11440720
Pubmed	Wnt3a links left-right determination with segmentation and anteroposterior axis elongation.	CFC1 CFC1B	4.70e-04	21	53	2	16291790
Pubmed	Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo.	CFC1 CFC1B	5.16e-04	22	53	2	18241853
Pubmed	E3 ubiquitin ligase NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7.	CDKN2A TRIM28	5.16e-04	22	53	2	35792897
Pubmed	New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity.	SCRIB PARD3	5.65e-04	23	53	2	18809908
Pubmed	SOX9-COL9A3-dependent regulation of choroid plexus epithelial polarity governs blood-cerebrospinal fluid barrier integrity.	SCRIB PARD3	5.65e-04	23	53	2	33526661
Pubmed	Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.	CFC1 CFC1B	5.65e-04	23	53	2	14623818
Pubmed	Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse.	CFC1 CFC1B	6.16e-04	24	53	2	18171685
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	LRRC7 PLSCR3 SCRIB PARD3	7.00e-04	263	53	4	34702444
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	FOXD4L4 FOXD4L3 TRIM28 FOXD4L6 FOXD4L5 FOXD4	7.15e-04	709	53	6	22988430
Pubmed	Endogenous Nodal signaling regulates germ cell potency during mammalian testis development.	CFC1 CFC1B	7.23e-04	26	53	2	23034635
Pubmed	The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo.	CFC1 CFC1B	7.23e-04	26	53	2	23651855
Pubmed	Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.	TRIM28 OBSL1	8.40e-04	28	53	2	25752541
Pubmed	Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast.	CFC1 CFC1B	8.40e-04	28	53	2	11412024
Pubmed	Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent.	CDKN2A BEX4	1.03e-03	31	53	2	36656901
Pubmed	α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.	SCRIB PARD3	1.31e-03	35	53	2	37381005
Pubmed	Host PDZ-containing proteins targeted by SARS-CoV-2.	LRRC7 PARD3	1.31e-03	35	53	2	33864728
Pubmed	Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects.	CFC1 CFC1B	1.39e-03	36	53	2	27606604
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CDKN2A EPC2 VWA8 TRIM28 OBSL1 SCRIB PARD3	1.46e-03	1116	53	7	31753913
Cytoband	9q21.11	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5	4.24e-08	30	53	4	9q21.11
Cytoband	8q24.3	ADGRB1 SCRIB ZNF707	3.11e-04	113	53	3	8q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr9q21	FOXD4L4 FOXD4L3 FOXD4L5	1.60e-03	199	53	3	chr9q21
Cytoband	2q21.1	CFC1 CFC1B	2.07e-03	58	53	2	2q21.1
GeneFamily	PDZ domain containing	LRRC7 SCRIB PARD3 PRX	9.68e-05	152	29	4	1220
GeneFamily	Cyclins\|F-boxes other	FBXO31 FBXO27	1.77e-03	39	29	2	560
Coexpression	MORI_MATURE_B_LYMPHOCYTE_UP	FOXD4L4 FOXD4L3 FOXD4L6 YTHDC1 FOXD4L5 FOXD4	7.46e-08	106	53	6	MM595
ToppCell	wk_15-18-Hematologic-Myeloid-aDC_1\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FOXD4L4 FOXD4L3 FOXD4L6 FBXO27 FOXD4L5 FOXD4	6.71e-08	177	53	6	ccf5dc54780d6039a4d062dee88440c011ddc0a3
ToppCell	wk_20-22-Hematologic-Myeloid-aDC_1\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	FOXD4L4 FOXD4L3 FOXD4L6 FBXO27 FOXD4	2.25e-06	178	53	5	fd2bdb4796e86c8cff2d25f0c730ffea21db8787
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FOXD4L4 FOXD4L3 FBXO27 FOXD4L5 FOXD4	2.38e-06	180	53	5	32d871738a24071b70084a7e80148a516110c78b
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FOXD4L4 FOXD4L3 FBXO27 FOXD4L5 FOXD4	2.38e-06	180	53	5	067ca8a15228c7f3b3bc7aecbc9b1611ca05e176
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	BRWD1-AS2 GPR135 PARD3 NOL8	2.75e-05	146	53	4	cffa91d76606f74553d81150adbb23b003746316
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	BRWD1-AS2 GPR135 PARD3 NOL8	3.31e-05	153	53	4	e7d20c88466ff81db613869cf7a6a4bb95fd6c2f
ToppCell	facs-Marrow-KLS-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDKN2A ERMAP MAFB SMOX	3.75e-05	158	53	4	0edd9b005875f9a4f5446f5d5161f8ba63860793
ToppCell	facs-Marrow-KLS-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDKN2A ERMAP MAFB SMOX	3.75e-05	158	53	4	9fd77ebdd1babf1c85a85d38d9a15858ab08bc84
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	COQ4 ERMAP HSD11B1L ZNF707	4.34e-05	164	53	4	d6806deabf5f5c355934387be2baae125ac33fb8
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-Myeloid-Lymphoid_DC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXD4L4 FOXD4L3 FOXD4L6 FOXD4	4.76e-05	168	53	4	6dd58fd981750da49afd53796f244e1803cce97f
ToppCell	VE-matDC-\|VE / Condition, Cell_class and T cell subcluster	FOXD4L6 FBXO27 FAM20A FOXD4	6.36e-05	181	53	4	6252184ef098b911df50be4fe1b5565849a5b6b8
ToppCell	VE-matDC\|VE / Condition, Cell_class and T cell subcluster	FOXD4L6 FBXO27 FAM20A FOXD4	6.36e-05	181	53	4	982fd96ef75bc9ab2c2f4970c01b76ba7a164871
ToppCell	megakaryocytic-Platelet\|megakaryocytic / Lineage and Cell class	VWA8 PARD3 SMOX LINC02915	6.92e-05	185	53	4	436f0ab9016c5b8b7315d5974de80af6b3a999d2
Disease	double outlet right ventricle (implicated_via_orthology)	CFC1 CFC1B	6.82e-06	3	45	2	DOID:6406 (implicated_via_orthology)
Disease	right atrial isomerism (implicated_via_orthology)	CFC1 CFC1B	1.36e-05	4	45	2	DOID:0060856 (implicated_via_orthology)
Disease	dextro-looped transposition of the great arteries (implicated_via_orthology)	CFC1 CFC1B	1.36e-05	4	45	2	DOID:0060770 (implicated_via_orthology)
Disease	NEURAL TUBE DEFECTS, SUSCEPTIBILITY TO	SCRIB PARD3	6.33e-05	8	45	2	C3891448
Disease	visceral heterotaxy (is_implicated_in)	CFC1 CFC1B	1.49e-04	12	45	2	DOID:0050545 (is_implicated_in)
Disease	glioblastoma (is_implicated_in)	CDKN2A ADGRB1	6.14e-04	24	45	2	DOID:3068 (is_implicated_in)
Disease	visceral heterotaxy (implicated_via_orthology)	CFC1 CFC1B	1.46e-03	37	45	2	DOID:0050545 (implicated_via_orthology)
Disease	spleen volume	CDKN2A MAFB	1.97e-03	43	45	2	EFO_0600047

Protein segments in the cluster

Peptide	Gene	Start	Entry
GGCVRPARPERRLRS	CTDP1	71	Q9Y5B0
TVPRRCIGFARRRIG	EPC2	441	Q52LR7
LPCGARRTGPRRPVR	BRWD1-AS2	96	P59051
PGGNIRRGRVRRLVP	BEX4	46	Q9NWD9
GRGFRDRTRTCRPPQ	ADGRB1	426	O14514
PVLPRRGREAQRAAR	AJM1	111	C9J069
IRRACGPPRVRVFVV	CDKN2A	11	Q8N726
ARERGVRGTQPCPRI	LINC00528	31	Q8N1L1
VLQRERRPCGRPGLG	CFC1B	206	P0CG36
VPRVRRLCRGLARPH	HSD11B1L	296	Q7Z5J1
VLQRERRPCGRPGLG	CFC1	206	P0CG37
VCRLPGPGRRHRRLD	POLL	476	Q9UGP5
GRRGPQKRGVRVLRP	TSPOAP1	1591	O95153
RPLRPGARVRIRQEG	OBSL1	1756	O75147
VPPGVVRKSRRGRRR	MBD6	941	Q96DN6
LGRAERPGRPCTRLQ	MAFB	36	Q9Y5Q3
GRRPLIRQDRIVGVP	LRRC7	806	Q96NW7
ERGCPLPRAPRGRRR	KCNK4	356	Q9NYG8
ERVQGLRRVCPRPRG	FOXD4L4	336	Q8WXT5
ERVQGLRRICPRPRG	FOXD4L3	336	Q6VB84
GPSRGCRRRQQRRGP	FBXO31	11	Q5XUX0
CGARRPLRVRLADPG	PLSCR3	131	Q9NRY6
EPRQGCQPEDRRRRI	KCNG1	51	Q9UIX4
KGRVREPRVSRRRPG	LMNTD2	511	Q8IXW0
PLRPRLCRLVRGEQG	SLC9A3R2	6	Q15599
GLRRGRQCIRPAEIV	NOL8	531	Q76FK4
GERVQGLRRVCPRPR	FOXD4	331	Q12950
CAIVRPPREKIGRRR	GPR135	211	Q8IZ08
RPVLRRLCGLPGLQR	COQ4	6	Q9Y3A0
VLEIRRRPPRRGGCA	C17orf50	121	Q8WW18
PTEGPNRERRRLQRC	LYST	2951	Q99698
VRRAGGPPRTDQQRR	ATRIP	701	Q8WXE1
ARRPIGRNLIRNPCG	FBXO27	106	Q8NI29
GPEPRVVRRRGLQRS	FAM110C	186	Q1W6H9
GDCLTRIPRPGRQRR	SCAP	806	Q12770
PRPRIIRGRGCNESF	PARD3	911	Q8TEW0
DQRCVRLGDRRQPVP	ERMAP	256	Q96PL5
GRLGQRQVRRRPPVL	RTL5	536	Q5HYW3
RRRRCVLLGPVAPAA	NKX1-1	96	Q15270
VQRQLRPRERPRGCP	FAM20A	31	Q96MK3
ERVQGLRRVCPRPRG	FOXD4L5	336	Q5VV16
ERVQGLRRVCPRPRG	FOXD4L6	336	Q3SYB3
LCSSRRPVRPGRRGL	SCRIB	1611	Q14160
ALERRPRRQGRPRGC	NOXO1	351	Q8NFA2
PPGVRRQSVRAGRVR	ACOT4	131	Q8N9L9
GGRRPQRAEPQRICR	LINC02915	11	Q8N8G6
QVLTQRCGRRPGRRE	ZNF707	151	Q96C28
RCRRGRIGVQPSPER	nan	16	Q9BTK2
RGRVRVRLPRVGLAA	PRX	1371	Q9BXM0
SRGLRRRGQPRVVVI	SMOX	16	Q9NWM0
GRPSRREPVRDVGRR	YTHDC1	521	Q96MU7
RICGRRKRPGGPEAR	ZBTB24	281	O43167
QRRPGGDRQRPEVRL	VWA8	31	A3KMH1
CRRQRRGGPVAPRAR	ZFTA	221	C9JLR9
GVCRERLRPEREPRL	TRIM28	66	Q13263