Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	2.11e-11	37	63	7	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	2.58e-11	38	63	7	GO:0070001
GeneOntologyMolecularFunction	endopeptidase activity	MBTPS1 ERVK-8 PCSK7 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 PCSK4	8.91e-07	430	63	10	GO:0004175
GeneOntologyMolecularFunction	xenobiotic transmembrane transporter activity	ABCC1 SLC37A3 SLC47A1 ABCG2	3.89e-06	34	63	4	GO:0042910
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-8 ERVK-7 ERVK-10	4.85e-06	11	63	3	GO:0004523
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-8 ERVK-7 ERVK-10 DBR1	5.49e-06	37	63	4	GO:0016891
GeneOntologyMolecularFunction	peptidase activity	MBTPS1 ERVK-8 PCSK7 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 PCSK4 AGTPBP1	5.59e-06	654	63	11	GO:0008233
GeneOntologyMolecularFunction	sulfate adenylyltransferase (ATP) activity	PAPSS2 PAPSS1	9.80e-06	2	63	2	GO:0004781
GeneOntologyMolecularFunction	sulfate adenylyltransferase activity	PAPSS2 PAPSS1	9.80e-06	2	63	2	GO:0004779
GeneOntologyMolecularFunction	adenylylsulfate kinase activity	PAPSS2 PAPSS1	9.80e-06	2	63	2	GO:0004020
GeneOntologyMolecularFunction	CTP synthase activity	CTPS2 CTPS1	9.80e-06	2	63	2	GO:0003883
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-8 ERVK-7 ERVK-10	1.06e-05	14	63	3	GO:0003964
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-8 ERVK-7 ERVK-10 DBR1	1.33e-05	46	63	4	GO:0016893
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-8 ERVK-7 ERVK-10	3.82e-05	21	63	3	GO:0035613
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-8 ERVK-7 ERVK-10 DBR1	1.13e-04	79	63	4	GO:0004521
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-8 ERVK-7 ERVK-10 PAPSS2 PAPSS1	1.18e-04	152	63	5	GO:0016779
GeneOntologyMolecularFunction	vitamin transmembrane transporter activity	ABCC1 SLC47A1 ABCG2	1.98e-04	36	63	3	GO:0090482
GeneOntologyMolecularFunction	vascular endothelial growth factor receptor activity	PDGFRA NRP2	2.04e-04	7	63	2	GO:0005021
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-8 ERVK-7 ERVK-10	2.33e-04	38	63	3	GO:0034061
GeneOntologyMolecularFunction	amide transmembrane transporter activity	ABCC1 SLC47A1 ABCG2	3.15e-04	42	63	3	GO:0042887
GeneOntologyMolecularFunction	structural molecule activity	RPL22 COL9A1 ERVK-8 SNTG1 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	4.43e-04	891	63	10	GO:0005198
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCC1 ABCC12 ABCG2	4.97e-04	49	63	3	GO:0140359
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-8 ERVK-7 ERVK-10 DBR1	8.98e-04	136	63	4	GO:0004540
GeneOntologyMolecularFunction	endonuclease activity	ERVK-8 ERVK-7 ERVK-10 DBR1	8.98e-04	136	63	4	GO:0004519
GeneOntologyMolecularFunction	sulfur compound transmembrane transporter activity	ABCC1 SLC47A1 ABCG2	9.45e-04	61	63	3	GO:1901682
GeneOntologyMolecularFunction	ABC-type xenobiotic transporter activity	ABCC1 ABCG2	1.00e-03	15	63	2	GO:0008559
GeneOntologyMolecularFunction	efflux transmembrane transporter activity	ABCC1 ABCG2	1.14e-03	16	63	2	GO:0015562
GeneOntologyMolecularFunction	sphingolipid transporter activity	ABCC1 ABCG2	1.79e-03	20	63	2	GO:0046624
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	PDGFRA GNE MYLK4 ERVK-8 ERVK-7 ERVK-10 PAPSS2 PAPSS1 NRP2	2.59e-03	938	63	9	GO:0016772
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC12A6 ABCC1 SLC37A3 SLC47A1 ABCC12 ABCG2	3.87e-03	477	63	6	GO:0022804
GeneOntologyMolecularFunction	adenylyltransferase activity	PAPSS2 PAPSS1	4.29e-03	31	63	2	GO:0070566
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCC1 ABCC12 ABCG2	4.95e-03	109	63	3	GO:0042626
GeneOntologyMolecularFunction	nuclease activity	ERVK-8 ERVK-7 ERVK-10 DBR1	6.10e-03	231	63	4	GO:0004518
GeneOntologyMolecularFunction	zinc ion binding	ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 AGTPBP1	6.72e-03	891	63	8	GO:0008270
GeneOntologyBiologicalProcess	DNA integration	ERVK-8 ERVK-7 ERVK-10	7.24e-06	13	62	3	GO:0015074
GeneOntologyBiologicalProcess	purine ribonucleoside bisphosphate biosynthetic process	PAPSS2 PAPSS1	8.89e-06	2	62	2	GO:0034036
GeneOntologyBiologicalProcess	'de novo' CTP biosynthetic process	CTPS2 CTPS1	8.89e-06	2	62	2	GO:0044210
GeneOntologyBiologicalProcess	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	PAPSS2 PAPSS1	8.89e-06	2	62	2	GO:0050428
GeneOntologyBiologicalProcess	xenobiotic transport	ABCC1 SLC37A3 SLC47A1 ABCG2	4.11e-05	64	62	4	GO:0042908
GeneOntologyBiologicalProcess	sulfate assimilation	PAPSS2 PAPSS1	5.31e-05	4	62	2	GO:0000103
GeneOntologyBiologicalProcess	xenobiotic detoxification by transmembrane export across the plasma membrane	ABCC1 SLC47A1 ABCG2	7.19e-05	27	62	3	GO:1990961
GeneOntologyBiologicalProcess	viral process	KIAA0319L ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	7.20e-05	464	62	8	GO:0016032
GeneOntologyBiologicalProcess	protein retention in Golgi apparatus	VPS13C VPS13A	8.84e-05	5	62	2	GO:0045053
GeneOntologyBiologicalProcess	xenobiotic export from cell	ABCC1 SLC47A1 ABCG2	8.94e-05	29	62	3	GO:0046618
GeneOntologyBiologicalProcess	cell-cell fusion	ERVK-8 ERVK-19 ERVK-21 ERVK-9	1.25e-04	85	62	4	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	ERVK-8 ERVK-19 ERVK-21 ERVK-9	1.25e-04	85	62	4	GO:0000768
GeneOntologyBiologicalProcess	xenobiotic transport across blood-brain barrier	ABCC1 ABCG2	1.32e-04	6	62	2	GO:1990962
GeneOntologyBiologicalProcess	syncytium formation	ERVK-8 ERVK-19 ERVK-21 ERVK-9	1.49e-04	89	62	4	GO:0006949
GeneOntologyBiologicalProcess	pyrimidine nucleobase biosynthetic process	CTPS2 CTPS1	2.46e-04	8	62	2	GO:0019856
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-8 ERVK-7 ERVK-10	4.06e-04	48	62	3	GO:0000731
GeneOntologyCellularComponent	cytoophidium	CTPS2 CTPS1	2.68e-05	3	63	2	GO:0097268
GeneOntologyCellularComponent	endoplasmic reticulum membrane	MBTPS1 EMC7 PLOD3 FMO5 MOGAT1 SLC37A3 PDGFRA VPS13C TMEM132A VPS13A KCNK2 ABCC12	4.20e-04	1293	63	12	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	MBTPS1 EMC7 PLOD3 FMO5 MOGAT1 SLC37A3 PDGFRA VPS13C TMEM132A VPS13A KCNK2 ABCC12	4.38e-04	1299	63	12	GO:0098827
GeneOntologyCellularComponent	endoplasmic reticulum lumen	MBTPS1 COL9A1 PLOD3 TMEM132A PCSK7 PCSK4	4.87e-04	332	63	6	GO:0005788
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	MBTPS1 EMC7 PLOD3 FMO5 MOGAT1 SLC37A3 PDGFRA VPS13C TMEM132A VPS13A KCNK2 ABCC12	5.31e-04	1327	63	12	GO:0042175
GeneOntologyCellularComponent	apical plasma membrane	SLC12A6 ABCC1 FAT1 KCNK2 MPDZ SLC47A1 ABCG2	6.40e-04	487	63	7	GO:0016324
Domain	Peptidase_S8_His-AS	MBTPS1 PCSK7 PCSK4	2.36e-06	9	58	3	IPR022398
Domain	Peptidase_S8_Ser-AS	MBTPS1 PCSK7 PCSK4	2.36e-06	9	58	3	IPR023828
Domain	Peptidase_S8_subtilisin-rel	MBTPS1 PCSK7 PCSK4	3.36e-06	10	58	3	IPR015500
Domain	SUBTILASE_ASP	MBTPS1 PCSK7 PCSK4	3.36e-06	10	58	3	PS00136
Domain	SUBTILASE_HIS	MBTPS1 PCSK7 PCSK4	3.36e-06	10	58	3	PS00137
Domain	SUBTILASE_SER	MBTPS1 PCSK7 PCSK4	3.36e-06	10	58	3	PS00138
Domain	Peptidase_S8	MBTPS1 PCSK7 PCSK4	4.61e-06	11	58	3	PF00082
Domain	-	MBTPS1 PCSK7 PCSK4	4.61e-06	11	58	3	3.40.50.200
Domain	Peptidase_S8/S53_dom	MBTPS1 PCSK7 PCSK4	4.61e-06	11	58	3	IPR000209
Domain	CTP_synthase_N	CTPS2 CTPS1	9.48e-06	2	58	2	IPR017456
Domain	GATase1_CTP_Synthase	CTPS2 CTPS1	9.48e-06	2	58	2	IPR033828
Domain	APS_kinase	PAPSS2 PAPSS1	9.48e-06	2	58	2	IPR002891
Domain	Sulphate_adenylyltransferase	PAPSS2 PAPSS1	9.48e-06	2	58	2	IPR002650
Domain	ATP-Sase_PUA-like_dom	PAPSS2 PAPSS1	9.48e-06	2	58	2	IPR025980
Domain	PUA_2	PAPSS2 PAPSS1	9.48e-06	2	58	2	PF14306
Domain	CTP_synthase	CTPS2 CTPS1	9.48e-06	2	58	2	IPR004468
Domain	Sulfurylase_cat_dom	PAPSS2 PAPSS1	9.48e-06	2	58	2	IPR024951
Domain	CTP_synth_N	CTPS2 CTPS1	9.48e-06	2	58	2	PF06418
Domain	ATP-sulfurylase	PAPSS2 PAPSS1	9.48e-06	2	58	2	PF01747
Domain	-	ABCC1 RRAS2 CTPS2 RAB4B ABCC12 ABCG2 RRAS CTPS1 NUBPL PAPSS2 PAPSS1	1.57e-05	746	58	11	3.40.50.300
Domain	VPS13_N2	VPS13C VPS13A	2.84e-05	3	58	2	IPR031646
Domain	VPS13_mid_rpt	VPS13C VPS13A	2.84e-05	3	58	2	IPR031642
Domain	VPS13	VPS13C VPS13A	2.84e-05	3	58	2	IPR026847
Domain	VPS13_mid_rpt	VPS13C VPS13A	2.84e-05	3	58	2	PF16910
Domain	VPS13	VPS13C VPS13A	2.84e-05	3	58	2	PF16908
Domain	P-loop_NTPase	ABCC1 RRAS2 CTPS2 RAB4B ABCC12 ABCG2 RRAS CTPS1 NUBPL PAPSS2 PAPSS1	5.10e-05	848	58	11	IPR027417
Domain	VPS13_C	VPS13C VPS13A	5.66e-05	4	58	2	IPR031645
Domain	VPS13_C	VPS13C VPS13A	5.66e-05	4	58	2	PF16909
Domain	SHR-BD	VPS13C VPS13A	5.66e-05	4	58	2	PF06650
Domain	SHR-BD	VPS13C VPS13A	5.66e-05	4	58	2	IPR009543
Domain	ATG_C	VPS13C VPS13A	9.42e-05	5	58	2	PF09333
Domain	GATase	CTPS2 CTPS1	9.42e-05	5	58	2	PF00117
Domain	Autophagy-rel_C	VPS13C VPS13A	9.42e-05	5	58	2	IPR015412
Domain	GATASE	CTPS2 CTPS1	1.41e-04	6	58	2	IPR017926
Domain	GATASE_TYPE_1	CTPS2 CTPS1	1.41e-04	6	58	2	PS51273
Domain	PrprotnconvertsP	PCSK7 PCSK4	1.97e-04	7	58	2	IPR002884
Domain	P_proprotein	PCSK7 PCSK4	1.97e-04	7	58	2	PF01483
Domain	S8_pro-domain	PCSK7 PCSK4	1.97e-04	7	58	2	IPR032815
Domain	-	PCSK7 PCSK4	1.97e-04	7	58	2	3.30.70.850
Domain	S8_pro-domain	PCSK7 PCSK4	1.97e-04	7	58	2	PF16470
Domain	VPS13_N	VPS13C VPS13A	2.62e-04	8	58	2	IPR026854
Domain	Chorein_N	VPS13C VPS13A	2.62e-04	8	58	2	PF12624
Domain	-	CTPS2 CTPS1	4.20e-04	10	58	2	3.40.50.880
Domain	ABC_TRANSPORTER_2	ABCC1 ABCC12 ABCG2	4.45e-04	48	58	3	PS50893
Domain	ABC_tran	ABCC1 ABCC12 ABCG2	4.45e-04	48	58	3	PF00005
Domain	ABC_TRANSPORTER_1	ABCC1 ABCC12 ABCG2	4.73e-04	49	58	3	PS00211
Domain	ABC_transporter-like	ABCC1 ABCC12 ABCG2	5.02e-04	50	58	3	IPR003439
Domain	Class_I_gatase-like	CTPS2 CTPS1	6.13e-04	12	58	2	IPR029062
Domain	Propept_inh	PCSK7 PCSK4	1.25e-03	17	58	2	IPR009020
Domain	-	PCSK7 PCSK4 NRP2	1.52e-03	73	58	3	2.60.120.260
Domain	PUA-like_domain	PAPSS2 PAPSS1	1.57e-03	19	58	2	IPR015947
Domain	-	FMO5 NMRAL1 HSD17B14 DCXR	1.88e-03	169	58	4	3.40.50.720
Domain	NAD(P)-bd_dom	FMO5 NMRAL1 HSD17B14 DCXR	2.04e-03	173	58	4	IPR016040
Domain	ABC_membrane	ABCC1 ABCC12	2.50e-03	24	58	2	PF00664
Domain	Galactose-bd-like	PCSK7 PCSK4 NRP2	3.12e-03	94	58	3	IPR008979
Domain	ABC_TM1F	ABCC1 ABCC12	3.40e-03	28	58	2	PS50929
Domain	ABC1_TM_dom	ABCC1 ABCC12	3.40e-03	28	58	2	IPR011527
Domain	RAS	RRAS2 RRAS	5.28e-03	35	58	2	PS51421
Domain	Sc_DH/Rdtase_CS	HSD17B14 DCXR	5.28e-03	35	58	2	IPR020904
Domain	Small_GTPase_Ras	RRAS2 RRAS	5.89e-03	37	58	2	IPR020849
Domain	ABC_transporter_CS	ABCC1 ABCC12	7.54e-03	42	58	2	IPR017871
Domain	Rossmann-like_a/b/a_fold	PAPSS2 PAPSS1	7.89e-03	43	58	2	IPR014729
Pathway	REACTOME_TRANSPORT_AND_SYNTHESIS_OF_PAPS	PAPSS2 PAPSS1	1.17e-04	6	40	2	M27027
Pathway	REACTOME_TRANSPORT_AND_SYNTHESIS_OF_PAPS	PAPSS2 PAPSS1	1.17e-04	6	40	2	MM14679
Pathway	REACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES	ABCC1 ABCG2	2.17e-04	8	40	2	M48022
Pathway	KEGG_ABC_TRANSPORTERS	ABCC1 ABCC12 ABCG2	2.59e-04	44	40	3	M11911
Pathway	WP_IRINOTECAN_PATHWAY	ABCC1 ABCG2	5.09e-04	12	40	2	M39611
Pathway	REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES	RPL22 NMRAL1 BCKDHB MCCC2 PAPSS2 PAPSS1	5.35e-04	366	40	6	M727
Pathway	KEGG_SULFUR_METABOLISM	PAPSS2 PAPSS1	6.00e-04	13	40	2	M18256
Pathway	REACTOME_HEME_DEGRADATION	ABCC1 ABCG2	8.05e-04	15	40	2	M27060
Pathway	WP_SULFATION_BIOTRANSFORMATION_REACTION	PAPSS2 PAPSS1	1.04e-03	17	40	2	M39483
Pathway	WP_INHIBITION_OF_EXOSOME_BIOGENESIS_AND_SECRETION_BY_MANUMYCIN_A_IN_CRPC_CELLS	RRAS2 RRAS	1.17e-03	18	40	2	M39737
Pathway	REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM	BCKDHB MCCC2	1.44e-03	20	40	2	MM15397
Pathway	WP_IMATINIB_AND_CHRONIC_MYELOID_LEUKEMIA	PDGFRA ABCG2	1.44e-03	20	40	2	M39381
Pathway	REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM	BCKDHB MCCC2	1.59e-03	21	40	2	M17694
Pathway	WP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE	RRAS2 PDGFRA RRAS	1.72e-03	84	40	3	M39839
Pathway	REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES	PAPSS2 PAPSS1	1.91e-03	23	40	2	MM14597
Pathway	REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES	PAPSS2 PAPSS1	2.08e-03	24	40	2	M16289
Pathway	WP_LEUCINE_ISOLEUCINE_AND_VALINE_METABOLISM	BCKDHB MCCC2	2.08e-03	24	40	2	M45511
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	5.14e-10	94	65	7	21542922
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-8 ERVK-19 ERVK-21 ERVK-9	5.44e-09	12	65	4	14557543
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-7 ERVK-10 ERVK-24	2.49e-08	4	65	3	10469592
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-21 ERVK-9 ERVK-10 ERVK-24	3.33e-08	18	65	4	18664271
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-19 ERVK-7 ERVK-21	6.21e-08	5	65	3	12629516
Pubmed	The activation and physiological functions of the proprotein convertases.	MBTPS1 PCSK7 PCSK4	5.19e-07	9	65	3	18343183
Pubmed	The prohormone theory and the proprotein convertases: it is all about serendipity.	MBTPS1 PCSK7 PCSK4	5.19e-07	9	65	3	21805236
Pubmed	The proprotein convertases, 20 years later.	MBTPS1 PCSK7 PCSK4	5.19e-07	9	65	3	21805237
Pubmed	The biology and therapeutic targeting of the proprotein convertases.	MBTPS1 PCSK7 PCSK4	5.19e-07	9	65	3	22679642
Pubmed	The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.	MBTPS1 PCSK7 PCSK4	5.19e-07	9	65	3	23775089
Pubmed	A member of a family of sulfate-activating enzymes causes murine brachymorphism.	PAPSS2 PAPSS1	3.44e-06	2	65	2	9671738
Pubmed	The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters.	ABCC1 ABCG2	3.44e-06	2	65	2	27033456
Pubmed	R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System.	RRAS2 RRAS	3.44e-06	2	65	2	35055164
Pubmed	Brain-specific transcript variants of 5' and 3' ends of mouse VPS13A and VPS13C.	VPS13C VPS13A	3.44e-06	2	65	2	17196930
Pubmed	Absence of R-Ras1 and R-Ras2 causes mitochondrial alterations that trigger axonal degeneration in a hypomyelinating disease model.	RRAS2 RRAS	3.44e-06	2	65	2	33010069
Pubmed	Nuclear localization of PAPS synthetase 1: a sulfate activation pathway in the nucleus of eukaryotic cells.	PAPSS2 PAPSS1	3.44e-06	2	65	2	10657990
Pubmed	Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization.	PAPSS2 PAPSS1	3.44e-06	2	65	2	10679223
Pubmed	R-Ras is required for murine dendritic cell maturation and CD4+ T-cell priming.	RRAS2 RRAS	3.44e-06	2	65	2	22174156
Pubmed	Variants in FAT1 and COL9A1 genes in male population with or without substance use to assess the risk factors for oral malignancy.	COL9A1 FAT1	3.44e-06	2	65	2	30657779
Pubmed	Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse.	PAPSS2 PAPSS1	3.44e-06	2	65	2	9771708
Pubmed	Characterization and expression of human bifunctional 3'-phosphoadenosine 5'-phosphosulphate synthase isoforms.	PAPSS2 PAPSS1	3.44e-06	2	65	2	11931637
Pubmed	Expression of MRP1 and ABCG2 is associated with adverse clinical outcomes of papillary thyroid carcinoma with a solid component.	ABCC1 ABCG2	3.44e-06	2	65	2	28411177
Pubmed	Genetic variation in efflux transporters influences outcome to methotrexate therapy in patients with psoriasis.	ABCC1 ABCG2	3.44e-06	2	65	2	18256692
Pubmed	mRNA expression profile of multidrug resistance genes in childhood acute lymphoblastic leukemia. Low expression levels associated with a higher risk of toxic death.	ABCC1 ABCG2	3.44e-06	2	65	2	19672972
Pubmed	Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasm.	PAPSS2 PAPSS1	3.44e-06	2	65	2	22242175
Pubmed	Regulation of human cytidine triphosphate synthetase 2 by phosphorylation.	CTPS2 CTPS1	3.44e-06	2	65	2	20739275
Pubmed	Friend or foe: ABCG2, ABCC1 and ABCB1 expression in triple-negative breast cancer.	ABCC1 ABCG2	1.03e-05	3	65	2	33420675
Pubmed	VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites.	VPS13C VPS13A	1.03e-05	3	65	2	30093493
Pubmed	Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A.	CTPS2 CTPS1	1.03e-05	3	65	2	16179339
Pubmed	R-Ras controls axon branching through afadin in cortical neurons.	RRAS2 RRAS	1.03e-05	3	65	2	22593211
Pubmed	ATP-binding cassette proteins BCRP, MRP1 and P-gp expression and localization in the human umbilical cord.	ABCC1 ABCG2	1.03e-05	3	65	2	26407213
Pubmed	Imaging of activity of multidrug resistance-associated protein 1 in the lungs.	ABCC1 ABCG2	1.03e-05	3	65	2	23596979
Pubmed	Role of ABC-cassette transporters (MDR1, MRP1, BCRP) in the development of primary and acquired multiple drug resistance in patients with early and metastatic breast cancer.	ABCC1 ABCG2	1.03e-05	3	65	2	24382439
Pubmed	Efflux excretion of bisdemethoxycurcumin-O-glucuronide in UGT1A1-overexpressing HeLa cells: Identification of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins 1 (MRP1) as the glucuronide transporters.	ABCC1 ABCG2	1.03e-05	3	65	2	30334318
Pubmed	Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3.	RRAS2 RRAS	1.03e-05	3	65	2	10777492
Pubmed	ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice.	ABCC1 ABCG2	1.03e-05	3	65	2	22545122
Pubmed	A new fluorescent dye accumulation assay for parallel measurements of the ABCG2, ABCB1 and ABCC1 multidrug transporter functions.	ABCC1 ABCG2	1.03e-05	3	65	2	29342177
Pubmed	H-Ras, R-Ras, and TC21 differentially regulate ureteric bud cell branching morphogenesis.	RRAS2 RRAS	1.03e-05	3	65	2	16467383
Pubmed	Polymorphisms in xenobiotic transporters ABCB1, ABCG2, ABCC2, ABCC1, ABCC3 and multiple myeloma risk: a case-control study in the context of the International Multiple Myeloma rESEarch (IMMEnSE) consortium.	ABCC1 ABCG2	1.03e-05	3	65	2	22182917
Pubmed	Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells.	RRAS2 RRAS	1.03e-05	3	65	2	14724565
Pubmed	Multidrug resistance proteins in gastrointestinal stromal tumors: site-dependent expression and initial response to imatinib.	ABCC1 ABCG2	1.03e-05	3	65	2	16278376
Pubmed	Changes in dipole membrane potential at the mouse blood-brain barrier enhance the transport of 99mTechnetium Sestamibi more than inhibiting Abcb1, Abcc1, or Abcg2.	ABCC1 ABCG2	1.03e-05	3	65	2	19067785
Pubmed	TBC1D1 interacting proteins, VPS13A and VPS13C, regulate GLUT4 homeostasis in C2C12 myotubes.	VPS13C VPS13A	1.03e-05	3	65	2	33087848
Pubmed	[Correlation of chemosensitivity measured by histoculture drug response assay to expression of multidrug resistance genes and proteins in gastric cancer].	ABCC1 ABCG2	1.03e-05	3	65	2	19622290
Pubmed	Expression and promoter methylation analysis of ATP-binding cassette genes in pancreatic cancer.	ABCC1 ABCG2	1.03e-05	3	65	2	21956451
Pubmed	Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin.	ABCC1 ABCG2	1.03e-05	3	65	2	16960658
Pubmed	Promoter methylation patterns of ABCB1, ABCC1 and ABCG2 in human cancer cell lines, multidrug-resistant cell models and tumor, tumor-adjacent and tumor-distant tissues from breast cancer patients.	ABCC1 ABCG2	1.03e-05	3	65	2	27689338
Pubmed	Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24).	ABCC1 ABCG2	1.03e-05	3	65	2	17445775
Pubmed	ABC transporter (P-gp/ABCB1, MRP1/ABCC1, BCRP/ABCG2) expression in the developing human CNS.	ABCC1 ABCG2	1.03e-05	3	65	2	19165709
Pubmed	Mechanism of the efflux transport of demethoxycurcumin-O-glucuronides in HeLa cells stably transfected with UDP-glucuronosyltransferase 1A1.	ABCC1 ABCG2	1.03e-05	3	65	2	31150474
Pubmed	Expression and function of ABC-transporter protein ABCB1 correlates with inhibitory capacity of Ruxolitinib in vitro and in vivo.	ABCC1 ABCG2	1.03e-05	3	65	2	26589910
Pubmed	Relationships between multidrug resistance (MDR) and stem cell markers in human chronic myeloid leukemia cell lines.	ABCC1 ABCG2	2.06e-05	4	65	2	19969351
Pubmed	[Role of PTEN protein in multidrug resistance of prostate cancer cells].	ABCC1 ABCG2	2.06e-05	4	65	2	18702307
Pubmed	Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia.	ABCC1 ABCG2	2.06e-05	4	65	2	18200595
Pubmed	Analysis of the human VPS13 gene family.	VPS13C VPS13A	2.06e-05	4	65	2	15498460
Pubmed	Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice.	ABCC1 ABCG2	2.06e-05	4	65	2	21881209
Pubmed	FLT3-ITD and MLL-PTD influence the expression of MDR-1, MRP-1, and BCRP mRNA but not LRP mRNA assessed with RQ-PCR method in adult acute myeloid leukemia.	ABCC1 ABCG2	2.06e-05	4	65	2	24030729
Pubmed	R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.	RRAS2 RRAS	2.06e-05	4	65	2	34530870
Pubmed	Positive correlation between cyclooxygenase-2 and ABC-transporter expression in non-Hodgkin's lymphomas.	ABCC1 ABCG2	2.06e-05	4	65	2	19885582
Pubmed	R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes.	RRAS2 RRAS	2.06e-05	4	65	2	29844052
Pubmed	cGMP transport by vesicles from human and mouse erythrocytes.	ABCC1 ABCG2	2.06e-05	4	65	2	17229149
Pubmed	Genetic variations in ABC transporter genes as a predictive biomarker for toxicity in North Indian lung cancer patients undergoing platinum-based doublet chemotherapy.	ABCC1 ABCG2	2.06e-05	4	65	2	36507589
Pubmed	The Tcf21 lineage constitutes the lung lipofibroblast population.	RPL22 PDGFRA	2.06e-05	4	65	2	30675802
Pubmed	R-Ras1 and R-Ras2 Are Essential for Oligodendrocyte Differentiation and Survival for Correct Myelination in the Central Nervous System.	RRAS2 RRAS	2.06e-05	4	65	2	29720552
Pubmed	Expression of multidrug resistance 1 (MDR1), multidrug resistance-related protein 1 (MRP1), lung resistance protein (LRP), and breast cancer resistance protein (BCRP) genes and clinical outcome in childhood acute lymphoblastic leukemia.	ABCC1 ABCG2	2.06e-05	4	65	2	17875533
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-19 ERVK-10	2.06e-05	4	65	2	7983737
Pubmed	Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo.	ABCC1 ABCG2	2.06e-05	4	65	2	16041239
Pubmed	Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier.	ABCC1 ABCG2	2.06e-05	4	65	2	26507673
Pubmed	Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML).	ABCC1 ABCG2	2.06e-05	4	65	2	11986944
Pubmed	RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response.	ABCC1 ABCG2	3.43e-05	5	65	2	12576456
Pubmed	Pharmacogenetics of telatinib, a VEGFR-2 and VEGFR-3 tyrosine kinase inhibitor, used in patients with solid tumors.	ABCC1 ABCG2	3.43e-05	5	65	2	19924384
Pubmed	Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily.	RRAS2 RRAS	3.43e-05	5	65	2	10224125
Pubmed	Expression profile of Papss2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) during cartilage formation and skeletal development in the mouse embryo.	PAPSS2 PAPSS1	3.43e-05	5	65	2	17436279
Pubmed	Characterization of R-ras3/m-ras null mice reveals a potential role in trophic factor signaling.	RRAS2 RRAS	5.13e-05	6	65	2	16980617
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-19 ERVK-9	5.13e-05	6	65	2	15063128
Pubmed	Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice.	CTPS2 CTPS1	5.13e-05	6	65	2	38438357
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	SLC12A6 ABCC1 RRAS2 MBTPS1 FAT1 EMC7 KIAA0319L PRXL2A TMEM263	6.72e-05	952	65	9	38569033
Pubmed	Proteolytic processing in the secretory pathway.	PCSK7 PCSK4	7.18e-05	7	65	2	10409610
Pubmed	The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.	PCSK7 PCSK4	7.18e-05	7	65	2	7819324
Pubmed	Association of multi-drug resistance gene polymorphisms with pancreatic cancer outcome.	ABCC1 ABCG2	7.18e-05	7	65	2	20922799
Pubmed	Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.	PCSK7 PCSK4	9.56e-05	8	65	2	9885250
Pubmed	Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.	ABCC1 ABCC12	9.56e-05	8	65	2	15802388
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	LSR FAT1 VPS13C KIAA0319L VPS13A IFFO2 MCCC2 TMEM263	9.83e-05	777	65	8	35844135
Pubmed	Diverse Targets of β-Catenin during the Epithelial-Mesenchymal Transition Define Cancer Stem Cells and Predict Disease Relapse.	ABCC1 ABCC12	1.23e-04	9	65	2	26122848
Pubmed	The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1.	RRAS2 RRAS	1.23e-04	9	65	2	11857081
Pubmed	SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.	PCSK7 PCSK4	1.23e-04	9	65	2	8698813
Pubmed	CTPS and IMPDH form cytoophidia in developmental thymocytes.	CTPS2 CTPS1	1.53e-04	10	65	2	34022203
Pubmed	Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.	PCSK7 PCSK4	1.53e-04	10	65	2	16163737
Pubmed	Irinotecan pathway genotype analysis to predict pharmacokinetics.	ABCC1 ABCG2	1.53e-04	10	65	2	12960109
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-19 ERVK-21	1.53e-04	10	65	2	12970426
Pubmed	Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation.	ABCC1 ABCG2	1.87e-04	11	65	2	18619525
Pubmed	Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization.	RRAS2 RRAS	1.87e-04	11	65	2	15031288
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FAT1 PLOD3 SLC37A3 TULP4 SZT2 TMEM132A KIAA0319L NUBPL EML3	2.07e-04	1105	65	9	35748872
Pubmed	Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.	ABCC1 ABCG2	2.24e-04	12	65	2	19349540
Pubmed	Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741.	ABCC1 ABCG2	2.65e-04	13	65	2	20530282
Pubmed	Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells.	RPL22 PDGFRA	3.08e-04	14	65	2	27516371
Pubmed	Astrocyte-intrinsic and -extrinsic Fat1 activities regulate astrocyte development and angiogenesis in the retina.	FAT1 PDGFRA	3.08e-04	14	65	2	35050341
Pubmed	Conservation of notochord gene expression across chordates: insights from the Leprecan gene family.	PAPSS2 PAPSS1	3.08e-04	14	65	2	18798549
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	RPL22 ABCC1 RRAS2 FAT1 EMC7 PLOD3 PDGFRA MCCC2 CTPS1 NRP2	3.42e-04	1451	65	10	30550785
Pubmed	The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.	NMRAL1 HSD17B14 DCXR	3.53e-04	73	65	3	19027726
Interaction	ST8SIA4 interactions	FAT1 PDGFRA TMEM132A KIAA0319L NRP2	5.52e-06	84	61	5	int:ST8SIA4
Interaction	CEACAM8 interactions	MBTPS1 FAT1 TMEM132A BCKDHB NRP2	3.01e-05	119	61	5	int:CEACAM8
Interaction	NAAA interactions	MBTPS1 CTPS2 TMEM132A NUBPL TMEM263 NRP2	5.32e-05	220	61	6	int:NAAA
Interaction	BRINP3 interactions	FAT1 PDGFRA NRP2	5.79e-05	25	61	3	int:BRINP3
GeneFamily	Proprotein convertase subtilisin/kexin family	MBTPS1 PCSK7 PCSK4	4.20e-07	9	32	3	973
GeneFamily	ATP binding cassette subfamily C	ABCC1 ABCC12	2.34e-04	13	32	2	807
GeneFamily	Short chain dehydrogenase/reductase superfamily	NMRAL1 HSD17B14 DCXR	3.24e-04	76	32	3	743
GeneFamily	RAS type GTPase family	RRAS2 RRAS	1.37e-03	31	32	2	389
GeneFamily	PDZ domain containing	SNTG1 MPDZ PRX	2.42e-03	152	32	3	1220
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LSR PRXL2A LHFPL6 ABCG2 PAPSS2 PRX	2.39e-07	200	58	6	c239e6f5d23caa9a59b83e9b352b2d6a691dcb28
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO5 MOGAT1 SLC47A1 ABCG2 PAPSS2	2.52e-06	166	58	5	8ab18c9d911eb3a9970bba7a769294b0927538f7
ToppCell	Severe-Myeloid-Macrophages-FABP4+\|Severe / Condition, Lineage, Cell class and cell subclass	SLC47A1 ABCG2 HSD17B14 DCXR NRP2	5.12e-06	192	58	5	30aad927ad40d8abaf9d0539bf8cb9d88d16f24d
ToppCell	medial-2-Endothelial-Capillary_Aerocyte\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LSR LHFPL6 RRAS PAPSS2 PRX	6.10e-06	199	58	5	c5048b31649a0b7eddcd481b0458ed96508f5561
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LSR PRXL2A ABCG2 PAPSS2 PRX	6.10e-06	199	58	5	c5c12c8288fe868322bae9d691b91fee953ceb3e
ToppCell	medial-Endothelial-Capillary_Aerocyte\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LSR LHFPL6 RRAS PAPSS2 PRX	6.10e-06	199	58	5	84e30c39c2f050aa64af167999824c1cba32ba05
ToppCell	medial-Endothelial-Capillary_Aerocyte-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LSR LHFPL6 RRAS PAPSS2 PRX	6.10e-06	199	58	5	f1039d1ab498fc58f0feba545df05833c235db74
ToppCell	NS-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FAT1 CTPS2 LHFPL6 SLC47A1	5.63e-05	160	58	4	8a4746463ca1976f7d6de803496c851249ced797
ToppCell	TCGA-Mesothelium-Primary_Tumor-Mesothelioma-Epitheliod-1\|TCGA-Mesothelium / Sample_Type by Project: Shred V9	NMRAL1 KLHL35 RRAS PCSK4	5.77e-05	161	58	4	9e03aa7c50b4e8cf1f726a524b5b03af886535b1
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL35 LHFPL6 ABCC12 HSD17B14	6.34e-05	165	58	4	6d315e0734079ad05336cc2c3f24d870c9105bc8
ToppCell	facs-Kidney-nan-24m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO5 MOGAT1 PRXL2A SLC47A1	6.34e-05	165	58	4	02a09d0918b103aca21c36b42c5a8a8ebad8686c
ToppCell	facs-Kidney-nan-24m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO5 MOGAT1 PRXL2A SLC47A1	6.34e-05	165	58	4	906321cb5f299d77436fb5540fd8c52d7532beca
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL35 LHFPL6 ABCC12 HSD17B14	6.34e-05	165	58	4	84f5597b1bb75f42de9a224196bb8ac198bbe3bf
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MOGAT1 SLC47A1 ABCG2 DCXR	6.49e-05	166	58	4	0868f45d8d39ad39b5cee5e81ac3dd4dc512775d
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-2_VIP_RPL41P3\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL9A1 KCNK2 SLC47A1 NRP2	6.80e-05	168	58	4	0a7f81266576409560396356d16989e944865844
ToppCell	droplet-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MOGAT1 SLC47A1 ABCG2 PAPSS2	6.80e-05	168	58	4	dd48da83c32d41a62f80cd7e5e5c64e42776fa27
ToppCell	facs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO5 MOGAT1 ABCG2 PAPSS2	6.96e-05	169	58	4	922086f218135b734b7d370b871923e50141edce
ToppCell	facs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO5 MOGAT1 ABCG2 PAPSS2	6.96e-05	169	58	4	ee27bcfe3f9a295ec5fb0a375d77d1050e5cbaad
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_4\|390C / Donor, Lineage, Cell class and subclass (all cells)	MOGAT1 EFCAB13 KLHL35 NRP2	7.12e-05	170	58	4	439167e44a1bd5ac8e1e457351dd202ec968db46
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-2_VIP_RPL41P3\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL9A1 KCNK2 SLC47A1 NRP2	7.12e-05	170	58	4	31e3f57673c99f4d8ef30faa9c40e5f7f5bf6460
ToppCell	pdx-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	FMO5 CTPS2 EFCAB13 KIAA0319L	8.14e-05	176	58	4	1e21f80cf0e695ffdd63e4a72cf1e3fa41b60341
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC12A6 FMO5 MOGAT1 SLC47A1	8.32e-05	177	58	4	2f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_proximal_straight_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC47A1 ABCG2 PAPSS2 DCXR	8.88e-05	180	58	4	b34d933cdabf692f02eaaf65c2aaca1fb9510627
ToppCell	facs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC47A1 ABCG2 PAPSS2 DCXR	9.07e-05	181	58	4	bec7076efe94898213a62db72d171d737949977e
ToppCell	facs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC47A1 ABCG2 PAPSS2 DCXR	9.07e-05	181	58	4	cf149b30b814cf87c9e923ef502cadf7fe4a3597
ToppCell	(00)_Basal-(0)_uninjured\|(00)_Basal / shred by cell type and Timepoint	FAT1 SLC47A1 RRAS PAPSS2	9.27e-05	182	58	4	c02c9cab4389d80f318f4bb8d703c1e719672624
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC47A1 ABCG2 PAPSS2 DCXR	9.27e-05	182	58	4	be8dd52898525ce6632af0adc2801944f3ac10bd
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC47A1 ABCG2 PAPSS2 DCXR	9.27e-05	182	58	4	faf0dfa3adc2d2706b6942b5127093ccdc856447
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PALM3 SLC47A1 ABCG2 DCXR	9.47e-05	183	58	4	92f54c267135cb5edbcacd26a0f29e62469bb7e5
ToppCell	Basal\|World / shred by cell class for mouse tongue	PLOD3 TMEM132A PRXL2A RRAS	9.47e-05	183	58	4	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PALM3 SLC47A1 ABCG2 DCXR	9.47e-05	183	58	4	5c4f7d02ba3a3c4a22ac71302e7c9a47e205eef5
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC47A1 ABCG2 PAPSS2 DCXR	9.67e-05	184	58	4	c86ed59fed687cdaaf7e9c4418d2e3e2c4111cca
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC47A1 ABCG2 PAPSS2 DCXR	9.67e-05	184	58	4	45577ff91c3b2b303acd97239dde2463ea7a429c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC12A6 FMO5 MOGAT1 SLC47A1	9.67e-05	184	58	4	9434731f651820b05335085582960f08fbf895de
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5+_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LSR VPS13C PALM3 HSD17B14	9.67e-05	184	58	4	e7b9c69fc77040c5191ad8089697051e2589c30e
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC47A1 ABCG2 PAPSS2 DCXR	9.67e-05	184	58	4	7c256bcfa07c5ff55aad0833e8712b0456b5832b
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC47A1 ABCG2 PAPSS2 DCXR	9.67e-05	184	58	4	3d7dd193a0826cc7a4e454a29236a16c315e5965
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC47A1 ABCG2 PAPSS2 DCXR	9.87e-05	185	58	4	3e3217c99719fd1d2fa94e16be7712a7e5077152
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC47A1 ABCG2 PAPSS2 DCXR	9.87e-05	185	58	4	0ff4148b4701003d9d594e0da8261176fb13aa59
ToppCell	Control-Myeloid-Macrophage_Alveolar\|World / Disease state, Lineage and Cell class	SLC12A6 MOGAT1 SLC47A1 ABCG2	9.87e-05	185	58	4	85cb81759589a26d83676cffbf2bc37399683c10
ToppCell	COVID-19-kidney-tDL\|kidney / Disease (COVID-19 only), tissue and cell type	RRAS2 FAT1 VPS13A SLC47A1	1.03e-04	187	58	4	d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCell	Club-club-14\|World / Class top	ABCC1 PDGFRA KCNK2 DCXR	1.03e-04	187	58	4	4584de577d3736c89187e522497498e58d381c46
ToppCell	(1)_Osterolineage_cells-(10)_OLC-1\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	FAT1 KCNK2 LHFPL6 NRP2	1.07e-04	189	58	4	46c5b975fb9d33017f2d9b7770d45a8bdf95baa2
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RRAS2 FAT1 EFCAB13 SLC47A1	1.07e-04	189	58	4	3b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT1 PDGFRA PAPSS2 NRP2	1.09e-04	190	58	4	2f54da2bee411f8868348a4c37034184b8f58a89
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_2\|356C / Donor, Lineage, Cell class and subclass (all cells)	SLC47A1 ABCG2 HSD17B14 NRP2	1.09e-04	190	58	4	4cce4ddb79b7751d0103e10f71156977e0c34439
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	EMC7 KIAA0319L LHFPL6 PRX	1.09e-04	190	58	4	651a1d3ae286e40f9d9f60e438211c6148d24143
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRA KCNK2 LHFPL6 NRP2	1.12e-04	191	58	4	806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCell	droplet-Kidney-nan-18m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRA KCNK2 SNTG1 LHFPL6	1.14e-04	192	58	4	38d7a24ae205ef91ed2e0f402d8022f2a9cdb243
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRA KCNK2 SNTG1 LHFPL6	1.14e-04	192	58	4	84149a5c6c3b3c9b86aed77cf8e72d99ef099fab
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRA KCNK2 SNTG1 LHFPL6	1.14e-04	192	58	4	04d155897ed075c359933080e36a4ab2150b6e9f
ToppCell	10x5'v1-week_17-19-Mesenchymal_osteo-stroma-early_osteoblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	FAT1 PDGFRA KCNK2 MPDZ	1.16e-04	193	58	4	5e46a9f65e85aca78f825fdef88a95b97eec8743
ToppCell	(1)_Osterolineage_cells\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	FAT1 KCNK2 LHFPL6 NRP2	1.16e-04	193	58	4	035eeea9f77c4bf9cd85f07fa791b6c857be76b5
ToppCell	IPF-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	LHFPL6 RRAS PAPSS2 PRX	1.19e-04	194	58	4	777ce41c3f22c591e2d81120f189b834e53ffb4b
ToppCell	Bronchus_Control_(B.)-Immune-TX-TRAM-1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	SLC12A6 SLC47A1 ABCG2 HSD17B14	1.21e-04	195	58	4	dabf667875ed48fdce4f803f5ead39c71a6df42b
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TULP4 VPS13C VPS13A PAPSS2	1.21e-04	195	58	4	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	facs-Thymus-Thymus_Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT1 PDGFRA KCNK2 LHFPL6	1.23e-04	196	58	4	6bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCell	facs-Thymus-Thymus_Epithelium-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT1 PDGFRA KCNK2 LHFPL6	1.23e-04	196	58	4	c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell	IPF-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	FAT1 RRAS PAPSS2 PRX	1.23e-04	196	58	4	8f0f72ead06abe02b575e443552eacc2151077ef
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LSR PRXL2A ABCG2 PAPSS2	1.26e-04	197	58	4	62c0a90869431e582bb7bb329e0b0cc59123d3d1
ToppCell	368C-Fibroblasts-Fibroblast-I\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	RRAS2 CTPS1 PAPSS2 NRP2	1.26e-04	197	58	4	a3d5225b2b0dd5199f3c3f86713a05d48f1be8f4
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	YEATS2 PAPSS2 PAPSS1 AGTPBP1	1.26e-04	197	58	4	8d5097898dd01cedb04cb694cb480c931e08462c
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LSR PRXL2A ABCG2 PAPSS2	1.26e-04	197	58	4	16f0eb047df9d702518f82ee99c6e7dc1350b2fb
ToppCell	(2)_5-FU-(3)_LEPR+_perivascular_cells\|World / Stress and Cell class	RRAS2 MPDZ LHFPL6 RRAS	1.26e-04	197	58	4	434ae0231972acba12d06279908cf407e70511ac
ToppCell	NS-critical-LOC-Myeloid-Macrophage\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PLOD3 RRAS PAPSS2 NRP2	1.26e-04	197	58	4	5fb0696376a5501b7c87e0f2f5e4fff3da2903f2
ToppCell	368C-Fibroblasts-Fibroblast-I-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	RRAS2 CTPS1 PAPSS2 NRP2	1.26e-04	197	58	4	d7a10eca2d810ab87dea570676f0b7041f99f017
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LSR PRXL2A ABCG2 PAPSS2	1.26e-04	197	58	4	9e948b2e0f7e426f1e6f95bbbf4282fbddc2b99d
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LSR PRXL2A LHFPL6 ABCG2	1.28e-04	198	58	4	0a4626b51ba8b52acbaf616f0ced850079cd7149
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT1 TMEM132A IFFO2 PRXL2A	1.28e-04	198	58	4	fc00cb25cdc6c31b7f9d397bc9f9a8f4e9708003
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LSR LHFPL6 ABCG2 PRX	1.31e-04	199	58	4	236b1417ed0875e98c6ec1ec714003bfce438d65
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT1 TMEM132A IFFO2 PRXL2A	1.31e-04	199	58	4	c88a28a73f54dc571f2ff1e4b55073f83cbead2c
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	COL9A1 FAT1 PDGFRA LHFPL6	1.31e-04	199	58	4	6b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	COL9A1 FAT1 PDGFRA LHFPL6	1.31e-04	199	58	4	e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	COL9A1 FAT1 PDGFRA LHFPL6	1.31e-04	199	58	4	38cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCell	distal-Endothelial-Capillary_Intermediate_1-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LHFPL6 RRAS PAPSS2 PRX	1.33e-04	200	58	4	43bc48413b100a06f8edd9acd812296788fcbf5b
ToppCell	medial-2-Endothelial-Capillary_Intermediate_1\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LHFPL6 RRAS PAPSS2 PRX	1.33e-04	200	58	4	a8adf5902540f6bb15b72efbb9c389b59d67e001
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	COL9A1 FAT1 PDGFRA LHFPL6	1.33e-04	200	58	4	08bf8c00eee6468215edb3611296bfc8784c4d56
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	COL9A1 FAT1 PDGFRA LHFPL6	1.33e-04	200	58	4	a9ff3210127000b3dd9e97136163c98c2b0817d7
ToppCell	distal-Endothelial-Capillary_Aerocyte\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LHFPL6 RRAS PAPSS2 PRX	1.33e-04	200	58	4	b91f8eb67752a77e1e08e462e50f1b5923695e1b
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LSR PRXL2A ABCG2 PRX	1.33e-04	200	58	4	86ec951234015ced7126b016199e5869a0f22478
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	COL9A1 FAT1 PDGFRA LHFPL6	1.33e-04	200	58	4	02cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	COL9A1 FAT1 PDGFRA LHFPL6	1.33e-04	200	58	4	9d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCell	medial-Endothelial-Capillary_Intermediate_1\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LHFPL6 RRAS PAPSS2 PRX	1.33e-04	200	58	4	3ef7b7728615710c691aed8977e2582f19692cf9
ToppCell	distal-1-Endothelial-Capillary_Aerocyte\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LHFPL6 RRAS PAPSS2 PRX	1.33e-04	200	58	4	59bacd738433cec6d05624a25fdfc087fb3ca3b5
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Macroglial-Astrocyte\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	COL9A1 FAT1 PDGFRA HSD17B14	1.33e-04	200	58	4	4fe3b2d80c567c18621bff3341f9a73578c81621
ToppCell	distal-Endothelial-Capillary_Aerocyte-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LHFPL6 RRAS PAPSS2 PRX	1.33e-04	200	58	4	0656906d16b0df19c0511965b5d18e9eab3cb168
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	COL9A1 FAT1 PDGFRA LHFPL6	1.33e-04	200	58	4	87827041663013f5e7273168dc8709d69840e7ce
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	COL9A1 FAT1 PDGFRA LHFPL6	1.33e-04	200	58	4	a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell	distal-Endothelial-Capillary_Intermediate_1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LHFPL6 RRAS PAPSS2 PRX	1.33e-04	200	58	4	4d6714d48738cdee7d535923f6dd2431e5304741
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	COL9A1 FAT1 PDGFRA LHFPL6	1.33e-04	200	58	4	09537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCell	distal-2-Endothelial-Capillary_Intermediate_1\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LHFPL6 RRAS PAPSS2 PRX	1.33e-04	200	58	4	7a99f28670ffb8ece7873d8a9bcd2a3936d0255d
ToppCell	medial-Endothelial-Capillary_Intermediate_1-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LHFPL6 RRAS PAPSS2 PRX	1.33e-04	200	58	4	707148e01e961097819a05437a842b7d3bf72b0a
ToppCell	Hippocampus-Macroglia-ASTROCYTE-Gja1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MOGAT1 PRXL2A PAPSS2	5.01e-04	119	58	3	79342c491a214c870ff6215da613db4a28c9d587
ToppCell	Hippocampus-Macroglia-ASTROCYTE\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MOGAT1 PRXL2A PAPSS2	5.01e-04	119	58	3	36857095d4e4cc6428d13bf7de04daec1f4cde1e
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FAT1 PRXL2A MPDZ	5.64e-04	124	58	3	36dfc702a570e1a1a6dde09f38badf9023ea7287
ToppCell	facs-Thymus-Epithelium-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MOGAT1 HSD17B14 PAPSS2	5.78e-04	125	58	3	6bdbbd47b699d836900bd055f2144cf960b5e7b6
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MOGAT1 MCCC2 PRX	6.48e-04	130	58	3	92913960e4367261ba08a405b61a421bc5e18169
ToppCell	facs-Thymus-Epithelium-3m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MOGAT1 HSD17B14 PAPSS2	6.77e-04	132	58	3	6f711fe84135406a8114a898a14c5ea0dfad74f2
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	RRAS2 COL9A1 CTPS1	7.54e-04	137	58	3	80f1a6cfb48ccfba1c3545fdcd5fcb3157272aca
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FAT1 PRXL2A MPDZ	7.86e-04	139	58	3	9e9f29f92dbe65b26cc78b3a1c00778c6a701f5b
Drug	mercaptoacetamide	ABCC1 PCSK7 PCSK4	2.69e-06	11	59	3	CID000012961
Drug	AC1NAX4S	PCSK7 PCSK4	6.60e-06	2	59	2	CID004459028
Drug	adenosine 5'-phosphoselenate	PAPSS2 PAPSS1	6.60e-06	2	59	2	CID000440758
Drug	beta-methylene-APS	PAPSS2 PAPSS1	6.60e-06	2	59	2	CID000129324
Drug	AC1L4BIC	ABCC1 SNTG1 ABCG2	9.04e-06	16	59	3	CID000153998
Drug	AC1NRBNZ	MBTPS1 KCNK2 PCSK7 NRP2	1.55e-05	58	59	4	CID005288543
Drug	zosuquidar	ABCC1 SNTG1 ABCG2	1.83e-05	20	59	3	CID000153997
Drug	taxane	ABCC1 ABCG2	1.98e-05	3	59	2	ctd:C080625
Drug	N-acetyldopamine	ABCC1 PAPSS2 PAPSS1	3.65e-05	25	59	3	CID000100526
Drug	AC1Q5O3Q	ABCC1 PCSK7 ABCG2	5.76e-05	29	59	3	CID000368335
Drug	AC1MIY5S	PAPSS2 PAPSS1	6.57e-05	5	59	2	CID003082099
Drug	NSC671054	ABCC1 ABCG2	6.57e-05	5	59	2	CID005357223
Drug	Cyclosporins	ABCC1 ABCG2	6.57e-05	5	59	2	ctd:D003524
Drug	acetaminophen sulfate	ABCG2 PAPSS2 PAPSS1	7.06e-05	31	59	3	CID000083939
Drug	AC1L8YYB	ABCC1 PCSK7 ABCG2	9.34e-05	34	59	3	CID000435167
Drug	D2-197	PCSK7 PCSK4	9.84e-05	6	59	2	CID000093175
Drug	bisbenzimide ethoxide trihydrochloride	ABCC1 ABCG2	9.84e-05	6	59	2	ctd:C017807
Drug	pyropheophorbide-a methyl ester	ABCC1 ABCG2	9.84e-05	6	59	2	CID005476777
Drug	Cefpiramide acid	ABCC1 ABCG2	9.84e-05	6	59	2	CID000002642
Drug	laniquidar	ABCC1 ABCG2	9.84e-05	6	59	2	CID006450806
Drug	N-succinyl-Ala-Ala-Pro-Leu-p-nitroanilide	PCSK7 PCSK4	9.84e-05	6	59	2	CID005044311
Drug	kaempferol	ABCC1 ABCG2 PAPSS2 PAPSS1	1.18e-04	97	59	4	CID005280863
Drug	CdAMP	ABCC1 ABCG2	1.37e-04	7	59	2	CID000168074
Drug	sulcofuron	RRAS2 RRAS	1.37e-04	7	59	2	CID000062506
Drug	KW-2149	ABCC1 PCSK7	1.37e-04	7	59	2	CID000108151
Drug	Minocycline hydrochloride [13614-98-7]; Down 200; 8uM; PC3; HT_HG-U133A	FMO5 TMEM132A VPS13A BCKDHB EML3	1.51e-04	195	59	5	5077_DN
Drug	O-acetylserine	MCCC2 PAPSS2 PAPSS1	1.53e-04	40	59	3	CID000000189
Drug	Glafenine hydrochloride [65513-72-6]; Down 200; 9.8uM; PC3; HT_HG-U133A	ABCC1 LSR TMEM132A LHFPL6 BCKDHB	1.54e-04	196	59	5	7257_DN
Drug	Tomatidine [77-59-8]; Up 200; 9.6uM; PC3; HT_HG-U133A	ABCC1 SNTG1 BCKDHB ABCG2 DBR1	1.54e-04	196	59	5	5808_UP
Drug	fluphenazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A_EA	MBTPS1 TMEM132A BCKDHB CTPS1 AGTPBP1	1.58e-04	197	59	5	1075_DN
Drug	Glycopyrrolate [596-51-0]; Down 200; 10uM; MCF7; HT_HG-U133A	ABCC1 SLC47A1 BCKDHB PAPSS2 EML3	1.62e-04	198	59	5	3427_DN
Drug	Cyclopentolate hydrochloride [5870-29-1]; Down 200; 12.2uM; HL60; HT_HG-U133A	FMO5 KIAA0319L LHFPL6 BCKDHB RRAS	1.66e-04	199	59	5	6132_DN
Drug	Ranitidine hydrochloride [66357-59-3]; Down 200; 11.4uM; PC3; HT_HG-U133A	MBTPS1 FMO5 TULP4 BCKDHB EML3	1.66e-04	199	59	5	6324_DN
Drug	Pimethixene maleate [13187-06-9]; Up 200; 9.8uM; HL60; HT_HG-U133A	TMEM132A TBC1D12 RRAS PAPSS2 PRX	1.69e-04	200	59	5	2395_UP
Drug	Rilmenidine hemifumarate [54187-04-1]; Up 200; 8.4uM; MCF7; HT_HG-U133A	SLC12A6 FMO5 PCSK7 SLC47A1 PRX	1.69e-04	200	59	5	5532_UP
Drug	Docetaxel trihydrate	ABCC1 PLOD3 ABCC12 ABCG2 DCXR	1.78e-04	202	59	5	CID000003143
Drug	senecioate	BCKDHB MCCC2	1.83e-04	8	59	2	CID000010931
Drug	OC144-093	ABCC1 ABCG2	1.83e-04	8	59	2	CID006450807
Drug	AC1L1C2F	RRAS2 COL9A1 PLOD3 RRAS	1.91e-04	110	59	4	CID000001711
Drug	magnesium pyrophosphate	PAPSS2 PAPSS1	2.35e-04	9	59	2	CID000122213
Drug	acetone cyanohydrin	PCSK7 PCSK4	2.35e-04	9	59	2	CID000006406
Drug	Fuda	PAPSS2 PAPSS1	2.35e-04	9	59	2	CID000266285
Drug	4'-methoxy-1-naphthylfenoterol	ABCC1 ABCG2	2.35e-04	9	59	2	ctd:C000603500
Drug	IAARh123	ABCC1 ABCG2	2.35e-04	9	59	2	CID000656577
Drug	MS-209	ABCC1 ABCG2	2.35e-04	9	59	2	CID000213040
Disease	Parkinson's disease 23 (implicated_via_orthology)	VPS13C VPS13A	3.67e-06	2	57	2	DOID:0060896 (implicated_via_orthology)
Disease	choreaacanthocytosis (implicated_via_orthology)	VPS13C VPS13A	3.67e-06	2	57	2	DOID:0050766 (implicated_via_orthology)
Disease	autosomal recessive spinocerebellar ataxia 4 (implicated_via_orthology)	VPS13C VPS13A	1.10e-05	3	57	2	DOID:0111611 (implicated_via_orthology)
Disease	Costello syndrome (implicated_via_orthology)	RRAS2 RRAS	1.10e-05	3	57	2	DOID:0050469 (implicated_via_orthology)
Disease	Cohen syndrome (implicated_via_orthology)	VPS13C VPS13A	1.10e-05	3	57	2	DOID:0111590 (implicated_via_orthology)
Disease	cerebellar ataxia (implicated_via_orthology)	VPS13C VPS13A	1.02e-04	8	57	2	DOID:0050753 (implicated_via_orthology)
Disease	RASopathy (implicated_via_orthology)	RRAS2 RRAS	1.31e-04	9	57	2	DOID:0080690 (implicated_via_orthology)
Disease	urinary bladder cancer (implicated_via_orthology)	RRAS2 RRAS	1.31e-04	9	57	2	DOID:11054 (implicated_via_orthology)
Disease	Disorder of organic acid metabolism	BCKDHB MCCC2	5.50e-04	18	57	2	cv:C1263739
Disease	Drug toxicity	ABCC1 ABCC12 ABCG2	5.83e-04	84	57	3	C0013221
Disease	Adverse reaction to drug	ABCC1 ABCC12 ABCG2	5.83e-04	84	57	3	C0041755
Disease	Juvenile Myelomonocytic Leukemia	RRAS2 RRAS	6.14e-04	19	57	2	C0349639
Disease	Noonan Syndrome	RRAS2 RRAS	9.85e-04	24	57	2	C0028326
Disease	interleukin-6 measurement	EFCAB13 KCNK2 SNTG1	1.34e-03	112	57	3	EFO_0004810

Protein segments in the cluster

Peptide	Gene	Start	Entry
KVIRATGGFGGGVGA	TBC1D12	31	O60347
SKVGTQFIRGVSGGE	ABCG2	176	Q9UNQ0
AGGGRRVSFLVTKGG	AGTPBP1	96	Q9UPW5
IGVEFGSRVVNVGGK	RAB4B	41	P61018
EGRVGEAKGGGVVSV	PALM3	206	A6NDB9
EQGIVGFGIGIAVTG	BCKDHB	126	P21953
GRVLGSGAFGKVVEG	PDGFRA	596	P16234
RGGDVARTVGGGQKV	PLOD3	76	O60568
GSGVGVFKIGEETGV	FAT1	1076	Q14517
EGGGNISVIVLGGAK	MOGAT1	176	Q96PD6
GQVVGTRGGFRGCTV	PAPSS2	31	O95340
LVVVFGGTGAQGGSV	NMRAL1	6	Q9HBL8
GGGIITGIGRVSGVE	MCCC2	116	Q9HCC0
IVTYGAGVRGSGVKG	MBTPS1	391	Q14703
QGKTQFGVGLRSGGE	KIAA0319L	56	Q8IZA0
GRSQLDSKGGVVGGT	KIAA1109	4456	Q2LD37
GVGDQLGTIFGKGIA	KCNK2	191	O95069
RGVTKGRGGLGTLFI	PCSK4	281	Q6UW60
GVIAGRQGFGSIFVV	PCSK7	311	Q16549
AGRRVLVTGAGKGIG	DCXR	6	Q7Z4W1
LVTGAGKGIGRGTVQ	DCXR	11	Q7Z4W1
VFEGVIGKGRSGEIA	NRP2	771	O60462
VSKTEILGGGRFGQV	MYLK4	106	Q86YV6
TVGRVAGGIQFLGGL	LHFPL6	116	Q9Y693
GQVVGTRGGFRGCTV	PAPSS1	41	O43252
TGVVLGGQVRTFGGK	ERVK-10	531	P87889
TGVVLGGQVRTFGGK	ERVK-19	531	Q9YNA8
TGVVLGGQVRTFGGK	ERVK-21	531	P62683
TGVVLGGQVRTFGGK	ERVK-24	531	P63145
TGVVLGGQVRTFGGK	ERVK-7	531	P63130
TGVVLGGQVRTFGGK	ERVK-8	531	P62685
TGVVLGGQVRTFGGK	ERVK-9	531	P63126
TGVVLGGQVRTFGGK	HERVK_113	531	P62684
NFVTLITGTGIGGGI	GNE	536	Q9Y223
EGFTGKRVIIIGIGN	FMO5	181	P49326
IRKFLGGVGSSNVGV	EFCAB13	366	Q8IY85
QVRRTGGGGVETVQG	IFFO2	166	Q5TF58
RYAGKVVVVTGGGRG	HSD17B14	6	Q9BPX1
VVVVTGGGRGIGAGI	HSD17B14	11	Q9BPX1
GVVKYRGVRIGGISG	DBR1	111	Q9UK59
GAQGLRGITGIVGDK	COL9A1	466	P20849
GGVGVPGNGTLTRKQ	EML3	436	Q32P44
GSGVGIGDRFKIEGR	EMC7	36	Q9NPA0
GKGLTIVGSVIVGNF	SLC12A6	786	Q9UHW9
LGVGTRNGSGKGRSV	LSR	6	Q86X29
VKQVIVVASGKGGVG	NUBPL	66	Q8TB37
TINGGEKVGIVGRTG	ABCC1	1316	P33527
GQGTGGKGVACITLA	SZT2	2286	Q5T011
QVAGSVGGNTGVRGK	TMEM132A	796	Q24JP5
RRQTVGGFGLSIKGG	SNTG1	61	Q9NSN8
GGFGVRGTEGKIQAI	CTPS1	371	P17812
RLVVVGGGGVGKSAL	RRAS2	16	P62070
GGGGVGKSALTIQFI	RRAS2	21	P62070
SGQTVGIVGRTGSGK	ABCC12	1146	Q96J65
LGGVFVVGSGKQGIL	PRXL2A	181	Q9BRX8
GGVLRGSGNQKVGAI	SLC47A1	396	Q96FL8
TGVVLGGQVRTFGGK	ERVK-9	531	P63128
GLVKGGVSAVAGGVT	TMEM263	81	Q8WUH6
LATGNGRGVVGVTFT	TULP4	46	Q9NRJ4
GGFGIRGTLGKLQAI	CTPS2	371	Q9NRF8
FREGITRGGKGLVSG	VPS13A	2956	Q96RL7
TRGGKGLVSGFVSGI	VPS13A	2961	Q96RL7
GLGFGIIGGKATGVI	MPDZ	266	O75970
DVGGIIGGTLQGFIS	SLC37A3	336	Q8NCC5
GKFVVVGGGIAGVTC	PYROXD1	11	Q8WU10
FAVRSGGATGVVVKG	RMC1	36	Q96DM3
GINVAGGGKEGIFVR	PRX	31	Q9BXM0
GKAGNLGGGVVTIER	RPL22	51	P35268
SLARGGKGFLRGVVG	VPS13C	3516	Q709C8
GKGFLRGVVGGVTGI	VPS13C	3521	Q709C8
GGGGVGKSALTIQFI	RRAS	36	P10301
GVAKAIVSGGGGTIV	YEATS2	696	Q9ULM3
GKLFVIGGARQGGVN	KLHL35	441	Q6PF15