Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of platelet formation	MPL PRKDC	1.41e-05	2	78	2	GO:1905221
GeneOntologyBiologicalProcess	regulation of platelet formation	MPL PRKDC	4.23e-05	3	78	2	GO:1905219
Domain	Aur	AURKC AURKB	5.42e-05	3	80	2	IPR030616
Domain	Lipase_GDXG_put_SER_AS	AADACL2 NCEH1	1.08e-04	4	80	2	IPR033140
Domain	Arylacetamide_deacetylase	AADACL2 NCEH1	1.08e-04	4	80	2	IPR017157
Domain	Lipase_GDXG_HIS_AS	AADACL2 NCEH1	1.08e-04	4	80	2	IPR002168
Domain	LIPASE_GDXG_SER	AADACL2 NCEH1	2.69e-04	6	80	2	PS01174
Domain	LIPASE_GDXG_HIS	AADACL2 NCEH1	2.69e-04	6	80	2	PS01173
Domain	AB_hydrolase_3	AADACL2 NCEH1	3.75e-04	7	80	2	IPR013094
Domain	Abhydrolase_3	AADACL2 NCEH1	3.75e-04	7	80	2	PF07859
Domain	-	KDM5B ARID3A	1.83e-03	15	80	2	1.10.150.60
Domain	BRIGHT	KDM5B ARID3A	1.83e-03	15	80	2	SM00501
Domain	ARID_dom	KDM5B ARID3A	1.83e-03	15	80	2	IPR001606
Domain	ARID	KDM5B ARID3A	1.83e-03	15	80	2	PS51011
Domain	ARID	KDM5B ARID3A	1.83e-03	15	80	2	PF01388
Domain	TPR-contain_dom	FBXO9 TMTC2 PRKDC ZFC3H1	3.94e-03	150	80	4	IPR013026
Domain	PHD	KDM5B PHF10 PHF13	4.09e-03	75	80	3	PF00628
Domain	Znf_PHD-finger	KDM5B PHF10 PHF13	4.74e-03	79	80	3	IPR019787
Domain	TPR_REGION	FBXO9 TMTC2 PRKDC ZFC3H1	5.52e-03	165	80	4	PS50293
Domain	TPR	FBXO9 TMTC2 PRKDC ZFC3H1	5.52e-03	165	80	4	PS50005
Domain	Rho_GTPase_activation_prot	RASA2 ARHGAP30 CHN1	6.39e-03	88	80	3	IPR008936
Domain	PHD	KDM5B PHF10 PHF13	6.60e-03	89	80	3	SM00249
Domain	Znf_PHD	KDM5B PHF10 PHF13	7.01e-03	91	80	3	IPR001965
Domain	ZF_PHD_2	KDM5B PHF10 PHF13	7.89e-03	95	80	3	PS50016
Domain	ZF_PHD_1	KDM5B PHF10 PHF13	8.12e-03	96	80	3	PS01359
Pubmed	Hypoxia Stimulates SUMOylation-Dependent Stabilization of KDM5B.	PIAS4 KDM5B	5.23e-06	2	80	2	34977006
Pubmed	Purging human ovarian cortex of contaminating leukaemic cells by targeting the mitotic catastrophe signalling pathway.	AURKC AURKB	5.23e-06	2	80	2	33725274
Pubmed	Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells.	AURKC AURKB	5.23e-06	2	80	2	15499654
Pubmed	Overexpression of Aurora-C interferes with the spindle checkpoint by promoting the degradation of Aurora-B.	AURKC AURKB	5.23e-06	2	80	2	24603334
Pubmed	Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy.	AURKC AURKB	5.23e-06	2	80	2	28369513
Pubmed	Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes.	AURKC AURKB	5.23e-06	2	80	2	24586209
Pubmed	Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.	AURKC AURKB	5.23e-06	2	80	2	33172986
Pubmed	Maternally recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte maturation and early development.	AURKC AURKB	5.23e-06	2	80	2	22778418
Pubmed	Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme.	AURKC AURKB	5.23e-06	2	80	2	34465813
Pubmed	Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis.	AURKC AURKB	5.23e-06	2	80	2	17192404
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ATG5 PPP4R1 KDM5B LMO7 EIF4A3 LRSAM1 NARS1 PSMD5 PCMTD2 PRKDC ZFC3H1 KANK2 MED13	7.11e-06	1285	80	13	35914814
Pubmed	The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes.	AURKC AURKB	1.57e-05	3	80	2	21123620
Pubmed	Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis.	AURKC AURKB	1.57e-05	3	80	2	16386730
Pubmed	Modulation of epigenetic factors during the early stages of HIV-1 infection in CD4+ T cells in vitro.	AURKC AURKB	1.57e-05	3	80	2	30077875
Pubmed	Aurora kinase B inhibits aurora kinase A to control maternal mRNA translation in mouse oocytes.	AURKC AURKB	1.57e-05	3	80	2	34636397
Pubmed	Deregulation of Aurora kinase gene expression in human testicular germ cell tumours.	AURKC AURKB	1.57e-05	3	80	2	20629650
Pubmed	Differential Selective Pressures Experienced by the Aurora Kinase Gene Family.	AURKC AURKB	1.57e-05	3	80	2	29283376
Pubmed	SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo.	AURKC AURKB	1.57e-05	3	80	2	19649632
Pubmed	SAR156497, an exquisitely selective inhibitor of aurora kinases.	AURKC AURKB	1.57e-05	3	80	2	25369539
Pubmed	Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy.	AURKC AURKB	1.57e-05	3	80	2	15917996
Pubmed	Gene expression of Aurora kinases in prostate cancer and nodular hyperplasia tissues.	AURKC AURKB	1.57e-05	3	80	2	23075505
Pubmed	Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction.	AURKC AURKB	1.57e-05	3	80	2	32452402
Pubmed	Phosphorylation of the cryptochrome 1 C-terminal tail regulates circadian period length.	PRKDC CRY1	1.57e-05	3	80	2	24158435
Pubmed	Specialize and Divide (Twice): Functions of Three Aurora Kinase Homologs in Mammalian Oocyte Meiotic Maturation.	AURKC AURKB	1.57e-05	3	80	2	28359584
Pubmed	Genetic Interactions between the Aurora Kinases Reveal New Requirements for AURKB and AURKC during Oocyte Meiosis.	AURKC AURKB	1.57e-05	3	80	2	30415701
Pubmed	The aurora kinases in cell cycle and leukemia.	AURKC AURKB	1.57e-05	3	80	2	24632603
Pubmed	Bile acid receptor TGR5, NADPH Oxidase NOX5-S and CREB Mediate Bile Acid-Induced DNA Damage In Barrett's Esophageal Adenocarcinoma Cells.	GPBAR1 NOX5	1.57e-05	3	80	2	27511066
Pubmed	Aurora A, centrosome structure, and the centrosome cycle.	AURKC AURKB	1.57e-05	3	80	2	19774610
Pubmed	Regulation of spindle and chromatin dynamics during early and late stages of oocyte maturation by aurora kinases.	AURKC AURKB	1.57e-05	3	80	2	18353803
Pubmed	Characterization and risk association of polymorphisms in Aurora kinases A, B and C with genetic susceptibility to gastric cancer development.	AURKC AURKB	1.57e-05	3	80	2	31521144
Pubmed	Caenorhabditis elegans Aurora A kinase AIR-1 is required for postembryonic cell divisions and germline development.	AURKC AURKB	1.57e-05	3	80	2	12434334
Pubmed	Thrombopoietin-increased DNA-PK-dependent DNA repair limits hematopoietic stem and progenitor cell mutagenesis in response to DNA damage.	MPL PRKDC	1.57e-05	3	80	2	23246483
Pubmed	Inefficient double-strand break repair in murine rod photoreceptors with inverted heterochromatin organization.	PRKDC PHF13	1.57e-05	3	80	2	24794298
Pubmed	Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex.	AURKC AURKB	3.13e-05	4	80	2	27332895
Pubmed	Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.	AURKC AURKB	3.13e-05	4	80	2	15316025
Pubmed	TIP60 K430 SUMOylation attenuates its interaction with DNA-PKcs in S-phase cells: Facilitating homologous recombination and emerging target for cancer therapy.	PIAS4 PRKDC	3.13e-05	4	80	2	32832608
Pubmed	ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy.	ATG5 AURKB	3.13e-05	4	80	2	23945651
Pubmed	SUMOylation modulates the function of Aurora-B kinase.	AURKC AURKB	3.13e-05	4	80	2	20663916
Pubmed	Endothelial Reprogramming Stimulated by Oncostatin M Promotes Inflammation and Tumorigenesis in VHL-Deficient Kidney Tissue.	VHLL PRKDC	5.20e-05	5	80	2	34301760
Pubmed	Dynamic relocalization of the chromosomal passenger complex proteins inner centromere protein (INCENP) and aurora-B kinase during male mouse meiosis.	AURKC AURKB	5.20e-05	5	80	2	12584241
Pubmed	Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation.	VHLL IPMK	5.20e-05	5	80	2	29279301
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	ATG5 PPP4R1 FBXO9 TBC1D2B GIGYF2 LRRC58 KANK2 ADD1 AURKB CRY1	1.33e-04	1038	80	10	26673895
Pubmed	Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia.	SOCS3 VHLL	1.45e-04	8	80	2	21685897
Pubmed	Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction.	PRKDC AURKB	1.45e-04	8	80	2	29946151
Pubmed	Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model.	AURKC AURKB	1.45e-04	8	80	2	14602875
Pubmed	Peroxisome-Deficiency and HIF-2α Signaling Are Negative Regulators of Ketohexokinase Expression.	ATG5 VHLL	1.86e-04	9	80	2	32733884
Pubmed	Gene-load score of the renin-angiotensin-aldosterone system is associated with coronary heart disease in familial hypercholesterolaemia.	ADRA1A ADD1	1.86e-04	9	80	2	18413308
Pubmed	Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development.	AURKC AURKB	1.86e-04	9	80	2	21613325
Pubmed	Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA.	ATG5 PRKDC	2.84e-04	11	80	2	28973896
Pubmed	The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules.	LMO7 PRKDC POF1B	4.62e-04	65	80	3	32521226
Pubmed	SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.	FBXO9 CRY1	4.67e-04	14	80	2	17463251
Pubmed	FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.	MED13 AURKB	5.38e-04	15	80	2	31285543
Pubmed	The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.	ADRA1A ADD1	6.14e-04	16	80	2	15824464
Pubmed	VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.	SOCS3 VHLL	7.81e-04	18	80	2	15601820
Pubmed	The contribution of de novo coding mutations to autism spectrum disorder.	KDM5B GIGYF2	7.81e-04	18	80	2	25363768
Pubmed	Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts.	ATG5 ATP6V0D2	9.66e-04	20	80	2	22982048
Pubmed	RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons.	TRIL KANK2	1.17e-03	22	80	2	33903225
Pubmed	A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.	LMO7 PHF10	1.17e-03	22	80	2	21980299
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	ERCC3 LMO7 GIGYF2 ZFC3H1 PHF10 ADD1 AURKB	1.40e-03	724	80	7	36232890
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	TRIL GIGYF2 ANKLE2	1.71e-03	102	80	3	9734811
Pubmed	Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.	TBC1D10A TBC1D2B	1.77e-03	27	80	2	22354992
Pubmed	Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease.	NARS1 PRKDC	1.77e-03	27	80	2	36266428
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	TBC1D10A LMO7 GIGYF2 KANK2 POF1B ADD1	1.95e-03	565	80	6	25468996
Pubmed	AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.	EIF4A3 PRKDC	2.04e-03	29	80	2	20371770
Cytoband	12q24.33	NOC4L RIMBP2 ANKLE2	8.33e-05	48	80	3	12q24.33
Disease	Constipation	GPBAR1 MED13	1.47e-04	7	79	2	C0009806
Disease	level of C-X-C motif chemokine 2 in blood serum	KIRREL1 NAXE	4.59e-04	12	79	2	OBA_2041207
Disease	level of C-X-C motif chemokine 3 in blood serum	KIRREL1 NAXE	7.27e-04	15	79	2	OBA_2041208
Disease	non-alcoholic steatohepatitis (biomarker_via_orthology)	GPBAR1 CYP7A1	9.38e-04	17	79	2	DOID:0080547 (biomarker_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	KDM5B ADRA1A GSTO2 PHF10	1.89e-03	195	79	4	DOID:1574 (implicated_via_orthology)
Disease	brain cancer (implicated_via_orthology)	AURKC AURKB	2.21e-03	26	79	2	DOID:1319 (implicated_via_orthology)
Disease	colorectal cancer, breast carcinoma	AADACL2 RIMBP2	2.21e-03	26	79	2	EFO_0000305, MONDO_0005575
Disease	lobe attachment	ATG5 TRIL PRKDC NPVF	2.34e-03	207	79	4	EFO_0007667

Protein segments in the cluster

Peptide	Gene	Start	Entry
YRKDYVYTEPILGGL	AADACL2	291	Q6P093
YRAGATASKEPPLYY	ANKLE2	186	Q86XL3
VYLILEYAPRGELYK	AURKC	116	Q9UQB9
FEGLLRPYIEYPSYN	BTNL8	436	Q6UX41
YSNRLYTYEPRDLPL	AGR3	136	Q8TD06
SIDRYIGVSYPLRYP	ADRA1A	121	P35348
YPKDLLVYAWYRGPA	CEACAM16	341	Q2WEN9
RPPYYLGRDYLETLM	DUS3L	601	Q96G46
EAEPYYLLLPRVSYL	ATG5	31	Q9H1Y0
TEDYVLPSEYYGPLK	RASA2	316	Q15283
TSTRGDKYLYEPVYP	RIC1	96	Q4ADV7
FIVRYGYIYPLQDPK	RGS9	76	O75916
FDSYLKTLPPYYLLT	INTS6L	416	Q5JSJ4
YRPGDYLYLNIPTIA	NOX5	471	Q96PH1
KDNPYITDGYRAYLP	PAQR3	41	Q6TCH7
EEPLYPSYKRQLRIY	ANO10	301	Q9NW15
LKLFGYEPTIYYPKR	NAXE	131	Q8NCW5
PAIALDRYYSVLYPL	GPR176	136	Q14439
YFRATYPLLKADPSL	MGAT1	221	P26572
KESGLEYYPPSQYLL	LRSAM1	206	Q6UWE0
FPAPYLYLEVYGLLL	GPBAR1	161	Q8TDU6
GFKEQIYDVYRYLPP	EIF4A3	196	P38919
PLPDPLKYYLLYYRE	PCMTD2	346	Q9NV79
LVALAAYYVYIPLPG	NCEH1	11	Q6PIU2
EYLDDAYPGRKLFPY	GSTO2	91	Q9H4Y5
AYPGRKLFPYDPYER	GSTO2	96	Q9H4Y5
YEGPLRLLRAKYAYS	HEXD	51	Q8WVB3
IYQYRRPVDSYDIPK	LMO7	1391	Q8WWI1
PPYKYKLRYRYTLDD	KDM5B	726	Q9UGL1
PAELTYYTLYNGKPL	KIAA1549L	1126	Q6ZVL6
PILGLLYDDYEYIPP	POF1B	556	Q8WVV4
GVLLELRKYLPKYYG	IPMK	101	Q8NFU5
SYTPYDLPGNLLRYL	LRRC58	276	Q96CX6
YKRYSPDELRYLPLN	PHF10	266	Q8WUB8
PALPKYKLADYRYGR	GIGYF2	31	Q6Y7W6
EKPLDYKYRYFRRVP	FBXO9	361	Q9UK97
RYLPVLRGFPAKYIY	CRY1	431	Q16526
PYSVETPYGYRLDLD	KANK2	31	Q63ZY3
LERTPYEAYDPIGKY	KIRREL1	716	Q96J84
YPDPLTFKYDRYLDE	CYP7A1	401	P22680
YAIRLNKPYIYGPTS	ERCC3	571	P19447
YFRDLPIPLITYDAY	CHN1	346	P15882
PSYILRTPEGIYRYG	RNF103	286	O00237
LEYPDFYRKLYGLLD	NOC4L	321	Q9BVI4
LSYLLSGYTPYTKPD	OSGIN1	31	Q9UJX0
LKYSEAEYAPPIYIA	NUP210L	191	Q5VU65
LPDPLLTYRLYDKFA	ARHGAP30	101	Q7Z6I6
ELPLTAGKYLYVYGD	RIMBP2	191	O15034
SRYPRYLYGLPDDIS	TMEM178B	231	H3BS89
IDYYLPKLLSYSPES	THADA	546	Q6YHU6
SLGKLLPYEPENYPY	SPAG8	446	Q99932
GNYLEADVRLPKPYY	TEX14	471	Q8IWB6
ELYSPRDVYDYLRPI	PPP4R1	771	Q8TF05
LAGYKREGIDPTPYY	NARS1	486	O43776
YYASTPGPLYKLLQE	TEDDM1	241	Q5T9Z0
PKELDPIVTRRYYYS	LAMA1	246	P25391
PGAYQGIIYYLKPDL	SLC6A12	261	P48065
AGPPRYLGDRYKFYL	SLAMF1	86	Q13291
LNYYGKLLPYLTLLP	VHLL	71	Q6RSH7
YFYRGIYPPLLSKTL	SLC25A53	76	Q5H9E4
LPIPTFLLGYDYDYL	MED13	1331	Q9UHV7
TGYPYRYPALREKSK	ADD1	391	P35611
YLYPYECEKRGLSNP	ARID3A	321	Q99856
RKLLPVLDPSGDYYY	CNGA4	21	Q8IV77
YLILEYAPRGELYKE	AURKB	151	Q96GD4
LAYAGYIPYPKEELP	PHF13	36	Q86YI8
GVDKGLFPLYYLYLE	TULP2	296	O00295
APPLYTLIDVLKYSY	ZSWIM9	61	Q86XI8
YDKYSEPRGYPKGER	NPVF	41	Q9HCQ7
YLLSYYPLGKELSGK	TNN	291	Q9UQP3
KYYDLAARLRPNYPA	TMTC2	766	Q8N394
RHPPALRGKYLDYLD	TRIL	391	Q7L0X0
PRRAYYIYSGGEKIP	SOCS3	161	O14543
GTYQLLYAYPREKPR	MPL	61	P40238
LAGPNIDYPVLYGKY	PIAS4	101	Q8N2W9
QPYYKDILPCLDGYL	PRKDC	786	P78527
PNYLRLRTYLSEGPY	PSMD5	476	Q16401
LRTYLSEGPYYVKPV	PSMD5	481	Q16401
RVLKAYTLYRPEEGY	TBC1D10A	181	Q9BXI6
YLYYFKSPQDALPLG	TBC1D2B	66	Q9UPU7
YRFSPYYRTKEKLPL	ZFC3H1	1156	O60293
YPTFGKLYPEGLRLL	ATP6V0D2	241	Q8N8Y2