Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	complement component C3b binding	CFH CFHR1 CFHR4 CFHR3	3.34e-08	12	59	4	GO:0001851
GeneOntologyMolecularFunction	opsonin binding	CFH CFHR1 CFHR4 CFHR3	8.30e-07	25	59	4	GO:0001846
GeneOntologyMolecularFunction	complement binding	CFH CFHR1 CFHR4 CFHR3	2.32e-06	32	59	4	GO:0001848
GeneOntologyMolecularFunction	heparan sulfate proteoglycan binding	CFH CEACAM21 CFHR4	8.48e-05	29	59	3	GO:0043395
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	RSF1 CHD9 ARID1A	1.77e-04	37	59	3	GO:0140658
GeneOntologyMolecularFunction	proteoglycan binding	CFH CEACAM21 CFHR4	4.61e-04	51	59	3	GO:0043394
GeneOntologyBiologicalProcess	complement activation	CFH CFHR1 CD55 C4BPB CFHR4 CFHR3	4.32e-08	70	58	6	GO:0006956
GeneOntologyBiologicalProcess	regulation of complement activation	CFH CD55 C4BPB CFHR4	9.41e-07	27	58	4	GO:0030449
GeneOntologyBiologicalProcess	sensory organ development	CFH MYOM1 GJB6 JAG1 ARID1A CDH1 GDF11 CRB2 SMAD3 OC90 CFHR4	5.05e-06	730	58	11	GO:0007423
GeneOntologyBiologicalProcess	regulation of complement-dependent cytotoxicity	CFH CD55 CFHR4	5.92e-06	13	58	3	GO:1903659
GeneOntologyBiologicalProcess	camera-type eye morphogenesis	CFH JAG1 ARID1A GDF11 CRB2 CFHR4	8.42e-06	171	58	6	GO:0048593
GeneOntologyBiologicalProcess	complement-dependent cytotoxicity	CFH CD55 CFHR4	1.15e-05	16	58	3	GO:0097278
GeneOntologyBiologicalProcess	eye morphogenesis	CFH JAG1 ARID1A GDF11 CRB2 CFHR4	2.29e-05	204	58	6	GO:0048592
GeneOntologyBiologicalProcess	camera-type eye development	CFH MYOM1 JAG1 ARID1A GDF11 CRB2 SMAD3 CFHR4	2.41e-05	426	58	8	GO:0043010
GeneOntologyBiologicalProcess	regulation of humoral immune response	CFH CD55 C4BPB CFHR4	2.44e-05	60	58	4	GO:0002920
GeneOntologyBiologicalProcess	sensory organ morphogenesis	CFH GJB6 JAG1 ARID1A GDF11 CRB2 CFHR4	4.80e-05	343	58	7	GO:0090596
GeneOntologyBiologicalProcess	eye development	CFH MYOM1 JAG1 ARID1A GDF11 CRB2 SMAD3 CFHR4	5.60e-05	480	58	8	GO:0001654
GeneOntologyBiologicalProcess	visual system development	CFH MYOM1 JAG1 ARID1A GDF11 CRB2 SMAD3 CFHR4	5.85e-05	483	58	8	GO:0150063
GeneOntologyBiologicalProcess	sensory system development	CFH MYOM1 JAG1 ARID1A GDF11 CRB2 SMAD3 CFHR4	6.57e-05	491	58	8	GO:0048880
GeneOntologyBiologicalProcess	activation of membrane attack complex	CFH CFHR4	1.16e-04	6	58	2	GO:0001905
GeneOntologyBiologicalProcess	regulation of complement activation, alternative pathway	CFH CFHR4	1.62e-04	7	58	2	GO:0030451
GeneOntologyBiologicalProcess	inflammatory response to wounding	CFH TIMP1 CFHR4	1.66e-04	38	58	3	GO:0090594
GeneOntologyBiologicalProcess	neural retina development	CFH GDF11 CRB2 CFHR4	1.95e-04	102	58	4	GO:0003407
GeneOntologyBiologicalProcess	monocyte aggregation	CFH CFHR4	2.76e-04	9	58	2	GO:0070487
GeneOntologyBiologicalProcess	immune complex clearance	CFH CFHR4	2.76e-04	9	58	2	GO:0002434
GeneOntologyBiologicalProcess	humoral immune response	CFH CFHR1 CD55 C4BPB CFHR4 CFHR3	2.78e-04	321	58	6	GO:0006959
GeneOntologyBiologicalProcess	regulation of complement activation, classical pathway	CD55 C4BPB	3.45e-04	10	58	2	GO:0030450
GeneOntologyBiologicalProcess	retinal pigment epithelium development	CFH CFHR4	3.45e-04	10	58	2	GO:0003406
GeneOntologyBiologicalProcess	camera-type eye photoreceptor cell differentiation	CFH CRB2 CFHR4	3.55e-04	49	58	3	GO:0060219
GeneOntologyBiologicalProcess	eye photoreceptor cell development	CFH CRB2 CFHR4	4.23e-04	52	58	3	GO:0042462
GeneOntologyBiologicalProcess	organ or tissue specific immune response	CFH C17orf99 CFHR4	4.73e-04	54	58	3	GO:0002251
GeneOntologyBiologicalProcess	immunoglobulin mediated immune response	CFH C17orf99 CD55 C4BPB CFHR4	5.16e-04	235	58	5	GO:0016064
GeneOntologyBiologicalProcess	kidney development	CFH JAG1 ITGA3 GDF11 SMAD3 CFHR4	6.07e-04	372	58	6	GO:0001822
GeneOntologyBiologicalProcess	B cell mediated immunity	CFH C17orf99 CD55 C4BPB CFHR4	6.11e-04	244	58	5	GO:0019724
GeneOntologyBiologicalProcess	activin receptor signaling pathway	IGSF1 GDF11 SMAD3	6.44e-04	60	58	3	GO:0032924
GeneOntologyBiologicalProcess	female pregnancy	CEACAM21 TIMP1 ITGA3 ARID1A CDH1	6.70e-04	249	58	5	GO:0007565
GeneOntologyBiologicalProcess	epithelium development	CFH MYF6 JAG1 PAX4 ARID1A CDH1 GDF11 IQGAP3 S1PR3 CRB2 SMAD3 CFHR4	6.75e-04	1469	58	12	GO:0060429
GeneOntologyBiologicalProcess	negative regulation of complement activation	CD55 C4BPB	6.92e-04	14	58	2	GO:0045916
GeneOntologyBiologicalProcess	negative regulation of cell differentiation	PRAMEF33 PRAMEF10 HDAC6 CDK12 JAG1 CDH1 GDF11 S1PR3 SMAD3	7.02e-04	875	58	9	GO:0045596
GeneOntologyBiologicalProcess	animal organ morphogenesis	CFH MYF6 GJB6 JAG1 PAX4 ARID1A CDH1 GDF11 CRB2 SMAD3 CFHR4	7.18e-04	1269	58	11	GO:0009887
GeneOntologyBiologicalProcess	renal system development	CFH JAG1 ITGA3 GDF11 SMAD3 CFHR4	7.36e-04	386	58	6	GO:0072001
GeneOntologyBiologicalProcess	positive regulation of epithelial to mesenchymal transition	JAG1 CRB2 SMAD3	7.43e-04	63	58	3	GO:0010718
GeneOntologyBiologicalProcess	negative regulation of endothelial cell differentiation	JAG1 S1PR3	7.97e-04	15	58	2	GO:0045602
GeneOntologyBiologicalProcess	regulation of immune response	CFH CFHR1 C17orf99 TNIP3 CD55 C4BPB IGSF1 SMAD3 CFHR4 CFHR3	8.10e-04	1085	58	10	GO:0050776
GeneOntologyBiologicalProcess	retinal rod cell development	CFH CFHR4	1.03e-03	17	58	2	GO:0046548
GeneOntologyBiologicalProcess	endocrine system development	PAX4 CDH1 GDF11 SMAD3	1.09e-03	161	58	4	GO:0035270
GeneOntologyBiologicalProcess	eye photoreceptor cell differentiation	CFH CRB2 CFHR4	1.10e-03	72	58	3	GO:0001754
GeneOntologyBiologicalProcess	photoreceptor cell development	CFH CRB2 CFHR4	1.14e-03	73	58	3	GO:0042461
GeneOntologyBiologicalProcess	columnar/cuboidal epithelial cell differentiation	JAG1 PAX4 CDH1 GDF11	1.17e-03	164	58	4	GO:0002065
GeneOntologyBiologicalProcess	somitogenesis	MYF6 CRB2 SMAD3	1.28e-03	76	58	3	GO:0001756
GeneOntologyBiologicalProcess	leukocyte aggregation	CFH CFHR4	1.29e-03	19	58	2	GO:0070486
GeneOntologyBiologicalProcess	complement activation, alternative pathway	CFH CFHR4	1.29e-03	19	58	2	GO:0006957
GeneOntologyBiologicalProcess	negative regulation of humoral immune response	CD55 C4BPB	1.29e-03	19	58	2	GO:0002921
GeneOntologyBiologicalProcess	multi-organism reproductive process	CEACAM21 TIMP1 ITGA3 ARID1A CDH1	1.32e-03	290	58	5	GO:0044703
GeneOntologyBiologicalProcess	glomerulus development	CFH JAG1 CFHR4	1.33e-03	77	58	3	GO:0032835
GeneOntologyBiologicalProcess	multi-multicellular organism process	CEACAM21 TIMP1 ITGA3 ARID1A CDH1	1.41e-03	294	58	5	GO:0044706
GeneOntologyBiologicalProcess	polyamine metabolic process	HDAC6 OAZ2	1.43e-03	20	58	2	GO:0006595
GeneOntologyBiologicalProcess	regulation of B cell mediated immunity	C17orf99 CD55 C4BPB	1.43e-03	79	58	3	GO:0002712
GeneOntologyBiologicalProcess	regulation of immunoglobulin mediated immune response	C17orf99 CD55 C4BPB	1.43e-03	79	58	3	GO:0002889
GeneOntologyBiologicalProcess	nephron development	CFH JAG1 ITGA3 CFHR4	1.46e-03	174	58	4	GO:0072006
GeneOntologyBiologicalProcess	lymphocyte mediated immunity	CFH C17orf99 JAG1 CD55 C4BPB CFHR4	1.60e-03	449	58	6	GO:0002449
GeneOntologyCellularComponent	symbiont cell surface	CFH CFHR4	2.17e-04	8	59	2	GO:0106139
GeneOntologyCellularComponent	other organism part	CFH CFHR4	2.78e-04	9	59	2	GO:0044217
GeneOntologyCellularComponent	flotillin complex	CORO1C CDH1	3.47e-04	10	59	2	GO:0016600
HumanPheno	Decreased circulating complement factor H concentration	CFH CFHR1 CFHR3	1.48e-07	4	18	3	HP:0005369
HumanPheno	Decreased circulating complement factor I concentration	CFH CFHR1 CFHR3	3.69e-07	5	18	3	HP:0005356
HumanPheno	Decreased circulating complement factor B concentration	CFH CFHR1 CFHR3	3.69e-07	5	18	3	HP:0005416
HumanPheno	Macular hemorrhage	CFH CFHR1 CFHR3	1.29e-06	7	18	3	HP:0025574
HumanPheno	Macular drusen	CFH CFHR1 CFHR3	2.05e-06	8	18	3	HP:0030499
HumanPheno	Anuria	CFH CFHR1 CFHR3	1.04e-05	13	18	3	HP:0100519
HumanPheno	Schistocytosis	CFH CFHR1 CFHR3	1.04e-05	13	18	3	HP:0001981
HumanPheno	Microangiopathic hemolytic anemia	CFH CFHR1 CFHR3	1.32e-05	14	18	3	HP:0001937
HumanPheno	Hemolytic-uremic syndrome	CFH CFHR1 CFHR3	2.44e-05	17	18	3	HP:0005575
HumanPheno	Yellow/white lesions of the macula	CFH CFHR1 CFHR3	3.47e-05	19	18	3	HP:0030500
HumanPheno	Increased blood urea nitrogen	CFH CFHR1 CFHR3	6.28e-05	23	18	3	HP:0003138
HumanPheno	Choroidal neovascularization	CFH CFHR1 CFHR3	6.28e-05	23	18	3	HP:0011506
HumanPheno	Foveal hypopigmentation	CFHR1 CFHR3	7.05e-05	4	18	2	HP:0012643
HumanPheno	Abnormal blood urea nitrogen concentration	CFH CFHR1 CFHR3	8.12e-05	25	18	3	HP:0031970
HumanPheno	Abnormal urine output	CFH CFHR1 PAX4 CFHR3	8.18e-05	69	18	4	HP:0012590
HumanPheno	Abnormality of renal excretion	CFH CFHR1 PAX4 CFHR3	1.13e-04	75	18	4	HP:0011036
HumanPheno	Abnormal morphology of the choroidal vasculature	CFH CFHR1 CFHR3	1.15e-04	28	18	3	HP:0025568
HumanPheno	Drusen	CFH CFHR1 CFHR3	1.28e-04	29	18	3	HP:0011510
HumanPheno	Fundus hemorrhage	CFH CFHR1 CFHR3	1.42e-04	30	18	3	HP:0031803
HumanPheno	Decreased urine output	CFH CFHR1 CFHR3	1.42e-04	30	18	3	HP:0011037
HumanPheno	Retinal hemorrhage	CFH CFHR1 CFHR3	1.42e-04	30	18	3	HP:0000573
HumanPheno	Geographic atrophy	CFHR1 CFHR3	2.45e-04	7	18	2	HP:0031609
HumanPheno	Clubbing of fingers	GJB6 JAG1 CD55	3.13e-04	39	18	3	HP:0100759
HumanPheno	Abnormality of foveal pigmentation	CFHR1 CFHR3	3.26e-04	8	18	2	HP:0030493
HumanPheno	Decreased circulating complement C3 concentration	CFH CFHR1 CFHR3	4.19e-04	43	18	3	HP:0005421
HumanPheno	Acute kidney injury	CFH CFHR1 CFHR3	4.48e-04	44	18	3	HP:0001919
HumanPheno	Reticulocytosis	CFH CFHR1 CFHR3	5.45e-04	47	18	3	HP:0001923
HumanPheno	Abnormality of macular pigmentation	CFH CFHR1 CFHR3	5.45e-04	47	18	3	HP:0008002
HumanPheno	Elevated circulating creatinine concentration	CFH CFHR1 CFHR3	7.35e-04	52	18	3	HP:0003259
HumanPheno	Hemorrhage of the eye	CFH CFHR1 CFHR3	7.77e-04	53	18	3	HP:0011885
MousePheno	white pupil	CFH CFHR4	1.01e-05	2	45	2	MP:0006242
MousePheno	decreased serum complement activity	CFH CFHR4	1.01e-05	2	45	2	MP:0012553
MousePheno	artery occlusion	CFH CFHR4	1.01e-05	2	45	2	MP:0006134
MousePheno	decreased complement C5 level	CFH CFHR4	1.01e-05	2	45	2	MP:0012609
MousePheno	abnormal complement C5 level	CFH CFHR4	1.01e-05	2	45	2	MP:0012608
MousePheno	abnormal hepatic portal vein thrombosis	CFH CFHR4	1.01e-05	2	45	2	MP:0031159
MousePheno	abnormal renal glomerulus basement membrane morphology	CFH ITGA3 SMAD3 CFHR4	1.16e-05	44	45	4	MP:0011348
MousePheno	increased susceptilbility to retina ischemic injury	CFH CFHR4	3.03e-05	3	45	2	MP:0012049
MousePheno	abnormal kidney venous thrombosis	CFH CFHR4	3.03e-05	3	45	2	MP:0031161
MousePheno	abnormal response to retina ischemic injury	CFH CFHR4	6.05e-05	4	45	2	MP:0012048
MousePheno	increased susceptibility to type III hypersensitivity reaction	CFH CFHR4	6.05e-05	4	45	2	MP:0005615
MousePheno	decreased circulating complement protein level	CFH CFHR4	6.05e-05	4	45	2	MP:0020216
MousePheno	mesangial cell interposition	CFH CFHR4	6.05e-05	4	45	2	MP:0011512
MousePheno	abnormal brain thrombosis	CFH CFHR4	6.05e-05	4	45	2	MP:0031168
MousePheno	increased creatine level	CFH CFHR4	6.05e-05	4	45	2	MP:0010061
MousePheno	abnormal complement pathway	CFH CD55 CFHR4	7.70e-05	26	45	3	MP:0002471
MousePheno	abnormal venous thrombosis	CFH CFHR4	1.01e-04	5	45	2	MP:0031158
MousePheno	abnormal lung thrombosis	CFH CFHR4	1.01e-04	5	45	2	MP:0031167
MousePheno	abnormal circulating complement protein level	CFH CFHR4	1.51e-04	6	45	2	MP:0010215
MousePheno	abnormal glomerular capillary thrombosis	CFH CFHR4	2.11e-04	7	45	2	MP:0011508
MousePheno	brain ischemia	CFH CFHR4	2.80e-04	8	45	2	MP:0006080
MousePheno	abnormal complement protein level	CFH CFHR4	3.60e-04	9	45	2	MP:0011566
MousePheno	abnormal creatine level	CFH CFHR4	3.60e-04	9	45	2	MP:0010060
MousePheno	abnormal type III hypersensitivity reaction	CFH CFHR4	4.49e-04	10	45	2	MP:0002533
MousePheno	abnormal kidney thrombosis	CFH CFHR4	4.49e-04	10	45	2	MP:0011507
MousePheno	abnormal glomerular capillary morphology	CFH ITGA3 CFHR4	4.58e-04	47	45	3	MP:0011320
MousePheno	abnormal kidney capillary morphology	CFH ITGA3 CFHR4	4.87e-04	48	45	3	MP:0011310
MousePheno	abnormal mesangial matrix morphology	CFH SMAD3 CFHR4	5.83e-04	51	45	3	MP:0011338
MousePheno	abnormal synovial joint morphology	MYF6 ARSB GDF11 SMAD3	6.63e-04	124	45	4	MP:0030804
MousePheno	abnormal visual acuity	CFH CFHR4	7.73e-04	13	45	2	MP:0011832
MousePheno	decreased visual acuity	CFH CFHR4	7.73e-04	13	45	2	MP:0006149
MousePheno	abnormal articular cartilage morphology	ARSB SMAD3	9.00e-04	14	45	2	MP:0006433
MousePheno	abnormal Bruch membrane morphology	CFH CFHR4	9.00e-04	14	45	2	MP:0005239
MousePheno	retina detachment	CFH CFHR4	1.04e-03	15	45	2	MP:0003099
MousePheno	albuminuria	CFH CD55 CFHR4	1.08e-03	63	45	3	MP:0002871
MousePheno	abnormal placenta morphology	CDK12 WDCP ITGA3 ARID1A CDH1 CRB2 ZNF503	1.33e-03	525	45	7	MP:0001711
MousePheno	amyloid beta deposits	CFH CFHR4	1.34e-03	17	45	2	MP:0003329
MousePheno	abnormal rib morphology	MYF6 ARSB CORO1C GDF11 SMAD3	1.35e-03	257	45	5	MP:0000150
Domain	Sushi	CFH CFHR1 CD55 C4BPB CFHR4 CFHR3	9.03e-09	52	55	6	PF00084
Domain	CCP	CFH CFHR1 CD55 C4BPB CFHR4 CFHR3	1.14e-08	54	55	6	SM00032
Domain	SUSHI	CFH CFHR1 CD55 C4BPB CFHR4 CFHR3	1.43e-08	56	55	6	PS50923
Domain	Sushi_SCR_CCP_dom	CFH CFHR1 CD55 C4BPB CFHR4 CFHR3	1.59e-08	57	55	6	IPR000436
Domain	Keratin_matx	KRTAP3-3 KRTAP3-2	2.55e-05	3	55	2	PF04579
Domain	Keratin_matx	KRTAP3-3 KRTAP3-2	5.09e-05	4	55	2	PD010562
Domain	hEGF	JAG1 FBN3 CRB2	7.51e-05	28	55	3	PF12661
Domain	Keratin_matx	KRTAP3-3 KRTAP3-2	8.47e-05	5	55	2	IPR007659
Domain	EGF	ZAN JAG1 FBN3 CRB2	5.16e-04	126	55	4	PF00008
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_CFHR	CFH CFHR1 CFHR4 CFHR3	4.76e-10	6	35	4	M47880
Pathway	REACTOME_COMPLEMENT_CASCADE	CFH CFHR1 CD55 C4BPB CFHR4 CFHR3	3.46e-07	115	35	6	M19752
Pathway	REACTOME_COMPLEMENT_CASCADE	CFH CFHR1 CD55 CFHR4	5.34e-05	84	35	4	MM14653
Pathway	KEGG_MEDICUS_REFERENCE_ALTERNATIVE_PATHWAY_OF_COMPLEMENT_CASCADE_C3B_BREAKDOWN	CFH CD55	5.96e-05	5	35	2	M47875
Pathway	WP_COMPLEMENT_SYSTEM_IN_NEURONAL_DEVELOPMENT_AND_PLASTICITY	CFH CD55 C4BPB CRB2	1.32e-04	106	35	4	M42535
Pathway	REACTOME_SIGNALING_BY_TGFBR3	MYF6 TIMP1 SMAD3	2.39e-04	49	35	3	M48250
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	ADAMTS4 TIMP1 CDH1 FBN3	3.84e-04	140	35	4	M587
Pathway	KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	CFH CD55 C4BPB	6.57e-04	69	35	3	M16894
Pathway	WP_H19_RBE2F1_AND_CDKBETACATENIN_IN_COLORECTAL_CANCER	JAG1 CDH1	7.03e-04	16	35	2	M39472
Pathway	BIOCARTA_TGFB_PATHWAY	CDH1 SMAD3	7.96e-04	17	35	2	MM1509
Pathway	REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM	CDH1 SMAD3	7.96e-04	17	35	2	M48030
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	ADAMTS4 TIMP1 ITGA3 CDH1 FBN3	8.12e-04	300	35	5	M610
Pathway	WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION	CDH1 SMAD3	9.97e-04	19	35	2	M39370
Pathway	BIOCARTA_TGFB_PATHWAY	CDH1 SMAD3	9.97e-04	19	35	2	M18933
Pubmed	CFH and CFHR structural variants in atypical Hemolytic Uremic Syndrome: Prevalence, genomic characterization and impact on outcome.	CFH CFHR1 CFHR4 CFHR3	7.47e-12	4	59	4	36793547
Pubmed	Identification and sequence analysis of four complement factor H-related transcripts in mouse liver.	CFH CFHR1 CFHR4 CFHR3	3.73e-11	5	59	4	1689298
Pubmed	A radiation hybrid map of complement factor H and factor H-related genes.	CFH CFHR1 CFHR4 CFHR3	3.73e-11	5	59	4	10380701
Pubmed	Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk.	CFH CFHR1 CFHR4 CFHR3	1.12e-10	6	59	4	27196323
Pubmed	Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications.	CFH CFHR1 CFHR4 CFHR3	1.12e-10	6	59	4	17438673
Pubmed	Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome.	CFH CFHR1 CFHR4 CFHR3	2.60e-10	7	59	4	19861685
Pubmed	Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome.	CFH CFHR1 CFHR4 CFHR3	9.35e-10	9	59	4	20059470
Pubmed	FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.	CFH CFHR1 CFHR4 CFHR3	9.35e-10	9	59	4	28533443
Pubmed	Genetic Atypical Hemolytic-Uremic Syndrome	CFH CFHR1 CFHR4 CFHR3	2.44e-09	11	59	4	20301541
Pubmed	Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes.	CFH CFHR1 CFHR3	4.64e-09	3	59	3	10781834
Pubmed	Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy.	CFH CFHR1 CFHR3	4.64e-09	3	59	3	25205734
Pubmed	Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency.	CFH CFHR1 CFHR3	4.64e-09	3	59	3	18006700
Pubmed	Evaluation of CFH Y402H polymorphism and CFHR3/CFHR1 deletion in age-related macular degeneration patients from Brazil.	CFH CFHR1 CFHR3	4.64e-09	3	59	3	26942649
Pubmed	An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD).	CFH CFHR1 CFHR3	4.64e-09	3	59	3	20843825
Pubmed	A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes.	CFH CFHR1 CFHR3	4.64e-09	3	59	3	32321835
Pubmed	Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.	CFHR1 CFHR4 CFHR3	4.64e-09	3	59	3	21637784
Pubmed	Associations of CFHR1-CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent.	CFH CFHR1 CFHR3	4.64e-09	3	59	3	20581873
Pubmed	Complement factor H, FHR-3 and FHR-1 variants associate in an extended haplotype conferring increased risk of atypical hemolytic uremic syndrome.	CFH CFHR1 CFHR3	4.64e-09	3	59	3	26163426
Pubmed	Association assessment of copy number polymorphism and risk of age-related macular degeneration.	CFH CFHR1 CFHR3	4.64e-09	3	59	3	21856016
Pubmed	Atypical hemolytic uremic syndrome associated with complement factor H autoantibodies and CFHR1/CFHR3 deficiency.	CFH CFHR1 CFHR3	4.64e-09	3	59	3	19531976
Pubmed	Associations of CFH polymorphisms and CFHR1-CFHR3 deletion with blood pressure and hypertension in Chinese population.	CFH CFHR1 CFHR3	4.64e-09	3	59	3	22848687
Pubmed	Two factor H-related proteins from the mouse: expression analysis and functional characterization.	CFH CFHR4 CFHR3	4.64e-09	3	59	3	17028856
Pubmed	Localization of complement factor H gene expression and protein distribution in the mouse outer retina.	CFH CFHR4 CFHR3	4.64e-09	3	59	3	25684976
Pubmed	Atypical haemolytic-uraemic syndrome due to heterozygous mutations of CFH/CFHR1-3 and complement factor H 479.	CFH CFHR1 CFHR3	1.85e-08	4	59	3	24333077
Pubmed	Genome-wide association study identifies susceptibility loci for IgA nephropathy.	CFH CFHR1 CFHR4 CFHR3	2.84e-08	19	59	4	21399633
Pubmed	Factor H-related proteins determine complement-activating surfaces.	CFHR1 CFHR4 CFHR3	4.63e-08	5	59	3	25979655
Pubmed	Complement factor H and related proteins: an expanding family of complement-regulatory proteins?	CFH CFHR1 CFHR3	4.63e-08	5	59	3	8172644
Pubmed	Molecular basis of C-reactive protein binding and modulation of complement activation by factor H-related protein 4.	CFH CFHR4 CFHR3	4.63e-08	5	59	3	20042240
Pubmed	Dimerization of complement factor H-related proteins modulates complement activation in vivo.	CFH CFHR1 CFHR4	9.24e-08	6	59	3	23487775
Pubmed	Growth of geographic atrophy on fundus autofluorescence and polymorphisms of CFH, CFB, C3, FHR1-3, and ARMS2 in age-related macular degeneration.	CFH CFHR1 CFHR3	9.24e-08	6	59	3	24557084
Pubmed	Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation.	CFH CD55 CFHR4	1.62e-07	7	59	3	28057640
Pubmed	The regulation of the complement system: insights from genetically-engineered mice.	CFH CD55 CFHR4	1.62e-07	7	59	3	12914820
Pubmed	Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.	CFH CFHR1 CD55 C4BPB	2.27e-07	31	59	4	19344414
Pubmed	Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury.	CFH CD55 CFHR4	3.87e-07	9	59	3	18947875
Pubmed	Circulating AIM prevents hepatocellular carcinoma through complement activation.	CFH CD55 CFHR4	5.52e-07	10	59	3	25284781
Pubmed	Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis.	CFH CD55 CFHR4	7.58e-07	11	59	3	23204401
Pubmed	Complement factor H, a marker of self protects against experimental autoimmune encephalomyelitis.	CFH CD55 CFHR4	1.67e-06	14	59	3	19299737
Pubmed	Integrin β1 Establishes Liver Microstructure and Modulates Transforming Growth Factor β during Liver Development and Regeneration.	TIMP1 CDH1 SMAD3	1.67e-06	14	59	3	33159885
Pubmed	Genetic influences on the end-stage effector phase of arthritis.	CFH CD55 CFHR4	2.56e-06	16	59	3	11489951
Pubmed	Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression.	JAG1 ITGA3 CDH1	2.56e-06	16	59	3	17021047
Pubmed	Deletion Variants of CFHR1 and CFHR3 Associate with Mesangial Immune Deposits but Not with Progression of IgA Nephropathy.	CFHR1 CFHR3	2.83e-06	2	59	2	29114042
Pubmed	Absence of complement factor H reduces physical performance in C57BL6 mice.	CFH CFHR4	2.83e-06	2	59	2	32962822
Pubmed	Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings.	CFH CFHR4	2.83e-06	2	59	2	20538999
Pubmed	Inheritance, hormonal regulation and properties of polymorphic murine antigens Mud1 and Mud2.	CFH CFHR4	2.83e-06	2	59	2	4992636
Pubmed	Retinal changes precede visual dysfunction in the complement factor H knockout mouse.	CFH CFHR4	2.83e-06	2	59	2	23844226
Pubmed	Partial Complement Factor H Deficiency Associates with C3 Glomerulopathy and Thrombotic Microangiopathy.	CFH CFHR4	2.83e-06	2	59	2	26374608
Pubmed	A gene locus concerned with an antigenic serum substance in Mus musculus.	CFH CFHR4	2.83e-06	2	59	2	4955525
Pubmed	Analysis of complement factor H mRNA expression: dexamethasone and IFN-gamma increase the level of H in L cells.	CFH CFHR4	2.83e-06	2	59	2	2533512
Pubmed	Complement factor H: spatial and temporal expression and localization in the eye.	CFH CFHR4	2.83e-06	2	59	2	16936129
Pubmed	Watching synchronous mitochondrial respiration in the retina and its instability in a mouse model of macular degeneration.	CFH CFHR4	2.83e-06	2	59	2	33558624
Pubmed	ARID1A-deficient cells require HDAC6 for progression of endometrial carcinoma.	HDAC6 ARID1A	2.83e-06	2	59	2	35167193
Pubmed	A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration.	CFHR1 CFHR3	2.83e-06	2	59	2	16998489
Pubmed	Complement factor H Y402H polymorphism results in diminishing CD4+ T cells and increasing C-reactive protein in plasma.	CFH CFHR4	2.83e-06	2	59	2	37940659
Pubmed	Comparative analysis of the properties and ligand binding characteristics of CspZ, a factor H binding protein, derived from Borrelia burgdorferi isolates of human origin.	CFH CFHR4	2.83e-06	2	59	2	19620346
Pubmed	Copy number variation in the complement factor H-related genes and age-related macular degeneration.	CFHR1 CFHR3	2.83e-06	2	59	2	21850184
Pubmed	Factor H and CFHR1 polymorphisms associated with atypical Haemolytic Uraemic Syndrome (aHUS) are differently expressed in Tunisian and in Caucasian populations.	CFH CFHR1	2.83e-06	2	59	2	22136554
Pubmed	Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration.	CFH CFHR4	2.83e-06	2	59	2	30705315
Pubmed	Deciphering the ligand-binding sites in the Borrelia burgdorferi complement regulator-acquiring surface protein 2 required for interactions with the human immune regulators factor H and factor H-like protein 1.	CFH CFHR1	2.83e-06	2	59	2	18824548
Pubmed	Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease.	CFH CFHR3	2.83e-06	2	59	2	20694013
Pubmed	A complement factor H homolog, heparan sulfation, and syndecan maintain inversin compartment boundaries in C. elegans cilia.	CFH CFHR4	2.83e-06	2	59	2	33859044
Pubmed	Regulation of age-related macular degeneration-like pathology by complement factor H.	CFH CFHR4	2.83e-06	2	59	2	25991857
Pubmed	Prompt plasma exchanges and immunosuppressive treatment improves the outcomes of anti-factor H autoantibody-associated hemolytic uremic syndrome in children.	CFHR1 CFHR3	2.83e-06	2	59	2	24088957
Pubmed	Anti-factor H autoantibody-associated hemolytic uremic syndrome: review of literature of the autoimmune form of HUS.	CFH CFHR1	2.83e-06	2	59	2	20865640
Pubmed	A synthetic protein as efficient multitarget regulator against complement over-activation.	CFH CFHR1	2.83e-06	2	59	2	35194132
Pubmed	Serological survey of complement factor H in common laboratory and wild mice: a new third allotype.	CFH CFHR4	2.83e-06	2	59	2	2522412
Pubmed	Absence of complement factor H alters bone architecture and dynamics.	CFH CFHR4	2.83e-06	2	59	2	30107932
Pubmed	Complement factor H-related protein 1 deficiency and factor H antibodies in pediatric patients with atypical hemolytic uremic syndrome.	CFH CFHR1	2.83e-06	2	59	2	23243267
Pubmed	Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice.	CFH CFHR4	2.83e-06	2	59	2	34054871
Pubmed	Factor H binding to PspC of Streptococcus pneumoniae increases adherence to human cell lines in vitro and enhances invasion of mouse lungs in vivo.	CFH CFHR4	2.83e-06	2	59	2	17562771
Pubmed	Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology.	CFH CFHR4	2.83e-06	2	59	2	27397653
Pubmed	ARID1A regulates E-cadherin expression in colorectal cancer cells: a promising candidate therapeutic target.	ARID1A CDH1	2.83e-06	2	59	2	34424445
Pubmed	Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration.	CFH CFHR4	2.83e-06	2	59	2	29392311
Pubmed	Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150-kDa molecule.	CFH CFHR1	2.83e-06	2	59	2	1826708
Pubmed	The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation.	CFH CFHR4	2.83e-06	2	59	2	22174452
Pubmed	Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids.	CFH CFHR4	2.83e-06	2	59	2	22875704
Pubmed	Local complement factor H protects kidney endothelial cell structure and function.	CFH CFHR4	2.83e-06	2	59	2	34139209
Pubmed	Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis.	CFH CFHR4	2.83e-06	2	59	2	32849636
Pubmed	Complement factor h is critical in the maintenance of retinal perfusion.	CFH CFHR4	2.83e-06	2	59	2	19541934
Pubmed	Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction.	CFH CFHR4	2.83e-06	2	59	2	17921253
Pubmed	The role of complement dysregulation in AMD mouse models.	CFH CFHR4	2.83e-06	2	59	2	24664701
Pubmed	Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light.	CFH CFHR4	2.83e-06	2	59	2	26149919
Pubmed	Murine protein H is comprised of 20 repeating units, 61 amino acids in length.	CFH CFHR4	2.83e-06	2	59	2	2940596
Pubmed	A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies.	CFH CFHR4	2.83e-06	2	59	2	32165615
Pubmed	Human complement factor H and factor H-like protein 1 are expressed in human retinal pigment epithelial cells.	CFH CFHR1	2.83e-06	2	59	2	24280833
Pubmed	Death by color: differential cone loss in the aging mouse retina.	CFH CFHR4	2.83e-06	2	59	2	24929970
Pubmed	A novel hybrid CFHR1/CFH gene causes atypical hemolytic uremic syndrome.	CFH CFHR1	2.83e-06	2	59	2	23880784
Pubmed	Binding of the human complement regulators CFHR1 and factor H by streptococcal collagen-like protein 1 (Scl1) via their conserved C termini allows control of the complement cascade at multiple levels.	CFH CFHR1	2.83e-06	2	59	2	20855886
Pubmed	Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis.	CFH CFHR4	2.83e-06	2	59	2	23436934
Pubmed	Fine Mapping Implicates a Deletion of CFHR1 and CFHR3 in Protection from IgA Nephropathy in Han Chinese.	CFHR1 CFHR3	2.83e-06	2	59	2	26940089
Pubmed	Treatment with 670 nm light up regulates cytochrome C oxidase expression and reduces inflammation in an age-related macular degeneration model.	CFH CFHR4	2.83e-06	2	59	2	23469078
Pubmed	Complement factor h limits immune complex deposition and prevents inflammation and scarring in glomeruli of mice with chronic serum sickness.	CFH CFHR4	2.83e-06	2	59	2	15574507
Pubmed	Complement factor H: a biomarker for progression of cutaneous squamous cell carcinoma.	CFH CFHR1	2.83e-06	2	59	2	23938460
Pubmed	Design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules.	CFH CFHR4	2.83e-06	2	59	2	23133374
Pubmed	TIMP-1 expression in human colorectal cancer is associated with SMAD3 gene expression levels: a pilot study.	TIMP1 SMAD3	2.83e-06	2	59	2	25532000
Pubmed	The absence of CFHR3 and CFHR1 genes from the T2T-CHM13 assembly can limit the molecular diagnosis of complement-related diseases.	CFHR1 CFHR3	2.83e-06	2	59	2	37032353
Pubmed	Location of the mouse complement factor H gene (cfh) by FISH analysis and replication R-banding.	CFH CFHR4	2.83e-06	2	59	2	1486806
Pubmed	Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains.	CFH CFHR4	2.83e-06	2	59	2	17517971
Pubmed	Treatment with human complement factor H rapidly reverses renal complement deposition in factor H-deficient mice.	CFH CFHR4	2.83e-06	2	59	2	20445496
Pubmed	High-density lipoproteins are a potential therapeutic target for age-related macular degeneration.	CFH CFHR4	2.83e-06	2	59	2	32737203
Pubmed	CFH-CFHR1 hybrid genes in two cases of atypical hemolytic uremic syndrome.	CFH CFHR1	2.83e-06	2	59	2	36755127
Interaction	PLSCR3 interactions	KRTAP3-3 KRTAP3-2 TNIP3 CDH1	1.02e-05	48	57	4	int:PLSCR3
Cytoband	1q32	CFH CFHR1 CD55 C4BPB CFHR4 CFHR3	4.65e-11	49	59	6	1q32
Cytoband	Ensembl 112 genes in cytogenetic band chr1q31	CFH CFHR1 CFHR4 CFHR3	2.79e-06	75	59	4	chr1q31
Cytoband	17q12-q21	KRTAP3-3 KRTAP3-2	7.86e-04	32	59	2	17q12-q21
Cytoband	1p36.21	PRAMEF33 PRAMEF10	3.02e-03	63	59	2	1p36.21
Cytoband	Ensembl 112 genes in cytogenetic band chr17q21	KRTAP3-3 KRTAP3-2 ITGA3 FAM187A	3.24e-03	473	59	4	chr17q21
Cytoband	Ensembl 112 genes in cytogenetic band chr1q22	GON4L IQGAP3	3.81e-03	71	59	2	chr1q22
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFH CFHR1 CD55 C4BPB CFHR4 CFHR3	3.09e-09	57	41	6	1179
GeneFamily	Complement system\|Sushi domain containing	CFH CFHR1 CFHR4 CFHR3	1.27e-06	36	41	4	492
Coexpression	SU_LIVER	CFHR1 C4BPB ARID1A CFHR4	8.97e-06	58	59	4	M7054
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYOM1 ADAMTS4 TRARG1 JAG1 OAZ2	3.08e-06	170	59	5	d9ed257d0938442d0bb280e4c4b0c9b657511b46
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-8\|TCGA-Liver / Sample_Type by Project: Shred V9	CFH PRAMEF33 PRAMEF10 CFHR4 CFHR3	3.17e-06	171	59	5	c4a919fe3d56ae6df2fcab6686abacc10befc053
ToppCell	TCGA-Colorectal-Recurrent_Tumor\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CFHR1 PRAMEF33 PRAMEF10 CFHR4 CFHR3	3.55e-06	175	59	5	7f74961436f88c0e380819095e6104489914d765
ToppCell	TCGA-Colorectal-Recurrent_Tumor-Colorectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CFHR1 PRAMEF33 PRAMEF10 CFHR4 CFHR3	3.55e-06	175	59	5	bee8f31f036dfcf9fc6ed29156554771a9ee3c60
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH GJB6 C4BPB ITGA3 CRB2	4.19e-06	181	59	5	3dcb74b28f93be35ddf4de1937f7e30b25e11927
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH GJB6 C4BPB ITGA3 CRB2	4.19e-06	181	59	5	7679a5980011d6dfb1aaca7abf678c29b6f819bb
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TNIP3 CD55 ITGA3 CDH1 FBN3	4.53e-06	184	59	5	29c95b814a0b1ad8734ed68b77df29c08594e5ec
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)\|343B / Donor, Lineage, Cell class and subclass (all cells)	CD55 C4BPB ITGA3 CDH1 FBN3	4.53e-06	184	59	5	cb15d6bae52c5ec251c2235859dc7e65f630ae23
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	CD55 C4BPB ITGA3 CDH1 FBN3	4.53e-06	184	59	5	bde4eaabd3e9bdaed23867d23a919b9d84b52d4b
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYOM1 ADAMTS4 TRARG1 GDF11 S1PR3	5.04e-06	188	59	5	a5e7a363fbd5ae4d9312cf6f9941413d6a5c0b4d
ToppCell	droplet-Limb_Muscle-nan-24m-Mesenchymal-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYF6 MYOM1 ADAMTS4 TRARG1 S1PR3	5.87e-06	194	59	5	fb234d97191c95b7880280c6e4ed5df124ffb0e1
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38\|World / Primary Cells by Cluster	CORO1C TMEM158 EML6 RSF1 CHD9	6.17e-06	196	59	5	38da0751941adca650fe9b383d9f343153978eb5
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn\|World / Primary Cells by Cluster	CORO1C TMEM158 EML6 RSF1 CHD9	6.17e-06	196	59	5	721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-stromal_related\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH CFHR1 TIMP1 S1PR3 CRB2	6.32e-06	197	59	5	ea9332adf753d7e92f89654320543abb9e6142aa
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-stromal_related-T_reticular\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH CFHR1 TIMP1 S1PR3 CRB2	6.48e-06	198	59	5	11f21a4a97da10fc6ae604cb627aa3af749d9dff
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Hs3st6\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CFH TCAF2 CDH1 ZNF503	2.15e-05	123	59	4	64a2d7e40d9c948a9ccaf61c465fb2207e0b7ab8
ToppCell	10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-MAIT\|GI_small-bowel / Manually curated celltypes from each tissue	CFH CFHR1 CFHR4 CFHR3	4.22e-05	146	59	4	1cb2e157222631e8915d89b255a843d16d7d99cc
ToppCell	Frontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MYOM1 TRARG1 C11orf16 S1PR3	4.81e-05	151	59	4	527059e47e381b2f6d63c1abb39bc0795ee3829d
ToppCell	Frontal_cortex-Endothelial-MURAL\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MYOM1 TRARG1 C11orf16 S1PR3	4.81e-05	151	59	4	7570372a315bc312ff57bb5f483375c401ae8787
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Ntng1_(Entopeduncular_Nucleus_(Ent)_or_Zona_Incerta,_ventral_part_(ZIV)._State_signal?)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ZAN P2RX6 CDH1	5.65e-05	56	59	3	ad76712e6a99072f9c6dab6d746db54f754e14fd
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Ntng1_(Entopeduncular_Nucleus_(Ent)_or_Zona_Incerta,_ventral_part_(ZIV)._State_signal?)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ZAN P2RX6 CDH1	5.65e-05	56	59	3	20a2977f41d3ecbc4fbee7ecd6dfb4b7ce0e4bb7
ToppCell	Posterior_cortex-Endothelial-MURAL\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MYOM1 TRARG1 C11orf16 S1PR3	7.44e-05	169	59	4	0ae65daf092396b71f790b65c7a2feed90397417
ToppCell	Posterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MYOM1 TRARG1 C11orf16 S1PR3	7.44e-05	169	59	4	8cd70ce27b1cecb83f8a376230e7ef41b079b124
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH CFHR1 P2RX6 S1PR3	7.97e-05	172	59	4	1ef243bce63d841c25e4b74d029d1377f84bcc3d
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH CFHR1 P2RX6 S1PR3	7.97e-05	172	59	4	ab1c81be29f93ca8920c6ab5ab92f497a9256d3f
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBCC\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TCAF2 TMEM158 TNIP3 CD55	8.33e-05	174	59	4	912a9e892b29d945666fc37c986009c97c668ac8
ToppCell	TCGA-Liver\|World / Sample_Type by Project: Shred V9	CFHR1 C4BPB CFHR4 CFHR3	8.33e-05	174	59	4	452932f08cf53e5949672a025d78cecb874aa4b0
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS4 TRARG1 S1PR3 MUTYH	9.29e-05	179	59	4	b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH C4BPB ITGA3 CRB2	9.29e-05	179	59	4	056df2aaff750e0e283e7da78fcc3c90c366aac0
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH C4BPB ITGA3 CRB2	9.29e-05	179	59	4	f5f3945ef3b9efc5921a71fd51deeb2c80f0ce11
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH TIMP1 TMEM158 S1PR3	9.50e-05	180	59	4	ea7a1ccf0dd3bb5af5df87501f873e7339a824b3
ToppCell	AT1_cells-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	CD55 C4BPB ITGA3 CDH1	9.50e-05	180	59	4	2d52cb5f77dde0e3dccac1333d4ec67ec680fcb2
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM158 JAG1 CD55 ZC3H12B	9.50e-05	180	59	4	67c5068b660cd5e727a665cefe3bd5f8ae887221
ToppCell	RA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	CFH TIMP1 SMAD3 CFHR3	9.70e-05	181	59	4	2b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH CFHR1 TIMP1 CRB2	9.70e-05	181	59	4	65eaa9bc1022bcf0c5f0f92c07a2cbbf11f9b59c
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(PRG4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH CFHR1 TIMP1 CRB2	9.70e-05	181	59	4	eaac7d58117eddfff06b25521efc431c1351d592
ToppCell	COVID-19-Epithelial_cells-ECM-high_epithelial\|COVID-19 / group, cell type (main and fine annotations)	TIMP1 CD55 ITGA3 CDH1	1.01e-04	183	59	4	dc1d380bf7564f290256cb7108063d1bd2da732b
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-Late_airway_progenitor\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CFH CFHR1 CDH1 FBN3	1.01e-04	183	59	4	0cea883a8a79fc58abcb26b08bf5db9d3d60f7d4
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 TRARG1 KRTAP3-3 JAG1	1.06e-04	185	59	4	5f5df92b328be396941b5812d00454b5ff927d30
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	P2RX6 GJB6 ITGA3 CRB2	1.06e-04	185	59	4	872720275789d249c9859de825a923803d458875
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 TRARG1 KRTAP3-3 JAG1	1.06e-04	185	59	4	98547c1b1828b76da810ed86082182afaaacdb3f
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH ADAMTS4 TIMP1 S1PR3	1.06e-04	185	59	4	e1fbec55b71f604189eb2431768fadbaa0453a83
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH ADAMTS4 TIMP1 S1PR3	1.06e-04	185	59	4	9d933cd5ebc8368fd37aa83113d2dfa6938ff72d
ToppCell	(5)_Pericytes\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	MYOM1 ADAMTS4 TRARG1 JAG1	1.08e-04	186	59	4	acbca8cc048d87faf859b3e77bdb38d0a3dad71c
ToppCell	(5)_Pericytes-(50)_Pericytes\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	MYOM1 ADAMTS4 TRARG1 JAG1	1.08e-04	186	59	4	67b59defdd1ed3608229cc5e2a3b480d92312afa
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TIMP1 JAG1 OAZ2 S1PR3	1.08e-04	186	59	4	db4d9ac89cc1e55062ba888b3410b773340595dd
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH TNIP3 CD55 C4BPB	1.08e-04	186	59	4	55fe25f4d0f2bc0fd4802a0a375169f2c41472fc
ToppCell	Epithelial-alveolar_epithelial_cell_type_1\|World / Lineage, Cell type, age group and donor	CD55 ITGA3 CDH1 FBN3	1.08e-04	186	59	4	09d95daa3387a4814cffaa4b798cc2810c3759d0
ToppCell	AT1_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	CD55 ITGA3 CDH1 FBN3	1.10e-04	187	59	4	f1dda349335e08dbfc8395d373924037f5ad2fd6
ToppCell	15-Trachea-Epithelial-Secretory_progenitor\|Trachea / Age, Tissue, Lineage and Cell class	CFH CFHR1 CD55 FBN3	1.10e-04	187	59	4	be9fce9e74b2f170a2067f1b31d802912a578329
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CD55 C4BPB CDH1 FBN3	1.10e-04	187	59	4	d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	P2RX6 JAG1 ITGA3 CRB2	1.10e-04	187	59	4	806075c2531a7f5c1da38b85ea494a3b4b5e92ec
ToppCell	wk_15-18-Mesenchymal-Mesothelial-Late_mesothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CFH TIMP1 ITGA3 CRB2	1.12e-04	188	59	4	38a53f99f1876359983936403aefca93281d10fd
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CD55 ITGA3 CDH1 FBN3	1.12e-04	188	59	4	eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH ITGA3 CDH1 CRB2	1.12e-04	188	59	4	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CD55 ITGA3 CDH1 SMAD3	1.12e-04	188	59	4	43a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH ITGA3 CDH1 CRB2	1.12e-04	188	59	4	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-muscle\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	CFH MYF6 TIMP1 IGSF1	1.12e-04	188	59	4	b01cb642f8b2d83235706fec7477c15005094161
ToppCell	droplet-Kidney-nan-3m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH MYOM1 TRARG1 S1PR3	1.15e-04	189	59	4	a959c9d6a0866582688a4204d625c1e5a123e93d
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH TIMP1 TMEM158 S1PR3	1.17e-04	190	59	4	8cb950effc449ae59a915132ecc079be54d1acfe
ToppCell	Fibroblasts-CD55+_Fibroblasts\|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	GJB6 EML6 CD55 ITGA3	1.17e-04	190	59	4	b4088128f5acf53f43244c9af9fe44e033f1a57a
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH TIMP1 TMEM158 S1PR3	1.17e-04	190	59	4	5dfbd064ab1f8a0b18b5975c47f8e79697f3db15
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH TIMP1 TMEM158 S1PR3	1.17e-04	190	59	4	17a73a658fb30a4322b31e38db7b240023738f29
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 ADAMTS4 TRARG1 S1PR3	1.17e-04	190	59	4	1ab3f19f1ce9f58e5125135704d94655a2e330a0
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFHR1 GJB6 ITGA3 CRB2	1.19e-04	191	59	4	5343a527de6b0f852f45020a91f5b4869e78f13a
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFHR1 GJB6 ITGA3 CRB2	1.19e-04	191	59	4	a25a5f9a380031fdaf57677a079f97a90f0550c0
ToppCell	droplet-Trachea-3m-Epithelial-airway_epithelial-neuroendocrine_cell-neuroendocrine\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYOM1 ADAMTS4 TRARG1 S1PR3	1.19e-04	191	59	4	72f1ddc09080dbfea8d51294cbf7f9d4925f9cc0
ToppCell	droplet-Trachea-3m-Epithelial-airway_epithelial-neuroendocrine_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYOM1 ADAMTS4 TRARG1 S1PR3	1.19e-04	191	59	4	6e7f589efc997f32175e0789c5ea7ca46e1389b8
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CD55 ITGA3 CDH1 FBN3	1.19e-04	191	59	4	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|World / Lineage, Cell type, age group and donor	CD55 ITGA3 CDH1 FBN3	1.19e-04	191	59	4	d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCell	droplet-Trachea-nan-3m-Epithelial-neuroendocrine_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 ADAMTS4 TRARG1 S1PR3	1.19e-04	191	59	4	3ce403e0beedb544edeb3ae6eb30267040d00c21
ToppCell	droplet-Kidney-nan-18m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH ADAMTS4 TIMP1 LRRN2	1.22e-04	192	59	4	38d7a24ae205ef91ed2e0f402d8022f2a9cdb243
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 TRARG1 C11orf16 S1PR3	1.22e-04	192	59	4	43228bddca2f606ddcae9731f04c6b1502c4b85a
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 TRARG1 C11orf16 S1PR3	1.22e-04	192	59	4	f5463c6bcc5c69ac562bec028f7a105c471f2fbe
ToppCell	MatrixFB-Fibroblast-D_(Pericyte)\|MatrixFB / shred on cell class and cell subclass (v4)	MYOM1 TRARG1 JAG1 OAZ2	1.22e-04	192	59	4	630444302511f511ec6976bc045a3b4b9d8d4547
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH TIMP1 P2RX6 CFHR3	1.22e-04	192	59	4	f88aba74d6e8c594c32fe2bc095b5da28b4b28e9
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Club\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CFH CFHR1 CDH1 CFHR4	1.22e-04	192	59	4	044c7ae56da17cacf2705efa8ac2c8aeba6cfeee
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH ADAMTS4 TIMP1 LRRN2	1.22e-04	192	59	4	04d155897ed075c359933080e36a4ab2150b6e9f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS4 CORO1C ITGA3 SMAD3	1.22e-04	192	59	4	8b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH TIMP1 P2RX6 CFHR3	1.22e-04	192	59	4	41a8326cd5bc19ad5041068501bab4c72399222e
ToppCell	droplet-Limb_Muscle-nan-18m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 ADAMTS4 TRARG1 S1PR3	1.22e-04	192	59	4	88472b99970ba0decbf87164fc241a1c77b3b389
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 TRARG1 C11orf16 S1PR3	1.22e-04	192	59	4	20fd69eb60b93d22d9be39de44b733db6d761dde
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH ADAMTS4 TIMP1 LRRN2	1.22e-04	192	59	4	84149a5c6c3b3c9b86aed77cf8e72d99ef099fab
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH MYOM1 TRARG1 S1PR3	1.22e-04	192	59	4	3617d2bc7e33d981f3ec349e9962d8d4bd822fbd
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH TIMP1 TMEM158 CRB2	1.24e-04	193	59	4	b05361ffe111a38cfa26eb86e4ae62c15ac99b7b
ToppCell	droplet-Limb_Muscle-nan-24m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 ADAMTS4 TRARG1 S1PR3	1.24e-04	193	59	4	b9e11cd0896c0868aab7faec4ab7ab4d4e4d1b47
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH CFHR1 TIMP1 S1PR3	1.24e-04	193	59	4	dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CFH TIMP1 ITGA3 CRB2	1.24e-04	193	59	4	a313541cedfcff8fb311b9bc60157359aa103830
ToppCell	LA-14._Fibroblast_III\|LA / Chamber and Cluster_Paper	CFH ADAMTS4 CD55 SMAD3	1.24e-04	193	59	4	7426c291bac59e539c427bcaae18abc7d397d44e
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 TRARG1 C11orf16 S1PR3	1.24e-04	193	59	4	7766f495f2f945802ef9a5b994cd00bb64d0dfe3
ToppCell	10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma-myofibroblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CFH CFHR1 MYF6 FBN3	1.24e-04	193	59	4	02dfd1df1e7fc84bfca2b0c95138b5b4408bb5d1
ToppCell	Fetal_29-31_weeks-Epithelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CD55 ITGA3 CDH1 FBN3	1.24e-04	193	59	4	a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH CFHR1 TIMP1 S1PR3	1.24e-04	193	59	4	e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TIMP1 JAG1 OAZ2 S1PR3	1.27e-04	194	59	4	7a7406c3b021aeafde423d20290c681c3e8ea0a6
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFHR1 CD55 CHD9 QSOX2	1.27e-04	194	59	4	d852aebf7a763b9a776c4570711f0c759f591910
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 JAG1 C11orf16 S1PR3	1.27e-04	194	59	4	3bff2e4eb16719ab7419b2f94c9c6e7302aa6629
ToppCell	LA-14._Fibroblast_III\|World / Chamber and Cluster_Paper	CFH ADAMTS4 CD55 SMAD3	1.27e-04	194	59	4	803fa83ceada17c38ca9f933b888f7e7b0b90761
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH TIMP1 ITGA3 CRB2	1.27e-04	194	59	4	43eb677a76634bb9a48a40e0d607c4936ae64bcc
ToppCell	18-Airway-Epithelial-Bud_tip_adjacent\|Airway / Age, Tissue, Lineage and Cell class	CFHR1 CD55 ITGA3 FBN3	1.27e-04	194	59	4	b45f1e80074a19245bc5dc4b3a583419a1904404
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 ADAMTS4 TRARG1 S1PR3	1.27e-04	194	59	4	b8a130ffae68ffe550bf335460a1ec1035cf8d8d
Computational	Genes in the cancer module 58.	CFH CFHR1 CD55 C4BPB	4.25e-07	21	33	4	MODULE_58
Computational	Complement.	CFH CFHR1 CD55 C4BPB	6.26e-07	23	33	4	MODULE_130
Drug	1ct8	CFH CFHR1 GJB6 JAG1 CFHR4 CFHR3	5.15e-06	173	58	6	CID000444888
Drug	(2S)-N-[4-(aminomethyl)-1,1-dioxothian-4-yl]-2-[1-(benzenesulfonamido)ethylideneamino]-3-(1-methylcyclopentyl)propanamide	CFH CFHR3	6.38e-06	2	58	2	CID011840931
Drug	Ticlopidine hydrochloride [53885-35-1]; Up 200; 13.4uM; HL60; HG-U133A	MON2 MDN1 CDK12 JAG1 CD55 MUTYH	1.11e-05	198	58	6	1975_UP
Disease	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial measurement	CFH CFHR1 CFHR4 CFHR3	1.08e-11	4	55	4	EFO_0803292
Disease	Atypical hemolytic-uremic syndrome	CFH CFHR1 CFHR4 CFHR3	1.35e-09	9	55	4	cv:C2931788
Disease	Hemolytic-uremic syndrome	CFH CFHR1 CFHR4 CFHR3	1.35e-09	9	55	4	cv:C0019061
Disease	Complement deficiency disease	CFH CFHR1 CD55 CFHR4 CFHR3	4.26e-09	33	55	5	C0272242
Disease	anaphase-promoting complex subunit 7 measurement	CFH CFHR1 CFHR3	6.13e-09	3	55	3	EFO_0801381
Disease	HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1	CFH CFHR1 CFHR3	6.13e-09	3	55	3	C2749604
Disease	HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1	CFH CFHR1 CFHR3	6.13e-09	3	55	3	235400
Disease	calnexin measurement	CFH CFHR1 CFHR4	6.13e-09	3	55	3	EFO_0801444
Disease	complement factor H-related protein 4A measurement	CFH CFHR1 CFHR4	6.13e-09	3	55	3	EFO_0600057
Disease	Hemolytic uremic syndrome, atypical, susceptibility to, 1	CFH CFHR1 CFHR3	6.13e-09	3	55	3	cv:C2749604
Disease	histone-lysine N-methyltransferase 2D measurement	CFH CFHR1 CFHR4	6.13e-09	3	55	3	EFO_0801683
Disease	kallikrein-5 measurement	CFH CFHR1 CFHR4	2.45e-08	4	55	3	EFO_0020515
Disease	complement C1s subcomponent measurement	CFH CFHR1 CFHR4	1.22e-07	6	55	3	EFO_0008091
Disease	Age related macular degeneration	CFH CFHR1 CFHR4 CFHR3	2.86e-07	30	55	4	C0242383
Disease	atypical hemolytic-uremic syndrome (is_implicated_in)	CFH CFHR1 CFHR3	3.41e-07	8	55	3	DOID:0080301 (is_implicated_in)
Disease	IGA Glomerulonephritis	CFHR1 TIMP1 CORO1C CFHR3	4.81e-07	34	55	4	C0017661
Disease	leukocyte immunoglobulin-like receptor subfamily A member 5 measurement	CFH CFHR1 CFHR4	5.11e-07	9	55	3	EFO_0801766
Disease	Atypical Hemolytic Uremic Syndrome	CFH CFHR1 CFHR3	7.29e-07	10	55	3	C2931788
Disease	hemopexin measurement	CFH CFHR1 CFHR4	1.00e-06	11	55	3	EFO_0008149
Disease	zinc finger protein 329 measurement	CFHR1 CFHR4	3.41e-06	2	55	2	EFO_0803276
Disease	phosphopantothenoylcysteine decarboxylase measurement	CFHR1 CFHR4	3.41e-06	2	55	2	EFO_0802867
Disease	level of otoraplin in blood serum	CFHR1 CFHR4	3.41e-06	2	55	2	OBA_2042720
Disease	c3d:C3 ratio	CFH CFHR4	3.41e-06	2	55	2	EFO_0008543
Disease	leucine-rich repeat-containing protein 19 measurement	CFHR1 CFHR4	3.41e-06	2	55	2	EFO_0801762
Disease	flap endonuclease 1 measurement	CFHR1 CFHR3	3.41e-06	2	55	2	EFO_0802551
Disease	protein FAM209B measurement	CFHR1 CFHR4	3.41e-06	2	55	2	EFO_0802943
Disease	Age-related macular degeneration	CFH CFHR1 CFHR3	4.90e-06	18	55	3	cv:C0242383
Disease	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase measurement	CFH CFHR3	1.02e-05	3	55	2	EFO_0801568
Disease	thrombospondin type-1 domain-containing protein 7A measurement	CFH C4BPB	1.02e-05	3	55	2	EFO_0803150
Disease	level of alpha-N-acetylglucosaminidase in blood serum	CFHR1 CFHR4	1.02e-05	3	55	2	OBA_2042500
Disease	soluble transferrin receptor measurement	CFHR1 CFHR4	1.02e-05	3	55	2	EFO_0004460
Disease	age related macular degeneration 1 (is_implicated_in)	CFHR1 CFHR3	2.04e-05	4	55	2	DOID:0110014 (is_implicated_in)
Disease	Meningococcal Infections	CFH CFHR3	2.04e-05	4	55	2	C0025303
Disease	Macular Degeneration, Age-Related, 1	CFHR1 CFHR3	2.04e-05	4	55	2	C1864205
Disease	MACULAR DEGENERATION, AGE-RELATED, 1	CFHR1 CFHR3	2.04e-05	4	55	2	603075
Disease	Age related macular degeneration 1	CFHR1 CFHR3	2.04e-05	4	55	2	cv:C1864205
Disease	complement factor H-related protein 2 measurement	CFH CFHR1 CFHR4	2.16e-05	29	55	3	EFO_0600055
Disease	Membranoproliferative Glomerulonephritis, Type II	CFH CFHR1	5.09e-05	6	55	2	C0268743
Disease	complement factor H measurement	CFH CFHR1 CFHR4	6.21e-05	41	55	3	EFO_0008097
Disease	complement factor H-related protein 5 measurement	CFH CFHR1 CFHR4	6.68e-05	42	55	3	EFO_0008098
Disease	DNA repair protein XRCC4 measurement	CFHR1 CFHR4	9.48e-05	8	55	2	EFO_0801532
Disease	complement factor H-related protein 4 measurement	CFH CFHR1 CFHR4	1.06e-04	49	55	3	EFO_0600091
Disease	pulmonary fibrosis (biomarker_via_orthology)	TIMP1 JAG1 CDH1	1.13e-04	50	55	3	DOID:3770 (biomarker_via_orthology)
Disease	C3 glomerulopathy	CFH CFHR1	1.22e-04	9	55	2	C4087273
Disease	synaptotagmin-11 measurement	CFH GON4L	1.22e-04	9	55	2	EFO_0802108
Disease	complement factor H-related protein 1 measurement	CFH CFHR1 CFHR4	1.58e-04	56	55	3	EFO_0600054
Disease	atrophic macular degeneration, age-related macular degeneration, wet macular degeneration	CFH CFHR1 CFHR4	1.94e-04	60	55	3	EFO_0001365, EFO_0004683, EFO_1001492
Disease	complement factor H-related protein 3 measurement	CFH CFHR1 CFHR4 CFHR3	2.82e-04	169	55	4	EFO_0600056
Disease	age-related macular degeneration, COVID-19	CFH CFHR1 CFHR4	2.94e-04	69	55	3	EFO_0001365, MONDO_0100096
Disease	SLAM family member 7 measurement	CFH ADAMTS4	4.56e-04	17	55	2	EFO_0008287
Disease	Benign neoplasm of stomach	CDH1 MUTYH	4.56e-04	17	55	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	CDH1 MUTYH	4.56e-04	17	55	2	C0496905
Disease	Carcinoma in situ of stomach	CDH1 MUTYH	4.56e-04	17	55	2	C0154060
Disease	mean platelet volume	ZAN TIMP1 CDK12 CORO1C EML6 RSF1 CHD9 C4BPB	5.72e-04	1020	55	8	EFO_0004584
Disease	age-related macular degeneration	CFH CFHR1 CFHR4	6.21e-04	89	55	3	EFO_0001365
Disease	coagulation factor measurement	CFH CFHR4	6.34e-04	20	55	2	EFO_0004634
Disease	COVID-19 (is_implicated_in)	CFH C4BPB	7.00e-04	21	55	2	DOID:0080600 (is_implicated_in)
Disease	Stomach Carcinoma	CDH1 MUTYH	7.00e-04	21	55	2	C0699791
Disease	Adenoid Cystic Carcinoma	JAG1 ARID1A CDH1	8.72e-04	100	55	3	C0010606
Disease	gastric adenocarcinoma (is_marker_for)	CDK12 ARID1A	1.25e-03	28	55	2	DOID:3717 (is_marker_for)
Disease	Ovarian Carcinoma	CDK12 CDH1	1.44e-03	30	55	2	C0029925
Disease	Liver Cirrhosis, Alcoholic	TIMP1 SMAD3	1.44e-03	30	55	2	C0023891
Disease	Breast Cancer, Familial	CDH1 MUTYH	1.44e-03	30	55	2	C0346153
Disease	chronic lymphocytic leukemia	ARSB SMAD3 SP140	1.44e-03	119	55	3	EFO_0000095

Protein segments in the cluster

Peptide	Gene	Start	Entry
VQWPCIPDLDSPFLC	PRAMEF33	251	A0A0G2JMD5
LCGSPCPAVWPDVIK	CDK12	951	Q9NYV4
ACPHRECIPWQGLLL	CEACAM21	6	Q3KPI0
VCGHTGPVLDIDWCP	CORO1C	76	Q9ULV4
QWSEPPKCLHPCVIS	CFH	1156	P08603
LPCHCKPEEVPAVVW	FAM187A	51	A6NFU0
RAWGLPCELCPAQPH	FBN3	216	Q75N90
PKLQWPTPDLCPACH	QSOX2	526	Q6ZRP7
CLPVLDGLLHWAVCP	ARID1A	2081	O14497
PQLQCCRHIVPGPLW	OAZ2	16	O95190
CRHIVPGPLWCSDAP	OAZ2	21	O95190
WLLQCCPSVGPAPGH	MDN1	4306	Q9NU22
PLPCVHGGSCVDLWT	CRB2	611	Q5IJ48
LWCPGQPCLPPATCE	CRB2	846	Q5IJ48
HVPCPPQCACQIRPW	LRRN2	26	O75325
LLCLPAVWGDCGLPP	CD55	26	P08174
CVWLECPIPDAPVVT	ITGA3	911	P26006
PGLQPPHCPGQCLIW	MYF6	66	P23409
CLPSTCPHTVWLLEP	KRTAP3-2	31	Q9BYR7
CLPSTCPHTVWLLEP	KRTAP3-3	31	Q9BYR6
PFHPAPPFDCLWLCL	MON2	1011	Q7Z3U7
LPWSPVVCVDHTPKC	OC90	366	Q02509
IWEQPPGCPLNTSHL	IQGAP3	691	Q86VI3
LPVIAPSCVDVAWPC	PAX4	311	O43316
PQLPPPCAALWCSGH	ADAMTS4	461	O75173
CHPNPDLPVWWECGP	CHD9	1951	Q3L8U1
GEWSEPPRCIHPCII	CFHR3	256	Q02985
PALPGCNVNILCHGW	IGSF1	141	Q8N6C5
KGRWVLITCCAPQPP	C17orf99	41	Q6UX52
YHLPWVLKCGIDPCP	GJB6	161	O95452
APEPDGCPVCVWRQH	GDF11	56	O95390
CCEEIQPHQWKPPIE	GON4L	896	Q3T8J9
CLEDHTWAPPFPICK	C4BPB	121	P20851
WSEPPRCIHPCIITE	CFHR4	506	Q92496
HQIIWPCQPSCVPLD	ARSB	111	P15848
PLHWQCPYIPLCPLV	DENND4B	446	O75064
TCVLGPTCEGIWPAH	EML6	1176	Q6ZMW3
AVTPLPWCPHLVAVC	HDAC6	1106	Q9UBN7
PWCPHLVAVCPIPAA	HDAC6	1111	Q9UBN7
WSEPPKCLHPCVISR	CFHR1	256	Q03591
MIIPDGEWFCPPCQH	RSF1	926	Q96T23
LPILGWNCLHNLPDC	S1PR3	171	Q99500
QVSSWLCQEPEPCHP	CDH1	16	P12830
RCPEHPSVPLANCWV	P2RX6	126	O15547
IPHPGCVHGICNEPW	JAG1	266	P78504
NCIDPWILPHGTCPI	RNF133	281	Q8WVZ7
PFLLNAVSWLCPCPG	TCAF2	76	A6NFQ2
ILHDVCGIPPFSPQW	OVCH1	556	Q7RTY7
CHLCLPPSEPWDQTL	MUTYH	336	Q9UIF7
PLHWAPCCSLLGPIT	C11orf16	236	Q9NQ32
WLIAPSRACTCVPPH	TIMP1	16	P01033
PPCNCGLVFHLQDPW	TNIP3	266	Q96KP6
WHPATVCKIPPGCNL	SMAD3	326	P84022
GPLWLQGEPLHFCCL	TMEM158	186	Q8WZ71
VQWPCIPDLDSPFLC	PRAMEF10	251	O60809
PLCREQHASWDPLPC	ZC3H12B	721	Q5HYM0
PLPHICNWVSANGPC	ZNF503	511	Q96F45
CHIPPVEAERTPWNC	SP140	716	Q13342
ACFCPVWPLNLIPLI	TRARG1	111	Q8IXB3
SLPILPQGCVWHPKC	WDCP	111	Q9H6R7
LQWHPEPPLADCGCT	ZAN	2641	Q9Y493
CEEWTIAVPGPPHSL	MYOM1	1031	P52179