Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of postsynaptic actin cytoskeleton	POTEE POTEI POTEJ POTEF	6.69e-09	11	44	4	GO:0098973
GeneOntologyMolecularFunction	structural constituent of postsynapse	POTEE POTEI POTEJ POTEF	7.05e-07	32	44	4	GO:0099186
GeneOntologyMolecularFunction	structural constituent of synapse	POTEE POTEI POTEJ POTEF	2.16e-06	42	44	4	GO:0098918
GeneOntologyMolecularFunction	structural constituent of cytoskeleton	POTEE POTEI POTEJ POTEF	1.90e-04	130	44	4	GO:0005200
GeneOntologyBiologicalProcess	postsynaptic actin cytoskeleton organization	POTEE POTEI POTEJ POTEF	4.94e-07	31	43	4	GO:0098974
GeneOntologyBiologicalProcess	postsynaptic cytoskeleton organization	POTEE POTEI POTEJ POTEF	8.18e-07	35	43	4	GO:0099188
GeneOntologyBiologicalProcess	positive regulation of neuron projection arborization	DVL2 DVL3	1.18e-04	8	43	2	GO:0150012
GeneOntologyCellularComponent	H4 histone acetyltransferase complex	POTEE MSL1 POTEI POTEJ POTEF	3.75e-08	45	44	5	GO:1902562
GeneOntologyCellularComponent	H4/H2A histone acetyltransferase complex	POTEE POTEI POTEJ POTEF	5.88e-07	32	44	4	GO:0043189
GeneOntologyCellularComponent	NuA4 histone acetyltransferase complex	POTEE POTEI POTEJ POTEF	5.88e-07	32	44	4	GO:0035267
GeneOntologyCellularComponent	histone acetyltransferase complex	POTEE MSL1 POTEI POTEJ POTEF	1.56e-06	94	44	5	GO:0000123
GeneOntologyCellularComponent	protein acetyltransferase complex	POTEE MSL1 POTEI POTEJ POTEF	2.58e-06	104	44	5	GO:0031248
GeneOntologyCellularComponent	acetyltransferase complex	POTEE MSL1 POTEI POTEJ POTEF	3.25e-06	109	44	5	GO:1902493
GeneOntologyCellularComponent	actin filament	POTEE POTEI POTEJ POTEF VCL	1.35e-05	146	44	5	GO:0005884
GeneOntologyCellularComponent	intracellular protein-containing complex	POTEE WDR18 CCT4 MSL1 POTEI POTEJ FBXO21 POTEF CDC23	1.60e-04	972	44	9	GO:0140535
GeneOntologyCellularComponent	polymeric cytoskeletal fiber	CLIP4 POTEE CCT4 POTEI POTEJ POTEF VCL	2.53e-03	899	44	7	GO:0099513
GeneOntologyCellularComponent	supramolecular fiber	CLIP4 POTEE CCT4 POTEI POTEJ POTEF SPHKAP VCL	2.88e-03	1179	44	8	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	CLIP4 POTEE CCT4 POTEI POTEJ POTEF SPHKAP VCL	3.01e-03	1187	44	8	GO:0099081
GeneOntologyCellularComponent	transferase complex	POTEE MSL1 POTEI POTEJ FBXO21 POTEF CDC23	3.71e-03	963	44	7	GO:1990234
Domain	Ankyrin_rpt	CLIP4 POTEB3 POTEE POTEI POTEJ POTEB2 POTEM POTEH POTEB POTEF POTEC MRM1 POTEG	2.13e-14	262	44	13	IPR002110
Domain	ANK	CLIP4 POTEB3 POTEE POTEI POTEJ POTEB2 POTEM POTEH POTEB POTEF POTEC POTEG	3.84e-13	251	44	12	SM00248
Domain	ANK_REPEAT	CLIP4 POTEB3 POTEE POTEI POTEJ POTEB2 POTEM POTEH POTEB POTEF POTEC POTEG	4.22e-13	253	44	12	PS50088
Domain	Ankyrin_rpt-contain_dom	CLIP4 POTEB3 POTEE POTEI POTEJ POTEB2 POTEM POTEH POTEB POTEF POTEC POTEG	4.43e-13	254	44	12	IPR020683
Domain	ANK_REP_REGION	CLIP4 POTEB3 POTEE POTEI POTEJ POTEB2 POTEM POTEH POTEB POTEF POTEC POTEG	4.43e-13	254	44	12	PS50297
Domain	Ank_2	CLIP4 POTEB3 POTEE POTEI POTEJ POTEB2 POTEM POTEH POTEF POTEC POTEG	2.00e-12	215	44	11	PF12796
Domain	-	CLIP4 POTEB3 POTEE POTEI POTEJ POTEB2 POTEM POTEH POTEF POTEC POTEG	9.45e-12	248	44	11	1.25.40.20
Domain	Ank	CLIP4 POTEE POTEI POTEJ POTEM POTEH POTEB POTEF POTEC POTEG	1.04e-10	228	44	10	PF00023
Domain	Actin_CS	POTEE POTEI POTEJ POTEF	4.78e-08	16	44	4	IPR004001
Domain	ACTINS_2	POTEE POTEI POTEJ POTEF	6.23e-08	17	44	4	PS00432
Domain	Actin/actin-like_CS	POTEE POTEI POTEJ POTEF	8.00e-08	18	44	4	IPR020902
Domain	ACTINS_ACT_LIKE	POTEE POTEI POTEJ POTEF	1.01e-07	19	44	4	PS01132
Domain	Actin	POTEE POTEI POTEJ POTEF	8.05e-07	31	44	4	IPR004000
Domain	Actin	POTEE POTEI POTEJ POTEF	8.05e-07	31	44	4	PF00022
Domain	ACTIN	POTEE POTEI POTEJ POTEF	8.05e-07	31	44	4	SM00268
Domain	Dsh_C	DVL2 DVL3	1.62e-05	3	44	2	PF12316
Domain	Dishevelled_C-dom	DVL2 DVL3	1.62e-05	3	44	2	IPR024580
Domain	Dishevelled	DVL2 DVL3	3.24e-05	4	44	2	PF02377
Domain	Dsh/Dvl-rel	DVL2 DVL3	3.24e-05	4	44	2	IPR015506
Domain	Dishevelled_protein_dom	DVL2 DVL3	3.24e-05	4	44	2	IPR003351
Domain	Dishevelled_fam	DVL2 DVL3	3.24e-05	4	44	2	IPR008339
Domain	DIX	DVL2 DVL3	1.13e-04	7	44	2	IPR001158
Domain	DIX	DVL2 DVL3	1.13e-04	7	44	2	PS50841
Domain	DAX	DVL2 DVL3	1.13e-04	7	44	2	SM00021
Domain	DIX	DVL2 DVL3	1.13e-04	7	44	2	PF00778
Domain	Ubiquitin-rel_dom	DVL2 DVL3 DDI2 USP24	9.10e-04	184	44	4	IPR029071
Domain	DEP	DVL2 DVL3	1.22e-03	22	44	2	PF00610
Domain	DEP	DVL2 DVL3	1.22e-03	22	44	2	SM00049
Domain	DEP	DVL2 DVL3	1.22e-03	22	44	2	PS50186
Domain	DEP_dom	DVL2 DVL3	1.33e-03	23	44	2	IPR000591
Domain	TPR_8	TOMM70 CDC23	6.93e-03	53	44	2	PF13181
Pathway	REACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_DVL_INTERACTING_PROTEINS	DVL2 DVL3	3.26e-05	5	26	2	M27447
Pathway	REACTOME_WNT_MEDIATED_ACTIVATION_OF_DVL	DVL2 DVL3	9.10e-05	8	26	2	M27100
Pathway	REACTOME_WNT_MEDIATED_ACTIVATION_OF_DVL	DVL2 DVL3	1.17e-04	9	26	2	MM14792
Pathway	REACTOME_KILLING_MECHANISMS	DVL2 DVL3	2.13e-04	12	26	2	M29844
Pathway	KEGG_PATHWAYS_IN_CANCER	DVL2 DVL3 TPR BIRC2 FH	2.79e-04	325	26	5	M12868
Pathway	KEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY	DVL2 DVL3	3.86e-04	16	26	2	M47823
Pathway	PID_BETA_CATENIN_DEG_PATHWAY	DVL2 DVL3	4.91e-04	18	26	2	M31
Pathway	PID_WNT_CANONICAL_PATHWAY	DVL2 DVL3	6.09e-04	20	26	2	M90
Pubmed	The Vertebrate Genome Annotation browser 10 years on.	POTEB3 POTEE POTEI POTEJ POTEB2 POTEM MUC17 POTEH POTEB POTEF POTEC POTEG	1.38e-18	163	44	12	24316575
Pubmed	Two novel transcripts encoding two Ankyrin repeat containing proteins have preponderant expression during the mouse spermatogenesis.	POTEB2 POTEM POTEH POTEB POTEC POTEG	2.87e-18	6	44	6	17171436
Pubmed	POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.	POTEB3 POTEJ POTEB2 POTEH POTEB POTEC	8.03e-17	8	44	6	12475935
Pubmed	Identification of a novel actin isoform in hepatocellular carcinoma.	POTEE POTEI POTEJ POTEM POTEF POTEG	1.43e-14	15	44	6	16824795
Pubmed	Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.	POTEB3 POTEE POTEH POTEB POTEG	5.37e-14	7	44	5	15276201
Pubmed	Identification and characterization of TSAP, a novel gene specifically expressed in testis during spermatogenesis.	POTEM POTEH POTEB POTEC	2.23e-12	4	44	4	17342726
Pubmed	Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.	POTEE POTEI POTEJ POTEM	2.79e-10	9	44	4	16364570
Pubmed	Evolution and expression of chimeric POTE-actin genes in the human genome.	POTEE POTEJ POTEF	1.89e-09	3	44	3	17101985
Pubmed	Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.	POTEE LTF POTEI POTEJ POTEF	1.44e-07	96	44	5	23580065
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	TPR POTEE POTEI POTEJ POTEF EIF3CL	1.17e-06	271	44	6	32433965
Pubmed	Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.	POTEE LTF POTEI POTEJ POTEF	1.28e-06	149	44	5	22664934
Pubmed	Genetic analysis of disheveled 2 and disheveled 3 in human neural tube defects.	DVL2 DVL3	1.56e-06	2	44	2	22892949
Pubmed	Planar polarization of node cells determines the rotational axis of node cilia.	DVL2 DVL3	1.56e-06	2	44	2	20098415
Pubmed	A primate-specific POTE-actin fusion protein plays a role in apoptosis.	POTEE POTEF	1.56e-06	2	44	2	19669888
Pubmed	Disheveled proteins promote cell growth and tumorigenicity in ALK-positive anaplastic large cell lymphoma.	DVL2 DVL3	1.56e-06	2	44	2	23022960
Pubmed	Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells.	POTEE POTEJ	1.56e-06	2	44	2	18447647
Pubmed	Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling.	DVL2 DVL3	4.69e-06	3	44	2	21092292
Pubmed	Dishevelled stability is positively regulated by PKCζ-mediated phosphorylation induced by Wnt agonists.	DVL2 DVL3	4.69e-06	3	44	2	28366812
Pubmed	Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3.	DVL2 DVL3	4.69e-06	3	44	2	18093802
Pubmed	Genomic organization of mouse Dishevelled genes.	DVL2 DVL3	4.69e-06	3	44	2	8973355
Pubmed	Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression.	DVL2 DVL3	4.69e-06	3	44	2	18692936
Pubmed	DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway.	DVL2 DVL3	4.69e-06	3	44	2	32900645
Pubmed	Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.	DVL2 DVL3	4.69e-06	3	44	2	27744318
Pubmed	Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia.	DVL2 DVL3	4.69e-06	3	44	2	27086035
Pubmed	Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma.	DVL2 DVL3	4.69e-06	3	44	2	19137009
Pubmed	Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals.	DVL2 DVL3	4.69e-06	3	44	2	23437169
Pubmed	Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.	DVL2 DVL3	9.37e-06	4	44	2	24643799
Pubmed	DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.	DVL2 DVL3	9.37e-06	4	44	2	25557784
Pubmed	cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.	DVL2 DVL3	9.37e-06	4	44	2	8817329
Pubmed	Human dishevelled genes constitute a DHR-containing multigene family.	DVL2 DVL3	9.37e-06	4	44	2	9192851
Pubmed	Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways.	DVL2 DVL3	9.37e-06	4	44	2	17593335
Pubmed	Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways.	DVL2 DVL3	9.37e-06	4	44	2	19625296
Pubmed	Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus.	DVL2 DVL3	9.37e-06	4	44	2	25043421
Pubmed	Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein.	DVL2 DVL3	9.37e-06	4	44	2	19465938
Pubmed	Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling.	DVL2 DVL3	9.37e-06	4	44	2	23371553
Pubmed	Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation.	DVL2 DVL3	9.37e-06	4	44	2	18772438
Pubmed	Association between LTF/MMP20/CA6/TAS1R2 polymorphisms and susceptibility to dental caries.	LTF MMP20	9.37e-06	4	44	2	39212776
Pubmed	Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled.	DVL2 DVL3	1.56e-05	5	44	2	20137080
Pubmed	Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.	DVL2 DVL3	1.56e-05	5	44	2	15456783
Pubmed	Personalized copy number and segmental duplication maps using next-generation sequencing.	POTEB3 POTEB	1.56e-05	5	44	2	19718026
Pubmed	A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.	DVL2 DVL3	1.56e-05	5	44	2	25424568
Pubmed	CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation.	DVL2 DVL3	1.56e-05	5	44	2	24469800
Pubmed	The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.	DVL2 DVL3	1.56e-05	5	44	2	22826439
Pubmed	High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-β and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner.	DVL2 DVL3	2.34e-05	6	44	2	24427302
Pubmed	Deletion of the Dishevelled family of genes disrupts anterior-posterior axis specification and selectively prevents mesoderm differentiation.	DVL2 DVL3	2.34e-05	6	44	2	32579954
Pubmed	Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.	DVL2 DVL3	2.34e-05	6	44	2	34139860
Pubmed	Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation.	DVL2 DVL3	2.34e-05	6	44	2	21880741
Pubmed	SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.	DVL2 DVL3	2.34e-05	6	44	2	20439735
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DVL2 TPR WDR18 CCT4 TRIM67 CAMKV TBL1Y SPHKAP	2.46e-05	963	44	8	28671696
Pubmed	CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.	POTEE CCT4 POTEI POTEJ POTEF	3.14e-05	288	44	5	31501420
Pubmed	Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells.	DVL2 DVL3	3.27e-05	7	44	2	10806215
Pubmed	Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.	DVL2 DVL3	3.27e-05	7	44	2	19008950
Pubmed	Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling.	DVL2 DVL3	3.27e-05	7	44	2	17005174
Pubmed	The ubiquitin ligase PDZRN3 is required for vascular morphogenesis through Wnt/planar cell polarity signalling.	DVL3 NDOR1	3.27e-05	7	44	2	25198863
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	TPR CCT4 POTEI POTEJ POTEF VCL	4.07e-05	506	44	6	30890647
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	WDR18 TBL1Y CDC23 EIF3CL	4.26e-05	153	44	4	26365490
Pubmed	Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.	DVL2 DVL3	4.36e-05	8	44	2	15454084
Pubmed	Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.	DVL2 DVL3	4.36e-05	8	44	2	19388021
Pubmed	Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1.	DVL2 DVL3	4.36e-05	8	44	2	12165471
Pubmed	RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer.	DVL2 DVL3	5.60e-05	9	44	2	32965059
Pubmed	Expression of planar cell polarity genes during development of the mouse CNS.	DVL2 DVL3	5.60e-05	9	44	2	16487141
Pubmed	Regulation of the Wnt signaling pathway by disabled-2 (Dab2).	DVL2 DVL3	5.60e-05	9	44	2	12805222
Pubmed	The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.	DVL3 TPR CCT4 LTF POTEJ	5.98e-05	330	44	5	32529326
Pubmed	Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract.	DVL2 DVL3	6.99e-05	10	44	2	15637299
Pubmed	Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons.	DVL2 DVL3	6.99e-05	10	44	2	23109420
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	TPR CCT4 VCL EIF3CL USP24	7.28e-05	344	44	5	30333137
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	TOMM70 LTF VCL EIF3CL	7.84e-05	179	44	4	36261009
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	DVL2 DVL3 TPR CCT4 CAMKV SPHKAP EIF3CL USP24	8.02e-05	1139	44	8	36417873
Pubmed	Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription.	DVL2 DVL3	8.54e-05	11	44	2	10644691
Pubmed	Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.	DVL2 DVL3	1.02e-04	12	44	2	12421720
Pubmed	Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture.	DVL2 DVL3	1.02e-04	12	44	2	18824165
Pubmed	Microtubules enable the planar cell polarity of airway cilia.	DVL2 DVL3	1.02e-04	12	44	2	23122850
Pubmed	Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.	CCT4 VCL CDC23 EIF3CL	1.14e-04	197	44	4	32434143
Pubmed	The Hippo pathway regulates Wnt/beta-catenin signaling.	DVL2 DVL3	1.21e-04	13	44	2	20412773
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	DVL2 TPR POTEJ POTEF	1.25e-04	202	44	4	24639526
Pubmed	Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region.	DVL2 DVL3	1.41e-04	14	44	2	12433684
Pubmed	PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium.	DVL2 VCL	1.41e-04	14	44	2	22560610
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	DVL2 DVL3 TPR VCL	1.62e-04	216	44	4	31519766
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TPR WDR18 LTF FH VCL USP24	1.65e-04	653	44	6	22586326
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	DVL2 DVL3 TPR	1.80e-04	86	44	3	37253089
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	DVL2 DVL3 TPR CDC23 USP24	1.81e-04	418	44	5	34709266
Pubmed	The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled.	DVL2 DVL3	1.86e-04	16	44	2	22771245
Pubmed	Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling.	BIRC2 VCL	1.86e-04	16	44	2	19004856
Pubmed	Wnts regulate planar cell polarity via heterotrimeric G protein and PI3K signaling.	DVL2 DVL3	2.10e-04	17	44	2	32805026
Pubmed	Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled protein.	DVL2 DVL3	2.10e-04	17	44	2	20970343
Pubmed	MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.	TPR MSL1	2.10e-04	17	44	2	20479123
Pubmed	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.	CCT4 KCNE4 POTEI POTEJ POTEF	2.34e-04	442	44	5	15815621
Pubmed	GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation.	DVL2 DVL3	2.36e-04	18	44	2	25073924
Pubmed	Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak.	DVL2 DVL3	2.36e-04	18	44	2	19701191
Pubmed	SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243.	POTEE CCT4 POTEF	2.41e-04	95	44	3	33863777
Pubmed	WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels.	DVL2 LTF USP24	2.56e-04	97	44	3	25071155
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	DVL2 DVL3 TPR CCT4	3.09e-04	256	44	4	33397691
Pubmed	An inter-species protein-protein interaction network across vast evolutionary distance.	DVL2 DVL3 BIRC2 FH CDC23	3.52e-04	483	44	5	27107014
Pubmed	MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus.	DVL2 VCL	3.56e-04	22	44	2	34032267
Pubmed	p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells.	POTEE POTEJ	3.56e-04	22	44	2	25331947
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	CCT4 MSL1 LTF FBXO21 AHDC1	3.93e-04	495	44	5	27705803
Pubmed	Atmin mediates kidney morphogenesis by modulating Wnt signaling.	DVL2 DVL3	4.24e-04	24	44	2	24852369
Pubmed	Regulation of planar cell polarity by Smurf ubiquitin ligases.	DVL2 DVL3	4.61e-04	25	44	2	19379695
Pubmed	C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.	TPR CCT4 FH	4.67e-04	119	44	3	35776542
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	TPR WDR18 MSL1 LTF VCL CDC23 EIF3CL	5.72e-04	1155	44	7	20360068
Interaction	POTEG interactions	POTEH POTEF POTEC POTEG	8.78e-09	12	43	4	int:POTEG
Interaction	POTEC interactions	POTEB3 POTEF POTEC POTEG	1.27e-08	13	43	4	int:POTEC
Interaction	ACTG2 interactions	POTEE POTEI TRIM67 POTEJ POTEF	6.19e-08	49	43	5	int:ACTG2
Interaction	PFDN2 interactions	POTEE WDR18 CCT4 POTEI TRIM67 POTEJ POTEF	8.44e-07	247	43	7	int:PFDN2
Interaction	POTEB3 interactions	POTEB3 POTEB2 POTEF POTEC	8.96e-07	35	43	4	int:POTEB3
Interaction	POTEH interactions	POTEH POTEG	4.45e-06	2	43	2	int:POTEH
Interaction	CAP2 interactions	POTEI TRIM67 POTEJ POTEF	1.18e-05	66	43	4	int:CAP2
Interaction	ACTG1 interactions	TPR POTEE CCT4 POTEI TRIM67 POTEJ POTEF VCL	1.22e-05	520	43	8	int:ACTG1
Interaction	ACTA1 interactions	POTEE CCT4 POTEI TRIM67 POTEJ POTEF VCL	1.23e-05	371	43	7	int:ACTA1
Interaction	POTED interactions	POTEB3 POTEC	2.66e-05	4	43	2	int:POTED
Interaction	ADAR interactions	DVL2 POTEE POTEI TRIM67 POTEJ POTEF	3.04e-05	286	43	6	int:ADAR
Interaction	PRTN3 interactions	POTEE BIRC2 LTF FBXO21	4.20e-05	91	43	4	int:PRTN3
Interaction	TRIM33 interactions	DVL2 TOMM70 LTF TRIM67 VCL CDC23 EIF3CL	4.43e-05	453	43	7	int:TRIM33
Interaction	GNPNAT1 interactions	TRIM67 FH VCL	5.65e-05	35	43	3	int:GNPNAT1
Interaction	PDCL3 interactions	CCT4 POTEI TRIM67 POTEF	6.07e-05	100	43	4	int:PDCL3
Interaction	POTEB2 interactions	POTEB3 POTEB2	6.63e-05	6	43	2	int:POTEB2
Interaction	SORBS3 interactions	DVL2 DVL3 TRIM67 VCL CDC23	6.80e-05	202	43	5	int:SORBS3
Interaction	NXN interactions	DVL2 DVL3 TRIM67	7.25e-05	38	43	3	int:NXN
Interaction	RCOR1 interactions	DVL2 DVL3 TPR LTF TRIM67 CDC23 USP24	7.65e-05	494	43	7	int:RCOR1
Interaction	TBL1Y interactions	CCT4 TRIM67 TBL1Y	8.46e-05	40	43	3	int:TBL1Y
Interaction	ACTC1 interactions	TPR POTEE CCT4 POTEI TRIM67 POTEJ POTEF VCL	9.47e-05	694	43	8	int:ACTC1
Interaction	ACTA2 interactions	POTEE CCT4 POTEI TRIM67 POTEJ POTEF	1.01e-04	355	43	6	int:ACTA2
Interaction	FOXK2 interactions	DVL2 DVL3 TPR TRIM67 TBL1Y	1.13e-04	225	43	5	int:FOXK2
Interaction	PDK3 interactions	DVL2 CCT4 TRIM67 MRM1	1.44e-04	125	43	4	int:PDK3
Interaction	SUV39H1 interactions	DVL3 DDI2 CCT4 CDC23 USP24	1.47e-04	238	43	5	int:SUV39H1
Interaction	SNW1 interactions	DVL2 DVL3 TPR WDR18 CCT4 MSL1 TRIM67 CDC23	1.57e-04	747	43	8	int:SNW1
Interaction	OXCT1 interactions	PRSS35 TRIM67 FH MRM1	1.83e-04	133	43	4	int:OXCT1
Interaction	POTEJ interactions	POTEE POTEI POTEJ	1.86e-04	52	43	3	int:POTEJ
Interaction	CXorf38 interactions	TRIM67 POTEF	1.98e-04	10	43	2	int:CXorf38
Interaction	MMP20 interactions	FH MMP20	1.98e-04	10	43	2	int:MMP20
Interaction	TBK1 interactions	TPR BIRC2 TOMM70 TRIM67 VCL USP24	1.98e-04	402	43	6	int:TBK1
Interaction	CLASP1 interactions	CLIP4 TPR TRIM67 VCL	2.11e-04	138	43	4	int:CLASP1
Interaction	AP1S2 interactions	POTEB3 TRIM67 POTEG	2.32e-04	56	43	3	int:AP1S2
Interaction	EIF1B interactions	DVL2 DVL3 POTEI	2.32e-04	56	43	3	int:EIF1B
Interaction	ATPSCKMT interactions	POTEI POTEF	2.42e-04	11	43	2	int:ATPSCKMT
Interaction	AGRN interactions	DVL2 DVL3 TRIM67 CAMKV USP24	2.51e-04	267	43	5	int:AGRN
Interaction	USP9X interactions	DVL2 BIRC2 CCT4 TRIM67 CAMKV USP24	2.57e-04	422	43	6	int:USP9X
Interaction	DIABLO interactions	BIRC2 TOMM70 TRIM67 FH MMP20	2.60e-04	269	43	5	int:DIABLO
Interaction	TPMT interactions	POTEI TRIM67	2.90e-04	12	43	2	int:TPMT
Interaction	AP1G1 interactions	DVL2 POTEB3 TRIM67 POTEG	2.90e-04	150	43	4	int:AP1G1
Interaction	AP3M1 interactions	DVL3 TRIM67 CAMKV VCL	2.90e-04	150	43	4	int:AP3M1
Interaction	TFCP2 interactions	POTEE CCT4 POTEI TRIM67 POTEJ POTEF	3.07e-04	436	43	6	int:TFCP2
Interaction	ULK3 interactions	TPR BIRC2 CCT4	3.13e-04	62	43	3	int:ULK3
Cytoband	2q21.1	POTEE POTEI POTEJ POTEF	3.00e-07	58	44	4	2q21.1
Cytoband	Ensembl 112 genes in cytogenetic band chr2q21	POTEE POTEI POTEJ POTEF	1.38e-05	151	44	4	chr2q21
Cytoband	Ensembl 112 genes in cytogenetic band chr15q11	POTEB3 POTEB2 POTEB	1.20e-03	217	44	3	chr15q11
Cytoband	Ensembl 112 genes in cytogenetic band chr2q36	KCNE4 SPHKAP	3.05e-03	85	44	2	chr2q36
Cytoband	3p21.31	LTF CAMKV	4.19e-03	100	44	2	3p21.31
Cytoband	Ensembl 112 genes in cytogenetic band chr11q22	BIRC2 MMP20	4.78e-03	107	44	2	chr11q22
GeneFamily	Ankyrin repeat domain containing\|POTE ankyrin domain containing	POTEE POTEI POTEJ POTEB2 POTEM POTEH POTEB POTEF POTEC POTEG	2.57e-26	13	33	10	685
GeneFamily	Ankyrin repeat domain containing	CLIP4 POTEE POTEI POTEJ POTEB2 POTEM POTEH POTEB POTEF POTEC POTEG	2.94e-13	242	33	11	403
GeneFamily	Dishevelled segment polarity proteins\|PDZ domain containing	DVL2 DVL3	1.93e-05	4	33	2	505
Coexpression	RAO_BOUND_BY_SALL4_ISOFORM_B	POTEB3 POTEE BIRC2 POTEI POTEJ POTEB2 POTEM POTEH POTEB POTEF POTEC POTEG	1.47e-10	584	44	12	MM1080
Coexpression	DARWICHE_PAPILLOMA_PROGRESSION_RISK	POTEB2 POTEM POTEH POTEB POTEC	4.65e-07	92	44	5	MM503
Coexpression	DESCARTES_ORGANOGENESIS_EPENDYMAL_CELL	POTEB2 POTEM POTEH POTEB POTEC POTEG	7.36e-06	282	44	6	MM3642
Coexpression	KATSANOU_ELAVL1_TARGETS_UP	PRSS35 POTEM POTEH POTEB POTEC	1.56e-05	188	44	5	MM1071
CoexpressionAtlas	prostate	WSCD2 POTEI TBL1Y POTEH POTEG	2.99e-05	179	43	5	prostate
ToppCell	TCGA-Brain-Primary_Tumor-Glioblastoma-Primary_GBM-11\|TCGA-Brain / Sample_Type by Project: Shred V9	POTEE POTEI POTEJ POTEF POTEG EIF3CL	4.00e-11	63	44	6	d7dc1356a60cb527fe668328d5375f352239d911
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-9\|TCGA-Breast / Sample_Type by Project: Shred V9	POTEE POTEI POTEJ POTEM POTEH POTEF	3.59e-10	90	44	6	96e836c7a1df279ac812b7c3aa75e6b81b614244
ToppCell	Smart-seq2-blood_(Smart-seq2)-hematologic-thrombocytic-platelet\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	POTEE POTEI POTEF VCL POTEG	9.28e-07	180	44	5	beb4d777e0c5fa0a59672dbc3dbb7732498605ff
ToppCell	Smart-seq2-blood_(Smart-seq2)-hematologic-thrombocytic\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	POTEE POTEI POTEF VCL POTEG	9.28e-07	180	44	5	fb3d549c2a69b2157a486786ddd775ca16699ed0
ToppCell	TCGA-Prostate\|World / Sample_Type by Project: Shred V9	POTEM TBL1Y POTEH POTEG	6.63e-06	123	44	4	22b38555652b7a426a6277ed385361ae275310a3
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	POTEJ POTEM POTEC POTEG	9.87e-06	136	44	4	88b5c839d0446c6d6b7e81fc4d48f5e7e96eea11
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	POTEJ POTEM POTEC POTEG	9.87e-06	136	44	4	27a41463e6f16deb5b1d4f17fefded9959038c07
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	POTEI POTEJ DACH2 SPHKAP	2.06e-05	164	44	4	be49af6335f2505065cde2cb9800e4a5516811b1
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	POTEI POTEJ DACH2 SPHKAP	2.32e-05	169	44	4	b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Adult / Lineage, Cell type, age group and donor	WDR18 DACH2 MRM1 SPHKAP	2.66e-05	175	44	4	4db1a3c284488b3f6de7568363f176d74e2a4587
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231\|Adult / Lineage, Cell type, age group and donor	WDR18 DACH2 MRM1 SPHKAP	2.66e-05	175	44	4	8d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	POTEI POTEJ DACH2 SPHKAP	3.10e-05	182	44	4	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	TCGA-Brain-Primary_Tumor-Glioblastoma\|TCGA-Brain / Sample_Type by Project: Shred V9	POTEE POTEF EIF3CL	3.65e-05	65	44	3	3592efe68696dd5b806183c8bcd4957c1cd8e045
ToppCell	TCGA-Brain-Primary_Tumor-Glioblastoma-Primary_GBM\|TCGA-Brain / Sample_Type by Project: Shred V9	POTEE POTEF EIF3CL	3.65e-05	65	44	3	c53b6e1e454b7c34cac07b287ffd9e8e64fa79c8
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma-Endometrioid_Adenocarcinoma\|TCGA-Cervix / Sample_Type by Project: Shred V9	POTEM POTEH POTEG	1.13e-04	95	44	3	48ad5d89ee9a1941d1d3dbdbfb03893a390c0d64
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma-Endometrioid_Adenocarcinoma-4\|TCGA-Cervix / Sample_Type by Project: Shred V9	POTEM POTEH POTEG	1.17e-04	96	44	3	4cca2f5e754b82075740adaa0a147d16368be908
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Acinar_Adenocarcinoma-4\|TCGA-Lung / Sample_Type by Project: Shred V9	MUC17 POTEB POTEG	1.44e-04	103	44	3	0cdd2ac33de303ba6883a090f6909582a4c75059
ToppCell	TCGA-Stomach\|World / Sample_Type by Project: Shred V9	POTEE MUC17 EIF3CL	1.61e-04	107	44	3	f35fa6b05aacfd0bd6a8f9d5dbdd4a66212cc3cf
Disease	body mass index, osteoarthritis	WSCD2 CAMKV	1.78e-03	54	34	2	EFO_0004340, MONDO_0005178
Disease	Osteoporosis, Senile	LTF VCL	2.26e-03	61	34	2	C0029459
Disease	Osteoporosis, Age-Related	LTF VCL	2.26e-03	61	34	2	C0001787
Disease	Post-Traumatic Osteoporosis	LTF VCL	2.26e-03	61	34	2	C0751406
Disease	platelet-derived growth factor BB measurement	PRSS35 KCNE4	2.26e-03	61	34	2	EFO_0008264
Disease	Osteoporosis	LTF VCL	2.41e-03	63	34	2	C0029456
Disease	alcoholic pancreatitis	DDI2 DACH2	5.72e-03	98	34	2	EFO_1002013
Disease	pelvic organ prolapse	DVL2 WSCD2	1.07e-02	136	34	2	EFO_0004710
Disease	lung non-small cell carcinoma (is_implicated_in)	LTF FH	1.12e-02	139	34	2	DOID:3908 (is_implicated_in)
Disease	memory performance	PRSS35 KCNE4 FH	1.15e-02	409	34	3	EFO_0004874
Disease	C-reactive protein measurement	WSCD2 KCNE4 CAMKV SPHKAP EIF3CL	1.17e-02	1206	34	5	EFO_0004458
Disease	neurodegenerative disease (implicated_via_orthology)	DVL2 DVL3	1.21e-02	145	34	2	DOID:1289 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MAASTSMVPVAVTAA	CDC23	1	Q9UJX2
AATVAAATMAMPEVK	AHDC1	571	Q5TGY3
VDMPLEMADAAATAK	CLIP4	231	Q8N3C7
DMAAIVKAMASPESG	DVL3	411	Q92997
TPTGITAAAMAEAMK	DACH2	211	Q96NX9
TDMASVTKAMAAPES	DVL2	421	O14641
MVAEVCSMPAASAVK	POTEB2	1	H3BUK9
MAAAAVDSAMEVVPA	FBXO21	1	O94952
MVVEVDSMPAASSVK	POTEF	1	A5A3E0
VSLAPAVEAASMLKM	KCNE4	41	Q8WWG9
MTMRSAVFKAAAAPA	MSL1	1	Q68DK7
NAKSMPADVSEALMS	NDOR1	551	Q9UHB4
MVAEVCSMPAASAVK	POTEB3	1	A0JP26
MVVEVDSMPAASSVK	POTEE	1	Q6S8J3
PESMREHVVAASKAM	EIF3CL	731	B5ME19
MLATKAAATPEPAMA	CAMKV	451	Q8NCB2
KVNPTQCEAMTMVAA	FH	371	P07954
PVKAFVDSGAQMTIM	DDI2	246	Q5TDH0
MVTEVCSMPAASAVK	POTEC	1	B2RU33
PSMSSVEVDKAVEMA	MMP20	131	O60882
AAVDIVMASSVVPKM	OR52I1	71	Q8NGK6
MPASTMKVASSEAIT	MUC17	221	Q685J3
FSMMDKDVPSACAVA	SPHKAP	346	Q2M3C7
AMAPNHAVVSRMDKV	LTF	611	P02788
PVVSKSSAGAMEVMD	MRM1	186	Q6IN84
MVAEVCSMPAASAVK	POTEB	1	A0A0A6YYL3
MVAEVDSMPAASSVK	POTEJ	1	P0CG39
MSVNAVMKVIDPATA	CCT4	186	P50991
MVAEVDSMPAASSVK	POTEI	1	P0CG38
MAAPMEVAVCTDSAA	WDR18	1	Q9BV38
EDAVMMNTPVVKSAL	BIRC2	386	Q13490
PAFGVARASVVKDMM	TRIM67	666	Q6ZTA4
AAMSPTAAAVAKIVK	TPR	376	P12270
TSPAFEADAKMMVNT	PRSS35	46	Q8N3Z0
PMVMDAKAVAGNISD	VCL	796	P18206
MAASKPVEAAVVAAA	TOMM70	1	O94826
SAMAKAATMTPAAIS	TBL1Y	116	Q9BQ87
RMAAPKIAEATFIMA	PLEKHH1	1306	Q9ULM0
ATKMLTATAMPTVAT	USP24	896	Q9UPU5
AGPVAIMKTMDVVFA	SLC35G1	311	Q2M3R5
ALPVTAAMLNMSVDK	WSCD2	246	Q2TBF2
MVAEAGSMPAASSVK	POTEG	1	Q6S5H5
MVAEAGSMPAASSVK	POTEH	1	Q6S545
MVAEAGSMPAASSVK	POTEM	1	A6NI47