Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase binding	MICALL1 KCTD13 RASA1 EHD1 DIAPH1 ARHGEF2 RIC1 IQGAP1	2.38e-05	360	66	8	GO:0051020
GeneOntologyMolecularFunction	small GTPase binding	MICALL1 KCTD13 EHD1 DIAPH1 ARHGEF2 RIC1 IQGAP1	8.98e-05	321	66	7	GO:0031267
GeneOntologyMolecularFunction	lipid kinase activity	DGKD DGKH ATM	3.36e-04	41	66	3	GO:0001727
GeneOntologyMolecularFunction	ATP-dependent diacylglycerol kinase activity	DGKD DGKH	5.81e-04	11	66	2	GO:0004143
GeneOntologyCellularComponent	ciliary pocket membrane	EHD1 EHD3	2.94e-05	3	66	2	GO:0020018
GeneOntologyCellularComponent	ciliary pocket	EHD1 EHD3	2.94e-05	3	66	2	GO:0020016
GeneOntologyCellularComponent	cell projection membrane	PDE6A VEZT PACSIN1 EHD1 DIAPH1 ARHGEF2 EHD3	4.12e-04	431	66	7	GO:0031253
GeneOntologyCellularComponent	recycling endosome membrane	MICALL1 EHD1 ATP11C EHD3	4.36e-04	112	66	4	GO:0055038
GeneOntologyCellularComponent	ruffle	RASA1 PACSIN1 DIAPH1 ARHGEF2 IQGAP1	4.86e-04	206	66	5	GO:0001726
Domain	Spin-Ssty	SPIN2A SPIN2B SPIN4	4.00e-07	5	65	3	PF02513
Domain	SPIN/Ssty	SPIN2A SPIN2B SPIN4	4.00e-07	5	65	3	IPR003671
Domain	SPIN-2	SPIN2A SPIN2B	1.19e-05	2	65	2	IPR029564
Domain	EHD1/EHD3	EHD1 EHD3	1.19e-05	2	65	2	IPR029951
Domain	EHD_N	EHD1 EHD3	1.18e-04	5	65	2	IPR031692
Domain	EHD_N	EHD1 EHD3	1.18e-04	5	65	2	PF16880
Domain	PH	RASA1 KIF1B SPTBN2 DGKD DGKH ARHGEF2	1.44e-04	229	65	6	PF00169
Domain	SAM	SCMH1 SCML1 DGKD DGKH	2.50e-04	88	65	4	SM00454
Domain	SAM_DOMAIN	SCMH1 SCML1 DGKD DGKH	3.35e-04	95	65	4	PS50105
Domain	SAM	SCMH1 SCML1 DGKD DGKH	3.63e-04	97	65	4	IPR001660
Domain	PH	RASA1 KIF1B SPTBN2 DGKD DGKH ARHGEF2	4.08e-04	278	65	6	SM00233
Domain	-	RASA1 KIF1B SPTBN2 DGKD DGKH ARHGEF2 RGS12	4.09e-04	391	65	7	2.30.29.30
Domain	PH_DOMAIN	RASA1 KIF1B SPTBN2 DGKD DGKH ARHGEF2	4.16e-04	279	65	6	PS50003
Domain	PH_domain	RASA1 KIF1B SPTBN2 DGKD DGKH ARHGEF2	4.23e-04	280	65	6	IPR001849
Domain	-	SCMH1 SCML1 DGKD DGKH	5.09e-04	106	65	4	1.10.150.50
Domain	DAGK_acc	DGKD DGKH	5.27e-04	10	65	2	PF00609
Domain	Diacylglycerol_kin_accessory	DGKD DGKH	5.27e-04	10	65	2	IPR000756
Domain	EF-hand_4	EHD1 EHD3	5.27e-04	10	65	2	PF12763
Domain	DAGKa	DGKD DGKH	5.27e-04	10	65	2	SM00045
Domain	EH	EHD1 EHD3	6.43e-04	11	65	2	PS50031
Domain	EH	EHD1 EHD3	6.43e-04	11	65	2	SM00027
Domain	EH_dom	EHD1 EHD3	6.43e-04	11	65	2	IPR000261
Domain	PH_dom-like	RASA1 KIF1B SPTBN2 DGKD DGKH ARHGEF2 RGS12	6.81e-04	426	65	7	IPR011993
Domain	SAM/pointed	SCMH1 SCML1 DGKD DGKH	7.38e-04	117	65	4	IPR013761
Domain	C1_1	DGKD DGKH ARHGEF2	1.03e-03	57	65	3	PF00130
Domain	RasGAP	RASA1 IQGAP1	1.06e-03	14	65	2	SM00323
Domain	G_DYNAMIN_dom	EHD1 EHD3	1.06e-03	14	65	2	IPR030381
Domain	DAGKc	DGKD DGKH	1.06e-03	14	65	2	SM00046
Domain	RasGAP_CS	RASA1 IQGAP1	1.06e-03	14	65	2	IPR023152
Domain	G_DYNAMIN_2	EHD1 EHD3	1.06e-03	14	65	2	PS51718
Domain	RasGAP	RASA1 IQGAP1	1.22e-03	15	65	2	PF00616
Domain	Diacylglycerol_kinase_cat_dom	DGKD DGKH	1.22e-03	15	65	2	IPR001206
Domain	Dynamin_GTPase	EHD1 EHD3	1.22e-03	15	65	2	IPR001401
Domain	Dynamin_N	EHD1 EHD3	1.22e-03	15	65	2	PF00350
Domain	RAS_GTPASE_ACTIV_1	RASA1 IQGAP1	1.22e-03	15	65	2	PS00509
Domain	DAGK_cat	DGKD DGKH	1.22e-03	15	65	2	PF00781
Domain	RAS_GTPASE_ACTIV_2	RASA1 IQGAP1	1.22e-03	15	65	2	PS50018
Domain	DAGK	DGKD DGKH	1.22e-03	15	65	2	PS50146
Domain	Dynamin_SF	EHD1 EHD3	1.22e-03	15	65	2	IPR022812
Domain	-	RASA1 IQGAP1	1.39e-03	16	65	2	1.10.506.10
Domain	ZF_DAG_PE_1	DGKD DGKH ARHGEF2	1.44e-03	64	65	3	PS00479
Domain	ZF_DAG_PE_2	DGKD DGKH ARHGEF2	1.44e-03	64	65	3	PS50081
Domain	C1	DGKD DGKH ARHGEF2	1.51e-03	65	65	3	SM00109
Domain	CH	MICALL1 SPTBN2 IQGAP1	1.51e-03	65	65	3	SM00033
Domain	NAD/diacylglycerol_kinase	DGKD DGKH	1.57e-03	17	65	2	IPR016064
Domain	PE/DAG-bd	DGKD DGKH ARHGEF2	1.57e-03	66	65	3	IPR002219
Domain	RasGAP_dom	RASA1 IQGAP1	1.76e-03	18	65	2	IPR001936
Domain	CH	MICALL1 SPTBN2 IQGAP1	1.86e-03	70	65	3	PF00307
Domain	-	MICALL1 SPTBN2 IQGAP1	1.94e-03	71	65	3	1.10.418.10
Domain	CH	MICALL1 SPTBN2 IQGAP1	2.10e-03	73	65	3	PS50021
Domain	CH-domain	MICALL1 SPTBN2 IQGAP1	2.27e-03	75	65	3	IPR001715
Domain	Spectrin/alpha-actinin	SESTD1 SPTBN2	5.53e-03	32	65	2	IPR018159
Domain	SPEC	SESTD1 SPTBN2	5.53e-03	32	65	2	SM00150
Domain	ARM-type_fold	DIAPH1 UTP20 CAB39L ATM SDAD1	6.49e-03	339	65	5	IPR016024
Pubmed	EHD3 Protein Is Required for Tubular Recycling Endosome Stabilization, and an Asparagine-Glutamic Acid Residue Pair within Its Eps15 Homology (EH) Domain Dictates Its Selective Binding to NPF Peptides.	MICALL1 EHD1 EHD3	2.61e-08	4	66	3	27189942
Pubmed	MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling.	MICALL1 EHD1 EHD3	1.30e-07	6	66	3	19864458
Pubmed	A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1.	SPIN2A SPIN2B SPIN4	1.30e-07	6	66	3	29061846
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	BAZ2B HECW2 KCNG4 TTC21A SPTBN2 UTP20 DGKH GRIK5 ATM CFAP44	1.23e-06	736	66	10	29676528
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DPP6 KCTD13 MAP1A PACSIN1 HECW2 TTC21A KIF1B SPTBN2 EHD1 ARHGEF2 CROCC IQGAP1 EHD3	2.45e-06	1431	66	13	37142655
Pubmed	Novel functions for the endocytic regulatory proteins MICAL-L1 and EHD1 in mitosis.	MICALL1 EHD1	3.55e-06	2	66	2	25287187
Pubmed	Identification and characterization of two splice variants of human diacylglycerol kinase eta.	DGKD DGKH	3.55e-06	2	66	2	12810723
Pubmed	The scaffold-protein IQGAP1 enhances and spatially restricts the actin-nucleating activity of Diaphanous-related formin 1 (DIAPH1).	DIAPH1 IQGAP1	3.55e-06	2	66	2	32005666
Pubmed	SUMOylation of EHD3 Modulates Tubulation of the Endocytic Recycling Compartment.	EHD1 EHD3	3.55e-06	2	66	2	26226295
Pubmed	Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression.	SPIN2A SPIN2B	3.55e-06	2	66	2	12145692
Pubmed	MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium.	MICALL1 EHD1	3.55e-06	2	66	2	31615969
Pubmed	Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport.	PACSIN1 EHD1	3.55e-06	2	66	2	30683896
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	COL23A1 DPP6 RASA1 VEZT TTC21A KIF1B CAB39L DGKH ZNF84 ZMIZ1 CROCC RIC1 EHD3	3.79e-06	1489	66	13	28611215
Pubmed	Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation.	DIAPH1 IQGAP1	1.06e-05	3	66	2	17620407
Pubmed	Regulation of Src trafficking and activation by the endocytic regulatory proteins MICAL-L1 and EHD1.	MICALL1 EHD1	1.06e-05	3	66	2	24481818
Pubmed	The tumor suppressor, TAX1BP2, is a novel substrate of ATM kinase.	ATM CROCC	1.06e-05	3	66	2	24240686
Pubmed	Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes.	EHD1 EHD3	1.06e-05	3	66	2	24019528
Pubmed	cPLA2α and EHD1 interact and regulate the vesiculation of cholesterol-rich, GPI-anchored, protein-containing endosomes.	MICALL1 EHD1	1.06e-05	3	66	2	22456504
Pubmed	CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis.	ARHGEF2 CCDC88B	1.06e-05	3	66	2	38200184
Pubmed	Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.	EHD1 EHD3	1.06e-05	3	66	2	25686250
Pubmed	Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method.	DGKD DGKH	1.06e-05	3	66	2	23949095
Pubmed	EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1.	EHD1 EHD3	1.06e-05	3	66	2	12121420
Pubmed	Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis.	MICALL1 EHD1	1.06e-05	3	66	2	23596323
Pubmed	Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins.	PCDHA9 PCDHA7	1.06e-05	3	66	2	27161523
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	DPP6 PCDHA9 EHD1 TRAPPC4 PCDHA7 RGS12 EHD3	1.19e-05	405	66	7	38187761
Pubmed	EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling.	PACSIN1 EHD1	2.12e-05	4	66	2	15930129
Pubmed	Interactions between EHD proteins and Rab11-FIP2: a role for EHD3 in early endosomal transport.	EHD1 EHD3	2.12e-05	4	66	2	16251358
Pubmed	C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH?	EHD1 EHD3	2.12e-05	4	66	2	16155252
Pubmed	Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function.	EHD1 EHD3	2.12e-05	4	66	2	29212907
Pubmed	DGKζ is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway.	DGKD IQGAP1	2.12e-05	4	66	2	22450320
Pubmed	Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans.	EHD1 EHD3	2.12e-05	4	66	2	17233914
Pubmed	EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins.	EHD1 EHD3	2.12e-05	4	66	2	10673336
Pubmed	Collapsin response mediator protein-2 (Crmp2) regulates trafficking by linking endocytic regulatory proteins to dynein motors.	MICALL1 EHD1	2.12e-05	4	66	2	20801876
Pubmed	Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane.	EHD1 EHD3	2.12e-05	4	66	2	15020713
Pubmed	Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes.	MICALL1 PACSIN1 DIAPH1	2.82e-05	31	66	3	19041431
Pubmed	EH domain proteins regulate cardiac membrane protein targeting.	EHD1 EHD3	3.53e-05	5	66	2	20489164
Pubmed	ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage.	PMS1 ATM	3.53e-05	5	66	2	15226443
Pubmed	Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function.	MICALL1 EHD1	3.53e-05	5	66	2	22284051
Pubmed	Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease.	PCDHA9 PCDHA7	3.53e-05	5	66	2	34888534
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	MICALL1 SESTD1 RPGRIP1L SCML1 TTC21A KIF1B TRAPPC4 PSMC6 CEP76 IQGAP1 EHD3	3.59e-05	1321	66	11	27173435
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	SPTBN2 PSMC6 CEP76 ATM SDAD1 RGS12 RIC1	4.39e-05	497	66	7	36774506
Pubmed	Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.	EHD1 EHD3	9.86e-05	8	66	2	17507647
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	UBE2Q1 EHD1 DIAPH1 PSMC6 ATM ARHGEF2 IQGAP1	1.18e-04	582	66	7	20467437
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	MICALL1 KIF1B SRPK1 ARHGEF2 RGS12	1.26e-04	255	66	5	15324660
Pubmed	STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.	KCTD13 STK25	1.27e-04	9	66	2	34518307
Pubmed	Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29.	EHD1 EHD3	1.27e-04	9	66	2	11423532
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	MICALL1 RBM25 KIF1B PSMC6 SRPK1 CAB39L ARHGEF2 SDAD1 IQGAP1 STK25	1.46e-04	1284	66	10	17353931
Pubmed	Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes.	DPP6 SRPK1	1.58e-04	10	66	2	10198174
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHA9 DIAPH1 PCDHA7	1.87e-04	58	66	3	30377227
Pubmed	The endocytic recycling regulatory protein EHD1 Is required for ocular lens development.	EHD1 EHD3	1.93e-04	11	66	2	26455409
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA9 PCDHA7	1.93e-04	11	66	2	9655502
Pubmed	Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.	DGKD DGKH	1.93e-04	11	66	2	17021016
Pubmed	A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.	UBE2Q1 KIF1B PSMC6	2.07e-04	60	66	3	20682791
Pubmed	Proteins of the CNR family are multiple receptors for Reelin.	PCDHA9 PCDHA7	2.31e-04	12	66	2	10612399
Pubmed	Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production.	CYP4F22 ALOXE3	2.31e-04	12	66	2	31356814
Pubmed	Autosomal Recessive Congenital Ichthyosis	CYP4F22 ALOXE3	2.73e-04	13	66	2	20301593
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	MAP1A SPTBN2 DIAPH1 SPIN2A SPIN4 SDAD1	3.60e-04	496	66	6	31343991
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA9 PCDHA7	3.67e-04	15	66	2	15640798
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHA9 PCDHA7	4.74e-04	17	66	2	29911975
Pubmed	Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.	PMS1 PCDHA9 KCNG4 PCDHA7	5.06e-04	193	66	4	22589738
Pubmed	Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.	DGKD DGKH	5.32e-04	18	66	2	24068962
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHA9 PCDHA7	5.32e-04	18	66	2	15570159
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHA9 PCDHA7	5.32e-04	18	66	2	10662547
Pubmed	PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier.	CYP4F22 ALOXE3	5.94e-04	19	66	2	28369476
Pubmed	Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women.	CCDC182 EHD3	5.94e-04	19	66	2	22675492
Pubmed	The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly.	CEP76 CROCC	5.94e-04	19	66	2	24421332
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	UTP20 SRPK1 ARHGEF2 IQGAP1	6.01e-04	202	66	4	33005030
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MICALL1 RBM25 KIF1B UTP20 ATM ARHGEF2 IQGAP1	6.56e-04	774	66	7	15302935
Pubmed	Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins.	SRPK1 IQGAP1	6.59e-04	20	66	2	22504172
Pubmed	Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.	DPP6 SCML1 UTP20 SPIN2B	7.07e-04	211	66	4	7566098
Pubmed	The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.	IL13 RASA1	7.28e-04	21	66	2	19578876
Pubmed	Tissue expression patterns identify mouse cilia genes.	CFAP52 TTC21A CROCC	8.22e-04	96	66	3	17971504
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	RBM25 KIF1B PSMC6 SRPK1 CEP76 ARHGEF2 IQGAP1	8.50e-04	809	66	7	32129710
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHA9 PCDHA7	9.53e-04	24	66	2	24698270
Pubmed	The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.	RASA1 IQGAP1	1.03e-03	25	66	2	15121898
Pubmed	Proteomic characterization of the human centrosome by protein correlation profiling.	CEP76 CROCC	1.12e-03	26	66	2	14654843
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	MICALL1 RPGRIP1L KIF1B SPTBN2 ARHGEF2 RGS12 IQGAP1	1.16e-03	853	66	7	28718761
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	MAP1A KIF1B EHD1 GRIK5 ARHGEF2 EHD3	1.16e-03	621	66	6	22794259
Pubmed	Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome.	SESTD1 ARHGEF2	1.21e-03	27	66	2	18685082
Pubmed	Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development.	EHD1 EHD3	1.30e-03	28	66	2	26884322
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHA9 PCDHA7	1.30e-03	28	66	2	15347688
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RBM25 SPTBN2 UTP20 SRPK1 ATM IQGAP1	1.50e-03	653	66	6	22586326
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	SPTBN2 EHD1 TRAPPC4 PSMC6 SRPK1 ATM ARHGEF2 SDAD1 IQGAP1	1.54e-03	1440	66	9	30833792
Pubmed	The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling.	MICALL1 HECW2	1.70e-03	32	66	2	31315048
Interaction	EHD3 interactions	MICALL1 KCTD13 EHD1 EHD3	3.52e-06	32	66	4	int:EHD3
Interaction	MICALL1 interactions	MICALL1 PACSIN1 HECW2 EHD1 EHD3	1.65e-05	97	66	5	int:MICALL1
Interaction	TTC21A interactions	KCTD13 TTC21A CEP76	2.64e-05	18	66	3	int:TTC21A
Interaction	SCP2D1 interactions	EHD1 EHD3	3.16e-05	3	66	2	int:SCP2D1
Interaction	ARHGAP26 interactions	LMAN1L RBM25 KCTD13 SRPK1 ARHGEF2	4.60e-05	120	66	5	int:ARHGAP26
Interaction	PPP2R1A interactions	PMS1 KCTD13 PACSIN1 EHD1 PSMC6 DGKH ATM ARHGEF2 IQGAP1 STK25	5.69e-05	665	66	10	int:PPP2R1A
Interaction	KCNQ3 interactions	DPP6 KCTD13 TRAPPC4	6.46e-05	24	66	3	int:KCNQ3
Interaction	RNF123 interactions	PMS1 BAZ2B HECW2 KCNG4 TTC21A SPTBN2 UTP20 DGKH GRIK5 ATM CFAP44	6.86e-05	824	66	11	int:RNF123
Cytoband	Xp11.1	SPIN2A SPIN2B	1.22e-05	4	66	2	Xp11.1
Cytoband	5q31	IL13 PCDHA9 DIAPH1 PCDHA7	2.39e-05	115	66	4	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	IL13 PCDHA9 DIAPH1 PCDHA7	9.14e-04	298	66	4	chr5q31
Cytoband	15q22.31	TIPIN SNX22	1.69e-03	42	66	2	15q22.31
GeneFamily	Tudor domain containing\|Spindlin family	SPIN2A SPIN2B SPIN4	1.34e-07	5	44	3	1089
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASA1 KIF1B SPTBN2 DGKD DGKH ARHGEF2	1.00e-05	206	44	6	682
GeneFamily	Sterile alpha motif domain containing	SCMH1 SCML1 DGKD DGKH	6.13e-05	88	44	4	760
GeneFamily	Tudor domain containing	SPIN2A SPIN2B SPIN4	9.86e-05	37	44	3	780
GeneFamily	EF-hand domain containing\|Diacylglycerol kinases	DGKD DGKH	2.57e-04	10	44	2	1178
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RPGRIP1L HECW2	3.46e-03	36	44	2	823
ToppCell	LPS-antiTNF-Endothelial-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DPP6 UTP20 ATP11C ALOXE3 CFAP44	2.39e-06	144	66	5	75b16adfbe84f69376e6566d531ba7919d5c5192
ToppCell	Ciliated_cells-B-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	RPGRIP1L CFAP52 MAP1A CFAP44 LRRC9	7.50e-06	182	66	5	e93968f800bfeb258e4e834fc8bf92d1cb72cd73
Drug	Levodopa [59-92-7]; Up 200; 20.2uM; HL60; HG-U133A	RBM25 KCTD13 PACSIN1 SCML1 EHD1 SRPK1 DGKD	1.65e-06	197	66	7	1972_UP
Drug	lithium indium	SPIN2A SPIN2B	8.28e-06	2	66	2	CID011116062
Drug	scandium phosphate	SPIN2A SPIN2B	8.28e-06	2	66	2	CID006365269
Drug	rubidium nitrate	SPIN2A SPIN2B	8.28e-06	2	66	2	CID000025731
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	MICALL1 PMS1 KCTD13 CEP76 ATM CFAP44	1.87e-05	190	66	6	5586_DN
Drug	(-)-Isoproterenol hydrochloride [5984-95-2]; Down 200; 16.2uM; PC3; HT_HG-U133A	PCDHA9 KCTD13 VEZT SPTBN2 CROCC EHD3	2.17e-05	195	66	6	4495_DN
Drug	Trapidil [15421-84-8]; Down 200; 19.4uM; MCF7; HT_HG-U133A	METTL25B MAP1A GRIK5 ATM CFAP44 STK25	2.36e-05	198	66	6	6515_DN
Disease	Congenital ichthyosis of skin	CYP4F22 ALOXE3	2.52e-04	11	64	2	cv:C0020758
Disease	Congenital Nonbullous Ichthyosiform Erythroderma	CYP4F22 ALOXE3	2.52e-04	11	64	2	C0079154
Disease	psoriasis vulgaris	IL13 ZMIZ1 CCDC88B	3.20e-04	61	64	3	EFO_1001494
Disease	gamma-glutamylphenylalanine measurement	DPP6 ARHGEF2	4.77e-04	15	64	2	EFO_0021142
Disease	psoriasis, type 2 diabetes mellitus	IL13 ZMIZ1 CCDC88B	5.88e-04	75	64	3	EFO_0000676, MONDO_0005148
Disease	Feeding difficulties	TRAPPC4 ZMIZ1	6.93e-04	18	64	2	C0232466
Disease	blood aluminium measurement	DPP6 BAZ2B	8.58e-04	20	64	2	EFO_0007575
Disease	visceral adipose tissue measurement, body mass index	PCDHA9 KCNG4 PCDHA7	9.06e-04	87	64	3	EFO_0004340, EFO_0004765
Disease	lymphocyte count	LMAN1L IL13 PACSIN1 KIF1B CYP4F22 DGKD GRIK5 ATM ZMIZ1 IQGAP1	1.15e-03	1464	64	10	EFO_0004587
Disease	antiphospholipid antibody measurement	COL23A1 SESTD1	1.35e-03	25	64	2	EFO_0005200
Disease	leprosy	RPGRIP1L CROCC CCDC88B	1.47e-03	103	64	3	EFO_0001054
Disease	Hereditary non-polyposis colorectal cancer syndrome	PMS1 ATM	1.57e-03	27	64	2	C1112155
Disease	gamma-glutamyltyrosine measurement	ZMIZ1 ARHGEF2	1.57e-03	27	64	2	EFO_0021144
Disease	Hereditary Nonpolyposis Colorectal Cancer	PMS1 ATM	1.81e-03	29	64	2	C1333990
Disease	1,5 anhydroglucitol measurement	PCDHA9 PCDHA7	1.81e-03	29	64	2	EFO_0008009

Protein segments in the cluster

Peptide	Gene	Start	Entry
IELFDKLALRFHGRL	KCTD13	196	Q8WZ19
RQSLKLLGELILDRH	CAB39L	226	Q9H9S4
LKQEIHELRGRLERL	EGFL8	211	Q99944
ELEGLLVRHRDLKAN	CCDC88B	1091	A6NC98
DLKALLKVLHLRGIR	BAZ2B	1726	Q9UIF8
EELLRRKLIHDGCLL	ARHGEF2	466	Q92974
IRGEAFDRHLLGLKL	CRAT	511	P43155
LLHEIIRKRDNALEL	ANGPTL2	141	Q9UKU9
QLRLLVSEHRKDLGL	CEP76	531	Q8TAP6
EGLASLLDILKRLHD	DIAPH1	186	O60610
VALFELALHLREKRL	CFAP44	1546	Q96MT7
LALHLREKRLDIEEA	CFAP44	1551	Q96MT7
ARLHEKGVLLEIEDL	IQGAP1	1566	P46940
LRALRLLHDLQIGEK	RBM25	141	P49756
LRKLLDREETPELHL	PCDHA9	196	Q9Y5H5
LLRIFLHEKLESLLL	RASA1	756	P20936
HARRLLEDVRLKDLG	RIC1	1066	Q4ADV7
ALHLEENRLRELGKL	LRRC9	1276	Q6ZRR7
LKLIIRRDHLLEDAF	HECW2	1216	Q9P2P5
LRKLLDREETPELHL	PCDHA7	196	Q9UN72
HKIENFRELRILILD	LRRD1	366	A4D1F6
ILEGLEKLRHLDFLR	MAP1A	276	P78559
EDRFLRLHDENILLK	RPGRIP1L	51	Q68CZ1
EKTRHFLLLRERLGD	KIF1B	1506	O60333
LGELLLLRVHKERYA	ALOXE3	61	Q9BYJ1
LFDLEETLGRHRRIL	LMAN1L	306	Q9HAT1
LRKLEELEELAKLHR	KCNG4	166	Q8TDN1
RELLARLSLHKGKIE	CFAP52	101	Q8N1V2
HLERLLREKLDGLAK	COL23A1	91	Q86Y22
ILERHHLEFGKTLLR	PDE6A	626	P16499
DLLLHLKKLFREGRF	IL13	131	P35225
DALEHRGVLLEEKLR	MICALL1	696	Q8N3F8
HEIRRLGELVKKLSD	METTL25B	136	Q96FB5
ELLHLERRDLKDLGI	DGKH	1181	Q86XP1
REHCKRLEDLLLDRG	CCDC182	126	A6NF36
RLVFLKEVLLDIKRH	PACSIN1	241	Q9BY11
LEGLKDLRRQLELHK	ATM	1611	Q13315
LLKRAKEEVGLLREH	ATM	2416	Q13315
LDHARGLELKLEAAR	CROCC	1381	Q5TZA2
LLHLERRDLKDLGVT	DGKD	1176	Q16760
KLLHEVRRRLGLLEE	DPP6	671	P42658
LLRLEELVRGFLISK	GRIK5	171	Q16478
RVDRIILLFDAHKLD	EHD1	181	Q9H4M9
RVEEALLFKRLLENH	PMS1	751	P54277
HRLVVLEKELLRDHL	CCDC153	31	Q494R4
DRLLHLLGLEKTAFR	CYP4F22	6	Q6NT55
EIIHRSLLEKLRKGL	UTP20	1516	O75691
LFRSHEIDGKALLLL	SCML1	281	Q9UN30
LDLLLKLHDERVLVA	TRAPPC4	36	Q9Y296
LELHRDERVLSLKIL	SPIN2A	96	Q99865
GELLSLRDIERLHKK	SDAD1	591	Q9NVU7
RDEDHIALIIELLGK	SRPK1	561	Q96SB4
RVDRIILLFDAHKLD	EHD3	181	Q9NZN3
LREILKGLDYLHSER	STK25	121	O00506
FRKHEIDGKALLLLR	SCMH1	616	Q96GD3
LLDALLKTHIRLGDD	SESTD1	516	Q86VW0
DRLHELLIEYRKKLL	ATP11C	716	Q8NB49
RGLLRKEDLVLPEFL	RGS12	1206	O14924
KRLGHELELRGKRLE	SPTBN2	1571	O15020
GLELHRDKRVLALEI	SPIN4	86	Q56A73
LELHRDERVLSLKIL	SPIN2B	96	Q9BPZ2
FLVLHKLIDLLRRSG	TTC21A	991	Q8NDW8
EVPKELLEFLRLRHF	SNX22	96	Q96L94
DLDGLILKHHLDLLI	ZNF84	131	P51523
LLEHKEIDGRLKELR	PSMC6	16	P62333
DLLHKLDIGFRLDSL	VEZT	81	Q9HBM0
KRIRLDLPILHEDFV	TIPIN	141	Q9BVW5
EELGRLLLLRHQKSR	ZMIZ1	101	Q9ULJ6
LRRELKLLESIFHRG	UBE2Q1	41	Q7Z7E8