Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR51A4 OR51A2 XCR1 FLT1 PDGFRB OR2T2 TSHR ITGA2 RET RYK OR1D2 TLR10 ZACN NPY4R2 OR6B3 CSF1R NPY4R P2RY4 MRGPRX1 GPR45 GABRA4	5.41e-06	1353	104	21	GO:0004888
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	FLT1 PDGFRB RET RYK CSF1R	2.24e-05	65	104	5	GO:0004714
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	FLT1 PDGFRB RET RYK CSF1R	8.20e-05	85	104	5	GO:0019199
GeneOntologyMolecularFunction	pancreatic polypeptide receptor activity	NPY4R2 NPY4R	1.60e-04	4	104	2	GO:0001602
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR51A4 OR51A2 XCR1 PDGFRB OR2T2 TSHR OR1D2 NPY4R2 OR6B3 NPY4R P2RY4 MRGPRX1 GPR45	6.77e-04	884	104	13	GO:0004930
GeneOntologyMolecularFunction	neuropeptide binding	NPY4R2 NPY4R MRGPRX1	9.38e-04	37	104	3	GO:0042923
GeneOntologyMolecularFunction	protein tyrosine kinase activity	FLT1 PDGFRB RET RYK CSF1R	9.74e-04	145	104	5	GO:0004713
MousePheno	abnormal coping response	WFS1 TSC2 ADAD2 CSF1R RNF180	2.06e-05	66	71	5	MP:0003062
MousePheno	abnormal social investigation	TMPRSS9 HIVEP2 WFS1 TSC2 NLGN3 LRRC7 RNF180	2.50e-05	171	71	7	MP:0001360
Domain	Tyr_kinase_rcpt_3_CS	FLT1 PDGFRB CSF1R	8.18e-06	8	100	3	IPR001824
Domain	RECEPTOR_TYR_KIN_III	FLT1 PDGFRB CSF1R	8.18e-06	8	100	3	PS00240
Domain	NPY4_rcpt	NPY4R2 NPY4R	2.84e-05	2	100	2	IPR001933
Domain	-	SAMD4B SAMD4A	2.84e-05	2	100	2	1.25.40.170
Domain	PHAT_dom	SAMD4B SAMD4A	2.84e-05	2	100	2	IPR015327
Domain	TyrKc	FLT1 PDGFRB RET RYK CSF1R	1.10e-04	88	100	5	SM00219
Domain	Tyr_kinase_cat_dom	FLT1 PDGFRB RET RYK CSF1R	1.10e-04	88	100	5	IPR020635
Domain	PROTEIN_KINASE_TYR	FLT1 PDGFRB RET RYK CSF1R	1.74e-04	97	100	5	PS00109
Domain	Tyr_kinase_AS	FLT1 PDGFRB RET RYK CSF1R	1.74e-04	97	100	5	IPR008266
Domain	GPCR_Rhodpsn_7TM	OR51A4 OR51A2 XCR1 OR2T2 TSHR OR1D2 NPY4R2 OR6B3 NPY4R P2RY4 MRGPRX1 GPR45	2.41e-04	670	100	12	IPR017452
Domain	7tm_1	OR51A4 OR51A2 XCR1 OR2T2 TSHR OR1D2 NPY4R2 OR6B3 NPY4R P2RY4 MRGPRX1 GPR45	2.65e-04	677	100	12	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR51A4 OR51A2 XCR1 OR2T2 TSHR OR1D2 NPY4R2 OR6B3 NPY4R P2RY4 MRGPRX1 GPR45	2.95e-04	685	100	12	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR51A4 OR51A2 XCR1 OR2T2 TSHR OR1D2 NPY4R2 OR6B3 NPY4R P2RY4 MRGPRX1 GPR45	3.20e-04	691	100	12	PS50262
Domain	GPCR_Rhodpsn	OR51A4 OR51A2 XCR1 OR2T2 TSHR OR1D2 NPY4R2 OR6B3 NPY4R P2RY4 MRGPRX1 GPR45	3.24e-04	692	100	12	IPR000276
Domain	Cadherin	DCHS2 PCDHGC5 RET FAT2 CDH15	3.54e-04	113	100	5	PF00028
Domain	CADHERIN_2	DCHS2 PCDHGC5 RET FAT2 CDH15	3.68e-04	114	100	5	PS50268
Domain	-	DCHS2 PCDHGC5 RET FAT2 CDH15	3.68e-04	114	100	5	2.60.40.60
Domain	CA	DCHS2 PCDHGC5 RET FAT2 CDH15	3.83e-04	115	100	5	SM00112
Domain	Cadherin-like	DCHS2 PCDHGC5 RET FAT2 CDH15	3.99e-04	116	100	5	IPR015919
Domain	Tyr_kinase_CSF1/PDGF_rcpt	PDGFRB CSF1R	4.20e-04	6	100	2	IPR016243
Domain	Cadherin	DCHS2 PCDHGC5 RET FAT2 CDH15	4.31e-04	118	100	5	IPR002126
Domain	SAM_1	SAMD4B ZCCHC14 ARAP2 SAMD4A	4.85e-04	68	100	4	PF00536
Domain	Pkinase_Tyr	FLT1 PDGFRB RET RYK CSF1R	6.48e-04	129	100	5	PF07714
Domain	DHC_N1	DNAH10 DYNC1H1	7.78e-04	8	100	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH10 DYNC1H1	7.78e-04	8	100	2	IPR013594
Domain	Ser-Thr/Tyr_kinase_cat_dom	FLT1 PDGFRB RET RYK CSF1R	8.79e-04	138	100	5	IPR001245
Domain	NPY_rcpt	NPY4R2 NPY4R	9.97e-04	9	100	2	IPR000611
Domain	SAM	SAMD4B ZCCHC14 ARAP2 SAMD4A	1.83e-03	97	100	4	IPR001660
Domain	Dynein_heavy_chain_D4_dom	DNAH10 DYNC1H1	2.48e-03	14	100	2	IPR024317
Domain	Dynein_HC_stalk	DNAH10 DYNC1H1	2.48e-03	14	100	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH10 DYNC1H1	2.48e-03	14	100	2	IPR013602
Domain	DHC_N2	DNAH10 DYNC1H1	2.48e-03	14	100	2	PF08393
Domain	MT	DNAH10 DYNC1H1	2.48e-03	14	100	2	PF12777
Domain	AAA_8	DNAH10 DYNC1H1	2.48e-03	14	100	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH10 DYNC1H1	2.48e-03	14	100	2	IPR011704
Domain	AAA_5	DNAH10 DYNC1H1	2.48e-03	14	100	2	PF07728
Domain	-	SAMD4B ZCCHC14 ARAP2 SAMD4A	2.53e-03	106	100	4	1.10.150.50
Domain	Cadherin_CS	DCHS2 PCDHGC5 FAT2 CDH15	2.80e-03	109	100	4	IPR020894
Domain	DHC_fam	DNAH10 DYNC1H1	2.85e-03	15	100	2	IPR026983
Domain	Dynein_heavy_dom	DNAH10 DYNC1H1	2.85e-03	15	100	2	IPR004273
Domain	Dynein_heavy	DNAH10 DYNC1H1	2.85e-03	15	100	2	PF03028
Domain	CADHERIN_1	DCHS2 PCDHGC5 FAT2 CDH15	3.19e-03	113	100	4	PS00232
Domain	SAM/pointed	SAMD4B ZCCHC14 ARAP2 SAMD4A	3.61e-03	117	100	4	IPR013761
Domain	Cyclin_C	CCNF CCNL1	3.66e-03	17	100	2	PF02984
Domain	Cyclin_C-dom	CCNF CCNL1	3.66e-03	17	100	2	IPR004367
Domain	Cyclin_C	CCNF CCNL1	3.66e-03	17	100	2	SM01332
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_UBIQUITINATION_OF_RTK_BY_CBL	FLT1 PDGFRB CBL CSF1R	7.71e-06	25	73	4	M47934
Pubmed	M-CSF induces the stable interaction of cFms with alphaVbeta3 integrin in osteoclasts.	CBL PHKA2 CSF1R	1.48e-06	8	105	3	16600665
Pubmed	The protein tyrosine kinase family of the human genome.	FLT1 PDGFRB RET RYK CSF1R	5.49e-06	83	105	5	11114734
Pubmed	c-Cbl associates directly with the C-terminal tail of the receptor for the macrophage colony-stimulating factor, c-Fms, and down-modulates this receptor but not the viral oncogene v-Fms.	CBL CSF1R	9.03e-06	2	105	2	11847211
Pubmed	The Novel Pathogenesis of Retinopathy Mediated by Multiple RTK Signals is Uncovered in Newly Developed Mouse Model.	FLT1 PDGFRB	9.03e-06	2	105	2	29724654
Pubmed	Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules.	SAMD4B SAMD4A	9.03e-06	2	105	2	16221671
Pubmed	Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.	GALNT3 GALNT6	9.03e-06	2	105	2	31932717
Pubmed	PP1 inhibitor induces degradation of RETMEN2A and RETMEN2B oncoproteins through proteosomal targeting.	RET CBL	9.03e-06	2	105	2	12727845
Pubmed	The polypeptide GALNT6 Displays Redundant Functions upon Suppression of its Closest Homolog GALNT3 in Mediating Aberrant O-Glycosylation, Associated with Ovarian Cancer Progression.	GALNT3 GALNT6	9.03e-06	2	105	2	31071912
Pubmed	Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes.	PDGFRB CSF1R	9.03e-06	2	105	2	2846185
Pubmed	CSF1R copy number changes, point mutations, and RNA and protein overexpression in renal cell carcinomas.	PDGFRB CSF1R	9.03e-06	2	105	2	19377443
Pubmed	Combined vascular endothelial growth factor and platelet-derived growth factor inhibition in rat cardiac allografts: beneficial effects on inflammation and smooth muscle cell proliferation.	FLT1 PDGFRB	9.03e-06	2	105	2	15665766
Pubmed	Association of Cbl with Fms and p85 in response to macrophage colony-stimulating factor.	CBL CSF1R	9.03e-06	2	105	2	10648820
Pubmed	Genes encoding the platelet-derived growth factor (PDGF) receptor and colony-stimulating factor 1 (CSF-1) receptor are physically associated in mice as in humans.	PDGFRB CSF1R	9.03e-06	2	105	2	1660841
Pubmed	TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase.	TSC2 HERC1	2.70e-05	3	105	2	16464865
Pubmed	Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation.	PDGFRB CBL	2.70e-05	3	105	2	17620338
Pubmed	The Src-like adaptor protein regulates PDGF-induced actin dorsal ruffles in a c-Cbl-dependent manner.	PDGFRB CBL	2.70e-05	3	105	2	18193084
Pubmed	C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus.	CBL CSF1R	2.70e-05	3	105	2	11850825
Pubmed	VEGF receptor 1 signaling is essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient mice.	FLT1 CSF1R	2.70e-05	3	105	2	16172397
Pubmed	Flt-1 expression influences apoptotic susceptibility of vascular smooth muscle cells through the NF-kappaB/IAP-1 pathway.	FLT1 BIRC2	2.70e-05	3	105	2	19720604
Pubmed	Catalytically inactive SHIP2 inhibits proliferation by attenuating PDGF signaling in 3T3-L1 preadipocytes.	PDGFRB CBL	2.70e-05	3	105	2	18814181
Pubmed	Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain.	PDGFRB CBL	2.70e-05	3	105	2	10347229
Pubmed	Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms.	RET CSF1R	2.70e-05	3	105	2	31768065
Pubmed	A new homozygous HERC1 gain-of-function variant in MDFPMR syndrome leads to mTORC1 hyperactivation and reduced autophagy during cell catabolism.	TSC2 HERC1	2.70e-05	3	105	2	32921582
Pubmed	The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1).	FLT1 CBL	2.70e-05	3	105	2	15001553
Pubmed	The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.	PDGFRB CBL	2.70e-05	3	105	2	10514377
Pubmed	Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1.	GFI1 CSF1R	2.70e-05	3	105	2	18328744
Pubmed	Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta).	PDGFRB CBL	2.70e-05	3	105	2	15753096
Pubmed	Alix facilitates the interaction between c-Cbl and platelet-derived growth factor beta-receptor and thereby modulates receptor down-regulation.	PDGFRB CBL	2.70e-05	3	105	2	17082185
Pubmed	Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.	NPY4R2 NPY4R	2.70e-05	3	105	2	8643460
Pubmed	The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling.	PDGFRB CBL	2.70e-05	3	105	2	27048651
Pubmed	The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by controlling CSF-1R import into macropinosomes.	CBL CSF1R	2.70e-05	3	105	2	38170572
Pubmed	Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells.	FLT1 PDGFRB BIRC2	3.42e-05	21	105	3	21593423
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ZNF704 HIVEP2 SAMD4B PATL1 YJEFN3 SHROOM2 ALX4 PCNX2 NLGN3 INTS2 SEMA3B LRRC7 GREB1 VPS13B CDH15	4.13e-05	1489	105	15	28611215
Pubmed	Association of a determinant on mouse chromosome 18 with experimental severe Plasmodium berghei malaria.	PDGFRB CSF1R	5.40e-05	4	105	2	11796577
Pubmed	SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors.	PDGFRB CSF1R	5.40e-05	4	105	2	1372092
Pubmed	APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis.	PDGFRB CBL	5.40e-05	4	105	2	9989826
Pubmed	Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein.	FLT1 CBL	5.40e-05	4	105	2	17962812
Pubmed	Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34.	CSF1R TNR	5.40e-05	4	105	2	23744080
Pubmed	Association between phosphatidylinositol-3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophages.	CBL CSF1R	5.40e-05	4	105	2	8947469
Pubmed	Enigma prevents Cbl-c-mediated ubiquitination and degradation of RETMEN2A.	RET CBL	5.40e-05	4	105	2	24466333
Pubmed	A novel anesthesia regime enables neurofunctional studies and imaging genetics across mouse strains.	TSC2 NLGN3	5.40e-05	4	105	2	27080031
Pubmed	Aberrant expression of HOXA9, DEK, CBL and CSF1R in acute myeloid leukemia.	CBL CSF1R	5.40e-05	4	105	2	14738146
Pubmed	Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.	NPY4R2 NPY4R	5.40e-05	4	105	2	7592911
Pubmed	Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.	FLT1 PDGFRB CSF1R	8.29e-05	28	105	3	18593464
Pubmed	The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization.	GALNT3 GALNT6	8.97e-05	5	105	2	12506059
Pubmed	Differential recruitment of E3 ubiquitin ligase complexes regulates RET isoform internalization.	RET CBL	8.97e-05	5	105	2	28794017
Pubmed	Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.	NPY4R2 NPY4R	8.97e-05	5	105	2	7493937
Pubmed	Type I collagen synergistically enhances PDGF-induced smooth muscle cell proliferation through pp60src-dependent crosstalk between the alpha2beta1 integrin and PDGFbeta receptor.	PDGFRB ITGA2	8.97e-05	5	105	2	15522237
Pubmed	N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain.	FLT1 CBL	8.97e-05	5	105	2	25387128
Pubmed	The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation.	CBL CSF1R	8.97e-05	5	105	2	17353186
Pubmed	Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism.	FLT1 ITGA2	8.97e-05	5	105	2	21596751
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	FLT1 PDGFRB TSC2 ITGA2 RET RB1CC1 TLR10	9.80e-05	351	105	7	20453000
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	PATL1 SHROOM2 NLGN3 PSME4 INTS2 PGAP1 HPS1 CCNL1 NFRKB HERC1 VPS13B ZNF445	1.08e-04	1084	105	12	11544199
Pubmed	Murine txk: a protein tyrosine kinase gene regulated by T cell activation.	PDGFRB RYK CSF1R	1.24e-04	32	105	3	7542761
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	SAMD4B TSC2 CBL SHROOM2 DYNC1H1 SAMD4A	1.29e-04	255	105	6	15324660
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HEXA HIVEP2 TSC2 TBC1D17 KIAA2013 PCNX2 ZCCHC14 ARHGEF40 PSME4 DISP2 HERC1 DYNC1H1	1.29e-04	1105	105	12	35748872
Pubmed	M-CSF regulates the cytoskeleton via recruitment of a multimeric signaling complex to c-Fms Tyr-559/697/721.	CBL CSF1R	1.34e-04	6	105	2	17420256
Pubmed	A new chemical probe for quantitative proteomic profiling of fibroblast growth factor receptor and its inhibitors.	PDGFRB RET	1.34e-04	6	105	2	24184958
Pubmed	The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species.	CSF1R CDH15	1.34e-04	6	105	2	1427864
Pubmed	CSF-1 stimulated multiubiquitination of the CSF-1 receptor and of Cbl follows their tyrosine phosphorylation and association with other signaling proteins.	CBL CSF1R	1.34e-04	6	105	2	10025673
Pubmed	Numb promotes an increase in skeletal muscle progenitor cells in the embryonic somite.	ALX4 CDH15	1.34e-04	6	105	2	19785007
Pubmed	Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways.	CBL CSF1R	1.34e-04	6	105	2	7782294
Pubmed	Distinct turnover of alternatively spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase.	RET CBL	1.34e-04	6	105	2	15677445
Pubmed	Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.	FLT1 VSTM2B IGSF10 CSF1R SEMA3B	1.37e-04	162	105	5	25826454
Pubmed	Control of HIF-1{alpha} and vascular signaling in fetal lung involves cross talk between mTORC1 and the FGF-10/FGFR2b/Spry2 airway branching periodicity clock.	TSC2 CBL	1.88e-04	7	105	2	20622121
Pubmed	Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.	DCHS2 FAT2	1.88e-04	7	105	2	16059920
Pubmed	Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol.	PIGS PGAP1	1.88e-04	7	105	2	1846368
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZCCHC14 CCAR2 DISP2 LRRC7 DYNC1H1 VPS13B ARAP2	2.43e-04	407	105	7	12693553
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	PDGFRB PKD1L1 QRICH1 PSME4	2.46e-04	100	105	4	25807483
Pubmed	Abl family kinases regulate endothelial barrier function in vitro and in mice.	PDGFRB CSF1R	2.50e-04	8	105	2	24367707
Pubmed	CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2.	CBL CSF1R	2.50e-04	8	105	2	9178909
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	HEXA GALNT3 WFS1 PIGS KIAA1549 TSC2 ITGA2 KIAA2013 DMXL1 IGSF10 PGAP1 SEMA3B	2.77e-04	1201	105	12	35696571
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CDK18 HIVEP2 SAMD4B TSC2 PTPN21 CBL ZCCHC14 RNF180 ARAP2 SAMD4A	2.85e-04	861	105	10	36931259
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ZCCHC14 GREB1 VPS13B ARAP2	2.97e-04	105	105	4	9628581
Pubmed	CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.	PDGFRB CBL	3.21e-04	9	105	2	12177062
Pubmed	The diminished expression of proangiogenic growth factors and their receptors in gastric ulcers of cirrhotic patients.	FLT1 PDGFRB	3.21e-04	9	105	2	23620752
Pubmed	Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23.	RET CSF1R	3.21e-04	9	105	2	1611909
Pubmed	A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome.	FAT2 CSF1R	3.21e-04	9	105	2	19966810
Pubmed	Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates.	FLT1 CBL	4.00e-04	10	105	2	18273061
Pubmed	Accelerated coronary angiogenesis by vegfr1-knockout endocardial cells.	FLT1 DEPP1	4.00e-04	10	105	2	23894673
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	CDK18 SAMD4B KIAA1549 TSC2 CBL NUP160 SAMD4A	4.21e-04	446	105	7	24255178
Pubmed	Purification and identification of protein-tyrosine kinase-binding proteins using synthetic phosphopeptides as affinity reagents.	CBL CSF1R	4.88e-04	11	105	2	15215307
Pubmed	An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates.	RET MRGPRX1	4.88e-04	11	105	2	21151121
Pubmed	Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.	PDGFRB CBL	4.88e-04	11	105	2	16135792
Pubmed	Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways.	TSC2 RB1CC1	4.88e-04	11	105	2	17015619
Pubmed	MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy.	TSC2 RB1CC1	4.88e-04	11	105	2	28059666
Pubmed	A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis.	SAMD4B SAMD4A	4.88e-04	11	105	2	26609159
Pubmed	Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.	FLT1 PDGFRB	4.88e-04	11	105	2	17981115
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	RB1CC1 MORC4 WDR43 KCTD6 INTS2 CCAR2 NUP160	5.67e-04	469	105	7	27634302
Pubmed	USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation.	KCTD6 DYNC1H1	5.84e-04	12	105	2	29293652
Pubmed	YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis.	RET TNR	5.84e-04	12	105	2	10101119
Pubmed	The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-β signaling.	RET RB1CC1	5.84e-04	12	105	2	23537899
Pubmed	Advancing the understanding of autism disease mechanisms through genetics.	TSC2 NLGN3	6.89e-04	13	105	2	27050589
Pubmed	A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles.	PDGFRB TSC2	6.89e-04	13	105	2	19357198
Pubmed	ULK1 inhibits the kinase activity of mTORC1 and cell proliferation.	TSC2 RB1CC1	6.89e-04	13	105	2	21795849
Pubmed	gdnf activates midline repulsion by Semaphorin3B via NCAM during commissural axon guidance.	RET SEMA3B	6.89e-04	13	105	2	22998873
Pubmed	Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors.	GART TSC2 RB1CC1 KIAA2013 TULP2 NUP160	7.92e-04	359	105	6	35559673
Pubmed	Pigmentation-related genes and their implication in malignant melanoma susceptibility.	HPS1 VPS13B	8.02e-04	14	105	2	19320733
Pubmed	CIN85 associates with TNF receptor 1 via Src and modulates TNF-alpha-induced apoptosis.	BIRC2 CBL	8.02e-04	14	105	2	15707590
Pubmed	A multipoint genetic linkage map of mouse chromosome 18.	PDGFRB CSF1R	8.02e-04	14	105	2	1354640
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	FLT1 PDGFRB RET RYK CSF1R	4.79e-07	40	71	5	321
GeneFamily	Cadherin related	DCHS2 RET FAT2	3.79e-05	17	71	3	24
GeneFamily	Sterile alpha motif domain containing	SAMD4B ZCCHC14 ARAP2 SAMD4A	3.97e-04	88	71	4	760
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT3 GALNT6	2.76e-03	20	71	2	433
GeneFamily	Glycosyl transferases group 1 domain containing\|Phosphatidylinositol glycan anchor biosynthesis	PIGS PIGA	3.04e-03	21	71	2	680
GeneFamily	Cyclins	CCNF CCNL1	5.38e-03	28	71	2	473
GeneFamily	Immunoglobulin like domain containing	FLT1 PDGFRB CSF1R SEMA3B	7.01e-03	193	71	4	594
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT3 KIAA1549 VSTM2B NLGN3 CCAR2 RNF180 TNR	3.00e-07	188	104	7	7471c194276161422326647f09022e94f3d1640c
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT3 KIAA1549 VSTM2B NLGN3 CCAR2 RNF180 TNR	3.00e-07	188	104	7	053c251d3ddbeb866f34565aefca4535517b4387
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT3 KIAA1549 VSTM2B NLGN3 CCAR2 RNF180 TNR	3.22e-07	190	104	7	9b825b2586c7b173ff27fcf2abc5860faf50984a
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT3 KIAA1549 VSTM2B NLGN3 CCAR2 RNF180 TNR	3.22e-07	190	104	7	d146af1926474328a7c822bc140c4dda66e1bbfb
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT3 KIAA1549 VSTM2B NLGN3 CCAR2 RNF180 TNR	3.34e-07	191	104	7	ece87127f85939e61b1048d968ed96f0e87c3a79
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT3 KIAA1549 VSTM2B NLGN3 CCAR2 RNF180 TNR	3.34e-07	191	104	7	478e8341ee03b05501e2233e02cef5f97492c95d
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF704 CDK18 SLC4A8 PDGFRB INTS2 SLC49A4	2.68e-06	167	104	6	b0eb7a40491dd2432f5282f578ce569df86d21a7
ToppCell	LPS-antiTNF-Myeloid-Dendritic_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	XCR1 TLR10 FAT2 CSF1R JCHAIN CDH15	2.98e-06	170	104	6	3cbeea6bfa500928c413b1c6129f6dedc769cd1e
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT3 VSTM2B NLGN3 CCAR2 RNF180 TNR	4.69e-06	184	104	6	278a7ed764c326450cb70e69ed2175980eaf5fe0
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT3 VSTM2B NLGN3 CCAR2 RNF180 TNR	4.69e-06	184	104	6	8d86e125257ff1d3af8d90577a8b3f0321eca21c
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CDK18 SLC4A8 DNAH10 BIRC2 PHKA2	2.39e-05	146	104	5	cffa91d76606f74553d81150adbb23b003746316
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	CDK18 SLC4A8 DNAH10 BIRC2 PHKA2	2.99e-05	153	104	5	e7d20c88466ff81db613869cf7a6a4bb95fd6c2f
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Parm1-Excitatory_Neuron.Slc17a7.Parm1.Fos_(Deep_layer_pyramidal_cells--layer_5_(IEG))\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	DCHS2 GALNT3 JCHAIN CDH15	3.20e-05	77	104	4	4879a1a72b950dadb78bc0312be75f1a32b935d5
ToppCell	droplet-Fat-Mat-18m-Myeloid-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZMYND15 HEXA XCR1 TMPRSS9 CSF1R	3.81e-05	161	104	5	8c62ae3fcf304db0f71633e328ceba81a70f03c4
ToppCell	LPS-antiTNF-Myeloid-Dendritic_cells-mDC\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZMYND15 XCR1 TLR10 FAT2 CSF1R	4.67e-05	168	104	5	2dca1c4a33b6da9357fa3b2a523af19baab1c21c
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_A\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC4A8 KIAA1549 RET GALNT6 CDH15	4.80e-05	169	104	5	606aa4ff25380d9470ec116ca86cd20f8b19587a
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_A-Branch_A1_(iMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC4A8 KIAA1549 RET GALNT6 CDH15	4.80e-05	169	104	5	052aae2af5446a0de071d5dda5381b0b9a0ed54d
ToppCell	severe_influenza-Plasmablast\|severe_influenza / disease group, cell group and cell class (v2)	XCR1 KIAA1549 CCDC168 IGSF10 JCHAIN	5.51e-05	174	104	5	8c6c4d794373e774ecb3382cb7163b4246b98780
ToppCell	AT1-AT2_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	WFS1 ITGA2 MORC4 SEMA3B SAMD4A	5.66e-05	175	104	5	9a95ab5c361ebaa8747983c5a0d69025682a19ad
ToppCell	AT1_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	WFS1 ITGA2 PTPN21 SEMA3B SAMD4A	5.82e-05	176	104	5	458720776b0151cd55acc352d509599cb62f0ca8
ToppCell	LPS-IL1RA-Myeloid-Dendritic_cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	XCR1 TLR10 CSF1R JCHAIN CDH15	5.82e-05	176	104	5	f3bbe8c1a8d132705eac360cf531261271d84588
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CDK18 PDGFRB VSTM2B ALX4 SAMD4A	6.30e-05	179	104	5	f5bb4d3a27d56698473219970e764084096cc582
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CDK18 PDGFRB VSTM2B ALX4 SAMD4A	6.30e-05	179	104	5	fa03ec3cc0132f977b4cb28e7b23789732375183
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDK18 PDGFRB VSTM2B ALX4 SAMD4A	6.47e-05	180	104	5	f6a05b3751b01e74b2de8440801b0eb2e723c199
ToppCell	droplet-Lung-nan-18m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDK18 PDGFRB VSTM2B ALX4 SAMD4A	6.47e-05	180	104	5	dfc75ae4395ff46fbec2c54915d98ead5a1ba1a1
ToppCell	E16.5-samps-Endothelial-Immature_fetal_endothelial-Intermediate_Endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	FLT1 DEPP1 ITGA2 SHROOM2 ARAP2	6.82e-05	182	104	5	fec1caf867b1dc87b24504d895ee1a27df78062e
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D122\|Adult / Lineage, Cell type, age group and donor	WFS1 PTPN21 SEMA3B ARAP2 SAMD4A	7.18e-05	184	104	5	561592edc3083fad41b91811151b442207c65dd9
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1\|Children_(3_yrs) / Lineage, Cell type, age group and donor	WFS1 PTPN21 SEMA3B ARAP2 SAMD4A	7.37e-05	185	104	5	1c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZMYND15 SLC4A8 BIRC2 ARHGEF40 RNF180	7.37e-05	185	104	5	19fa853f6f746ccf232a343b3c9c7a5e55800409
ToppCell	droplet-Heart-nan-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC4A8 PDGFRB VSTM2B JCHAIN CCAR2	7.75e-05	187	104	5	59313a47a6012b2413d7d3673bb05fb7e49fd88f
ToppCell	droplet-Heart-nan-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC4A8 PDGFRB VSTM2B JCHAIN CCAR2	7.75e-05	187	104	5	2591fe1552cd10925ad1d8d1f062a057ce6bdad9
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	WFS1 PTPN21 SEMA3B ARAP2 SAMD4A	7.75e-05	187	104	5	d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1\|Adult / Lineage, Cell type, age group and donor	WFS1 PTPN21 SEMA3B ARAP2 SAMD4A	7.75e-05	187	104	5	77f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	RB1CC1 CCNL1 HERC1 DYNC1H1 ARAP2	7.95e-05	188	104	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	E16.5-samps-Endothelial-Immature_fetal_endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	FLT1 DEPP1 ITGA2 SHROOM2 ARAP2	8.56e-05	191	104	5	44c596984c6196f6014e0e405dbe5560841e54ff
ToppCell	E16.5-samps-Endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	FLT1 DEPP1 ITGA2 SHROOM2 ARAP2	8.56e-05	191	104	5	e7521d4d24f016d4e531cd492a7a69604f0c9e6f
ToppCell	ASK454-Epithelial-Secretory\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	CCDC125 GALNT3 MDH2 CCAR2 CDH15	8.56e-05	191	104	5	c63c781e7e93265e591cf494cb4ce8ed797c24fb
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	HIVEP2 SAMD4B PSME4 CCNL1 SAMD4A	8.99e-05	193	104	5	dbf0fe496254320c894568c31e5f9ce63707d1b5
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	GALNT3 PDGFRB MDH2 GFI1 PSME4	8.99e-05	193	104	5	778fcf8448e81fe18972d97ea8a30ab036d16fe5
ToppCell	facs-Pancreas-Endocrine-18m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXA WFS1 SAMD4B DISP2 GPR45	9.44e-05	195	104	5	bc8a39fdf70faa187ba40c46fb9674a604795c9e
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WFS1 SAMD4B RET DISP2 GPR45	9.44e-05	195	104	5	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHGC5 PCNX2 CCAR2 LRRC7 GABRA4	9.44e-05	195	104	5	ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCell	ILEUM-inflamed-(7)_Endothelial_cell-(7)_CD36+_endothelial_cells\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ZNF704 FLT1 PDGFRB CBL JCHAIN	9.90e-05	197	104	5	66339b5aae3952f5c484c9dcb0cfb4fbd828d4cb
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WFS1 PTPN21 SEMA3B ARAP2 SAMD4A	9.90e-05	197	104	5	8d5097898dd01cedb04cb694cb480c931e08462c
ToppCell	LPS_IL1RA-Hematopoietic_Myeloid-Dendritic_cells\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	XCR1 TLR10 CSF1R TEX47 CDH15	1.01e-04	198	104	5	ba3b97bb3e1533df758e845bde7d82eb1525b057
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PGAP1 CCNL1 HERC1 VPS13B ARAP2	1.04e-04	199	104	5	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CCDC125 ZNF704 GALNT3 KIAA1549 GALNT6	1.06e-04	200	104	5	c450a15e21fa72d071ed6e3b9f22de557a0f3cea
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC4A8 GALNT3 KIAA1549 MORC4 GALNT6	1.06e-04	200	104	5	ed093626a9cac7531a2bf02f6e345c5e84b8c060
Drug	Sunitinib	FLT1 PDGFRB CSF1R	5.10e-06	8	104	3	DB01268
Drug	Imatinib	PDGFRB RET CSF1R	5.10e-06	8	104	3	DB00619
Drug	FF 3	FLT1 PDGFRB CSF1R	1.09e-05	10	104	3	CID009543502
Disease	Transitional cell carcinoma of bladder	FLT1 RET	6.26e-05	4	96	2	C0279680
Disease	myeloproliferative neoplasm (implicated_via_orthology)	PDGFRB CBL	6.26e-05	4	96	2	DOID:2226 (implicated_via_orthology)
Disease	mood instability measurement	HIVEP2 QRICH1 ZCCHC14 EYS NUP160	6.33e-05	128	96	5	EFO_0008475
Disease	diabetes mellitus (is_implicated_in)	WFS1 ITGA2 CSF1R	1.15e-04	29	96	3	DOID:9351 (is_implicated_in)
Disease	platelet-derived growth factor receptor beta measurement	PDGFRB CSF1R	1.56e-04	6	96	2	EFO_0008265
Disease	Malignant neoplasm of breast	FLT1 PIGS DEPP1 BIRC2 RB1CC1 SHROOM2 ZCCHC14 CSF1R LRRC7 VPS13B GPR45 GABRA4	1.91e-04	1074	96	12	C0006142
Disease	Leydig cell tumor (is_marker_for)	FLT1 PDGFRB	2.90e-04	8	96	2	DOID:2696 (is_marker_for)
Disease	Thyroid carcinoma	TSC2 TSHR RET	4.01e-04	44	96	3	C0549473
Disease	quality of life during menstruation measurement, dysmenorrheic pain measurement	RB1CC1 VPS13B	5.65e-04	11	96	2	EFO_0007889, EFO_0009366
Disease	Hematologic Neoplasms	CBL CSF1R	6.77e-04	12	96	2	C0376545
Disease	renal cell carcinoma (is_marker_for)	FLT1 PDGFRB BIRC2 CSF1R	8.25e-04	128	96	4	DOID:4450 (is_marker_for)
Disease	Kuhnt-Junius degeneration (is_marker_for)	FLT1 PDGFRB	9.29e-04	14	96	2	DOID:10873 (is_marker_for)
Disease	diabetic retinopathy	VSTM2B KIAA0825 CCNL1 ARAP2	1.03e-03	136	96	4	EFO_0003770
Disease	Astrocytosis	ITGA2 TNR	1.38e-03	17	96	2	C3887640
Disease	Gliosis	ITGA2 TNR	1.38e-03	17	96	2	C0017639
Disease	renal cell carcinoma (is_implicated_in)	PDGFRB CSF1R SLC49A4	1.50e-03	69	96	3	DOID:4450 (is_implicated_in)
Disease	C-X-C motif chemokine 16 measurement	ZMYND15 XCR1	1.55e-03	18	96	2	EFO_0010911
Disease	Tourette syndrome, schizophrenia	DNAH10 YJEFN3	1.55e-03	18	96	2	EFO_0004895, MONDO_0005090
Disease	autism spectrum disorder (implicated_via_orthology)	TMPRSS9 PDGFRB TSC2 NLGN3	1.56e-03	152	96	4	DOID:0060041 (implicated_via_orthology)
Disease	Arthrogryposis	ASCC1 DYNC1H1	2.11e-03	21	96	2	C0003886
Disease	cervical squamous cell carcinoma (is_marker_for)	BIRC2 CSF1R	2.32e-03	22	96	2	DOID:3744 (is_marker_for)
Disease	Leukemia, Myelocytic, Acute	TSC2 CBL GFI1 CSF1R	2.49e-03	173	96	4	C0023467
Disease	Hereditary Paraganglioma-Pheochromocytoma Syndrome	RET MDH2	2.53e-03	23	96	2	C1708353
Disease	cardiac troponin I measurement	RYK PCNX2 GREB1 ARAP2	2.65e-03	176	96	4	EFO_0010071
Disease	West Syndrome	TSC2 PIGA	2.76e-03	24	96	2	C0037769
Disease	physical activity	SAMD4B LRRC7 ARAP2	3.00e-03	88	96	3	EFO_0003940

Protein segments in the cluster

Peptide	Gene	Start	Entry
VRTHFSTAYELPLLT	ALX4	281	Q9H161
RYRSLLVPSDFLSVH	CCAR2	246	Q8N163
ALLAHLVSPLYSTSL	ADAD2	411	Q8NCV1
LVSPLYSTSLILADS	ADAD2	416	Q8NCV1
TLHYLHSLLRPDLQT	ARHGEF40	571	Q8TER5
TDGIHLLSSLLLYES	CDK18	396	Q07002
SSVLRTLYSHLPVIH	DEPP1	196	Q9NTK1
SPTYLSLRELATHAA	AJM1	776	C9J069
STLRAPSLLYNLIHL	ASCC1	61	Q8N9N2
LILDSVNRHSYPLSS	ARAP2	441	Q8WZ64
LYSEVSLTIDHSLIP	CCNL1	46	Q9UK58
AVRLHTFLTTSLPAY	DMXL1	1546	Q9Y485
LELYSLQHSLSTEPA	DISP2	951	A7MBM2
SLRPDLLTVDSAHLY	QRICH1	281	Q2TAL8
DAYSHLSSRTLPEIV	KIAA1549	256	Q9HCM3
TLYFLHSESLPALDL	RB1CC1	1526	Q8TDY2
SLLLYHLPSVSITSL	PATL1	641	Q86TB9
PLSVISVSYTHILLT	OR2T2	211	Q6IF00
RHLPFTRSLTLSSLE	EYS	1856	Q5T1H1
SLSLLASRYARAHPS	KIAA0825	666	Q8IV33
HSLLRSDRPAYVTIL	NFRKB	566	Q6P4R8
TLSTHLLIHSDTRPY	GFI1	326	Q99684
IESTLSGHSLPLLRY	GREB1	861	Q4ZG55
PLAHHRTIYTTFLLL	NPY4R	206	P50391
LESLPSTIGYLHSLR	LRRC7	311	Q96NW7
NSPLVSRLTLYDIAH	MDH2	46	P40926
LLLPHATDIYSRSAN	HERC1	1021	Q15751
LVALSYHLSRQSSDP	PCNX2	1041	A6NKB5
YSTARLSILTPRHHL	FAT2	3751	Q9NYQ8
LLTSQPLDREATSHY	PCDHGC5	406	Q9Y5F6
STSSGYLLILHDLDL	DCAF10	316	Q5QP82
EHLTLLSASELIPYA	INTS2	776	Q9H0H0
TLSISARHSLPKVSY	GABRA4	301	P48169
LAIHNPLRYTSILTT	OR51A2	126	Q8NGJ7
LAIHNPLRYTSILTT	OR51A4	126	Q8NGJ6
PLLYDAEIHLTRSTN	ITGA2	931	P17301
PRALQATHYSLLATL	MFSD3	351	Q96ES6
LPHSVYSLLSVFSQR	GPR45	281	Q9Y5Y3
LSRHLYISSSNPDLI	PTPN21	581	Q16825
GIIYLTLPLSHLEST	DCHS2	826	Q6V1P9
HLALSDTLYVLSLPT	P2RY4	76	P51582
HDTLRLTALPDYTLT	NLGN3	781	Q9NZ94
TKDTYRHTFTLSLPR	CSF1R	356	P07333
YSDSPLILERSHLLS	IGSF10	381	Q6WRI0
YRTLKRSHSLPSSII	CCDC125	496	Q86Z20
ELSLLHTSLSAYAPA	CCNF	436	P41002
SITHLPLTTVTLYAS	SLC49A4	371	Q96SL1
LLRTVHSVLYSSPAI	GALNT3	201	Q14435
STLLRTVYSVLHTTP	GALNT6	191	Q8NCL4
RVLTLSEDSPYETLH	DYNC1H1	136	Q14204
HLYTTSLTTLTRYPD	KCTD6	21	Q8NC69
DLLPDTYQHLRTILS	CBL	86	P22681
TSPLRTRFVYHLSDL	JCHAIN	76	P01591
LPSNSSLTHYILDTR	CCDC168	4271	Q8NDH2
YSSHSASSLRPADLL	HPS1	221	Q92902
FPSEESLHLIYSSIL	DNAH10	2596	Q8IVF4
ISHYALSFSLLVPSE	RYK	91	P34925
AYDISQLRHPTALSL	CDH15	666	P55291
YLHTPRLTVSFSLLC	PKD1L1	1951	Q8TDX9
HLLQSTSLRSYLPPL	PHKA2	666	P46019
HGLRSPLDTSSVLYT	PDGFRB	996	P09619
SEKLTLLPTLYEIHS	RNF180	236	Q86T96
ILAISSDSRLHTPVY	OR1D2	46	P34982
SLTVYVISEHSSLLP	PIGS	141	Q96S52
GLLLDTSRHYLPLSS	HEXA	171	P06865
TSRHYLPLSSILDTL	HEXA	176	P06865
IYPTSILHILESSSD	TEX47	91	Q8TBZ9
LTPATTTLDLSYNLL	TLR10	46	Q9BXR5
TEYLFLLTILTKPHS	MICU2	161	Q8IYU8
RIHVSYLLTSVLPHL	MORC4	896	Q8TE76
SLDVYVARLSLSHSP	SHROOM2	1101	Q13796
SITHRTIPYLGLLTS	MT-ND5	531	P03915
LTLRLQDYPSLSHLV	PGAP1	426	Q75T13
PYVATLSLHSLFELR	SLC4A8	156	Q2Y0W8
IYSLLSFISIPHTIS	MRGPRX1	81	Q96LB2
LSYAHITLAVLRIPS	OR6B3	216	Q8NGW1
SFLIPSSLVDHLYLL	NUP160	566	Q12769
RYPHLLEQLLSTSDT	BIRC2	351	Q13490
STATTLFHSLPLLRY	PIGA	101	P37287
HRYLSVVSPLSTLRV	XCR1	126	P46094
SRLYLVFPHDSSALS	TBC1D17	181	Q9HA65
HLSLRLPYVESSSHL	nan	231	Q6ZTK2
SNYLISLDPTHLSRD	TULP2	331	O00295
YKLSRLPLHTLTSST	TMEM11	141	P17152
ESRQLLSYALIHPAT	SAMD4B	121	Q5PRF9
LSYALIHPATTLEDR	SAMD4B	126	Q5PRF9
LHYLVSSLTPLYTLT	TUBE1	296	Q9UJT0
FLLSSRDHRTPLLYA	SEMA3B	311	Q13214
SYTTDPLLSLLLLAL	VSTM2B	261	A6NLU5
FRLVDLLPSTHYTAT	TNR	1006	Q92752
YPTRSLDLLHRDLTT	YJEFN3	151	A6XGL0
PHLLTERLTDVYSTS	TTMP	126	Q5BVD1
TSDYHRTLTPTLEAL	TMPRSS9	76	Q7Z410
PLAHHRTIYTTFLLL	NPY4R2	206	P0DQD5
LHHLLRSTTLIYPTE	PSME4	721	Q14997
LGDLLLTPTRIYSHS	GART	651	P22102
SLHLPSTYSLSVSRR	RET	401	P07949
ITYSHSSPQLAASLR	nan	106	Q86TA4
LSRSAPTTLYLVHTD	ZNF704	291	Q6ZNC4
SYLVLHSSLVQALPS	ZACN	271	Q401N2
DSGLRYLASLPSHVL	ZCCHC14	176	Q8WYQ9
LRYHESSGPLETLSR	ZNF445	61	P59923
LLEEYIPTRHTSVTL	VPS13B	631	Q7Z7G8
PYLLRNLSDHTVAIS	FLT1	661	P17948
SSLGHSSLISYLVTL	HIVEP2	1961	P31629
HLRDLSPYISFVSLE	ZMYND15	96	Q9H091
ESRQLLSYALIHPAT	SAMD4A	121	Q9UPU9
LSYALIHPATSLEDR	SAMD4A	126	Q9UPU9
AHRLYSLRNSPTSVL	TSC2	306	P49815
LTVHASYLSTLPDLV	WDR43	531	Q15061
SLSFLHLTRADLSYP	TSHR	266	P16473
SLSTHAEPYTRRALA	WFS1	446	O76024
ITPLLYISTDLTHLQ	KIAA2013	551	Q8IYS2