Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9	2.31e-11	37	32	6	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9	2.74e-11	38	32	6	GO:0070001
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9	5.43e-05	430	32	6	GO:0004175
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-8 ERVK-6	1.36e-04	11	32	2	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-8 ERVK-6	2.24e-04	14	32	2	GO:0003964
GeneOntologyMolecularFunction	zinc ion binding	ERVK-8 ERVK-6 LHX1 ERVK-19 LHX5 ERVK-21 ERVK-9	4.35e-04	891	32	7	GO:0008270
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-8 ERVK-6	5.13e-04	21	32	2	GO:0035613
GeneOntologyMolecularFunction	peptidase activity	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9	5.28e-04	654	32	6	GO:0008233
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-8 ERVK-6	1.60e-03	37	32	2	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-8 ERVK-6	1.69e-03	38	32	2	GO:0034061
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-8 ERVK-6 LHX1 ERVK-19 LHX5 ERVK-21 ERVK-9	2.36e-03	1189	32	7	GO:0046914
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-8 ERVK-6	2.46e-03	46	32	2	GO:0016893
GeneOntologyMolecularFunction	structural molecule activity	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9	2.60e-03	891	32	6	GO:0005198
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-8 ERVK-6	7.10e-03	79	32	2	GO:0004521
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-8 ERVK-6 RSF1	8.36e-03	262	32	3	GO:0140097
GeneOntologyBiologicalProcess	cell-cell fusion	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9	2.29e-07	85	33	5	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9	2.29e-07	85	33	5	GO:0000768
GeneOntologyBiologicalProcess	syncytium formation	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9	2.88e-07	89	33	5	GO:0006949
GeneOntologyBiologicalProcess	spinal cord association neuron differentiation	LHX1 LHX5 GDF7	1.34e-06	14	33	3	GO:0021527
GeneOntologyBiologicalProcess	cerebellar Purkinje cell-granule cell precursor cell signaling	LHX1 LHX5	2.48e-06	2	33	2	GO:0021937
GeneOntologyBiologicalProcess	dorsal spinal cord development	LHX1 LHX5 GDF7	5.63e-06	22	33	3	GO:0021516
GeneOntologyBiologicalProcess	positive regulation of cerebellar granule cell precursor proliferation	LHX1 LHX5	5.19e-05	7	33	2	GO:0021940
GeneOntologyBiologicalProcess	mRNA transport	ERVK-6 ERVK-21 YTHDC1 ERVK-16	8.18e-05	145	33	4	GO:0051028
GeneOntologyBiologicalProcess	viral process	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9 RSF1	8.30e-05	464	33	6	GO:0016032
GeneOntologyBiologicalProcess	regulation of cerebellar granule cell precursor proliferation	LHX1 LHX5	1.11e-04	10	33	2	GO:0021936
GeneOntologyBiologicalProcess	cell differentiation in spinal cord	LHX1 LHX5 GDF7	1.39e-04	63	33	3	GO:0021515
GeneOntologyBiologicalProcess	RNA transport	ERVK-6 ERVK-21 YTHDC1 ERVK-16	1.69e-04	175	33	4	GO:0050658
GeneOntologyBiologicalProcess	nucleic acid transport	ERVK-6 ERVK-21 YTHDC1 ERVK-16	1.69e-04	175	33	4	GO:0050657
GeneOntologyBiologicalProcess	establishment of RNA localization	ERVK-6 ERVK-21 YTHDC1 ERVK-16	1.80e-04	178	33	4	GO:0051236
GeneOntologyBiologicalProcess	DNA integration	ERVK-8 ERVK-6	1.91e-04	13	33	2	GO:0015074
GeneOntologyBiologicalProcess	cell proliferation in external granule layer	LHX1 LHX5	2.94e-04	16	33	2	GO:0021924
GeneOntologyBiologicalProcess	cerebellar granule cell precursor proliferation	LHX1 LHX5	2.94e-04	16	33	2	GO:0021930
GeneOntologyBiologicalProcess	cell proliferation in hindbrain	LHX1 LHX5	3.74e-04	18	33	2	GO:0021534
GeneOntologyBiologicalProcess	cerebellar Purkinje cell differentiation	LHX1 LHX5	3.74e-04	18	33	2	GO:0021702
GeneOntologyBiologicalProcess	RNA localization	ERVK-6 ERVK-21 YTHDC1 ERVK-16	3.84e-04	217	33	4	GO:0006403
GeneOntologyBiologicalProcess	anatomical structure formation involved in morphogenesis	ERVK-8 ERVK-6 LHX1 ERVK-19 LHX5 ERVK-21 ERVK-9 NRXN3 GDF7	3.98e-04	1483	33	9	GO:0048646
GeneOntologyBiologicalProcess	cerebellar Purkinje cell layer formation	LHX1 LHX5	4.63e-04	20	33	2	GO:0021694
GeneOntologyBiologicalProcess	nucleobase-containing compound transport	ERVK-6 ERVK-21 YTHDC1 ERVK-16	6.44e-04	249	33	4	GO:0015931
GeneOntologyBiologicalProcess	cerebellar Purkinje cell layer morphogenesis	LHX1 LHX5	7.28e-04	25	33	2	GO:0021692
GeneOntologyBiologicalProcess	spinal cord development	LHX1 LHX5 GDF7	9.00e-04	119	33	3	GO:0021510
Domain	HTH_motif	LHX1 LHX5	4.45e-03	69	27	2	IPR000047
Domain	LIM	LHX1 LHX5	4.45e-03	69	27	2	PF00412
Domain	-	LHX1 LHX5	4.57e-03	70	27	2	2.10.110.10
Domain	LIM_DOMAIN_2	LHX1 LHX5	4.70e-03	71	27	2	PS50023
Domain	Znf_LIM	LHX1 LHX5	4.70e-03	71	27	2	IPR001781
Domain	LIM_DOMAIN_1	LHX1 LHX5	4.70e-03	71	27	2	PS00478
Domain	LIM	LHX1 LHX5	4.70e-03	71	27	2	SM00132
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9	7.01e-13	12	36	5	14557543
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9 ERVK-16	6.57e-12	94	36	7	21542922
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-19 ERVK-9 ERVK-16	1.45e-11	6	36	4	15063128
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-19 ERVK-21	1.02e-08	5	36	3	12629516
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-19 ERVK-21	1.22e-07	10	36	3	12970426
Pubmed	Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord.	LHX1 LHX5 GDF7	2.89e-07	13	36	3	11877374
Pubmed	The roof plate regulates cerebellar cell-type specification and proliferation.	LHX1 LHX5 GDF7	5.65e-07	16	36	3	16790481
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-21 ERVK-25 ERVK-9	8.22e-07	18	36	3	18664271
Pubmed	Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip.	LHX1 LHX5 GDF7	8.22e-07	18	36	3	31869353
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	1.04e-06	2	36	2	9060628
Pubmed	The LIM-homeodomain gene family in the developing Xenopus brain: conservation and divergences with the mouse related to the evolution of the forebrain.	LHX1 LHX5	1.04e-06	2	36	2	11567052
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	1.04e-06	2	36	2	9460924
Pubmed	Molecular basis for angiotensin II-induced increase of chloride/bicarbonate exchange in the myocardium.	PRKCE SLC4A3	1.04e-06	2	36	2	11739292
Pubmed	Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons.	LHX1 LHX5 GDF7	1.55e-06	22	36	3	17150208
Pubmed	Cbln1 regulates axon growth and guidance in multiple neural regions.	LHX1 LHX5 NRXN3	1.55e-06	22	36	3	36395107
Pubmed	FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation.	LHX1 LHX5 GDF7	1.78e-06	23	36	3	19668217
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-19	3.12e-06	3	36	2	10516026
Pubmed	Investigation of tissue-specific expression and functions of MLF1-IP during development and in the immune system.	CENPU LHX1	3.12e-06	3	36	2	23724000
Pubmed	Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin.	LHX1 LHX5	3.12e-06	3	36	2	28516904
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9	3.12e-06	3	36	2	9971820
Pubmed	Similarities and differences in the forebrain expression of Lhx1 and Lhx5 between chicken and mouse: Insights for understanding telencephalic development and evolution.	LHX1 LHX5	3.12e-06	3	36	2	20589911
Pubmed	The transcriptional control of trunk neural crest induction, survival, and delamination.	LHX1 LHX5 GDF7	5.96e-06	34	36	3	15691760
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-19	6.24e-06	4	36	2	7983737
Pubmed	Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limb.	LHX1 LHX5	6.24e-06	4	36	2	10943837
Pubmed	Tempo and mode of ERV-K evolution in human and chimpanzee genomes.	ERVK-6 ERVK-16	1.04e-05	5	36	2	16830071
Pubmed	Expression of murine Lhx5 suggests a role in specifying the forebrain.	LHX1 LHX5	1.04e-05	5	36	2	9022063
Pubmed	Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling.	LHX1 LHX5	1.04e-05	5	36	2	10433919
Pubmed	Differential expression of LIM-homeodomain factors in Cajal-Retzius cells of primates, rodents, and birds.	LHX1 LHX5	1.04e-05	5	36	2	19923199
Pubmed	Homeodomain transcription factors in the development of subsets of hindbrain reticulospinal neurons.	LHX1 LHX5	1.04e-05	5	36	2	15607939
Pubmed	Tace/ADAM17 is a bi-directional regulator of axon guidance that coordinates distinct Frazzled and Dcc receptor signaling outputs.	LHX1 LHX5	1.56e-05	6	36	2	36476876
Pubmed	Differential expression of LIM-homeodomain genes in the embryonic murine brain.	LHX1 LHX5	1.56e-05	6	36	2	8817562
Pubmed	Dehydroepiandrosterone biosynthesis, role, and mechanism of action in the developing neural tube.	LHX1 LHX5	2.18e-05	7	36	2	22649409
Pubmed	A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord.	LHX1 LHX5	2.18e-05	7	36	2	24924197
Pubmed	Neurogenin1 expression in cell lineages of the cerebellar cortex in embryonic and postnatal mice.	LHX1 LHX5	2.18e-05	7	36	2	19924827
Pubmed	Prrxl1 is required for the generation of a subset of nociceptive glutamatergic superficial spinal dorsal horn neurons.	LHX1 LHX5	2.18e-05	7	36	2	20503365
Pubmed	Ectopic HOXA5 expression results in abnormal differentiation, migration and p53-independent cell death of superficial dorsal horn neurons.	LHX1 LHX5	2.91e-05	8	36	2	16139370
Pubmed	The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo.	LHX1 LHX5	2.91e-05	8	36	2	8069910
Pubmed	The expression profile of the tumor suppressor gene Lzts1 suggests a role in neuronal development.	LHX1 LHX5	2.91e-05	8	36	2	22419569
Pubmed	Dynamic expression of murine HOXA5 protein in the central nervous system.	LHX1 LHX5	2.91e-05	8	36	2	15922675
Pubmed	Purkinje cells originate from cerebellar ventricular zone progenitors positive for Neph3 and E-cadherin.	LHX1 LHX5	3.73e-05	9	36	2	20004188
Pubmed	The Onecut transcription factor HNF-6 contributes to proper reorganization of Purkinje cells during postnatal cerebellum development.	LHX1 LHX5	3.73e-05	9	36	2	23669529
Pubmed	Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme.	LHX1 LHX5	3.73e-05	9	36	2	16018995
Pubmed	LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum.	LHX1 LHX5	3.73e-05	9	36	2	17664423
Pubmed	Newly identified patterns of Pax2 expression in the developing mouse forebrain.	LHX1 LHX5	3.73e-05	9	36	2	18700968
Pubmed	Molecular markers of neuronal progenitors in the embryonic cerebellar anlage.	LHX1 LHX5	3.73e-05	9	36	2	17122047
Pubmed	Sequential roles for Mash1 and Ngn2 in the generation of dorsal spinal cord interneurons.	LHX1 LHX5	4.66e-05	10	36	2	15901662
Pubmed	Comparative analysis of proneural gene expression in the embryonic cerebellum.	LHX1 LHX5	4.66e-05	10	36	2	18498101
Pubmed	Tlx3 Exerts Direct Control in Specifying Excitatory Over Inhibitory Neurons in the Dorsal Spinal Cord.	LHX1 LHX5	4.66e-05	10	36	2	33996801
Pubmed	Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum.	LHX1 LHX5	4.66e-05	10	36	2	20809939
Pubmed	DRG11 immunohistochemical expression during embryonic development in the mouse.	LHX1 LHX5	4.66e-05	10	36	2	17676639
Pubmed	Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons.	LHX1 LHX5	4.66e-05	10	36	2	11502254
Pubmed	Hoxb1 controls anteroposterior identity of vestibular projection neurons.	LHX1 LHX5	5.70e-05	11	36	2	22485187
Pubmed	Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation.	LHX1 LHX5	5.70e-05	11	36	2	11944941
Pubmed	Pax6 is required intrinsically by thalamic progenitors for the normal molecular patterning of thalamic neurons but not the growth and guidance of their axons.	LHX1 LHX5	5.70e-05	11	36	2	26520399
Pubmed	The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression.	LHX1 LHX5	5.70e-05	11	36	2	28165338
Pubmed	Loss of Ptf1a Leads to a Widespread Cell-Fate Misspecification in the Brainstem, Affecting the Development of Somatosensory and Viscerosensory Nuclei.	LHX1 LHX5	6.83e-05	12	36	2	26937009
Pubmed	LIM-homeobox gene Lhx5 is required for normal development of Cajal-Retzius cells.	LHX1 LHX5	6.83e-05	12	36	2	20685998
Pubmed	Analysis of early ventral telencephalic defects in mice lacking functional Gli3 protein.	LHX1 LHX5	6.83e-05	12	36	2	19048639
Pubmed	The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord.	LHX1 LHX5	6.83e-05	12	36	2	12062039
Pubmed	Expression of Dlx and Lhx family homeobox genes in fetal thymus and thymocytes.	LHX1 LHX5	6.83e-05	12	36	2	15053981
Pubmed	PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates.	LHX1 LHX5	6.83e-05	12	36	2	15229603
Pubmed	Population-specific regulation of Chmp2b by Lbx1 during onset of synaptogenesis in lateral association interneurons.	LHX1 LHX5	6.83e-05	12	36	2	23284619
Pubmed	Dynamic spatiotemporal expression of LIM genes and cofactors in the embryonic and postnatal cerebral cortex.	LHX1 LHX5	6.83e-05	12	36	2	12619132
Pubmed	Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus.	LHX1 LHX5	8.07e-05	13	36	2	12799141
Pubmed	Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons.	LHX1 LHX5	8.07e-05	13	36	2	9315901
Pubmed	Characterization of Olig2 expression during cerebellar development.	LHX1 LHX5	8.07e-05	13	36	2	24594479
Pubmed	Onecut transcription factors are required for the second phase of development of the A13 dopaminergic nucleus in the mouse.	LHX1 LHX5	8.07e-05	13	36	2	22102297
Pubmed	Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord.	LHX1 LHX5	8.07e-05	13	36	2	22159578
Pubmed	Pax6 regulates the identity of embryonic diencephalic neurons.	LHX1 LHX5	8.07e-05	13	36	2	11161479
Pubmed	Loss of apoptosis-inducing factor results in cell-type-specific neurogenesis defects.	LHX1 LHX5	8.07e-05	13	36	2	18463247
Pubmed	Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord.	LHX1 LHX5	8.07e-05	13	36	2	17166926
Pubmed	Genetic dissection of Gata2 selective functions during specification of V2 interneurons in the developing spinal cord.	LHX1 LHX5	8.07e-05	13	36	2	25369423
Pubmed	Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus.	LHX1 LHX5	8.07e-05	13	36	2	16055717
Pubmed	Identification of a novel transcriptional corepressor, Corl2, as a cerebellar Purkinje cell-selective marker.	LHX1 LHX5	8.07e-05	13	36	2	18522874
Pubmed	Combinatorial expression patterns of LIM-homeodomain and other regulatory genes parcellate developing thalamus.	LHX1 LHX5	8.07e-05	13	36	2	11306624
Pubmed	Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn.	LHX1 LHX5	9.41e-05	14	36	2	16291784
Pubmed	GABAergic and glutamatergic identities of developing midbrain Pitx2 neurons.	LHX1 LHX5	9.41e-05	14	36	2	21246650
Pubmed	Corl1, a novel neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor Lbx1.	LHX1 LHX5	9.41e-05	14	36	2	15528197
Pubmed	Pituitary adenylyl cyclase-activating peptide counteracts hedgehog-dependent motor neuron production in mouse embryonic stem cell cultures.	LHX1 LHX5	9.41e-05	14	36	2	21674568
Pubmed	Origin of a Non-Clarke's Column Division of the Dorsal Spinocerebellar Tract and the Role of Caudal Proprioceptive Neurons in Motor Function.	LHX1 LHX5	9.41e-05	14	36	2	26527010
Pubmed	Distinct Activities of Tfap2A and Tfap2B in the Specification of GABAergic Interneurons in the Developing Cerebellum.	LHX1 LHX5	9.41e-05	14	36	2	28912684
Pubmed	The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age.	LHX1 LHX5	1.08e-04	15	36	2	18076286
Pubmed	Characterization of the Gbx1-/- mouse mutant: a requirement for Gbx1 in normal locomotion and sensorimotor circuit development.	LHX1 LHX5	1.08e-04	15	36	2	23418536
Pubmed	Characterization of Foxp2-expressing cells in the developing spinal cord.	LHX1 LHX5	1.08e-04	15	36	2	19463901
Pubmed	Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology.	LHX1 LHX5	1.08e-04	15	36	2	33899734
Pubmed	AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons.	LHX1 LHX5	1.08e-04	15	36	2	15240886
Pubmed	dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development.	LHX1 LHX5	1.08e-04	15	36	2	16690754
Pubmed	Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain.	LHX1 LHX5	1.08e-04	15	36	2	17475798
Pubmed	BARHL2 transcription factor regulates the ipsilateral/contralateral subtype divergence in postmitotic dI1 neurons of the developing spinal cord.	LHX1 LHX5	1.24e-04	16	36	2	22307612
Pubmed	Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons.	LHX1 LHX5	1.24e-04	16	36	2	12787506
Pubmed	Loss of Wnt8b has no overt effect on hippocampus development but leads to altered Wnt gene expression levels in dorsomedial telencephalon.	LHX1 LHX5	1.24e-04	16	36	2	19890917
Pubmed	Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools.	LHX1 LHX5	1.24e-04	16	36	2	19850875
Pubmed	Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification.	LHX1 GDF7	1.24e-04	16	36	2	10693795
Pubmed	The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development.	LHX1 LHX5	1.24e-04	16	36	2	28603487
Pubmed	Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1.	LHX1 LHX5	1.24e-04	16	36	2	11239429
Pubmed	Otx2 Requires Lmx1b to Control the Development of Mesodiencephalic Dopaminergic Neurons.	LHX1 LHX5	1.24e-04	16	36	2	26444681
Pubmed	Spatially restricted and developmentally dynamic expression of engrailed genes in multiple cerebellar cell types.	LHX1 LHX5	1.40e-04	17	36	2	21431469
Pubmed	Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance.	LHX1 LHX5	1.40e-04	17	36	2	21316586
Pubmed	Identification and subclassification of new Atoh1 derived cell populations during mouse spinal cord development.	LHX1 LHX5	1.40e-04	17	36	2	19135992
Pubmed	Contribution of Hox genes to the diversity of the hindbrain sensory system.	LHX1 LHX5	1.40e-04	17	36	2	14960494
GeneFamily	LIM class homeoboxes	LHX1 LHX5	6.86e-05	12	19	2	522
GeneFamily	RNA binding motif containing	RNPS1 ENOX2	2.07e-02	213	19	2	725
Coexpression	HEVNER_CORTEX_CAJAL_RETZIUS_CELLS	LHX1 LHX5	3.30e-05	8	29	2	MM394
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LHX1 PRKCE NRXN3 ST6GALNAC6 BHLHA9	1.25e-07	186	29	5	d1d01ce46e62944aa9864eda47e8401b5f0d2bdc
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-CR\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LHX1 LHX5 GPER1	2.14e-05	83	29	3	1ab68323518adc7fd0a459b41fad12d60f97eb5c
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-CR-CR_Lhx5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LHX1 LHX5 GPER1	2.14e-05	83	29	3	75b27d91a4473286f4b40027e96ac5246f5abe5b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LHX1 CBX6 PANK1	1.35e-04	154	29	3	dcbc6705e91ec744801b621e5d0733a78a7a90ca
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LHX1 LHX5 NRXN3	1.83e-04	171	29	3	99176a932569fa1c7e1c01009684f5a65244b96e
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CENPU SAMD1 ANKRD54	1.86e-04	172	29	3	eba1568d4307e91c94fc616549057cbed8df5840
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CENPU GDF7 GPER1	1.90e-04	173	29	3	9f892d756d05e573af018db64edb130ff187ad47
ToppCell	3'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRAC2 GPER1 EGR4	2.10e-04	179	29	3	878b15ea62e3405682a538f79f58d74b9cd3f398
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCE NRXN3 BHLHA9	2.38e-04	187	29	3	e04a84989d624378141042768383b9c846901f2d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCE NRXN3 BHLHA9	2.38e-04	187	29	3	24cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCE NRXN3 BHLHA9	2.38e-04	187	29	3	2f153b203fe79f206319603cf94d3a03ab49a05d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LHX1 PRKCE NRXN3	2.46e-04	189	29	3	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	Hippocampus-Neuronal-Excitatory\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PRKCE EGR4 BHLHA9	2.46e-04	189	29	3	4b90d181eb0a42814eeb23bc82e52fd3a12392a7
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LHX1 NRXN3 EGR4	2.46e-04	189	29	3	3d838da870623a6a278ddc8e6cedca85d9877e50
ToppCell	Entopeduncular-Neuronal-Inhibitory\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	LHX1 LHX5 NRXN3	2.54e-04	191	29	3	73dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	LHX1 LHX5 NRXN3	2.54e-04	191	29	3	5d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCE NRXN3 SLC4A3	2.62e-04	193	29	3	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCE NRXN3 SLC4A3	2.62e-04	193	29	3	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCE NRXN3 SLC4A3	2.62e-04	193	29	3	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LHX1 PRKCE NRXN3	2.62e-04	193	29	3	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	normal_Lung-Myeloid_cells-CD141+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	GDF7 GPER1 CBX6	2.66e-04	194	29	3	d21461682fa755f588afe073abb6a777f339c4cc
ToppCell	IPF-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	PRKCE NRXN3 GPER1	2.74e-04	196	29	3	8f0f72ead06abe02b575e443552eacc2151077ef
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CENPU LHX5 RNPS1	2.78e-04	197	29	3	2b58ac5d70e1ebd9bf9f2b60ee8079337a723658
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	LHX1 LHX5 NRXN3	2.90e-04	200	29	3	ac0e023dbb383bbc46c5cc525431778be8f7ef46
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuronal\|10w / Sample Type, Dataset, Time_group, and Cell type.	LHX1 LHX5 NRXN3	2.90e-04	200	29	3	979258173b82f37aeaaedd53b4a527da1dbe1b80
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Interneuron\|6m / Sample Type, Dataset, Time_group, and Cell type.	LHX1 LHX5 NRXN3	2.90e-04	200	29	3	274871d632bbbe03720726a59ab3ec6d5fa0da11
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Neuronal-Interneuron\|2m / Sample Type, Dataset, Time_group, and Cell type.	LHX1 LHX5 NRXN3	2.90e-04	200	29	3	08bee924a2654e05df3b39e8a51f93c8b3472175
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-1m-Neuronal-Interneuron\|1m / Sample Type, Dataset, Time_group, and Cell type.	LHX1 LHX5 NRXN3	2.90e-04	200	29	3	fc839e9c33ea1d4ee0f42f21fd32a54e7cbe1f5a
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-1m-Neuronal-Intermediate\|1m / Sample Type, Dataset, Time_group, and Cell type.	LHX1 LHX5 RSF1	2.90e-04	200	29	3	805f50236113713b02f77aa5e208efb3b3b959d5
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Interneuron\|10w / Sample Type, Dataset, Time_group, and Cell type.	LHX1 LHX5 NRXN3	2.90e-04	200	29	3	f5c63ef52bd7a898cf009b8bf9b2f7f4890d1c9b
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	PRKCE NRXN3 SLC4A3	2.90e-04	200	29	3	bad32a95b759fad509401b07bc96a56687c2a592
Disease	cerebral amyloid deposition measurement	PRKCE NRXN3	3.17e-03	95	26	2	EFO_0007707
Disease	Organic Mental Disorders, Substance-Induced	PRKCE NRXN3	4.60e-03	115	26	2	C0029231
Disease	Drug Use Disorders	PRKCE NRXN3	4.60e-03	115	26	2	C0013222
Disease	Drug Dependence	PRKCE NRXN3	4.60e-03	115	26	2	C1510472
Disease	Drug habituation	PRKCE NRXN3	4.60e-03	115	26	2	C0013170
Disease	Substance Dependence	PRKCE NRXN3	4.60e-03	115	26	2	C0038580
Disease	Substance Use Disorders	PRKCE NRXN3	4.60e-03	115	26	2	C0038586
Disease	Substance-Related Disorders	PRKCE NRXN3	4.60e-03	115	26	2	C0236969
Disease	Prescription Drug Abuse	PRKCE NRXN3	4.60e-03	115	26	2	C4316881
Disease	Drug abuse	PRKCE NRXN3	4.60e-03	115	26	2	C0013146
Disease	Substance abuse problem	PRKCE NRXN3	4.68e-03	116	26	2	C0740858
Disease	Schizophrenia	ERVK-8 BLOC1S3 NRXN3 EGR4	7.05e-03	883	26	4	C0036341

Protein segments in the cluster

Peptide	Gene	Start	Entry
RPLERSRKHRPRSRR	CCDC185	91	Q8N715
MQRKAPPRRRRHRNR	ERVK-25	6	P61579
RRLPPTSARHTRRKR	SLC4A3	96	P48751
MQRKAPPRRRRHRNR	ERVK-19	6	O71037
MQRKAPPRRRRHRNR	ERVK-8	6	Q902F8
MQRKAPPRRRRHRNR	ERVK-9	6	Q9UKH3
IPAGRLRRAARPHRR	ANKRD54	86	Q6NXT1
KDIRRCHRMSRRPLP	CBX6	121	O95503
RRARPVRSKARRMAA	BHLHA9	56	Q7RTU4
TLRQRSRRPKMRPAR	C20orf204	141	A0A1B0GTL2
SRRLRRPPHVGRARR	GPR25	226	O00155
MAPRGRRRPRPHRSE	CENPU	1	Q71F23
RRRPRPHRSEGARRS	CENPU	6	Q71F23
MQRKAPPRRRRHRNR	HERVK_113	6	P61574
MQRKAPPRRRRHCNR	HERV-K104	6	P61576
MQRKAPPRRRRHRNR	ERVK-16	6	P61578
MQRKAPPRRRRHRNR	ERVK-19	6	P61572
MQRKAPPRRRRHRNR	ERVK-21	6	P61571
MQRKAPPRRRRHRNR	ERVK-6	6	Q69383
MQRKAPPRRRRHRNR	ERVK-9	6	P61573
MRPRKRQGAVRRRVH	PRKCE	151	Q02156
RHRRRMEEERLRPPS	ENOX2	226	Q16206
LVCSLRRRMRRRPGP	GJD4	216	Q96KN9
ARRHAFFRSPRRMRP	LHX1	246	P48742
ARRHAFFRSPRRMRP	LHX5	246	Q9H2C1
RARPRAPHSRRRAML	EGR4	91	Q05215
MRHSVARPTRLPRRL	DOCK8-AS1	1	Q5T8R8
MQRKAPPRRRRHRNR	ERVK-25	6	P61570
MQRKAPPRRRRHRNR	ERVK-6	6	Q69384
MASQGRRRRPLRRPE	BLOC1S3	1	Q6QNY0
MQRKAPPRRRRHRNR	ERVK-21	6	P61565
MQRKAPPRRRRHRNR	HERVK_113	6	Q902F9
RRLRRHPSRPMRQSR	RSF1	1146	Q96T23
HPSRPMRQSRRLRRK	RSF1	1151	Q96T23
RMVRRRHGPEPERTR	SAMD1	56	Q6SPF0
MPLLRGRCPARRHYR	COX8C	1	Q7Z4L0
RLRRRMDSGRKNRPP	PANK1	221	Q8TE04
PMWRRSPPRMRRRSR	RNPS1	261	Q15287
SPPRMRRRSRSPRRR	RNPS1	266	Q15287
MHLRIHARRSPPRRP	NRXN3	1	Q9HDB5
AMRRHRREPRPPRAF	GDF7	216	Q7Z4P5
RHRGLRPRRQKALRM	GPER1	246	Q99527
AGRRHLPLSRRRREM	ST6GALNAC6	21	Q969X2
HPSRARIRRLSMHPL	PIK3R4	1181	Q99570
MDRRRMALRPGSRRP	PRAC2	1	D3DTV9
RSAARRPRRREAAPR	SRRD	21	Q9UH36
MQRKAPPRRRRHRNR	ERVK-8	6	P61575
RRMHSQPRSRGRPSR	YTHDC1	511	Q96MU7