Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	endopeptidase activity	ADAMTS12 PRSS53 ADAMTS9 PRSS12 CELA2A ADAMTS20 ADAMTS8 CELA2B BACE2 ESPL1	4.06e-06	430	74	10	GO:0004175
GeneOntologyMolecularFunction	extracellular matrix structural constituent	THSD4 VWF SPON1 PAPLN DMBT1 FGL2	7.00e-05	188	74	6	GO:0005201
GeneOntologyMolecularFunction	peptidase activity	ADAMTS12 PRSS53 ADAMTS9 PRSS12 CELA2A ADAMTS20 ADAMTS8 CELA2B BACE2 ESPL1	1.44e-04	654	74	10	GO:0008233
GeneOntologyMolecularFunction	N-acylsphingosine amidohydrolase activity	ASAH2 ASAH2B	2.81e-04	7	74	2	GO:0017040
GeneOntologyMolecularFunction	fatty-acyl-CoA synthase activity	ACSM3 ACSM1	3.74e-04	8	74	2	GO:0004321
GeneOntologyMolecularFunction	medium-chain fatty acid-CoA ligase activity	ACSM3 ACSM1	7.29e-04	11	74	2	GO:0031956
GeneOntologyMolecularFunction	metalloendopeptidase activity	ADAMTS12 ADAMTS9 ADAMTS20 ADAMTS8	1.03e-03	120	74	4	GO:0004222
GeneOntologyMolecularFunction	G protein-coupled photoreceptor activity	OPN5 GPR52	1.38e-03	15	74	2	GO:0008020
GeneOntologyBiologicalProcess	extracellular matrix organization	ADAMTS12 THSD4 QSOX1 ADAMTS9 ADAMTS20 PAPLN ADAMTS8 ADAMTSL3	6.71e-05	377	75	8	GO:0030198
GeneOntologyBiologicalProcess	extracellular structure organization	ADAMTS12 THSD4 QSOX1 ADAMTS9 ADAMTS20 PAPLN ADAMTS8 ADAMTSL3	6.84e-05	378	75	8	GO:0043062
GeneOntologyBiologicalProcess	external encapsulating structure organization	ADAMTS12 THSD4 QSOX1 ADAMTS9 ADAMTS20 PAPLN ADAMTS8 ADAMTSL3	6.96e-05	379	75	8	GO:0045229
GeneOntologyBiologicalProcess	ceramide catabolic process	ASAH2 LCT ASAH2B	1.13e-04	26	75	3	GO:0046514
GeneOntologyBiologicalProcess	positive regulation of melanocyte differentiation	ADAMTS9 ADAMTS20	1.30e-04	5	75	2	GO:0045636
GeneOntologyCellularComponent	extracellular matrix	ADAMTS12 THSD4 FCGBP VWF ADAMTS9 SPON1 CELA2A ADAMTS20 PAPLN ADAMTS8 CELA2B DMBT1 ADAMTSL3 MARCO FGL2	1.16e-08	656	76	15	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	ADAMTS12 THSD4 FCGBP VWF ADAMTS9 SPON1 CELA2A ADAMTS20 PAPLN ADAMTS8 CELA2B DMBT1 ADAMTSL3 MARCO FGL2	1.21e-08	658	76	15	GO:0030312
GeneOntologyCellularComponent	collagen-containing extracellular matrix	THSD4 VWF ADAMTS9 SPON1 CELA2A ADAMTS20 PAPLN ADAMTS8 CELA2B DMBT1 MARCO FGL2	4.42e-07	530	76	12	GO:0062023
GeneOntologyCellularComponent	keratohyalin granule	CELA2A CELA2B	1.30e-04	5	76	2	GO:0036457
GeneOntologyCellularComponent	membrane attack complex	C6 C8A	2.71e-04	7	76	2	GO:0005579
MousePheno	abnormal parasympathetic nervous system physiology	CPEB2 CELA2A CELA2B ROBO3	1.29e-07	11	64	4	MP:0006277
MousePheno	abnormal postsynaptic density morphology	CTTNBP2 NRXN3 ADGRB1 GPRASP2	6.48e-06	27	64	4	MP:0020551
MousePheno	abnormal asymmetric synapse morphology	CTTNBP2 NRXN3 ADGRB1 GPRASP2	7.53e-06	28	64	4	MP:0020360
MousePheno	abnormal autonomic nervous system physiology	CPEB2 CELA2A CELA2B ROBO3	4.31e-05	43	64	4	MP:0006276
Domain	TSP_1	ADAMTS12 THSD4 UNC5A SEMA5B ADAMTS9 SPON1 ISM1 ADGRB1 ADGRB3 ADAMTS20 PAPLN ADAMTS8 C6 C8A ADAMTSL3	1.73e-23	63	73	15	PF00090
Domain	TSP1	ADAMTS12 THSD4 UNC5A SEMA5B ADAMTS9 SPON1 ISM1 ADGRB1 ADGRB3 ADAMTS20 PAPLN ADAMTS8 C6 C8A ADAMTSL3	2.92e-23	65	73	15	SM00209
Domain	TSP1_rpt	ADAMTS12 THSD4 UNC5A SEMA5B ADAMTS9 SPON1 ISM1 ADGRB1 ADGRB3 ADAMTS20 PAPLN ADAMTS8 C6 C8A ADAMTSL3	2.92e-23	65	73	15	IPR000884
Domain	TSP1	ADAMTS12 THSD4 UNC5A SEMA5B ADAMTS9 SPON1 ISM1 ADGRB1 ADGRB3 ADAMTS20 PAPLN ADAMTS8 C6 C8A ADAMTSL3	2.92e-23	65	73	15	PS50092
Domain	ADAM_spacer1	ADAMTS12 THSD4 ADAMTS9 ADAMTS20 PAPLN ADAMTS8	2.77e-10	23	73	6	IPR010294
Domain	ADAM_spacer1	ADAMTS12 THSD4 ADAMTS9 ADAMTS20 PAPLN ADAMTS8	2.77e-10	23	73	6	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS12 ADAMTS9 ADAMTS20 PAPLN ADAMTS8 ADAMTSL3	3.68e-10	24	73	6	IPR013273
Domain	PLAC	ADAMTS12 THSD4 PAPLN ADAMTSL3	7.96e-07	19	73	4	PS50900
Domain	PLAC	ADAMTS12 THSD4 PAPLN ADAMTSL3	7.96e-07	19	73	4	IPR010909
Domain	Ceramidse_alk_C	ASAH2 ASAH2B	1.51e-05	2	73	2	PF17048
Domain	Pept_M12B_GON-ADAMTSs	ADAMTS9 ADAMTS20	1.51e-05	2	73	2	IPR012314
Domain	GON	ADAMTS9 ADAMTS20	1.51e-05	2	73	2	PF08685
Domain	NEUT/ALK_ceramidase_C	ASAH2 ASAH2B	1.51e-05	2	73	2	IPR031331
Domain	GON	ADAMTS9 ADAMTS20	1.51e-05	2	73	2	PS51046
Domain	Ceramidase_alk	ASAH2 ASAH2B	1.51e-05	2	73	2	IPR006823
Domain	Peptidase_M12B_N	ADAMTS12 ADAMTS9 ADAMTS20 ADAMTS8	1.59e-05	39	73	4	IPR002870
Domain	Pep_M12B_propep	ADAMTS12 ADAMTS9 ADAMTS20 ADAMTS8	1.59e-05	39	73	4	PF01562
Domain	DISINTEGRIN_1	ADAMTS12 ADAMTS9 ADAMTS20 ADAMTS8	1.76e-05	40	73	4	PS00427
Domain	Reprolysin	ADAMTS12 ADAMTS9 ADAMTS20 ADAMTS8	1.76e-05	40	73	4	PF01421
Domain	ADAM_MEPRO	ADAMTS12 ADAMTS9 ADAMTS20 ADAMTS8	1.76e-05	40	73	4	PS50215
Domain	DISINTEGRIN_2	ADAMTS12 ADAMTS9 ADAMTS20 ADAMTS8	1.76e-05	40	73	4	PS50214
Domain	Peptidase_M12B	ADAMTS12 ADAMTS9 ADAMTS20 ADAMTS8	1.76e-05	40	73	4	IPR001590
Domain	Disintegrin_dom	ADAMTS12 ADAMTS9 ADAMTS20 ADAMTS8	1.95e-05	41	73	4	IPR001762
Domain	PLAC	THSD4 PAPLN ADAMTSL3	2.02e-05	14	73	3	PF08686
Domain	GPCR_2_brain_angio_inhib	ADGRB1 ADGRB3	4.51e-05	3	73	2	IPR008077
Domain	SRCR	PRSS12 DMBT1 MARCO	7.24e-05	21	73	3	PF00530
Domain	SR	PRSS12 DMBT1 MARCO	1.24e-04	25	73	3	SM00202
Domain	-	PRSS12 DMBT1 MARCO	1.24e-04	25	73	3	3.10.250.10
Domain	SRCR_1	PRSS12 DMBT1 MARCO	1.40e-04	26	73	3	PS00420
Domain	SRCR_2	PRSS12 DMBT1 MARCO	1.40e-04	26	73	3	PS50287
Domain	SRCR-like_dom	PRSS12 DMBT1 MARCO	1.40e-04	26	73	3	IPR017448
Domain	SRCR	PRSS12 DMBT1 MARCO	1.57e-04	27	73	3	IPR001190
Domain	MACPF_CS	C6 C8A	2.24e-04	6	73	2	IPR020863
Domain	MetalloPept_cat_dom	ADAMTS12 ADAMTS9 ADAMTS20 ADAMTS8	2.85e-04	81	73	4	IPR024079
Domain	-	ADAMTS12 ADAMTS9 ADAMTS20 ADAMTS8	2.85e-04	81	73	4	3.40.390.10
Domain	MACPF_2	C6 C8A	3.12e-04	7	73	2	PS51412
Domain	MACPF_1	C6 C8A	3.12e-04	7	73	2	PS00279
Domain	TRYPSIN_SER	PRSS53 PRSS12 CELA2A CELA2B	4.26e-04	90	73	4	IPR033116
Domain	ZINC_PROTEASE	ADAMTS12 ADAMTS9 ADAMTS20 ADAMTS8	5.88e-04	98	73	4	PS00142
Domain	MAC_perforin	C6 C8A	6.64e-04	10	73	2	IPR001862
Domain	F-box-like	FBXW2 SKP2 FBXL5	6.76e-04	44	73	3	PF12937
Domain	TRYPSIN_HIS	PRSS53 PRSS12 CELA2A CELA2B	7.09e-04	103	73	4	IPR018114
Domain	TRYPSIN_SER	PRSS53 PRSS12 CELA2A CELA2B	7.90e-04	106	73	4	PS00135
Domain	MACPF	C6 C8A	8.10e-04	11	73	2	PF01823
Domain	GAIN_dom_N	ADGRB1 ADGRB3	8.10e-04	11	73	2	IPR032471
Domain	GAIN	ADGRB1 ADGRB3	8.10e-04	11	73	2	PF16489
Domain	TRYPSIN_HIS	PRSS53 PRSS12 CELA2A CELA2B	8.18e-04	107	73	4	PS00134
Domain	TIL	FCGBP VWF	9.70e-04	12	73	2	PF01826
Domain	MACPF	C6 C8A	9.70e-04	12	73	2	SM00457
Domain	MACPF	C6 C8A	9.70e-04	12	73	2	IPR020864
Domain	C8	FCGBP VWF	9.70e-04	12	73	2	PF08742
Domain	Peptidase_S1A	PRSS53 PRSS12 CELA2A CELA2B	1.00e-03	113	73	4	IPR001314
Domain	TRYPSIN_DOM	PRSS53 PRSS12 CELA2A CELA2B	1.07e-03	115	73	4	PS50240
Domain	FBOX	FBXW2 SKP2 FBXL5	1.10e-03	52	73	3	SM00256
Domain	Tryp_SPc	PRSS53 PRSS12 CELA2A CELA2B	1.14e-03	117	73	4	SM00020
Domain	Unchr_dom_Cys-rich	FCGBP VWF	1.14e-03	13	73	2	IPR014853
Domain	C8	FCGBP VWF	1.14e-03	13	73	2	SM00832
Domain	CUB	ADGRB3 DMBT1 SEZ6L	1.17e-03	53	73	3	PS01180
Domain	Trypsin	PRSS53 PRSS12 CELA2A CELA2B	1.29e-03	121	73	4	PF00089
Domain	Trypsin_dom	PRSS53 PRSS12 CELA2A CELA2B	1.29e-03	121	73	4	IPR001254
Domain	TIL_dom	FCGBP VWF	1.33e-03	14	73	2	IPR002919
Domain	Peptidase_S1_PA	PRSS53 PRSS12 CELA2A CELA2B	1.37e-03	123	73	4	IPR009003
Domain	CUB_dom	ADGRB3 DMBT1 SEZ6L	1.44e-03	57	73	3	IPR000859
Domain	VWD	FCGBP VWF	1.75e-03	16	73	2	SM00216
Domain	VWF_type-D	FCGBP VWF	1.75e-03	16	73	2	IPR001846
Domain	VWFD	FCGBP VWF	1.75e-03	16	73	2	PS51233
Domain	VWD	FCGBP VWF	1.75e-03	16	73	2	PF00094
Domain	AMP-bd_C	ACSM3 ACSM1	1.97e-03	17	73	2	IPR025110
Domain	AMP-binding_C	ACSM3 ACSM1	1.97e-03	17	73	2	PF13193
Domain	F-box	FBXW2 SKP2 FBXL5	2.29e-03	67	73	3	PF00646
Domain	VWC_out	FCGBP VWF	2.47e-03	19	73	2	SM00215
Domain	Leu-rich_rpt_Cys-con_subtyp	SKP2 FBXL5	2.47e-03	19	73	2	IPR006553
Domain	LRR_CC	SKP2 FBXL5	2.47e-03	19	73	2	SM00367
Domain	FBOX	FBXW2 SKP2 FBXL5	2.82e-03	72	73	3	PS50181
Domain	F-box_dom	FBXW2 SKP2 FBXL5	3.16e-03	75	73	3	IPR001810
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS12 THSD4 SEMA5B ADAMTS9 SPON1 ADAMTS20 ADAMTS8 ADAMTSL3	4.23e-12	39	61	8	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS12 THSD4 SEMA5B ADAMTS9 SPON1 ADAMTS20 ADAMTS8 ADAMTSL3	4.23e-12	39	61	8	MM15165
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTS12 THSD4 SEMA5B ADAMTS9 SPON1 ADAMTS20 ADAMTS8 ADAMTSL3	4.61e-10	68	61	8	M27303
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS12 THSD4 SEMA5B ADAMTS9 SPON1 ADAMTS20 ADAMTS8 ADAMTSL3	2.07e-08	109	61	8	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS12 THSD4 SEMA5B ADAMTS9 SPON1 ADAMTS20 ADAMTS8 ADAMTSL3	2.38e-08	111	61	8	M27416
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	ADAMTS12 THSD4 SEMA5B ADAMTS9 SPON1 ADAMTS20 ADAMTS8 ADAMTSL3	1.72e-07	143	61	8	M27275
Pathway	REACTOME_DISEASES_OF_METABOLISM	ADAMTS12 THSD4 SEMA5B ADAMTS9 SPON1 ADAMTS20 ADAMTS8 LCT ADAMTSL3	1.17e-06	250	61	9	M27554
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	ADAMTS12 THSD4 QSOX1 TRIM25 SEMA5B ADAMTS9 SPON1 ADAMTS20 WSB2 FBXW2 ADAMTS8 HERC2 ADAMTSL3 SKP2 FBXL5 TTLL7 SEC13	1.19e-04	1475	61	17	M19806
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	ADAMTS12 THSD4 QSOX1 SEMA5B ADAMTS9 SPON1 ADAMTS20 WSB2 FBXW2 ADAMTS8 HERC2 ADAMTSL3 SKP2 FBXL5 TTLL7 SEC13	2.01e-04	1389	61	16	MM15307
Pathway	BIOCARTA_PEPI_PATHWAY	CELA2A CELA2B	3.81e-04	7	61	2	MM1589
Pathway	KEGG_MEDICUS_REFERENCE_COMMON_PATHWAY_OF_COMPLEMENT_CASCADE_MAC_FORMATION	C6 C8A	3.81e-04	7	61	2	M47873
Pathway	BIOCARTA_PEPI_PATHWAY	CELA2A CELA2B	5.07e-04	8	61	2	M22084
Pathway	REACTOME_TERMINAL_PATHWAY_OF_COMPLEMENT	C6 C8A	5.07e-04	8	61	2	M27006
Pathway	REACTOME_TERMINAL_PATHWAY_OF_COMPLEMENT	C6 C8A	5.07e-04	8	61	2	MM14656
Pathway	BIOCARTA_ALTERNATIVE_PATHWAY	C6 C8A	6.50e-04	9	61	2	M22072
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_MAC_INHIBITION	C6 C8A	6.50e-04	9	61	2	M47881
Pathway	WP_COMPLEMENTMEDIATED_INFLAMMATION_OF_PULMONARY_ALVEOLUS_IN_COVID19_HYPOTHETICAL_PATHWAY	C6 C8A	1.18e-03	12	61	2	M48316
Pathway	BIOCARTA_LECTIN_PATHWAY	C6 C8A	1.39e-03	13	61	2	M4732
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS12 THSD4 UNC5A SEMA5B ADAMTS9 SPON1 ISM1 ADGRB1 ADGRB3 ADAMTS20 PAPLN ADAMTS8 C6 ADAMTSL3	8.03e-24	75	76	14	20637190
Pubmed	Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ.	ADAMTS9 SPON1 XBP1 ADAMTS20	6.87e-09	11	76	4	33909046
Pubmed	Polyubiquitination of the B-cell translocation gene 1 and 2 proteins is promoted by the SCF ubiquitin ligase complex containing βTrCP.	FBXW2 SKP2 FBXL5	1.63e-06	11	76	3	22975506
Pubmed	Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.	ADAMTS12 ADAMTS9 ADAMTS20	2.17e-06	12	76	3	25770910
Pubmed	Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.	ASAH2 ASAH2B	4.71e-06	2	76	2	10652340
Pubmed	Neutral ceramidase gene: role in regulating ceramide-induced apoptosis.	ASAH2 ASAH2B	4.71e-06	2	76	2	14557071
Pubmed	Genomic structure and promoter analysis of the mouse neutral ceramidase gene.	ASAH2 ASAH2B	4.71e-06	2	76	2	12435403
Pubmed	A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms.	THSD4 PAPLN	4.71e-06	2	76	2	19734141
Pubmed	Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney.	ASAH2 ASAH2B	4.71e-06	2	76	2	11328816
Pubmed	Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection.	ASAH2 ASAH2B	4.71e-06	2	76	2	35354041
Pubmed	Hepatitis B virus-induced hFGL2 transcription is dependent on c-Ets-2 and MAPK signal pathway.	ETS2 FGL2	4.71e-06	2	76	2	18801734
Pubmed	Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu.	ASAH2 ASAH2B	4.71e-06	2	76	2	16126722
Pubmed	Elastase-2, a Tissue Alternative Pathway for Angiotensin II Generation, Plays a Role in Circulatory Sympathovagal Balance in Mice.	CELA2A CELA2B	4.71e-06	2	76	2	28386233
Pubmed	Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation.	ASAH2 ASAH2B	4.71e-06	2	76	2	19345744
Pubmed	Lactosylceramide contributes to mitochondrial dysfunction in diabetes.	ASAH2 ASAH2B	4.71e-06	2	76	2	26900161
Pubmed	Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans.	CELA2A CELA2B	4.71e-06	2	76	2	16327289
Pubmed	Two medium-chain acyl-coenzyme A synthetase genes, SAH and MACS1, are associated with plasma high-density lipoprotein cholesterol levels, but they are not associated with essential hypertension.	ACSM3 ACSM1	4.71e-06	2	76	2	15361761
Pubmed	Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.	ASAH2 ASAH2B	4.71e-06	2	76	2	22940715
Pubmed	Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.	ASAH2 ASAH2B	4.71e-06	2	76	2	24659784
Pubmed	A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease.	ASAH2 ASAH2B	4.71e-06	2	76	2	17334805
Pubmed	Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death.	ASAH2 ASAH2B	4.71e-06	2	76	2	26747710
Pubmed	Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product.	ACSM3 ACSM1	4.71e-06	2	76	2	11470804
Pubmed	Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA.	ASAH2 ASAH2B	4.71e-06	2	76	2	21613224
Pubmed	Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1.	ADAMTS9 ADAMTS20	4.71e-06	2	76	2	12514189
Pubmed	Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases.	ASAH2 ASAH2B	4.71e-06	2	76	2	10753931
Pubmed	Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.	CELA2A CELA2B	4.71e-06	2	76	2	3646943
Pubmed	Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients.	PAPLN IFNLR1	4.71e-06	2	76	2	19724244
Pubmed	Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids.	ASAH2 ASAH2B	4.71e-06	2	76	2	16380386
Pubmed	Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury.	ASAH2 ASAH2B	4.71e-06	2	76	2	35151662
Pubmed	Identification of genetic drivers of plasma lipoprotein size in the Diversity Outbred mouse population.	ASAH2 ASAH2B	4.71e-06	2	76	2	37944753
Pubmed	Role of neutral ceramidase in colon cancer.	ASAH2 ASAH2B	4.71e-06	2	76	2	27609772
Pubmed	ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.	ADAMTS9 ADAMTS20 ADAMTS8	1.11e-05	20	76	3	19922873
Pubmed	Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.	ADAMTS9 SPON1 ADAMTS20 ADAMTS8	1.21e-05	64	76	4	22261194
Pubmed	The molecular circuitry regulating the switch between iron deficiency and overload in mice.	ASAH2 ASAH2B	1.41e-05	3	76	2	16418170
Pubmed	Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages.	ASAH2 ASAH2B	1.41e-05	3	76	2	38302493
Pubmed	Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85α.	TRIM25 XBP1	1.41e-05	3	76	2	35871160
Pubmed	A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression.	ADAMTS9 ADAMTS20	1.41e-05	3	76	2	24753090
Pubmed	Identification of a functional hepatocyte nuclear factor 4 binding site in the neutral ceramidase promoter.	ASAH2 ASAH2B	1.41e-05	3	76	2	20803549
Pubmed	Expression of intestinal and lung alkaline sphingomyelinase and neutral ceramidase in cystic fibrosis f508del transgenic mice.	ASAH2 ASAH2B	1.41e-05	3	76	2	18955860
Pubmed	Neutral ceramidase secreted by endothelial cells is released in part associated with caveolin-1.	ASAH2 ASAH2B	1.41e-05	3	76	2	12921776
Pubmed	Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).	ADGRB1 ADGRB3	1.41e-05	3	76	2	9533023
Pubmed	Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma.	ADGRB1 ADGRB3	1.41e-05	3	76	2	15225653
Pubmed	Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA.	CELA2A CELA2B	1.41e-05	3	76	2	3427074
Pubmed	Degradomic Identification of Membrane Type 1-Matrix Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate.	ADAMTS9 ADAMTS20	1.41e-05	3	76	2	37169079
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	QSOX1 FCGBP C6 C8A MARCO FGL2	2.18e-05	257	76	6	16335952
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	THSD4 BBX ADGRB3 BACE2 MARCO IFNLR1	2.59e-05	265	76	6	19240061
Pubmed	Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.	ASAH2 ASAH2B	2.82e-05	4	76	2	33547170
Pubmed	Localization of neutral ceramidase in caveolin-enriched light membranes of murine endothelial cells.	ASAH2 ASAH2B	2.82e-05	4	76	2	11591392
Pubmed	The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.	C6 C8A	4.69e-05	5	76	2	10551839
Pubmed	FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation.	FBXW2 SKP2	4.69e-05	5	76	2	30918250
Pubmed	ADAMTS9 and ADAMTS20 are differentially affected by loss of B3GLCT in mouse model of Peters plus syndrome.	ADAMTS9 ADAMTS20	4.69e-05	5	76	2	31600785
Pubmed	Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.	CELA2A CELA2B	4.69e-05	5	76	2	20179351
Pubmed	The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor.	FBXW2 SKP2	4.69e-05	5	76	2	28090088
Pubmed	Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.	C6 C8A	7.03e-05	6	76	2	22832194
Pubmed	Genetic differences between five European populations.	HERC2 LCT	7.03e-05	6	76	2	20616560
Pubmed	HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.	HERC2 FBXL5	7.03e-05	6	76	2	24778179
Pubmed	Identification of a family of human F-box proteins.	FBXW2 SKP2 FBXL5	7.39e-05	37	76	3	10531035
Pubmed	The DNA-binding activity of transcription factor PTF1 parallels the synthesis of pancreas-specific mRNAs during mouse development.	CELA2A CELA2B	9.83e-05	7	76	2	2294404
Pubmed	ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.	XBP1 IFNLR1	9.83e-05	7	76	2	30254094
Pubmed	Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10.	FBXW2 SKP2	9.83e-05	7	76	2	11735228
Pubmed	Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes.	CELA2A CELA2B	9.83e-05	7	76	2	3641189
Pubmed	CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.	C6 C8A	9.83e-05	7	76	2	30552328
Pubmed	Netrin 1 and Dcc signalling are required for confinement of central axons within the central nervous system.	UNC5A ROBO3	9.83e-05	7	76	2	24449837
Pubmed	Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk.	SPON1 DMBT1	9.83e-05	7	76	2	17525270
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	VWF ADAMTS9 TAF1C ZNF197 ADGRB3 ETS2 ADAMTS8 HERC2 BACE2 GPRASP2 SEZ6L	1.06e-04	1285	76	11	35914814
Pubmed	NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation.	CELA2A XBP1 CELA2B	1.08e-04	42	76	3	37353485
Pubmed	Molecular characterization of a novel human gene, SEC13R, related to the yeast secretory pathway gene SEC13, and mapping to a conserved linkage group on human chromosome 3p24-p25 and mouse chromosome 6.	VWF SEC13	1.31e-04	8	76	2	7987303
Pubmed	Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation.	ADAMTS9 ADAMTS20	1.31e-04	8	76	2	21041365
Pubmed	The secreted metalloprotease ADAMTS20 is required for melanoblast survival.	ADAMTS9 ADAMTS20	1.31e-04	8	76	2	18454205
Pubmed	Molecular organization and function of the complement system.	C6 C8A	1.31e-04	8	76	2	3052276
Pubmed	Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.	NRXN3 ADGRB1 ADGRB3	2.05e-04	52	76	3	24613359
Pubmed	ADAMTS: a novel family of extracellular matrix proteases.	ADAMTS12 ADAMTS9	2.10e-04	10	76	2	11167130
Pubmed	Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.	FBXW2 SKP2 FBXL5	2.42e-04	55	76	3	37028429
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	ADAMTS12 THSD4 QSOX1 PRSS53 SEMA5B PAPLN BACE2 KAT14 SEZ6L	2.95e-04	985	76	9	12975309
Pubmed	Characterization of the Cullin7 E3 ubiquitin ligase--heterodimerization of cullin substrate receptors as a novel mechanism to regulate cullin E3 ligase activity.	FBXW2 SKP2	3.07e-04	12	76	2	21946088
Pubmed	Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.	ETS2 BACE2	3.07e-04	12	76	2	27100087
Pubmed	Systematic analysis and nomenclature of mammalian F-box proteins.	FBXW2 SKP2 FBXL5	3.29e-04	61	76	3	15520277
Pubmed	The E3 ligase subunit FBXO45 binds the interferon-λ receptor and promotes its degradation during influenza virus infection.	TRIM25 IFNLR1	3.62e-04	13	76	2	36379255
Pubmed	The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family.	ADGRB1 ADGRB3	3.62e-04	13	76	2	21930703
Pubmed	Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2.	ETS2 ETV2	3.62e-04	13	76	2	25802403
Pubmed	Single-nucleus RNA sequencing of developing superior colliculus identifies neuronal diversity and candidate mediators of circuit assembly.	SPON1 ROBO3	3.62e-04	13	76	2	37624694
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	GMNC CTTNBP2 TRIM25 BBX KLHL30 ADGRB1 XBP1 ALPK1 KAT14 IFNLR1	3.65e-04	1242	76	10	30973865
Pubmed	F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression.	FBXW2 SKP2	4.22e-04	14	76	2	26087183
Pubmed	The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.	TRIM25 HERC2	4.22e-04	14	76	2	27626314
Pubmed	Parallel ascending spinal pathways for affective touch and pain.	MRGPRX2 ROBO3	4.22e-04	14	76	2	33116307
Pubmed	CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression.	SPON1 ISM1 GPR52 FGL2	4.59e-04	163	76	4	23333304
Pubmed	Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development.	CELA2A CELA2B	4.86e-04	15	76	2	24793170
Pubmed	Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage.	MPZ VWF	4.86e-04	15	76	2	20457761
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	VWF SPON1 PAPLN DMBT1	5.03e-04	167	76	4	22159717
Pubmed	The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas.	CELA2A CELA2B	5.54e-04	16	76	2	9851981
Pubmed	Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells.	CELA2A CELA2B	5.54e-04	16	76	2	19635472
Pubmed	Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation.	ETS2 ETV2	5.54e-04	16	76	2	24727028
Pubmed	Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord.	UNC5A ROBO3	5.54e-04	16	76	2	28434801
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	VWF CELA2A CELA2B DMBT1	5.99e-04	175	76	4	28071719
Pubmed	Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.	FBXW2 SKP2	6.27e-04	17	76	2	19398581
Pubmed	ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family.	MPZ ETS2	6.27e-04	17	76	2	10464288
Pubmed	Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus.	ROBO3 LCT	6.27e-04	17	76	2	33084572
Pubmed	Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation.	ADAMTS9 ADAMTS20	6.27e-04	17	76	2	22183742
Pubmed	M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.	FBXW2 SKP2	7.05e-04	18	76	2	15070733
Pubmed	TRIB3‒GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target.	TRIM25 HERC2	7.05e-04	18	76	2	34729304
Cytoband	5p13	C6 SKP2	3.62e-04	17	76	2	5p13
Cytoband	1q24	QSOX1 GPR52	5.04e-04	20	76	2	1q24
Cytoband	22q12.1	XBP1 SEZ6L	1.30e-03	32	76	2	22q12.1
Cytoband	Ensembl 112 genes in cytogenetic band chr5p13	ADAMTS12 C6 SKP2	1.62e-03	139	76	3	chr5p13
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS12 ADAMTS9 ADAMTS20 ADAMTS8	2.47e-07	19	53	4	50
GeneFamily	ADAMTS like	THSD4 PAPLN ADAMTSL3	8.26e-07	7	53	3	947
GeneFamily	Adhesion G protein-coupled receptors, subfamily B	ADGRB1 ADGRB3	2.52e-05	3	53	2	912
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	UNC5A PAPLN ROBO3 ADAMTSL3	1.26e-03	161	53	4	593
GeneFamily	F-box and leucine rich repeat proteins	SKP2 FBXL5	1.71e-03	21	53	2	558
GeneFamily	Acyl-CoA synthetase family	ACSM3 ACSM1	2.62e-03	26	53	2	40
GeneFamily	ETS transcription factor family	ETS2 ETV2	3.04e-03	28	53	2	534
GeneFamily	Complement system\|Sushi domain containing	C6 C8A	4.98e-03	36	53	2	492
Coexpression	NABA_MATRISOME	ADAMTS12 THSD4 VWF SEMA5B ADAMTS9 PRSS12 SPON1 CELA2A ISM1 ADAMTS20 PAPLN ADAMTS8 CELA2B DMBT1 ADAMTSL3 FGL2	2.06e-08	1008	75	16	MM17056
Coexpression	NABA_MATRISOME	ADAMTS12 THSD4 VWF SEMA5B ADAMTS9 PRSS12 SPON1 CELA2A ISM1 ADAMTS20 PAPLN ADAMTS8 CELA2B DMBT1 ADAMTSL3 FGL2	2.64e-08	1026	75	16	M5889
Coexpression	NABA_ECM_REGULATORS	ADAMTS12 ADAMTS9 PRSS12 CELA2A ADAMTS20 ADAMTS8 CELA2B ADAMTSL3	4.10e-07	238	75	8	M3468
Coexpression	NABA_ECM_REGULATORS	ADAMTS12 ADAMTS9 PRSS12 CELA2A ADAMTS20 ADAMTS8 CELA2B ADAMTSL3	4.66e-07	242	75	8	MM17062
Coexpression	INAMURA_LUNG_CANCER_SCC_DN	VWF ADAMTS8 ADAMTSL3	6.30e-06	13	75	3	M1255
Coexpression	NABA_ECM_GLYCOPROTEINS	THSD4 VWF SPON1 PAPLN DMBT1 FGL2	1.84e-05	191	75	6	MM17059
Coexpression	NABA_ECM_GLYCOPROTEINS	THSD4 VWF SPON1 PAPLN DMBT1 FGL2	2.12e-05	196	75	6	M3008
Coexpression	NABA_MATRISOME_ASSOCIATED	ADAMTS12 SEMA5B ADAMTS9 PRSS12 CELA2A ISM1 ADAMTS20 ADAMTS8 CELA2B ADAMTSL3	4.69e-05	738	75	10	MM17058
Coexpression	NABA_MATRISOME_ASSOCIATED	ADAMTS12 SEMA5B ADAMTS9 PRSS12 CELA2A ISM1 ADAMTS20 ADAMTS8 CELA2B ADAMTSL3	5.42e-05	751	75	10	M5885
Coexpression	NABA_MATRISOME_HYPERPLASTIC_PANCREATIC_ISLETS	CELA2A CELA2B DMBT1	5.58e-05	26	75	3	MM17051
Coexpression	CAIRO_HEPATOBLASTOMA_DN	IL13RA2 ETS2 C6 C8A ENO3 MARCO	1.18e-04	267	75	6	M13449
Coexpression	NABA_CORE_MATRISOME	THSD4 VWF SPON1 PAPLN DMBT1 FGL2	1.26e-04	270	75	6	MM17057
Coexpression	DESCARTES_FETAL_PLACENTA_SMOOTH_MUSCLE_CELLS	SEMA5B ADGRB1 ADAMTS20 ADAMTSL3	1.26e-04	89	75	4	M40280
Coexpression	GSE24671_CTRL_VS_BAKIMULC_INFECTED_MOUSE_SPLENOCYTES_DN	ADAMTS12 THSD4 ISM1 ETS2 FGL2	1.29e-04	170	75	5	M9445
Coexpression	NABA_CORE_MATRISOME	THSD4 VWF SPON1 PAPLN DMBT1 FGL2	1.39e-04	275	75	6	M5884
CoexpressionAtlas	DevelopingLowerUrinaryTract_adult_bladder_emap-29457_k-means-cluster#3_top-relative-expression-ranked_1000	CPEB2 MPZ KLHL30 ASAH2 SPON1 IRAG1 TTLL7 FGL2	7.12e-07	208	75	8	gudmap_developingLowerUrinaryTract_adult_bladder_1000_k3
CoexpressionAtlas	DevelopingLowerUrinaryTract_P1_bladder_J_emap-30374_k-means-cluster#1_top-relative-expression-ranked_1000	CPEB2 KLHL30 ASAH2 DYNLT3 IRAG1 TTLL7 FGL2	9.68e-07	149	75	7	gudmap_developingLowerUrinaryTract_P1_bladder_J_1000_k1
CoexpressionAtlas	DevelopingLowerUrinaryTract_adult_bladder_emap-29457_top-relative-expression-ranked_1000	CPEB2 MPZ VWF KLHL30 ASAH2 SPON1 IRAG1 BACE2 ADAMTSL3 TTLL7 FGL2	5.10e-05	734	75	11	gudmap_developingLowerUrinaryTract_adult_bladder_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_P2_bladder detrusor (LCM)_emap-30376_top-relative-expression-ranked_1000	CPEB2 IL13RA2 KLHL30 DYNLT3 FBXW2 ADAMTS8 IRAG1 LCT ADAMTSL3 ENO3 TTLL7	7.06e-05	761	75	11	gudmap_developingLowerUrinaryTract_P2_bladder detrusor (LCM)_1000
ToppCell	facs-Lung-Endomucin-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 NRXN3 VWF SEMA5B BACE2 ADAMTSL3 FGL2	2.34e-08	178	76	7	5cc182e6faa7ba5b88378d2c953be29bbbb95a7e
ToppCell	facs-Lung-Endomucin-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 NRXN3 VWF SEMA5B BACE2 ADAMTSL3 FGL2	2.34e-08	178	76	7	f9a16bc3f09c35c7d30e3809da024bc2dcf746ed
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ACSM3 VWF ADAMTS9 ACSM1 ADGRB3 KIAA1755 ADAMTSL3	2.73e-08	182	76	7	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC5A QSOX1 FCGBP ETV2 SLC12A8 C8A BACE2	2.83e-08	183	76	7	5a936fb07074cec753bf19e3e3e52499605ea22c
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC5A QSOX1 FCGBP ETV2 SLC12A8 C8A BACE2	2.83e-08	183	76	7	07c18ccc45ddc9c22e482bd9ffb87f46ebcfe473
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	THSD4 SEMA5B SPON1 ISM1 ADAMTS8 IRAG1 ADAMTSL3	4.08e-08	193	76	7	000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCell	Goblet\|World / Class top	QSOX1 XBP1 SLC12A8 DMBT1 BACE2 FGL2	2.93e-07	157	76	6	b352aa37d662629db6a9c6def9ee6d7c49a9071c
ToppCell	Goblet-gob-1\|World / Class top	QSOX1 XBP1 SLC12A8 DMBT1 BACE2 FGL2	3.16e-07	159	76	6	62d4ca2b538382419252e306d7a789b64420fb18
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Col23a1_Adamts2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	UNC5A SEMA5B PRSS12 SPON1 GPR52 ROBO3	4.36e-07	168	76	6	3fe432267656aff81b6d92c18d1b6fc0cde73d6a
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS12 SEMA5B ADAMTS9 PRSS12 ROBO3 ADAMTSL3	4.52e-07	169	76	6	bddb28a8b9afbe4a68f082e82caf96a6666fc674
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS12 SEMA5B ADAMTS9 PRSS12 ROBO3 ADAMTSL3	4.52e-07	169	76	6	5ce46bac8e767feec7ecdc61689de225c49bd3f7
ToppCell	metastatic_Brain-Endothelial_cells-Stalk-like_ECs\|Endothelial_cells / Location, Cell class and cell subclass	MPZ PRSS12 ETV2 PAPLN ROBO3 TTLL7	5.54e-07	175	76	6	f6a6db992e803d36c866a91706b02f67e0fd3e09
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SEMA5B PRSS12 SPON1 GPR52 ROBO3 BACE2	5.54e-07	175	76	6	c227fc5d1ccb69b82a96a6354913cafaf27d0eec
ToppCell	COVID-19-Heart-Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADAMTS12 SEMA5B ADAMTS9 ADGRB3 IRAG1 ADAMTSL3	6.75e-07	181	76	6	33cac65ed1ea5e7bd72250495df4f850b143d5aa
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-nan\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 FCGBP CELA2A SLC12A8 BACE2 ENO3	6.75e-07	181	76	6	75340f0c06977c88f9d2e56265f4aa84d706d2c6
ToppCell	COVID-19-Heart-EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADAMTS12 VWF ADAMTS9 ADGRB3 IRAG1 ADAMTSL3	6.97e-07	182	76	6	e67f3234165199085c793915ebb1f9bbd845e933
ToppCell	LA-07._Pericyte\|World / Chamber and Cluster_Paper	ADAMTS12 SEMA5B ADAMTS9 ADGRB3 IRAG1 ADAMTSL3	7.20e-07	183	76	6	e3835db4795362b0442d5893baf2a78efcc20428
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 THSD4 PRSS12 ISM1 IRAG1 ADAMTSL3	7.20e-07	183	76	6	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	COVID-19-Heart-Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	ADAMTS12 SEMA5B ADAMTS9 ADGRB3 IRAG1 ADAMTSL3	7.43e-07	184	76	6	21790cdfa3b4036ad413fd44b94e31563116f25f
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 THSD4 ACSM3 PRSS12 ISM1 IRAG1	7.67e-07	185	76	6	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	COVID-19-Neuronal_cells-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	THSD4 UNC5A NRXN3 ADAMTS9 BACE2 ADAMTSL3	7.67e-07	185	76	6	4a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 THSD4 PRSS12 ISM1 IRAG1 ADAMTSL3	7.67e-07	185	76	6	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	LA-07._Pericyte\|LA / Chamber and Cluster_Paper	ADAMTS12 SEMA5B ADAMTS9 ADGRB3 IRAG1 ADAMTSL3	7.67e-07	185	76	6	ba5baa4d7f097108622674de5b7f4fd279843d24
ToppCell	COVID-19-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	THSD4 UNC5A NRXN3 ADAMTS9 BACE2 ADAMTSL3	7.67e-07	185	76	6	36ce23893915f5c380cca39b2c33a516edf31c3a
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	ADAMTS12 SEMA5B ADAMTS9 ADGRB3 IRAG1 ADAMTSL3	7.92e-07	186	76	6	cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCell	Pericytes-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	ADAMTS12 SEMA5B ISM1 KIAA1755 ADAMTS8 IRAG1	8.17e-07	187	76	6	35f25780d113f60bf4c13749013c09612ee4ff41
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	THSD4 SPON1 ISM1 ADGRB3 ADAMTS8 IRAG1	8.43e-07	188	76	6	4d1e5f85342ae550086609d7680e32730b78b5d2
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	ADAMTS12 SEMA5B ADAMTS9 ADGRB3 IRAG1 ADAMTSL3	9.24e-07	191	76	6	78c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	ACSM3 VWF SPON1 ADGRB3 KIAA1755 ADAMTSL3	9.53e-07	192	76	6	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS12 THSD4 SEMA5B SPON1 IRAG1 SEZ6L	9.82e-07	193	76	6	469a7f1c2ff7137cc5a064464456911f67f92e70
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA5B DGKK ADAMTSL3 MARCO SEZ6L	5.51e-06	148	76	5	dfd3f2c4b884ea9e23831a242a89ac985b409640
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MPZ NRXN3 ADGRB3 KIAA1755 SEZ6L	6.69e-06	154	76	5	30cb4bb297fa815adb829f3b5cafca56fcbcb810
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MPZ NRXN3 ADGRB3 KIAA1755 SEZ6L	6.69e-06	154	76	5	ade094e2947761a0a34daa8fcff3e9ea8437e4a5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MPZ NRXN3 ADGRB3 KIAA1755 SEZ6L	6.69e-06	154	76	5	42bd8f88fd075a2d4edde394785decad88a2660a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MPZ NRXN3 ADGRB3 KIAA1755 SEZ6L	6.69e-06	154	76	5	6425d9861148586466febd6eceae1b1f9b9a14c1
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2-Exc_L5_FEZF2_DYRK2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS12 SEMA5B SPON1 ROBO3 ENO3	8.05e-06	160	76	5	e2504c6deba4949a3a716a9ca68755f787bc0ae0
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3\|Striatum / BrainAtlas - Mouse McCarroll V32	THSD4 KLHL30 ADAMTS8 IRAG1 FGL2	9.07e-06	164	76	5	e24b06a14565f7798ac50c2fe3f34d4547b9000e
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2-Exc_L5-6_FEZF2_CYP26B1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS12 SEMA5B SPON1 ROBO3 ENO3	9.07e-06	164	76	5	902cfdb8155bb2773aa69826d5b3b810a39c8d34
ToppCell	LV-16._Neuronal\|World / Chamber and Cluster_Paper	MPZ NRXN3 ADGRB3 ADAMTS8 C8A	9.35e-06	165	76	5	6ed52cb756d21addf46c7f6c457458b01339fe04
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS12 SEMA5B SPON1 ROBO3 ENO3	9.62e-06	166	76	5	01544c851588f1cde05d6700c3d1167f70a0fbd5
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS12 SEMA5B SPON1 ROBO3 ENO3	9.62e-06	166	76	5	c22a97353f7eb084f768c13d7767a80b30f05043
ToppCell	Club-club-2\|World / Class top	ADAMTS12 QSOX1 FCGBP ACSM1 DMBT1	9.62e-06	166	76	5	56f11efb6b686b3ee2c34a051f626e3d761b5112
ToppCell	Ciliated_cells-B-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	IL13RA2 PRSS12 ACSM1 ADAMTS8 C6	9.62e-06	166	76	5	4b1056aad8a99827835242b8ab0c7f2bb84471f1
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GMNC FCGBP NRXN3 XBP1 BACE2	1.05e-05	169	76	5	db73dae011ff3749b3706e50ab46d03b775dd6bb
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GMNC FCGBP NRXN3 XBP1 BACE2	1.05e-05	169	76	5	97b7047b87ce0052d8580565c9b44fd2aa6f0d5c
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GMNC FCGBP NRXN3 XBP1 BACE2	1.05e-05	169	76	5	1a684471dbda42e1470e5a889648666e14f25982
ToppCell	LV-16._Neuronal\|LV / Chamber and Cluster_Paper	MPZ NRXN3 ADGRB3 ADAMTS8 C8A	1.05e-05	169	76	5	a8fc8ab0f0757e939e213efb61c03cfe390bf7d2
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2-Exc_L5-6_FEZF2_RSAD2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS12 SEMA5B SPON1 ROBO3 ENO3	1.08e-05	170	76	5	63dfbc4746717132dc81b6bac868c7498fc96283
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Penk_Col27a1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SEMA5B SPON1 GPR52 ROBO3 BACE2	1.11e-05	171	76	5	d07e2c5f7d7f12c68860d4161d76372de174f1d8
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SEMA5B ADAMTS9 KLHL30 ADGRB3 IRAG1	1.21e-05	174	76	5	015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2-Exc_L5-6_FEZF2_MYBPHL\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS12 SEMA5B PRSS12 ROBO3 ADAMTSL3	1.24e-05	175	76	5	bc6bd8c3ce956245ef4db91af9501649d5c09478
ToppCell	(03)_Secretory\|World / shred by cell type and Timepoint	QSOX1 FCGBP ACSM1 XBP1 DMBT1	1.28e-05	176	76	5	cb7b1945788196ca79007f0768b6576ec885a0e5
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CTTNBP2 ISM1 ADGRB3 ADAMTS8 IRAG1	1.31e-05	177	76	5	b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS12 THSD4 SEMA5B SPON1 SLC12A8	1.31e-05	177	76	5	4553ee8cd9c24db6511b09fe49ed11a89e7cde9e
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 FCGBP CELA2A SLC12A8 BACE2	1.35e-05	178	76	5	07d6d5275a4d17f8024fde74e92ab2505b4adfbf
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 THSD4 PRSS12 ISM1 IRAG1	1.39e-05	179	76	5	02c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	THSD4 SPON1 ISM1 ADGRB3 IRAG1	1.46e-05	181	76	5	25915e2500430a902db37d79a749ce2990b69810
ToppCell	RA-07._Pericyte\|RA / Chamber and Cluster_Paper	ADAMTS12 SEMA5B ADAMTS9 ADGRB3 IRAG1	1.46e-05	181	76	5	8dfb42d096db6c2df9b41303a7199d134d4bff07
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CTTNBP2 SPON1 KIAA1755 PAPLN IRAG1	1.46e-05	181	76	5	b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCell	Pericytes-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	ADAMTS12 CTTNBP2 SEMA5B ADAMTS8 IRAG1	1.46e-05	181	76	5	ff445a8e56522e57e27405184d123cf905caf8cc
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 THSD4 SPON1 IRAG1 ADAMTSL3	1.50e-05	182	76	5	44764676ed3f51ba171ce63f669390392fa50a43
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAMTS9 SPON1 ISM1 ADGRB3 ETS2	1.50e-05	182	76	5	ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	UNC5A QSOX1 FCGBP XBP1 BACE2	1.50e-05	182	76	5	94e70746e35a3062015d4b83ee545f4f84f47420
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 THSD4 SPON1 IRAG1 ADAMTSL3	1.50e-05	182	76	5	d82f59a3f930a840dde27dc6ab024f227a26d446
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 VWF SPON1 BACE2 GPRASP2	1.54e-05	183	76	5	6c4a09c02e30e1f24dde39f8cb8c5b453826ee2e
ToppCell	droplet-Liver-Npc-21m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 PLB1 FCGBP ISM1 IFNLR1	1.54e-05	183	76	5	99ab7a43527eb226027efbcd8c0b6a8e46fc3c93
ToppCell	LV-07._Pericyte\|World / Chamber and Cluster_Paper	ADAMTS12 ADAMTS9 ADGRB3 IRAG1 ADAMTSL3	1.54e-05	183	76	5	273db6a3b00a93ca852498471187b642b5368185
ToppCell	droplet-Liver-Npc-21m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 PLB1 FCGBP ISM1 IFNLR1	1.54e-05	183	76	5	28916f0597690ff534578be2cb715b485cb1de1a
ToppCell	wk_20-22-Epithelial-PNS-intermediate_Schwann\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	MPZ NRXN3 ADAMTS9 KIAA1755 FGL2	1.58e-05	184	76	5	4e3ba64692868563a579902aa9c6f88cab5bce26
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 FCGBP CELA2A SLC12A8 BACE2	1.62e-05	185	76	5	e29079ef09aee62c3e9756341db4e59ca9dbf7ac
ToppCell	COVID-19-Heart-Fib_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ACSM3 ACSM1 ADGRB3 KIAA1755 ADAMTSL3	1.62e-05	185	76	5	8f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D231\|Adult / Lineage, Cell type, age group and donor	CTTNBP2 SPON1 ISM1 KIAA1755 ADAMTSL3	1.62e-05	185	76	5	fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCell	facs-Large_Intestine-Distal-24m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 FCGBP CELA2A SLC12A8 BACE2	1.62e-05	185	76	5	2ecc4b76b3645b65c226c2298bff307cc6479172
ToppCell	LV-07._Pericyte\|LV / Chamber and Cluster_Paper	ADAMTS12 ADAMTS9 ADGRB3 IRAG1 ADAMTSL3	1.62e-05	185	76	5	acb38eba871ec72f2a8136a33b87d33b8c85465d
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 FCGBP XBP1 SLC12A8 BACE2	1.67e-05	186	76	5	32d30f08b20a0a28e38b37bd52ab26d1d43736ce
ToppCell	RV-07._Pericyte\|RV / Chamber and Cluster_Paper	ADAMTS12 ADAMTS9 ADGRB3 IRAG1 ADAMTSL3	1.67e-05	186	76	5	c533b264fbe12bc35467486fc7fbde24ba968fe1
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	ADAMTS12 SPON1 ADGRB3 ADAMTS8 ADAMTSL3	1.71e-05	187	76	5	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	RV-07._Pericyte\|World / Chamber and Cluster_Paper	ADAMTS12 ADAMTS9 ADGRB3 IRAG1 ADAMTSL3	1.71e-05	187	76	5	dc274d6bbda619a2c914d84e2b4069cfef1739d1
ToppCell	droplet-Large_Intestine-COLON:P+D-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 ACSM3 FCGBP SLC12A8 BACE2	1.71e-05	187	76	5	a63fa3255ad58f3a73c596df99ce9649fdbaeb39
ToppCell	droplet-Large_Intestine-COLON:P+D\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 ACSM3 FCGBP SLC12A8 BACE2	1.71e-05	187	76	5	b1bb5c48258a9d058614d23001899dbe44857a1f
ToppCell	Control-Fibroblasts-Other_FB\|Control / group, cell type (main and fine annotations)	ADAMTS12 SPON1 ISM1 IRAG1 ADAMTSL3	1.71e-05	187	76	5	bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 ACSM3 FCGBP SLC12A8 BACE2	1.75e-05	188	76	5	bfd3b4f57785596b2bd2c657e0d2d8b0f40ba36d
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____podocyte-2\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPZ SPON1 KIAA1755 OPN5 IFNLR1	1.75e-05	188	76	5	c300accbac71a3bc075fe985543d8a8ead82531b
ToppCell	COVID-19-Heart-Fib_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ACSM3 ACSM1 ADGRB3 KIAA1755 ADAMTSL3	1.75e-05	188	76	5	fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell	facs-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPZ KLHL30 ADAMTS20 ADAMTS8 IRAG1	1.75e-05	188	76	5	794fc1d9a726945c42f7eac221eed938309b47a9
ToppCell	facs-Large_Intestine-Distal\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 FCGBP SLC12A8 BACE2 ENO3	1.85e-05	190	76	5	3964a8390522b61b73235151bb0a2ff36b856867
ToppCell	Mesenchymal-airway_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	SPON1 ISM1 ADGRB3 ADAMTS8 IRAG1	1.85e-05	190	76	5	645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS12 THSD4 SEMA5B SPON1 IRAG1	1.85e-05	190	76	5	7df63e5e0dd395676f4fc18cad0d8b2428390943
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS12 THSD4 SEMA5B SPON1 IRAG1	1.85e-05	190	76	5	140aca04c044cd7a93f81ff1631b00b5216d2cb1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 THSD4 SPON1 KIAA1755 IRAG1	1.89e-05	191	76	5	107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 THSD4 SPON1 KIAA1755 IRAG1	1.89e-05	191	76	5	bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADAMTS12 SPON1 ADGRB3 ADAMTS8 ADAMTSL3	1.89e-05	191	76	5	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	THSD4 SPON1 ISM1 ADGRB3 IRAG1	1.94e-05	192	76	5	72881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADAMTS12 SPON1 ADGRB3 ADAMTS8 ADAMTSL3	1.94e-05	192	76	5	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	COPD-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	ADAMTS12 QSOX1 SPON1 ADGRB3 ADAMTS8	1.94e-05	192	76	5	62904f94dfce430456f05066522cbf9bd29f4d7e
ToppCell	368C-Lymphocytic-NK_cells-Proliferating_NK_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FCGBP ZNF197 ETV2 ROBO3 ENO3	1.99e-05	193	76	5	5f5904cec8b2967154ef2eab3c48f51df53aca4a
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 FCGBP XBP1 SLC12A8 BACE2	1.99e-05	193	76	5	5a92697430f16c49e19a5f727d289d7bd1ece31c
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAMTS12 SPON1 ADGRB3 ADAMTS8 ADAMTSL3	1.99e-05	193	76	5	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 SPON1 ADGRB3 PSD3 ADAMTS8	1.99e-05	193	76	5	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-secretory_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 FCGBP XBP1 SLC12A8 BACE2	1.99e-05	193	76	5	64bcdbb422f8da6fc3275e82f6aaf562f546a180
Disease	cortical surface area measurement, neuroimaging measurement	THSD4 GMNC CTTNBP2 ADAMTS9 ADAMTS20 KIAA1755 SLC12A8	1.69e-06	227	74	7	EFO_0004346, EFO_0010736
Disease	4-hydroxyphenylacetylglutamine measurement	ACSM3 ACSM1	1.86e-05	3	74	2	EFO_0800688
Disease	brain measurement, neuroimaging measurement	THSD4 GMNC CTTNBP2 ADAMTS9 ADAMTS20 KIAA1755 SLC12A8 ADAMTS8	7.09e-05	550	74	8	EFO_0004346, EFO_0004464
Disease	indoleacetylglutamine measurement	ACSM3 ACSM1	9.25e-05	6	74	2	EFO_0800035
Disease	cortical thickness	THSD4 GMNC CTTNBP2 ADAMTS9 PRSS12 ADAMTS20 KIAA1755 SLC12A8 ADAMTS8 IRAG1 ADAMTSL3	9.92e-05	1113	74	11	EFO_0004840
Disease	underweight body mass index status	NRXN3 ADGRB3	2.21e-04	9	74	2	EFO_0005936
Disease	t-tau measurement	ADAMTS12 GMNC NRXN3 MARCO	2.89e-04	126	74	4	EFO_0004760
Disease	Bipolar I disorder	NRXN3 XBP1	3.36e-04	11	74	2	C0853193
Disease	brain connectivity measurement	THSD4 GMNC MPZ SPON1 ADAMTS20 ADAMTS8	5.09e-04	400	74	6	EFO_0005210
Disease	response to methotrexate, aspartate aminotransferase measurement	THSD4 PLB1	5.54e-04	14	74	2	EFO_0004736, GO_0031427
Disease	methylcobalamin deficiency type cblE, brain serotonin transporter measurement	VWF PSD3	7.28e-04	16	74	2	EFO_0004569, MONDO_0009354
Disease	urate measurement, bone density	THSD4 PLB1 ADGRB3 PSD3 ETS2 KIAA1755 DMBT1	9.23e-04	619	74	7	EFO_0003923, EFO_0004531
Disease	skin sensitivity to sun	ADAMTS12 HERC2	1.03e-03	19	74	2	EFO_0004795
Disease	Glioma	PSD3 XBP1 DMBT1	1.38e-03	87	74	3	C0017638
Disease	neuroimaging measurement	THSD4 GMNC CTTNBP2 PRSS12 ADAMTS20 KIAA1755 SLC12A8 ROBO3 IRAG1	1.39e-03	1069	74	9	EFO_0004346
Disease	glioblastoma (is_implicated_in)	ADGRB1 DMBT1	1.65e-03	24	74	2	DOID:3068 (is_implicated_in)
Disease	cerebrospinal fluid biomarker measurement	NRXN3 ASAH2 KIAA1755	1.83e-03	96	74	3	EFO_0006794
Disease	cortical surface area measurement	THSD4 GMNC CTTNBP2 ADAMTS9 PRSS12 ADAMTS20 KIAA1755 SLC12A8 IRAG1 ADAMTSL3	1.89e-03	1345	74	10	EFO_0010736
Disease	triglyceride measurement, alcohol consumption measurement	PLB1 PSD3 ASAH2B	2.12e-03	101	74	3	EFO_0004530, EFO_0007878
Disease	type 2 diabetes mellitus (implicated_via_orthology)	ADAMTS9 ADAMTS20 ADAMTS8	2.36e-03	105	74	3	DOID:9352 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FWTGSQLACWTNSET	BACE2	336	Q9Y5Z0
HEGCWNEESWTFSQS	BBX	651	Q8WY36
TQTEGAKADGSWSCW	C8A	531	P07357
AKADGSWSCWSSWSV	C8A	536	P07357
NEWSSWSACSASCSQ	ADGRB1	471	O14514
ESGVEEWSQWSTCSV	ADGRB3	291	O60242
EWSQWSTCSVTCGQG	ADGRB3	296	O60242
WSSWSQCSVTCSNGT	ADGRB3	406	O60242
WVLGDWSECSSTCGA	ADAMTS8	836	Q9UP79
ATSTSWQIVCNDASW	ASAH2B	86	P0C7U1
VDYATCSSSAWWGSS	CELA2A	181	P08217
SDWTVGNWSECSVSC	ADAMTS12	946	P58397
NCNEFSCPSWAASEW	ADAMTS20	1016	P59510
SWKANSWNECSVTCG	ADAMTS20	1476	P59510
SAWSNLSGFSSSASW	ALPK1	581	Q96QP1
SWSSVIGVWYSESTS	CRISP1	111	P54107
WQCTNGSEVQSSWAE	IL13RA2	111	Q14627
GSRSAWAVEFFASWC	QSOX1	56	O00391
GTKTDTWSTTQAWCF	KLHL30	336	Q0D2K2
SSDFWNLDWSSACSC	DGKK	476	Q5KSL6
WGTVCSSHWDDSDAS	PRSS12	191	P56730
SAWDSSDRSWASTVD	IFNLR1	381	Q8IU57
AQSFAWSSCSEWSIG	HERC2	771	O95714
CAVSGGSISSSNWWS	IGHV4-4	41	A0A075B6R2
STTEGAWEAPWCTVS	KIAA1755	596	Q5JYT7
ATSTSWQIVCNDASW	ASAH2	701	Q9NR71
WFAGCTNRTWNSSAV	ERVMER34-1	186	Q9H9K5
STCSAAQRDSWWSSG	IRAG1	881	Q9Y6F6
KSCQSFISWTGDGWE	ETS2	376	P15036
STWWSTVAGCLSVGS	KAT14	171	Q9H8E8
TSCTLDWWLAQASVG	OPN5	181	Q6U736
ALLSFSCWGSDWESD	LCT	11	P09848
SCWGSDWESDRNFIS	LCT	16	P09848
HGDIFEWCATSWLTS	GPR52	186	Q9Y2T5
EWCATSWLTSAYFTG	GPR52	191	Q9Y2T5
HDAAWSTGPWSSCSV	ADAMTS9	1441	Q9P2N4
SCCTTQLFASSWGWQ	ESPL1	1281	Q14674
WGSDSLQDSWCTAAG	CPEB2	221	Q7Z5Q1
VDYATCSSSGWWGST	CELA2B	181	P08218
GQWGCWSSWSTCDAT	C6	566	P13671
SDGWWSLEDVTCNNT	CTTNBP2	1026	Q8WZ74
GSEFWADGTCSQWCR	FCGBP	4421	Q9Y6R7
TESTLWSCTKNSWGH	MARCO	491	Q9UEW3
SSGWWFDACLSANLN	FGL2	376	Q14314
WDTTSDGTCTVRWEN	DYNLT3	86	P51808
FDQDDWATWTSFLSG	ENO3	296	P13929
TDISDSAFDSWSWLG	FBXL5	366	Q9UKA1
SAFDSWSWLGCCQSL	FBXL5	371	Q9UKA1
CTAWDSWSGASQTLG	ETV2	96	O00321
TGSFDNTVACWEWSS	FBXW2	201	Q9UKT8
GSWGTVCDDSWDTND	DMBT1	121	Q9UGM3
GSWGTVCDDSWDTND	DMBT1	621	Q9UGM3
GSWGTVCDDSWDTSD	DMBT1	881	Q9UGM3
QGSWGTVCDDSWDTN	DMBT1	1011	Q9UGM3
ASWEGQESCWNKQTS	SLC12A8	526	A0AV02
STDGEGDWSLWSVCS	ISM1	216	B1AKI9
QFSSIWWDDSGACRV	HSFX1	111	Q9UBD0
FIWTCDDASSNTWSP	SEC13	241	P55735
SNWSPWSACSSSTCD	SPON1	446	Q9HCB6
GSDTLTCQWDLSWSS	SEZ6L	781	Q9BYH1
VDVSTETWVSFWAAG	GMNC	31	A6NCL1
ASWTSQDTAGCSQWL	TAF1C	626	Q15572
WGCIVSSVWSSSNVA	NRXN3	26	Q9HDB5
WSGSEDEASNPFSFW	GPRASP2	281	Q96D09
AFWTTWTQSCSSNAL	XBP1	206	P17861
NWGSDFLCTEWKASN	PLB1	1066	Q6P1J6
DSGWCQTFDFITAAW	MRGPRX2	176	Q96LB1
DVSWCLSDSGWIVAT	ACSM1	261	Q08AH1
SDTGWAKSAWSSVFS	ACSM3	276	Q53FZ2
DLSSNVATSFTWGWD	SKP2	11	Q13309
VATSFTWGWDSSKTS	SKP2	16	Q13309
ASCWATGWDQDTSDA	PRSS53	156	Q2L4Q9
WGTSFQGSSSSVWET	ZNF197	26	O14709
TYAWSVENSSTDSWV	CD96	176	P40200
DFANSWALSSGEQWC	VWF	186	P04275
FSWSHGSWSDCSAEC	PAPLN	306	O95428
CVAKSSTGEATWSGW	ROBO3	521	Q96MS0
SASWCVEWFNTKISA	TRIM25	546	Q14258
FICNECGKSFTWWSS	ZNF775	281	Q96BV0
WSEWSKCTDDGAQSR	SEMA5B	971	Q9P283
EYWCQCVAWSSSGTT	UNC5A	121	Q6ZN44
FDWKSSCETWSVAFS	WSB2	21	Q9NYS7
SCETWSVAFSPDGSW	WSB2	26	Q9NYS7
TGKVEWFAGSWSQCS	THSD4	851	Q6ZMP0
WFAGSWSQCSIECGS	THSD4	856	Q6ZMP0
CNSSSLTENVWDESW	PSD3	351	Q9NYI0
GLWNCFCDSGSSWES	TTLL7	781	Q6ZT98
RWFTSVWSQCSVSCG	ADAMTSL3	1486	P82987
VTLHCSFWSSEWVSD	MPZ	46	P25189
SFWSSEWVSDDISFT	MPZ	51	P25189