Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	-	ZBTB38 ZEB1 VEZF1 ZNF658 DPF3 ZFP91 ZNF799 ZEB2 ZNF443 ZFX ZNF44	3.11e-06	679	54	11	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZBTB38 ZEB1 VEZF1 ZNF658 DPF3 ZFP91 ZNF799 ZEB2 ZNF443 ZFX ZNF44	3.84e-06	694	54	11	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZBTB38 ZEB1 VEZF1 ZNF658 DPF3 ZFP91 ZNF799 ZEB2 ZNF443 ZFX ZNF44	1.09e-05	775	54	11	PS50157
Domain	ZINC_FINGER_C2H2_1	ZBTB38 ZEB1 VEZF1 ZNF658 DPF3 ZFP91 ZNF799 ZEB2 ZNF443 ZFX ZNF44	1.12e-05	777	54	11	PS00028
Domain	Znf_C2H2-like	ZBTB38 ZEB1 VEZF1 ZNF658 DPF3 ZFP91 ZNF799 ZEB2 ZNF443 ZFX ZNF44	1.40e-05	796	54	11	IPR015880
Domain	Znf_C2H2	ZBTB38 ZEB1 VEZF1 ZNF658 DPF3 ZFP91 ZNF799 ZEB2 ZNF443 ZFX ZNF44	1.56e-05	805	54	11	IPR007087
Domain	ZnF_C2H2	ZBTB38 ZEB1 VEZF1 ZNF658 DPF3 ZFP91 ZNF799 ZEB2 ZNF443 ZFX ZNF44	1.62e-05	808	54	11	SM00355
Domain	Di19_Zn_binding_dom	ZEB1 ZEB2	1.71e-04	7	54	2	IPR008598
Domain	zf-Di19	ZEB1 ZEB2	1.71e-04	7	54	2	PF05605
Domain	WWE	PARP11 HUWE1	5.32e-04	12	54	2	PS50918
Domain	WWE	PARP11 HUWE1	5.32e-04	12	54	2	PF02825
Domain	WWE-dom	PARP11 HUWE1	5.32e-04	12	54	2	IPR004170
Domain	zf-C2H2	ZBTB38 VEZF1 ZNF658 ZFP91 ZNF799 ZNF443 ZFX ZNF44	7.93e-04	693	54	8	PF00096
Domain	DEP	PIKFYVE DEPDC1B	1.83e-03	22	54	2	PF00610
Domain	DEP	PIKFYVE DEPDC1B	1.83e-03	22	54	2	PS50186
Domain	DEP	PIKFYVE DEPDC1B	1.83e-03	22	54	2	SM00049
Domain	DEP_dom	PIKFYVE DEPDC1B	2.00e-03	23	54	2	IPR000591
Pubmed	Human transcription factor protein interaction networks.	ZEB1 SUGP2 VEZF1 DPF3 PEG10 ZFP91 NIP7 PSMB6 RERE FAR1 MGA ZEB2	1.88e-06	1429	55	12	35140242
Pubmed	The Zeb proteins δEF1 and Sip1 may have distinct functions in lens cells following cataract surgery.	ZEB1 ZEB2	2.46e-06	2	55	2	25082886
Pubmed	ZEBs: Novel Players in Immune Cell Development and Function.	ZEB1 ZEB2	2.46e-06	2	55	2	30956067
Pubmed	Prognostic significance of ZEB1 and ZEB2 in digestive cancers: a cohort-based analysis and secondary analysis.	ZEB1 ZEB2	2.46e-06	2	55	2	28416756
Pubmed	Complete reversal of epithelial to mesenchymal transition requires inhibition of both ZEB expression and the Rho pathway.	ZEB1 ZEB2	2.46e-06	2	55	2	20025777
Pubmed	Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors.	ZEB1 ZEB2	2.46e-06	2	55	2	20424117
Pubmed	Zfhx1a and Zfhx1b mRNAs have non-overlapping expression domains during chick and mouse midgestation limb development.	ZEB1 ZEB2	2.46e-06	2	55	2	12609600
Pubmed	Expression of miRNAs and ZEB1 and ZEB2 correlates with histopathological grade in papillary urothelial tumors of the urinary bladder.	ZEB1 ZEB2	2.46e-06	2	55	2	24306957
Pubmed	Either ZEB1 or ZEB2/SIP1 can play a central role in regulating the Epstein-Barr virus latent-lytic switch in a cell-type-specific manner.	ZEB1 ZEB2	2.46e-06	2	55	2	20375168
Pubmed	Prognostic Significance of Zinc Finger E-Box-Binding Homeobox Family in Glioblastoma.	ZEB1 ZEB2	2.46e-06	2	55	2	29476046
Pubmed	Epithelial-mesenchymal transition and mesenchymal-epithelial transition via regulation of ZEB-1 and ZEB-2 expression in pancreatic cancer.	ZEB1 ZEB2	2.46e-06	2	55	2	22213144
Pubmed	TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.	ZEB1 ZEB2	2.46e-06	2	55	2	21747944
Pubmed	Functional conservation of zinc-finger homeodomain gene zfh1/SIP1 in Drosophila heart development.	ZEB1 ZEB2	2.46e-06	2	55	2	16957952
Pubmed	The adaptive antioxidant response during fasting-induced muscle atrophy is oppositely regulated by ZEB1 and ZEB2.	ZEB1 ZEB2	2.46e-06	2	55	2	37948583
Pubmed	The mesodermal and myogenic specification of hESCs depend on ZEB1 and are inhibited by ZEB2.	ZEB1 ZEB2	2.46e-06	2	55	2	37819755
Pubmed	The role of epithelial-mesenchymal transition drivers ZEB1 and ZEB2 in mediating docetaxel-resistant prostate cancer.	ZEB1 ZEB2	2.46e-06	2	55	2	28133913
Pubmed	Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity.	ZEB1 ZEB2	2.46e-06	2	55	2	34550965
Pubmed	Epithelial-mesenchymal transition transcription factor ZEB1/ZEB2 co-expression predicts poor prognosis and maintains tumor-initiating properties in head and neck cancer.	ZEB1 ZEB2	2.46e-06	2	55	2	22892238
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZEB1 CIP2A RERE HUWE1 FAR1 MGA ZEB2	4.25e-06	418	55	7	34709266
Pubmed	Vimentin, zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers: association with an aggressive tumour phenotype.	ZEB1 ZEB2	7.36e-06	3	55	2	23412770
Pubmed	A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors.	ZEB1 ZEB2	7.36e-06	3	55	2	21890822
Pubmed	TCF4 promotes colorectal cancer drug resistance and stemness via regulating ZEB1/ZEB2 expression.	ZEB1 ZEB2	7.36e-06	3	55	2	31933004
Pubmed	Down-regulation of miR-144 promotes thyroid cancer cell invasion by targeting ZEB1 and ZEB2.	ZEB1 ZEB2	7.36e-06	3	55	2	24968735
Pubmed	Src promotes EGF-induced epithelial-to-mesenchymal transition and migration in gastric cancer cells by upregulating ZEB1 and ZEB2 through AKT.	ZEB1 ZEB2	7.36e-06	3	55	2	29052277
Pubmed	Expression of miR-9 and miR-200c, ZEB1, ZEB2 and E-cadherin in Non-Small Cell Lung Cancers in Iran.	ZEB1 ZEB2	7.36e-06	3	55	2	31244281
Pubmed	miR-144-3p inhibited the growth, metastasis and epithelial-mesenchymal transition of colorectal adenocarcinoma by targeting ZEB1/2.	ZEB1 ZEB2	7.36e-06	3	55	2	34226299
Pubmed	Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta.	ZEB1 ZEB2	7.36e-06	3	55	2	17615296
Pubmed	miR-590-3p suppresses cancer cell migration, invasion and epithelial-mesenchymal transition in glioblastoma multiforme by targeting ZEB1 and ZEB2.	ZEB1 ZEB2	7.36e-06	3	55	2	26556542
Pubmed	The potential role of regulator of G-protein signaling 16 in cell motility mediated by δEF1 family proteins.	ZEB1 ZEB2	7.36e-06	3	55	2	26823172
Pubmed	A miRNA signature associated with human metastatic medullary thyroid carcinoma.	ZEB1 ZEB2	7.36e-06	3	55	2	24127332
Pubmed	The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.	ZEB1 ZEB2	7.36e-06	3	55	2	18376396
Pubmed	p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2.	ZEB1 ZEB2	7.36e-06	3	55	2	21518799
Pubmed	The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2.	ZEB1 ZEB2	7.36e-06	3	55	2	18411277
Pubmed	miR-139-5p suppresses cancer cell migration and invasion through targeting ZEB1 and ZEB2 in GBM.	ZEB1 ZEB2	7.36e-06	3	55	2	25833697
Pubmed	miR-139-5p inhibits epithelial-mesenchymal transition, migration and invasion of hepatocellular carcinoma cells by targeting ZEB1 and ZEB2.	ZEB1 ZEB2	7.36e-06	3	55	2	26022123
Pubmed	An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.	ZEB1 ZEB2	7.36e-06	3	55	2	21411626
Pubmed	BMP4 signaling mediates Zeb family in developing mouse tooth.	ZEB1 ZEB2	7.36e-06	3	55	2	22350174
Pubmed	Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2.	ZEB1 ZEB2	7.36e-06	3	55	2	24165969
Pubmed	miR-200c inhibits TGF-β-induced-EMT to restore trastuzumab sensitivity by targeting ZEB1 and ZEB2 in gastric cancer.	ZEB1 ZEB2	7.36e-06	3	55	2	29302045
Pubmed	Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis.	ZEB1 ACTN2 ZEB2	9.48e-06	26	55	3	26212757
Pubmed	Fra-1/AP-1 induces EMT in mammary epithelial cells by modulating Zeb1/2 and TGFβ expression.	ZEB1 ZEB2	1.47e-05	4	55	2	25301070
Pubmed	miR-200b regulates cell migration via Zeb family during mouse palate development.	ZEB1 ZEB2	1.47e-05	4	55	2	22261924
Pubmed	MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors.	ZEB1 ZEB2	1.47e-05	4	55	2	17360662
Pubmed	Downregulated microRNA-200a promotes EMT and tumor growth through the wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma.	ZEB1 ZEB2	1.47e-05	4	55	2	23381389
Pubmed	Ets1 and ESE1 reciprocally regulate expression of ZEB1/ZEB2, dependent on ERK1/2 activity, in breast cancer cells.	ZEB1 ZEB2	1.47e-05	4	55	2	28247944
Pubmed	Complementary expression pattern of Zfhx1 genes Sip1 and deltaEF1 in the mouse embryo and their genetic interaction revealed by compound mutants.	ZEB1 ZEB2	1.47e-05	4	55	2	16598713
Pubmed	MiR-525-5p Repressed Metastasis and Anoikis Resistance in Cervical Cancer via Blocking UBE2C/ZEB1/2 Signal Axis.	ZEB1 ZEB2	1.47e-05	4	55	2	31679088
Pubmed	miR-200b/c attenuates lipopolysaccharide-induced early pulmonary fibrosis by targeting ZEB1/2 via p38 MAPK and TGF-β/smad3 signaling pathways.	ZEB1 ZEB2	1.47e-05	4	55	2	29200203
Pubmed	miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor.	ZEB1 ZEB2	1.47e-05	4	55	2	21079000
Pubmed	The MicroRNA 29 Family Promotes Type II Cell Differentiation in Developing Lung.	ZEB1 ZEB2	1.47e-05	4	55	2	27215389
Pubmed	A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition.	ZEB1 ZEB2	2.45e-05	5	55	2	18829540
Pubmed	ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates.	ZEB1 ZEB2	2.45e-05	5	55	2	29449309
Pubmed	Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins.	ZEB1 ZEB2	2.45e-05	5	55	2	12743039
Pubmed	Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway.	ZEB1 ZEB2	2.45e-05	5	55	2	12743038
Pubmed	A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression.	ZEB1 ZEB2	2.45e-05	5	55	2	19651985
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ZEB1 SUGP2 GZMB ZFP91 RERE HUWE1 ZFX WDR44	2.81e-05	774	55	8	15302935
Pubmed	Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression.	ZEB1 ZEB2	3.67e-05	6	55	2	12161443
Pubmed	miR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5.	ZEB1 ZEB2	3.67e-05	6	55	2	22685266
Pubmed	Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin.	ZEB1 ZEB2	6.83e-05	8	55	2	16061479
Pubmed	Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors.	ZEB1 ZEB2	6.83e-05	8	55	2	25460509
Pubmed	A Zeb2-miR-200c loop controls midbrain dopaminergic neuron neurogenesis and migration.	ZEB1 ZEB2	6.83e-05	8	55	2	30271956
Pubmed	Interaction between Smad-interacting protein-1 and the corepressor C-terminal binding protein is dispensable for transcriptional repression of E-cadherin.	ZEB1 ZEB2	6.83e-05	8	55	2	12714599
Pubmed	A census of human transcription factors: function, expression and evolution.	ZBTB38 ZEB1 ETS2 RERE MGA ZEB2 ZFX ZNF44	8.60e-05	908	55	8	19274049
Pubmed	The mouse genes encoding the third pair of beta-type proteasome subunits regulated reciprocally by IFN-gamma: structural comparison, chromosomal localization, and analysis of the promoter.	PSMB6 ZFX	8.78e-05	9	55	2	9300697
Pubmed	Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression.	ZEB1 ZEB2	8.78e-05	9	55	2	24769727
Pubmed	Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin.	ZEB1 ZEB2	1.10e-04	10	55	2	34193422
Pubmed	Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.	RPS6KA2 ACTN2	1.34e-04	11	55	2	16585392
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	UBA7 ZBTB38 STXBP1 PEG10 ETS2 SH3GLB2 HUWE1 ZEB2 DALRD3	1.71e-04	1285	55	9	35914814
Pubmed	Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis.	ZEB1 ZEB2	2.21e-04	14	55	2	26324903
Pubmed	Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense.	ZFP91 FAR1	2.21e-04	14	55	2	35320721
Pubmed	Interaction network of human early embryonic transcription factors.	ZEB1 DPF3 RERE MGA ZEB2	2.34e-04	351	55	5	38297188
Pubmed	Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.	GZMB RERE	2.54e-04	15	55	2	20410501
Pubmed	Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells.	RPS6KA2 ETS2	2.54e-04	15	55	2	15509711
Pubmed	Deletion of Yy1 in mouse lung epithelium unveils molecular mechanisms governing pleuropulmonary blastoma pathogenesis.	ZEB1 ZEB2	2.54e-04	15	55	2	33158935
Pubmed	TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties.	ZEB1 ZEB2	2.90e-04	16	55	2	36418889
Pubmed	Zeb family members and boundary cap cells underlie developmental plasticity of sensory nociceptive neurons.	ZEB1 ZEB2	2.90e-04	16	55	2	25942625
Pubmed	Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2.	ZEB1 ZEB2	3.29e-04	17	55	2	31171776
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	STXBP1 GLG1 SPEF2 MEGF11	3.72e-04	214	55	4	22199357
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	SUGP2 CIP2A SH3GLB2 MGA	3.78e-04	215	55	4	35973513
Pubmed	Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice.	PRSS12 GZMB	5.06e-04	21	55	2	19592578
Pubmed	Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development.	ZEB1 ZEB2	5.06e-04	21	55	2	24161570
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	PIKFYVE CIP2A NIP7 PSMB6 SH3GLB2 RERE HUWE1 DEPDC1B WDR44	5.24e-04	1496	55	9	32877691
Pubmed	Time-sequenced transcriptomes of developing distal mouse limb buds: A comparative tissue layer analysis.	SOST FGF3	5.56e-04	22	55	2	34254395
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ZEB1 VEZF1 ZNF658 GLG1 CIP2A RERE FAR1 MGA	5.75e-04	1203	55	8	29180619
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	IFT140 MGA ZEB2	6.26e-04	105	55	3	9628581
Pubmed	Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development.	PPARGC1B ACTN2	6.63e-04	24	55	2	25348719
Pubmed	Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1.	HUWE1 ZNF44	6.63e-04	24	55	2	29871923
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	SUGP2 GLG1 NIP7 HUWE1	6.77e-04	251	55	4	28077445
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	MGA ZEB2 ZFX	6.98e-04	109	55	3	33554859
Pubmed	A single-cell time-lapse of mouse prenatal development from gastrula to birth.	ADAMDEC1 ZEB2	7.20e-04	25	55	2	38355799
Pubmed	Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.	PEG10 PSMB6 HUWE1 FAR1	7.28e-04	256	55	4	35777956
Pubmed	Maternal DNA Methylation Regulates Early Trophoblast Development.	ZEB1 ZEB2	9.04e-04	28	55	2	26812015
Pubmed	Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure.	ZEB1 ZEB2	9.04e-04	28	55	2	32005677
Pubmed	Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.	ZEB1 ZEB2	1.11e-03	31	55	2	23312518
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	ZBTB38 PEG10 SH3GLB2 ACTN2 MGA	1.13e-03	497	55	5	23414517
Pubmed	Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor.	ZEB1 ZEB2	1.18e-03	32	55	2	27806288
Pubmed	Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.	SUGP2 HUWE1	1.49e-03	36	55	2	35379950
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZBTB38 ZEB1 VEZF1 ZNF658 ZFP91 ZNF799 ZEB2 ZNF443 ZFX ZNF44	1.58e-06	718	38	10	28
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZEB1 ZEB2	4.44e-04	15	38	2	529
ToppCell	367C-Myeloid-Dendritic-cDC_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	DOK5 PPARGC1B SUGP2 CIP2A DEPDC1B	2.23e-06	171	55	5	0eea035fde32cc2a75a0d4227911edb5d54ed47e
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STXBP1 RPS6KA2 RERE HUWE1 MGA	4.24e-06	195	55	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA3 STXBP1 PEG10 RPS6KA2 AGPAT2	4.35e-06	196	55	5	83aeb96a33802949238d8a097086a1812201d1b5
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ZEB1 STXBP1 RPS6KA2 SPEF2 ETS2	4.79e-06	200	55	5	b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c02-NCAM1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	GZMB XXYLT1 ZNF799 ZNF443	2.35e-05	135	55	4	b444005987093efab3265201b3541d7941816cc2
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c03-MKI67\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	LNP1 DPF3 ZNF799 DEPDC1B	3.19e-05	146	55	4	c0e1836845c083bf9d88a620da27acbfdea9fb20
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FAP GZMB KCTD3 ZEB2	3.83e-05	153	55	4	764fb5e5fa028c137b8ea65dcd5e4ec9b22191e9
ToppCell	droplet-Liver-Hepatocytes-18m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBA7 ADAMDEC1 FAR1 ZEB2	4.13e-05	156	55	4	d72c2f5f72d269e29033f8728d924e0d4c8772c7
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	IFT140 DPF3 GZMB ZEB2	4.67e-05	161	55	4	a480107b1c7773f2081afca2657e0b7fc88a5645
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c12-MKI67-TYROBP\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PEG10 GZMB ANO7 DEPDC1B	4.90e-05	163	55	4	466c8129852a5b16cd9fcc6b79e799abc21bb21a
ToppCell	367C-Myeloid-Dendritic-cDC_proliferating_2\|367C / Donor, Lineage, Cell class and subclass (all cells)	PPARGC1B SUGP2 CIP2A DEPDC1B	5.02e-05	164	55	4	0662cd9d21608efacc336e0a582859f3b9a4951d
ToppCell	droplet-Liver-LIVER-NPC-1m-Lymphocytic-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SUGP2 VEZF1 GZMB ELAPOR1	5.14e-05	165	55	4	8c7a6f9e2ca0ce077426d3d0726e3f5a4c03b296
ToppCell	10x5'v1-week_12-13-Lymphocytic_NK-T_NK-ILC_precursor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SOST PEG10 RPS6KA2 BIVM	7.05e-05	179	55	4	bc95c3e7edc5fc6fc913b09f087d221df64c6f48
ToppCell	COPD-Epithelial-Mesothelial\|Epithelial / Disease state, Lineage and Cell class	DOK5 PPARGC1B ZEB1 ZEB2	8.52e-05	188	55	4	159d63ecc3653a7449fc6acefd6ef0464845260e
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMDEC1 DPF3 PEG10 ZEB2	8.70e-05	189	55	4	3169476f98b7385706cb618c9ad64ae83a290ef0
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA3 PEG10 RPS6KA2 AGPAT2	9.06e-05	191	55	4	6cb2c107bc674aa173b4009f320a1687a76f3979
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	GLG1 HUWE1 FAR1 ZEB2	9.06e-05	191	55	4	9454f642c3621370fa23640b631301346b300950
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA3 PEG10 RPS6KA2 AGPAT2	9.25e-05	192	55	4	5795ad6605565ce194341d08c65aae4b526dac84
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA3 PEG10 RPS6KA2 AGPAT2	9.43e-05	193	55	4	ba484fa1f290a92ae02475a4c468b4ac840c133e
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZEB1 PEG10 CIP2A DEPDC1B	9.62e-05	194	55	4	7a66bd7d4fc9c6db861cedd2487f241e406869d1
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA3 PEG10 GZMB AGPAT2	9.62e-05	194	55	4	54975e663ed4414b99b3c9a1aa6335613946470f
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA3 PEG10 RPS6KA2 AGPAT2	9.82e-05	195	55	4	6617abca0009ad3d8731f515f91ab275f9ea4c40
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA3 PEG10 RPS6KA2 AGPAT2	9.82e-05	195	55	4	fc0ae145a2118df7cbbc9ac4ca9dc12d26c087c4
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA3 PEG10 RPS6KA2 AGPAT2	9.82e-05	195	55	4	3e24570def013d5b0b1ef1d7a5ced7dfd922590b
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA3 STXBP1 PEG10 AGPAT2	9.82e-05	195	55	4	37aa6e4123d37de4de42ca68d3020f2a7686ce02
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS6KA2 RERE HUWE1 MGA	9.82e-05	195	55	4	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA3 PEG10 RPS6KA2 AGPAT2	1.00e-04	196	55	4	a6a52cafd7c9994bc3d2f68b15a1491cd96ef908
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA3 PEG10 RPS6KA2 AGPAT2	1.00e-04	196	55	4	b1abecc0aafc09ca70a5fde624f2a998c4aa3341
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA3 STXBP1 PEG10 AGPAT2	1.02e-04	197	55	4	d2a4d7e92e91bcc47a7657da2e5c8a3ad7eb08ad
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-Neuronal-Immature_CPNs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	STXBP1 PRSS12 PEG10 ELAPOR1	1.04e-04	198	55	4	4e598aab92141e7d32ec963291ddeed14a21beba
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ZEB1 STXBP1 RPS6KA2 ETS2	1.08e-04	200	55	4	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ZEB1 STXBP1 RPS6KA2 ETS2	1.08e-04	200	55	4	2d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	ZEB1 STXBP1 RPS6KA2 ETS2	1.08e-04	200	55	4	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ZEB1 STXBP1 RPS6KA2 ETS2	1.08e-04	200	55	4	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	LPS_only-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	ZEB1 STXBP1 RPS6KA2 ETS2	1.08e-04	200	55	4	81e76508c9050d533853d5fd2f3097b27613d836
ToppCell	Control_saline-Endothelial-Endothelial-Alv_Gen_Intermediate\|Control_saline / Treatment groups by lineage, cell group, cell type	ZEB1 STXBP1 RPS6KA2 ETS2	1.08e-04	200	55	4	041a34080120c9f613373c20dcc366292f558040
ToppCell	Control_saline-Endothelial-Endothelial-Gen_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	ZEB1 STXBP1 SPEF2 ETS2	1.08e-04	200	55	4	3b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCell	ILEUM-inflamed-(1)_T_cell-(1)_Highly_activated_T_cells\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CIP2A GZMB PSMB6 DEPDC1B	1.08e-04	200	55	4	d92d3bc63a56a604d7b1d49e62d4304e5e4017f2
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ZEB1 STXBP1 RPS6KA2 ETS2	1.08e-04	200	55	4	f15fffefe372005c33e31845982e2d2714ac26af
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ZEB1 STXBP1 SPEF2 ETS2	1.08e-04	200	55	4	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-CPNs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	DOK5 STXBP1 ACTN2 ZEB2	1.08e-04	200	55	4	71cbefbef4ae5bbb5f6e419914f4b3b3b5a5f9e3
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	FAP PRSS12 ACTN2 ZEB2	1.08e-04	200	55	4	bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	ZEB1 STXBP1 RPS6KA2 ETS2	1.08e-04	200	55	4	4bb609a284d4e6066f17470a1736076aa4a1f84c
Drug	Dydrogesterone [152-62-5]; Up 200; 12.8uM; MCF7; HT_HG-U133A	UBA7 ZEB1 ADAMDEC1 RPS6KA2 ELAPOR1 ACTN2 RERE	4.82e-07	198	55	7	2811_UP
Disease	Vitiligo	FAP PPARGC1B GZMB RERE	3.86e-05	101	55	4	EFO_0004208
Disease	Malignant neoplasm of breast	PPARGC1B ABCA3 ZEB1 GZMB NIP7 ELAPOR1 ETS2 FGF3 ZEB2	1.53e-04	1074	55	9	C0006142
Disease	rheumatic heart disease (biomarker_via_orthology)	ZEB1 ZEB2	2.22e-04	12	55	2	DOID:0050827 (biomarker_via_orthology)
Disease	Mammary Neoplasms, Human	PPARGC1B ZEB1 GZMB ETS2 FGF3 ZEB2	4.27e-04	525	55	6	C1257931
Disease	Mammary Carcinoma, Human	PPARGC1B ZEB1 GZMB ETS2 FGF3 ZEB2	4.27e-04	525	55	6	C4704874
Disease	Mammary Neoplasms	PPARGC1B ZEB1 GZMB ETS2 FGF3 ZEB2	4.36e-04	527	55	6	C1458155
Disease	Breast Carcinoma	PPARGC1B ZEB1 GZMB ETS2 FGF3 ZEB2	4.86e-04	538	55	6	C0678222
Disease	unipolar depression, age at onset	RPS6KA2 ETS2	2.54e-03	40	55	2	EFO_0003761, EFO_0004847
Disease	renal cell carcinoma	DPF3 ZEB2	2.80e-03	42	55	2	EFO_0000681

Protein segments in the cluster

Peptide	Gene	Start	Entry
DERAIMTYVSCFYHA	ACTN2	241	P35609
RKCESDLRHYYDSTI	GZMB	171	P10144
RRYCTSSEVAAHYCK	ABCA3	1271	Q99758
HTREKIYAICSDYAF	BIVM	61	Q86UB2
RFKSYEHCFTAAEAV	DEPDC1B	36	Q8WUY9
HTAASLFKEMCYRYR	PSMB6	111	P28072
TCRYRAFRDDDGHYS	ANO7	826	Q6IWH7
FKCTRHRISYKTAYR	MEGF11	61	A6BM72
HCFKRYGNSTRSYAV	PRSS12	676	P56730
FRCRSHVRDYRKYSE	LNP1	76	A1A4G5
VSTAYAYCNRKHIDE	FAR1	151	Q8WVX9
KEAEAFAYYRRTHTA	MGA	2416	Q8IWI9
FYKEAIEHCRSYNSR	DPF3	16	Q92784
VRPACTDKDYFYTHT	ELAPOR1	326	Q6UXG2
KRGRLYASEHYSAEC	FGF3	101	P11487
HKTSGKRYVYRFVCD	ETS2	431	P15036
RSIVFDSEYCRYHCR	PEG10	461	Q86TG7
SDERAAYFRCYHKVT	DOK5	46	Q9P104
NRLLECYFTRSFYKH	HUWE1	4121	Q7Z6Z7
YFARDAAYSSRFCKD	PARP11	236	Q9NR21
TYCRKIALSYAHSTD	PIKFYVE	211	Q9Y2I7
AVFSCLYRHAYRTEE	GLG1	591	Q92896
VSFYNMRDRSHIYTC	BTN2A1	461	Q7KYR7
EYYEFRHTQVCKASA	DALRD3	331	Q5D0E6
DCSRALSYYEKSDTH	IFT140	916	Q96RY7
YAHFAVCYRIKESSG	KCTD3	201	Q9Y597
SRAAEFYAKVALYCA	AGPAT2	21	O15120
ERAQARYEKHYSVCA	SPEF2	416	Q9C093
GHCLFYYKDSREESV	PLEKHA4	81	Q9H4M7
CFRLHNDRVYYVSEK	NIP7	36	Q9Y221
EKYGFITYRCSEHAA	PPARGC1B	941	Q86YN6
RCLHEFVKSQTTYYA	SH3GLB2	251	Q9NR46
DYVDTYHAAALRGKC	RERE	231	Q9P2R6
ARFYKHLDRGYNSCA	RERE	1131	Q9P2R6
SEYSCRELHFTRYVT	SOST	76	Q9BQB4
TAKYRAAHVFFTDSC	STXBP1	96	P61764
KDFSTSCRAHFERYL	ADAMDEC1	386	O15204
KIADYLTRYEHFSSC	CIP2A	266	Q8TCG1
CHLRKERCQYYTASF	FAP	441	Q12884
CTYCSKAFRDSYHLR	VEZF1	76	Q14119
SFQARRYVAARCTHY	UBA7	541	P41226
SYFRKECGRDLEFSH	SUGP2	101	Q8IX01
CKFVFYYHRVGTRVS	VN1R1	121	Q9GZP7
TYDGRCIFYDTEHLK	WDR44	711	Q5JSH3
SKAFSFYSSYLRHER	ZNF799	231	Q96GE5
AGRYFCAYKTTASHE	VSTM1	91	Q6UX27
HRYSYCKREAEERDS	ZEB1	981	P37275
YLSDEHGKCRKSFYR	ZNF658	381	Q5TYW1
SKAFSFYSSYLRHER	ZNF443	231	Q9Y2A4
YCEYSTTDASGFKRH	ZFX	751	P17010
DYICEYCARAFKSSH	ZFP91	371	Q96JP5
HYCNKVFALAEYRTR	ZBTB38	491	Q8NAP3
CSYTFAYRTQLERHM	ZEB2	246	O60315
HRYSYCKREAEEREA	ZEB2	1076	O60315
CSKAFPDYSSYLRHE	ZNF44	306	P15621
RDHGYSDVFEAYFRC	XXYLT1	361	Q8NBI6
DHDKRAYSFCGTIEY	RPS6KA2	211	Q15349