Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	intraciliary transport particle B	RABL2B RABL2A	4.98e-04	21	33	2	GO:0030992
GeneOntologyCellularComponent	phagophore assembly site membrane	ATG9A ATG2B	5.47e-04	22	33	2	GO:0034045
GeneOntologyCellularComponent	intraciliary transport particle	RABL2B RABL2A	8.90e-04	28	33	2	GO:0030990
GeneOntologyCellularComponent	pericentriolar material	RABL2B RABL2A	8.90e-04	28	33	2	GO:0000242
MousePheno	abnormal social/conspecific interaction behavior	GRIN1 PATE4 ARSK SRGAP3 CYP19A1 DLGAP4 KLHL17	1.13e-05	421	27	7	MP:0002557
MousePheno	abnormal response to novelty	GRIN1 ARIH1 GRM8 SRGAP3 CYP19A1 DLGAP4 ATG2B KLHL17	8.29e-05	787	27	8	MP:0003107
Domain	FCH	SRGAP3 SRGAP1	6.03e-04	22	31	2	PF00611
Domain	FCH	SRGAP3 SRGAP1	6.03e-04	22	31	2	SM00055
Domain	FCH_dom	SRGAP3 SRGAP1	6.60e-04	23	31	2	IPR001060
Domain	F_BAR	SRGAP3 SRGAP1	7.81e-04	25	31	2	IPR031160
Domain	F_BAR	SRGAP3 SRGAP1	7.81e-04	25	31	2	PS51741
Domain	ANF_receptor	GRIN1 GRM8	1.71e-03	37	31	2	PF01094
Domain	ANF_lig-bd_rcpt	GRIN1 GRM8	1.71e-03	37	31	2	IPR001828
Domain	Peripla_BP_I	GRIN1 GRM8	1.90e-03	39	31	2	IPR028082
Domain	RhoGAP	SRGAP3 SRGAP1	4.74e-03	62	31	2	SM00324
Domain	RhoGAP	SRGAP3 SRGAP1	4.89e-03	63	31	2	PF00620
Domain	RHOGAP	SRGAP3 SRGAP1	5.04e-03	64	31	2	PS50238
Domain	RhoGAP_dom	SRGAP3 SRGAP1	5.04e-03	64	31	2	IPR000198
Domain	-	SRGAP3 SRGAP1	5.04e-03	64	31	2	1.10.555.10
Domain	RAB	RABL2B RABL2A	6.51e-03	73	31	2	PS51419
Domain	Rho_GTPase_activation_prot	SRGAP3 SRGAP1	9.34e-03	88	31	2	IPR008936
Domain	P-loop_NTPase	RECQL RABL2B RABL2A KIF26A SULT1C3	1.21e-02	848	31	5	IPR027417
Pathway	REACTOME_INACTIVATION_OF_CDC42_AND_RAC1	SRGAP3 SRGAP1	8.40e-05	8	25	2	M27349
Pubmed	Two novel human RAB genes with near identical sequence each map to a telomere-associated region: the subtelomeric region of 22q13.3 and the ancestral telomere band 2q13.	RABL2B RABL2A	8.73e-07	2	33	2	10444334
Pubmed	Variants in RABL2A causing male infertility and ciliopathy.	RABL2B RABL2A	8.73e-07	2	33	2	33075816
Pubmed	RABL2 Is Required for Hepatic Fatty Acid Homeostasis and Its Dysfunction Leads to Steatosis and a Diabetes-Like State.	RABL2B RABL2A	8.73e-07	2	33	2	27732084
Pubmed	RABL2 positively controls localization of GPCRs in mammalian primary cilia.	RABL2B RABL2A	8.73e-07	2	33	2	30578315
Pubmed	Analysis of relative gene dosage and expression differences of the paralogs RABL2A and RABL2B by Pyrosequencing.	RABL2B RABL2A	8.73e-07	2	33	2	20138207
Pubmed	Slit-Robo GTPase-activating proteins are differentially expressed in murine dorsal root ganglia: modulation by peripheral nerve injury.	SRGAP3 SRGAP1	8.73e-07	2	33	2	22271578
Pubmed	Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system.	SRGAP3 SRGAP1	2.62e-06	3	33	2	19137586
Pubmed	Aberrant methylation of ATG2B, ATG4D, ATG9A and ATG9B CpG island promoter is associated with decreased mRNA expression in sporadic breast carcinoma.	ATG9A ATG2B	5.23e-06	4	33	2	27265029
Pubmed	Genome-wide ENU mutagenesis to reveal immune regulators.	RABL2B RABL2A	5.23e-06	4	33	2	11567631
Pubmed	Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune ciliary signaling.	RABL2B RABL2A	8.72e-06	5	33	2	33241915
Pubmed	Macrophage autophagy in immunity to Cryptococcus neoformans and Candida albicans.	ATG9A ATG2B	8.72e-06	5	33	2	22710871
Pubmed	SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance.	SRGAP3 SRGAP1	1.31e-05	6	33	2	33514561
Pubmed	FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains.	SRGAP3 SRGAP1	1.31e-05	6	33	2	12736724
Pubmed	Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.	SRGAP3 SRGAP1	1.31e-05	6	33	2	11672528
Pubmed	Evidence for a role of srGAP3 in the positioning of commissural axons within the ventrolateral funiculus of the mouse spinal cord.	SRGAP3 SRGAP1	1.83e-05	7	33	2	21655271
Pubmed	Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner.	RECQL TERF1	1.83e-05	7	33	2	24895130
Pubmed	The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.	RABL2B RABL2A	5.73e-05	12	33	2	28625565
Pubmed	RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.	RABL2B RABL2A DLGAP4	9.23e-05	92	33	3	23055941
Pubmed	Loss of miR-17~92 results in dysregulation of Cftr in nephron progenitors.	RABL2B RABL2A	1.18e-04	17	33	2	30838872
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIN1 GRM8	2.38e-04	24	33	2	35746896
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	HAUS6 ZNF280D ZBTB1 ATG2B	6.39e-04	418	33	4	34709266
Pubmed	Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.	GRIN1 GRM8	8.43e-04	45	33	2	25979088
Pubmed	Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice.	RABL2B RABL2A	9.19e-04	47	33	2	15172686
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	RABL2B RABL2A TUBGCP2 SRGAP1	9.27e-04	462	33	4	31138677
Interaction	KLHL7 interactions	ARIH1 SRGAP1 CYP19A1 KLHL17	5.28e-06	73	32	4	int:KLHL7
Interaction	DOCK1 interactions	GRIN1 ATG9A SRGAP1 KLHL17	8.39e-06	82	32	4	int:DOCK1
GeneFamily	RAB like GTPases	RABL2B RABL2A	1.68e-05	5	24	2	394
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	SRGAP3 SRGAP1	4.20e-04	23	24	2	1288
GeneFamily	Autophagy related	ATG9A ATG2B	8.70e-04	33	24	2	1022
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	SRGAP3 SRGAP1	1.99e-03	50	24	2	721
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB1 KLHL17	1.35e-02	134	24	2	861
CoexpressionAtlas	FacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#2	HAUS6 NOL10 ZNF280D ACAP2 ARSK ZBTB1 DLGAP4	2.11e-05	564	33	7	Facebase_RNAseq_e9.5_Mandibular Arch_2500_K2
Disease	placental insufficiency (biomarker_via_orthology)	GRIN1 CYP19A1	3.18e-05	8	32	2	DOID:3891 (biomarker_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	GRIN1 ZNF280D DLGAP4	5.96e-04	152	32	3	DOID:0060041 (implicated_via_orthology)
Disease	schizophrenia (implicated_via_orthology)	GRIN1 SRGAP3	2.48e-03	68	32	2	DOID:5419 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SKAYVNHMMSFHSNR	ZNF280D	656	Q6N043
HRQFYKMSMYEASAH	ARSK	321	Q6UWY0
YFMKLDAGVNMYHHF	EOGT	236	Q5NDL2
DIFMDTSYAIAMHFH	CRAT	536	P43155
SMLSFMYAHLAFFHQ	ACAP2	191	Q15057
YFMHAYNTISGHMLK	DLGAP4	241	Q9Y2H0
MMASHMYTSYNKHIS	ATG2B	706	Q96BY7
YFRGDKHMYSTHMCK	PATE4	56	P0C8F1
ERFQSMHASYYHKAH	RABL2A	81	Q9UBK7
ERFQSMHASYYHKAH	RABL2B	81	Q9UNT1
YMNHMQSLRFEHKLY	ARIH1	421	Q9Y4X5
MLHFHYYDTSNKIME	IDO2	1	Q6ZQW0
SSHMLFTLHVYQYRM	KIF26A	601	Q9ULI4
TRYQMLFRHMFYCKH	TUBGCP2	636	Q9BSJ2
RAYMHGFFMDIRLYH	NOL10	396	Q9BSC4
IDAVYSMAYALHNMH	GRM8	406	O00222
FFYALMHSVMTAHLS	OR12D3	151	Q9UGF7
SKRHYHDAFVAMSRM	KLHL17	71	Q6TDP4
SSMFHIMKHNHYSSR	CYP19A1	101	P11511
YASTEMSLHALYMHQ	ATG9A	701	Q7Z3C6
HLMYHFARFVAMKYI	HAUS6	126	Q7Z4H7
VSYYHFHRMASFMPD	SULT1C3	146	Q6IMI6
LYTVMKTYHMYHAES	SRGAP1	161	Q7Z6B7
SMKQASYMYRHSHDG	SCN4A	1746	P35499
HNAQAMFNLAYMYEH	SEL1L2	586	Q5TEA6
VIHHSMSKSMENYYQ	RECQL	386	P46063
YTVMKTYHMYHAESI	SRGAP3	161	O43295
SFFQHFSYNHMMEKI	TERF1	226	P54274
YDHMSFHYTVVLMFS	TMEM262	46	E9PQX1
SSYFRMFFMNHQHST	ZBTB1	46	Q9Y2K1
MVAKHLVMFYYFAQH	ZNF117	6	Q03924
EYTYSKHGMHFTHNM	ZNF891	266	A8MT65
TMYRHMEKHNYESAA	GRIN1	701	Q05586