Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	toxic substance binding	DSG1 AZU1 CHRNA7 GUCY2C CHRFAM7A	1.89e-08	18	96	5	GO:0015643
GeneOntologyMolecularFunction	ephrin receptor activity	EPHB6 EPHA2 EPHA1	9.87e-05	19	96	3	GO:0005003
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	EPHB6 INSR EPHA2 EPHA1	2.71e-04	65	96	4	GO:0004714
GeneOntologyMolecularFunction	extracellular matrix structural constituent	COL6A1 LAMA5 FBN2 ACAN MUC2 FBN3	2.95e-04	188	96	6	GO:0005201
GeneOntologyBiologicalProcess	positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure	CHRNA7 CHRFAM7A	2.10e-05	2	95	2	GO:0001988
GeneOntologyBiologicalProcess	homocysteine metabolic process	COMT MTHFR MTR	4.14e-05	15	95	3	GO:0050667
GeneOntologyBiologicalProcess	baroreceptor response to decreased systemic arterial blood pressure	CHRNA7 CHRFAM7A	6.28e-05	3	95	2	GO:0001982
GeneOntologyCellularComponent	spine apparatus membrane	CHRNA7 CHRFAM7A	6.24e-05	3	96	2	GO:0098897
MousePheno	airway basal cell hyperplasia	CHRNA7 CHRFAM7A	2.99e-05	2	77	2	MP:0011115
MousePheno	abnormal airway basal cell differentiation	CHRNA7 CHRFAM7A	2.99e-05	2	77	2	MP:0011114
MousePheno	abnormal airway basal cell morphology	CHRNA7 CHRFAM7A	2.99e-05	2	77	2	MP:0011113
Domain	Growth_fac_rcpt_	EPHB6 INSR LAMA5 SVEP1 FBN2 EPHA2 FBN3 NOTCH3 EPHA1	7.55e-08	156	92	9	IPR009030
Domain	Ephrin_rec_like	EPHB6 SVEP1 TNFRSF11B EPHA2 EPHA1	1.28e-07	25	92	5	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHB6 SVEP1 TNFRSF11B EPHA2 EPHA1	1.28e-07	25	92	5	IPR011641
Domain	Galactose-bd-like	EPHB6 MANBA MYCBP2 LAMA5 PTPRU EPHA2 EPHA1	4.03e-07	94	92	7	IPR008979
Domain	EGF-like_CS	ZAN LAMA5 SVEP1 FBN2 TENM4 EPHA2 TENM1 FBN3 NOTCH3 EPHA1	6.30e-07	261	92	10	IPR013032
Domain	EGF_2	ZAN LAMA5 SVEP1 FBN2 TENM4 EPHA2 TENM1 FBN3 NOTCH3 EPHA1	7.24e-07	265	92	10	PS01186
Domain	FN3	EPHB6 FLNC INSR PTPRU PTPRG EPHA2 TRIM36 EPHA1	3.65e-06	185	92	8	SM00060
Domain	FN3_dom	EPHB6 FLNC INSR PTPRU PTPRG EPHA2 TRIM36 EPHA1	8.95e-06	209	92	8	IPR003961
Domain	hEGF	SVEP1 FBN2 FBN3 NOTCH3	1.03e-05	28	92	4	PF12661
Domain	fn3	EPHB6 INSR PTPRU PTPRG EPHA2 TRIM36 EPHA1	1.53e-05	162	92	7	PF00041
Domain	EGF	ZAN LAMA5 SVEP1 FBN2 TENM4 TENM1 FBN3 NOTCH3	2.09e-05	235	92	8	SM00181
Domain	-	EPHB6 MANBA MYCBP2 EPHA2 EPHA1	3.00e-05	73	92	5	2.60.120.260
Domain	EGF-like_dom	ZAN LAMA5 SVEP1 FBN2 TENM4 TENM1 FBN3 NOTCH3	3.16e-05	249	92	8	IPR000742
Domain	EGF_1	ZAN LAMA5 SVEP1 FBN2 TENM4 TENM1 FBN3 NOTCH3	3.75e-05	255	92	8	PS00022
Domain	RECEPTOR_TYR_KIN_V_2	EPHB6 EPHA2 EPHA1	4.05e-05	14	92	3	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHB6 EPHA2 EPHA1	4.05e-05	14	92	3	PS00790
Domain	Tyr_kinase_rcpt_V_CS	EPHB6 EPHA2 EPHA1	4.05e-05	14	92	3	IPR001426
Domain	EphA2_TM	EPHB6 EPHA2 EPHA1	4.05e-05	14	92	3	PF14575
Domain	Ephrin_rcpt_lig-bd_dom	EPHB6 EPHA2 EPHA1	4.05e-05	14	92	3	IPR001090
Domain	Eph_TM	EPHB6 EPHA2 EPHA1	4.05e-05	14	92	3	IPR027936
Domain	EPH_lbd	EPHB6 EPHA2 EPHA1	4.05e-05	14	92	3	SM00615
Domain	Ephrin_lbd	EPHB6 EPHA2 EPHA1	4.05e-05	14	92	3	PF01404
Domain	Tyr_kinase_ephrin_rcpt	EPHB6 EPHA2 EPHA1	4.05e-05	14	92	3	IPR016257
Domain	EPH_LBD	EPHB6 EPHA2 EPHA1	4.05e-05	14	92	3	PS51550
Domain	FN3	EPHB6 INSR PTPRU PTPRG EPHA2 TRIM36 EPHA1	5.72e-05	199	92	7	PS50853
Domain	FBN	FBN2 FBN3	7.18e-05	3	92	2	IPR011398
Domain	Tox-GHH_dom	TENM4 TENM1	1.43e-04	4	92	2	IPR028916
Domain	Tox-GHH	TENM4 TENM1	1.43e-04	4	92	2	PF15636
Domain	Ten_N	TENM4 TENM1	1.43e-04	4	92	2	IPR009471
Domain	Ten_N	TENM4 TENM1	1.43e-04	4	92	2	PF06484
Domain	TENEURIN_N	TENM4 TENM1	1.43e-04	4	92	2	PS51361
Domain	EGF_3	ZAN SVEP1 FBN2 TENM4 TENM1 FBN3 NOTCH3	1.61e-04	235	92	7	PS50026
Domain	EGF_extracell	SVEP1 TENM4 TENM1 NOTCH3	2.18e-04	60	92	4	IPR013111
Domain	EGF_2	SVEP1 TENM4 TENM1 NOTCH3	2.18e-04	60	92	4	PF07974
Domain	YD	TENM4 TENM1	2.38e-04	5	92	2	IPR006530
Domain	MSP_dom	MOSPD2 CFAP65	3.55e-04	6	92	2	IPR000535
Domain	MSP	MOSPD2 CFAP65	3.55e-04	6	92	2	PS50202
Domain	-	EPHB6 FLNC MYCBP2 INSR SEMA3G PTPRU PTPRG EPHA2 ALPK3 TRIM36 EPHA1	4.10e-04	663	92	11	2.60.40.10
Domain	Pkinase_Tyr	EPHB6 INSR GUCY2C EPHA2 EPHA1	4.42e-04	129	92	5	PF07714
Domain	TB	FBN2 FBN3	4.96e-04	7	92	2	PF00683
Domain	Ser-Thr/Tyr_kinase_cat_dom	EPHB6 INSR GUCY2C EPHA2 EPHA1	6.02e-04	138	92	5	IPR001245
Domain	-	FBN2 FBN3	6.59e-04	8	92	2	3.90.290.10
Domain	Ig-like_fold	EPHB6 FLNC MYCBP2 INSR SEMA3G PTPRU PTPRG EPHA2 ALPK3 TRIM36 EPHA1	6.92e-04	706	92	11	IPR013783
Domain	VWFC_1	AMN ZAN MUC2	7.34e-04	36	92	3	PS01208
Domain	ConA-like_dom	TRIM15 ZAN LAMA5 PTPRU SVEP1 TRIM36	7.48e-04	219	92	6	IPR013320
Domain	PapD-like	MOSPD2 CFAP65	8.45e-04	9	92	2	IPR008962
Domain	TB_dom	FBN2 FBN3	8.45e-04	9	92	2	IPR017878
Domain	TB	FBN2 FBN3	8.45e-04	9	92	2	PS51364
Domain	EGF_CA	SVEP1 FBN2 FBN3 NOTCH3	8.60e-04	86	92	4	PF07645
Domain	VWFC_2	AMN ZAN MUC2	8.61e-04	38	92	3	PS50184
Domain	VWF_dom	AMN ZAN MUC2	1.16e-03	42	92	3	IPR001007
Domain	Filamin	FLNC MYCBP2	1.28e-03	11	92	2	PF00630
Domain	Ephrin_rec_like	EPHB6 SVEP1	1.28e-03	11	92	2	PF07699
Domain	FILAMIN_REPEAT	FLNC MYCBP2	1.28e-03	11	92	2	PS50194
Domain	Filamin/ABP280_rpt	FLNC MYCBP2	1.28e-03	11	92	2	IPR001298
Domain	Filamin/ABP280_repeat-like	FLNC MYCBP2	1.28e-03	11	92	2	IPR017868
Domain	-	STRN3 WDR46 SEMA3G TEP1 WDR59 DNAI1 PAK1IP1	1.29e-03	333	92	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	STRN3 WDR46 SEMA3G TEP1 WDR59 DNAI1 PAK1IP1	1.33e-03	335	92	7	IPR015943
Domain	EGF_Ca-bd_CS	SVEP1 FBN2 FBN3 NOTCH3	1.35e-03	97	92	4	IPR018097
Domain	EGF_CA	SVEP1 FBN2 FBN3 NOTCH3	1.45e-03	99	92	4	PS01187
Domain	ASX_HYDROXYL	SVEP1 FBN2 FBN3 NOTCH3	1.51e-03	100	92	4	PS00010
Domain	C8	ZAN MUC2	1.53e-03	12	92	2	PF08742
Domain	TIL	ZAN MUC2	1.53e-03	12	92	2	PF01826
Domain	WD40	STRN3 WDR46 TEP1 WDR59 DNAI1 PAK1IP1	1.77e-03	259	92	6	PF00400
Domain	OTU	OTUD7B VCPIP1	1.81e-03	13	92	2	PF02338
Domain	Unchr_dom_Cys-rich	ZAN MUC2	1.81e-03	13	92	2	IPR014853
Domain	C8	ZAN MUC2	1.81e-03	13	92	2	SM00832
Domain	NHL	TENM4 TENM1	1.81e-03	13	92	2	PS51125
Domain	EGF-type_Asp/Asn_hydroxyl_site	SVEP1 FBN2 FBN3 NOTCH3	1.87e-03	106	92	4	IPR000152
Domain	WD40	STRN3 WDR46 TEP1 WDR59 DNAI1 PAK1IP1	2.10e-03	268	92	6	SM00320
Domain	TIL_dom	ZAN MUC2	2.10e-03	14	92	2	IPR002919
Domain	WD40_repeat	STRN3 WDR46 TEP1 WDR59 DNAI1 PAK1IP1	2.26e-03	272	92	6	IPR001680
Domain	OTU	OTUD7B VCPIP1	2.42e-03	15	92	2	PS50802
Domain	OTU_dom	OTUD7B VCPIP1	2.42e-03	15	92	2	IPR003323
Domain	WD_REPEATS_1	STRN3 WDR46 TEP1 WDR59 DNAI1 PAK1IP1	2.52e-03	278	92	6	PS00678
Domain	WD_REPEATS_2	STRN3 WDR46 TEP1 WDR59 DNAI1 PAK1IP1	2.57e-03	279	92	6	PS50082
Domain	WD_REPEATS_REGION	STRN3 WDR46 TEP1 WDR59 DNAI1 PAK1IP1	2.57e-03	279	92	6	PS50294
Domain	VWF_type-D	ZAN MUC2	2.75e-03	16	92	2	IPR001846
Domain	MAM_1	ZAN PTPRU	2.75e-03	16	92	2	PS00740
Domain	VWFD	ZAN MUC2	2.75e-03	16	92	2	PS51233
Domain	VWD	ZAN MUC2	2.75e-03	16	92	2	SM00216
Domain	VWD	ZAN MUC2	2.75e-03	16	92	2	PF00094
Domain	PTPc_motif	DUSP4 PTPRU PTPRG	3.08e-03	59	92	3	SM00404
Domain	Tyr_Pase_cat	DUSP4 PTPRU PTPRG	3.08e-03	59	92	3	IPR003595
Domain	EGF_CA	SVEP1 FBN2 FBN3 NOTCH3	3.11e-03	122	92	4	SM00179
Domain	MAM	ZAN PTPRU	3.11e-03	17	92	2	SM00137
Domain	EGF-like_Ca-bd_dom	SVEP1 FBN2 FBN3 NOTCH3	3.30e-03	124	92	4	IPR001881
Domain	MAM	ZAN PTPRU	3.49e-03	18	92	2	PF00629
Domain	MAM_dom	ZAN PTPRU	3.49e-03	18	92	2	IPR000998
Domain	MAM_2	ZAN PTPRU	3.49e-03	18	92	2	PS50060
Domain	EGF	ZAN SVEP1 FBN3 NOTCH3	3.49e-03	126	92	4	PF00008
Domain	WD40_repeat_dom	STRN3 WDR46 TEP1 WDR59 DNAI1 PAK1IP1	3.49e-03	297	92	6	IPR017986
Domain	VWC_out	ZAN MUC2	3.89e-03	19	92	2	SM00215
Pathway	REACTOME_COBALAMIN_CBL_VITAMIN_B12_TRANSPORT_AND_METABOLISM	AMN CTRB2 MTR CTRB1	4.27e-06	22	72	4	M27084
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	COL6A1 CTRB2 LAMA5 FBN2 ACAN CTRB1 FBN3	7.05e-06	140	72	7	M587
Pathway	WP_FOLATEALCOHOL_AND_CANCER_PATHWAY_HYPOTHESES	ADH5 MTHFR MTR	1.05e-05	9	72	3	M39396
Pathway	REACTOME_UPTAKE_OF_DIETARY_COBALAMINS_INTO_ENTEROCYTES	AMN CTRB2 CTRB1	1.49e-05	10	72	3	M45024
Pathway	WP_FOLIC_ACID_NETWORK	XDH MTHFR MTR	1.83e-04	22	72	3	MM15955
Pathway	WP_SELENIUM_MICRONUTRIENT_NETWORK	XDH MTHFR MTR	2.10e-04	23	72	3	MM15979
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	COL6A1 CTRB2 FBN2 ACAN CTRB1	2.88e-04	114	72	5	MM14571
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FLNC MYCBP2 MYO9B SIPA1L3 PER1 LAMA5 TEP1 WDR59 HIVEP3 EHBP1L1 MTHFR TTLL4 SEC16A CENPV PLCG1 DHX34	9.23e-08	1105	99	16	35748872
Pubmed	Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina.	GSTT1 MTHFR MTR	4.45e-07	6	99	3	17450230
Pubmed	[The association of TCR-mutant cells with DNA polymorphism in women residing in radiation polluted regions of the Russian Federation].	COMT GSTT1 MTHFR	7.77e-07	7	99	3	19799358
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	LAMA5 FBN2 ACAN NOTCH3	8.80e-07	26	99	4	34189436
Pubmed	Variable drug metabolism genes in Arab population.	GSTT1 MTHFR MTR	1.24e-06	8	99	3	15111988
Pubmed	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	COMT XDH ADH5 MTHFR EPHA2	1.31e-06	66	99	5	19898482
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	EPHB6 COL6A1 MYCBP2 MYO9B SEMA3G PTPRU FBN2 MTHFR TONSL MARF1 TENM1 NEURL1B DHX34 FBN3 EPHA1	1.78e-06	1215	99	15	15146197
Pubmed	Genotype frequencies of 50 polymorphisms for 241 Japanese non-cancer patients.	COMT SRD5A2 MTHFR MTR	3.39e-06	36	99	4	12164325
Pubmed	Pharmacogenetic analyses of a phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil and leucovorin plus either oxaliplatin or cisplatin: a study of the arbeitsgemeinschaft internistische onkologie.	GSTT1 MTHFR MTR	3.63e-06	11	99	3	19332728
Pubmed	Oxidative damage to biological macromolecules in Prague bus drivers and garagemen: impact of air pollution and genetic polymorphisms.	GSTT1 MTHFR MTR	3.63e-06	11	99	3	20723587
Pubmed	Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.	EPHB6 INSR EPHA2 EPHA1	5.22e-06	40	99	4	30898150
Pubmed	Pharmacogenomic variations in treatment protocols for childhood acute lymphoblastic leukemia.	GSTT1 MTHFR MTR	6.27e-06	13	99	3	19774638
Pubmed	A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.	EPHB6 PTPRU TENM4 TENM1 EPHA1	6.47e-06	91	99	5	28558017
Pubmed	Chromosomal aberrations in railroad transit workers: effect of genetic polymorphisms.	GSTT1 MTHFR MTR	7.96e-06	14	99	3	19177501
Pubmed	Enhancing cognitive function in chronic TBI: The Role of α7 nicotinic acetylcholine receptor modulation.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	38070724
Pubmed	COMT and MTHFR polymorphisms interaction on cognition in schizophrenia: an exploratory study.	COMT MTHFR	8.02e-06	2	99	2	23353103
Pubmed	Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	34453977
Pubmed	Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	26999808
Pubmed	Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	27129924
Pubmed	Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	23521765
Pubmed	Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	28258105
Pubmed	The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	19344760
Pubmed	Methylenetetrahydrofolate reductase and methionine synthase polymorphisms and risk of bladder cancer in a Tunisian population.	MTHFR MTR	8.02e-06	2	99	2	17574963
Pubmed	Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	29114104
Pubmed	Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	33995108
Pubmed	E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	32552811
Pubmed	Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	24836856
Pubmed	Association analysis of COMT/MTHFR polymorphisms and major depressive disorder in Chinese Han population.	COMT MTHFR	8.02e-06	2	99	2	24751310
Pubmed	Comorbidity of 5,10-methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms and risk for neural tube defects.	MTHFR MTR	8.02e-06	2	99	2	11186937
Pubmed	ANALYSIS OF RELATIONSHIP BETWEEN POLYMORPHISM OF MTHFR (C677T), MTHFR (A1298C), MTR (A2756G) GENES IN THE DEVELOPMENT OF ISCHEMIC STROKE IN YOUNG PATIENTS.	MTHFR MTR	8.02e-06	2	99	2	34749329
Pubmed	Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	15948184
Pubmed	Methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms and reduced risk of malignant lymphoma.	MTHFR MTR	8.02e-06	2	99	2	15551285
Pubmed	Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	35678315
Pubmed	The CTRB1-CTRB2 risk allele for chronic pancreatitis discovered in European populations does not contribute to disease risk variation in the Chinese population due to near allele fixation.	CTRB2 CTRB1	8.02e-06	2	99	2	28951524
Pubmed	Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	12628457
Pubmed	MTHFR C677T, MTHFR A1298C, and OPG A163G polymorphisms in Mexican patients with rheumatoid arthritis and osteoporosis.	TNFRSF11B MTHFR	8.02e-06	2	99	2	22377704
Pubmed	Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	25157794
Pubmed	Mesenchymal Stem Cells or Interleukin-6 Improve Episodic Memory of Mice Lacking α7 Nicotinic Acetylcholine Receptors.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	31202708
Pubmed	Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	22246862
Pubmed	Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.	CTRB2 CTRB1	8.02e-06	2	99	2	28754779
Pubmed	Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	27471776
Pubmed	Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	22688057
Pubmed	Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	32028688
Pubmed	Interactive effects of COMT Val108/158Met and MTHFR C677T on executive function in schizophrenia.	COMT MTHFR	8.02e-06	2	99	2	18186041
Pubmed	Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	30429582
Pubmed	A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	21501254
Pubmed	Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	21368056
Pubmed	Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	1400473
Pubmed	Study of MTHFR and MS polymorphisms as risk factors for NTD in the Italian population.	MTHFR MTR	8.02e-06	2	99	2	12111380
Pubmed	Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan.	MTHFR MTR	8.02e-06	2	99	2	19838916
Pubmed	Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	26937017
Pubmed	Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	36603528
Pubmed	Activation of α7nAChR Promotes Diabetic Wound Healing by Suppressing AGE-Induced TNF-α Production.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	26650489
Pubmed	Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	22848433
Pubmed	Osteoprotegerin and MTHFR gene variations in rheumatoid arthritis: association with disease susceptibility and markers of subclinical atherosclerosis.	TNFRSF11B MTHFR	8.02e-06	2	99	2	35680906
Pubmed	Localization of folate metabolic enzymes, methionine synthase and 5,10-methylenetetrahydrofolate reductase in human placenta.	MTHFR MTR	8.02e-06	2	99	2	25277375
Pubmed	Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma.	MTHFR MTR	8.02e-06	2	99	2	11342450
Pubmed	Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women.	MTHFR MTR	8.02e-06	2	99	2	19389261
Pubmed	Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	16650968
Pubmed	Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	35413868
Pubmed	Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	24462939
Pubmed	Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	29261717
Pubmed	Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	18199426
Pubmed	Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	22490926
Pubmed	MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC Study.	MTHFR MTR	8.02e-06	2	99	2	23595572
Pubmed	Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	23270857
Pubmed	Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	18077004
Pubmed	Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	19462340
Pubmed	Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	16923147
Pubmed	NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	11790782
Pubmed	EphB6 promotes anoikis by modulating EphA2 signaling.	EPHB6 EPHA2	8.02e-06	2	99	2	25239188
Pubmed	Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis.	COMT MTHFR	8.02e-06	2	99	2	16564429
Pubmed	Variants in maternal COMT and MTHFR genes and risk of neural tube defects in offspring.	COMT MTHFR	8.02e-06	2	99	2	24990354
Pubmed	Polymorphisms of methylenetetrahydrofolate reductase and methionine synthase genes and bladder cancer risk: a case-control study with meta-analysis.	MTHFR MTR	8.02e-06	2	99	2	18815869
Pubmed	Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	37746145
Pubmed	A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	19631623
Pubmed	Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	15770102
Pubmed	Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: implications for neuropsychiatric diseases.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	24326163
Pubmed	Genetic polymorphisms involved in folate metabolism and concentrations of methylmalonic acid and folate on plasma homocysteine and risk of coronary artery disease.	MTHFR MTR	8.02e-06	2	99	2	19283448
Pubmed	Functional role of alpha7 nicotinic receptor in chronic neuropathic and inflammatory pain: studies in transgenic mice.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	23811428
Pubmed	Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	20720594
Pubmed	Methionine synthase A2756G and methylenetetrahydrofolate reductase A1298C polymorphisms are not risk factors for idiopathic venous thromboembolism.	MTHFR MTR	8.02e-06	2	99	2	11920232
Pubmed	MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-Analysis.	MTHFR MTR	8.02e-06	2	99	2	28081209
Pubmed	Association analysis of the COMT/MTHFR genes and geriatric depression: an MRI study of the putamen.	COMT MTHFR	8.02e-06	2	99	2	19235787
Pubmed	Ex vivo study for the assessment of behavioral factor and gene polymorphisms in individual susceptibility to oxidative DNA damage metals-induced.	GSTT1 MTHFR	8.02e-06	2	99	2	21334974
Pubmed	Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	17019565
Pubmed	Dilinoleoylphosphatidylcholine ameliorates scopolamine-induced impairment of spatial learning and memory by targeting alpha7 nicotinic ACh receptors.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	19100751
Pubmed	Activation of the α7 Nicotinic Acetylcholine Receptor Prevents against Microglial-Induced Inflammation and Insulin Resistance in Hypothalamic Neuronal Cells.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	35883638
Pubmed	Chrna7 genotype is linked with alpha7 nicotinic receptor expression but not alpha7 RNA levels.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	19368846
Pubmed	Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	15009674
Pubmed	Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA.	CTRB2 CTRB1	8.02e-06	2	99	2	2917002
Pubmed	Hydroxynorketamine, but not ketamine, acts via α7 nicotinic acetylcholine receptor to control presynaptic function and gene expression.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	38253622
Pubmed	Genomic cloning and partial characterization of human chymotrypsinogen gene.	CTRB2 CTRB1	8.02e-06	2	99	2	8186414
Pubmed	The role of dorsal root ganglia alpha-7 nicotinic acetylcholine receptor in complete Freund's adjuvant-induced chronic inflammatory pain.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	34514543
Pubmed	α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	22183893
Pubmed	Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	9364063
Pubmed	Dietary folate, one-carbon metabolism-related genes, and gastric cancer risk in Korea.	MTHFR MTR	8.02e-06	2	99	2	26833750
Pubmed	Evidence suggesting that the mouse sperm acrosome reaction initiated by the zona pellucida involves an alpha7 nicotinic acetylcholine receptor.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	12606407
Pubmed	Genetic variations in CHRNA7 or CHRFAM7 and susceptibility to dementia.	CHRNA7 CHRFAM7A	8.02e-06	2	99	2	22300029
Pubmed	Colorectal cancer and the methylenetetrahydrofolate reductase 677C -> T and methionine synthase 2756A -> G polymorphisms: a study of 2,168 case-control pairs from the JANUS cohort.	MTHFR MTR	8.02e-06	2	99	2	15598777
Interaction	IGFL3 interactions	COL6A1 MANBA MYCBP2 INSR LAMA5 FBN2 NOTCH3	5.87e-08	75	94	7	int:IGFL3
Interaction	FBXO2 interactions	COL6A1 HK2 MANBA AZU1 INSR LAMA5 PTPRU FBN2 PTPRG NOTCH3 EPHA1	3.36e-06	411	94	11	int:FBXO2
Interaction	PTPN12 interactions	FLNC MYCBP2 DUSP4 INSR EHBP1L1 TENM1 PLCG1	5.24e-06	145	94	7	int:PTPN12
Interaction	F12 interactions	PER1 TEP1 UBE2N MTR VCPIP1	3.01e-05	77	94	5	int:F12
Interaction	PRG2 interactions	COL6A1 B4GALNT1 MANBA LAMA5 PTPRU FBN2 MAPK4 NOTCH3	5.64e-05	285	94	8	int:PRG2
Interaction	SLURP1 interactions	COL6A1 MANBA INSR GAS1 LAMA5 EPHA1	5.82e-05	144	94	6	int:SLURP1
Interaction	CTRB2 interactions	CTRB2 CTRB1	6.44e-05	3	94	2	int:CTRB2
Interaction	C1QB interactions	MANBA MYCBP2 INSR LAMA5 PTPRU	7.84e-05	94	94	5	int:C1QB
Cytoband	16q23.1	CTRB2 WDR59 CTRB1	4.75e-05	32	100	3	16q23.1
Cytoband	8q24	AGO2 TNFRSF11B	1.71e-03	28	100	2	8q24
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	MYO9B AZU1 INSR ZNF861P PGLS FBN3 NOTCH3	1.84e-03	797	100	7	chr19p13
Cytoband	5q31	PCDHB8 PCDHA7 PCDHB18P	2.07e-03	115	100	3	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr16q23	CTRB2 WDR59 CTRB1	2.13e-03	116	100	3	chr16q23
GeneFamily	Fibronectin type III domain containing	EPHB6 INSR PTPRU PTPRG EPHA2 TRIM36 EPHA1	1.36e-06	160	63	7	555
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHB6 EPHA2 EPHA1	1.43e-05	14	63	3	1095
GeneFamily	WD repeat domain containing	STRN3 WDR46 TEP1 WDR59 DNAI1 PAK1IP1	2.98e-04	262	63	6	362
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CSMD2 SVEP1 ACAN	1.03e-03	57	63	3	1179
GeneFamily	Clustered protocadherins	PCDHB8 PCDHA7 PCDHB18P	1.44e-03	64	63	3	20
GeneFamily	OTU domain containing	OTUD7B VCPIP1	1.57e-03	17	63	2	669
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRU PTPRG	2.40e-03	21	63	2	813
GeneFamily	Sterile alpha motif domain containing	EPHB6 EPHA2 EPHA1	3.58e-03	88	63	3	760
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	SSC4D LY75	3.97e-03	27	63	2	1253
CoexpressionAtlas	Mesoderm Day 5-reprogram_OSKM-L_vs_Mesoderm Day 5-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	COL6A1 FLNC LAMA5 GSTT1 FBN2 TONSL FBN3 NOTCH3	3.83e-05	281	95	8	PCBC_ratio_MESO-5_from-OSKM-L_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-method_mRNA_vs_Mesoderm Day 5-method_NA-Confounder_removed-fold2.0_adjp0.05	COL6A1 FLNC LAMA5 GSTT1 FBN2 TONSL FBN3 NOTCH3	3.83e-05	281	95	8	PCBC_ratio_MESO-5_from-mRNA_vs_MESO-5_from-ESC_cfr-2X-p05
ToppCell	Frontal_cortex-Neuronal-Excitatory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	EPHB6 CACNA1E MYCBP2 CSMD2 GRM8 CFAP65	3.74e-06	184	100	6	6e17c8151d6dc543de16d804db956c63c3fda414
ToppCell	facs-Lung-EPCAM-18m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A1 B4GALNT1 GAS1 SVEP1 RASSF5 GSTT1	4.92e-06	193	100	6	b9ac74357435f2f24aaede62b2a1d31b5d96a12c
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_10\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	B4GALNT1 ZAN DUSP4 TNFRSF11B LY75 CHRFAM7A	4.92e-06	193	100	6	7426a30ed01e5c8376b3e0ebe0f1057cfee88340
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_10\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	B4GALNT1 ZAN DUSP4 TNFRSF11B LY75 CHRFAM7A	4.92e-06	193	100	6	a2194012dfa0174c6160900625c44e0fd04c50e7
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPHB6 COL6A1 FLNC GAS1 SVEP1 TNFRSF11B	5.06e-06	194	100	6	421344cc4b601d9745fa72d0af3124dab11d1d27
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A1 FLNC NIBAN1 EHBP1L1 NEURL1B NOTCH3	5.69e-06	198	100	6	bd42c03e384e64f61b02618cf1a5440033bb04b2
ToppCell	Biopsy_Control_(H.)-Mesenchymal-Mesothelial_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	EPHB6 COL6A1 FLNC GAS1 SVEP1 TNFRSF11B	5.86e-06	199	100	6	ca970114b5aef4518ce580897a62ac88688b2671
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A1 FLNC NIBAN1 EHBP1L1 NEURL1B NOTCH3	5.86e-06	199	100	6	b1753474152b82a0b811b9878c890a359e14919a
ToppCell	Biopsy_IPF-Mesenchymal-Mesothelial_cells\|Biopsy_IPF / Sample group, Lineage and Cell type	EPHB6 COL6A1 FLNC GAS1 SVEP1 TNFRSF11B	6.03e-06	200	100	6	553386523fd8f8f36617a0d81032224b7ddce442
ToppCell	Control-Plasmablast\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NIBAN1 LAMA5 SEMA3G PTPRG MUC2	1.91e-05	145	100	5	fe68582f5a15b9714cb84fa32ac880e13cb69895
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-plasmacytoid_dendritic_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E GRM8 HIVEP3 EPHA2 NOTCH3	2.80e-05	157	100	5	fc127e7720649e746f3d3f5c2e9e63784767106a
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-plasmacytoid_dendritic_cells\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E GRM8 HIVEP3 EPHA2 NOTCH3	2.80e-05	157	100	5	66a191cef4aa00811bb04462310d012610006f85
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Fibroblasts-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTPRU SVEP1 TNFRSF11B HIVEP3 DHX34	2.88e-05	158	100	5	7f5426585d0d299d2b48e5fcb349950feffdef33
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular-6\|TCGA-Stomach / Sample_Type by Project: Shred V9	TRIM15 HK2 SIPA1L3 EPHA2 SEC16A	2.97e-05	159	100	5	655c0749c238bd68cb797adb83e25a23b8a3cc9d
ToppCell	BAL-Mild-cDC_5\|Mild / Compartment, Disease Groups and Clusters	INSR PER1 UNC5CL EPHA2 DHX34	3.16e-05	161	100	5	7a6e8ed0b5d999efce8945d8083ab01d71be9a92
ToppCell	356C-Myeloid-Dendritic-cDC_activated\|356C / Donor, Lineage, Cell class and subclass (all cells)	B4GALNT1 DUSP4 CHRNA7 TNFRSF11B ALPK3	3.76e-05	167	100	5	43a9375fdbafd7450c553e4620e21537e08639dd
ToppCell	facs-Heart-LV-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A1 GAS1 TENM4 PPP1R37 DSCC1	3.98e-05	169	100	5	849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SVEP1 HIVEP3 FBN2 TENM4 ZSCAN22	4.09e-05	170	100	5	ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DUSP4 TNFRSF11B NEURL1B TRIM36 NOTCH3	4.70e-05	175	100	5	2a53d4f140d5ab096efe8118d8aa351db7838b49
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DUSP4 TNFRSF11B NEURL1B TRIM36 NOTCH3	4.70e-05	175	100	5	fb91a45763e4c48d993094a13088ffc19f1e2574
ToppCell	droplet-Kidney-nan-21m-Lymphocytic-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B4GALNT1 MYCBP2 HIVEP3 TONSL CTRB1	4.82e-05	176	100	5	feafc757e7aa4f17128ff34886beb2fd3461c9ea
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A1 GAS1 SVEP1 TENM4 DSCC1	4.82e-05	176	100	5	fee4e0f32aaf77294040c7af6c1f503571750d43
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A1 GAS1 SVEP1 TENM4 DSCC1	4.82e-05	176	100	5	f25251abd4ef9fb077a978f9f9f658af58e4e0d2
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A1 SSC4D TENM1 MAPK4 CHRFAM7A	4.96e-05	177	100	5	c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCell	RV-11._Adipocyte\|RV / Chamber and Cluster_Paper	HK2 MYCBP2 DUSP4 SVEP1 TENM4	5.09e-05	178	100	5	278bbea5cf8f0589f71675c7a3d00679391b5253
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|356C / Donor, Lineage, Cell class and subclass (all cells)	NIBAN1 DUSP4 TONSL PLCG1 VCPIP1	5.09e-05	178	100	5	8b939659f713eea50a1a6e28b571f680ca0b4c12
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NIBAN1 CSMD2 GRM8 HIVEP3 TENM4	5.09e-05	178	100	5	a0ab20c588e7d43d0320d4779d9ab95c1c86e297
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	B4GALNT1 DUSP4 SVEP1 LY75 CHRFAM7A	5.37e-05	180	100	5	32d871738a24071b70084a7e80148a516110c78b
ToppCell	facs-Marrow-B-cells-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E GRM8 HIVEP3 TENM4 EPHA2	5.37e-05	180	100	5	bf8d13d4db1af55b8c9fe16aaccf8743e000e005
ToppCell	facs-Marrow-B-cells-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E GRM8 HIVEP3 TENM4 EPHA2	5.37e-05	180	100	5	839defb40f7cfb2711e9025194de636533f51bcd
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SVEP1 CHRNA7 FBN2 TRIM36 CHRFAM7A	5.37e-05	180	100	5	392bc71a69653ba12de31bed4e9357f181094641
ToppCell	facs-Marrow-B-cells-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E GRM8 HIVEP3 TENM4 EPHA2	5.37e-05	180	100	5	82965ed1b72a1873c24dd4553d39681596057316
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	B4GALNT1 DUSP4 SVEP1 LY75 CHRFAM7A	5.37e-05	180	100	5	067ca8a15228c7f3b3bc7aecbc9b1611ca05e176
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(other)\|COVID-19 / group, cell type (main and fine annotations)	LAMA5 SEMA3G PTPRG SLCO2A1 NEURL1B	5.51e-05	181	100	5	26eb4ee57a70dbf54e096b73129fda9dfda1f6ec
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SVEP1 CHRNA7 FBN2 TRIM36 CHRFAM7A	5.51e-05	181	100	5	03a303cd2f366f09c18b118bbba6f5e3f95ad56c
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SVEP1 CHRNA7 FBN2 TRIM36 CHRFAM7A	5.51e-05	181	100	5	8fd64404e57c22c204d835fc5626f73554257b19
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	COL6A1 SVEP1 TENM4 PTPRG NEURL1B	5.66e-05	182	100	5	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	Pericytes-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	COL6A1 GAS1 ACAN NEURL1B NOTCH3	5.80e-05	183	100	5	4617b18da8d699a44e4c47980197b1e7eb951470
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B CACNA1E COL6A1 AMN DUSP4	5.96e-05	184	100	5	42cadfdb5d29a50bd7e901ddd14d42b39e8474f0
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FLNC NIBAN1 FBN2 ALPK3 MAPK4	5.96e-05	184	100	5	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A1 CSMD2 SVEP1 TENM1 CHRFAM7A	6.11e-05	185	100	5	9faa35ceb89ccd2979072286f063687c9f846ce3
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FLNC NIBAN1 FBN2 ALPK3 MAPK4	6.11e-05	185	100	5	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1E B4GALNT1 DUSP4 TMEM271 TRIM36	6.27e-05	186	100	5	18fd311252299d6d30ddb32002ed069056108206
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	DENND5B SIPA1L3 ZNF213 SSC4D PTPRG	6.27e-05	186	100	5	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	EPHB6 COL6A1 FLNC GAS1 SVEP1	6.27e-05	186	100	5	7812ed80d2378aca9957ef22fc3c8fb7fb58434b
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NIBAN1 CSMD2 TNFRSF11B ACAN NOTCH3	6.27e-05	186	100	5	4780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	DENND5B SIPA1L3 ZNF213 SSC4D PTPRG	6.27e-05	186	100	5	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	PBMC-Mild-cDC_5\|Mild / Compartment, Disease Groups and Clusters	AGO2 DUSP4 PER1 RASSF5 MTHFR	6.43e-05	187	100	5	0afef5baf3752314dbfb024790347d5e51f9b84b
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-23\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNC TENM4 ALPK3 MTR NOTCH3	6.43e-05	187	100	5	69b47f00598d647e2a99427ebddf42c339428e47
ToppCell	368C-Epithelial_cells-Epithelial-I_(AT1)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	SIPA1L3 LAMA5 PTPRU TEP1 EPHA2	6.59e-05	188	100	5	c74771584b3ba9561a99a54bf55a9203ddf8eff8
ToppCell	368C-Epithelial_cells-Epithelial-I_(AT1)\|368C / Donor, Lineage, Cell class and subclass (all cells)	SIPA1L3 LAMA5 PTPRU TEP1 EPHA2	6.59e-05	188	100	5	9155b9a92496e75646778c025b02947e9e9ec73a
ToppCell	droplet-Limb_Muscle-nan-3m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A1 FLNC HK2 GAS1 GSTT1	6.59e-05	188	100	5	7191087d8754f5e8700e3d744cd920ee26db1e57
ToppCell	Pericytes-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	FLNC CSMD2 ACAN NEURL1B NOTCH3	6.59e-05	188	100	5	14c1c88a944c66f2eaac1ce7526815dcce1f5147
ToppCell	10x3'2.3-week_12-13-Mesenchymal_fibro-stroma-endosteal_fibroblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	COL6A1 GAS1 SEMA3G PTPRG SLCO2A1	6.76e-05	189	100	5	c392491aabe8a3e90974ab2ea123bbbe5200439d
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	FLNC NIBAN1 FBN2 ALPK3 MAPK4	6.76e-05	189	100	5	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	normal_Lymph_Node-Myeloid_cells-Activated_DCs\|normal_Lymph_Node / Location, Cell class and cell subclass	B4GALNT1 DUSP4 CHRNA7 TNFRSF11B LY75	6.93e-05	190	100	5	15978ddd37b521343f88b62dad1643077fc22b2b
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL6A1 GAS1 SVEP1 HIVEP3 EPHA1	7.11e-05	191	100	5	a05e9a7eb137d804570dd7d8905975d735738767
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	COL6A1 XDH SVEP1 HIVEP3 MTR	7.11e-05	191	100	5	e7c605b56934d1383237c1f946dbccef25d91368
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL6A1 GAS1 SVEP1 GSTT1 EPHA1	7.11e-05	191	100	5	d04e6292fef189b8d8ed0f4b0c310b2b250fd30e
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL6A1 GAS1 SVEP1 GSTT1 EPHA1	7.11e-05	191	100	5	de3e9b704621b26836c2ddc39fa3e840dfb4541b
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MANBA DUSP4 INSR PTPRU PTPRG	7.28e-05	192	100	5	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7-Tac2-Excitatory_Neuron.Slc17a7.Tac2.Htr2c_(Lateral_habenula)\|Thalamus / BrainAtlas - Mouse McCarroll V32	PCDHB8 CHRNA7 TNFRSF11B GUCY2C	7.35e-05	99	100	4	3dd31ed90bd1655cad954045afaef50de889008b
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	GAS1 SVEP1 TENM4 PTPRG NOTCH3	7.46e-05	193	100	5	cf2461af78f65616ce40d552ee9452295e3895ed
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	GAS1 SVEP1 TENM4 PTPRG NOTCH3	7.46e-05	193	100	5	6ef9007c9d18fb775d08fb20cdf954a28d54d7eb
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A1 FLNC CSMD2 ACAN CTRB1	7.46e-05	193	100	5	e5016959f24370579a8770787e96869f264cf7b3
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo-stroma-adipo-CAR\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	GAS1 SVEP1 TENM4 PTPRG NOTCH3	7.46e-05	193	100	5	e4ea7ce011a80b81b841c907719aa532bed39d2e
ToppCell	normal_Pleural_Fluid-Myeloid_cells-Activated_DCs\|normal_Pleural_Fluid / Location, Cell class and cell subclass	B4GALNT1 DUSP4 TNFRSF11B ALPK3 LY75	7.65e-05	194	100	5	219056d4ad256cda73208b8c570bbf689219df83
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPHB6 COL6A1 GAS1 SVEP1 TNFRSF11B	7.65e-05	194	100	5	79baee8b35b7707bbeb07c73b5e17b68bcd7bbc2
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPHB6 COL6A1 GAS1 SVEP1 TNFRSF11B	7.65e-05	194	100	5	f6e348f1f35c526cad6c349f1fdd0bd92d18aa3c
ToppCell	normal_Pleural_Fluid-Myeloid_cells-Activated_DCs\|Myeloid_cells / Location, Cell class and cell subclass	B4GALNT1 DUSP4 TNFRSF11B ALPK3 LY75	7.65e-05	194	100	5	30f683725cb13ae32ef6846618801ec78e12397d
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPHB6 COL6A1 GAS1 SVEP1 TNFRSF11B	7.65e-05	194	100	5	ce599ed0dc181aea0584e426636de5098f34ebe6
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL6A1 HK2 GAS1 SVEP1 GSTT1	7.65e-05	194	100	5	889c6e231bdd5b59902c7d2afdc077360b1d3256
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL6A1 GAS1 PER1 SVEP1 PTPRG	7.83e-05	195	100	5	ff0aa455e9844a6d7ae57ff59fb6cea825cf1fc2
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	NIBAN1 INSR FBN2 ALPK3 MAPK4	7.83e-05	195	100	5	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	facs-Skin-nan-18m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A1 NIBAN1 GAS1 SVEP1 TNFRSF11B	7.83e-05	195	100	5	ba7cb80deb872c9184769f0dd57855c3c6a432bf
ToppCell	Fibroblasts-Pericytes\|Fibroblasts / lung cells shred on cell class, cell subclass, sample id	NIBAN1 LAMA5 ACAN NEURL1B NOTCH3	7.83e-05	195	100	5	c2ebc0b33bda9b35b9ef26d69e5d2c6acfdb6ff1
ToppCell	ASK428-Epithelial-Transformed_epithelium\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	EPHB6 COL6A1 FLNC GAS1 TNFRSF11B	7.83e-05	195	100	5	c750602c765a51075ba6ede78e3ba80b62374481
ToppCell	15-Trachea-Epithelial-Epithelial\|Trachea / Age, Tissue, Lineage and Cell class	COL6A1 FLNC B4GALNT1 GAS1 TRIM36	7.83e-05	195	100	5	9e9283a397f56732a0a5f2e2527f154d4c2dd56a
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A1 NIBAN1 HK2 MYCBP2 GAS1	7.83e-05	195	100	5	5c86fddd6d0530beecf45ea5ba6b823123847696
ToppCell	E17.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL6A1 GAS1 SVEP1 HIVEP3 TENM4	8.03e-05	196	100	5	028a06ed92f1c058dcbeacd335625bf529e87a7b
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	COL6A1 CSMD2 SVEP1 TENM4 PTPRG	8.22e-05	197	100	5	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL6A1 NIBAN1 GAS1 GSTT1 TENM4	8.42e-05	198	100	5	ce59ee3d970397eb62d6387699c6c6cd65457898
ToppCell	Parenchymal-10x3prime_v2-Stromal-Mesofibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A1 FLNC CSMD2 FBN2 TENM4	8.42e-05	198	100	5	0cd930e374c2c48d1991b51c025f9801b22ecee7
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteoblast_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	COL6A1 SVEP1 TENM4 ACAN NOTCH3	8.42e-05	198	100	5	bc9c9f2c87282b5ef8514773e065d2a6b5dde338
ToppCell	Parenchymal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A1 FLNC CSMD2 FBN2 TENM4	8.42e-05	198	100	5	e0df6d6ff2a9c41d813f84a2a5ee7cb5f6fc3e30
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_only / Treatment groups by lineage, cell group, cell type	COL6A1 MYCBP2 SVEP1 TNFRSF11B HIVEP3	8.62e-05	199	100	5	fde2b65afde69f402f1b7b056eaa266e9fd5b227
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_activated\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TNFRSF11B MTHFR TONSL LY75 DHX34	8.62e-05	199	100	5	3b2bd3caf4d189a1726a737b0121860b265eec04
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRIM15 AMN XDH GUCY2C UNC5CL	8.62e-05	199	100	5	f26c20f5d7470e90eaa79613d0b87bd4865585a8
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	NIBAN1 CSMD2 TNFRSF11B ACAN NOTCH3	8.83e-05	200	100	5	9169a9ec8e9ab95d90a64c5a19ac666a5cf82313
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Dendritic_cell-DC_activated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	B4GALNT1 DUSP4 TNFRSF11B LY75 CHRFAM7A	8.83e-05	200	100	5	a4c41509ca936e137230a6ae548c90f18a566d12
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A1 GAS1 SVEP1 PTPRG TENM1	8.83e-05	200	100	5	b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte\|LPS_only / Treatment groups by lineage, cell group, cell type	NIBAN1 TNFRSF11B FBN2 ACAN NOTCH3	8.83e-05	200	100	5	8c8ef2b19ab5b1bfc0fae6c38a330f464f28e86f
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A1 GAS1 SVEP1 PTPRG TENM1	8.83e-05	200	100	5	0c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1E GALE DUSP4 XDH CHRNA7	8.83e-05	200	100	5	85c0f038bcfb42669dca2b80273b0f8a1421405e
ToppCell	Control-Epithelial_alveolar-AT_2-AT1-AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CFAP65 GUCY2C EPHA2 EPHA1	1.40e-04	117	100	4	c6fc72608d56a389bcd87b5dc98a11e39b79bcb2
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Fam19a1_Tmem182\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ZAN CHRNA7 FBN2 DSCC1	1.76e-04	124	100	4	690595d710b57b7cff8029a3bb06a8dd7e3c03c1
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HK2 SVEP1 SSC4D MAPK4	2.11e-04	130	100	4	e5acaa9aaa22b10d11410e2c01647b31354c21ed
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DENND5B SRD5A2 CFAP65 MARF1	2.43e-04	135	100	4	7743a01dc9c4542e910e7c0fe046004692a680bf
ToppCell	Cerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2\|Cerebellum / BrainAtlas - Mouse McCarroll V32	EPHA2 NEURL1B TRIM36 NOTCH3	2.57e-04	137	100	4	9324b55eac55e0cc1e8e450a4b5374d12e9587a3
ToppCell	Cerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Acta2Rgs5.Kcnj8_(Mural.Acta2Rgs5.Kcnj8)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	EPHA2 NEURL1B TRIM36 NOTCH3	2.57e-04	137	100	4	032f8409d0d179e254c8ff632afbda78852a9889
Computational	Genes in the cancer module 80.	EPHB6 INSR PTPRG EPHA2	4.10e-05	32	66	4	MODULE_80
Computational	Genes in the cancer module 51.	EPHB6 INSR PTPRG EPHA2	6.59e-05	36	66	4	MODULE_51
Computational	Placenta genes.	COL6A1 DUSP4 GAS1 PER1 LAMA5 PTPRU FBN2 MTHFR MARF1 NOTCH3	4.81e-04	463	66	10	MODULE_38
Drug	Colchicine [64-86-8]; Up 200; 10uM; MCF7; HT_HG-U133A	STRN3 MYO9B GRM8 WDR59 SVEP1 TNFRSF11B EPHA2 SLCO2A1 TRIM36	1.29e-07	189	98	9	5675_UP
Drug	fluorescein dilaurate	CACNA1E DUSP4 CTRB2 CTRB1	3.13e-07	14	98	4	CID000081743
Drug	glutamol-AMP	SRD5A2 CTRB2 CTRB1 NOTCH3	9.43e-07	18	98	4	CID005288456
Drug	AcPheOEt	INSR CTRB2 CTRB1	4.26e-06	8	98	3	CID000094229
Drug	alpha-zearalanol	EPHB6 ZAN PER1 PTPRG	7.06e-06	29	98	4	CID000022283
Drug	ciglitazone	HK2 INSR TNFRSF11B SSC4D SLCO2A1 TONSL MAPK4	8.60e-06	169	98	7	CID000002750
Drug	Ivermectin [70288-86-7]; Up 200; 4.6uM; MCF7; HT_HG-U133A	EPHB6 MYO9B DUSP4 SVEP1 TNFRSF11B MTHFR PPP1R37	1.21e-05	178	98	7	2213_UP
Drug	MDMA	COMT CHRNA7 TONSL TENM1 MAPK4 CHRFAM7A	1.41e-05	121	98	6	CID000001615
Drug	BOCPheONP	CTRB2 CTRB1	1.83e-05	2	98	2	CID000111308
Drug	MPM-06	CTRB2 CTRB1	1.83e-05	2	98	2	CID000161546
Drug	NSC-374899	CTRB2 CTRB1	1.83e-05	2	98	2	CID000435726
Drug	methylbenzenebutanoate	CTRB2 CTRB1	1.83e-05	2	98	2	CID000281254
Drug	Asp-Arg-Val-Tyr-Val-His-Pro-Phe-His-Leu	CTRB2 CTRB1	1.83e-05	2	98	2	CID004418081
Drug	c189	CTRB2 CTRB1	1.83e-05	2	98	2	CID000248048
Drug	dansyl-D-arginine methyl ester	CTRB2 CTRB1	1.83e-05	2	98	2	CID000191369
Drug	methyl 6-phenylhexanoate	CTRB2 CTRB1	1.83e-05	2	98	2	CID011820300
Drug	5-aminotetrazole	CTRB2 CTRB1	1.83e-05	2	98	2	CID000020467
Drug	2-bromoisobutyric acid	CTRB2 CTRB1	1.83e-05	2	98	2	CID000074924
Drug	8-azido-S-adenosylmethionine	COMT MTHFR	1.83e-05	2	98	2	CID000134870
Drug	p-toluamidine	CTRB2 CTRB1	1.83e-05	2	98	2	CID000122753
Drug	N-acetyl-alpha-azaphenylalanine phenyl ester	CTRB2 CTRB1	1.83e-05	2	98	2	CID000191275
Drug	isobutyl sulfide	CTRB2 CTRB1	1.83e-05	2	98	2	CID000011607
Drug	(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Up 200; 11.8uM; MCF7; HT_HG-U133A	COL6A1 FLNC DSG1 CTRB2 TNFRSF11B SLCO2A1 TRIM36	1.90e-05	191	98	7	4367_UP
Drug	homocysteine	EPHB6 COMT CHRNA7 MTHFR TONSL MTR CHRFAM7A NOTCH3	1.98e-05	266	98	8	CID000000778
Drug	olanzapine	COMT PER1 CHRNA7 MTHFR MAPK4 CHRFAM7A	2.02e-05	129	98	6	CID000004585
Drug	Trimeprazine tartrate [4330-99-8]; Up 200; 5.4uM; HL60; HT_HG-U133A	B4GALNT1 SIPA1L3 INSR GRM8 TNFRSF11B ACAN SLCO2A1	2.17e-05	195	98	7	2736_UP
Drug	Pimethixene maleate [13187-06-9]; Up 200; 9.8uM; MCF7; HT_HG-U133A	COL6A1 COMT DUSP4 XDH EHBP1L1 ACAN PPP1R37	2.17e-05	195	98	7	7468_UP
Drug	2-propylpentanoic acid; Up 200; 1000uM; MCF7; HT_HG-U133A	COL6A1 GAS1 GRM8 TNFRSF11B OTUD7B MTHFR NOTCH3	2.17e-05	195	98	7	5569_UP
Drug	Ascorbic acid [50-81-7]; Up 200; 22.4uM; MCF7; HT_HG-U133A	COL6A1 MYO9B SIPA1L3 XDH TENM1 PPP1R37 EPHA1	2.25e-05	196	98	7	3225_UP
Drug	Pimethixene maleate [13187-06-9]; Up 200; 9.8uM; MCF7; HT_HG-U133A	COMT MYO9B SIPA1L3 DUSP4 TEP1 MTHFR PPP1R37	2.25e-05	196	98	7	7426_UP
Drug	Amrinone [60719-84-8]; Up 200; 21.4uM; HL60; HT_HG-U133A	GAS1 XDH ACAN SLCO2A1 TTLL4 PPP1R37 MUC2	2.25e-05	196	98	7	2724_UP
Drug	Ethambutol dihydrochloride [1070-11-7]; Down 200; 14.4uM; MCF7; HT_HG-U133A	STRN3 GSTT1 EHBP1L1 TTLL4 TRIM36 DHX34 VCPIP1	2.25e-05	196	98	7	4120_DN
Drug	Pyrazinamide [ 98-96-4]; Up 200; 32.4uM; HL60; HT_HG-U133A	EPHB6 DENND5B STRN3 SIPA1L3 DUSP4 SVEP1 DHX34	2.25e-05	196	98	7	2478_UP
Drug	Azaperone [1649-18-9]; Down 200; 12.2uM; MCF7; HT_HG-U133A	COMT MYO9B SIPA1L3 PTPRU HIVEP3 NOTCH3 EPHA1	2.32e-05	197	98	7	3573_DN
Drug	haloperidol; Down 200; 10uM; HL60; HT_HG-U133A	COMT DUSP4 PER1 XDH FBN2 MTHFR SLCO2A1	2.32e-05	197	98	7	2704_DN
Drug	Dimethisoquin hydrochloride [2773-92-4]; Down 200; 13uM; PC3; HT_HG-U133A	EPHB6 COL6A1 SIPA1L3 PER1 TNFRSF11B TENM4 NOTCH3	2.32e-05	197	98	7	4207_DN
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Down 200; 13.8uM; MCF7; HT_HG-U133A	STRN3 MYO9B GRM8 TNFRSF11B MTHFR PLCG1 DHX34	2.32e-05	197	98	7	4764_DN
Drug	Trichlormethiazide [133-67-5]; Down 200; 10.6uM; MCF7; HT_HG-U133A	COL6A1 MYO9B DUSP4 PER1 HIVEP3 EPHA2 TRIM36	2.32e-05	197	98	7	3337_DN
Drug	Sulfachloropyridazine [80-32-0]; Down 200; 14uM; PC3; HT_HG-U133A	COL6A1 STRN3 ZNF467 TEP1 FBN2 ACAN NOTCH3	2.32e-05	197	98	7	3769_DN
Drug	3-Acetylcoumarin [3949-36-8]; Down 200; 21.2uM; MCF7; HT_HG-U133A	COMT MYO9B INSR TEP1 TRIM36 DHX34 EPHA1	2.40e-05	198	98	7	5259_DN
Drug	Nomegestrol acetate [58652-20-3]; Up 200; 10.8uM; MCF7; HT_HG-U133A	COL6A1 PER1 WDR59 SVEP1 TENM4 DHX34 EPHA1	2.40e-05	198	98	7	6525_UP
Drug	PHA-00745360 [351320-33-7]; Up 200; 1uM; MCF7; HT_HG-U133A	MYO9B PER1 XDH SEMA3G SLCO2A1 PPP1R37 TRIM36	2.40e-05	198	98	7	4384_UP
Drug	Aceclofenac [89796-99-6]; Up 200; 11.2uM; MCF7; HT_HG-U133A	COL6A1 MYO9B SIPA1L3 MTHFR SLCO2A1 MUC2 DHX34	2.40e-05	198	98	7	2281_UP
Drug	Proparacaine hydrochloride [5875-06-9]; Up 200; 12uM; MCF7; HT_HG-U133A	COL6A1 NIBAN1 GAS1 PER1 XDH TENM1 PLCG1	2.48e-05	199	98	7	6492_UP
Drug	LY 294002; Up 200; 10uM; HL60; HT_HG-U133A	COL6A1 LAMA5 MTHFR ACAN SLCO2A1 TENM1 TRIM36	2.48e-05	199	98	7	6186_UP
Drug	Metixene hydrochloride [1553-34-0]; Down 200; 11.6uM; PC3; HT_HG-U133A	GRM8 TENM4 MTHFR ACAN PLCG1 DHX34 EPHA1	2.48e-05	199	98	7	6672_DN
Drug	Brompheniramine maleate [980-71-2]; Up 200; 9.2uM; MCF7; HT_HG-U133A	COL6A1 COMT PER1 XDH SVEP1 MTHFR DHX34	2.48e-05	199	98	7	3271_UP
Drug	risperidone	COMT PER1 CHRNA7 MTHFR TONSL CHRFAM7A	2.73e-05	136	98	6	CID000005073
Drug	anatoxin-a hydrochloride	DUSP4 CHRNA7 CHRFAM7A	3.39e-05	15	98	3	CID000135265
Drug	sulfate	EPHB6 COL6A1 MANBA COMT AZU1 INSR CTRB2 LAMA5 CHRNA7 SSC4D PTPRG ACAN TONSL PGLS PLCG1 CTRB1 CHRFAM7A	3.41e-05	1292	98	17	CID000001117
Drug	vitamin B12b	AMN XDH MTHFR MTR	3.84e-05	44	98	4	CID004479097
Drug	soman	COMT CTRB2 CHRNA7 CTRB1 CHRFAM7A	4.87e-05	92	98	5	CID000007305
Drug	Methyl-1 (S-methylphosphoryl-3) imidazolium	COMT CTRB2 ADH5 GSTT1 PTPRG CTRB1	4.91e-05	151	98	6	CID000051213
Drug	Clobenosido	COMT FCSK	5.49e-05	3	98	2	CID000065769
Drug	N-acetylbenzotriazole	CTRB2 CTRB1	5.49e-05	3	98	2	CID000087784
Drug	photophor	CTRB2 CTRB1	5.49e-05	3	98	2	CID000014780
Drug	dibutyl iodomethaneboronate	CTRB2 CTRB1	5.49e-05	3	98	2	CID000098591
Drug	zinc;dipicolinate	CTRB2 CTRB1	5.49e-05	3	98	2	CID004309911
Drug	2-oxobut-3-ynoate	CTRB2 CTRB1	5.49e-05	3	98	2	CID000171547
Drug	AFMeq	CTRB2 CTRB1	5.49e-05	3	98	2	CID000194069
Drug	Bz-Cti-otbu	CTRB2 CTRB1	5.49e-05	3	98	2	CID006452691
Drug	n-(2-oxoethyl)benzamide	CTRB2 CTRB1	5.49e-05	3	98	2	CID000188995
Drug	AC1L49DM	CTRB2 CTRB1	5.49e-05	3	98	2	CID000152933
Drug	c140	CTRB2 CTRB1	5.49e-05	3	98	2	CID002783250
Drug	Benzamidomethaneboronic acid	CTRB2 CTRB1	5.49e-05	3	98	2	CID000127677
Drug	phenyl hippurate	CTRB2 CTRB1	5.49e-05	3	98	2	CID000076323
Drug	FK-386	CTRB2 CTRB1	5.49e-05	3	98	2	CID000135044
Drug	FK-375	CTRB2 CTRB1	5.49e-05	3	98	2	CID000135042
Drug	carbostyril-124	CTRB2 CTRB1	5.49e-05	3	98	2	CID000088277
Drug	N-trifluoroacetyl-4-fluorophenylalanine	CTRB2 CTRB1	5.49e-05	3	98	2	CID000328214
Drug	C18 4	CTRB2 CTRB1	5.49e-05	3	98	2	CID000077248
Drug	taraxastane	CTRB2 CTRB1	5.49e-05	3	98	2	CID006429404
Drug	Phe-phe-ome	CTRB2 CTRB1	5.49e-05	3	98	2	CID000151728
Drug	phenylethaneboronic acid	CTRB2 CTRB1	5.49e-05	3	98	2	CID000065389
Drug	3-amino-2-pyridone	CTRB2 CTRB1	5.49e-05	3	98	2	CID000322353
Drug	ASA-BMPA	CTRB2 CTRB1	5.49e-05	3	98	2	CID003035649
Drug	p-nitrophenyl benzoate	CTRB2 CTRB1	5.49e-05	3	98	2	CID000070396
Drug	Z-Phe-OMe	CTRB2 CTRB1	5.49e-05	3	98	2	CID003082435
Drug	3-methylcoumarin	CTRB2 CTRB1	5.49e-05	3	98	2	CID000017130
Drug	2-propyl methylphosphonochloridate	CTRB2 CTRB1	5.49e-05	3	98	2	CID000102124
Drug	FK-316	CTRB2 CTRB1	5.49e-05	3	98	2	CID000133688
Drug	AC1L19T8	CTRB2 CTRB1	5.49e-05	3	98	2	CID000000694
Drug	Marinostatin D	CTRB2 CTRB1	5.49e-05	3	98	2	CID000132206
Drug	1FD7	CTRB2 CTRB1	5.49e-05	3	98	2	CID000445579
Drug	Glt-leu-phe-nh-meq	CTRB2 CTRB1	5.49e-05	3	98	2	CID000194914
Drug	AC1L4Z4F	CTRB2 CTRB1	5.49e-05	3	98	2	CID000194913
Drug	Glt-Phe-NH-FMeq	CTRB2 CTRB1	5.49e-05	3	98	2	CID000194912
Drug	diacetyl trimer	CTRB2 CTRB1	5.49e-05	3	98	2	CID000193527
Drug	FK-448	CTRB2 CTRB1	5.49e-05	3	98	2	CID006917869
Drug	Ac-Phe-OMe	CTRB2 CTRB1	5.49e-05	3	98	2	CID000097805
Drug	thiobenzyl N-heptafluorobutyrylanthranilate	CTRB2 CTRB1	5.49e-05	3	98	2	CID000133906
Drug	Moldin	COMT CHRNA7 MTHFR CHRFAM7A	6.38e-05	50	98	4	CID000026331
Drug	G-G-G	COMT CHRNA7 MTHFR CHRFAM7A	6.38e-05	50	98	4	CID000448212
Drug	hexitol	GALE HK2 XDH ADH5 TONSL PGLS MTR	8.77e-05	243	98	7	CID000000453
Drug	AC1L4O4Q	COMT PGLS MTR	9.72e-05	21	98	3	CID000189139
Drug	Benzoyl-dl-leucine	CTRB2 CTRB1	1.09e-04	4	98	2	CID000294887
Drug	Acafcek	CTRB2 CTRB1	1.09e-04	4	98	2	CID000197677
Drug	B-1,3-od	CTRB2 CTRB1	1.09e-04	4	98	2	CID011971053
Drug	dehydromerodesmosine	CTRB2 CTRB1	1.09e-04	4	98	2	CID006443540
Drug	alpha-amyrin palmitate	CTRB2 CTRB1	1.09e-04	4	98	2	CID000185477
Disease	mean arterial pressure	NIBAN1 MYO9B DUSP4 INSR SVEP1 HIVEP3 FCSK FBN2 MTHFR MAPK4 TRIM36 RNF32-DT	9.31e-08	499	97	12	EFO_0006340
Disease	cognitive disorder (implicated_via_orthology)	COMT CHRNA7 CHRFAM7A	6.84e-07	6	97	3	DOID:1561 (implicated_via_orthology)
Disease	trypsin-2 measurement	EPHB6 CTRB2 CTRB1	5.57e-06	11	97	3	EFO_0008305
Disease	level of chymotrypsinogen B2 in blood serum	CTRB2 CTRB1	1.07e-05	2	97	2	OBA_2041192
Disease	Colorectal Carcinoma	EPHB6 FLNC PER1 PTPRU HIVEP3 FBN2 GUCY2C MTHFR SLCO2A1 TENM1 EPHA1	1.99e-05	702	97	11	C0009402
Disease	Malnutrition	MTHFR MTR	3.20e-05	3	97	2	C0162429
Disease	chymotrypsinogen B measurement	CTRB2 CTRB1	3.20e-05	3	97	2	EFO_0801477
Disease	connective tissue disease (implicated_via_orthology)	FBN2 FBN3	3.20e-05	3	97	2	DOID:65 (implicated_via_orthology)
Disease	hyperhomocysteinemia (is_implicated_in)	MTHFR MTR	3.20e-05	3	97	2	DOID:9279 (is_implicated_in)
Disease	Schizophrenia	COMT MYO9B SRD5A2 CSMD2 GRM8 CHRNA7 CFAP65 GSTT1 TENM4 MTHFR MTR CHRFAM7A	3.31e-05	883	97	12	C0036341
Disease	attention deficit hyperactivity disorder (is_implicated_in)	COMT GRM8 MTHFR	3.77e-05	20	97	3	DOID:1094 (is_implicated_in)
Disease	cardiovascular system disease (is_implicated_in)	XDH GSTT1 MTHFR	4.39e-05	21	97	3	DOID:1287 (is_implicated_in)
Disease	Neural tube defects, folate-sensitive	MTHFR MTR	6.39e-05	4	97	2	cv:C1866558
Disease	Anencephaly	MTHFR TRIM36	6.39e-05	4	97	2	C0002902
Disease	Neural tube defect, folate-sensitive	MTHFR MTR	6.39e-05	4	97	2	C1866558
Disease	NEURAL TUBE DEFECTS, FOLATE-SENSITIVE	MTHFR MTR	6.39e-05	4	97	2	601634
Disease	Seizures	CACNA1E CHRNA7 FCSK MTHFR MTR NOTCH3	8.57e-05	218	97	6	C0036572
Disease	Affective Disorders, Psychotic	COMT MTHFR	1.06e-04	5	97	2	C0001723
Disease	urinary bladder cancer (is_implicated_in)	XDH GSTT1 MTHFR MTR	1.17e-04	76	97	4	DOID:11054 (is_implicated_in)
Disease	schizophrenia (is_implicated_in)	COMT GRM8 CHRNA7 MTHFR	1.30e-04	78	97	4	DOID:5419 (is_implicated_in)
Disease	serum alanine aminotransferase measurement	MANBA INSR SRD5A2 LAMA5 XDH OTUD7B FCSK TENM4 UNC5CL EPHA2 MARF1	1.35e-04	869	97	11	EFO_0004735
Disease	rheumatoid arthritis (biomarker_via_orthology)	CHRNA7 CHRFAM7A	1.59e-04	6	97	2	DOID:7148 (biomarker_via_orthology)
Disease	spina bifida (is_implicated_in)	MTHFR MTR	1.59e-04	6	97	2	DOID:0080016 (is_implicated_in)
Disease	Bipolar Disorder	COMT CHRNA7 GSTT1 TENM4 MTHFR MTR PLCG1 CHRFAM7A	1.81e-04	477	97	8	C0005586
Disease	pulse pressure measurement	COL6A1 INSR LAMA5 PCDHA7 SVEP1 HIVEP3 FCSK FBN2 TENM4 MTHFR NEURL1B MAPK4 DHX34 NOTCH3	1.81e-04	1392	97	14	EFO_0005763
Disease	Mental Depression	COMT DUSP4 CSMD2 GSTT1 MTHFR MTR	1.97e-04	254	97	6	C0011570
Disease	X-24494 measurement	SRD5A2 XDH	2.22e-04	7	97	2	EFO_0800889
Disease	Autistic Disorder	COMT PER1 XDH GRM8 CHRNA7 MTHFR	2.28e-04	261	97	6	C0004352
Disease	Lung Neoplasms	COL6A1 TEP1 CHRNA7 GSTT1 MTHFR NOTCH3	2.47e-04	265	97	6	C0024121
Disease	Malignant neoplasm of lung	COL6A1 TEP1 CHRNA7 GSTT1 MTHFR NOTCH3	2.53e-04	266	97	6	C0242379
Disease	Alcoholic Intoxication, Chronic	AGO2 COMT SRD5A2 GRM8 ADH5 MTHFR	2.63e-04	268	97	6	C0001973
Disease	pancreatitis (biomarker_via_orthology)	CTRB2 XDH CTRB1	2.89e-04	39	97	3	DOID:4989 (biomarker_via_orthology)
Disease	hypospadias (is_implicated_in)	SRD5A2 GSTT1	2.96e-04	8	97	2	DOID:10892 (is_implicated_in)
Disease	Hematological Disease	MTHFR MTR	2.96e-04	8	97	2	C0018939
Disease	Colorectal Neoplasms	FLNC FBN2 GUCY2C MTHFR SLCO2A1 EPHA1	3.14e-04	277	97	6	C0009404
Disease	Acute Confusional Senile Dementia	INSR CHRNA7 MTHFR EPHA1	3.25e-04	99	97	4	C0546126
Disease	Alzheimer's Disease, Focal Onset	INSR CHRNA7 MTHFR EPHA1	3.25e-04	99	97	4	C0750900
Disease	Alzheimer Disease, Early Onset	INSR CHRNA7 MTHFR EPHA1	3.25e-04	99	97	4	C0750901
Disease	Presenile dementia	INSR CHRNA7 MTHFR EPHA1	3.25e-04	99	97	4	C0011265
Disease	Alzheimer Disease, Late Onset	INSR CHRNA7 MTHFR EPHA1	3.25e-04	99	97	4	C0494463
Disease	Familial Alzheimer Disease (FAD)	INSR CHRNA7 MTHFR EPHA1	3.38e-04	100	97	4	C0276496
Disease	Alzheimer's Disease	INSR CHRNA7 MTHFR EPHA1	3.51e-04	101	97	4	C0002395
Disease	Depressive disorder	COMT DUSP4 CSMD2 GSTT1 MTHFR MTR	3.93e-04	289	97	6	C0011581
Disease	Leukoencephalopathy	MTHFR MTR	5.77e-04	11	97	2	C0270612
Disease	SCHIZOPHRENIA	COMT MTHFR	5.77e-04	11	97	2	181500
Disease	Tourette syndrome	ZNF577 PTPRU TENM4	6.03e-04	50	97	3	EFO_0004895
Disease	Pulmonary Thromboembolisms	XDH MTHFR	6.91e-04	12	97	2	C0524702
Disease	Pulmonary Embolism	XDH MTHFR	6.91e-04	12	97	2	C0034065
Disease	chronic kidney disease (implicated_via_orthology)	INSR XDH	6.91e-04	12	97	2	DOID:784 (implicated_via_orthology)
Disease	Gastrointestinal Diseases	MTHFR MTR	6.91e-04	12	97	2	C0017178
Disease	nicotine dependence (implicated_via_orthology)	CHRNA7 CHRFAM7A	6.91e-04	12	97	2	DOID:0050742 (implicated_via_orthology)
Disease	11beta-hydroxyandrosterone glucuronide measurement	SRD5A2 XDH	6.91e-04	12	97	2	EFO_0800573
Disease	Functional Gastrointestinal Disorders	MTHFR MTR	6.91e-04	12	97	2	C0559031
Disease	Cholera Infantum	MTHFR MTR	6.91e-04	12	97	2	C1565321
Disease	diffuse large B-cell lymphoma (is_implicated_in)	GSTT1 MTHFR	6.91e-04	12	97	2	DOID:0050745 (is_implicated_in)
Disease	hypertension (is_implicated_in)	COMT XDH GSTT1 MTR	6.95e-04	121	97	4	DOID:10763 (is_implicated_in)
Disease	Calcium channel blocker use measurement	INSR SVEP1 FBN2 MTHFR TRIM36	7.03e-04	213	97	5	EFO_0009930
Disease	acute lymphoblastic leukemia (is_implicated_in)	GSTT1 MTHFR MTR	7.98e-04	55	97	3	DOID:9952 (is_implicated_in)
Disease	X-11444 measurement	SRD5A2 XDH	8.15e-04	13	97	2	EFO_0021237
Disease	Childhood Ataxia with Central Nervous System Hypomyelinization	MTHFR MTR	9.49e-04	14	97	2	C1858991
Disease	chronic kidney disease (is_implicated_in)	XDH MTHFR	9.49e-04	14	97	2	DOID:784 (is_implicated_in)
Disease	multiple myeloma (is_implicated_in)	GSTT1 MTHFR MTR	9.80e-04	59	97	3	DOID:9538 (is_implicated_in)
Disease	Alopecia, Male Pattern	SRD5A2 MTHFR	1.09e-03	15	97	2	C4083212
Disease	Lymphoma, Follicular, Grade 2	MTHFR MTR	1.09e-03	15	97	2	C1956132
Disease	Lymphoma, Follicular, Grade 3	MTHFR MTR	1.09e-03	15	97	2	C1956131
Disease	Lymphoma, Follicular, Grade 1	MTHFR MTR	1.09e-03	15	97	2	C1956130
Disease	Lymphoma, Large-Cell, Follicular	MTHFR MTR	1.09e-03	15	97	2	C0079745
Disease	Lymphoma, Small Cleaved-Cell, Follicular	MTHFR MTR	1.09e-03	15	97	2	C0079765
Disease	Lymphoma, Mixed-Cell, Follicular	MTHFR MTR	1.09e-03	15	97	2	C0079758
Disease	Androgenetic Alopecia	SRD5A2 MTHFR	1.09e-03	15	97	2	C0162311
Disease	Female pattern alopecia (disorder)	SRD5A2 MTHFR	1.09e-03	15	97	2	C0263477
Disease	glycine measurement	INSR GRM8 TENM4 MTHFR	1.10e-03	137	97	4	EFO_0009767
Disease	Congenital total cataract	SIPA1L3 EPHA2	1.25e-03	16	97	2	C0266539
Disease	sickle cell anemia (is_implicated_in)	GSTT1 MTHFR	1.25e-03	16	97	2	DOID:10923 (is_implicated_in)
Disease	pre-malignant neoplasm (biomarker_via_orthology)	INSR MUC2	1.41e-03	17	97	2	DOID:0060071 (biomarker_via_orthology)
Disease	Kuhnt-Junius degeneration (is_implicated_in)	GSTT1 MTHFR	1.41e-03	17	97	2	DOID:10873 (is_implicated_in)
Disease	renal cell carcinoma (is_implicated_in)	COMT GSTT1 MTHFR	1.54e-03	69	97	3	DOID:4450 (is_implicated_in)
Disease	Schizophrenia	COMT MTHFR	1.58e-03	18	97	2	cv:C0036341
Disease	Manic Disorder	COMT TENM4 MTHFR	1.67e-03	71	97	3	C0024713
Disease	inflammatory bowel disease (is_implicated_in)	GSTT1 MTHFR	1.76e-03	19	97	2	DOID:0050589 (is_implicated_in)
Disease	laryngeal squamous cell carcinoma (is_marker_for)	XDH PLCG1	1.76e-03	19	97	2	DOID:2876 (is_marker_for)
Disease	Pseudopelade	SRD5A2 MTHFR	1.76e-03	19	97	2	C0086873
Disease	Alopecia	SRD5A2 MTHFR	1.76e-03	19	97	2	C0002170
Disease	etiocholanolone glucuronide measurement	SRD5A2 XDH	1.76e-03	19	97	2	EFO_0800362
Disease	smoking status measurement, systolic blood pressure	INSR TENM4 MTHFR TRIM36	1.78e-03	156	97	4	EFO_0006335, EFO_0006527
Disease	asthma (is_implicated_in)	ADH5 GSTT1 MTHFR MUC2	1.82e-03	157	97	4	DOID:2841 (is_implicated_in)
Disease	Lymphoma, Follicular	MTHFR MTR	1.96e-03	20	97	2	C0024301
Disease	interleukin 18 measurement	SRD5A2 XDH WDR59	2.03e-03	76	97	3	EFO_0004581
Disease	Manic	COMT TENM4 MTHFR	2.19e-03	78	97	3	C0338831
Disease	preeclampsia	MYCBP2 TENM4 MTHFR	2.19e-03	78	97	3	EFO_0000668
Disease	Depression, Bipolar	COMT TENM4 MTHFR	2.27e-03	79	97	3	C0005587
Disease	Attention Deficit Disorder	COMT GRM8	2.37e-03	22	97	2	C0041671
Disease	Minimal Brain Dysfunction	COMT GRM8	2.37e-03	22	97	2	C1321905
Disease	type 2 diabetes mellitus (is_implicated_in)	HK2 INSR GSTT1 MTHFR	2.48e-03	171	97	4	DOID:9352 (is_implicated_in)
Disease	Allodynia	COMT INSR TNFRSF11B	2.71e-03	84	97	3	C0458247
Disease	Mechanical Allodynia	COMT INSR TNFRSF11B	2.71e-03	84	97	3	C2936719
Disease	Hyperalgesia, Secondary	COMT INSR TNFRSF11B	2.71e-03	84	97	3	C0751212
Disease	Hyperalgesia, Primary	COMT INSR TNFRSF11B	2.71e-03	84	97	3	C0751211
Disease	Hyperalgesia, Thermal	COMT INSR TNFRSF11B	2.71e-03	84	97	3	C0751214
Disease	Tactile Allodynia	COMT INSR TNFRSF11B	2.71e-03	84	97	3	C0751213

Protein segments in the cluster

Peptide	Gene	Start	Entry
PETGPVLVHCSAGVG	PTPRG	1051	P23470
HVVIAGPQDSPFEGG	UBE2N	36	P61088
GHIPAAPGETGSVIC	nan	81	Q8N814
TFGCGVPAIHPVLSG	CTRB2	16	Q6GPI1
PAGLVEVAGTCLPHA	EPHA1	221	P21709
SVGVCGDPGIPAHGI	CSMD2	2831	Q7Z408
SGILEGFDPPHPCGV	CACNA1E	256	Q15878
ILGVGPDGHTCSLFP	PGLS	146	O95336
HELVGFPGCVVTDGV	B4GALNT1	421	Q00973
DPEGCFPVILGHEGA	ADH5	56	P11766
CGGAAQTGDPVALPH	DNAH10OS	46	P0CZ25
PPHEGSVEQVGGERC	ALPK3	1006	Q96L96
RFHGPGALSVGPEDC	AMN	191	Q9BXJ7
EVPEGLQLHPVGCGT	DNAI1	486	Q9UI46
ELCPFGHGAVPGPDD	FBN3	2066	Q75N90
GLDGVHCVPTPDSGV	CHRNA7	391	P36544
VIFLGADVTHPPAGD	AGO2	591	Q9UKV8
AHLGLGPGCFPAVAV	RNF32-DT	106	Q8NI28
GAGEDCQIFSTPGHP	RBM27	771	Q9P2N5
EGHCFAELVLPGGPG	RASSF5	121	Q8WWW0
IGVHSGPCAAGVVGI	GUCY2C	921	P25092
ECPFPGHLVDVSGTG	PCDHB18P	676	Q96TA0
GFPPLAGHCTVLVEV	PCDHA7	326	Q9UN72
FTIPRPSGGGVHCQE	OTUD7B	696	Q6GQQ9
DICVAGYPKGHPEAG	MTHFR	191	P42898
LGDLNGACIPEHPGD	MAPK4	561	P31152
AFSCPTAHGIVLPGE	CFAP65	406	Q6ZU64
PHEVFGCVVPEGGSQ	EZHIP	106	Q86X51
GFEDPHCEVGLIVGT	HK2	666	P52789
VHSPSPTGLCGVGAV	PER1	501	O15534
GCVGPDNVPREFGEH	MUC2	4816	Q02817
KAFGPGLEPTGCIVD	FLNC	671	Q14315
EHGGRCESAPGQLPV	NOTCH3	781	Q9UM47
CPQEGTEAHGARLGP	EHBP1L1	346	Q8N3D4
GEDAHLCPTLGPGVR	PDZD3	206	Q86UT5
EHGFGRVVCKVPLGP	LY75	1651	O60449
ACAPVLAQHGGGDAP	GAS1	71	P54826
AGHLYPGEVCPGMDI	INSR	26	P06213
HEVGATGPTCEPFGG	LAMA5	1441	O15230
LFPVHAKGERGVPCG	GRM8	51	O00222
GLDGVHCVPTPDSGV	CHRFAM7A	301	Q494W8
AGFEPVPECSDGAIH	DSG1	581	Q02413
TEGHVICLCPPGYTG	ACAN	2296	P16112
ACGEPPVVEHARTFG	ACAN	2446	P16112
PDAGPIVIHCSAGTG	PTPRU	1076	Q92729
PGPEVKGGSCGLEHE	PPP1R37	651	O75864
VICPGAPDFLAHVRG	COMT	221	P21964
GPIHIGAGCLVTGLD	FCSK	391	Q8N0W3
AHASGCIGEDPQGIP	GALE	191	Q14376
ELLPAVHCLGFGPGA	DSCC1	21	Q9BVC3
VTDGHPLEGYKEPCG	COL6A1	156	P12109
VAGTCVDHAVVPPGG	EPHA2	226	P29317
PGGFGIAPHCLDEGT	CENPV	231	Q7Z7K6
VQFGIPPEGSLHCSE	DENND5B	401	Q6ZUT9
GSLELPGAVPGCVHS	MANBA	36	O00462
GGVPLEHFITCVPGV	MARF1	1046	Q9Y4F3
ICPHGPGYTTDGRDI	FBN2	2436	P35556
GGTPLVCEGLAHGVA	AZU1	201	P20160
GAVLHPTCVFAGSPE	DHX34	836	Q14147
CGTPLHDQGGPVEIL	DUSP4	186	Q13115
DCFTGHGVAPGTGPV	SPACA4	46	Q8TDM5
AFGCGVPAIHPVLSG	CTRB1	16	P17538
CSVPEGPFPGHLVDV	PCDHB8	726	Q9UN66
HPVGAGCQVFEGRPK	GSTT1	176	P30711
CDPGASVDIVVSPHG	MOSPD2	381	Q8NHP6
HGIPTSVDFIGCDPA	STRN3	631	Q13033
TVFPCPGCEHDVDLG	TRIM36	111	Q9NQ86
TFEACHVAGAPPGTG	EPHB6	71	O15197
GEGFVISVSHGEPLC	MTR	241	Q99707
ASCGARVGDVLPGPH	SIPA1L3	16	O60292
VPEEQCIDPTCFGHG	TENM1	591	Q9UKZ4
VVHPPTGEEFALGCG	MYCBP2	4656	O75592
IDCGLPPHIDFGDCT	SVEP1	2611	Q4LDE5
CGKPESPEHGFVVGS	SVEP1	3241	Q4LDE5
HSGFGLFCGDPGPEI	CLUHP3	46	Q96NS8
PDSIFHPVCGDNGIE	SLCO2A1	451	Q92959
HRSCPPGFGVVQAGT	TNFRSF11B	121	O00300
FPCGTELRGHEGPVS	TEP1	2051	Q99973
PCPEAHGEELGGFPE	NIBAN1	776	Q9BZQ8
SVPHVCARFGPGGQL	SEC16A	1446	O15027
HEDAGALCAGLGPPT	SSC4D	281	Q8WTU2
PGGQGCEGITPLHDA	TONSL	591	Q96HA7
PGIAEGAAHSQICPG	ZNF577	81	Q9BSK1
GPLEDAVTIPCGHTF	TRIM15	21	Q9C019
GEPVLFHCGVAVGGP	NEURL1B	161	A8MQ27
TTVCGADVHEVGPGP	HIVEP3	1366	Q5T1R4
AQGLVSPVVACGPHG	UNC5CL	156	Q8IV45
GCGPGAPSDAEVLHL	PLCG1	11	P19174
PGENPFDGGHACVIR	TENM4	911	Q6N022
FGPPGTVLLGLFCVH	SRD5A2	76	P31213
EHGPDGISFGAACPL	XDH	291	P47989
LCVDAAGHFPIGPDV	VCPIP1	961	Q96JH7
VLFGFAVHPEPEACG	PAK1IP1	11	Q9NWT1
CPFEDVLGVGHTGGI	WDR46	456	O15213
VSCPPDPHKGIEFGV	WDR59	886	Q6PJI9
GGVSLGPAFVKACEP	ZSCAN22	166	P10073
FVPSSVPEGCVHKPG	UNQ6494/PRO21346	136	Q6UXR6
DTCFVSGVHGPVALG	ZNF213	191	O14771
RLVCSVPGPGGAETH	SEMA3G	291	Q9NS98
GGTGDCAPQPVDHKV	TTLL4	256	Q14679
VRCGGHPSVELPGYA	TMEM271	341	A0A286YF58
PPESHVCGEVGVGYP	ZNF861P	36	O60384
LGVCSGHEAPTPEEG	ZNF467	46	Q7Z7K2
GPGFCGRLVDTHGPF	ZAN	1351	Q9Y493
PGVEPGHFGVCVDSL	MYO9B	1691	Q13459