Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	CABIT	GAREM2 GAREM1	3.55e-05	4	46	2	PF12736
Domain	CABIT_dom	GAREM2 GAREM1	3.55e-05	4	46	2	IPR025946
Domain	DUF4599	SPATA31D4 SPATA31D3	3.86e-04	12	46	2	PF15371
Domain	DUF4599	SPATA31D4 SPATA31D3	3.86e-04	12	46	2	IPR027970
Domain	Kringle	PLG PRSS12	7.88e-04	17	46	2	IPR000001
Domain	Kringle_CS	PLG PRSS12	7.88e-04	17	46	2	IPR018056
Domain	KRINGLE_2	PLG PRSS12	7.88e-04	17	46	2	PS50070
Domain	Kringle	PLG PRSS12	7.88e-04	17	46	2	PF00051
Domain	KRINGLE_1	PLG PRSS12	7.88e-04	17	46	2	PS00021
Domain	KR	PLG PRSS12	7.88e-04	17	46	2	SM00130
Domain	WD40_repeat_dom	ELP2 SPAG9 EML1 DENND3 UBR4	7.90e-04	297	46	5	IPR017986
Domain	-	ELP2 SPAG9 EML1 FBXW12 DENND3	1.32e-03	333	46	5	2.130.10.10
Domain	Quino_amine_DH_bsu	EML1 FBXW12	1.33e-03	22	46	2	IPR011044
Domain	WD40/YVTN_repeat-like_dom	ELP2 SPAG9 EML1 FBXW12 DENND3	1.35e-03	335	46	5	IPR015943
Domain	TRYPSIN_SER	MASP1 PLG PRSS12	1.41e-03	90	46	3	IPR033116
Domain	TRYPSIN_HIS	MASP1 PLG PRSS12	2.08e-03	103	46	3	IPR018114
Domain	TRYPSIN_SER	MASP1 PLG PRSS12	2.26e-03	106	46	3	PS00135
Domain	TRYPSIN_HIS	MASP1 PLG PRSS12	2.32e-03	107	46	3	PS00134
Domain	Peptidase_S1A	MASP1 PLG PRSS12	2.71e-03	113	46	3	IPR001314
Domain	Kringle-like	PLG PRSS12	2.81e-03	32	46	2	IPR013806
Domain	TRYPSIN_DOM	MASP1 PLG PRSS12	2.85e-03	115	46	3	PS50240
Domain	Tryp_SPc	MASP1 PLG PRSS12	2.99e-03	117	46	3	SM00020
Domain	Trypsin	MASP1 PLG PRSS12	3.29e-03	121	46	3	PF00089
Domain	Trypsin_dom	MASP1 PLG PRSS12	3.29e-03	121	46	3	IPR001254
Domain	Peptidase_S1_PA	MASP1 PLG PRSS12	3.44e-03	123	46	3	IPR009003
Domain	EGF_1	TENM1 LAMB4 MASP1 ADAM15	3.53e-03	255	46	4	PS00022
Domain	EGF-like_CS	TENM1 LAMB4 MASP1 ADAM15	3.84e-03	261	46	4	IPR013032
Domain	EGF_2	TENM1 LAMB4 MASP1 ADAM15	4.05e-03	265	46	4	PS01186
Domain	WD40_repeat	ELP2 EML1 FBXW12 DENND3	4.44e-03	272	46	4	IPR001680
Domain	WD_REPEATS_1	ELP2 EML1 FBXW12 DENND3	4.80e-03	278	46	4	PS00678
Domain	WD_REPEATS_2	ELP2 EML1 FBXW12 DENND3	4.86e-03	279	46	4	PS50082
Domain	WD_REPEATS_REGION	ELP2 EML1 FBXW12 DENND3	4.86e-03	279	46	4	PS50294
Domain	ARM-type_fold	CTIF HEATR6 UBR4 IPO11	9.55e-03	339	46	4	IPR016024
Domain	EGF_extracell	TENM1 ADAM15	9.59e-03	60	46	2	IPR013111
Domain	EGF_2	TENM1 ADAM15	9.59e-03	60	46	2	PF07974
Pubmed	Role of the teneurins, teneurin C-terminal associated peptides (TCAP) in reproduction: clinical perspectives.	TENM1 ADGRL1	1.87e-06	2	48	2	26485751
Pubmed	Plasminogen is a key proinflammatory regulator that accelerates the healing of acute and diabetic wounds.	PLG LEPR	5.59e-06	3	48	2	22563086
Pubmed	Mannose-binding lectin-associated serine protease-1 cleaves plasminogen and plasma fibronectin: prefers plasminogen over known fibrinogen substrate.	MASP1 PLG	5.59e-06	3	48	2	34650023
Pubmed	Sex Hormone-Binding Globulin Reduction in Metabolic Disorders May Play a Role in NAFLD Development.	LEPR SHBG	5.59e-06	3	48	2	28359088
Pubmed	A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling.	GAREM2 GAREM1	1.12e-05	4	48	2	24003223
Pubmed	SHBG-C57BL/ksJ-db/db: A New Mouse Model to Study SHBG Expression and Regulation During Obesity Development.	LEPR SHBG	1.12e-05	4	48	2	26441241
Pubmed	Activation of p38alpha/beta MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo.	SPAG9 CDON	1.86e-05	5	48	2	17074887
Pubmed	ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation.	SPAG9 CDON	1.86e-05	5	48	2	34686700
Pubmed	Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway.	SPAG9 CDON	1.86e-05	5	48	2	19244314
Pubmed	N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts.	SPAG9 CDON	1.86e-05	5	48	2	20160094
Pubmed	Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation.	SPAG9 CDON	2.79e-05	6	48	2	19470755
Pubmed	A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation.	SPAG9 CDON	3.90e-05	7	48	2	18678706
Pubmed	Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.	TENM1 ADGRL1	8.33e-05	10	48	2	38713721
Pubmed	Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.	NEDD9 PLG PRDX1 SHBG	1.11e-04	179	48	4	18624398
Pubmed	IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration.	ELP2 PRDX1	1.94e-04	15	48	2	18303054
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	FLG MASP1 MID2 FBXW12 GLG1 MTM1	3.50e-04	686	48	6	29987050
Pubmed	Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.	SPAG9 CDON	5.05e-04	24	48	2	15923648
Pubmed	Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.	MID2 UBR4	6.89e-04	28	48	2	35474067
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	NEDD9 ADGRL1 SPAG9	8.34e-04	133	48	3	15144186
Pubmed	Splicing Regulator p54nrb /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma.	SPAG9 ADAM15	9.01e-04	32	48	2	31815296
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TMEM63B ZNF638 ADGRL1 NMNAT2 CTIF MID2 LRRC41 USP40	9.07e-04	1489	48	8	28611215
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	ELP2 TMEM214 GLG1 LRRC41 IPO11	1.03e-03	560	48	5	35241646
Pubmed	Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins.	FLG PRDX1	1.27e-03	38	48	2	23537643
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	MTM1 UBR4 IPO11 PRDX1	1.30e-03	344	48	4	30333137
Interaction	GAREM2 interactions	TENM1 GAREM2 GAREM1	1.81e-06	11	46	3	int:GAREM2
Cytoband	9q21.32	SPATA31D4 SPATA31D3	1.81e-04	19	48	2	9q21.32
Cytoband	Xq25	TENM1 TEX13C	8.55e-04	41	48	2	Xq25
Cytoband	Ensembl 112 genes in cytogenetic band chrXq25	TENM1 TEX13C	1.17e-03	48	48	2	chrXq25
Cytoband	1p34.1	LRRC41 PRDX1	1.65e-03	57	48	2	1p34.1
Cytoband	2p23.3	TMEM214 GAREM2	2.33e-03	68	48	2	2p23.3
Cytoband	Ensembl 112 genes in cytogenetic band chr18q12	ELP2 GAREM1	5.36e-03	104	48	2	chr18q12
GeneFamily	WD repeat domain containing	ELP2 EML1 FBXW12 DENND3	5.82e-04	262	27	4	362
GeneFamily	Proteases, serine	MASP1 PRSS12	3.97e-03	63	27	2	738
Drug	Aminohippuric acid [61-78-9]; Up 200; 20.6uM; MCF7; HT_HG-U133A	NMNAT2 CTIF ORAI2 GLG1 LEPR SNTB1	3.11e-06	197	47	6	5394_UP
Drug	Bezafibrate [41859-67-0]; Down 200; 11uM; MCF7; HT_HG-U133A	SMYD5 ITPRID2 GLG1 ADAM15 LEPR MTM1	3.20e-06	198	47	6	4999_DN
Drug	NSC37726	ITPRID2 SHBG	1.25e-05	3	47	2	CID000003302
Drug	Salbutamol [18559-94-9]; Down 200; 16.8uM; PC3; HT_HG-U133A	NEDD9 MID2 DENND3 MTM1 CDON	4.54e-05	191	47	5	7376_DN
Drug	Dilazep dihydrochloride [20153-98-4]; Down 200; 6uM; PC3; HT_HG-U133A	NMNAT2 EML1 ORAI2 DENND3 CDON	4.77e-05	193	47	5	7364_DN
Drug	F0447-0125; Down 200; 10uM; MCF7; HT_HG-U133A	NEDD9 ITPRID2 ORAI2 MTM1 LRRC41	5.01e-05	195	47	5	6424_DN
Drug	Cromolyn disodium salt [15826-37-6]; Down 200; 7.8uM; PC3; HT_HG-U133A	DENND3 MARCHF3 MTM1 CDON GAREM1	5.14e-05	196	47	5	5754_DN
Drug	Pantothenic acid calcium salt monohydrate [63409-48-3]; Down 200; 8uM; MCF7; HT_HG-U133A	NEDD9 EML1 LEPR LRRC41 GAREM1	5.14e-05	196	47	5	3248_DN
Drug	Isocarboxazid [59-63-2]; Down 200; 17.2uM; PC3; HT_HG-U133A	NEDD9 ORAI2 DENND3 MTM1 CDON	5.26e-05	197	47	5	7383_DN
Drug	Azathymine, 6 [932-53-6]; Down 200; 31.4uM; PC3; HT_HG-U133A	NEDD9 ADGRL1 ORAI2 DENND3 CDON	5.39e-05	198	47	5	3987_DN
Drug	(-)-Eseroline fumarate salt [104015-29-4]; Down 200; 12uM; PC3; HT_HG-U133A	ADGRL1 MID2 GLG1 DENND3 MTM1	5.52e-05	199	47	5	7267_DN
Drug	Moxisylyte hydrochoride [964-52-3]; Up 200; 12.6uM; PC3; HT_HG-U133A	NEDD9 ADGRL1 EML1 HEATR6 CDON	5.52e-05	199	47	5	1804_UP
Drug	P-79	NEDD9 GLG1 LEPR	6.10e-05	37	47	3	CID003035294
Disease	Keloid	MYDGF PRDX1	1.20e-03	35	43	2	C0022548
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	EML1 SNTB1	1.27e-03	36	43	2	DOID:11723 (implicated_via_orthology)
Disease	serum albumin measurement	TMEM63B SPAG9 ADAM15 LEPR MTM1	1.64e-03	592	43	5	EFO_0004535
Disease	pneumonia	NEDD9 MYDGF	2.15e-03	47	43	2	EFO_0003106
Disease	Varicose veins	STAC2 GLG1 ADAM15	2.80e-03	193	43	3	HP_0002619
Disease	plasminogen activator inhibitor 1 measurement	PLG UBR4	2.83e-03	54	43	2	EFO_0004792
Disease	left ventricular diastolic function measurement	DENND3 GAREM1	2.83e-03	54	43	2	EFO_0008204
Disease	complement factor H-related protein 1 measurement	NEDD9 KIAA1549L	3.04e-03	56	43	2	EFO_0600054
Disease	cup-to-disc ratio measurement	NEDD9 KIAA1549L GLG1 ADAM15	3.50e-03	430	43	4	EFO_0006939

Protein segments in the cluster

Peptide	Gene	Start	Entry
SERTQSHISQWTADC	CTIF	51	O43310
QTSHDLNECSWSLNI	NEDD9	501	Q14511
GHTCALSWRESVHTQ	ADAM15	176	Q13444
TSTHESEHQSGAWCK	ADGRL1	151	O94910
LEGTSHCHINLDETW	ANKRD18B	651	A2A2Z9
QVSTHEQSESSHGWT	FLG	2741	P20930
VTVFNASSWTIHQHS	DENND3	926	A2RUS2
ELVTSNHHSVQALSW	ORAI2	36	Q96SN7
QEELSSLVWICTSTH	SPAG9	751	O60271
IQFQSSHVWTDDLSH	OTOA	56	Q7RTW8
SSHWDDSDASVICHQ	PRSS12	196	P56730
ACSLWNHHTDTFLQE	IPO11	181	Q9UI26
HQHIQVSTSSACVWQ	LBHD1	46	Q9BQE6
LENTWHDHTTDSCIS	FBXW12	421	Q6X9E4
HSCRQWTTITAHSLE	GAREM1	56	Q9H706
SAIHQCSSWTHREIL	HEATR6	126	Q6AI08
INHHTSCNGTWSEDV	LEPR	681	P48357
KSTCHWEVHNVSTVT	CD200R1	201	Q8TD46
WEVHNVSTVTCHVSH	CD200R1	206	Q8TD46
DLNGHTISTTSWETH	KIAA1549L	426	Q6ZVL6
QSTCSLHSIHSEWQE	ITPRID2	841	P28290
ASVDSHFCHLAWVNT	PRDX1	76	Q06830
ASRLCHTHGWNETSE	GLG1	571	Q92896
SCAHSETEINIVSWN	CDON	1236	Q4KMG0
SSCSESLHISNWTVS	TMEM63B	396	Q5T3F8
IHRSCLEHWLSSSNT	MARCHF3	96	Q86UD3
GSSWIVTAAHCLHQS	MASP1	481	P48740
HLCFDQWDHTISSLS	LAMB4	1176	A4D0S4
HSSFITHLDWSVNSQ	EML1	671	O00423
WTHCVETSQSQSHTL	ELP2	766	Q6IA86
LIHSCRQWTTVTAHT	GAREM2	51	Q75VX8
LSHWTRSIVQGCHNS	SNTB1	421	Q13884
TCHVVSDSWDSSQAF	LRRC41	791	Q15345
DQALNRSHEIWTHSC	SHBG	376	P04278
TSTQDSVHLHNSWVL	TENM1	236	Q9UKZ4
TVHSSWHSVKQTICL	SPATA31D4	846	Q6ZUB0
NVAVTVSGHTCQHWS	PLG	286	P00747
TVHSSWHSVKQTICL	SPATA31D3	846	P0C874
NVEESHWLSSLESTH	MTM1	331	Q13496
VSVHLWCSEEISHQQ	STAC2	146	Q6ZMT1
WAHTNATVSFLSAHC	TMEM214	566	Q6NUQ4
HVEECQATSWALTSQ	TEX13C	96	A0A0J9YWL9
RQGTVHIHTSSVSCW	FP248	81	Q71RG6
LCTASHDTITVHWIS	MID2	411	Q9UJV3
IGTSSLSQWVHACDT	SMYD5	256	Q6GMV2
SSSVRWQAHCLTLHI	UBR4	3421	Q5T4S7
GHWESHQDQTNCTSS	USP40	946	Q9NVE5
WIQHQNTSTHIESCR	ZNF638	441	Q14966
LGTSEDHQHFTCTIW	MYDGF	81	Q969H8
TWQTTCSVLEHHRDL	NMNAT2	91	Q9BZQ4