Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpyruvate dehydrogenase (NAD+) activity

DLAT PDHX

3.11e-046922GO:0034604
GeneOntologyMolecularFunctionpyruvate dehydrogenase [NAD(P)+] activity

DLAT PDHX

3.11e-046922GO:0034603
GeneOntologyMolecularFunctionpyruvate dehydrogenase activity

DLAT PDHX

3.11e-046922GO:0004738
GeneOntologyCellularComponentacetyltransferase complex

OGT ATXN7 DLAT TAF4 TAF9 TRRAP PDHX

5.65e-07109937GO:1902493
GeneOntologyCellularComponenttranscription factor TFTC complex

ATXN7 TAF4 TAF9 TRRAP

1.07e-0618934GO:0033276
GeneOntologyCellularComponentSAGA-type complex

ATXN7 TAF4 TAF9 TRRAP

2.68e-0539934GO:0070461
GeneOntologyCellularComponenthistone acetyltransferase complex

OGT ATXN7 TAF4 TAF9 TRRAP

6.28e-0594935GO:0000123
GeneOntologyCellularComponentalpha-ketoacid dehydrogenase complex

BCKDK DLAT PDHX

6.63e-0518933GO:0045240
GeneOntologyCellularComponentprotein acetyltransferase complex

OGT ATXN7 TAF4 TAF9 TRRAP

1.02e-04104935GO:0031248
GeneOntologyCellularComponentSAGA complex

ATXN7 TAF9 TRRAP

1.83e-0425933GO:0000124
GeneOntologyCellularComponenthistone methyltransferase complex

KMT2C NCOA6 TAF4 TAF9

3.50e-0475934GO:0035097
GeneOntologyCellularComponentpyruvate dehydrogenase complex

DLAT PDHX

5.39e-048932GO:0045254
GeneOntologyCellularComponentRNA polymerase II, holoenzyme

ATXN7 TAF4 TAF9 TRRAP

6.71e-0489934GO:0016591
GeneOntologyCellularComponentcytoplasmic region

RP1L1 GPSM2 TERF2 DNAH7 OPA1 TRAK1 OPRM1

1.13e-03360937GO:0099568
GeneOntologyCellularComponentMLL3/4 complex

KMT2C NCOA6

1.26e-0312932GO:0044666
GeneOntologyCellularComponentmethyltransferase complex

KMT2C NCOA6 TAF4 TAF9

1.38e-03108934GO:0034708
GeneOntologyCellularComponentneuron projection cytoplasm

TERF2 OPA1 TRAK1 OPRM1

1.48e-03110934GO:0120111
GeneOntologyCellularComponentnuclear DNA-directed RNA polymerase complex

ATXN7 TAF4 TAF9 TRRAP

1.63e-03113934GO:0055029
GeneOntologyCellularComponentDNA-directed RNA polymerase complex

ATXN7 TAF4 TAF9 TRRAP

1.80e-03116934GO:0000428
GeneOntologyCellularComponentRNA polymerase complex

ATXN7 TAF4 TAF9 TRRAP

1.97e-03119934GO:0030880
GeneOntologyCellularComponentcentrosome

MKKS SPATC1 RAPGEF6 ALMS1 MCPH1 GPSM2 POC5 NEDD1 FAM110B PDZD2

2.23e-037709310GO:0005813
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

RP1L1 TERF2 DNAH7 OPA1 TRAK1 OPRM1

2.93e-03317936GO:0032838
MousePhenoretina rod cell degeneration

MYO7A RP1L1 MERTK SLC24A1

1.83e-0531724MP:0008451
MousePhenoretina photoreceptor degeneration

ALMS1 MYO7A ATXN7 RP1L1 MERTK SLC24A1

2.23e-05111726MP:0008450
MousePhenoabnormal retina rod cell morphology

MYO7A ATXN7 RP1L1 MERTK SLC24A1

4.96e-0578725MP:0001005
DomainE3_binding

DLAT PDHX

7.02e-053912PF02817
Domain-

DLAT PDHX

7.02e-0539124.10.320.10
DomainE3-bd

DLAT PDHX

7.02e-053912IPR004167
DomainCAT-like_dom

DLAT PDHX

1.40e-044912IPR023213
Domain-

DLAT PDHX

1.40e-0449123.30.559.10
Domain2-oxoacid_dh

DLAT PDHX

1.40e-044912PF00198
Domain2-oxoacid_DH_actylTfrase

DLAT PDHX

1.40e-044912IPR001078
Domain2-oxoA_DH_lipoyl-BS

DLAT PDHX

2.33e-045912IPR003016
DomainLIPOYL

DLAT PDHX

2.33e-045912PS00189
DomainBiotin_lipoyl

DLAT PDHX

8.27e-049912PF00364
DomainBiotin_lipoyl

DLAT PDHX

1.03e-0310912IPR000089
DomainBIOTINYL_LIPOYL

DLAT PDHX

1.03e-0310912PS50968
DomainSingle_hybrid_motif

DLAT PDHX

1.50e-0312912IPR011053
DomainSEA

MUC17 MUC16

2.06e-0314912SM00200
Domain-

MKKS CCT7

2.06e-03149121.10.560.10
DomainGROEL-like_equatorial

MKKS CCT7

2.06e-0314912IPR027413
DomainCpn60/TCP-1

MKKS CCT7

2.37e-0315912IPR002423
DomainCpn60_TCP1

MKKS CCT7

2.37e-0315912PF00118
Domain-

MKKS CCT7

2.37e-03159123.50.7.10
Domain-

MUC17 MUC16

2.37e-03159123.30.70.960
DomainGroEL-like_apical_dom

MKKS CCT7

2.37e-0315912IPR027409
DomainVWD

MUC5B VWDE

2.70e-0316912SM00216
DomainVWF_type-D

MUC5B VWDE

2.70e-0316912IPR001846
DomainVWFD

MUC5B VWDE

2.70e-0316912PS51233
DomainAT_hook

KMT2C SETBP1

2.70e-0316912PF02178
DomainVWD

MUC5B VWDE

2.70e-0316912PF00094
DomainDS_RBD

DICER1 SON

4.64e-0321912PS50137
PathwayREACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC

MUC17 MUC16 MUC5B

5.75e-0516683M27410
PathwayREACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS

MUC17 MUC16 MUC5B

6.96e-0517683M27412
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC17 MUC16 MUC5B

1.34e-0421683MM15706
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC17 MUC16 MUC5B

1.77e-0423683M556
PathwayREACTOME_DECTIN_2_FAMILY

MUC17 MUC16 MUC5B

2.58e-0426683M27483
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS19 MUC17 MUC16 MUC5B

3.20e-0468684M27303
PathwayREACTOME_PDH_COMPLEX_SYNTHESIZES_ACETYL_COA_FROM_PYR

DLAT PDHX

3.40e-046682M48273
PathwayREACTOME_PDH_COMPLEX_SYNTHESIZES_ACETYL_COA_FROM_PYR

DLAT PDHX

3.40e-046682MM17245
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR10G9 OR4D2 OR10G7 OR10G4

3.57e-0470684MM14984
PathwayWP_16P112_PROXIMAL_DELETION_SYNDROME

BPTF KMT2C SPN CCT7

4.89e-0476684M40057
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ZNF512B BPTF OGT EIF4ENIF1 ALMS1 ATXN7 RTL9 CIZ1 DLAT TAF4 TAF9 TRRAP DICER1 OPA1 PDZRN3 PDHX SON

7.40e-091116941731753913
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

ZCCHC14 KMT2C NCOA6 ALMS1 RHOBTB2 SETBP1 CHD6 WNK1 DICER1

1.12e-0822594912168954
Pubmed

Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

BPTF ATXN7 CHD6 TAF4 TAF9 TRRAP EMSY

4.89e-0812494720850016
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ZNF512B BPTF KMT2C NCOA6 ZBTB39 OGT MCPH1 CIZ1 CHD6 TAF4 TAF9 TERF2 TRRAP MNT SF1 EMSY SON

6.36e-081294941730804502
Pubmed

UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation.

ATXN7 TAF4 TAF9 TRRAP

2.35e-072094411406595
Pubmed

Function of TAF(II)-containing complex without TBP in transcription by RNA polymerase II.

ATXN7 TAF4 TAF9 TRRAP

2.35e-07209449603525
Pubmed

Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.

ATXN7 TAF4 TAF9 TRRAP

2.35e-072094410373431
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

BPTF KMT2C NCOA6 UBA1 ZBTB39 OGT AP1B1 CCT7 TAF4 TAF9 NEDD1 TRRAP MNT SF1 EMSY

2.69e-071103941534189442
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

BPTF KMT2C NCOA6 UBA1 RAPGEF6 OGT ALMS1 CIZ1 TAF4 TRRAP EMSY

2.91e-07549941138280479
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

BPTF KMT2C OGT TAF4 TAF9 TRRAP EMSY

3.74e-0716794720362541
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

EIF4ENIF1 ALMS1 MAVS BCKDK CCT7 POC5 PPIP5K2 NEDD1 DNAH7 PDZRN3 PDHX EMSY FAM110B

5.13e-07853941328718761
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

ZCCHC14 EIF4ENIF1 ALMS1 MAVS CHD6 POC5 PPIP5K2 NEDD1 WNK1 DICER1 PDZRN3 TNS3

6.92e-07733941234672954
Pubmed

C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.

IPO5 OGT AP1B1 DLAT CCT7 TAF4

9.00e-0711994635776542
Pubmed

Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.

BPTF KMT2C NCOA6 OGT CCT7 TERF2

9.00e-0711994623508102
Pubmed

PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.

NCOA6 OGT TRRAP EMSY NPM2

9.41e-076594522496869
Pubmed

The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.

ATXN7 TAF4 TAF9 TRRAP

9.75e-072894419114550
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

BPTF NCOA6 UBA1 RAPGEF6 ATXN7 IQCN TERF2 TRRAP CTTNBP2NL SF1 EMSY SON

1.22e-06774941215302935
Pubmed

A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.

ATXN7 TAF4 TAF9 TRRAP

1.30e-063094418206972
Pubmed

Human transcription factor protein interaction networks.

ZNF512B BPTF KMT2C NCOA6 OGT EIF4ENIF1 ALMS1 ATXN7 DLAT CCT7 CHD6 TAF4 TAF9 TRRAP MNT EMSY

1.35e-061429941635140242
Pubmed

Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear.

ALMS1 MYO7A GPSM2

1.59e-06994328346477
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

RAPGEF6 EIF4ENIF1 ALMS1 DICER1 CTTNBP2NL TNS3 TRAK1

1.68e-0620994736779422
Pubmed

Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.

ATXN7 TAF4 TAF9 TRRAP

1.93e-063394411564863
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

KMT2C OGT EIF4ENIF1 ATXN7 BCKDK CIZ1 CCT7 CHD6 TAF4 TAF9 TERF2 TRRAP DICER1 CTTNBP2NL EMSY SON

2.47e-061497941631527615
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

UBA1 MAVS ATXN7 TAF4 TAF9 NEDD1 CTTNBP2NL SF1 EMSY

3.39e-0644494934795231
Pubmed

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.

MKKS ALMS1 ATXN7 RP1L1 MERTK SLC24A1 DICER1

3.45e-0623394732290105
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

ZCCHC14 NCOA6 RAPGEF6 ALMS1 PLEKHA3 PPIP5K2 WNK1 PRAG1 DNAH7 TNS3 TRAK1 FAM110B

3.65e-06861941236931259
Pubmed

Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.

MKKS ALMS1 MYO7A MERTK CA4

4.02e-068794520801516
Pubmed

Interaction network of human early embryonic transcription factors.

ZNF512B BPTF KMT2C NCOA6 OGT ALMS1 TAF4 EMSY

5.20e-0635194838297188
Pubmed

Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration.

ATXN7 TAF9 TRRAP

5.36e-061394315932940
Pubmed

ATAC and SAGA co-activator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct.

ATXN7 TAF4 TAF9 TRRAP

6.25e-064494437682711
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

UBA1 RAPGEF6 MYO7A CIZ1 IQCN NEDD1

6.66e-0616894630631154
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

ZNF512B BPTF DUSP18 OGT MAP6 BCKDK CHD6 PPIP5K2 TAF9 TRRAP OPA1 SF1 SON

6.97e-061082941338697112
Pubmed

Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly.

MCPH1 TERF2

7.23e-06294233203878
Pubmed

Roles of the tetratricopeptide repeat domain in O-GlcNAc transferase targeting and protein substrate specificity.

OGT TRAK1

7.23e-06294212724313
Pubmed

MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity.

KMT2C TNS3

7.23e-06294233824309
Pubmed

Tonicity-responsive microRNAs contribute to the maximal induction of osmoregulatory transcription factor OREBP in response to high-NaCl hypertonicity.

NFAT5 DICER1

7.23e-06294220852262
Pubmed

Abnormal nociception and opiate sensitivity of STOP null mice exhibiting elevated levels of the endogenous alkaloid morphine.

MAP6 OPRM1

7.23e-06294221172011
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

ZNF512B UBA1 RAPGEF6 ALMS1 MAVS CIZ1 CCT7 NEDD1 WNK1 SF1 EMSY SON

8.31e-06934941233916271
Pubmed

Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis.

TAF4 TAF9 TRRAP

8.50e-061594312601814
Pubmed

Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.

IPO5 KMT2C NCOA6 OGT

8.89e-064894427703004
Pubmed

Histone-like TAFs within the PCAF histone acetylase complex.

TAF4 TAF9 TRRAP

1.26e-05179439674425
Pubmed

Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.

MUC17 MUC16 MUC5B

1.51e-051894318834073
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ZCCHC14 RHOBTB2 CHD6 NFAT5 OPA1 TRAK1 SON PDZD2

1.52e-0540794812693553
Pubmed

Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module.

ATXN7 TAF9 TRRAP

2.11e-052094327601583
Pubmed

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.

KMT2C NCOA6 OGT

2.11e-052094329785026
Pubmed

Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase.

DLAT PDHX

2.16e-05394212816949
Pubmed

Alström Syndrome protein ALMS1 localizes to basal bodies of cochlear hair cells and regulates cilium-dependent planar cell polarity.

MKKS ALMS1

2.16e-05394221071598
Pubmed

Targeted disruption of the murine dihydrolipoamide dehydrogenase gene (Dld) results in perigastrulation lethality.

DLAT PDHX

2.16e-0539429405644
Pubmed

DUSP28 links regulation of Mucin 5B and Mucin 16 to migration and survival of AsPC-1 human pancreatic cancer cells.

MUC16 MUC5B

2.16e-05394227230679
Pubmed

Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity.

DLAT PDHX

2.16e-05394225525879
Pubmed

Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors.

KMT2C NCOA6

2.16e-05394218372346
Pubmed

Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis.

KMT2C NCOA6

2.16e-05394221330447
Pubmed

Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex.

DLAT PDHX

2.16e-0539429242632
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

NCOA6 EIF4ENIF1 MAVS EMSY PDZD2

2.18e-0512394526912792
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ZNF512B IPO5 BPTF OGT CIZ1 CHD6 TAF4 TRRAP EMSY

4.09e-0560894936089195
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

IPO5 BPTF KMT2C ALMS1 RTL9 CHD6 TERF2 TRRAP

4.16e-0546994827634302
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

IPO5 UBA1 AP1B1 CCT7 WNK1 TRRAP SON

4.27e-0534494730333137
Pubmed

Oxidative metabolism of pyruvate is required for meiotic maturation of murine oocytes in vivo.

DLAT PDHX

4.32e-05494217314311
Pubmed

Whole-exome sequencing identifies ALMS1, IQCB1, CNGA3, and MYO7A mutations in patients with Leber congenital amaurosis.

ALMS1 MYO7A

4.32e-05494221901789
Pubmed

Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase.

OGT TRAK1

4.32e-05494224995978
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

BPTF KMT2C TAF9 TRRAP EMSY

4.95e-0514694523892456
Pubmed

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.

BPTF TRRAP EMSY

5.34e-052794323395962
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

IPO5 KMT2C UBA1 OGT PLEKHA3 DLAT TAF4 NEDD1 WNK1 TRRAP DICER1 MNT EMSY

5.85e-051327941332694731
Pubmed

Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders.

ZBTB39 NFAT5 EMSY

5.96e-052894329365100
Pubmed

A High-Density Map for Navigating the Human Polycomb Complexome.

ZNF512B BPTF KMT2C NCOA6 OGT CCT7 MNT TRAK1

6.07e-0549594827705803
Pubmed

Subunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complex.

DLAT PDHX

7.19e-05594219240034
Pubmed

Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

ATXN7 TRRAP

7.19e-05594216494529
Pubmed

Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components.

DLAT PDHX

7.19e-05594214638692
Pubmed

Dead Cells Induce Innate Anergy via Mertk after Acute Viral Infection.

MAVS MERTK

7.19e-05594232187540
Pubmed

Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase.

OGT TRAK1

7.19e-05594212435728
Pubmed

E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis.

DLAT PDHX

7.19e-05594227621431
Pubmed

Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.

AP1B1 MAP6 OPA1

9.84e-053394326025364
Pubmed

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

NCOA6 MUC16 MUC5B DNAH7 OPRM1

1.02e-0417094523314748
Pubmed

Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.

MUC16 MUC5B

1.08e-04694219110483
Pubmed

TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs.

MCPH1 TERF2

1.08e-04694219287395
Pubmed

Component co-expression and purification of recombinant human pyruvate dehydrogenase complex from baculovirus infected SF9 cells.

DLAT PDHX

1.08e-04694224534072
Pubmed

Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes.

ATXN7 TRRAP

1.08e-04694215115762
Pubmed

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

KMT2C NCOA6

1.08e-04694217021013
Pubmed

Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus.

IPO5 SLC24A1 SF1

1.08e-043494325505242
Pubmed

A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs.

TAF9 TRRAP MNT

1.18e-043594320946988
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

IPO5 OGT DLAT TERF2 TRRAP OPA1 SON

1.28e-0441094726949251
Pubmed

The functional interactome landscape of the human histone deacetylase family.

ZNF512B IPO5 CCT7 DICER1 EMSY SON

1.38e-0428994623752268
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

BPTF DUSP18 MUC16 CHD6 ARMCX5 DNAH7 TNS3

1.48e-0442094728065597
Pubmed

The role of sensory organs and the forebrain for the development of the craniofacial shape as revealed by Foxg1-cre-mediated microRNA loss.

MYO7A DICER1

1.50e-04794221225654
Pubmed

Primary Pyruvate Dehydrogenase Complex Deficiency Overview

DLAT PDHX

1.50e-04794234138529
Pubmed

A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4.

KMT2C NCOA6

1.50e-04794219433796
Pubmed

Induced alpha-helix structure in the aryl hydrocarbon receptor transactivation domain modulates protein-protein interactions.

TAF4 TAF9

1.50e-04794215641800
Pubmed

ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.

KMT2C NCOA6

1.50e-04794219556342
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

NCOA6 RAPGEF6 EIF4ENIF1 SETBP1 WNK1 FAM110B SON

1.71e-0443094735044719
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

BPTF KMT2C OGT MCPH1 ATXN7 SETBP1 CHD6 IQCN TAF4 NEDD1 NFAT5 TRRAP PDZD2

1.84e-041489941328611215
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ZBTB39 ALMS1 WNK1 PDZD2

1.87e-041049449205841
Pubmed

MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51.

UBA1 MAVS OPA1

1.89e-044194334964862
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

ZNF512B IPO5 EIF4ENIF1 ALMS1 MAVS BCKDK DLAT CCT7 OPA1 SF1 PDHX TRAK1 SON

1.93e-041496941332877691
Pubmed

Core promoter binding by histone-like TAF complexes.

TAF4 TAF9

2.00e-04894215601843
Pubmed

Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.

BPTF KMT2C

2.00e-04894221447625
Pubmed

Rack1 regulates cellular patterning and polarity in the mouse cochlea.

MYO7A GPSM2

2.00e-04894236252648
Pubmed

AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.

IPO5 UBA1 CIZ1 CCT7 OPA1

2.17e-0420094535546148
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

UBA1 OGT EIF4ENIF1 MYO7A RTL9 CIZ1 PPIP5K2 NEDD1 WNK1 DICER1 OPA1 FAM110B

2.32e-041321941227173435
Pubmed

WT1-mediated gene regulation in early urogenital ridge development.

MKKS MUC16 CA4

2.50e-044594318391535
Pubmed

The Krüppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathway.

GPSM2 WNK1

2.57e-04994217289029
Cytoband11q13.5

MAP6 MYO7A EMSY

1.08e-052194311q13.5
GeneFamilyCD molecules|Mucins

MUC17 MUC16 MUC5B

4.89e-0521623648
GeneFamilyChaperonins

MKKS CCT7

1.18e-0315622587
GeneFamilyOlfactory receptors, family 10

OR10G9 OR10G7 OR10G4

1.51e-0366623157
GeneFamilyLysine acetyltransferases|ATAC complex|SAGA complex|GCN5 related N-acetyltransferases

ATXN7 TRRAP

1.52e-03176221059
GeneFamilyZinc fingers CCHC-type|RNA binding motif containing

ZCCHC14 SF1

3.30e-032562274
CoexpressionNAGY_TFTC_COMPONENTS_HUMAN

ATXN7 TAF4 TAF9 TRRAP

4.19e-0718924M2974
CoexpressionNAGY_STAGA_COMPONENTS_HUMAN

ATXN7 TAF9 TRRAP

1.17e-0513923M10514
CoexpressionNIKOLSKY_MUTATED_AND_AMPLIFIED_IN_BREAST_CANCER

ZCCHC14 NCOA6 AHRR MYO7A OR4D2

2.05e-0594925M18108
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

ZCCHC14 NCOA6 MXRA5 COL12A1 CHD6 TNS3

2.95e-0618894614bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

ADAMTS19 BPTF CHD6 WNK1 NFAT5 PRAG1

3.33e-06192946916fbec1c7ab7969bda711886ac88e877e30c280
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

ADAMTS19 BPTF CHD6 WNK1 NFAT5 PRAG1

3.43e-06193946e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS19 COL12A1 KLF18 MUC5B CACNA2D3

2.27e-05160945c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS19 COL12A1 KLF18 MUC5B CACNA2D3

2.27e-0516094525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|367C / Donor, Lineage, Cell class and subclass (all cells)

NCOA6 DUSP18 EIF4ENIF1 MCPH1 TERF2

2.34e-05161945f470b662566131dfe69a2fd01186ac8491196396
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRRC53 MUC16 MUC5B DNAH7 MAP3K19

3.58e-05176945dee780cfa85234a7cd7bf440b66b84cec959893e
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

NCOA6 COL12A1 CHD6 TAF4 TNS3

3.78e-05178945edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

IQCN PRAG1 TFAP2B CACNA2D3 CA4

4.20e-05182945a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCellcontrol-immature_Neutrophil|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZNF512B ZCCHC14 VWDE TNS3 CACNA2D3

5.03e-05189945bdfd120900ba58d5e54765f7b576e1f8cc2401bf
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

NCOA6 DUSP18 EIF4ENIF1 MCPH1 TERF2

5.16e-051909452434b8ad2976eab7d9147012c28454ab29670709
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

NCOA6 DUSP18 EIF4ENIF1 MCPH1 TERF2

5.29e-0519194539ef8e1d7cc3ebb11717e8a55501515e3b72b177
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

KMT2C RAPGEF6 OGT ATXN7 SF1

5.42e-0519294547646d7e4990be85072987f92bf18d52f8da752e
ToppCellMonocytes-NUPR1+_Monocytes|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

NPL AP1B1 MERTK SLC15A3 TNS3

5.83e-051959455e12201ce7ba912e7faa123ca200e609252ba288
ToppCellMonocytes|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

NPL AP1B1 MERTK SLC15A3 TNS3

5.98e-05196945ab0a8f5f388c9794d7f41f99fb0a5f2fd6fff6b3
ToppCellCOVID-19-lung-Macrophage_metabolically_active|lung / Disease (COVID-19 only), tissue and cell type

NPL AP1B1 MYO7A MERTK TNS3

5.98e-05196945a753d76d764c181eecb0e17a794a2e7d0ff70136
ToppCell(2)_Fibroblasts-(24)_Fibro-5|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis

DUSP18 COL12A1 BPIFC MAP6 WNK1

6.12e-0519794583a4b79fbfa1cf63441dee4424c3b87c988287bf
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NPL AP1B1 MYO7A MERTK TNS3

6.27e-05198945c7dbf24caae5c4ef285845d13055de9e07281bb3
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAP6 MUC16 DNAH7 TRAK1 MAP3K19

6.27e-05198945d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCellwk_20-22-Hematologic-Myeloid-SPP1+_Mac|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

NPL AP1B1 MYO7A MERTK SLC15A3

6.42e-051999457c19f1b1f4369edd035ca9cdcf4e653771fc4648
ToppCellwk_15-18-Hematologic-Myeloid-SPP1+_Mac|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

NPL AP1B1 MYO7A MERTK SLC15A3

6.42e-05199945c7fc2ac1601346aac71e7620a8a440fde8d92dbd
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

BPTF KMT2C COL12A1 MFSD4A SON

6.58e-05200945dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BPTF KMT2C DDX60L SF1 SON

6.58e-0520094512f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NPL AP1B1 MYO7A MERTK TNS3

6.58e-0520094578d75d381cb2b9a4c9eb7c32a07b014eaee39195
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

BPTF MXRA5 COL12A1 OGT NFAT5

6.19e-0650575GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_4
DiseaseDisorder of eye

MKKS ALMS1 MYO7A MERTK SLC24A1 OPA1 CA4

4.04e-06212907C0015397
DiseaseIntellectual Disability

BPTF KMT2C AP1B1 RHOBTB2 BCKDK SETBP1 TRRAP PDHX

6.83e-05447908C3714756
DiseasePyruvate dehydrogenase complex deficiency

DLAT PDHX

9.15e-055902cv:C0034345
Diseasepyruvate decarboxylase deficiency (is_implicated_in)

DLAT PDHX

1.37e-046902DOID:3649 (is_implicated_in)
DiseaseLeigh syndrome

DLAT PDHX

2.55e-048902cv:C0023264
Diseaseserum alanine aminotransferase measurement

BPTF COL12A1 RAPGEF6 RHOBTB2 PLEKHA3 RP1L1 NKX2-3 IQCN MERTK PRAG1

3.18e-048699010EFO_0004735
DiseaseN-acetylleucine measurement

ALMS1 CCT7

3.27e-049902EFO_0800116
Diseasemetabolic syndrome

BPTF RTL9 POC5 NFAT5 TFAP2B

3.75e-04200905EFO_0000195
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

BPTF SETBP1 POC5 IQCN NFAT5 TFAP2B

8.82e-04364906EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Diseasecholangiocarcinoma (is_marker_for)

MUC16 MFSD4A MUC5B

9.99e-0464903DOID:4947 (is_marker_for)
DiseaseHereditary hearing loss and deafness

MYO7A DLAT GPSM2 PDHX

1.06e-03146904cv:C0236038
Diseasecongenital heart disease (implicated_via_orthology)

KMT2C CHD6 SON

1.24e-0369903DOID:1682 (implicated_via_orthology)
DiseaseDystonia, Paroxysmal

CIZ1 DLAT

1.36e-0318902C0393588
DiseaseSchizophrenia

IPO5 RAPGEF6 MAP6 HTR3D TRRAP DICER1 OPA1 TRAK1 OPRM1

1.50e-03883909C0036341
Diseasewaist circumference

BPTF BCKDK SETBP1 POC5 NFAT5 TFAP2B

2.03e-03429906EFO_0004342
Diseaseasthma

RAPGEF6 ZBTB39 MAVS MUC16 PMEL PRAG1 EMSY OPRM1

2.10e-03751908MONDO_0004979
DiseaseEtat Marbre

ATXN7 OPRM1

2.23e-0323902C0266487
Diseaseresponse to radiation, Hematuria

ATXN7 CACNA2D3

2.23e-0323902GO_0009314, HP_0000790
DiseaseDystonia

CIZ1 DLAT PDHX

2.34e-0386903C0013421
Diseaseresponse to venlafaxine

COL12A1 MCPH1

2.64e-0325902EFO_0006328
DiseaseNeurodevelopmental Disorders

KMT2C SETBP1 CACNA2D3

2.92e-0393903C1535926

Protein segments in the cluster

PeptideGeneStartEntry
MVPGMLPKSALATLV

AHRR

676

A9YTQ3
VSKGTATEPLMLMSV

CTTNBP2NL

296

Q9P2B4
MTISLGKTPRTMEVT

ADGRG4

1261

Q8IZF6
GKTPRTMEVTEMSPS

ADGRG4

1266

Q8IZF6
QMPSPEPMKKFTTSI

ALMS1

2701

Q8TCU4
PLSTVGSVMKMEPLN

AP1B1

796

Q10567
PVMAVMPGTTDTIQV

DICER1

1256

Q9UPY3
AAAEKPSVRLTPTMM

BCKDK

61

O14874
MVAPISGSVTTGTKM

BPTF

2076

Q12830
SIVPQTKSKAMPMSR

ARMCX5

101

Q6P1M9
VPVPPKSVTSLMMNK

TFAP2B

201

Q92481
TPKVVTTMATMPTAT

MUC5B

4876

Q9HC84
HIMALTKMSSPSPPV

PDZRN3

366

Q9UPQ7
SVMVPSKLPGMTYTA

ADAMTS19

551

Q8TE59
TVTKTAPHTCPMPTM

IQCN

386

Q9H0B3
SPGSPEMSTTLKIMS

MUC16

3196

Q8WXI7
AEMMIKTQTDPPGST

MUC16

8196

Q8WXI7
RISSSLAIMGVSPPM

POC5

501

Q8NA72
LAIMGVSPPMSSVVV

POC5

506

Q8NA72
PMDKLVSIGHTVMTP

OR4D2

266

P58180
VPKMLMTLVSPSGRT

OR10G7

76

Q8NGN6
PTGSPSMITAITIMA

OPRM1

61

P35372
VPKMLMTLVSPSGRA

OR10G4

76

Q8NGN3
TTSIIPKMLGTMLTS

OR13G1

71

Q8NGZ3
MEPLTKMTGTQPIGS

MKKS

321

Q9NPJ1
TPPKMMLKTSSVPVV

GPSM2

526

P81274
IMPTTYISVTPKIGM

KMT2C

811

Q8NEZ4
AGMVPSKVPTSMVLT

MAVS

356

Q7Z434
PMVSASVKDQGPMVS

MAP6

586

Q96JE9
PTRTLVMTSMPSEKQ

MCPH1

646

Q8NEM0
TVLPQPMTSAMGKGT

NEDD1

351

Q8NHV4
IPSMPKRTAKMIPTT

SLC24A1

111

O60721
SIPISSRMKPATMVF

MFSD4A

366

Q8N468
CIEMSSQGIPKPMVI

MERTK

656

Q12866
PQVSSVKLSTMMSPT

SPN

221

P16150
VEINRSMMSPKISTP

LRRC53

646

A6NM62
EKMPSVGFIPMTSAV

DDX60L

436

Q5H9U9
VLLPALSPTMTMGTV

DLAT

221

P10515
MPSLSPTMEEGNIVK

PDHX

61

O00330
LPQMAKSPSIMTLTI

PDZD2

2411

O15018
VTMVTMPSFPVSTLK

MNT

566

Q99583
VMGPLMKTASIKPEV

IPO5

626

O00410
ALMTPLIPSSMIKSE

NFAT5

591

O94916
LIPSSMIKSEDVTPM

NFAT5

596

O94916
TGSPAESIKRMSVMV

ATXN7

781

O15265
STVVTMPNAGSKVMV

NCOA6

1626

Q14686
MMTRSPVKVTLSEGP

OPA1

321

O60313
PASIMMLTQPKNSTV

BPIFC

361

Q8NFQ6
ALSNIPKPEMSTTMA

CA4

186

P22748
TSSEPISIMEKTQPM

COL12A1

411

Q99715
QGPVLMTTVAMPVFS

CACNA2D3

471

Q8IZS8
PTGEEVKSTLSMLPM

CHD6

2506

Q8TD26
SMKSPPAGVKLVMEA

DNAH7

2696

Q8WXX0
MPTETLQTGSMVKPV

FAM110B

1

Q8TC76
ESTQSKTMPPLGSTM

KLF18

51

A0A0U1RQI7
ITVPVSGSPKMSNIM

EMSY

231

Q7Z589
FITKPPMGSQVSSML

SLC15A3

251

Q8IY34
MMLPSPVTSTPFSVK

NKX2-3

1

Q8TAU0
SVLPMVSMVGVQLSP

NPM2

86

Q86SE8
TVFEMATGKPPLASM

MAP3K19

1256

Q56UN5
VPKMLMTLVSPSGRA

OR10G9

76

Q8NGN4
TPMVTMPGETLASRV

OGT

941

O15294
GNTPLTRMPVSTTMV

MUC17

2336

Q685J3
TKAIMTLVSGIPMGP

NPL

266

Q9BXD5
VPASGAMTTSLMTVP

RTL9

431

Q8NET4
KPLMTPKASGTMFTE

RTL9

616

Q8NET4
QVKAPISGAMSMPLT

RTL9

836

Q8NET4
PASTAASMVIGPTMQ

TAF4

366

O00268
TPQTMSVSTKVGTPM

TAF9

166

Q16594
MSPVPMRSAGQTTKA

RAPGEF6

1156

Q8TEU7
ATPVFMPVGTQATMK

QTRT1

41

Q9BXR0
AVLPSPRKSMVASVM

OR7E24

281

Q6IFN5
LMVVVKMDSSIQPGP

RHOBTB2

411

Q9BYZ6
MMPTPVILLKEGTDS

CCT7

1

Q99832
VGMSESPIGPKSTML

TNS3

896

Q68CZ2
STGMTPEKVPVSEVM

PMEL

371

P40967
MLSPSFTPTSVIRKM

EIF4ENIF1

691

Q9NRA8
TPAGLMASMSIVKAT

HTR3D

131

Q70Z44
MEKTLPEPVGTQVSM

CIZ1

501

Q9ULV3
PTMVGSSMQMKAPVT

TRAK1

921

Q9UPV9
SSMQMKAPVTLTSGI

TRAK1

926

Q9UPV9
LPGKSMSDTLPVSMT

VWDE

601

Q8N2E2
KVSPMSPKATMGATR

RP1L1

1666

Q8IWN7
AMSQSSPLIAPVMGT

SPATC1

176

Q76KD6
KPTIAVKPTMMSSEA

PRAG1

81

Q86YV5
PLSAMVSMVTKDNPG

UBA1

216

P22314
SPVSPSPVQMMKRSV

PLEKHA3

196

Q9HB20
IPSMMTQPLLGTVST

ZBTB39

221

O15060
TVSRPMPVTKAMPVT

ZNF512B

241

Q96KM6
MPVTKAMPVTKPITV

ZNF512B

246

Q96KM6
TKVAFSAMSSMPVGP

ZCCHC14

681

Q8WYQ9
DIPIVPTTSGTMMEL

PPIP5K2

366

O43314
PEMITVTSAVGPVSM

WNK1

1806

Q9H4A3
PTMMTRKKPAAVDSV

SETBP1

1356

Q9Y6X0
PPEMVGMITTIAVKV

TRRAP

186

Q9Y4A5
TMEQKTVIPGMPTVI

SF1

26

Q15637
SEQSVAVMPEPSMTK

SON

226

P18583
PPTTIGMMTLKAAFK

TERF2

321

Q15554
PVSRMASIPSMIGEK

ELFN2

466

Q5R3F8
KNTVHMVSSPVGMIP

DUSP18

161

Q8NEJ0
PDSTLGIMSSMSPVK

MXRA5

1096

Q9NR99
GIMSSMSPVKKPAET

MXRA5

1101

Q9NR99
KPIMLPVTFMDGTTK

MYO7A

1256

Q13402