Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF675 ZNF12 ZHX3 ZNF676 ZNF28 SALL1 ZNF555 FEZF1 ZSCAN4 ZNF483 ETV1 ZNF814 ZNF525 SALL4 ZBTB18 ZNF709 ZNF595 ZFP37 ZNF551 STAT5A ZNF639 STAT5B

9.71e-0914127722GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF675 ZNF12 ZHX3 ZNF676 ZNF28 SALL1 ZNF555 FEZF1 ZSCAN4 ZNF483 ETV1 ZNF814 ZNF525 SALL4 ZNF709 ZNF595 MED12 ZFP37 ZNF551 STAT5A ZNF639 STAT5B

1.76e-0814597722GO:0000977
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF675 ZNF12 ZNF676 ZNF28 SALL1 FEZF1 ZSCAN4 ZNF483 ETV1 ZNF814 ZNF525 SALL4 ZNF709 ZNF595 MED12 ZNF551 STAT5A ZNF639 STAT5B

1.72e-0712447719GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF675 ZNF12 ZNF676 ZNF28 SALL1 FEZF1 ZSCAN4 ZNF483 ETV1 ZNF814 ZNF525 SALL4 ZNF709 ZNF595 MED12 ZNF551 STAT5A ZNF639 STAT5B

2.40e-0712717719GO:0000987
GeneOntologyMolecularFunctionneurotrophin binding

PCSK6 FSTL4

9.45e-0412772GO:0043121
HumanPhenoAbnormal periauricular region morphology

SALL1 FBXO11 POLR1B SALL4 MED12 ZFPM2

1.02e-05131216HP:0000383
HumanPhenoBranchial anomaly

SALL1 FBXO11 POLR1B MED12 ZFPM2

1.24e-0578215HP:0009794
HumanPhenoRectovaginal fistula

SALL1 POLR1B SALL4

8.84e-0522213HP:0000143
HumanPhenoPreauricular pit

SALL1 FBXO11 MED12 ZFPM2

9.57e-0561214HP:0004467
HumanPhenoDuane anomaly

SALL1 FBXO11 SALL4

1.31e-0425213HP:0009921
HumanPhenoIncomitant strabismus

SALL1 FBXO11 SALL4

1.31e-0425213HP:0025068
HumanPhenoPeriauricular skin pits

SALL1 FBXO11 MED12 ZFPM2

1.38e-0467214HP:0100277
HumanPhenoRectal fistula

SALL1 POLR1B SALL4

1.48e-0426213HP:0100590
HumanPhenoVaginal fistula

SALL1 POLR1B SALL4

2.28e-0430213HP:0004320
MousePhenoabsent triquetrum

SALL1 SALL4

1.46e-052542MP:0030862
MousePhenoabnormal triquetrum morphology

SALL1 SALL4

4.38e-053542MP:0030861
DomainZINC_FINGER_C2H2_2

ZNF675 ZNF12 ZHX3 ZNF676 ZNF28 SALL1 ZNF555 FEZF1 ZSCAN4 ZNF483 ZNF814 ZNF525 SALL4 ZBTB18 ZNF709 ZNF595 ZFP37 ZFPM2 ZNF551 ZNF639

2.19e-117757620PS50157
DomainZINC_FINGER_C2H2_1

ZNF675 ZNF12 ZHX3 ZNF676 ZNF28 SALL1 ZNF555 FEZF1 ZSCAN4 ZNF483 ZNF814 ZNF525 SALL4 ZBTB18 ZNF709 ZNF595 ZFP37 ZFPM2 ZNF551 ZNF639

2.29e-117777620PS00028
Domainzf-C2H2

ZNF675 ZNF12 ZNF676 ZNF28 SALL1 ZNF555 FEZF1 ZSCAN4 ZNF483 ZNF814 ZNF525 SALL4 ZBTB18 ZNF709 ZNF595 ZFP37 ZFPM2 ZNF551 ZNF639

2.72e-116937619PF00096
DomainZnf_C2H2

ZNF675 ZNF12 ZHX3 ZNF676 ZNF28 SALL1 ZNF555 FEZF1 ZSCAN4 ZNF483 ZNF814 ZNF525 SALL4 ZBTB18 ZNF709 ZNF595 ZFP37 ZFPM2 ZNF551 ZNF639

4.32e-118057620IPR007087
DomainZnF_C2H2

ZNF675 ZNF12 ZHX3 ZNF676 ZNF28 SALL1 ZNF555 FEZF1 ZSCAN4 ZNF483 ZNF814 ZNF525 SALL4 ZBTB18 ZNF709 ZNF595 ZFP37 ZFPM2 ZNF551 ZNF639

4.61e-118087620SM00355
Domain-

ZNF675 ZNF12 ZNF676 ZNF28 SALL1 ZNF555 FEZF1 ZSCAN4 ZNF483 ZNF814 SALL4 ZBTB18 ZNF709 ZFP37 ZFPM2 ZNF551 ZNF639

1.43e-0967976173.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

ZNF675 ZNF12 ZNF676 ZNF28 SALL1 ZNF555 FEZF1 ZSCAN4 ZNF483 ZNF814 SALL4 ZBTB18 ZNF709 ZFP37 ZFPM2 ZNF551 ZNF639

1.99e-096947617IPR013087
DomainZnf_C2H2-like

ZNF675 ZNF12 ZHX3 ZNF676 ZNF28 SALL1 ZNF555 FEZF1 ZSCAN4 ZNF483 ZNF814 SALL4 ZBTB18 ZNF709 ZFP37 ZFPM2 ZNF551 ZNF639

2.17e-097967618IPR015880
DomainKRAB

ZNF675 ZNF12 ZNF676 ZNF28 ZNF555 ZNF483 ZNF814 ZNF709 ZNF595 ZFP37 ZNF551

2.07e-073587611PS50805
DomainKRAB

ZNF675 ZNF12 ZNF676 ZNF28 ZNF555 ZNF483 ZNF814 ZNF709 ZNF595 ZFP37 ZNF551

2.80e-073697611SM00349
DomainKRAB

ZNF675 ZNF12 ZNF676 ZNF28 ZNF555 ZNF483 ZNF814 ZNF709 ZNF595 ZFP37 ZNF551

2.88e-073707611IPR001909
Domainzf-C2H2_6

ZNF675 ZNF12 ZNF676 ZNF555 FEZF1 ZNF483 ZNF814 ZNF709 ZFP37 ZNF551

5.60e-073147610PF13912
DomainKRAB

ZNF675 ZNF12 ZNF28 ZNF555 ZNF483 ZNF814 ZNF709 ZNF595 ZFP37 ZNF551

1.83e-063587610PF01352
DomainMediator_Med12

MED12L MED12

1.63e-052762IPR019035
DomainMed12

MED12L MED12

1.63e-052762PF09497
DomainMediator_Med12_LCEWAV

MED12L MED12

1.63e-052762IPR021990
DomainMediator_Med12_catenin-bd

MED12L MED12

1.63e-052762IPR021989
DomainMed12-PQL

MED12L MED12

1.63e-052762PF12144
DomainMed12-LCEWAV

MED12L MED12

1.63e-052762PF12145
DomainMed12

MED12L MED12

1.63e-052762SM01281
DomainCLTH

RANBP10 RANBP9

2.43e-046762PF10607
DomainCRA

RANBP10 RANBP9

2.43e-046762SM00757
DomainCTLH/CRA

RANBP10 RANBP9

2.43e-046762IPR024964
DomainCRA_dom

RANBP10 RANBP9

2.43e-046762IPR013144
DomainSTAT_TF_prot_interaction

STAT5A STAT5B

3.39e-047762IPR013799
DomainSTAT_TF_DNA-bd_sub

STAT5A STAT5B

3.39e-047762IPR012345
DomainSTAT

STAT5A STAT5B

3.39e-047762IPR001217
DomainSTAT_TF_coiled-coil

STAT5A STAT5B

3.39e-047762IPR015988
Domain-

STAT5A STAT5B

3.39e-0477622.60.40.630
DomainSTAT_int

STAT5A STAT5B

3.39e-047762SM00964
DomainSTAT_TF_DNA-bd

STAT5A STAT5B

3.39e-047762IPR013801
DomainSTAT_bind

STAT5A STAT5B

3.39e-047762PF02864
DomainSTAT_int

STAT5A STAT5B

3.39e-047762PF02865
Domain-

STAT5A STAT5B

3.39e-0477621.10.532.10
DomainSTAT_alpha

STAT5A STAT5B

3.39e-047762PF01017
Domain-

STAT5A STAT5B

3.39e-0477621.20.1050.20
DomainSTAT_TF_alpha

STAT5A STAT5B

4.50e-048762IPR013800
DomainCTLH

RANBP10 RANBP9

5.77e-049762SM00668
DomainLisH

RANBP10 RANBP9

5.77e-049762PF08513
DomainCTLH_C

RANBP10 RANBP9

7.20e-0410762IPR006595
DomainCTLH

RANBP10 RANBP9

7.20e-0410762PS50897
Domain-

NID1 EGFL6

8.78e-04117622.40.155.10
DomainGFP-like

NID1 EGFL6

8.78e-0411762IPR023413
DomainLisH

RANBP10 RANBP9

5.77e-0328762SM00667
DomainLisH

RANBP10 RANBP9

5.77e-0328762IPR006594
DomainLISH

RANBP10 RANBP9

5.77e-0328762PS50896
Domain-

TENM1 NID1

1.10e-02397622.120.10.30
PathwayKEGG_MEDICUS_REFERENCE_PRL_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

1.65e-045582M49006
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

1.65e-045582M48987
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

1.65e-045582M48986
PathwayREACTOME_INTERLEUKIN_9_SIGNALING

STAT5A STAT5B

2.47e-046582MM15581
PathwayREACTOME_INTERLEUKIN_21_SIGNALING

STAT5A STAT5B

2.47e-046582MM15621
PathwayREACTOME_STAT5_ACTIVATION

STAT5A STAT5B

3.45e-047582M27953
PathwayKEGG_MEDICUS_REFERENCE_EGF_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

3.45e-047582M47430
PathwayKEGG_MEDICUS_PATHOGEN_HTLV_1_P12_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

3.45e-047582M47581
PathwayKEGG_MEDICUS_REFERENCE_GH_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

3.45e-047582M47646
PathwayREACTOME_ERYTHROPOIETIN_ACTIVATES_STAT5

STAT5A STAT5B

3.45e-047582M27907
PathwayREACTOME_INTERLEUKIN_9_SIGNALING

STAT5A STAT5B

5.88e-049582M27861
PathwayBIOCARTA_IL22BP_PATHWAY

STAT5A STAT5B

5.88e-049582MM1419
PathwayBIOCARTA_IL22BP_PATHWAY

STAT5A STAT5B

5.88e-049582M8066
PathwayPID_TCPTP_PATHWAY

CSF1 STAT5A STAT5B

6.77e-0442583M91
PathwayREACTOME_INTERLEUKIN_21_SIGNALING

STAT5A STAT5B

7.33e-0410582M27898
PathwayREACTOME_STAT5_ACTIVATION_DOWNSTREAM_OF_FLT3_ITD_MUTANTS

STAT5A STAT5B

7.33e-0410582M41731
PathwayREACTOME_MET_ACTIVATES_RAS_SIGNALING

RANBP10 RANBP9

7.33e-0410582MM15488
PathwayREACTOME_INTERLEUKIN_2_SIGNALING

STAT5A STAT5B

7.33e-0410582MM15618
PathwayREACTOME_MET_ACTIVATES_RAS_SIGNALING

RANBP10 RANBP9

8.93e-0411582M27740
PathwayREACTOME_SIGNALING_BY_LEPTIN

STAT5A STAT5B

8.93e-0411582M27195
PathwayREACTOME_INTERLEUKIN_15_SIGNALING

STAT5A STAT5B

8.93e-0411582MM15578
PathwayREACTOME_GENERIC_TRANSCRIPTION_PATHWAY

ZNF12 ZNF28 ZNF483 ZNF814 PSMD5 SESN2 ZNF709 ZNF595 ZFP37 ZNF551

1.05e-037685810MM14851
PathwayREACTOME_INTERLEUKIN_2_SIGNALING

STAT5A STAT5B

1.07e-0312582M27893
PathwayWP_MAMMARY_GLAND_DEVELOPMENT_PUBERTY_STAGE_2_OF_4

TIMP1 STAT5A

1.26e-0313582M39582
PathwayREACTOME_POU5F1_OCT4_SOX2_NANOG_ACTIVATE_GENES_RELATED_TO_PROLIFERATION

SALL1 SALL4

1.26e-0313582M27209
PathwayPID_PTP1B_PATHWAY

CSF1 STAT5A STAT5B

1.27e-0352583M50
PathwayREACTOME_INTERLEUKIN_15_SIGNALING

STAT5A STAT5B

1.47e-0314582M27858
PathwayPID_IL5_PATHWAY

STAT5A STAT5B

1.47e-0314582M135
PathwayREACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS

ZNF28 ZNF709 ZNF595

1.57e-0356583MM17236
PathwayREACTOME_PROLACTIN_RECEPTOR_SIGNALING

STAT5A STAT5B

1.69e-0315582M552
PathwayBIOCARTA_IL3_PATHWAY

STAT5A STAT5B

1.69e-0315582MM1412
PathwayBIOCARTA_IL3_PATHWAY

STAT5A STAT5B

1.69e-0315582M17681
PathwayWP_FOXP3_IN_COVID19

STAT5A STAT5B

1.69e-0315582M42573
PathwayREACTOME_INTERLEUKIN_7_SIGNALING

STAT5A STAT5B

1.69e-0315582MM14536
PathwayBIOCARTA_IL7_PATHWAY

STAT5A STAT5B

1.92e-0316582M1296
PathwayBIOCARTA_IL7_PATHWAY

STAT5A STAT5B

1.92e-0316582MM1420
PathwayREACTOME_SIGNALING_BY_FLT3_ITD_AND_TKD_MUTANTS

STAT5A STAT5B

1.92e-0316582M41733
PathwayREACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING

STAT5A STAT5B

1.92e-0316582MM15710
PathwayWP_IL9_SIGNALING

STAT5A STAT5B

2.17e-0317582M39644
PathwayKEGG_MEDICUS_REFERENCE_HORMONE_LIKE_CYTOKINE_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

2.17e-0317582M47905
PathwayREACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION

ZNF28 POLR1B ZNF709 ZNF595

2.35e-03136584MM14848
PathwayREACTOME_SIGNALING_BY_CYTOSOLIC_FGFR1_FUSION_MUTANTS

STAT5A STAT5B

2.44e-0318582M673
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

ZNF12 ZNF28 ZNF483 ZNF814 POLR1B PSMD5 SESN2 ZNF709 ZNF595 ZFP37 ZNF551

2.67e-0310225811MM15436
PathwayREACTOME_SIGNALING_BY_FLT3_FUSION_PROTEINS

STAT5A STAT5B

2.72e-0319582M41732
PathwayBIOCARTA_EPO_PATHWAY

STAT5A STAT5B

2.72e-0319582M12836
PathwayWP_BRAINDERIVED_NEUROTROPHIC_FACTOR_BDNF_SIGNALING

KCNA3 RANBP9 STAT5A STAT5B

2.89e-03144584M39691
PathwayREACTOME_INTERLEUKIN_20_FAMILY_SIGNALING

STAT5A STAT5B

3.01e-0320582MM15496
PathwayREACTOME_SIGNALING_BY_KIT_IN_DISEASE

STAT5A STAT5B

3.01e-0320582M39002
PathwayBIOCARTA_EPO_PATHWAY

STAT5A STAT5B

3.01e-0320582MM1389
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

ZNF675 ZNF12 ZNF676 ZNF28 ZNF555 ZNF483 PSMD5 SESN2 ZNF709 ZNF595 MED12 ZFP37 ZNF551

3.57e-0313875813M734
PathwayBIOCARTA_IL2_PATHWAY

STAT5A STAT5B

3.65e-0322582M7747
PathwayBIOCARTA_IL2_PATHWAY

STAT5A STAT5B

3.98e-0323582MM1411
PathwayBIOCARTA_GLEEVEC_PATHWAY

STAT5A STAT5B

3.98e-0323582MM1424
PathwayBIOCARTA_GLEEVEC_PATHWAY

STAT5A STAT5B

3.98e-0323582M7897
PathwayKEGG_MEDICUS_REFERENCE_IL2_FAMILY_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

3.98e-0323582M47904
Pubmed

Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation.

CSF1 STAT5A STAT5B

2.16e-07678310652277
Pubmed

Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms.

CSF1 STAT5A STAT5B

2.35e-061278337550517
Pubmed

Definitive evidence using enucleated cytoplasts for a nongenomic basis for the cystic change in endoplasmic reticulum structure caused by STAT5a/b siRNAs.

STAT5A STAT5B

4.97e-06278223151802
Pubmed

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.

STAT5A STAT5B

4.97e-06278226999798
Pubmed

Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.

STAT5A STAT5B

4.97e-06278220233708
Pubmed

Involvement of the STAT5 signaling pathway in the regulation of mouse preimplantation development.

STAT5A STAT5B

4.97e-06278216775227
Pubmed

A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions.

STAT5A STAT5B

4.97e-06278231443474
Pubmed

STAT5 isoforms: controversies and clarifications.

STAT5A STAT5B

4.97e-06278217447893
Pubmed

Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.

STAT5A STAT5B

4.97e-06278212377952
Pubmed

Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts.

SALL1 SALL4

4.97e-06278219476507
Pubmed

A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development.

STAT5A STAT5B

4.97e-06278221127177
Pubmed

The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.

STAT5A STAT5B

4.97e-06278216289657
Pubmed

Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.

STAT5A STAT5B

4.97e-06278225552366
Pubmed

Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.

STAT5A STAT5B

4.97e-06278225470773
Pubmed

Constitutively active Stat5A and Stat5B promote adipogenesis.

STAT5A STAT5B

4.97e-06278221431790
Pubmed

Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence.

STAT5A STAT5B

4.97e-06278216115927
Pubmed

Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration.

STAT5A STAT5B

4.97e-06278223275557
Pubmed

Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury.

STAT5A STAT5B

4.97e-06278228500076
Pubmed

STAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen species.

STAT5A STAT5B

4.97e-06278221826656
Pubmed

Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation.

STAT5A STAT5B

4.97e-06278211867689
Pubmed

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

STAT5A STAT5B

4.97e-0627827720707
Pubmed

Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes.

STAT5A STAT5B

4.97e-06278215980098
Pubmed

STAT5A and STAT5B have opposite correlations with drug response gene expression.

STAT5A STAT5B

4.97e-06278227264955
Pubmed

Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation.

STAT5A STAT5B

4.97e-06278215340066
Pubmed

Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function.

STAT5A STAT5B

4.97e-06278222159083
Pubmed

STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.

STAT5A STAT5B

4.97e-06278220008792
Pubmed

STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.

STAT5A STAT5B

4.97e-06278233199496
Pubmed

Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family.

SALL1 SALL4

4.97e-06278212395297
Pubmed

STAT5A/B gene locus undergoes amplification during human prostate cancer progression.

STAT5A STAT5B

4.97e-06278223660011
Pubmed

Role of Stat5 in type I interferon-signaling and transcriptional regulation.

STAT5A STAT5B

4.97e-06278212901872
Pubmed

O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies.

STAT5A STAT5B

4.97e-06278228074064
Pubmed

Sall4 is essential for stabilization, but not for pluripotency, of embryonic stem cells by repressing aberrant trophectoderm gene expression.

SALL1 SALL4

4.97e-06278219350679
Pubmed

STAT5b: A master regulator of key biological pathways.

STAT5A STAT5B

4.97e-06278236755813
Pubmed

The influence of STAT5 antisense oligodeoxynucleotides on the proliferation and apoptosis of selected human cutaneous T-cell lymphoma cell lines.

STAT5A STAT5B

4.97e-06278216502315
Pubmed

Stat5: an essential regulator of mast cell biology.

STAT5A STAT5B

4.97e-06278212217382
Pubmed

Identification of isoform-specific dynamics in phosphorylation-dependent STAT5 dimerization by quantitative mass spectrometry and mathematical modeling.

STAT5A STAT5B

4.97e-06278225333863
Pubmed

A role for STAT5 in the pathogenesis of IL-2-induced glucocorticoid resistance.

STAT5A STAT5B

4.97e-06278212421978
Pubmed

A single amino acid in the DNA binding regions of STAT5A and STAT5B confers distinct DNA binding specificities.

STAT5A STAT5B

4.97e-0627829852045
Pubmed

Brain STAT5 Modulates Long-Term Metabolic and Epigenetic Changes Induced by Pregnancy and Lactation in Female Mice.

STAT5A STAT5B

4.97e-06278231599926
Pubmed

Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior.

STAT5A STAT5B

4.97e-06278219966185
Pubmed

Signal transducer and activator of transcription 5a/b: biomarker and therapeutic target in prostate and breast cancer.

STAT5A STAT5B

4.97e-06278221704724
Pubmed

DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.

STAT5A STAT5B

4.97e-06278210594041
Pubmed

Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells.

STAT5A STAT5B

4.97e-06278221036145
Pubmed

Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice.

STAT5A STAT5B

4.97e-06278210486277
Pubmed

Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.

STAT5A STAT5B

4.97e-06278238618957
Pubmed

Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.

STAT5A STAT5B

4.97e-06278216840779
Pubmed

The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.

STAT5A STAT5B

4.97e-06278215128421
Pubmed

STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.

STAT5A STAT5B

4.97e-06278230377054
Pubmed

Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung.

STAT5A STAT5B

4.97e-06278223565285
Pubmed

Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.

STAT5A STAT5B

4.97e-06278232790723
Pubmed

Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone.

STAT5A STAT5B

4.97e-0627828732682
Pubmed

In vivo identification of novel STAT5 target genes.

STAT5A STAT5B

4.97e-06278218492722
Pubmed

How Intrinsic Molecular Dynamics Control Intramolecular Communication in Signal Transducers and Activators of Transcription Factor STAT5.

STAT5A STAT5B

4.97e-06278226717567
Pubmed

Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption.

STAT5A STAT5B

4.97e-06278210066807
Pubmed

Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains.

STAT5A STAT5B

4.97e-06278210835485
Pubmed

Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis.

STAT5A STAT5B

4.97e-06278235464049
Pubmed

The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5.

STAT5A STAT5B

4.97e-06278232281944
Pubmed

Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity.

STAT5A STAT5B

4.97e-06278218286195
Pubmed

Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells.

STAT5A STAT5B

4.97e-06278223773921
Pubmed

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.

STAT5A STAT5B

4.97e-0627828631883
Pubmed

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.

STAT5A STAT5B

4.97e-06278211030348
Pubmed

Association between STAT5 polymorphisms and glioblastoma risk in Han Chinese population.

STAT5A STAT5B

4.97e-06278224878107
Pubmed

Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice.

STAT5A STAT5B

4.97e-06278234818373
Pubmed

Regulation of eosinophil apoptosis by nitric oxide: Role of c-Jun-N-terminal kinase and signal transducer and activator of transcription 5.

STAT5A STAT5B

4.97e-06278212847485
Pubmed

Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma.

STAT5A STAT5B

4.97e-06278212835478
Pubmed

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

STAT5A STAT5B

4.97e-0627827568026
Pubmed

Identification of STAT5A and STAT5B target genes in human T cells.

STAT5A STAT5B

4.97e-06278224497979
Pubmed

Interference of propofol with signal transducer and activator of transcription 5 activation and cardioprotection by remote ischemic preconditioning during coronary artery bypass grafting.

STAT5A STAT5B

4.97e-06278223465551
Pubmed

STAT5 promotes multilineage hematolymphoid development in vivo through effects on early hematopoietic progenitor cells.

STAT5A STAT5B

4.97e-06278211756158
Pubmed

Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.

STAT5A STAT5B

4.97e-06278217536022
Pubmed

STAT5 transcriptional activity is impaired by LIF in a mammary epithelial cell line.

STAT5A STAT5B

4.97e-06278217382296
Pubmed

STAT5 is essential for Akt/p70S6 kinase activity during IL-2-induced lymphocyte proliferation.

STAT5A STAT5B

4.97e-06278217911616
Pubmed

STAT5 signaling in sexually dimorphic gene expression and growth patterns.

STAT5A STAT5B

4.97e-06278210486314
Pubmed

The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging.

STAT5A STAT5B

4.97e-06278217599554
Pubmed

MiR-21 is under control of STAT5 but is dispensable for mammary development and lactation.

STAT5A STAT5B

4.97e-06278224497923
Pubmed

IL-3 Differentially Regulates Membrane and Soluble RANKL in Osteoblasts through Metalloproteases and the JAK2/STAT5 Pathway and Improves the RANKL/OPG Ratio in Adult Mice.

STAT5A STAT5B

4.97e-06278229203513
Pubmed

Prognostic significance of signal transducer and activator of transcription 5 and 5b expression in Epstein-Barr virus-positive patients with chronic lymphocytic leukemia.

STAT5A STAT5B

4.97e-06278227367207
Pubmed

Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.

STAT5A STAT5B

4.97e-06278216493008
Pubmed

Constitutive activation of STAT5A and STAT5B regulates IgM secretion in Waldenstrom's macroglobulinemia.

STAT5A STAT5B

4.97e-06278224335105
Pubmed

Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.

STAT5A STAT5B

4.97e-0627828816482
Pubmed

Brain STAT5 signaling modulates learning and memory formation.

STAT5A STAT5B

4.97e-06278229460051
Pubmed

The role of STAT proteins in growth hormone signaling.

STAT5A STAT5B

4.97e-06278210851057
Pubmed

Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice.

STAT5A STAT5B

4.97e-06278228806763
Pubmed

Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells.

STAT5A STAT5B

4.97e-06278229105654
Pubmed

STAT5 activity in pancreatic beta-cells influences the severity of diabetes in animal models of type 1 and 2 diabetes.

STAT5A STAT5B

4.97e-06278217003334
Pubmed

Stat5 activation inhibits prolactin-induced AP-1 activity: distinct prolactin-initiated signals in tumorigenesis dependent on cell context.

STAT5A STAT5B

4.97e-06278217438530
Pubmed

Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors.

STAT5A STAT5B

4.97e-06278215677477
Pubmed

A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: insights from gene expression profiling.

STAT5A STAT5B

4.97e-06278216757175
Pubmed

Identification of a distal STAT5-binding DNA region that may mediate growth hormone regulation of insulin-like growth factor-I gene expression.

STAT5A STAT5B

4.97e-06278215677453
Pubmed

Haploinsufficiency identifies STAT5 as a modifier of IL-7-induced lymphomas.

STAT5A STAT5B

4.97e-06278215870688
Pubmed

STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development.

STAT5A STAT5B

4.97e-06278228606561
Pubmed

Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A.

STAT5A STAT5B

4.97e-06278219833766
Pubmed

Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus.

STAT5A STAT5B

4.97e-06278217317776
Pubmed

Mouse homolog of SALL1, a causative gene for Townes-Brocks syndrome, binds to A/T-rich sequences in pericentric heterochromatin via its C-terminal zinc finger domains.

SALL1 SALL4

4.97e-06278217295837
Pubmed

Deregulation of STAT-5 isoforms in the development of HPV-mediated cervical carcinogenesis.

STAT5A STAT5B

4.97e-06278220415542
Pubmed

Role of arachidonic acid metabolism in Stat5 activation induced by oleic acid in MDA-MB-231 breast cancer cells.

STAT5A STAT5B

4.97e-06278223332799
Pubmed

Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells.

STAT5A STAT5B

4.97e-06278212393407
Pubmed

[Effect of STAT5 gene silencing on the proliferation of T lymphocytes in a mouse model of asthma].

STAT5A STAT5B

4.97e-06278222455944
Pubmed

The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter.

STAT5A STAT5B

4.97e-06278212039059
Pubmed

The Role of STAT5 in Tyrosine Kinase Inhibitor (IMATINIB) Resistance in CML Patients.

STAT5A STAT5B

4.97e-06278232041920
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF675 ZNF12 ZHX3 ZNF676 ZNF28 SALL1 ZNF555 FEZF1 ZSCAN4 ZNF483 ZNF814 ZNF525 SALL4 ZBTB18 ZNF709 ZNF595 ZFP37 ZFPM2 ZNF551 ZNF639

4.77e-14718592028
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 TENM1 SALL4 TEX11 HYDIN SORCS1

8.03e-071847762cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 TENM1 SALL4 TEX11 HYDIN SORCS1

8.03e-07184776ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 TENM1 SALL4 TEX11 HYDIN SORCS1

8.03e-071847762b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZHX3 ABCA13 TENM1 RP1 HYDIN DNAH14

8.56e-07186776f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZHX3 ABCA13 TENM1 RP1 HYDIN DNAH14

8.83e-07187776c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZHX3 ABCA13 TENM1 RP1 HYDIN DNAH14

9.11e-07188776af740fa78542438fdff627ea1f74f4eee43316be
ToppCellhematopoetic_progenitors-CD34+_MEP_1|hematopoetic_progenitors / Lineage and Cell class

RNASE1 CSF1 ZNF555 TIMP1 MED12L STAT5A

1.20e-061977766172a1b98ff840d9174b1ab20ba0c202a7ef87af
ToppCellBronchial_Biopsy-Immune-Mast_cells|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

ZHX3 ZNF28 CSF1 ZNF483 ZNF525

1.09e-0516877545ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCelldroplet-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA1A ABCA13 PCSK6 TEX15 EGFL6

1.64e-0518377503c7e69136d5a3b9c5b2c91733e9b1c791f45c49
ToppCell3'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF675 ZNF12 DLG5 PLA1A ZFPM2

2.23e-051957756a0460d949ccda7c9fe76870d3ee6c2f60677d61
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ZNF555 FSTL4 ZNF814 ZNF709 ZNF551

2.34e-05197775fd76cc5e12c7e7943a48f739e4f0626ff7211f51
Drug6-chloro-5H-purine

EXOSC10 RNASE1 SALL1

4.22e-0610763CID000407006
DrugFenoprofen calcium salt dihydrate [53746-45-5]; Up 200; 7.2uM; MCF7; HT_HG-U133A

RNASE1 CSF1 PCSK6 ETV1 STAT5A ZNF639 TTLL7

4.45e-061987673612_UP
DiseaseUDP-glucuronosyltransferase 2A1 measurement

PCSK6 ZFPM2

3.81e-054752EFO_0802186
Diseaseplatelet-derived growth factor subunit b measurement

PCSK6 ZFPM2

3.81e-054752EFO_0020650
Diseaselymphocyte count

LRRC8C RANBP10 CSF1 TIMP1 MED12L ETV1 PHLPP1 POLR1B SESN2 ERVW-1 AP3D1 ZFPM2 STAT5B

7.48e-0514647513EFO_0004587
Diseasepneumococcal bacteremia

LAMB4 ETV1

3.45e-0411752EFO_1001925
Diseasedisks large homolog 3 measurement

TEX11 ZFPM2

4.14e-0412752EFO_0802472
Diseasemonocyte percentage of leukocytes

MS4A4A AHI1 KCNA3 CSF1 PHLPP1 ZMYM4 SF3B5 EGFL6

5.34e-04731758EFO_0007989
Diseasemethadone dose measurement

MS4A4A TEX15 SORCS1

5.36e-0462753EFO_0007907
Diseasemyeloid white cell count

DLG5 AHI1 CSF1 MED12L ETV1 POLR1B RP1 RMND1 ZFPM2

6.08e-04937759EFO_0007988
Diseasehepatoblastoma (is_marker_for)

SALL1 SALL4

6.55e-0415752DOID:687 (is_marker_for)
Diseaseinterferon gamma measurement, platelet-derived growth factor BB measurement, interleukin 4 measurement, interleukin 10 measurement, stromal cell-derived factor 1 alpha measurement, interleukin-6 measurement, interleukin 12 measurement, interleukin 17 measurement, vascular endothelial growth factor measurement, fibroblast growth factor basic measurement, granulocyte colony-stimulating factor measurement

PCSK6 ZFPM2

7.48e-0416752EFO_0004750, EFO_0004753, EFO_0004762, EFO_0004810, EFO_0008130, EFO_0008142, EFO_0008165, EFO_0008174, EFO_0008184, EFO_0008264, EFO_0008293
DiseaseLimb Deformities, Congenital

SALL1 SALL4

8.46e-0417752C0206762
Diseasejuvenile idiopathic arthritis

LAMB4 AHI1 ABCA13

8.98e-0474753EFO_0002609
Diseaseempathy measurement

RANBP10 FSTL4 PHLPP1 RMND1

9.40e-04170754EFO_0009183
Diseaseotitis media (implicated_via_orthology)

FBXO11 SALL4

1.42e-0322752DOID:10754 (implicated_via_orthology)
Diseasemonocyte count

MS4A4A AHI1 KCNA3 CSF1 MED12L POLR1B AP3D1 SF3B5 ZFPM2 EGFL6

1.83e-0313207510EFO_0005091
Diseasecolon adenocarcinoma (is_implicated_in)

STAT5A STAT5B

1.99e-0326752DOID:234 (is_implicated_in)
Diseasegastric adenocarcinoma (is_marker_for)

STAT5A STAT5B

2.31e-0328752DOID:3717 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
NTHGSYKCFCLSGHM

EGFL6

111

Q8IUX8
FINSLCFDTEGHHMY

AHI1

746

Q8N157
RCRNFSYEGSMEHHF

ABCA13

81

Q86UQ4
DSCASMYSRSIQGHH

AP3D1

1101

O14617
KMVSSYLVHHGYCAT

RANBP9

371

Q96S59
VHHGYCATATAFARM

RANBP10

266

Q6VN20
HAAVCRPLHYTTTMT

OR5B21

121

A6NL26
FIRHDVFSHDAYMCT

MED12L

606

Q86YW9
ACNITFSRHETYMVH

ZFPM2

691

Q8WW38
SCRRGFYHHQEMNTC

PCSK6

766

P29122
HYRTTVISHSYCEHM

OR52A5

171

Q9H2C5
TDLHSYVVMNHGRSY

NID1

456

P14543
FFVSRFSEMCHSSHD

EFR3B

141

Q9Y2G0
SCHSIYMRQEGFLAH

ETV1

271

P50549
SHRTCSDYSEMRATH

DLG5

1236

Q8TDM6
QSQYMHVGSCQHLSS

KCNA3

496

P22001
HDVFSHNMYTCTLIS

MED12

606

Q93074
VHVTVDTYSHFMCAT

ERVK-18

666

Q9QC07
HHSYRSFLGLTCLMQ

EXOSC10

316

Q01780
MCIASHSHAFATVSF

HYDIN

3421

Q4G0P3
TSSFLHHQMGLCYRA

IFIT5

281

Q13325
SEYCSHMIGSGHLQS

CSF1

36

P09603
PMHDFYRCHTCNTTD

FBXO11

846

Q86XK2
HSMCTSHYLDIFITF

CACNA1I

1481

Q9P0X4
VTTIHMGNYTCHASG

FSTL4

311

Q6MZW2
YQDCFSDSQSHMHSV

DNAH14

896

Q0VDD8
MHQTYSRHCRPEEST

MS4A4A

1

Q96JQ5
SHSSRCHFDMTTYLA

LAMB4

336

A4D0S4
HGFITMHSCSINGKY

SACM1L

191

Q9NTJ5
SCQSALKMHYRTHTG

SALL1

716

Q9NSC2
SCQSSLKMHYRTHTG

SALL4

576

Q9UJQ4
MCCPSRRYHHTSDEN

MDFIC2

136

A0A1B0GVS7
HFYHGRTETMRSCTV

CROT

446

Q9UKG9
SGENKSEYHMFTHSC

RP1

491

P56715
RHHTISYTGCLTQMY

OR1N1

86

Q8NGS0
ARHQCSYLVGSHMAE

SESN2

121

P58004
TFTAHTHMPRNCYHS

ERVW-1

61

Q9UQF0
IHSVSYGHVAACQLM

PLEKHH3

701

Q7Z736
HTCGDYMFSGHTVVL

SAMD8

291

Q96LT4
HSSFHAMGALCYLNR

FEZF1

151

A0PJY2
MHCTAFATADEYHLG

RMND1

171

Q9NWS8
HTLCSGYQTDMHSVS

TENM1

81

Q9UKZ4
CVMEYHQATGTLSAH

STAT5B

401

P51692
SMHITDCRLTNGSRY

RNASE1

106

P07998
HRDSYCSYMGHFDLL

SF3B5

36

Q9BWJ5
CVMEYHQATGTLSAH

STAT5A

401

P42229
YNMVHRIDSDTFICH

STARD6

81

P59095
CGKSFSQMSSLTYHH

ZNF525

276

Q8N782
TPAMESVCGYFHRSH

TIMP1

86

P01033
TSSAPYCMHHSLVEF

PLA1A

331

Q53H76
TECGRSFYMSHLTQH

ZNF595

176

Q8IYB9
YVRSFCMLSHLSQHE

ZNF676

146

Q8N7Q3
ECGQAYSCRSHLRMH

ZNF555

176

Q8NEP9
GFSSMLEYCKHLNSH

ZNF639

411

Q9UID6
SYGHCMVAHRDSLYV

KBTBD13

341

C9JR72
RAHRAVLASCSMYFH

ZBTB18

36

Q99592
TSMRGFCFSADLHQH

ZNF551

136

Q7Z340
QMTSSLHHLCYNFGV

TEX11

216

Q8IYF3
AFSCSSSFRMHERIH

ZNF709

456

Q8N972
CKTSYRQSSTYHRHM

ZSCAN4

401

Q8NAM6
FCMLSHLTRHERNYT

ZNF675

181

Q8TD23
CGKTFSQMSNLVYHH

ZNF28

696

P17035
DCGMTFSHFTSVIYH

ZNF483

611

Q8TF39
RGCVHVFDRHMASTY

PHLPP1

201

O60346
TCIEMVTSLAYTHHG

PSMD5

226

Q16401
GKCFSQMSYLTIHHR

ZNF12

611

P17014
KHTFYGIESHRCMET

TYW1

396

Q9NV66
HSHENMLCEEFVTSY

TEX15

696

Q9BXT5
TQYGVSMHCVREEHS

POLR1B

206

Q9H9Y6
DMKSCATFSSSHRYH

SEC31A

56

O94979
ARTVDGHSHYLTCRM

SORCS1

336

Q8WY21
GHSHYLTCRMQNCTE

SORCS1

341

Q8WY21
YCDFRSHDMTQFVGH

ZHX3

81

Q9H4I2
YHMRTHTGESPFECN

ZFP37

506

Q9Y6Q3
CSAMAYHHDSRRIFV

WDFY1

71

Q8IWB7
HLAMSDGSIRNFCSY

ZMYM4

591

Q5VZL5
SYMRHLPHSNDACST

TTLL7

646

Q6ZT98
GAHYSCGESMKHFST

ZNF814

211

B7Z6K7
TGYKNFSCNHTMAHL

LRRC8C

301

Q8TDW0