Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium-dependent cysteine-type endopeptidase activity	CAPN8 CAPN1 CAPN2	2.17e-05	17	65	3	GO:0004198
GeneOntologyCellularComponent	calpain complex	CAPN1 CAPN2	5.87e-05	4	66	2	GO:0110158
HumanPheno	Short REM sleep	IQSEC2 RAI1	1.16e-04	4	23	2	HP:5200360
HumanPheno	Cerebellar gliosis	SLC25A46 LONP1	1.16e-04	4	23	2	HP:0012698
HumanPheno	Abnormal sleep architecture	IQSEC2 RAI1	1.16e-04	4	23	2	HP:5200298
HumanPheno	Onychotillomania	IQSEC2 RAI1	1.16e-04	4	23	2	HP:0032509
HumanPheno	Vocal cord polyp	IQSEC2 RAI1	1.16e-04	4	23	2	HP:0032041
Domain	Calpain_III	CAPN8 CAPN1 CAPN2	9.06e-06	12	66	3	IPR022683
Domain	calpain_III	CAPN8 CAPN1 CAPN2	9.06e-06	12	66	3	SM00720
Domain	C2_III	CAPN8 CAPN1 CAPN2	9.06e-06	12	66	3	IPR033883
Domain	Calpain_domain_III	CAPN8 CAPN1 CAPN2	1.18e-05	13	66	3	IPR022682
Domain	Calpain_III	CAPN8 CAPN1 CAPN2	1.18e-05	13	66	3	PF01067
Domain	Calpain_cysteine_protease	CAPN8 CAPN1 CAPN2	1.49e-05	14	66	3	IPR022684
Domain	CysPc	CAPN8 CAPN1 CAPN2	1.86e-05	15	66	3	SM00230
Domain	Peptidase_C2_calpain_cat	CAPN8 CAPN1 CAPN2	1.86e-05	15	66	3	IPR001300
Domain	Peptidase_C2	CAPN8 CAPN1 CAPN2	1.86e-05	15	66	3	PF00648
Domain	CALPAIN_CAT	CAPN8 CAPN1 CAPN2	1.86e-05	15	66	3	PS50203
Domain	THIOL_PROTEASE_CYS	CAPN8 CAPN1 CAPN2	1.03e-04	26	66	3	PS00139
Domain	THIOL_PROTEASE_ASN	CAPN8 CAPN1 CAPN2	1.16e-04	27	66	3	PS00640
Domain	THIOL_PROTEASE_HIS	CAPN8 CAPN1 CAPN2	1.16e-04	27	66	3	PS00639
Domain	Pept_cys_AS	CAPN8 CAPN1 CAPN2	1.30e-04	28	66	3	IPR000169
Domain	VDCCAlpha1	CACNA1D CACNA1I	5.43e-04	10	66	2	IPR002077
Domain	EF_HAND_1	CAPN8 CAPN1 CAPN2 PKD2 FLG2	7.71e-04	204	66	5	PS00018
Domain	Channel_four-helix_dom	CACNA1D PKD2 CACNA1I	1.08e-03	57	66	3	IPR027359
Domain	-	CACNA1D PKD2 CACNA1I	1.08e-03	57	66	3	1.20.120.350
Domain	EF_HAND_2	CAPN8 CAPN1 CAPN2 PKD2 FLG2	1.34e-03	231	66	5	PS50222
Domain	EF_hand_dom	CAPN8 CAPN1 CAPN2 PKD2 FLG2	1.37e-03	232	66	5	IPR002048
Domain	UBA-like	DMRTA2 UBXN1 CUEDC1	1.51e-03	64	66	3	IPR009060
Domain	-	CAPN8 CAPN1 CAPN2 PKD2 FLG2	2.29e-03	261	66	5	1.10.238.10
Domain	PH	IRS4 IQSEC2 OSBPL10 ARHGEF18 SH2B2	3.00e-03	278	66	5	SM00233
Domain	PH_DOMAIN	IRS4 IQSEC2 OSBPL10 ARHGEF18 SH2B2	3.05e-03	279	66	5	PS50003
Domain	PH_domain	IRS4 IQSEC2 OSBPL10 ARHGEF18 SH2B2	3.10e-03	280	66	5	IPR001849
Domain	EF_Hand_1_Ca_BS	CAPN8 CAPN1 CAPN2 FLG2	3.42e-03	175	66	4	IPR018247
Domain	EF-hand-dom_pair	CAPN8 CAPN1 CAPN2 PKD2 FLG2	3.44e-03	287	66	5	IPR011992
Domain	EF-hand_8	CAPN1 CAPN2	6.41e-03	34	66	2	PF13833
Pubmed	Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration.	CACNA1D CAPN1 CAPN2	2.61e-08	4	66	3	35606145
Pubmed	Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains.	CAPN8 CAPN1 CAPN2	6.51e-08	5	66	3	17646163
Pubmed	Engagement of the G3BP2-TRIM25 Interaction by Nucleocapsid Protein Suppresses the Type I Interferon Response in SARS-CoV-2-Infected Cells.	IRS4 CAPN1 NUFIP2 SRCAP HNRNPD	3.51e-07	76	66	5	36560452
Pubmed	The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle.	CAPN1 UBR4 CAPN2 UBXN1	4.09e-07	32	66	4	36278411
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	IRS4 ATG13 KIAA0232 IQSEC2 OSBPL10 CCDC85C ANKRD17 CLINT1 NEK9 ARAF RUSC2	6.24e-07	861	66	11	36931259
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	IRS4 DNAJC8 PGRMC2 NUFIP2 CCDC85C CLINT1 SRCAP PAF1 NEK9	9.49e-07	549	66	9	38280479
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TRO ATG13 SPEG KIAA0232 NUFIP2 SNX13 RUSC2 PDZD2	1.04e-06	407	66	8	12693553
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	MYC GPC1 LONP1 SMC3 CAPN1 UBR4 CAPN2 ANKRD17 UBXN1 SRCAP NEK9 SDC1 HNRNPD	1.32e-06	1353	66	13	29467282
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	MYC IRS4 TRO UBR4 ARHGEF18 CLINT1 APOBR NEK9	1.57e-06	430	66	8	35044719
Pubmed	Spatiotemporal Localisation of Heparan Sulphate Proteoglycans throughout Mouse Lens Morphogenesis.	GPC1 COL18A1 SDC1	2.34e-06	14	66	3	37408198
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	SMC3 UBR4 CAPN2 CCDC85C ANKRD17 ARAF	3.20e-06	212	66	6	33853758
Pubmed	PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma.	MYC PAF1	3.55e-06	2	66	2	38365788
Pubmed	Activation of calpains mediates early lung neutrophilic inflammation in ventilator-induced lung injury.	CAPN1 CAPN2	3.55e-06	2	66	2	22140070
Pubmed	[Expression of calpain 1 and calpain 2 during the skin incised wound healing in mice].	CAPN1 CAPN2	3.55e-06	2	66	2	17619446
Pubmed	Calpain 1 and 2 are required for RNA replication of echovirus 1.	CAPN1 CAPN2	3.55e-06	2	66	2	18032503
Pubmed	Calpain-2 participates in the process of calpain-1 inactivation.	CAPN1 CAPN2	3.55e-06	2	66	2	33078830
Pubmed	The CAPN2/CAPN8 Locus on Chromosome 1q Is Associated with Variation in Serum Alpha-Carotene Concentrations.	CAPN8 CAPN2	3.55e-06	2	66	2	28002826
Pubmed	Syndecan-1 and Glypican-1 Knockout Alters Body Water Balance and Urine Response to Fluid Challenge in Mice.	GPC1 SDC1	3.55e-06	2	66	2	33105135
Pubmed	Cloning of m-calpain 80 kD subunit from the axonal degeneration-resistant WLD(S) mouse mutant.	CAPN1 CAPN2	3.55e-06	2	66	2	9669314
Pubmed	Vitamin D₃ regulation of body fat, cytokines, and calpain gene expression.	CAPN1 CAPN2	3.55e-06	2	66	2	25520983
Pubmed	Deimination of human filaggrin-2 promotes its proteolysis by calpain 1.	CAPN1 FLG2	3.55e-06	2	66	2	21531719
Pubmed	Calpain activation contributes to hyperglycaemia-induced apoptosis in cardiomyocytes.	CAPN1 CAPN2	3.55e-06	2	66	2	19505932
Pubmed	Human RNA polymerase II associated factor 1 complex promotes tumorigenesis by activating c-MYC transcription in non-small cell lung cancer.	MYC PAF1	3.55e-06	2	66	2	26282204
Pubmed	Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion.	CAPN1 CAPN2	3.55e-06	2	66	2	15471877
Pubmed	m-Calpain is required for preimplantation embryonic development in mice.	CAPN1 CAPN2	3.55e-06	2	66	2	16433929
Pubmed	[Effect of high concentration of glucose on thickness of glycocalyx and expression of syndecan-1 and glypican-1 in cultured human renal glomerular endothelial cells].	GPC1 SDC1	3.55e-06	2	66	2	21265098
Pubmed	Calpains are required for invasive and metastatic potentials of human HCC cells.	CAPN1 CAPN2	3.55e-06	2	66	2	23733271
Pubmed	Involvement of calpains in growth factor-mediated migration.	CAPN1 CAPN2	3.55e-06	2	66	2	16971167
Pubmed	Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory.	CAPN1 CAPN2	3.55e-06	2	66	2	29258546
Pubmed	Protection against TBI-Induced Neuronal Death with Post-Treatment with a Selective Calpain-2 Inhibitor in Mice.	CAPN1 CAPN2	3.55e-06	2	66	2	28594313
Pubmed	Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer.	CAPN1 CAPN2	3.55e-06	2	66	2	22335024
Pubmed	Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice.	CAPN1 CAPN2	3.55e-06	2	66	2	27622212
Pubmed	Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases.	CAPN1 CAPN2	3.55e-06	2	66	2	19781581
Pubmed	Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury.	CAPN1 CAPN2	3.55e-06	2	66	2	27185592
Pubmed	Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.	CAPN1 CAPN2	3.55e-06	2	66	2	22432027
Pubmed	Cerebral calpain in fatal falciparum malaria.	CAPN1 CAPN2	3.55e-06	2	66	2	17359359
Pubmed	Repression of the TMEFF2 promoter by c-Myc.	MYC TMEFF2	3.55e-06	2	66	2	12729735
Pubmed	Hsa_Circ_0000826 inhibits the proliferation of colorectal cancer by targeting AUF1.	MYC HNRNPD	3.55e-06	2	66	2	35940521
Pubmed	Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects.	CAPN1 CAPN2	3.55e-06	2	66	2	30177812
Pubmed	Calpains: markers of tumor aggressiveness?	CAPN1 CAPN2	3.55e-06	2	66	2	20193680
Pubmed	Enzymatic cleavage of myoferlin releases a dual C2-domain module linked to ERK signalling.	MYOF CAPN1	3.55e-06	2	66	2	28192161
Pubmed	Different expression of calpains in the anterior vaginal wall of women with and without uterovaginal prolapse.	CAPN1 CAPN2	3.55e-06	2	66	2	14980313
Pubmed	Inhibition of calpain stabilises podosomes and impairs dendritic cell motility.	CAPN1 CAPN2	3.55e-06	2	66	2	16723743
Pubmed	Distinct roles for μ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration.	CAPN1 CAPN2	3.55e-06	2	66	2	24285894
Pubmed	Differential compartmentalization of the calpain/calpastatin network with the endoplasmic reticulum and Golgi apparatus.	CAPN1 CAPN2	3.55e-06	2	66	2	15302874
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	COL18A1 FAM53A ATG13 KIAA0232 CAPN1 PKD2 CCDC85C ANKRD17 ARHGEF18 NEK9 RAI1 TMEFF2 PDZD2	3.79e-06	1489	66	13	28611215
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	LONP1 SMC3 DNAJC8 IQSEC2 PGRMC2 NUFIP2 PKD2 DACT3 CCDC85C CLINT1 NEK9 ARAF	6.33e-06	1321	66	12	27173435
Pubmed	Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones.	GPC1 COL18A1 SDC1	8.47e-06	21	66	3	26116392
Pubmed	The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.	MYOF UBR4 PKD2 NEK9	9.32e-06	69	66	4	26792178
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	IRS4 PGRMC2 NUFIP2 DUT CCDC85C ANKRD17 CLINT1 SRCAP PAF1 NEK9	1.01e-05	934	66	10	33916271
Pubmed	Inhibition of calpain-1 stabilizes TCF11/Nrf1 but does not affect its activation in response to proteasome inhibition.	CAPN1 CAPN2	1.06e-05	3	66	2	30177525
Pubmed	The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation.	CAPN1 CAPN2	1.06e-05	3	66	2	28924170
Pubmed	Expression and immunolocalization of the calpain-calpastatin system in the human oocyte.	CAPN1 CAPN2	1.06e-05	3	66	2	15950654
Pubmed	Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemia.	CAPN1 CAPN2	1.06e-05	3	66	2	19318376
Pubmed	Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation.	MYC HNRNPD	1.06e-05	3	66	2	17486099
Pubmed	Proteomic profile identifies dysregulated pathways in Cornelia de Lange syndrome cells with distinct mutations in SMC1A and SMC3 genes.	MYC SMC3	1.06e-05	3	66	2	23106691
Pubmed	Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice.	CAPN1 CAPN2	1.06e-05	3	66	2	23977256
Pubmed	Abundance of calpain and aggrecan-cleavage products of calpain in degenerated human intervertebral discs.	CAPN1 CAPN2	1.06e-05	3	66	2	21839844
Pubmed	Extracellular Calpain/Calpastatin Balance Is Involved in the Progression of Pulmonary Hypertension.	CAPN1 CAPN2	1.06e-05	3	66	2	26974350
Pubmed	A novel role for calpain in the endothelial dysfunction induced by activation of angiotensin II type 1 receptor signaling.	CAPN1 CAPN2	1.06e-05	3	66	2	21415394
Pubmed	LOX-1 in macrophage migration in response to ox-LDL and the involvement of calpains.	CAPN1 CAPN2	1.06e-05	3	66	2	26393906
Pubmed	Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway.	CAPN1 CAPN2	1.06e-05	3	66	2	24550490
Pubmed	A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.	CAPN1 CAPN2	1.06e-05	3	66	2	28334907
Pubmed	Cell surface glypicans are low-affinity endostatin receptors.	GPC1 COL18A1	1.06e-05	3	66	2	11336704
Pubmed	The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration.	CAPN1 CAPN2	1.06e-05	3	66	2	18840650
Pubmed	Expression of typical calpains in mouse molar.	CAPN1 CAPN2	1.06e-05	3	66	2	19683220
Pubmed	NMDA and HIV-1 coat protein, GP120, produce necrotic but not apoptotic cell death in human CHP100 neuroblastoma cultures via a mechanism involving calpain.	CAPN1 CAPN2	1.06e-05	3	66	2	8954122
Pubmed	The novel benzimidazole derivative, MPTB, induces cell apoptosis in human chondrosarcoma cells.	CAPN1 CAPN2	1.06e-05	3	66	2	21374734
Pubmed	The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer.	MYC TMEFF2	1.06e-05	3	66	2	24919179
Pubmed	Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer.	GPC1 SDC1	1.06e-05	3	66	2	15297422
Pubmed	Protein kinase Ciota promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of micro- and m-calpains.	CAPN1 CAPN2	1.06e-05	3	66	2	16361262
Pubmed	Neurotoxicity induces cleavage of p35 to p25 by calpain.	CAPN1 CAPN2	1.06e-05	3	66	2	10830966
Pubmed	Utrophin is a calpain substrate in muscle cells.	CAPN1 CAPN2	1.06e-05	3	66	2	16598790
Pubmed	Ubiquitous calpains promote both apoptosis and survival signals in response to different cell death stimuli.	CAPN1 CAPN2	1.06e-05	3	66	2	16632474
Pubmed	ING4 inhibits the translation of proto-oncogene MYC by interacting with AUF1.	MYC HNRNPD	1.06e-05	3	66	2	23603392
Pubmed	Interaction of human calpains I and II with high molecular weight and low molecular weight kininogens and their heavy chain: mechanism of interaction and the role of divalent cations.	CAPN1 CAPN2	1.06e-05	3	66	2	3038169
Pubmed	Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury.	CAPN1 CAPN2	1.06e-05	3	66	2	23536090
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	LONP1 SMC3 UBR4 CAPN2 PAF1 TENT2	1.63e-05	282	66	6	23667531
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	GPC1 DNAJC8 CAPN1 UBR4 CAPN2 DUT CLINT1 UBXN1 PAF1 NEK9 STK24 HNRNPD	1.67e-05	1455	66	12	22863883
Pubmed	Network organization of the human autophagy system.	COL18A1 LONP1 IRS4 SMC3 ATG13 CLINT1 NEK9	1.94e-05	437	66	7	20562859
Pubmed	Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer.	CAPN1 CAPN2	2.12e-05	4	66	2	27456359
Pubmed	Inhibition of the ERK1/2-ubiquitous calpains pathway attenuates experimental pulmonary fibrosis in vivo and in vitro.	CAPN1 CAPN2	2.12e-05	4	66	2	32017927
Pubmed	Characterization of the calcium-dependent proteolytic system in a mouse muscle cell line.	CAPN1 CAPN2	2.12e-05	4	66	2	11952156
Pubmed	Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.	CAPN1 CAPN2	2.12e-05	4	66	2	16998475
Pubmed	17-Beta-estradiol increases neuronal excitability through MAP kinase-induced calpain activation.	CAPN1 CAPN2	2.12e-05	4	66	2	19995977
Pubmed	Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens.	CAPN1 CAPN2	2.12e-05	4	66	2	12634108
Pubmed	Exome analysis of Smith-Magenis-like syndrome cohort identifies de novo likely pathogenic variants.	IQSEC2 RAI1	2.12e-05	4	66	2	28213671
Pubmed	Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin.	MYC PKD2	2.12e-05	4	66	2	19939939
Pubmed	Calcium-dependent signaling pathways in T cells. Potential role of calpain, protein tyrosine phosphatase 1b, and p130Cas in integrin-mediated signaling events.	CAPN1 CAPN2	2.12e-05	4	66	2	9407132
Pubmed	Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation.	MYC BHLHE40	2.12e-05	4	66	2	27765932
Pubmed	The calpain family and human disease.	CAPN8 CAPN1	2.12e-05	4	66	2	11516996
Pubmed	Regional differences in gene expression for calcium activated neutral proteases (calpains) and their endogenous inhibitor calpastatin in mouse brain and spinal cord.	CAPN1 CAPN2	2.12e-05	4	66	2	8738748
Pubmed	Calpain: novel family members, activation, and physiologic function.	CAPN1 CAPN2	2.12e-05	4	66	2	8561910
Pubmed	Four genes for the calpain family locate on four distinct human chromosomes.	CAPN1 CAPN2	2.12e-05	4	66	2	2209092
Pubmed	Synchronous and regulated expression of two AU-binding proteins, AUF1 and HuR, throughout murine development.	MYC HNRNPD	2.12e-05	4	66	2	11103939
Pubmed	The inhibition of calpains ameliorates vascular restenosis through MMP2/TGF-β1 pathway.	CAPN1 CAPN2	2.12e-05	4	66	2	27453531
Pubmed	Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice.	CAPN1 CAPN2	2.12e-05	4	66	2	26966280
Pubmed	Calpains mediate epithelial-cell death during mammary gland involution: mitochondria and lysosomal destabilization.	CAPN1 CAPN2	2.12e-05	4	66	2	22555453
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	COL18A1 ITPKC LONP1 IRS4 CAPN1 UBR4 ANKRD17 CLINT1	2.80e-05	639	66	8	23443559
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	IRS4 SMC3 NUFIP2 CLINT1 FLG2 HNRNPD ARAF	3.39e-05	477	66	7	31300519
Interaction	YAP1 interactions	MYC COL18A1 IRS4 DNAJC8 SUN2 CAPN1 PGRMC2 NUFIP2 CCDC85C CLINT1 FLG2 SRCAP PAF1 NEK9 HNRNPD CUEDC1	2.70e-07	1095	65	16	int:YAP1
GeneFamily	C2 domain containing\|Calpains	CAPN8 CAPN1 CAPN2	5.59e-06	15	43	3	975
GeneFamily	EF-hand domain containing	CAPN8 CAPN1 CAPN2 PKD2 FLG2	1.65e-04	219	43	5	863
GeneFamily	Calcium voltage-gated channel subunits	CACNA1D CACNA1I	1.73e-03	26	43	2	253
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	OSBPL10 ARHGEF18 SH2B2	1.29e-02	206	43	3	682
Coexpression	GSE28726_ACT_CD4_TCELL_VS_ACT_VA24NEG_NKTCELL_DN	ATG13 SUN2 PGRMC2 CAPN2 ARHGEF18 SRCAP	1.14e-05	200	66	6	M8306
Coexpression	NAGASHIMA_NRG1_SIGNALING_UP	MYC ITPKC EGR4 BHLHE40 STK24	7.42e-05	172	66	5	M11585
Coexpression	HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN	MYC LONP1 KLHL21 CAPN2 BHLHE40 SDC1	7.78e-05	282	66	6	M7623
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP	SPEG SDC1 TENT2 SNX13 PDZD2	7.84e-05	174	66	5	M1113
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP	SPEG SDC1 TENT2 SNX13 PDZD2	8.50e-05	177	66	5	MM479
Coexpression	TAKADA_GASTRIC_CANCER_COPY_NUMBER_UP	MYC SDC1	1.30e-04	7	66	2	M2212
Coexpression	HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL	GPC1 COL18A1 DMKN SSH3 SPEG PGRMC2 CCDC85C FAM110C STK24 PDZD2	1.30e-04	955	66	10	M45680
Coexpression	GSE24671_CTRL_VS_SENDAI_VIRUS_INFECTED_MOUSE_SPLENOCYTES_DN	SUN2 ZBTB4 NUFIP2 CLINT1 RAI1	1.47e-04	199	66	5	M9443
Coexpression	GSE24574_BCL6_HIGH_VS_LOW_TFH_CD4_TCELL_UP	ATG13 SUN2 ARHGEF18 UBXN1 SRCAP	1.47e-04	199	66	5	M8324
Coexpression	GSE22229_RENAL_TRANSPLANT_IMMUNOSUPP_THERAPY_VS_HEALTHY_PBMC_DN	GPC1 DMKN SH2B2 TENT2 TXNDC11	1.47e-04	199	66	5	M7479
Coexpression	GSE40184_HEALTHY_VS_HCV_INFECTED_DONOR_PBMC_DN	GPC1 AEBP2 CLINT1 BHLHE40 STK24	1.51e-04	200	66	5	M9404
Coexpression	GSE14308_TH1_VS_NAIVE_CD4_TCELL_UP	LONP1 PGRMC2 AEBP2 APOBR BHLHE40	1.51e-04	200	66	5	M3376
Coexpression	GSE5589_LPS_VS_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN	DMKN TRO KIAA0232 BHLHE40 TENT2	1.51e-04	200	66	5	M6610
Coexpression	GSE33162_HDAC3_KO_VS_HDAC3_KO_4H_LPS_STIM_MACROPHAGE_UP	DNAJC8 RNF185 ANKRD17 NEK9 HNRNPD	1.51e-04	200	66	5	M9041
Coexpression	GSE17721_LPS_VS_POLYIC_12H_BMDC_DN	EGR4 SUN2 DUT STK24 SDC1	1.51e-04	200	66	5	M3817
Coexpression	YANG_BCL3_TARGETS_DN	SUN2 SH2B2	1.73e-04	8	66	2	M2425
ToppCell	Skin-Keratinocytes\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	MYC GPC1 DMKN KLHL21 CAPN1 UBR4 SDC1	1.93e-08	200	66	7	59d72395199bc30df0e811fbc99149694e208860
ToppCell	facs-Skin-Anagen-3m-Epithelial\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL18A1 MYOF SUN2 CAPN1 CAPN2 SDC1	3.86e-07	190	66	6	888ded899f0513d41bf655896d59ae8ef74e0978
ToppCell	facs-Skin-Anagen-3m\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL18A1 MYOF SUN2 CAPN1 CAPN2 SDC1	3.86e-07	190	66	6	3466cebab16964e94da130d0673fa32e7d90b5ed
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPC1 MYOF ITPKC KLHL21 BHLHE40 SDC1	4.77e-07	197	66	6	233b9fcb376e08d0080a05ca0198ecc6ec720f90
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPC1 MYOF CAPN1 FAM110C BHLHE40 SDC1	5.06e-07	199	66	6	c88a28a73f54dc571f2ff1e4b55073f83cbead2c
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYOF ITPKC CAPN2 BHLHE40 SDC1	6.03e-06	174	66	5	207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCell	facs-Heart-RA-18m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYC CLINT1 BHLHE40 STK24 HNRNPD	6.73e-06	178	66	5	b505e2550860e777535ee95f29c936242fd607f1
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYC CAPN8 ITPKC LONP1 DMKN	8.78e-06	188	66	5	2b8d70f761eda5509f21845a87cdb3602a639dd7
ToppCell	facs-Skin-Anagen\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL18A1 MYOF SUN2 CAPN1 SDC1	9.01e-06	189	66	5	adbfc723130079b4caf551f66d2aee86fab1903c
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYC GPC1 CAPN1 FAM110C SDC1	9.48e-06	191	66	5	4180521a8c5e0ad629cacdd22dc6a94e94b28816
ToppCell	facs-Skin-Anagen-3m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL18A1 MYOF SUN2 CAPN2 SDC1	9.97e-06	193	66	5	eba3c70701b051bc1ed1f4db9270cb27a77ffc3e
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYC OSBPL10 SH2B2 SDC1 TXNDC11	9.97e-06	193	66	5	1b7d17ef85bbe57adfdf68b728978c4d5521a298
ToppCell	facs-Skin-Anagen-3m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL18A1 MYOF SUN2 CAPN2 SDC1	1.02e-05	194	66	5	5d30d3d41d5f19cdf3077cc609aa2738762cb8c5
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPC1 ITPKC CAPN1 BHLHE40 SDC1	1.10e-05	197	66	5	1d4ccca2ff46fccb3ac052b5148cb7f94231d65a
ToppCell	facs-Trachea-3m\|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SUN2 CAPN2 NUFIP2 PKD2 BHLHE40	1.10e-05	197	66	5	e77016d64b1cac9825fec7cfe5071f1567401187
ToppCell	facs-Trachea-nan-3m\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SUN2 CAPN2 NUFIP2 PKD2 BHLHE40	1.10e-05	197	66	5	0353d925ee4b7aefc2c51b5fab873f465cdf9ebc
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYOF CAPN1 CLINT1 BHLHE40 SDC1	1.13e-05	198	66	5	3cc9e671f596ef0829684018e4257571fefb6267
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPC1 MYOF CAPN1 FAM110C SDC1	1.13e-05	198	66	5	22935a8afac54021f68b5f7a5accf51523e2f336
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GPC1 MYOF DMKN PKD2 TXNDC11	1.16e-05	199	66	5	174f6013af6eafa577f84205a62927f2b367fda3
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SZT2 UBR4 SRCAP APOBR STK24	1.16e-05	199	66	5	379bbd9cecf466b902411c54d74bd9885285b1ba
ToppCell	control-Epithelial-Secretory\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	GPC1 MYOF CLINT1 BHLHE40 SDC1	1.16e-05	199	66	5	262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL18A1 MYOF DMKN CAPN2 SDC1	1.18e-05	200	66	5	d9dab2aed11e45c60d11ff0c5af1f2fbb9cb45d8
ToppCell	proximal-3-Epithelial-Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYC GPC1 CAPN1 FAM110C SDC1	1.18e-05	200	66	5	8083047c213488e40b975013e3c5c43f7c0c15b2
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL18A1 MYOF DMKN CAPN2 SDC1	1.18e-05	200	66	5	33b7af6c50e65dc1bdf429572574ed072f8bc29f
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	GPC1 DMKN CAPN1 BHLHE40 SDC1	1.18e-05	200	66	5	ea1325ca6039c6d2318b1ceb9d396399bb21b670
ToppCell	proximal-Epithelial-Basal\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYC GPC1 CAPN1 FAM110C SDC1	1.18e-05	200	66	5	c6a491d3e2dae6618f25dc3c9aac08f657348168
ToppCell	proximal-Epithelial-Basal-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYC GPC1 CAPN1 FAM110C SDC1	1.18e-05	200	66	5	f5d48f521abbd1e07de05f2b3768ad2f9675f1e1
ToppCell	distal-Epithelial-Basal-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GPC1 DMKN DMRTA2 FAM110C SDC1	1.18e-05	200	66	5	6f00d08e93f89b3575ebbd5c2f451e655d449ef3
ToppCell	P15-Epithelial-epithelial_progenitor_cell-epi_progenitor\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MYOF DMKN CCDC85C SDC1	9.13e-05	159	66	4	a4bfd59c53237964fc24a24de5c1925fdd01db99
ToppCell	facs-Spleen-nan-3m-Lymphocytic-NK_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC1 CAPN2 BHLHE40 CUEDC1	1.03e-04	164	66	4	a187bd5beca017ef657ef07c006e7f94ea3b911b
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYC CAPN8 DMKN SDC1	1.38e-04	177	66	4	75cb2067a3f2d1b5a964890b02b604d1e79bd163
ToppCell	droplet-Spleen-SPLEEN-1m-Lymphocytic-plasma_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1D RNF185 SDC1 TXNDC11	1.41e-04	178	66	4	b902059c3f861108fc64cbdc05e6f44378f5be2c
ToppCell	facs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ODAD1 KIAA0232 RNF185 SH2B2	1.47e-04	180	66	4	7368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN8 MYOF FAM110C RAI1	1.54e-04	182	66	4	a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell	5'-Adult-LymphNode-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZBTB4 PKD2 DACT3 SH2B2	1.57e-04	183	66	4	d67454baf0cf791a743b51afd1cb25bfb5765385
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYC CAPN8 DMKN SDC1	1.57e-04	183	66	4	ec2af3402b51f11466d2a5783a6b33746b6a7fc9
ToppCell	5'-Adult-LymphNode-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZBTB4 PKD2 DACT3 SH2B2	1.57e-04	183	66	4	e49ac8314b6fe98426b1514ea68d646297b8bc0f
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-naive_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYC GPC1 LONP1 DMKN	1.63e-04	185	66	4	3f1aa91efae2d00320d126087cce1431ad5f26ea
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-naive_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYC GPC1 LONP1 DMKN	1.67e-04	186	66	4	744bf39af2fb5a7454477174d7755a6d78cd279f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN8 MYOF PKD2 FAM110C	1.70e-04	187	66	4	87b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN8 MYOF PKD2 FAM110C	1.70e-04	187	66	4	42a1267bfc27b4460b8409ada580a87c4385841c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN8 MYOF PKD2 FAM110C	1.70e-04	187	66	4	64afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYC PGRMC2 CACNA1I PAF1	1.74e-04	188	66	4	939790f133eac9c12d08db6ddb5f08f5107844e3
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CAPN8 MYOF CAPN2 CCDC85C	1.74e-04	188	66	4	43a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYC MYOF DMKN BHLHE40	1.77e-04	189	66	4	562f8bf5a7d38afb4a8f2415d617d5f79cfb7e3f
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYC MYOF DMKN BHLHE40	1.77e-04	189	66	4	270dd4a0fc5260288fe6829837942c78b40ecec4
ToppCell	PND07-28-samps-Mesenchymal-Matrix_fibroblast-FB-3\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	GPC1 CACNA1D COL18A1 DACT3	1.81e-04	190	66	4	1196b8ea2c44c7c80f5ee589dd517e6a413f2077
ToppCell	Basal_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	GPC1 COL18A1 TRO SDC1	1.85e-04	191	66	4	a98915bad9a4a61dd4cbca798914849b805f4a19
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN8 MYOF CLINT1 FAM110C	1.85e-04	191	66	4	5a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN8 MYOF CLINT1 FAM110C	1.85e-04	191	66	4	55ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCell	COVID-19-Lymphoid-Plasma,_B_cells\|Lymphoid / Condition, Lineage and Cell class	OSBPL10 SH2B2 SDC1 TXNDC11	1.85e-04	191	66	4	bcdadf83cb9653f9cc2a281e7c1095fe8f79173c
ToppCell	18-Distal-Epithelial-Secretory_progenitor\|Distal / Age, Tissue, Lineage and Cell class	CAPN8 DMKN SRCAP BHLHE40	1.88e-04	192	66	4	9fae988ecd2ef1231bfd42a678a4903517694cbe
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Basal/Suprabasal\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GPC1 MYOF DMKN SDC1	1.92e-04	193	66	4	7c34abdcb8839b9fb25457a79af6c5e7b9714b21
ToppCell	facs-Marrow-KLS-18m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC1 LONP1 DMKN SH2B2	1.92e-04	193	66	4	f92bbe70e6c725bfb8c08bfc2a94e375528151a3
ToppCell	facs-Marrow-KLS-18m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC1 LONP1 DMKN SH2B2	1.92e-04	193	66	4	44ba79db566d0fa3bbcfe3adf9164bf8c3cb0bc3
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-Plasma_cell\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PGRMC2 SH2B2 SDC1 TXNDC11	1.96e-04	194	66	4	297286c57d7ee6338d9cf77b27eb2809378ce15d
ToppCell	18-Airway-Epithelial-Secretory_progenitor\|Airway / Age, Tissue, Lineage and Cell class	CAPN8 SRCAP BHLHE40 SDC1	1.96e-04	194	66	4	9a2efa50731135a178141aae55fa8b3e022c9904
ToppCell	Control-B_memory-3\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	COL18A1 SUN2 CAPN2 OSBPL10	2.00e-04	195	66	4	135234f068da3e8db7213b53c09ed6d1d0cdc351
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL18A1 EGR4 DMKN SDC1	2.00e-04	195	66	4	66caa5c063184e7d3d653c8f6c289555cb36fa82
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL18A1 EGR4 DMKN SDC1	2.00e-04	195	66	4	ed74c113074fb5d3c42f2330b0e6042d32c3611a
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL18A1 EGR4 DMKN SDC1	2.00e-04	195	66	4	17c4d3b59cd0d79ce9ae5dde95586f3e923db16f
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYOF CAPN1 BHLHE40 SDC1	2.00e-04	195	66	4	24d226f89dd337c22728688e4b40ca082a0e1fe1
ToppCell	Enterocyte-C_05\|Enterocyte / shred on cell type and cluster	CAPN8 MYOF CAPN2 APOBR	2.04e-04	196	66	4	c307e5a70186567c62da938caa21749dc0e929d0
ToppCell	distal-3-Epithelial-Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYC GPC1 DMKN SDC1	2.08e-04	197	66	4	72ac9068cfd8f04c521a858d55eb8b5764de0282
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPC1 PKD2 DACT3 SDC1	2.08e-04	197	66	4	3fe665c0277d091290b63f0dd24c0c6536a45309
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPC1 MYOF CAPN1 SDC1	2.08e-04	197	66	4	2430f31d9312338e0ca23bfc6bdb0365340860fd
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPC1 MYOF CAPN1 SDC1	2.12e-04	198	66	4	9718f4c013c347f1b3c785ae232dd2fb6c1fe298
ToppCell	cellseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Suprabasal\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GPC1 CAPN1 BHLHE40 SDC1	2.12e-04	198	66	4	6e047de63ef59dcb47e4fc06b173b2a02fdcf4c9
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPC1 MYOF CAPN1 SDC1	2.12e-04	198	66	4	89ec1e760a193441092571475cc66a3b425f232e
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYC ITPKC KLHL21 FAM110C	2.12e-04	198	66	4	77517df37dc894c78ef1e2b24dd7ba31f928bdb7
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYC GPC1 MYOF FAM110C	2.12e-04	198	66	4	fc00cb25cdc6c31b7f9d397bc9f9a8f4e9708003
ToppCell	Skin\|World / Skin and Kidney Cells in Lupus Nephritis Patients.	MYC GPC1 DMKN SDC1	2.16e-04	199	66	4	6be1340413ee868c610b6e3f58c65b493eb22bb5
ToppCell	Biopsy_Other_PF-Epithelial-AT2\|Biopsy_Other_PF / Sample group, Lineage and Cell type	CAPN8 DMKN SDC1 PDZD2	2.16e-04	199	66	4	9a65acfe9bf500db72142469cf17bf0973540001
ToppCell	suprabasal_cell\|World / shred by cell class for turbinate	MYOF CAPN1 BHLHE40 SDC1	2.16e-04	199	66	4	bfab5380ef074d14f0b5ed10851ad5c898eb9a58
ToppCell	Transverse-Macrophage-LYVE1_Macrophage\|Transverse / Region, Cell class and subclass	MYOF LRP3 FLG2 CUEDC1	2.16e-04	199	66	4	facf79c256db5ae57bdb613e86ec90616a6f67ca
ToppCell	Transverse-(6)_Macrophage-(61)_LYVE1_Macrophage\|Transverse / shred on region, Cell_type, and subtype	MYOF LRP3 FLG2 CUEDC1	2.16e-04	199	66	4	dcc2a7f4d1fa30aaaad655dd59c5a2b039d264bf
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MYC CAPN2 SRCAP FAM110C	2.16e-04	199	66	4	85bb28369e0568b7b3bda095722102fc793f60ef
ToppCell	NS-control-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	GPC1 MYOF BHLHE40 SDC1	2.16e-04	199	66	4	32bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPC1 MYOF CAPN1 SDC1	2.16e-04	199	66	4	ba284f984909504221900bca5ea12ada5b2ffd9f
ToppCell	control-Epithelial\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MYOF DMKN CAPN2 SDC1	2.20e-04	200	66	4	f95bbb94e51ac28b1995026c599ec3a34e012916
ToppCell	NS-control-d_0-4-Epithelial\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MYOF DMKN CAPN2 SDC1	2.20e-04	200	66	4	d014959891893b6d3854a471fba1dc50c6625a0a
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYC GPC1 EGR4 SDC1	2.20e-04	200	66	4	83afe771e9041c98703d8bad928a98cde601b704
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-squamous_epithelial_cell-Epi-Squamous\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYC EGR4 CAPN2 DUT	2.20e-04	200	66	4	8231655c1f14c5a0cb081b25ecaccc1c62bd588f
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Epithelial\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYC GPC1 EGR4 SDC1	2.20e-04	200	66	4	f611335436bb74d22496f7872dff2110c3d3061f
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-squamous_epithelial_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYC EGR4 CAPN2 DUT	2.20e-04	200	66	4	05262530ce87cfdd6bcbce5ae03cf4e3f9a74a02
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Basal_2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	GPC1 MYOF ITPKC SDC1	2.20e-04	200	66	4	0fa3340d945f00ef55c7603476d51bd8346e82c2
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	CAPN2 CLINT1 BHLHE40 HNRNPD	2.20e-04	200	66	4	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GPC1 DMKN FAM110C SDC1	2.20e-04	200	66	4	2a9d715aba8bdef2341b0d44ff60825c074a4b03
ToppCell	distal-2-Epithelial-Basal\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GPC1 DMKN FAM110C SDC1	2.20e-04	200	66	4	9beb128841c50241aa819261f21bf66f881ea125
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_Hsd17b2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MYOF DMKN ARHGEF18	2.37e-04	81	66	3	20796e59cdeb398e7772f4356578d74a33405f71
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-CR\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DMRTA2 FAM110C SDC1	2.55e-04	83	66	3	1ab68323518adc7fd0a459b41fad12d60f97eb5c
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-CR-CR_Lhx5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DMRTA2 FAM110C SDC1	2.55e-04	83	66	3	75b27d91a4473286f4b40027e96ac5246f5abe5b
ToppCell	(01)_Cycling_Basal_(homeostasis)-(2)_48hpi\|(01)_Cycling_Basal_(homeostasis) / shred by cell type and Timepoint	SLC25A46 KIAA0232	3.19e-04	18	66	2	80d5417681a700e289025f3657bfabbb0abcf043
Drug	Withaferin A [5119-48-2]; Up 200; 1uM; PC3; HT_HG-U133A	CACNA1D IRS4 EGR4 KLHL21 KIAA0232 CACNA1I RUSC2	9.37e-07	181	66	7	3819_UP
Drug	Amoxapine [14028-44-5]; Up 200; 12.8uM; PC3; HG-U133A	GPC1 SSH3 CAPN1 PGRMC2 LRP3 CUEDC1 RUSC2	1.77e-06	199	66	7	1931_UP
Drug	0317956-0000 [391210-11-0]; Down 200; 1uM; MCF7; HT_HG-U133A	SSH3 IQSEC2 SRCAP STK24 CUEDC1 RUSC2	2.10e-05	194	66	6	3969_DN
Drug	6-mercaptopurine monohydrate; Up 200; 100uM; MCF7; HG-U133A	GPC1 ATG13 SPEG PGRMC2 CACNA1I SRCAP	2.10e-05	194	66	6	334_UP
Drug	Clindamycin hydrochloride [21462-39-5]; Down 200; 8.6uM; MCF7; HT_HG-U133A	MYOF KLHL21 ATG13 SSH3 IQSEC2 BHLHE40	2.23e-05	196	66	6	2219_DN
Drug	Metoprolol-(+,-) (+)-tartrate salt [56392-17-7]; Down 200; 5.8uM; MCF7; HT_HG-U133A	GPC1 CACNA1D CCDC85C SRCAP NEK9 RUSC2	2.29e-05	197	66	6	6106_DN
Drug	Epirizole [18694-40-1]; Down 200; 17uM; PC3; HT_HG-U133A	ATG13 LRP3 CCDC85C SRCAP CUEDC1 RUSC2	2.29e-05	197	66	6	1803_DN
Drug	Mexiletine hydrochloride [5370-01-4]; Down 200; 18.6uM; MCF7; HT_HG-U133A	CACNA1D MYOF ITPKC DNAJC8 KLHL21 CCDC85C	2.29e-05	197	66	6	2324_DN
Drug	Saquinavir mesylate [149845-06-7]; Down 200; 5.2uM; PC3; HT_HG-U133A	ITPKC CAPN2 LRP3 UBXN1 SRCAP RUSC2	2.29e-05	197	66	6	5770_DN
Drug	Proparacaine hydrochloride [5875-06-9]; Up 200; 12uM; PC3; HT_HG-U133A	MYOF CCDC85C CACNA1I UBXN1 STK24 SNX13	2.36e-05	198	66	6	6332_UP
Drug	Delcorine; Down 200; 8.4uM; MCF7; HT_HG-U133A	MYOF IQSEC2 CCDC85C CACNA1I SRCAP BHLHE40	2.43e-05	199	66	6	6033_DN
Drug	mibefradil	CACNA1D PKD2 CACNA1I PAF1	3.59e-05	64	66	4	CID000060662
Drug	gallopamil	CACNA1D PKD2 CACNA1I PAF1	4.30e-05	67	66	4	CID000001234
Drug	Niclosamide [50-65-7]; Up 200; 12.2uM; MCF7; HT_HG-U133A	MYC MYOF ATG13 SRCAP BHLHE40	9.60e-05	158	66	5	4136_UP
Drug	CNS 1145	CACNA1D PKD2 CACNA1I	1.19e-04	33	66	3	CID000190902
Drug	IHC-64	CACNA1D PKD2 CACNA1I	1.19e-04	33	66	3	CID000162753
Drug	AC1NUZ8M	CACNA1D PKD2 CACNA1I PAF1	1.49e-04	92	66	4	CID000073211
Drug	17-AAG; Up 200; 1uM; PC3; HG-U133A	ATG13 ARHGEF18 NEK9 HNRNPD PDZD2	2.06e-04	186	66	5	432_UP
Drug	Securinine [5610-40-2]; Up 200; 18.4uM; MCF7; HT_HG-U133A	KIAA0232 CAPN2 SRCAP SNX13 CUEDC1	2.06e-04	186	66	5	6831_UP
Drug	17-AAG; Up 200; 1uM; HL60; HT_HG-U133A	ITPKC SSH3 IQSEC2 PAF1 HNRNPD	2.11e-04	187	66	5	1147_UP
Drug	Betulinic acid [472-15-1]; Up 200; 8.8uM; MCF7; HT_HG-U133A	MYOF KIAA0232 CCDC85C BHLHE40 RUSC2	2.16e-04	188	66	5	3281_UP
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A_EA	MYC GPC1 SSH3 LRP3 SRCAP	2.16e-04	188	66	5	986_DN
Drug	H-7 dihydrochloride; Down 200; 100uM; MCF7; HT_HG-U133A	MYC KLHL21 KIAA0232 BHLHE40 HNRNPD	2.22e-04	189	66	5	5936_DN
Drug	Methiothepin maleate [19728-88-2]; Up 200; 8.4uM; MCF7; HT_HG-U133A	EGR4 CACNA1I SRCAP BHLHE40 NEK9	2.22e-04	189	66	5	5413_UP
Drug	resveratrol; Up 200; 50uM; PC3; HG-U133A	GPC1 ATG13 SPEG PGRMC2 NEK9	2.33e-04	191	66	5	662_UP
Drug	Sanguinarine [2447-54-3]; Down 200; 12uM; MCF7; HT_HG-U133A	MYOF UBR4 CCDC85C NEK9 HNRNPD	2.33e-04	191	66	5	4168_DN
Drug	Cyanocobalamin [68-19-9]; Down 200; 3uM; MCF7; HT_HG-U133A	KLHL21 CCDC85C UBXN1 SRCAP SNX13	2.38e-04	192	66	5	4395_DN
Drug	deferoxamine mesylate salt; Up 200; 100uM; MCF7; HG-U133A	ATG13 PGRMC2 CCDC85C CACNA1I BHLHE40	2.38e-04	192	66	5	485_UP
Drug	Isotretinoin [4759-48-2]; Up 200; 13.4uM; PC3; HT_HG-U133A	GPC1 LRP3 SRCAP SNX13 RUSC2	2.44e-04	193	66	5	7315_UP
Drug	Roxarsone	FAM53A PGRMC2 HNRNPD	2.46e-04	42	66	3	ctd:D012406
Drug	Streptozotocin [18883-66-4]; Up 200; 15uM; PC3; HT_HG-U133A	SSH3 IQSEC2 CACNA1I SRCAP SNX13	2.50e-04	194	66	5	5836_UP
Drug	ICI182,780; Down 200; 1uM; MCF7; HT_HG-U133A	MYC CACNA1D TRO STK24 CUEDC1	2.50e-04	194	66	5	7534_DN
Drug	(-) -Levobunolol hydrochloride [27912-14-7]; Down 200; 12.2uM; MCF7; HT_HG-U133A	GPC1 IQSEC2 STK24 CUEDC1 RUSC2	2.50e-04	194	66	5	4134_DN
Drug	Tocopherol (R,S) [10191-41-0]; Down 200; 9.2uM; PC3; HT_HG-U133A	ITPKC SSH3 IQSEC2 CAPN2 SRCAP	2.50e-04	194	66	5	6616_DN
Drug	Etanidazole [22668-01-5]; Down 200; 18.6uM; MCF7; HT_HG-U133A	KLHL21 SSH3 IQSEC2 CACNA1I SNX13	2.50e-04	194	66	5	6072_DN
Drug	Sulfaquinoxaline sodium salt [967-80-6]; Down 200; 12.4uM; MCF7; HT_HG-U133A	UBXN1 SRCAP BHLHE40 NEK9 RUSC2	2.50e-04	194	66	5	6090_DN
Drug	Dinoprost trometamol [38362-01-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A	GPC1 CACNA1D DNAJC8 UBXN1 SNX13	2.50e-04	194	66	5	3308_UP
Drug	Tiabendazole [148-79-8]; Up 200; 19.8uM; MCF7; HT_HG-U133A	GPC1 TRO UBR4 CACNA1I STK24	2.56e-04	195	66	5	4402_UP
Drug	Xylazine [7361-61-7]; Up 200; 18.2uM; HL60; HT_HG-U133A	CACNA1D COL18A1 UBR4 NEK9 RUSC2	2.56e-04	195	66	5	2132_UP
Drug	Ribostamycin sulfate salt [53797-35-6]; Down 200; 7.2uM; HL60; HT_HG-U133A	MYOF SSH3 LRP3 CCDC85C RUSC2	2.56e-04	195	66	5	2705_DN
Drug	Moxisylyte hydrochoride [964-52-3]; Up 200; 12.6uM; PC3; HT_HG-U133A	MYOF EGR4 STK24 SNX13 RUSC2	2.56e-04	195	66	5	7255_UP
Drug	estradiol, USP; Down 200; 0.01uM; HL60; HT_HG-U133A	GPC1 SSH3 CAPN1 IQSEC2 SNX13	2.56e-04	195	66	5	2701_DN
Drug	wortmannin from Penicillium funiculosum; Up 200; 0.01uM; HL60; HT_HG-U133A	MYOF SSH3 IQSEC2 ARHGEF18 RUSC2	2.56e-04	195	66	5	1184_UP
Drug	2-propylpentanoic acid; Down 200; 500uM; MCF7; HT_HG-U133A_EA	MYC COL18A1 SMC3 ATG13 HNRNPD	2.56e-04	195	66	5	1078_DN
Drug	Oxybenzone [131-57-7]; Down 200; 17.6uM; PC3; HT_HG-U133A	GPC1 ITPKC LRP3 CCDC85C SRCAP	2.62e-04	196	66	5	6309_DN
Drug	Quinic acid [86-68-0]; Down 200; 19.6uM; PC3; HT_HG-U133A	MYOF SZT2 ATG13 CAPN2 CCDC85C	2.62e-04	196	66	5	7317_DN
Drug	Perhexiline maleate [6724-53-4]; Down 200; 10.2uM; PC3; HT_HG-U133A	SPEG SRCAP NEK9 STK24 RUSC2	2.62e-04	196	66	5	5081_DN
Drug	Mevalonic-D, L acid lactone [674-26-0]; Down 200; 30.8uM; HL60; HT_HG-U133A	MYOF SZT2 CLINT1 BHLHE40 NEK9	2.62e-04	196	66	5	2718_DN
Drug	Epicatechin-(-) [154-23-4]; Down 200; 13.8uM; MCF7; HT_HG-U133A	IQSEC2 UBXN1 SRCAP NEK9 PDZD2	2.62e-04	196	66	5	4419_DN
Drug	Nicergoline; Down 200; 8.2uM; PC3; HT_HG-U133A	MYOF SSH3 CCDC85C ANKRD17 SRCAP	2.62e-04	196	66	5	2058_DN
Drug	Isopyrin hydrochloride [18342-39-7]; Down 200; 14.2uM; HL60; HT_HG-U133A	EGR4 SSH3 CACNA1I UBXN1 NEK9	2.62e-04	196	66	5	2534_DN
Drug	Calciferol [50-14-6]; Up 200; 10uM; HL60; HT_HG-U133A	COL18A1 CCDC85C UBXN1 STK24 SNX13	2.62e-04	196	66	5	2442_UP
Drug	haloperidol; Down 200; 10uM; HL60; HT_HG-U133A	SSH3 IQSEC2 SRCAP SNX13 RUSC2	2.62e-04	196	66	5	6203_DN
Drug	Moricizine hydrochloride [31883-05-3]; Up 200; 8.6uM; MCF7; HT_HG-U133A	CACNA1D SZT2 KIAA0232 STK24 SNX13	2.62e-04	196	66	5	6000_UP
Drug	FR139317	GPC1 PAF1 SDC1	2.64e-04	43	66	3	CID000107810
Drug	rofecoxib; Down 200; 10uM; MCF7; HG-U133A	GPC1 ATG13 CCDC85C CACNA1I CUEDC1	2.69e-04	197	66	5	256_DN
Drug	Zimelidine dihydrochloride monohydrate [61129-30-4]; Down 200; 9.8uM; HL60; HG-U133A	MYOF DNAJC8 ATG13 APOBR BHLHE40	2.69e-04	197	66	5	2012_DN
Drug	Acyclovir [59277-89-3]; Down 200; 17.8uM; MCF7; HT_HG-U133A	SSH3 CACNA1I UBXN1 SRCAP BHLHE40	2.69e-04	197	66	5	5643_DN
Drug	Fusidic acid sodium salt [751-94-0]; Up 200; 7.4uM; MCF7; HT_HG-U133A	CACNA1D SUN2 CACNA1I SRCAP BHLHE40	2.69e-04	197	66	5	5353_UP
Drug	6-Furfurylaminopurine [525-79-1]; Down 200; 18.6uM; PC3; HT_HG-U133A	GPC1 SSH3 IQSEC2 CCDC85C RUSC2	2.69e-04	197	66	5	4477_DN
Drug	5707885; Down 200; 50uM; MCF7; HT_HG-U133A	EGR4 TRO SPEG SRCAP PDZD2	2.69e-04	197	66	5	6385_DN
Drug	Alclometasone dipropionate [667634-13-2]; Down 200; 7.6uM; MCF7; HT_HG-U133A	MYOF IQSEC2 CACNA1I UBXN1 RUSC2	2.69e-04	197	66	5	6094_DN
Drug	Primidone [125-33-7]; Up 200; 18.4uM; HL60; HT_HG-U133A	GPC1 CCDC85C DGKI CACNA1I SNX13	2.69e-04	197	66	5	3065_UP
Drug	Melatonin [73-31-4]; Up 200; 17.2uM; HL60; HT_HG-U133A	COL18A1 ATG13 UBR4 CCDC85C STK24	2.75e-04	198	66	5	2431_UP
Drug	Dimenhydrinate [523-87-5]; Up 200; 8.6uM; HL60; HT_HG-U133A	IRS4 UBR4 CAPN2 CACNA1I SNX13	2.75e-04	198	66	5	2400_UP
Drug	genistein; Down 200; 10uM; PC3; HT_HG-U133A	ITPKC SUN2 SPEG CCDC85C PDZD2	2.75e-04	198	66	5	1235_DN
Drug	Guanethidine sulfate [60-02-6]; Down 200; 13.4uM; PC3; HT_HG-U133A	COL18A1 MYOF SSH3 SPEG SRCAP	2.75e-04	198	66	5	5731_DN
Drug	Myricetin [529-44-2]; Up 200; 12.6uM; MCF7; HT_HG-U133A	MYOF KIAA0232 CCDC85C BHLHE40 RUSC2	2.75e-04	198	66	5	3270_UP
Drug	arachidonyl trifluoromethyl ketone; Down 200; 10uM; MCF7; HG-U133A	COL18A1 SUN2 CACNA1I SRCAP BHLHE40	2.75e-04	198	66	5	594_DN
Drug	Kaempferol [520-18-3]; Up 200; 14uM; MCF7; HT_HG-U133A	GPC1 IRS4 CACNA1I SNX13 RUSC2	2.75e-04	198	66	5	7196_UP
Drug	Hydroquinine hydrobromide hydrate [304695-81-6]; Down 200; 9.4uM; MCF7; HT_HG-U133A	GPC1 COL18A1 CCDC85C SRCAP SDC1	2.75e-04	198	66	5	2767_DN
Drug	Pyrazinamide [ 98-96-4]; Down 200; 32.4uM; MCF7; HT_HG-U133A	ATG13 SSH3 KIAA0232 SRCAP SNX13	2.75e-04	198	66	5	4962_DN
Drug	Glimepiride [93479-97-1]; Down 200; 8.2uM; MCF7; HT_HG-U133A	COL18A1 ATG13 SSH3 CCDC85C CUEDC1	2.75e-04	198	66	5	2809_DN
Drug	Glibenclamide [10238-21-8]; Up 200; 8uM; MCF7; HT_HG-U133A	MYOF SZT2 CACNA1I STK24 RUSC2	2.75e-04	198	66	5	3163_UP
Drug	Pizotifen malate [5189-11-7]; Up 200; 9.4uM; MCF7; HT_HG-U133A	SPEG KIAA0232 SRCAP BHLHE40 SNX13	2.75e-04	198	66	5	5491_UP
Drug	Betazole hydrochloride; Up 200; 27uM; MCF7; HT_HG-U133A	CACNA1D DNAJC8 LRP3 CACNA1I SRCAP	2.75e-04	198	66	5	1690_UP
Drug	Metampicillin sodium salt [6489-61-8]; Down 200; 10.4uM; PC3; HT_HG-U133A	MYOF CAPN2 CCDC85C CUEDC1 RUSC2	2.75e-04	198	66	5	2123_DN
Drug	Propidium iodide [25535-16-4]; Down 200; 6uM; HL60; HT_HG-U133A	EGR4 SSH3 UBXN1 SNX13 RUSC2	2.75e-04	198	66	5	2541_DN
Drug	Sulfamethoxypyridazine [80-35-3]; Up 200; 14.2uM; HL60; HT_HG-U133A	GPC1 MYOF EGR4 UBR4 RAI1	2.75e-04	198	66	5	2550_UP
Drug	potassium hydroxide	COL18A1 CAPN1 CAPN2 ARAF	2.75e-04	108	66	4	CID000014797
Drug	Primidone [125-33-7]; Up 200; 18.4uM; MCF7; HT_HG-U133A	MYOF TRO CAPN2 CACNA1I RUSC2	2.81e-04	199	66	5	3402_UP
Drug	Bemegride [64-65-3]; Up 200; 25.8uM; PC3; HT_HG-U133A	SZT2 EGR4 UBXN1 NEK9 SNX13	2.81e-04	199	66	5	6668_UP
Drug	PHA-00745360 [351320-33-7]; Down 200; 1uM; PC3; HT_HG-U133A	CCDC85C CACNA1I UBXN1 SRCAP SNX13	2.81e-04	199	66	5	4562_DN
Drug	Mephentermine hemisulfate [1212-72-2]; Up 200; 9.4uM; HL60; HT_HG-U133A	MYOF SZT2 TRO STK24 RAI1	2.81e-04	199	66	5	2563_UP
Drug	S(-)Eticlopride hydrochloride [97612-24-3]; Down 200; 10.6uM; MCF7; HT_HG-U133A	GPC1 MYOF CCDC85C SNX13 RUSC2	2.81e-04	199	66	5	5695_DN
Drug	DAPH; Up 200; 10uM; PC3; HG-U133A	EGR4 SUN2 CAPN1 SRCAP NEK9	2.81e-04	199	66	5	578_UP
Drug	Ethosuximide [77-67-8]; Up 200; 28.4uM; HL60; HG-U133A	ITPKC EGR4 CAPN1 PAF1 BHLHE40	2.81e-04	199	66	5	1433_UP
Drug	Sulconazole nitrate [61318-91-0]; Down 200; 8.6uM; PC3; HT_HG-U133A	GPC1 ATG13 SPEG LRP3 RUSC2	2.81e-04	199	66	5	6652_DN
Drug	Meprylcaine hydrochloride [956-03-6]; Up 200; 14.8uM; MCF7; HT_HG-U133A	CACNA1D MYOF IRS4 TRO SRCAP	2.81e-04	199	66	5	3544_UP
Drug	Talampicillin hydrochloride [39878-70-1]; Down 200; 7.8uM; PC3; HT_HG-U133A	MYOF SSH3 SPEG SRCAP PDZD2	2.81e-04	199	66	5	7254_DN
Drug	Papaverine hydrochloride [61-25-6]; Down 200; 10.6uM; PC3; HT_HG-U133A	SZT2 SPEG LRP3 SRCAP RUSC2	2.81e-04	199	66	5	5769_DN
Drug	Benzocaine [94-09-7]; Down 200; 24.2uM; HL60; HT_HG-U133A	MYOF KLHL21 CCDC85C SRCAP STK24	2.81e-04	199	66	5	2167_DN
Drug	2-propylpentanoic acid; Down 200; 200uM; PC3; HT_HG-U133A	KLHL21 UBXN1 SRCAP NEK9 STK24	2.81e-04	199	66	5	4438_DN
Drug	Esculin Hydrate [531-75-9]; Up 200; 11.8uM; HL60; HT_HG-U133A	GPC1 UBR4 CAPN2 CACNA1I CUEDC1	2.81e-04	199	66	5	3052_UP
Drug	Leflunomide [75706-12-6]; Down 200; 14.8uM; HL60; HT_HG-U133A	MYOF EGR4 SSH3 NEK9 SNX13	2.81e-04	199	66	5	2539_DN
Drug	Propylthiouracil [51-52-5]; Up 200; 23.4uM; HL60; HT_HG-U133A	COL18A1 MYOF EGR4 CCDC85C SDC1	2.81e-04	199	66	5	2476_UP
Drug	Piperacetazine [3819-00-9]; Down 200; 9.8uM; HL60; HT_HG-U133A	DNAJC8 SSH3 STK24 SNX13 RUSC2	2.81e-04	199	66	5	6152_DN
Drug	Fluphenazine dihydrochloride [146-56-5]; Up 200; 7.8uM; MCF7; HT_HG-U133A	GPC1 IQSEC2 SRCAP NEK9 SNX13	2.81e-04	199	66	5	7234_UP
Drug	Bretylium tosylate [61-75-6]; Up 200; 9.6uM; HL60; HT_HG-U133A	IRS4 UBR4 CCDC85C CACNA1I SNX13	2.88e-04	200	66	5	3057_UP
Drug	Cinnarizine	CACNA1D CACNA1I	2.94e-04	9	66	2	DB00568
Disease	hereditary spastic paraplegia 76 (implicated_via_orthology)	CAPN8 CAPN1 CAPN2	1.02e-07	5	65	3	DOID:0110821 (implicated_via_orthology)
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CAPN8 CACNA1D CAPN1 CAPN2	1.20e-06	36	65	4	DOID:11723 (implicated_via_orthology)
Disease	intellectual disability (implicated_via_orthology)	CAPN8 IRS4 UBR4 CAPN2	2.32e-05	75	65	4	DOID:1059 (implicated_via_orthology)
Disease	Smith-Magenis syndrome	IQSEC2 RAI1	2.86e-05	4	65	2	C0795864
Disease	sciatic neuropathy (biomarker_via_orthology)	CACNA1D CAPN1 CAPN2 CACNA1I	6.90e-05	99	65	4	DOID:11446 (biomarker_via_orthology)
Disease	Polycystic kidney disease, type 2	MYC PKD2	9.96e-05	7	65	2	C2751306
Disease	hereditary spastic paraplegia (implicated_via_orthology)	CAPN8 CAPN1 CAPN2	1.18e-04	43	65	3	DOID:2476 (implicated_via_orthology)
Disease	Polycystic Kidney, Type 1 Autosomal Dominant Disease	MYC PKD2	1.33e-04	8	65	2	C0887850
Disease	Polycystic Kidney, Autosomal Dominant	MYC PKD2	1.70e-04	9	65	2	C0085413
Disease	resting heart rate	CACNA1D SUN2 SPEG UBXN1	3.33e-04	149	65	4	EFO_0004351
Disease	testosterone measurement	CACNA1D IQSEC2 ZBTB4 NUFIP2 CCDC85C DGKI DMRTA2 SRCAP SDC1 RAI1	4.50e-04	1275	65	10	EFO_0004908
Disease	gout, hyperuricemia	FAM53A PKD2	5.62e-04	16	65	2	EFO_0004274, EFO_0009104
Disease	Hemangiosarcoma	MYC COL18A1	7.15e-04	18	65	2	C0018923
Disease	Neurodevelopmental Disorders	SMC3 IQSEC2 SRCAP	1.15e-03	93	65	3	C1535926
Disease	traumatic brain injury (biomarker_via_orthology)	CAPN1 CAPN2	1.28e-03	24	65	2	DOID:0081292 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DEGYGTGGGGSSATS	AEBP2	186	Q6ZN18
GSANGQAEDGGSSTG	ARHGEF18	891	Q6ZSZ5
GSSGGSSGNTHDDFV	ATG13	431	O75143
GSDTDTDSGYGGESE	BHLHE40	236	O14503
GSSLNGFGTRSSDGD	TENT2	201	Q6PIY7
AGGSTVEGFEDFTGG	CAPN8	196	A6NHC0
SESSSDSDNSGGGGG	ANKRD17	86	O75179
SGGSTSEGFEDFTGG	CAPN1	206	P07384
GSGSENGDGESFSGS	DMRTA2	236	Q96SC8
ASGTQGASEDNSGGG	RAI1	1481	Q7Z5J4
EGGSGGFSSASSFDE	ITPKC	351	Q96DU7
SGFGQHGSGSDQSSG	FLG2	1036	Q5D862
DGTSQSTGGSADLFG	CLINT1	331	Q14677
SDFGSESGGCGDSSP	NEK9	16	Q8TD19
ASDDGSGSGSGDGCL	GPC1	481	P35052
DGGGSSVTTSGEFSN	IQSEC2	441	Q5JU85
DVGDGSSTSSAGSGG	CCDC85C	201	A6NKD9
SSSGDADGESFGGDS	KIAA0232	596	Q92628
NTSGGASAGGSDEGS	PDZD2	696	O15018
GTLGSGSESSNDGGS	PGRMC2	11	O15173
GDDSDGASGDSGSGL	COL18A1	656	P39060
GGGSSGGVYEDSSDS	CUEDC1	91	Q9NWM3
GSSSDSDGGSLGDQG	LRP3	376	O75074
ASSRGGGAFSGGEDA	LONP1	71	P36776
EGGSSGDGGEFLAST	EGR4	396	Q05215
LDDTERGSGGFGSTG	DUT	236	P33316
EGGVESGGTASDSSG	ODAD1	626	Q96M63
GGSDNDSDSGSNGGG	PAF1	476	Q8N7H5
GQSFSTDAAGSRGGS	ARAF	236	P10398
TFSGGRGFELDSGSD	KLHL21	566	Q9UJP4
VGGGYGESESSASEG	DACT3	541	Q96B18
GDNNNGSSSGGSSSG	DMKN	261	Q6E0U4
GNSGGSRGDSGSESS	DMKN	291	Q6E0U4
EEKGATGGSSSSGSG	DGKI	61	O75912
GLGSTDSGQEGSGSG	CACNA1I	566	Q9P0X4
GSGSGSSAGGEDEAD	CACNA1I	576	Q9P0X4
ESGTSGGGGSTEEAF	DNAJC8	6	O75937
SGGATTEGFEDFTGG	CAPN2	196	P17655
SGSGFSRHSGGDDEG	FAM110C	256	Q1W6H9
TEGGNHSSGKSGGFD	CACNA1D	221	Q01668
LSSEVSGSGSGNFGE	IRS4	456	O14654
TASGGTEGGSAESEG	HNRNPD	51	Q14103
SGSGGGASDTSGFSF	RUSC2	211	Q8N2Y8
HLGYDGGSSGSDSEG	SZT2	1866	Q5T011
GSDDGDGESFNGSPT	SNX13	526	Q9Y5W8
GEGSGESERGSGSQS	SMC3	1071	Q9UQE7
SGSGDGVHEGSGETS	TMEFF2	141	Q9UIK5
DAETDGQASGGSDSG	STK24	321	Q9Y6E0
SLRGDNDGGGGSFST	MYC	81	P01106
GSGDDSDNFSGSGAG	SDC1	36	P18827
GQGESEGSSSDEDGS	SRCAP	3046	Q6ZRS2
QGTDGGGGSNSSSRS	OSBPL10	6	Q9BXB5
DGDGGFSVTSGGQSR	SSH3	176	Q8TE77
TASGGEEAGTASGGD	APOBR	356	Q0VD83
GADNDGSGSESGYTT	NUFIP2	206	Q7Z417
YSQGDDDGSSSSGGS	SUN2	11	Q9UH99
ARGGDGESSEGGSSA	SPEG	2431	Q15772
SAGFSGGLSTSDGFG	TRO	1306	Q12816
GFGSGSNTSTGFTGE	TRO	1336	Q12816
FSSGGGGSVQGQSSE	SLC25A46	81	Q96AG3
SSSGEAGGGSTAAEE	ZBTB4	826	Q9P1Z0
GGSGSDSNNTGEQGA	SH2B2	386	O14492
SGSSNGAGESGGQDS	RNF185	21	Q96GF1
STEGMEGAGGNGSSN	PKD2	951	Q13563
SSEQGGLEGSGSAAG	UBXN1	66	Q04323
SSSSEDAEDEGGGGG	TXNDC11	11	Q6PKC3
EQSFSADTGGGGRES	UBR4	4971	Q5T4S7
SGGFVDSSEGSAGSG	FAM53A	191	Q6NSI3
ASGGEVEDFSSSGTG	MYOF	466	Q9NZM1