Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	threonine-tRNA ligase activity	TARS3 TARS1	3.73e-05	3	71	2	GO:0004829
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	RALGAPA1 EPS8L2 RASA4 ITSN2 LRRK2 RASA4B RPGR DENND1A RGS3	7.52e-05	507	71	9	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	RALGAPA1 EPS8L2 RASA4 ITSN2 LRRK2 RASA4B RPGR DENND1A RGS3	7.52e-05	507	71	9	GO:0030695
GeneOntologyMolecularFunction	actin filament binding	EPS8L2 CORO2B MYH13 TLN1 NEB MPRIP	1.56e-04	227	71	6	GO:0051015
GeneOntologyMolecularFunction	enzyme regulator activity	RALGAPA1 AHCYL1 EPS8L2 PLAA CCNB3 RASA4 PPP1R12B ITSN2 LRRK2 RASA4B RPGR IL2 DENND1A RGS3	4.06e-04	1418	71	14	GO:0030234
GeneOntologyBiologicalProcess	threonyl-tRNA aminoacylation	TARS3 TARS1	3.60e-05	3	72	2	GO:0006435
GeneOntologyBiologicalProcess	synaptic vesicle recycling	PLAA ITSN2 LRRK2 AP3M2 DENND1A	4.33e-05	111	72	5	GO:0036465
Domain	-	RASA4 RASA4B	4.39e-05	3	72	2	4.10.1130.10
Domain	ThrRS_core	TARS3 TARS1	4.39e-05	3	72	2	IPR033728
Domain	Thr-tRNA-ligase_IIa	TARS3 TARS1	4.39e-05	3	72	2	IPR002320
Domain	TGS	TARS3 TARS1	2.18e-04	6	72	2	IPR004095
Domain	TGS	TARS3 TARS1	2.18e-04	6	72	2	PF02824
Domain	TGS-like	TARS3 TARS1	3.04e-04	7	72	2	IPR012676
Domain	tRNA_SAD	TARS3 TARS1	3.04e-04	7	72	2	SM00863
Domain	tRNA_SAD	TARS3 TARS1	3.04e-04	7	72	2	IPR012947
Domain	tRNA_SAD	TARS3 TARS1	3.04e-04	7	72	2	PF07973
Domain	Thr/Ala-tRNA-synth_IIc_edit	TARS3 TARS1	4.04e-04	8	72	2	IPR018163
Domain	BTK	RASA4 RASA4B	5.18e-04	9	72	2	SM00107
Domain	Znf_Btk_motif	RASA4 RASA4B	5.18e-04	9	72	2	IPR001562
Domain	BTK	RASA4 RASA4B	5.18e-04	9	72	2	PF00779
Domain	ZF_BTK	RASA4 RASA4B	5.18e-04	9	72	2	PS51113
Domain	HGTP_anticodon	TARS3 TARS1	5.18e-04	9	72	2	PF03129
Domain	EF-hand_4	ITSN2 EHD4	6.46e-04	10	72	2	PF12763
Domain	-	EPS8L2 RASA4 TLN1 ITSN2 RASA4B RGS3 MPRIP	7.64e-04	391	72	7	2.30.29.30
Domain	aa-tRNA-synt_IIb	TARS3 TARS1	7.88e-04	11	72	2	IPR002314
Domain	tRNA-synt_2b	TARS3 TARS1	7.88e-04	11	72	2	PF00587
Domain	-	TARS3 TARS1	7.88e-04	11	72	2	3.40.50.800
Domain	EH	ITSN2 EHD4	7.88e-04	11	72	2	PS50031
Domain	EH	ITSN2 EHD4	7.88e-04	11	72	2	SM00027
Domain	EH_dom	ITSN2 EHD4	7.88e-04	11	72	2	IPR000261
Domain	PH_dom-like	EPS8L2 RASA4 TLN1 ITSN2 RASA4B RGS3 MPRIP	1.26e-03	426	72	7	IPR011993
Domain	RasGAP	RASA4 RASA4B	1.29e-03	14	72	2	SM00323
Domain	Beta-grasp_dom	TARS3 TARS1	1.29e-03	14	72	2	IPR012675
Domain	-	TARS3 TARS1	1.29e-03	14	72	2	3.10.20.30
Domain	Anticodon-bd	TARS3 TARS1	1.29e-03	14	72	2	IPR004154
Domain	RasGAP_CS	RASA4 RASA4B	1.29e-03	14	72	2	IPR023152
Domain	RasGAP	RASA4 RASA4B	1.49e-03	15	72	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA4 RASA4B	1.49e-03	15	72	2	PS00509
Domain	RAS_GTPASE_ACTIV_2	RASA4 RASA4B	1.49e-03	15	72	2	PS50018
Domain	C2	RASA4 ITSN2 RASA4B RGS3	1.64e-03	131	72	4	PF00168
Domain	-	RASA4 RASA4B	1.70e-03	16	72	2	1.10.506.10
Domain	C2	RASA4 ITSN2 RASA4B RGS3	1.94e-03	137	72	4	SM00239
Domain	aa-tRNA-synth_II	TARS3 TARS1	2.15e-03	18	72	2	IPR006195
Domain	RasGAP_dom	RASA4 RASA4B	2.15e-03	18	72	2	IPR001936
Domain	AA_TRNA_LIGASE_II	TARS3 TARS1	2.15e-03	18	72	2	PS50862
Domain	C2	RASA4 ITSN2 RASA4B RGS3	2.21e-03	142	72	4	PS50004
Domain	-	RASA4 ITSN2 RASA4B RGS3	2.57e-03	148	72	4	2.60.40.150
Domain	SH3_9	ITSN2 SNX18 NEB	3.40e-03	78	72	3	PF14604
Domain	C2_dom	RASA4 ITSN2 RASA4B RGS3	3.71e-03	164	72	4	IPR000008
Domain	SH3_1	EPS8L2 ITSN2 SNX18 NEB	3.71e-03	164	72	4	PF00018
Pathway	BIOCARTA_NTHI_PATHWAY	MYD88 RELA IL1B	1.18e-04	22	62	3	MM1443
Pathway	BIOCARTA_NTHI_PATHWAY	MYD88 RELA IL1B	1.35e-04	23	62	3	M2821
Pathway	WP_FOLATE_METABOLISM	MTHFR RELA IL1B IL2	2.37e-04	69	62	4	M39617
Pathway	REACTOME_CLEC7A_INFLAMMASOME_PATHWAY	RELA IL1B	2.82e-04	6	62	2	M27542
Pathway	BIOCARTA_IL1R_PATHWAY	MYD88 RELA IL1B	3.34e-04	31	62	3	M12095
Pathway	REACTOME_DEX_H_BOX_HELICASES_ACTIVATE_TYPE_I_IFN_AND_INFLAMMATORY_CYTOKINES_PRODUCTION	MYD88 RELA	3.94e-04	7	62	2	MM14930
Pathway	WP_ACTIVATION_OF_NLRP3_INFLAMMASOME_BY_SARSCOV2	RELA IL1B	3.94e-04	7	62	2	M39874
Pathway	REACTOME_DEX_H_BOX_HELICASES_ACTIVATE_TYPE_I_IFN_AND_INFLAMMATORY_CYTOKINES_PRODUCTION	MYD88 RELA	3.94e-04	7	62	2	M27227
Pathway	WP_SIGNAL_TRANSDUCTION_THROUGH_IL1R	MYD88 RELA IL1B	4.02e-04	33	62	3	M39803
Pathway	PID_IL1_PATHWAY	MYD88 RELA IL1B	4.40e-04	34	62	3	M110
Pathway	WP_PHOTODYNAMIC_THERAPYINDUCED_NFKB_SURVIVAL_SIGNALING	RELA IL1B IL2	4.80e-04	35	62	3	M39529
Pathway	PID_IL23_PATHWAY	RELA IL1B IL2	5.66e-04	37	62	3	M196
Pathway	WP_ALLOGRAFT_REJECTION	LRRK2 C9 IL1B IL2	6.26e-04	89	62	4	M39398
Pathway	WP_SMITHMAGENIS_AND_POTOCKILUPSKI_SYNDROME_COPY_NUMBER_VARIATION	MYD88 IFT172 RELA IL1B MPRIP	6.61e-04	159	62	5	M48090
Pathway	WP_IL1_SIGNALING_PATHWAY	MYD88 RELA IL1B	6.61e-04	39	62	3	MM15996
Pathway	REACTOME_INTERLEUKIN_1_PROCESSING	RELA IL1B	6.72e-04	9	62	2	M27383
Pathway	REACTOME_INTERLEUKIN_1_PROCESSING	RELA IL1B	6.72e-04	9	62	2	MM15129
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	EPS8L2 MYH13 PTPRO ANXA6 TLN1 ITSN2 LRRK2 SNX18 PKHD1 SLC4A4 C9 NEB EHD4	1.78e-07	1016	73	13	19056867
Pubmed	Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF.	MYD88 RELA IL1B	7.38e-07	9	73	3	34529751
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SPCS3 AHCYL1 SMARCA5 MYH13 GAR1 PPP1R12B ITSN2 PKHD1 SMARCC2 ATG4C PSMD8 EBNA1BP2 NEB EHD4	1.56e-06	1442	73	14	35575683
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	AHCYL1 SMARCA5 PLAA POLA1 TLN1 EXOC3 SMARCC2 EBNA1BP2 USP16 SNRPD2 TARS1 MPRIP EHD4	4.33e-06	1353	73	13	29467282
Pubmed	Prolonged neuroinflammation after lipopolysaccharide exposure in aged rats.	RELA IL1B	4.35e-06	2	73	2	25170959
Pubmed	Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development.	TARS3 TARS1	4.35e-06	2	73	2	37059185
Pubmed	Synthesis and Spectroscopic Analysis of Piperine- and Piperlongumine-Inspired Natural Product Scaffolds and Their Molecular Docking with IL-1β and NF-κB Proteins.	RELA IL1B	4.35e-06	2	73	2	32575582
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4 RASA4B	4.35e-06	2	73	2	11448776
Pubmed	Listeria monocytogenes infection in macrophages induces vacuolar-dependent host miRNA response.	MYD88 RELA	4.35e-06	2	73	2	22114673
Pubmed	IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1).	AHCYL1 SLC4A4	4.35e-06	2	73	2	16769890
Pubmed	MyD88-dependent pro-interleukin-1β induction in dendritic cells exposed to food-grade synthetic amorphous silica.	MYD88 IL1B	4.35e-06	2	73	2	28645296
Pubmed	Repletion of zinc in zinc-deficient cells strongly up-regulates IL-1β-induced IL-2 production in T-cells.	IL1B IL2	4.35e-06	2	73	2	22983538
Pubmed	Relief of autoinhibition of the electrogenic Na-HCO(3) [corrected] cotransporter NBCe1-B: role of IRBIT vs.amino-terminal truncation.	AHCYL1 SLC4A4	4.35e-06	2	73	2	22012331
Pubmed	The Viral Tegument Protein pp65 Impairs Transcriptional Upregulation of IL-1β by Human Cytomegalovirus through Inhibition of NF-kB Activity.	RELA IL1B	4.35e-06	2	73	2	30332797
Pubmed	p65-Dependent production of interleukin-1β by osteolytic prostate cancer cells causes an induction of chemokine expression in osteoblasts.	RELA IL1B	4.35e-06	2	73	2	22108531
Pubmed	Low dose ionising radiation leads to a NF-κB dependent decreased secretion of active IL-1β by activated macrophages with a discontinuous dose-dependency.	RELA IL1B	4.35e-06	2	73	2	22545750
Pubmed	Cyclic Stretch Force Induces Periodontal Ligament Cells to Secrete Exosomes That Suppress IL-1β Production Through the Inhibition of the NF-κB Signaling Pathway in Macrophages.	RELA IL1B	4.35e-06	2	73	2	31281309
Pubmed	A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities.	TARS3 TARS1	4.35e-06	2	73	2	29579307
Pubmed	Nuclear Translocation of p65 is Controlled by Sec6 via the Degradation of IκBα.	EXOC3 RELA	4.35e-06	2	73	2	26247921
Pubmed	A polysaccharide extract from the medicinal plant Maidong inhibits the IKK-NF-κB pathway and IL-1β-induced islet inflammation and increases insulin secretion.	RELA IL1B	4.35e-06	2	73	2	32605924
Pubmed	Regulation of murine hepatic hydroxysteroid sulfotransferase expression in hyposulfatemic mice and in a cell model of 3'-phosphoadenosine-5'-phosphosulfate deficiency.	SLC13A1 SULT2A1	4.35e-06	2	73	2	23674610
Pubmed	A TIR domain protein from E. faecalis attenuates MyD88-mediated signaling and NF-κB activation.	MYD88 RELA	4.35e-06	2	73	2	25369374
Pubmed	Annexin A6 regulates interleukin-2-mediated T-cell proliferation.	ANXA6 IL2	4.35e-06	2	73	2	26853809
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4 RASA4B	4.35e-06	2	73	2	16041389
Pubmed	Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility.	CFAP47 CFAP65	4.35e-06	2	73	2	33472045
Pubmed	IL1beta+3953 exon 5 and IL-2 -330 promoter polymorphisms in patients with rheumatoid arthritis.	IL1B IL2	4.35e-06	2	73	2	15895884
Pubmed	Dexamethasone inhibits interleukin-1beta-induced corneal neovascularization: role of nuclear factor-kappaB-activated stromal cells in inflammatory angiogenesis.	RELA IL1B	4.35e-06	2	73	2	17690185
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	PLAA GAR1 PPP1R12B TLN1 ITSN2 SMC6 EXOC3 SMARCC2 SGO2 EBNA1BP2 SNRPD2 MPRIP	4.83e-06	1155	73	12	20360068
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	SMARCA5 GAR1 POLA1 ANXA6 TLN1 KIAA0586 SMC6 SGO2 PSMD8 EBNA1BP2 SNRPD2 TARS1 EHD4	7.58e-06	1425	73	13	30948266
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	RALGAPA1 AHCYL1 TARS3 CORO2B PPP1R12B TLN1 ITSN2 SMARCC2 ITGA2 SLC4A4 SNRPD2 TARS1 MPRIP	7.93e-06	1431	73	13	37142655
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	SMARCA5 MYH13 GAR1 TOPAZ1 EXOC3 AK9 NEB RYR3	9.80e-06	497	73	8	36774506
Pubmed	Candidate gene polymorphisms for ischemic stroke.	MTHFR ITGA2 IL1B F13B	1.03e-05	64	73	4	19729601
Pubmed	The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokines.	MYD88 IL1B	1.30e-05	3	73	2	25058342
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4 RASA4B	1.30e-05	3	73	2	25637021
Pubmed	Interleukin-1beta up-regulation of Smad7 via NF-kappaB activation in human chondrocytes.	RELA IL1B	1.30e-05	3	73	2	18163503
Pubmed	Cleavage of the NF-κB family protein p65/RelA by the chlamydial protease-like activity factor (CPAF) impairs proinflammatory signaling in cells infected with Chlamydiae.	RELA IL1B	1.30e-05	3	73	2	21041296
Pubmed	Rabies Virus Regulates Inflammatory Response in BV-2 Cells through Activation of Myd88 and NF-κB Signaling Pathways via TLR7.	MYD88 RELA	1.30e-05	3	73	2	39273091
Pubmed	Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling.	MYD88 IL1B	1.30e-05	3	73	2	33958388
Pubmed	Screening of posttranscriptional regulatory molecules of IκB-ζ.	MYD88 IL1B	1.30e-05	3	73	2	26711529
Pubmed	The association of IL-1beta, IL-2, and IL-6 gene polymorphisms with bone mineral density and osteoporosis in postmenopausal women.	IL1B IL2	1.30e-05	3	73	2	20060205
Pubmed	Interleukin-1β induced nuclear factor-κB binds to a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 promoter in human chondrosarcoma cells.	RELA IL1B	1.30e-05	3	73	2	25760020
Pubmed	Decreased toll-like receptor-4/myeloid differentiation factor 88 response leads to defective interleukin-1β production in term low birth weight newborns.	MYD88 IL1B	1.30e-05	3	73	2	25389708
Pubmed	Annexin A1 nuclear translocation induces retinal ganglion cell apoptosis after ischemia-reperfusion injury through the p65/IL-1β pathway.	RELA IL1B	1.30e-05	3	73	2	28389361
Pubmed	Exploring the association of interleukin polymorphisms with aggression and internalizing behaviors in children and adolescents.	IL1B IL2	1.30e-05	3	73	2	36168941
Pubmed	Lipopolysaccharide signaling without a nucleus: kinase cascades stimulate platelet shedding of proinflammatory IL-1β-rich microparticles.	MYD88 IL1B	1.30e-05	3	73	2	21430222
Pubmed	Macrophage-secreted factors induce adipocyte inflammation and insulin resistance.	RELA IL1B	1.30e-05	3	73	2	16427608
Pubmed	Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1α signaling and glutamine metabolism.	MYD88 IL1B	1.30e-05	3	73	2	36598999
Pubmed	Brain-derived neurotrophic factor is regulated via MyD88/NF-κB signaling in experimental Streptococcus pneumoniae meningitis.	MYD88 RELA	1.30e-05	3	73	2	28615695
Pubmed	Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection.	MYD88 IL1B	1.30e-05	3	73	2	29400698
Pubmed	Early-pregnancy cytokines in mothers to children developing multiple, persistent islet autoantibodies, type 1 diabetes, or both before 7 years of age.	IL1B IL2	1.30e-05	3	73	2	21819478
Pubmed	Can interleukin-2 and interleukin-1β be specific biomarkers of negative symptoms in schizophrenia?	IL1B IL2	1.30e-05	3	73	2	29724678
Pubmed	Silica-ceramic suppresses the expression of proinflammatory cytokines induced by lipopolysaccharide in macrophages.	RELA IL1B	1.30e-05	3	73	2	17133451
Pubmed	Influence of inflammasome NLRP3, and IL1B and IL2 gene polymorphisms in periodontitis susceptibility.	IL1B IL2	1.30e-05	3	73	2	31978095
Pubmed	Polymorphisms of interleukin-1 and interleukin-2 genes in patients with gastric cancer in Korea.	IL1B IL2	1.30e-05	3	73	2	18761558
Pubmed	Changes in toll-like receptor (TLR)4-NFκB-IL1β signaling in male gout patients might be involved in the pathogenesis of primary gouty arthritis.	RELA IL1B	1.30e-05	3	73	2	24036988
Pubmed	Involvement of interleukin-1β mediated nuclear factor κB signalling pathways to down-regulate prostate-specific antigen and cell proliferation in LNCaP prostate cancer cells.	RELA IL1B	1.30e-05	3	73	2	22103356
Pubmed	Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy.	MYD88 IL1B	1.30e-05	3	73	2	19762681
Pubmed	Nuclear RPSA senses viral nucleic acids to promote the innate inflammatory response.	SMARCA5 RELA	1.30e-05	3	73	2	38114488
Pubmed	Assessment of Alzheimer's disease case-control associations using family-based methods.	MYH13 MTHFR IL1B	1.33e-05	22	73	3	18830724
Pubmed	Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence.	MYD88 IL1B	2.60e-05	4	73	2	27409807
Pubmed	Interleukin-1 down-regulates gene and surface expression of interleukin-1 receptor type I by destabilizing its mRNA whereas interleukin-2 increases its expression.	IL1B IL2	2.60e-05	4	73	2	1533388
Pubmed	The Changes in the Expression of NF-KB in a Degenerative Human Intervertebral Disc model.	RELA IL1B	2.60e-05	4	73	2	25433723
Pubmed	Role of toll-like receptors in spontaneous commensal-dependent colitis.	MYD88 IL2	2.60e-05	4	73	2	16879997
Pubmed	Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound.	MYD88 IL1B	2.60e-05	4	73	2	17548806
Pubmed	Dynorphin 1-17 and Its N-Terminal Biotransformation Fragments Modulate Lipopolysaccharide-Stimulated Nuclear Factor-kappa B Nuclear Translocation, Interleukin-1beta and Tumor Necrosis Factor-alpha in Differentiated THP-1 Cells.	RELA IL1B	2.60e-05	4	73	2	27055013
Pubmed	IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway.	RELA IL1B	2.60e-05	4	73	2	21048223
Pubmed	In vivo ablation of NF-κB cascade effectors alleviates disease burden in myeloproliferative neoplasms.	MYD88 RELA	2.60e-05	4	73	2	38457657
Pubmed	NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.	RELA IL1B	2.60e-05	4	73	2	17803913
Pubmed	Serum IL-1beta, IL-2, and IL-6 in insulin-dependent diabetic children.	IL1B IL2	2.60e-05	4	73	2	16864906
Pubmed	Mechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signaling.	MYD88 IL1B	2.60e-05	4	73	2	30115681
Pubmed	Genetic causes of Parkinson's disease in the Maltese: a study of selected mutations in LRRK2, MTHFR, QDPR and SPR.	MTHFR LRRK2	2.60e-05	4	73	2	27613114
Pubmed	Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.	RASA4 RASA4B	2.60e-05	4	73	2	16234249
Pubmed	Polymorphisms in the MTHRF, VDR, MMP-9 and IL-β genes and the risk of premature rupture of membranes.	MTHFR IL1B	2.60e-05	4	73	2	20639647
Pubmed	Pro-inflammatory Cytokines Are Involved in Fluoride-Induced Cytotoxic Potential in HeLa Cells.	IL1B IL2	2.60e-05	4	73	2	27206670
Pubmed	IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct.	AHCYL1 SLC4A4	2.60e-05	4	73	2	19033647
Pubmed	Proinflammatory cytokine polymorphisms and the risk of preterm birth and low birthweight in a Japanese population.	IL1B IL2	2.60e-05	4	73	2	19141488
Pubmed	Production of IFN-γ by CD4(+) T cells in response to malaria antigens is IL-2 dependent.	MYD88 IL2	2.60e-05	4	73	2	21059770
Pubmed	Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells.	RELA IL2	2.60e-05	4	73	2	8207793
Pubmed	The JNk/NFkappaB pathway is required to activate murine lymphocytes induced by a sulfated polysaccharide from Ecklonia cava.	RELA IL2	2.60e-05	4	73	2	23262141
Pubmed	Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.	RASA4 RASA4B	2.60e-05	4	73	2	21460216
Pubmed	IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A+Foxp3+ Cells During Mucosal Infection and Is Dysregulated With Aging.	MYD88 IL1B	2.60e-05	4	73	2	33240286
Pubmed	The role of genetic variation across IL-1β, IL-2, IL-6, and BDNF in antipsychotic-induced weight gain.	IL1B IL2	2.60e-05	4	73	2	25560300
Pubmed	A noisy paracrine signal determines the cellular NF-kappaB response to lipopolysaccharide.	MYD88 RELA	2.60e-05	4	73	2	19843957
Pubmed	Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination.	IL1B IL2	2.60e-05	4	73	2	23009887
Pubmed	Commensal bacteria direct selective cargo sorting to promote symbiosis.	MYD88 LRRK2	2.60e-05	4	73	2	26237551
Pubmed	Inflammatory Response and Activation of Coagulation after COVID-19 Infection.	IL1B IL2	2.60e-05	4	73	2	37112918
Pubmed	Association between depression, parameters of adiposity and genetic polymorphisms of pro-inflammatory cytokines: IL-1α, IL-1β, IL-2 and IL-6 in subjects over 55 years old.	IL1B IL2	2.60e-05	4	73	2	26934083
Pubmed	Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance.	MYD88 IL2	2.60e-05	4	73	2	23791643
Pubmed	Interleukin-1α Mediates Ozone-Induced Myeloid Differentiation Factor-88-Dependent Epithelial Tissue Injury and Inflammation.	MYD88 IL1B	2.60e-05	4	73	2	29867931
Pubmed	Interleukin-1beta mediates the extra-intestinal thrombosis associated with experimental colitis.	MYD88 IL1B	2.60e-05	4	73	2	20971730
Pubmed	Chronic pain exacerbates memory impairment and pathology of Aβ and tau by upregulating IL-1β and p-65 signaling in a mouse model of Alzheimer's disease.	RELA IL1B	2.60e-05	4	73	2	38430996
Pubmed	The platelet glycoprotein Ia/IIa gene polymorphism C807T/G873A: a novel risk factor for retinal vein occlusion.	MTHFR ITGA2	2.60e-05	4	73	2	12928694
Pubmed	α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus-Infected Wounds.	MYD88 IL1B	2.60e-05	4	73	2	28733486
Pubmed	Pinellia ternata lectin exerts a pro-inflammatory effect on macrophages by inducing the release of pro-inflammatory cytokines, the activation of the nuclear factor-κB signaling pathway and the overproduction of reactive oxygen species.	RELA IL1B	2.60e-05	4	73	2	26310942
Pubmed	Allelic polymorphism of cytokine genes during pulmonary tuberculosis.	IL1B IL2	2.60e-05	4	73	2	20027321
Pubmed	MyD88-mediated signaling intercedes in neurogenic muscle atrophy through multiple mechanisms.	MYD88 RELA	2.60e-05	4	73	2	34325487
Pubmed	Oligodeoxynucleotides expressing polyguanosine motifs promote antitumor activity through the upregulation of IL-2.	MYD88 IL2	2.60e-05	4	73	2	23296706
Pubmed	IL-1β/NF-kb signaling promotes colorectal cancer cell growth through miR-181a/PTEN axis.	RELA IL1B	2.60e-05	4	73	2	27264420
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	SPCS3 SMARCA5 MYH13 GAR1 SULT2A1 ANXA6 TLN1 SMARCC2 EBNA1BP2 SNRPD2 DENND1A MPRIP	2.67e-05	1371	73	12	36244648
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	SMARCA5 POLA1 HMGXB4 SMC6 SMARCC2 SGO2 EBNA1BP2 PRDM15	4.13e-05	608	73	8	36089195
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4 RASA4B	3.60e-04	10	52	2	830
ToppCell	droplet-Marrow-nan-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRO POLA1 DIPK1A ANXA6 SMC6 EHD4	5.48e-07	182	73	6	bc8d621be57f76d718d9b0f11e023b0f4dcb668d
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MYH13 TOPAZ1 TLN1 LRRK2 PKHD1 IL1B	6.23e-07	186	73	6	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	AHCYL1 SLC13A1 PKHD1 EBNA1BP2 SLC4A4	1.05e-05	176	73	5	36f77d878a53b30465b0dea8333a3865dba75613
ToppCell	Severe-B_intermediate-10\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TLN1 SMC6 LRRK2 SNX18 NEB	1.11e-05	178	73	5	b7374a97c51239782bed658381a02cb1b3d9bf66
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1 SLC4A4 NEB RYR3 DNAH1	1.30e-05	184	73	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1 SLC4A4 NEB RYR3 DNAH1	1.30e-05	184	73	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1 SLC4A4 NEB RYR3 DNAH1	1.30e-05	184	73	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC13A1 PTPRO SLCO1A2 LRRK2 PKHD1	1.37e-05	186	73	5	f28d72b47624b69a580b4429e2be560a26898591
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial-Astrocyte\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	GAR1 ANXA6 RPGR ITGA2 NEB	1.94e-05	200	73	5	98a994692440cb4f505b050276f0c8022c814a21
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	GAR1 ANXA6 RPGR ITGA2 NEB	1.94e-05	200	73	5	ef222dc4a205d670172dae74990bdb952ac92e5b
Drug	tilomisole	POLA1 IL1B IL2	3.02e-07	5	72	3	CID000042747
Drug	Phosphorothioate Oligonucleotides	MYD88 RELA IL1B	3.58e-06	10	72	3	ctd:D054735
Drug	bafilomycin A1	ASIC1 LRRK2 RELA IL1B	3.97e-06	34	72	4	ctd:C040929
Drug	5-iodouracil	RASA4 SLCO1A2 RELA ITGA2	5.02e-06	36	72	4	CID000069672
Drug	9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol	MYD88 RELA IL1B	6.54e-06	12	72	3	ctd:C550091
Drug	SM360320	MYD88 IL1B	9.86e-06	2	72	2	CID010018576
Drug	Panax notoginseng extract	RELA IL1B IL2	1.08e-05	14	72	3	ctd:C519374
Drug	oxymatrine	RELA IL1B IL2	2.39e-05	18	72	3	ctd:C037573
Drug	FSL-1 lipoprotein, synthetic	MYD88 RELA IL1B	2.83e-05	19	72	3	ctd:C460864
Drug	paeonol	RELA IL1B IL2	2.83e-05	19	72	3	ctd:C013638
Drug	AC1LBMQA	IL1B IL2	2.95e-05	3	72	2	CID000538561
Drug	AC1O5QNB	IL1B IL2	2.95e-05	3	72	2	CID006438944
Drug	punarnavine	RELA IL1B IL2	3.87e-05	21	72	3	ctd:C526689
Drug	francium;germanium	MYD88 SLC13A1 RELA IL1B IL2	4.62e-05	124	72	5	CID006334320
Drug	3alpha, 7beta-dihydroxy-5beta-cholan-24-oic acid	SULT2A1 SLCO1A2 PKHD1 IL1B IL2 CYP46A1	4.85e-05	206	72	6	CID000005645
Drug	N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine	IL1B IL2	5.89e-05	4	72	2	ctd:C089665
Drug	timosaponin AIII	RELA IL1B	5.89e-05	4	72	2	ctd:C543146
Drug	Cholestanol	SULT2A1 CYP46A1	5.89e-05	4	72	2	ctd:D004083
Drug	IL-B	IFT172 ITGA2 IL1B IL2	6.06e-05	67	72	4	CID010342449
Drug	Kn 04	SLCO1A2 ITGA2 RYR3	7.48e-05	26	72	3	CID000131117
Drug	Coumpound 514	MYD88 RELA IL1B IL2	7.61e-05	71	72	4	CID000451715
Drug	Alum Compounds	MYD88 IL1B IL2	8.40e-05	27	72	3	ctd:D000534
Drug	Acetylmuramyl-Alanyl-Isoglutamine	MYD88 RELA IL1B	9.39e-05	28	72	3	ctd:D000119
Drug	Active Hexose Correlated Compound	MYD88 IL1B IL2	9.39e-05	28	72	3	ctd:C499366
Drug	4-coumaric acid	SULT2A1 RELA IL1B	9.39e-05	28	72	3	ctd:C032171
Drug	fumigaclavine C	IL1B IL2	9.80e-05	5	72	2	CID000173878
Drug	2-iodoethanol	POLA1 ITGA2	9.80e-05	5	72	2	CID000012225
Drug	lipostabil	RELA IL1B	9.80e-05	5	72	2	ctd:C005152
Drug	glyceryl-isoeugenol	RELA IL1B	9.80e-05	5	72	2	ctd:C560287
Drug	EVP 4593	RELA IL1B	9.80e-05	5	72	2	ctd:C562064
Drug	catalposide	RELA IL1B	9.80e-05	5	72	2	CID000093039
Drug	pinitol	RELA IL1B	9.80e-05	5	72	2	ctd:C021730
Drug	betamethasone butyrate propionate	IL1B IL2	9.80e-05	5	72	2	CID000071470
Drug	protoberberine	IL1B IL2	9.80e-05	5	72	2	ctd:C009090
Drug	salicylhydroxamic acid	MYD88 PTPRO RELA IL1B RYR3	1.00e-04	146	72	5	CID000066644
Drug	Adjuvants, Immunologic	MYD88 RELA IL1B	1.16e-04	30	72	3	ctd:D000276
Drug	L IL	MYD88 IL1B IL2	1.28e-04	31	72	3	CID000445571
Drug	AC1L1YB5	RELA IL1B IL2	1.28e-04	31	72	3	CID000037723
Drug	AEAD	IL1B IL2	1.47e-04	6	72	2	CID000125982
Drug	IDR-E804	MYD88 IL1B	1.47e-04	6	72	2	CID006419764
Drug	Cetylpyridinium	RELA IL1B	1.47e-04	6	72	2	ctd:D002594
Drug	2'-chloro-2'-deoxyadenosine	POLA1 ITGA2	1.47e-04	6	72	2	CID000100327
Drug	toxB protein, Clostridium difficile	RELA IL1B	1.47e-04	6	72	2	ctd:C031815
Drug	gigantol	RELA IL1B	1.47e-04	6	72	2	ctd:C478099
Drug	Pro-Leu-Ser-Arg-Thr-Leu-Ser-Val-Ala-Ala-Lys-Lys	IL1B IL2	1.47e-04	6	72	2	CID003277749
Drug	orazipone	RELA IL1B	1.47e-04	6	72	2	ctd:C502617
Drug	monocyte locomotion inhibitory factor	IL1B IL2	1.47e-04	6	72	2	ctd:C430647
Drug	fumigaclavine C	IL1B IL2	1.47e-04	6	72	2	ctd:C492995
Drug	AC1L7I6E	TARS3 TARS1	1.47e-04	6	72	2	CID000310900
Drug	ADA 202-718	IL1B IL2	1.47e-04	6	72	2	CID000128568
Drug	KB-26843	IL1B IL2	1.47e-04	6	72	2	CID010265111
Drug	BRL 44408	IL1B IL2	1.47e-04	6	72	2	ctd:C072125
Drug	scropolioside A	IL1B IL2	1.47e-04	6	72	2	CID006449923
Drug	H2DIDS	AGXT ITGA2 SLC4A4	1.55e-04	33	72	3	CID000115184
Drug	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	MYD88 RELA IL1B	1.69e-04	34	72	3	ctd:C507035
Drug	glyceryl 2-arachidonate	RELA IL1B IL2	1.85e-04	35	72	3	ctd:C094503
Drug	Humic Substances	RELA ITGA2 IL1B	2.01e-04	36	72	3	ctd:D006812
Drug	Titanium	MYD88 RELA IL1B	2.01e-04	36	72	3	ctd:D014025
Drug	Fk 565	MYD88 IL1B IL2	2.01e-04	36	72	3	CID000115204
Drug	Apomab	MYD88 IL2 SNRPD2	2.01e-04	36	72	3	CID000072231
Drug	dihydrocucurbitacin B	IL1B IL2	2.05e-04	7	72	2	CID000267250
Drug	lancemaside A	RELA IL1B	2.05e-04	7	72	2	ctd:C533150
Drug	Ro 14-6113	IL1B IL2	2.05e-04	7	72	2	CID006439236
Drug	Klebsiella O3 lipopolysaccharide	RELA IL1B	2.05e-04	7	72	2	ctd:C043237
Drug	enterotoxin F, Staphylococcal	IL1B IL2	2.05e-04	7	72	2	ctd:C030107
Drug	4-methylesculetin	IL1B IL2	2.05e-04	7	72	2	ctd:C570020
Drug	7-hydroxymethotrexate	MTHFR SLCO1A2	2.05e-04	7	72	2	ctd:C011864
Drug	nitroflurbiprofen	RELA IL1B	2.05e-04	7	72	2	ctd:C095631
Drug	5-(N-methyl-N-isobutyl)amiloride	RELA IL1B	2.05e-04	7	72	2	ctd:C056369
Drug	asarone	RELA IL1B	2.05e-04	7	72	2	ctd:C012195
Drug	bis(3-hydroxyphenyl) diselenide	RELA IL1B	2.05e-04	7	72	2	ctd:C541028
Drug	lithospermate B	RELA IL1B	2.05e-04	7	72	2	ctd:C061091
Drug	Oligodeoxyribonucleotides	RELA IL2	2.05e-04	7	72	2	ctd:D009838
Drug	petrosaspongiolide m	RELA IL1B	2.05e-04	7	72	2	ctd:C118309
Drug	aluminum phosphate	MYD88 IL1B	2.05e-04	7	72	2	ctd:C012714
Drug	CHEBI:564108	ITGA2 RYR3	2.05e-04	7	72	2	CID006400637
Drug	Fluticasone	RELA IL1B IL2	2.18e-04	37	72	3	ctd:D000068298
Drug	sIL-4R	RELA IL1B IL2	2.18e-04	37	72	3	CID000059757
Drug	Nb d	MYD88 SLCO1A2 EXOC3 IL1B IL2	2.28e-04	174	72	5	CID000445938
Drug	Eicosapentaenoic Acid	SLC13A1 RELA IL1B IL2	2.45e-04	96	72	4	ctd:D015118
Drug	Histamine	RELA ITGA2 IL1B IL2	2.65e-04	98	72	4	ctd:D006632
Drug	2-chloro-4'-methoxychalcone	RELA IL1B	2.73e-04	8	72	2	ctd:C570406
Drug	alternaramide	MYD88 IL1B	2.73e-04	8	72	2	ctd:C545596
Drug	dexamethasone 21-phosphate	RELA IL1B	2.73e-04	8	72	2	ctd:C004180
Drug	epoxiconazole	IFT172 AGXT	2.73e-04	8	72	2	CID000107901
Drug	RbBr	ITGA2 CYP46A1	2.73e-04	8	72	2	CID004670918
Drug	2-anisidine	MYD88 RELA IL1B IL2	2.76e-04	99	72	4	ctd:C003898
Drug	imidazoquinoline	MYD88 RELA IL1B SNRPD2	2.98e-04	101	72	4	CID005351568
Drug	Peptidoglycan	MYD88 RELA IL1B	3.19e-04	42	72	3	ctd:D010457
Drug	Poly I-C	MYD88 RELA IL1B IL2	3.45e-04	105	72	4	ctd:D011070
Drug	6,2',4'-trimethoxyflavone	RELA IL1B	3.50e-04	9	72	2	ctd:C546607
Drug	K-12 lipopolysaccharide	MYD88 IL1B	3.50e-04	9	72	2	ctd:C114999
Drug	monotropein	RELA IL1B	3.50e-04	9	72	2	ctd:C507582
Drug	juzentaihoto	RELA IL1B	3.50e-04	9	72	2	ctd:C063587
Drug	Zyflamend	RELA IL1B	3.50e-04	9	72	2	ctd:C519312
Drug	gliovirin	IL1B IL2	3.50e-04	9	72	2	CID000158472
Drug	7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid	RELA IL1B	3.50e-04	9	72	2	ctd:C535211
Drug	7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(3-piperidinyl)-1,4-dihydro-2H-pyrido(2,3-d)(1,3)oxazin-2-one	RELA IL1B	3.50e-04	9	72	2	ctd:C502972
Drug	RU24858	RELA IL1B	3.50e-04	9	72	2	ctd:C000589029
Drug	flavokawain A	RELA IL1B	3.50e-04	9	72	2	ctd:C500809
Disease	Brain Ischemia	ASIC1 MTHFR RELA IL1B	1.43e-05	60	72	4	C0007786
Disease	Cerebral Ischemia	ASIC1 MTHFR RELA IL1B	1.43e-05	60	72	4	C0917798
Disease	Morbilliform Drug Reaction	MTHFR RELA IL2	2.38e-05	23	72	3	C0406537
Disease	Drug Eruptions	MTHFR RELA IL2	2.38e-05	23	72	3	C0011609
Disease	amino acid metabolic disorder (implicated_via_orthology)	TARS3 TARS1	3.51e-05	4	72	2	DOID:9252 (implicated_via_orthology)
Disease	X-13429 measurement	SULT2A1 SLCO1A2	3.51e-05	4	72	2	EFO_0021348
Disease	thrombocytopenia (is_implicated_in)	MTHFR ITGA2 IL1B	3.91e-05	27	72	3	DOID:1588 (is_implicated_in)
Disease	eye disease (is_implicated_in)	MTHFR IL1B	5.84e-05	5	72	2	DOID:5614 (is_implicated_in)
Disease	progressive supranuclear palsy	SLCO1A2 IL2 EHD4	5.96e-05	31	72	3	MONDO_0019037
Disease	Cholestasis, Extrahepatic	MYD88 RELA IL1B	6.57e-05	32	72	3	C0005398
Disease	hepatocellular carcinoma (is_implicated_in)	MYD88 MTHFR IL1B IL2 RYR3	8.24e-05	181	72	5	DOID:684 (is_implicated_in)
Disease	Entamoeba histolytica Infection	IL1B IL2	8.75e-05	6	72	2	C4316791
Disease	Entamoebiasis	IL1B IL2	8.75e-05	6	72	2	C0014324
Disease	Dermatomyositis, Childhood Type	C9 IL1B	8.75e-05	6	72	2	C0263666
Disease	Adult type dermatomyositis	C9 IL1B	8.75e-05	6	72	2	C0221056
Disease	Dermatomyositis	C9 IL1B	8.75e-05	6	72	2	C0011633
Disease	Neoplasm Invasiveness	MYD88 PPP1R12B TLN1 RELA IL1B	8.91e-05	184	72	5	C0027626
Disease	Graves' disease (is_implicated_in)	MTHFR IL1B IL2	1.20e-04	39	72	3	DOID:12361 (is_implicated_in)
Disease	retinal vein occlusion (is_implicated_in)	MTHFR ITGA2	1.22e-04	7	72	2	DOID:1727 (is_implicated_in)
Disease	arteriosclerosis (biomarker_via_orthology)	RELA IL1B	1.63e-04	8	72	2	DOID:2349 (biomarker_via_orthology)
Disease	cystitis (implicated_via_orthology)	IL1B IL2	1.63e-04	8	72	2	DOID:1679 (implicated_via_orthology)
Disease	Inflammatory disease of mucous membrane	MTHFR IL1B	1.63e-04	8	72	2	C0333355
Disease	Hematological Disease	GAR1 MTHFR	1.63e-04	8	72	2	C0018939
Disease	Leukopenia	MTHFR IL2	1.63e-04	8	72	2	C0023530
Disease	theophylline measurement	LRRK2 ITGA2	2.61e-04	10	72	2	EFO_0021180
Disease	Inflammation	MYD88 PLAA ASIC1 IL1B	2.68e-04	127	72	4	C0021368
Disease	pregnenediol disulfate (C21H34O8S2) measurement	SULT2A1 SLCO1A2	3.18e-04	11	72	2	EFO_0800279
Disease	diffuse large B-cell lymphoma (is_implicated_in)	MYD88 MTHFR	3.81e-04	12	72	2	DOID:0050745 (is_implicated_in)
Disease	esophageal cancer (is_marker_for)	MYD88 IL1B	3.81e-04	12	72	2	DOID:5041 (is_marker_for)
Disease	Short Rib-Polydactyly Syndrome	IFT172 KIAA0586	4.50e-04	13	72	2	C0036996
Disease	systemic lupus erythematosus (is_implicated_in)	IL1B IL2 SNRPD2	4.75e-04	62	72	3	DOID:9074 (is_implicated_in)
Disease	chronic kidney disease (is_implicated_in)	MTHFR IL1B	5.24e-04	14	72	2	DOID:784 (is_implicated_in)
Disease	Saldino-Noonan Syndrome	IFT172 KIAA0586	5.24e-04	14	72	2	C0036069
Disease	Majewski Syndrome	IFT172 KIAA0586	5.24e-04	14	72	2	C0024507
Disease	quinate measurement	LRRK2 ITGA2	6.04e-04	15	72	2	EFO_0021167
Disease	Lymphoma, Follicular, Grade 2	MYD88 MTHFR	6.04e-04	15	72	2	C1956132
Disease	Lymphoma, Follicular, Grade 3	MYD88 MTHFR	6.04e-04	15	72	2	C1956131
Disease	Lymphoma, Follicular, Grade 1	MYD88 MTHFR	6.04e-04	15	72	2	C1956130
Disease	Lymphoma, Large-Cell, Follicular	MYD88 MTHFR	6.04e-04	15	72	2	C0079745
Disease	Lymphoma, Small Cleaved-Cell, Follicular	MYD88 MTHFR	6.04e-04	15	72	2	C0079765
Disease	Lymphoma, Mixed-Cell, Follicular	MYD88 MTHFR	6.04e-04	15	72	2	C0079758
Disease	renal cell carcinoma (is_implicated_in)	MTHFR RELA IL2	6.50e-04	69	72	3	DOID:4450 (is_implicated_in)
Disease	Diabetic Angiopathies	MTHFR RELA	6.89e-04	16	72	2	C0011875
Disease	Microangiopathy, Diabetic	MTHFR RELA	6.89e-04	16	72	2	C0025945
Disease	diabetic neuropathy (biomarker_via_orthology)	LRRK2 IL1B	7.80e-04	17	72	2	DOID:9743 (biomarker_via_orthology)
Disease	graft-versus-host disease (is_implicated_in)	MTHFR IL2	7.80e-04	17	72	2	DOID:0081267 (is_implicated_in)
Disease	feeling "fed-up" measurement	PROX2 ITSN2 IL2	8.62e-04	76	72	3	EFO_0009588
Disease	sinusitis (is_marker_for)	IL1B IL2	8.76e-04	18	72	2	DOID:0050127 (is_marker_for)
Disease	Anorexia	IL1B IL2	8.76e-04	18	72	2	C0003123
Disease	squamous cell carcinoma (is_implicated_in)	MTHFR IL2	8.76e-04	18	72	2	DOID:1749 (is_implicated_in)
Disease	non-alcoholic fatty liver disease (is_implicated_in)	MTHFR IL1B	8.76e-04	18	72	2	DOID:0080208 (is_implicated_in)
Disease	metabolonic lactone sulfate measurement	SULT2A1 SLCO1A2	9.77e-04	19	72	2	EFO_0800659
Disease	Lymphoma, Follicular	MYD88 MTHFR	1.08e-03	20	72	2	C0024301
Disease	type 1 diabetes mellitus (is_implicated_in)	MTHFR IL1B IL2	1.19e-03	85	72	3	DOID:9744 (is_implicated_in)
Disease	epilepsy (biomarker_via_orthology)	RELA IL1B	1.20e-03	21	72	2	DOID:1826 (biomarker_via_orthology)
Disease	Deep Vein Thrombosis	MTHFR F13B	1.20e-03	21	72	2	C0149871
Disease	Venous Thrombosis	MTHFR F13B	1.20e-03	21	72	2	C0042487
Disease	Neutropenia	MTHFR IL1B	1.20e-03	21	72	2	C0027947
Disease	hepatitis B (is_marker_for)	MYD88 IL2	1.20e-03	21	72	2	DOID:2043 (is_marker_for)
Disease	status epilepticus (implicated_via_orthology)	RELA IL1B	1.20e-03	21	72	2	DOID:1824 (implicated_via_orthology)
Disease	Reperfusion Injury	MYD88 RELA IL1B	1.36e-03	89	72	3	C0035126
Disease	trans fatty acid measurement, trans/trans-18:2 fatty acid measurement	DIPK1A RYR3	1.57e-03	24	72	2	EFO_0006821, EFO_0006826
Disease	uveitis (biomarker_via_orthology)	RELA IL1B	1.70e-03	25	72	2	DOID:13141 (biomarker_via_orthology)
Disease	Colitis	RELA IL1B	1.70e-03	25	72	2	C0009319
Disease	anogenital venereal wart (is_marker_for)	MYD88 IL2	1.84e-03	26	72	2	DOID:11168 (is_marker_for)
Disease	acute necrotizing pancreatitis (biomarker_via_orthology)	RELA IL1B	1.84e-03	26	72	2	DOID:0080998 (biomarker_via_orthology)
Disease	Acute Confusional Senile Dementia	MTHFR IL1B CYP46A1	1.85e-03	99	72	3	C0546126
Disease	Alzheimer's Disease, Focal Onset	MTHFR IL1B CYP46A1	1.85e-03	99	72	3	C0750900
Disease	Alzheimer Disease, Early Onset	MTHFR IL1B CYP46A1	1.85e-03	99	72	3	C0750901
Disease	Presenile dementia	MTHFR IL1B CYP46A1	1.85e-03	99	72	3	C0011265
Disease	Alzheimer Disease, Late Onset	MTHFR IL1B CYP46A1	1.85e-03	99	72	3	C0494463
Disease	Familial Alzheimer Disease (FAD)	MTHFR IL1B CYP46A1	1.90e-03	100	72	3	C0276496
Disease	Alzheimer's Disease	MTHFR IL1B CYP46A1	1.96e-03	101	72	3	C0002395
Disease	Fever	IL1B IL2	1.98e-03	27	72	2	C0015967
Disease	oral squamous cell carcinoma (is_implicated_in)	MTHFR IL2	2.13e-03	28	72	2	DOID:0050866 (is_implicated_in)
Disease	obstructive sleep apnea (is_marker_for)	RELA IL1B	2.28e-03	29	72	2	DOID:0050848 (is_marker_for)
Disease	Parkinsonism (implicated_via_orthology)	RELA IL1B	2.28e-03	29	72	2	DOID:0080855 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KKKESLADQFDFKMY	C6orf62	21	Q9GZU0
ITKMLKFSSKEKYPL	ATG4C	401	Q96DT6
SFYKKLLPFKMKSTT	CCNB3	616	Q8WWL7
PLFFADKLYKSMKGA	ANXA6	601	P08133
KGPLMSSSFKKLYFS	RASA4	581	O43374
KGPLMSSSFKKLYFS	RASA4B	581	C9J798
SKMASKAKKIFAEYI	RGS3	1116	P49796
KLFSSKSNAQFKMYK	ITSN2	1476	Q9NZM3
KSNAQFKMYKTPIFL	ITSN2	1481	Q9NZM3
PFKGIKYMTKAGKFQ	AP3M2	401	P53677
YPKKKMEKRFVFNKI	IL1B	206	P01584
FYLKSKSPKEELLKM	MTHFR	406	P42898
FFMYAKPKSQDLLGK	OR13C4	256	Q8NGS5
YDIMKSKSNPDFLKK	MPRIP	986	Q6WCQ1
QKMKYRPPKTKFFFT	CFAP65	176	Q6ZU64
MKKKFSSYLGNGFQK	CCDC190	66	Q86UF4
MNAIKKYQKGFSDKL	EBNA1BP2	196	Q99848
TFKSFYFPMSIDKKL	F13B	41	P05160
KYKAMKKEFPSILRF	MYD88	256	Q99836
SKKRKFPKNYMSQYF	LRRK2	1636	Q5S007
YLKKEMPSVFGKENK	EHD4	316	Q9H223
PKKKNMSAYQVFCKE	HMGXB4	406	Q9UGU5
LGFFKRKYEKMTKNP	ITGA2	1156	P17301
KIMKFKSKPVEKNYA	POLA1	426	P09884
KMSPKDLFEQRKKYS	EPS8L2	26	Q9H6S3
DKFSTKPADMKYGRK	IFT172	51	Q9UG01
KDFRTMLYKDFFKGK	PTPRO	161	Q16827
KKAKLMFFFTRYPSS	PROX2	446	Q3B8N5
DLYKFAEEMKFSKKL	DNAH1	3686	Q9P2D7
TFKFYMPKKATELKH	IL2	61	P60568
YKKSSKMVFKAPIKE	CORO2B	401	Q9UQ03
ESVKKFLMSTKYNKD	CYP46A1	91	Q9Y6A2
LYKKDCFKAAPFSMF	IDI2-AS1	171	Q9NZ38
TKANPAMKTVYKFAK	DENND1A	421	Q8TEH3
NDFAKIKKPYKKRMT	EXOC3	581	O60645
VQKFKEMVYSLFKAK	DIPK1A	146	Q5T7M9
IMPSKKVASAYFKDF	SLC13A1	71	Q9BZW2
GFKPKMYCRKYKATL	CFAP47	3101	Q6ZTR5
QLFLSYSSKKEKMFL	C9	281	P02748
AMKKTFFSKLYPEKN	OR10H1	301	Q9Y4A9
KNAFMKVVEKAKYSL	OR5B17	296	Q8NGF7
KKMNPRSTEAAIKYF	MT-ND2	46	P03891
KPIISKSMAKYDFKC	RPGR	771	Q92834
ENMKASSFKKLQKFY	GAR1	131	Q9NY12
SKEILLEMFKYNKFK	TARS3	301	A2RTX5
VKKETLLAMFKYNKF	TARS1	221	P26639
IYFLSSKETKEKFMK	AK9	1381	Q5TCS8
SKETKEKFMKNPIKY	AK9	1386	Q5TCS8
AKKKMYSRKTKPFSF	AGXT	226	P21549
LASEFFKKDKLMYKE	SLFN14	186	P0C7P3
FKKDKLMYKEKLNFT	SLFN14	191	P0C7P3
KSKPVNKDRYISKMF	SNRPD2	86	P62316
EKYSFMATVTKAPKK	AHCYL1	26	O43865
AFYAKKMDKPMLKQA	PRDM15	526	P57071
PKLLLKDMKTKYFFF	SPCS3	116	P61009
NEKMVKNKPDFYTKA	SGO2	1121	Q562F6
MLKIKDKNKFYFPSL	PKHD1	3316	P08F94
KEKYGITKDFLPFMK	SLCO1A2	296	P46721
PKSFFSSKAKVIYLM	SULT2A1	106	Q06520
YFFWKNMKFIKKPKS	SULT2A1	131	Q06520
MYTKKNVPSKSKAAA	SMARCC2	581	Q8TAQ2
IPSKASAKYLAKKFN	ASIC1	381	P78348
KVKDYEKKKSMPSFV	USP16	341	Q9Y5T5
LFKATMLTDKYKQGK	RALGAPA1	1131	Q6GYQ0
KMLDYLKEKKDAGFF	RYR3	3666	Q15413
KTYGVSFFLVKEKMK	TLN1	306	Q9Y490
DDPTKQTKFKGMKSY	SNX18	281	Q96RF0
AASKTMNIYFPKKEA	PLAA	526	Q9Y263
MFPKATDTSFKNKLY	MYH13	541	Q9UKX3
KNEGDKYKFFMKATQ	SMC6	201	Q96SB8
KYKFFMKATQLEQMK	SMC6	206	Q96SB8
FKSMKSFIGKSPNEY	TOPAZ1	446	Q8N9V7
SSMALKKFKTSPYFP	SLC4A4	706	Q9Y6R1
LFFNTPKKMTDYAKK	PSMD8	291	P48556
SYEMLIKEKSVFKKF	SMARCA5	286	O60264
YETFKSIMKKSPFSG	RELA	306	Q04206
QTDFYATKPKKMDSK	KIAA0586	681	Q9BVV6
KIQSGFFKNKEKMLY	PPP1R12B	326	O60237
KMQDLFSPNKYKEKF	NEB	91	P20929
FSPNKYKEKFEKTKG	NEB	96	P20929