Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K9 monomethyltransferase activity

EHMT2 ASH1L

3.86e-058242GO:0140948
GeneOntologyMolecularFunctionhistone H3K9me2 methyltransferase activity

EHMT2 ASH1L

6.19e-0510242GO:0140947
GeneOntologyMolecularFunctionhistone H3K9 methyltransferase activity

EHMT2 ASH1L

1.07e-0413242GO:0046974
GeneOntologyMolecularFunctionhistone modifying activity

EHMT2 TAF1 BRD1 ASH1L

1.50e-04229244GO:0140993
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

EHMT2 ASH1L

1.27e-0344242GO:0140938
GeneOntologyMolecularFunctionhistone acetyltransferase activity

TAF1 BRD1

1.70e-0351242GO:0004402
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

TAF1 BRD1

1.98e-0355242GO:0061733
GeneOntologyMolecularFunctionpeptide N-acetyltransferase activity

TAF1 BRD1

2.35e-0360242GO:0034212
GeneOntologyMolecularFunctiongeneral transcription initiation factor activity

TAF1 GTF3C1

3.00e-0368242GO:0140223
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

EHMT2 ASH1L

3.00e-0368242GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

EHMT2 ASH1L

3.09e-0369242GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

EHMT2 ASH1L

3.27e-0371242GO:0042054
GeneOntologyMolecularFunctionp53 binding

EHMT2 TAF1

3.83e-0377242GO:0002039
GeneOntologyMolecularFunctionN-acetyltransferase activity

TAF1 BRD1

3.93e-0378242GO:0008080
GeneOntologyMolecularFunctionpromoter-specific chromatin binding

EHMT2 TAF1

4.44e-0383242GO:1990841
GeneOntologyMolecularFunctionN-acyltransferase activity

TAF1 BRD1

6.63e-03102242GO:0016410
GeneOntologyMolecularFunctionprotein methyltransferase activity

EHMT2 ASH1L

6.75e-03103242GO:0008276
GeneOntologyMolecularFunctionacetyltransferase activity

TAF1 BRD1

6.88e-03104242GO:0016407
GeneOntologyMolecularFunctionN-methyltransferase activity

EHMT2 ASH1L

7.01e-03105242GO:0008170
HumanPhenoDepressed nasal bridge

PIGQ ADA2 DPH2 TAF1 NAGA ASH1L

6.64e-0561286HP:0005280
HumanPhenoFlattened nasal bridge

PIGQ ADA2 DPH2 TAF1 NAGA ASH1L

6.64e-0561286HP:0000425
HumanPhenoCerebral visual impairment

PIGQ KIF1A ADA2 NAGA

9.24e-0517984HP:0100704
DomainBROMODOMAIN_1

TAF1 BRD1 ASH1L

1.41e-0537243PS00633
DomainBromodomain

TAF1 BRD1 ASH1L

1.53e-0538243PF00439
DomainBROMODOMAIN_2

TAF1 BRD1 ASH1L

1.92e-0541243PS50014
DomainBROMO

TAF1 BRD1 ASH1L

2.07e-0542243SM00297
DomainBromodomain

TAF1 BRD1 ASH1L

2.07e-0542243IPR001487
Domain-

TAF1 BRD1 ASH1L

2.07e-05422431.20.920.10
DomainPost-SET_dom

EHMT2 ASH1L

1.88e-0416242IPR003616
DomainPostSET

EHMT2 ASH1L

1.88e-0416242SM00508
DomainPOST_SET

EHMT2 ASH1L

1.88e-0416242PS50868
DomainBromodomain_CS

TAF1 BRD1

5.05e-0426242IPR018359
DomainSET

EHMT2 ASH1L

1.26e-0341242PF00856
DomainSET

EHMT2 ASH1L

1.58e-0346242SM00317
DomainSET_dom

EHMT2 ASH1L

1.87e-0350242IPR001214
DomainSET

EHMT2 ASH1L

1.87e-0350242PS50280
DomainZinc_finger_PHD-type_CS

BRD1 ASH1L

3.13e-0365242IPR019786
DomainPHD

BRD1 ASH1L

4.15e-0375242PF00628
DomainZnf_PHD-finger

BRD1 ASH1L

4.59e-0379242IPR019787
DomainPHD

BRD1 ASH1L

5.79e-0389242SM00249
DomainZnf_PHD

BRD1 ASH1L

6.04e-0391242IPR001965
DomainZF_PHD_2

BRD1 ASH1L

6.57e-0395242PS50016
DomainZF_PHD_1

BRD1 ASH1L

6.70e-0396242PS01359
Pubmed

Histone H2A ubiquitination inhibits the enzymatic activity of H3 lysine 36 methyltransferases.

EHMT2 ASH1L

6.83e-06624224019522
Pubmed

New nomenclature for chromatin-modifying enzymes.

EHMT2 TAF1 ASH1L

8.24e-065724318022353
Pubmed

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

TAF1 BRD1 ASH1L

1.89e-057524325593309
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

EHMT2 DAP3 TAF1 BRD1 GTF3C1

5.18e-0560824536089195
Pubmed

Isolation and characterization of proteins associated with histone H3 tails in vivo.

EHMT2 ASH1L

1.96e-043024217403666
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

EHMT2 DENND4A BRD1 ASH1L GTF3C1

2.88e-0487724520211142
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

EHMT2 TAF1 ASH1L GTF3C1

4.54e-0453324430554943
Pubmed

The DNA sequence and biological annotation of human chromosome 1.

DAP3 FAAH HSPB7 COL16A1 ASH1L

6.03e-04103124516710414
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

EHMT2 TAF1 CHERP GTF3C1

6.36e-0458324429844126
Pubmed

Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).

EHMT2 CHERP

6.63e-045524227114453
Cytoband1p35-p34

FAAH COL16A1

5.49e-0672421p35-p34
Cytoband1q22

DAP3 ASH1L

4.11e-04572421q22
CytobandEnsembl 112 genes in cytogenetic band chr1q22

DAP3 ASH1L

6.37e-0471242chr1q22
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

EHMT2 ASH1L

4.05e-0434162487
GeneFamilyPHD finger proteins

BRD1 ASH1L

2.81e-039016288
CoexpressionGSE5503_LIVER_DC_VS_PLN_DC_ACTIVATED_ALLOGENIC_TCELL_UP

EHMT2 ARHGEF39 PHKG2 COL16A1 CHERP

9.07e-07199245M6992
CoexpressionMOTAMED_RESPONSE_TO_ANDROGEN_DN

ACHE ASH1L

1.20e-056242M1149
CoexpressionGSE5589_LPS_VS_LPS_AND_IL10_STIM_IL6_KO_MACROPHAGE_45MIN_UP

GHDC PIGQ EHMT2 GTF3C1

3.10e-05200244M6618
CoexpressionCONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP

DAP3 ACHE PHKG2 COL16A1

6.21e-05239244M4716
ToppCellPND14-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF1A ARHGEF39 NAGA

8.61e-05161243afc719ffa53ab34c5628da47936da1f731dceab1
ToppCellPND14-Immune-Immune_Myeloid-DC-cDC1|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF1A ARHGEF39 NAGA

9.10e-0516424390404b3b6b6a9b88a75cba09baa94c718e577c44
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

KIF1A MARCHF4 PLPPR1

9.60e-05167243c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCelldroplet-Liver-nan-3m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLPPR1 MTCL1 COL16A1

1.05e-04172243f814b6134ad608015765399d54cc1e5e1873ed34
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGEF39 MTCL1 NAGA

1.07e-04173243506efcaa5afd6ed5e565c4c4def6a4505fea97c5
ToppCell368C-Myeloid-Dendritic-cDC_proliferating_1|368C / Donor, Lineage, Cell class and subclass (all cells)

ARHGEF39 ACHE FAAH

1.18e-04179243ec69e1dd897414033ba5b007aa82655a79adca6c
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF1A PLPPR1 ACHE

1.22e-041812437af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCellfacs-Lung-Endomucin-24m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACHE MTCL1 COL16A1

1.24e-0418224374dbb706bcaa0f8c922bf3b0424bce5bb27167fa
ToppCellfacs-Lung-Endomucin-24m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACHE MTCL1 COL16A1

1.24e-04182243be9c312a44868d4ee266a64d066feb8c5bce5687
ToppCellFetal_29-31_weeks-Immune-enucleated_erythrocyte-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PIGQ TMEM131L DENND4A

1.30e-04185243e8f7da9641b6cf1db1093b4f301ce828fd3a529c
ToppCellfacs-Lung-24m-Mesenchymal-myofibroblast-pericyte_cell-pericyte|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACHE HSPB7 COL16A1

1.30e-04185243a6cd90f8f30c7bdf66958cf403e73c193aa32f5e
ToppCellfacs-Lung-24m-Mesenchymal-myofibroblast-pericyte_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACHE HSPB7 COL16A1

1.30e-041852435053f932e2adfcf4d6faaecff2999ac53d8d7aa5
ToppCell368C-Myeloid-Dendritic-cDC_proliferating_1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ARHGEF39 ACHE FAAH

1.32e-04186243799903b68bc6f6205d004b44c603424b0d5f7c32
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MTCL1 HSPB7 COL16A1

1.36e-04188243c29aaae3c5bb7cd6b9b3defd4d27afde3af19ba0
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MTCL1 HSPB7 COL16A1

1.36e-041882434d1e5f85342ae550086609d7680e32730b78b5d2
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

TMEM131L DENND4A ASH1L

1.36e-04188243ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-muscle|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

KIF1A HSPB7 COL16A1

1.36e-04188243b01cb642f8b2d83235706fec7477c15005094161
ToppCellMesenchymal-airway_smooth_muscle_cell|World / Lineage, Cell type, age group and donor

MTCL1 HSPB7 COL16A1

1.41e-04190243645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

TMEM131L DENND4A ASH1L

1.45e-0419224347646d7e4990be85072987f92bf18d52f8da752e
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PIGQ ACHE DENND4A

1.47e-04193243305e15ee467826ee08b2617c69f250ad39c11b19
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-erythrocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PIGQ ACHE DENND4A

1.47e-04193243dd376664906caccc9c2065f8e7a364509e18a5cc
ToppCellTCGA-Adrenal-Primary_Tumor-Pheochromocytoma|TCGA-Adrenal / Sample_Type by Project: Shred V9

KIF1A MARCHF4 MTCL1

1.49e-04194243b6488bc3a8905e926ad298332963e1bbaf010046
ToppCellTCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma|TCGA-Adrenal / Sample_Type by Project: Shred V9

KIF1A MARCHF4 MTCL1

1.49e-041942431e1f4139ad584f493d75a9b7f1568eca4653c5a2
ToppCellBronchus_Control_(B.)-Endothelial-TX|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

KIF1A PLPPR1 MTCL1

1.59e-04198243feac39036b5c0ab97b524cc366286942d136d42f
ToppCellBronchus_Control_(B.)-Endothelial-TX-Bronchial_vessel|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

KIF1A PLPPR1 MTCL1

1.59e-04198243dcf334d13e5b0018fee24febccfef91c9e17843b
Drugbutyl phosphorotrithioate

ACHE FAAH

6.38e-064242ctd:C006863
Drugethyl octylphosphonofluoridate

ACHE FAAH

2.23e-057242ctd:C100419
Drugalpha-estradiol; Down 200; 0.01uM; MCF7; HT_HG-U133A_EA

DENND4A FAAH TAF1 NAGA

4.75e-05194244990_DN
Drughaloperidol; Down 200; 10uM; PC3; HT_HG-U133A

DPH2 TAF1 BRD1 ASH1L

5.14e-051982441244_DN
DrugAlverine citrate salt [5560-59-8]; Up 200; 8.4uM; PC3; HT_HG-U133A

PIGQ KIF1A PLPPR1 ASH1L

5.14e-051982446345_UP
Drugprofenofos

ACHE FAAH

2.00e-0420242CID000038779
Drugmethamidophos

ACHE FAAH

2.00e-0420242ctd:C014655
DrugFenitrothion

ACHE FAAH

4.25e-0429242ctd:D005278
Drugtribufos

ACHE FAAH

4.86e-0431242CID000005125
Drugprofenofos

ACHE FAAH

6.56e-0436242ctd:C024273
DrugSistan

FAAH TAF1

6.56e-0436242CID003001858
DrugZinc Sulfate

KIF1A MARCHF4 PLPPR1 MTCL1 BRD1

9.04e-04739245ctd:D019287
DrugAminosweet

ACHE NAGA

9.37e-0443242CID000002242
DrugCeforanide [60925-61-3]; Down 200; 7.6uM; MCF7; HT_HG-U133A

KIF1A FAAH NAGA

1.03e-031912435351_DN
DiseaseSeizures

PLPPR1 ACHE FAAH NAGA

2.74e-05218244C0036572
DiseaseVisual seizure

PLPPR1 ACHE FAAH

7.48e-05101243C0270824
DiseaseEpileptic drop attack

PLPPR1 ACHE FAAH

7.48e-05101243C0270846
DiseaseGeneralized seizures

PLPPR1 ACHE FAAH

7.48e-05101243C0234533
DiseaseClonic Seizures

PLPPR1 ACHE FAAH

7.48e-05101243C0234535
DiseaseVertiginous seizure

PLPPR1 ACHE FAAH

7.48e-05101243C0422855
DiseaseGustatory seizure

PLPPR1 ACHE FAAH

7.48e-05101243C0422854
DiseaseSeizures, Somatosensory

PLPPR1 ACHE FAAH

7.48e-05101243C0422850
DiseaseOlfactory seizure

PLPPR1 ACHE FAAH

7.48e-05101243C0422853
DiseaseSeizures, Auditory

PLPPR1 ACHE FAAH

7.48e-05101243C0422852
DiseaseGeneralized Absence Seizures

PLPPR1 ACHE FAAH

7.48e-05101243C4505436
DiseaseConvulsive Seizures

PLPPR1 ACHE FAAH

7.48e-05101243C0751494
DiseaseSeizures, Sensory

PLPPR1 ACHE FAAH

7.48e-05101243C0751496
DiseaseAtonic Absence Seizures

PLPPR1 ACHE FAAH

7.48e-05101243C0751123
DiseaseComplex partial seizures

PLPPR1 ACHE FAAH

7.48e-05101243C0149958
DiseaseSingle Seizure

PLPPR1 ACHE FAAH

7.48e-05101243C0751110
DiseaseEpileptic Seizures

PLPPR1 ACHE FAAH

7.48e-05101243C4317109
DiseaseJacksonian Seizure

PLPPR1 ACHE FAAH

7.48e-05101243C0022333
DiseaseNon-epileptic convulsion

PLPPR1 ACHE FAAH

7.48e-05101243C0751056
DiseaseNonepileptic Seizures

PLPPR1 ACHE FAAH

7.48e-05101243C3495874
DiseaseTonic Seizures

PLPPR1 ACHE FAAH

7.70e-05102243C0270844
DiseaseAbsence Seizures

PLPPR1 ACHE FAAH

7.70e-05102243C4316903
DiseaseConvulsions

PLPPR1 ACHE FAAH

7.70e-05102243C4048158
DiseaseSeizures, Focal

PLPPR1 ACHE FAAH

8.16e-05104243C0751495
DiseaseMyoclonic Seizures

PLPPR1 ACHE FAAH

8.16e-05104243C4317123
DiseaseTonic - clonic seizures

PLPPR1 ACHE FAAH

8.16e-05104243C0494475

Protein segments in the cluster

PeptideGeneStartEntry
IPFAEPPMGPRRFLP

ACHE

66

P22303
MHLPERPAAAPRRPF

BRD1

681

O95696
RPVDREVPMIPRPHY

ASH1L

2631

Q9NR48
PRRPMRPVGHVFLGL

COL16A1

196

Q07092
PEPMPLERFGRRFPL

DPH2

191

Q9BQC3
PVPEKRPPEIQHFRM

EHMT2

196

Q96KQ7
VVPPHGEPRPRMFFL

ARHGEF39

236

Q8N4T4
HFMHKVPFPSPQRPR

DENND4A

351

Q7Z401
PFPHQGSLRMPRPVA

MTCL1

1296

Q9Y4B5
PFPPAMPRVLRHRHL

GHDC

506

Q8N2G8
AALFQHRPPGPFPIM

PHKG2

371

P15735
MRPHSEPLAFPARPG

HSPB7

56

Q9UBY9
EPPFRMQRPPHFRGP

CHERP

511

Q8IWX8
RFPPRFMQDDFPPRH

CHERP

546

Q8IWX8
RGIMQFRFAHPTPRP

ADA2

141

Q9NZK5
VFLLRRPPQAPLPMH

MARCHF4

51

Q9P2E8
DMFRLDPTVPPLPFR

FAAH

301

O00519
RHFPRVMPLSKPVPA

KIF1A

1101

Q12756
ETVFPHGLPPRFVMQ

DAP3

76

P51398
FHVPPVPCRVIPAMG

TMEM131L

136

A2VDJ0
VELRQPFFPTHMGPI

TAF1

596

P21675
PSLPEPHGVYLRMFP

PIGQ

741

Q9BRB3
PEDPRGVPLMAFPRI

PLPPR1

291

Q8TBJ4
MRYIPPIPVHRDFGF

GTF3C1

886

Q12789
LMPDPKRFPHGIPFL

NAGA

91

P17050