Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent diacylglycerol kinase activity	DGKD DGKH	2.02e-04	11	39	2	GO:0004143
Domain	SAM	DGKD DGKH EPHA6 EPHA2	3.69e-05	88	40	4	SM00454
Domain	SAM_DOMAIN	DGKD DGKH EPHA6 EPHA2	4.99e-05	95	40	4	PS50105
Domain	SAM	DGKD DGKH EPHA6 EPHA2	5.41e-05	97	40	4	IPR001660
Domain	FN3	FNDC9 OBSL1 IL31RA EPHA6 EPHA2	6.35e-05	199	40	5	PS50853
Domain	-	DGKD DGKH EPHA6 EPHA2	7.65e-05	106	40	4	1.10.150.50
Domain	FN3_dom	FNDC9 OBSL1 IL31RA EPHA6 EPHA2	8.00e-05	209	40	5	IPR003961
Domain	SAM/pointed	DGKD DGKH EPHA6 EPHA2	1.12e-04	117	40	4	IPR013761
Domain	DAGK_acc	DGKD DGKH	1.99e-04	10	40	2	PF00609
Domain	DAGKa	DGKD DGKH	1.99e-04	10	40	2	SM00045
Domain	Diacylglycerol_kin_accessory	DGKD DGKH	1.99e-04	10	40	2	IPR000756
Domain	fn3	OBSL1 IL31RA EPHA6 EPHA2	3.91e-04	162	40	4	PF00041
Domain	RECEPTOR_TYR_KIN_V_2	EPHA6 EPHA2	4.00e-04	14	40	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHA6 EPHA2	4.00e-04	14	40	2	PS00790
Domain	EphA2_TM	EPHA6 EPHA2	4.00e-04	14	40	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHA6 EPHA2	4.00e-04	14	40	2	IPR016257
Domain	Eph_TM	EPHA6 EPHA2	4.00e-04	14	40	2	IPR027936
Domain	Ephrin_rcpt_lig-bd_dom	EPHA6 EPHA2	4.00e-04	14	40	2	IPR001090
Domain	Tyr_kinase_rcpt_V_CS	EPHA6 EPHA2	4.00e-04	14	40	2	IPR001426
Domain	EPH_LBD	EPHA6 EPHA2	4.00e-04	14	40	2	PS51550
Domain	EPH_lbd	EPHA6 EPHA2	4.00e-04	14	40	2	SM00615
Domain	DAGKc	DGKD DGKH	4.00e-04	14	40	2	SM00046
Domain	Ephrin_lbd	EPHA6 EPHA2	4.00e-04	14	40	2	PF01404
Domain	DAGK	DGKD DGKH	4.61e-04	15	40	2	PS50146
Domain	Diacylglycerol_kinase_cat_dom	DGKD DGKH	4.61e-04	15	40	2	IPR001206
Domain	DAGK_cat	DGKD DGKH	4.61e-04	15	40	2	PF00781
Domain	-	CUL9 EPHA6 EPHA2	5.10e-04	73	40	3	2.60.120.260
Domain	NAD/diacylglycerol_kinase	DGKD DGKH	5.96e-04	17	40	2	IPR016064
Domain	FN3	OBSL1 IL31RA EPHA6 EPHA2	6.45e-04	185	40	4	SM00060
Domain	Galactose-bd-like	CUL9 EPHA6 EPHA2	1.07e-03	94	40	3	IPR008979
Domain	Ephrin_rec_like	EPHA6 EPHA2	1.30e-03	25	40	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHA6 EPHA2	1.30e-03	25	40	2	IPR011641
Domain	SAM_2	DGKD DGKH	3.82e-03	43	40	2	PF07647
Domain	zf-C2H2_6	ZNF432 ZNF416 ZNF568 ZNF646	4.45e-03	314	40	4	PF13912
Domain	C1_1	DGKD DGKH	6.63e-03	57	40	2	PF00130
Domain	ZF_DAG_PE_1	DGKD DGKH	8.29e-03	64	40	2	PS00479
Domain	ZF_DAG_PE_2	DGKD DGKH	8.29e-03	64	40	2	PS50081
Domain	C1	DGKD DGKH	8.54e-03	65	40	2	SM00109
Domain	PE/DAG-bd	DGKD DGKH	8.80e-03	66	40	2	IPR002219
Domain	SAM_1	EPHA6 EPHA2	9.32e-03	68	40	2	PF00536
Pubmed	Identification and characterization of two splice variants of human diacylglycerol kinase eta.	DGKD DGKH	1.29e-06	2	40	2	12810723
Pubmed	Glutamatergic GRIN2B and polyaminergic ODC1 genes in suicide attempts: associations and gene-environment interactions with childhood/adolescent physical assault.	GRIN2B ODC1	1.29e-06	2	40	2	22850629
Pubmed	Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method.	DGKD DGKH	3.87e-06	3	40	2	23949095
Pubmed	A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes.	EPHA6 EPHA2	7.73e-06	4	40	2	10607706
Pubmed	Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate.	EPHA6 EPHA2	5.77e-05	10	40	2	25073978
Pubmed	HOXA13 directly regulates EphA6 and EphA7 expression in the genital tubercle vascular endothelia.	EPHA6 EPHA2	5.77e-05	10	40	2	17304517
Pubmed	EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes.	EPHA6 EPHA2	5.77e-05	10	40	2	16547242
Pubmed	Formation of persistent hyperplastic primary vitreous in ephrin-A5-/- mice.	EPHA6 EPHA2	7.05e-05	11	40	2	24550361
Pubmed	Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.	DGKD DGKH	7.05e-05	11	40	2	17021016
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	AACS OBSL1 IFT122 AQR ASB3 RALGAPB	9.31e-05	650	40	6	38777146
Pubmed	EphA family gene expression in the developing mouse neocortex: regional patterns reveal intrinsic programs and extrinsic influence.	EPHA6 EPHA2	9.98e-05	13	40	2	12528186
Pubmed	Eph-ephrin A system regulates murine blastocyst attachment and spreading.	EPHA6 EPHA2	9.98e-05	13	40	2	17039519
Pubmed	Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue.	EPHA6 EPHA2	1.16e-04	14	40	2	26941654
Pubmed	A role for the EphA family in the topographic targeting of vomeronasal axons.	EPHA6 EPHA2	1.16e-04	14	40	2	11222144
Pubmed	Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.	EPHA6 EPHA2	1.53e-04	16	40	2	8755474
Pubmed	Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice.	EPHA6 EPHA2	1.73e-04	17	40	2	12217323
Pubmed	Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.	DGKD DGKH	1.95e-04	18	40	2	24068962
Pubmed	Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases.	ZER1 ASB3	1.95e-04	18	40	2	18187417
Pubmed	Expression of Ephs and ephrins in developing mouse inner ear.	EPHA6 EPHA2	2.18e-04	19	40	2	12684176
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	OBSL1 HSPA12A TMEM201 IFT122 PMPCB EPHA2 AQR RALGAPB	2.48e-04	1487	40	8	33957083
Pubmed	Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.	EPHA6 EPHA2	2.67e-04	21	40	2	9267020
Pubmed	Roles of Eph receptors and ephrins in segmental patterning.	EPHA6 EPHA2	2.67e-04	21	40	2	11128993
Pubmed	Developmental expression of Eph and ephrin family genes in mammalian small intestine.	EPHA6 EPHA2	2.67e-04	21	40	2	20112066
Pubmed	Eph receptors and ephrins demarcate cerebellar lobules before and during their formation.	EPHA6 EPHA2	2.67e-04	21	40	2	10495276
Pubmed	Eph receptors and ephrins: regulators of guidance and assembly.	EPHA6 EPHA2	2.67e-04	21	40	2	10730216
Pubmed	Thalamic afferents influence cortical progenitors via ephrin A5-EphA4 interactions.	EPHA6 EPHA2	3.21e-04	23	40	2	25480914
Pubmed	Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling.	EPHA6 EPHA2	3.21e-04	23	40	2	19542359
Pubmed	Eph receptors and their ephrin ligands are expressed in developing mouse pancreas.	EPHA6 EPHA2	3.50e-04	24	40	2	16446123
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CEP70 OBSL1 CUL9 IFT122 GRIN2B PDE9A ASB3	5.92e-04	1285	40	7	35914814
Pubmed	Analysis of mouse embryonic patterning and morphogenesis by forward genetics.	IFT122 ZNF568	6.66e-04	33	40	2	15755804
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	CEP70 OBSL1 CUL9 DGKH DDX17	7.97e-04	639	40	5	23443559
Pubmed	Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.	EPHA6 EPHA2	1.08e-03	42	40	2	11439183
Interaction	ARHGAP32 interactions	OBSL1 GRIN2B EPHA6 RHOJ EPHA2 ASB3	4.61e-07	149	40	6	int:ARHGAP32
GeneFamily	Sterile alpha motif domain containing	DGKD DGKH EPHA6 EPHA2	1.70e-05	88	32	4	760
GeneFamily	EF-hand domain containing\|Diacylglycerol kinases	DGKD DGKH	1.35e-04	10	32	2	1178
GeneFamily	Fibronectin type III domain containing	FNDC9 IL31RA EPHA6 EPHA2	1.75e-04	160	32	4	555
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHA6 EPHA2	2.73e-04	14	32	2	1095
Computational	Neighborhood of CALM1	ZER1 DDX17 RALGAPB PNMA8A	7.91e-05	110	23	4	GCM_CALM1
Computational	Genes in the cancer module 272.	ALDH4A1 ODC1	2.85e-04	12	23	2	MODULE_272
Computational	Neighborhood of BMPR2	DDX17 RALGAPB PNMA8A	7.54e-04	85	23	3	GCM_BMPR2
Disease	nephrolithiasis	DGKD DGKH	8.31e-04	33	38	2	EFO_0004253
Disease	retinal drusen	AACS LARP1B	1.98e-03	51	38	2	EFO_1001155
Disease	Intellectual Disability	ALDH4A1 GRIN2B ODC1 LMAN2L	2.55e-03	447	38	4	C3714756
Disease	urolithiasis	DGKD DGKH	3.00e-03	63	38	2	MONDO_0024647
Disease	Bipolar Disorder	DGKH GRIN2B LMAN2L PDE9A	3.22e-03	477	38	4	C0005586
Disease	magnesium measurement	LMAN2L DCDC1	3.29e-03	66	38	2	EFO_0004845
Disease	anorexia nervosa	ALDH4A1 ASB3	3.69e-03	70	38	2	MONDO_0005351
Disease	Disproportionate short stature	OBSL1 IFT122	4.45e-03	77	38	2	C0878659
Disease	serum albumin measurement	BCL2L12 LARP1B EPHA2 PAFAH1B2	6.90e-03	592	38	4	EFO_0004535
Disease	urate measurement, bone density	CEP70 DGKD PMPCB ASB3	8.05e-03	619	38	4	EFO_0003923, EFO_0004531

Protein segments in the cluster

Peptide	Gene	Start	Entry
RPGREEILECQVMWE	AACS	6	Q86V21
ETDLHDGWPMICLEK	CCNJ	161	Q5T5M9
GFRPEACWERHMQIE	BCL2L12	16	Q9HB09
MEAIPCVVGDEEVWT	ALDH4A1	61	P30038
LMNTDCVVPDWLHDI	AQR	676	O60306
MLACEVDREDAPVRW	OBSL1	826	O75147
EDWCRGMEVDIHRSL	PNMA8A	11	Q86V59
EAVGWAHPDTICLMV	PMPCB	301	O75439
PIQSWDDIERDMVIC	DCDC1	1716	M0R2J8
IEICGDHGWVDMLID	IFT122	781	Q9HBG6
MTEEEAPCGLELWRV	IL31RA	221	Q8NI17
HMEEANGLVRWPEEA	FNDC9	151	Q8TBE3
EVRPMEVAEPWVDCL	PDE9A	466	O76083
MDIDGKHEWRDCIEV	LMAN2L	226	Q9H0V9
KEPECIHVMRRWEGG	HSPA12A	76	O43301
MWEIVTLECPGHEEV	NBL1	91	P41271
DIIEDEDGVAMPHQW	DGKH	236	Q86XP1
VQEEWVPELKDCMPH	RHOJ	111	Q9H4E5
VDVADNRGWMPIHEA	ASB3	36	Q9Y575
AEDGPRVVFMVDLWH	ASPHD2	336	Q6ICH7
DCGFEHLVPVIEMWA	CEP70	386	Q8NHQ1
EEPRMHCAVDGEWLV	EPHA2	241	P29317
IEDADGIAMPHQWLE	DGKD	226	Q16760
WHMLEILGPEEATED	CUL9	431	Q8IWT3
MCIHGDKSQPERDWV	DDX17	446	Q92841
IVERCDLPEMHVGDW	ODC1	366	P11926
PLECHVGWVMDSRDR	LARP1B	646	Q659C4
IPHAAEDIQGDDRWM	PAFAH1B2	11	P68402
GWDAITEMDEHNRPI	EPHA6	56	Q9UF33
PWEVSLRMENEHVCG	PRSS45P	6	Q7RTY3
VCEPQREEVEERMWA	ZER1	651	Q7Z7L7
EEMFGRHCPEVWEVD	ZNF568	111	Q3ZCX4
HEGERQEPRWEEKGM	ZNF646	316	O15015
DIAQHGLEMVEPWEE	ARHGAP31	896	Q2M1Z3
GLLPEHMAEKLCEAW	TMEM201	276	Q5SNT2
CVWLTEHPDMLDEKD	RALGAPB	841	Q86X10
ALVCWHGMEDEETPE	ZNF416	66	Q9BWM5
PWTMEDERHSRICPE	ZNF432	66	O94892
ELERCRAEGHWDRMP	TTC7A	16	Q9ULT0
WPRMCPETEEQEDDH	GRIN2B	391	Q13224