Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	bile acid binding	NAPEPLD AKR1C1 AKR1C2	4.89e-05	10	151	3	GO:0032052
GeneOntologyMolecularFunction	monocarboxylic acid binding	NAPEPLD PPARD AKR1C1 AKR1C2 GSTM2 NME2	1.63e-04	107	151	6	GO:0033293
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	STAB2 STAB1 LRP1	2.21e-04	16	151	3	GO:0005041
GeneOntologyMolecularFunction	androsterone dehydrogenase (B-specific) activity	AKR1C1 AKR1C2	3.37e-04	4	151	2	GO:0047042
GeneOntologyMolecularFunction	ketoreductase activity	AKR1C1 AKR1C2	3.37e-04	4	151	2	GO:0045703
GeneOntologyMolecularFunction	indanol dehydrogenase activity	AKR1C1 AKR1C2	3.37e-04	4	151	2	GO:0047718
GeneOntologyMolecularFunction	chlordecone reductase activity	AKR1C1 AKR1C2	3.37e-04	4	151	2	GO:0047743
GeneOntologyMolecularFunction	carboxylic acid binding	NAPEPLD PPARD AKR1C1 AKR1C2 GSTM2 DHFR2 SARDH NME2	4.79e-04	239	151	8	GO:0031406
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	STAB2 STAB1 LRP1	5.10e-04	21	151	3	GO:0030228
GeneOntologyMolecularFunction	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	AKR1C1 AKR1C2	5.60e-04	5	151	2	GO:0047115
GeneOntologyMolecularFunction	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	5.60e-04	5	151	2	GO:0047020
GeneOntologyMolecularFunction	17-beta-ketosteroid reductase (NADPH) activity	AKR1C1 AKR1C2	5.60e-04	5	151	2	GO:0072555
GeneOntologyMolecularFunction	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	AKR1C1 AKR1C2	5.60e-04	5	151	2	GO:0047006
GeneOntologyMolecularFunction	lithocholic acid binding	AKR1C1 AKR1C2	5.60e-04	5	151	2	GO:1902121
GeneOntologyMolecularFunction	ketosteroid monooxygenase activity	AKR1C1 AKR1C2	5.60e-04	5	151	2	GO:0047086
GeneOntologyMolecularFunction	Delta4-3-oxosteroid 5beta-reductase activity	AKR1C1 AKR1C2	5.60e-04	5	151	2	GO:0047787
GeneOntologyMolecularFunction	organic acid binding	NAPEPLD PPARD AKR1C1 AKR1C2 GSTM2 DHFR2 SARDH NME2	7.14e-04	254	151	8	GO:0043177
GeneOntologyMolecularFunction	geranylgeranyl reductase activity	AKR1C1 AKR1C2	8.35e-04	6	151	2	GO:0045550
GeneOntologyMolecularFunction	NADPH binding	AKR1C1 AKR1C2 DHFR2	9.70e-04	26	151	3	GO:0070402
GeneOntologyMolecularFunction	scavenger receptor activity	STAB2 STAB1 LRP1	1.09e-03	27	151	3	GO:0005044
GeneOntologyMolecularFunction	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	1.16e-03	7	151	2	GO:0072582
GeneOntologyMolecularFunction	peptidase activity	ZC3H12A ADAMTS2 FOLH1 TMPRSS5 USP46 ADAM32 LACTB BAP1 MMP24 CPQ HPR UCHL3 VASH2	1.42e-03	654	151	13	GO:0008233
GeneOntologyMolecularFunction	5alpha-androstane-3beta,17beta-diol dehydrogenase activity	AKR1C1 AKR1C2	1.54e-03	8	151	2	GO:0047024
GeneOntologyMolecularFunction	androsterone dehydrogenase activity	AKR1C1 AKR1C2	1.54e-03	8	151	2	GO:0047023
GeneOntologyMolecularFunction	enone reductase activity	AKR1C1 AKR1C2	1.54e-03	8	151	2	GO:0035671
GeneOntologyMolecularFunction	androstan-3-alpha,17-beta-diol dehydrogenase activity	AKR1C1 AKR1C2	1.98e-03	9	151	2	GO:0047044
GeneOntologyMolecularFunction	primary methylamine oxidase activity	DAO VCAM1	1.98e-03	9	151	2	GO:0008131
GeneOntologyMolecularFunction	NADP+ binding	AKR1C1 AKR1C2	1.98e-03	9	151	2	GO:0070401
GeneOntologyMolecularFunction	oxidoreductase activity	STAB2 CYP8B1 PRXL2B DAO PIR AKR1C1 AKR1C2 STAB1 GSTM2 COX5A AGMO DHFR2 SARDH VCAM1	2.05e-03	766	151	14	GO:0016491
Domain	DUF1712	CCZ1B CCZ1	6.49e-05	2	151	2	PF08217
Domain	DUF1712_fun	CCZ1B CCZ1	6.49e-05	2	151	2	IPR013176
Domain	GFP-like	STAB2 STAB1 HMCN1	8.15e-05	11	151	3	IPR023413
Domain	-	STAB2 STAB1 HMCN1	8.15e-05	11	151	3	2.40.155.10
Domain	FAS1	STAB2 STAB1	3.85e-04	4	151	2	SM00554
Domain	FAS1_domain	STAB2 STAB1	3.85e-04	4	151	2	IPR000782
Domain	Peptidase_C12	BAP1 UCHL3	3.85e-04	4	151	2	PF01088
Domain	Peptidase_C12_UCH	BAP1 UCHL3	3.85e-04	4	151	2	IPR001578
Domain	-	STAB2 STAB1	3.85e-04	4	151	2	2.30.180.10
Domain	FAS1	STAB2 STAB1	3.85e-04	4	151	2	PS50213
Domain	Fasciclin	STAB2 STAB1	3.85e-04	4	151	2	PF02469
Domain	UCH_1	BAP1 UCHL3	3.85e-04	4	151	2	PS00140
Domain	-	BAP1 UCHL3	3.85e-04	4	151	2	3.40.532.10
Domain	TF_GTP-bd_dom	HBS1L BMS1 EIF5B	4.56e-04	19	151	3	IPR000795
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL	CYP8B1 AKR1C1 AKR1C2	1.28e-04	13	111	3	M17842
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL	CYP8B1 AKR1C1 AKR1C2	1.28e-04	13	111	3	MM14747
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL	CYP8B1 AKR1C1 AKR1C2	1.62e-04	14	111	3	M27074
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL	CYP8B1 AKR1C1 AKR1C2	1.62e-04	14	111	3	MM14748
Pathway	REACTOME_SYNTHESIS_OF_PROSTAGLANDINS_PG_AND_THROMBOXANES_TX	CYP8B1 AKR1C1 AKR1C2	2.02e-04	15	111	3	MM14870
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	COL4A2 CASP8AP2 POGLUT3 GAK ATP7A ANK3 BMS1 GPAT3 PSMC4 MPDZ ZFC3H1 LACTB ACSL3 CACTIN NEO1 NDC1 COX5A ASNS PES1 PPA2 WRAP73 EIF5B PDCD11 MACF1 TTC17 HSPA6 PUS7 EPHA7	1.00e-10	1487	155	28	33957083
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	CCZ1B POGLUT3 GAK GPAT3 PSMC4 DYNC2I1 MPDZ FARP2 PIKFYVE YEATS2 NEO1 ALMS1 PES1 TTC17 CTPS1	1.11e-06	733	155	15	34672954
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	HBS1L GAK ANK3 NSD1 MPDZ SIN3A YEATS2 MSH6 BRD8 ALMS1 PDCD11 CTPS1 HSPA6	1.22e-06	549	155	13	38280479
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	HBS1L ZFC3H1 FANCM FARP2 PIKFYVE FAT2 ALMS1 EIF5B UBR3 MACF1 ARHGAP25 PUS7	2.40e-06	493	155	12	15368895
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	HBS1L POGLUT3 GAK SETX GTPBP6 BMS1 PSMC4 PIR ACSL3 NDC1 PES1 PPA2 EIF5B PDCD11 MACF1 TTC17 CTPS1 HSPA6 XPOT	5.61e-06	1297	155	19	33545068
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	CCZ1B HBS1L AHI1 SETX ANK3 NSD1 ZNF101 PRAMEF17 AKR1C1 AKR1C2 BRD8 HAUS1 COQ8A CCZ1 MACF1 XPOT BRWD1	7.51e-06	1084	155	17	11544199
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	CASP8AP2 GAK SETX TBKBP1 TBC1D2B PSMC4 PIKFYVE YEATS2 ALMS1 MACF1 NME2 HSF2	1.41e-05	588	155	12	38580884
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	C2orf88 RTTN NME2P1 CFAP43 MSH6 PRDM11 BRD8 DNAH12 PES1 EIF5B MACF1	1.52e-05	496	155	11	31343991
Pubmed	Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.	AKR1C1 AKR1C2	1.97e-05	2	155	2	8573067
Pubmed	FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products.	STAB2 STAB1	1.97e-05	2	155	2	12473645
Pubmed	OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB.	LACTB OXCT1	1.97e-05	2	155	2	38176415
Pubmed	Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.	AKR1C1 AKR1C2	1.97e-05	2	155	2	15492289
Pubmed	FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells.	SETX FANCD2	1.97e-05	2	155	2	36543851
Pubmed	Characterization of the human nm23-H2 promoter region and localization of the microsatellite D17S396.	NME2P1 NME2	1.97e-05	2	155	2	7488060
Pubmed	Mechanism for phosphatidylserine-dependent erythrophagocytosis in mouse liver.	STAB2 STAB1	1.97e-05	2	155	2	21427291
Pubmed	Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding.	STAB2 STAB1	1.97e-05	2	155	2	15572036
Pubmed	Phenotypical and biochemical characterization of murine psoriasiform and fibrotic skin disease models in Stabilin-deficient mice.	STAB2 STAB1	1.97e-05	2	155	2	38946049
Pubmed	Modeling single nucleotide polymorphisms in the human AKR1C1 and AKR1C2 genes: implications for functional and genotyping analyses.	AKR1C1 AKR1C2	1.97e-05	2	155	2	21217827
Pubmed	FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities.	STAB2 STAB1	1.97e-05	2	155	2	12077138
Pubmed	cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family.	AKR1C1 AKR1C2	1.97e-05	2	155	2	8486699
Pubmed	Scavenging Endothelium of Pancreatic Islets: Differential Expression of Stabilin-1 and Stabilin-2 in Mice and Humans.	STAB2 STAB1	1.97e-05	2	155	2	27977633
Pubmed	Long chain acyl-CoA synthetase-3 is a molecular target for peroxisome proliferator-activated receptor delta in HepG2 hepatoma cells.	PPARD ACSL3	1.97e-05	2	155	2	20308079
Pubmed	Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.	AKR1C1 AKR1C2	1.97e-05	2	155	2	11514561
Pubmed	Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M.	FANCM FANCD2	1.97e-05	2	155	2	19423727
Pubmed	Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study.	STAB2 STAB1	1.97e-05	2	155	2	33008099
Pubmed	Exploring the transcriptomic network of multi-ligand scavenger receptor Stabilin-1- and Stabilin-2-deficient liver sinusoidal endothelial cells.	STAB2 STAB1	1.97e-05	2	155	2	33130055
Pubmed	cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.	AKR1C1 AKR1C2	1.97e-05	2	155	2	8011662
Pubmed	Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors.	STAB2 STAB1	1.97e-05	2	155	2	21293057
Pubmed	The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development.	DAO LRP1	1.97e-05	2	155	2	17942912
Pubmed	Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors.	AKR1C1 AKR1C2	1.97e-05	2	155	2	18654764
Pubmed	Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues.	STAB2 STAB1	1.97e-05	2	155	2	11829752
Pubmed	The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell death.	AKR1C1 AKR1C2	1.97e-05	2	155	2	26934124
Pubmed	Association of Differentially Altered Liver Fibrosis with Deposition of TGFBi in Stabilin-Deficient Mice.	STAB2 STAB1	1.97e-05	2	155	2	37446152
Pubmed	The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.	CYP8B1 AKR1C1 AKR1C2	2.40e-05	13	155	3	11682476
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CASP8AP2 SETX BMS1 TBC1D2B BAP1 STAB1 AGO4 COQ8A PDCD11 ARHGAP20 PADI2	2.74e-05	529	155	11	14621295
Pubmed	Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.	CHIA TMPRSS5 PRKG1	3.80e-05	15	155	3	25338677
Pubmed	DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.	ZC3H12A IL18RAP UCHL3 PPA2 ARHGAP29 PRKG1 HSF2 VCAM1 BRWD1	4.01e-05	364	155	9	31391242
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	GTPBP6 TMEM135 BMS1 GPAT3 PSMC4 DYNC2I1 LACTB FANCD2 PIKFYVE ACSL3 NDC1 OXCT1 ALMS1 COX5A PPA2 WRAP73 PDCD11 TTC17 NME2	4.03e-05	1496	155	19	32877691
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	HBS1L UXS1 SETX GTPBP6 BMS1 NSD1 MPDZ ZFC3H1 FARP2 MSH6 BRD8 COX5A PES1 EIF5B PDCD11 MACF1 NME2 HSPA6 DUSP11	4.07e-05	1497	155	19	31527615
Pubmed	SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.	PSMC4 FANCD2 COX5A COQ8A ASNS PES1 PDCD11 CTPS1 NME2 HSPA6	4.67e-05	463	155	10	34901782
Pubmed	Discovery and refinement of loci associated with lipid levels.	HBS1L C5orf67 CETP LACTB STAB1 HPR LRP1	4.77e-05	211	155	7	24097068
Pubmed	Biological, clinical and population relevance of 95 loci for blood lipids.	C5orf67 CETP LACTB HPR LRP1 MACF1	5.16e-05	146	155	6	20686565
Pubmed	Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.	AKR1C1 AKR1C2	5.90e-05	3	155	2	19320734
Pubmed	Highly oxidized albumin is cleared by liver sinusoidal endothelial cells via the receptors stabilin-1 and -2.	STAB2 STAB1	5.90e-05	3	155	2	37926735
Pubmed	Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.	AKR1C1 AKR1C2	5.90e-05	3	155	2	31780644
Pubmed	Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.	AKR1C1 AKR1C2	5.90e-05	3	155	2	13678667
Pubmed	PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.	CCZ1B CCZ1	5.90e-05	3	155	2	32160108
Pubmed	Interleukin 1β regulates progesterone metabolism in human cervical fibroblasts.	AKR1C1 AKR1C2	5.90e-05	3	155	2	22064385
Pubmed	Involvement of Galectin-3 with vascular cell adhesion molecule-1 in growth regulation of mouse BALB/3T3 cells.	LRP1 VCAM1	5.90e-05	3	155	2	19858221
Pubmed	Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1.	NME2P1 NME2	5.90e-05	3	155	2	8270257
Pubmed	Evidence of a structural and functional ammonium transporter RhBG·anion exchanger 1·ankyrin-G complex in kidney epithelial cells.	ANK3 SLC4A1	5.90e-05	3	155	2	25616663
Pubmed	Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2.	FANCM FANCD2	5.90e-05	3	155	2	31067464
Pubmed	Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.	AKR1C1 AKR1C2	5.90e-05	3	155	2	21232532
Pubmed	Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells.	SLC25A20 PPARD	5.90e-05	3	155	2	19577614
Pubmed	Stabilin receptors clear LPS and control systemic inflammation.	STAB2 STAB1	5.90e-05	3	155	2	34816100
Pubmed	The structure of the human red blood cell anion exchanger (EPB3, AE1, band 3) gene.	ATP7A SLC4A1	5.90e-05	3	155	2	8081002
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	CASP8AP2 SETX NSD1 SIN3A ZFC3H1 FANCM BAP1 ACSL3 YEATS2 CACTIN PRDM11 BRD8 NDC1 COX5A POLR3E PDCD11 HSPA6	7.00e-05	1294	155	17	30804502
Pubmed	Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.	ANK3 BAP1 STAB1 EIF5B TMEM151A	9.69e-05	102	155	5	21926972
Pubmed	Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).	AKR1C1 AKR1C2	1.18e-04	4	155	2	10500239
Pubmed	AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.	AKR1C1 AKR1C2	1.18e-04	4	155	2	19487289
Pubmed	Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	1.18e-04	4	155	2	14967952
Pubmed	Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.	AKR1C1 AKR1C2	1.18e-04	4	155	2	10393440
Pubmed	Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.	AKR1C1 AKR1C2	1.18e-04	4	155	2	15193432
Pubmed	Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.	AKR1C1 AKR1C2	1.18e-04	4	155	2	31479646
Pubmed	Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.	AKR1C1 AKR1C2	1.18e-04	4	155	2	16191478
Pubmed	Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.	AKR1C1 AKR1C2	1.18e-04	4	155	2	15577209
Pubmed	Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.	AKR1C1 AKR1C2	1.18e-04	4	155	2	10702227
Pubmed	Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.	AKR1C1 AKR1C2	1.18e-04	4	155	2	17034817
Pubmed	RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.	AKR1C1 AKR1C2	1.18e-04	4	155	2	29764944
Pubmed	Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.	AKR1C1 AKR1C2	1.18e-04	4	155	2	17888864
Pubmed	Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.	AKR1C1 AKR1C2	1.18e-04	4	155	2	17442338
Pubmed	Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.	AKR1C1 AKR1C2	1.18e-04	4	155	2	28329705
Pubmed	Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.	AKR1C1 AKR1C2	1.18e-04	4	155	2	19237748
Pubmed	Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.	AKR1C1 AKR1C2	1.18e-04	4	155	2	28259989
Pubmed	Targeting of Scavenger Receptors Stabilin-1 and Stabilin-2 Ameliorates Atherosclerosis by a Plasma Proteome Switch Mediating Monocyte/Macrophage Suppression.	STAB2 STAB1	1.18e-04	4	155	2	36325910
Pubmed	Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration.	BAP1 UCHL3	1.18e-04	4	155	2	32486284
Pubmed	Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.	AKR1C1 AKR1C2	1.18e-04	4	155	2	16511129
Pubmed	Deficiency for scavenger receptors Stabilin-1 and Stabilin-2 leads to age-dependent renal and hepatic depositions of fasciclin domain proteins TGFBI and Periostin in mice.	STAB2 STAB1	1.18e-04	4	155	2	37357460
Pubmed	Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.	AKR1C1 AKR1C2	1.18e-04	4	155	2	7789999
Pubmed	Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.	AKR1C1 AKR1C2	1.18e-04	4	155	2	20124700
Pubmed	Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.	AKR1C1 AKR1C2	1.18e-04	4	155	2	16508162
Pubmed	Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	1.18e-04	4	155	2	15222881
Pubmed	Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.	AKR1C1 AKR1C2	1.18e-04	4	155	2	17629694
Pubmed	Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.	AKR1C1 AKR1C2	1.18e-04	4	155	2	10526179
Pubmed	Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.	AKR1C1 AKR1C2	1.18e-04	4	155	2	16018803
Pubmed	Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	1.18e-04	4	155	2	17272929
Pubmed	Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.	AKR1C1 AKR1C2	1.18e-04	4	155	2	18667791
Pubmed	Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells.	CCZ1B CCZ1	1.18e-04	4	155	2	20305638
Pubmed	Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.	AKR1C1 AKR1C2	1.18e-04	4	155	2	21521174
Pubmed	Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.	AKR1C1 AKR1C2	1.18e-04	4	155	2	8274401
Pubmed	Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase.	AKR1C1 AKR1C2	1.18e-04	4	155	2	10803568
Pubmed	AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.	AKR1C1 AKR1C2	1.18e-04	4	155	2	34590152
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	ZNF143 SETX PSMC4 SIN3A IKZF5 YEATS2 MSH6 CCZ1 UCHL3 ASNS PES1 EIF5B CTPS1 NME2 XPOT	1.31e-04	1103	155	15	34189442
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	PSD SIN3A SLC4A1 FANCD2 YEATS2 MSH6 CACTIN BRD8 ALMS1 COQ8A WRAP73 LRP1 MACF1 PADI2 BRWD1	1.49e-04	1116	155	15	31753913
Pubmed	Cholesteryl ester transfer protein (CETP) expression enhances HDL cholesteryl ester liver delivery, which is independent of scavenger receptor BI, LDL receptor related protein and possibly LDL receptor.	CETP LRP1	1.96e-04	5	155	2	17055779
Pubmed	Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.	AKR1C1 AKR1C2	1.96e-04	5	155	2	21851338
Pubmed	Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.	AKR1C1 AKR1C2	1.96e-04	5	155	2	15212687
Pubmed	Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.	AKR1C1 AKR1C2	1.96e-04	5	155	2	16984997
Pubmed	Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family.	AKR1C1 AKR1C2	1.96e-04	5	155	2	7737980
Pubmed	Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.	AKR1C1 AKR1C2	1.96e-04	5	155	2	17872381
Cytoband	10p15-p14	AKR1C1 AKR1C2	1.68e-04	6	155	2	10p15-p14
GeneFamily	Parkinson disease associated genes\|Ubiquitin C-terminal hydrolases	BAP1 UCHL3	1.99e-04	4	105	2	998
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	OPHN1 ARHGAP29 ARHGAP25 ARHGAP20	2.01e-04	50	105	4	721
Coexpression	GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP	ATP7A TMEM135 TBC1D2B SIN3A OPHN1 POLR3E PUS7 BRWD1	1.23e-05	181	154	8	M6849
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_DN	AHI1 AKR1C1 AKR1C2 ASNS	1.32e-05	25	154	4	MM480
Coexpression	GSE10094_LCMV_VS_LISTERIA_IND_EFF_CD4_TCELL_UP	LRRC8C MAN2A2 BMS1 ZFC3H1 SHPRH UBR3 ARHGAP25 BRWD1	2.43e-05	199	154	8	M3046
Coexpression	GSE5503_LIVER_DC_VS_SPLEEN_DC_ACTIVATED_ALLOGENIC_TCELL_DN	POGLUT3 PRXL2B PIR FANCM FANCD2 NETO2 ARHGAP25 CTPS1	2.52e-05	200	154	8	M6997
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	NAPEPLD MSH6 NDC1 SHPRH MACF1 TTC17 TMEM68 VCAM1	2.86e-07	186	154	8	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	COL4A2 TBKBP1 CETP ADORA2A-AS1 SMPDL3B HMCN1 ARHGAP29 PRKG1	4.78e-07	199	154	8	1295f34a350bf48987e2fad411aaac3630efd3f1
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	COL4A2 SETX MPDZ AGO4 HMCN1 ARHGAP29 MACF1 BRWD1	4.96e-07	200	154	8	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL4A2 LRRC8C PRXL2B YEATS2 BRD8 ARHGAP29 VCAM1	4.21e-06	188	154	7	524d1d928c9386acf20e53d31894107dd7290dc7
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL4A2 LRRC8C PRXL2B YEATS2 BRD8 ARHGAP29 VCAM1	4.21e-06	188	154	7	1b57995d70cf81212e8d46dfaf44dbaf9c7bc4d5
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL4A2 LRRC8C PRXL2B YEATS2 BRD8 ARHGAP29 VCAM1	4.21e-06	188	154	7	cd2d1f8e43c252dd8730a5758458ef63e7ffc836
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL4A2 LRRC8C PRXL2B YEATS2 BRD8 ARHGAP29 VCAM1	4.21e-06	188	154	7	f5a2f324f3f6c5078d57130392d3f1ba74f29094
ToppCell	5'-Airway_Nasal-Endothelial\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL4A2 LRRC8C PRXL2B YEATS2 BRD8 ARHGAP29 VCAM1	4.21e-06	188	154	7	6c9d5e4014f807149328ff4eabd5e86dfe18094d
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	GPAT3 PKDREJ SAG DNAH12 VASH2	5.12e-06	72	154	5	7877184d5c9dd6d96476d71e7504e58c0b4d0f26
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDH26 TBKBP1 PIR STAB1 HMCN1 VCAM1 EPHA7	5.53e-06	196	154	7	e386526332138e636aef2542c11316347a45689c
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DYNC2I1 MEIS3 DNAI3 LRP1 MACF1 ARHGAP20 VCAM1	5.72e-06	197	154	7	fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 IQCH DYNC2I1 MPDZ CFAP43 DNAI3 DNAH12	5.72e-06	197	154	7	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	15-Distal-Epithelial-Multiciliated_precursor\|Distal / Age, Tissue, Lineage and Cell class	CFAP47 CDH26 IQCH CFAP43 DNAI3 DNAH12	2.55e-05	167	154	6	442ea71a581ed5a547a214132b9f1b0243fd0895
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL4A2 MPDZ FAM217A PRDM11 SARDH ARHGAP20	2.55e-05	167	154	6	55c3c68af269fcf40f2b080ae4489523609ad388
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 ADAMTS2 MEIS3 HMCN1 LRP1 PRKG1	3.42e-05	176	154	6	9bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 ADAMTS2 MEIS3 HMCN1 LRP1 PRKG1	3.42e-05	176	154	6	3f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 PRXL2B MMP24 AGMO LRP1 VCAM1	3.53e-05	177	154	6	26bad614560609d318bfc9c235a698bca4e1c22c
ToppCell	3'_v3-lymph-node_spleen-Mast-Mast_cell_lympho\|lymph-node_spleen / Manually curated celltypes from each tissue	GPAT3 SI GCNT7 COQ8A LRP1 DNAH8	3.53e-05	177	154	6	53040dbeb18574a48e352e4bce252c7c3018762c
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS2 GSTM2 NKAIN4 MACF1 ARHGAP20 VCAM1	3.76e-05	179	154	6	948c2a01ec7a626c68281e6e796a9f0527a88591
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	C5orf67 KHDRBS2 OR2T11 AGMO VCAM1 EPHA7	3.76e-05	179	154	6	58ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC4A1 TMED3 ASNS EIF5B NME2 VCAM1	3.88e-05	180	154	6	54e3f289a37d4cfbfca4fb284c3b52e9c7d9da97
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC4A1 TMED3 ASNS EIF5B NME2 VCAM1	3.88e-05	180	154	6	bfc8568d57034dd9c9e07edae94479a48ca0706d
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	GSTM2 NEO1 NKAIN4 LRP1 MACF1 VCAM1	4.13e-05	182	154	6	ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBKBP1 STAB1 PRDM11 HMCN1 VCAM1 EPHA7	4.25e-05	183	154	6	b0b5a41f1a40f9c946d0dc8b67eaccdd9f9b73a5
ToppCell	15-Trachea-Epithelial-Multiciliated_precursor\|Trachea / Age, Tissue, Lineage and Cell class	POGLUT3 AHI1 RTTN SAG DNAH12 NETO2	4.52e-05	185	154	6	9a8b8360d99375b726ca8e3c9a3f9b08919892d7
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	NAPEPLD NDC1 SHPRH MACF1 TTC17 TMEM68	4.52e-05	185	154	6	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	facs-Limb_Muscle-Muscle_Diaphragm-18m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHIA TMED3 GSTM2 NKAIN4 CPQ LRP1	4.66e-05	186	154	6	a66da8453bb78f7e9f5f59452b3c50ae679d83c3
ToppCell	droplet-Kidney-nan-18m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK3 FOLH1 DAO OXCT1 COQ8A SARDH	4.80e-05	187	154	6	236e9857729670e87eed30fad58f49e1f56e4a85
ToppCell	P15-Mesenchymal\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAMTS2 NKAIN4 CPQ LRP1 MACF1 VCAM1	4.94e-05	188	154	6	f1ba0b661621a65c91432e62ba73531bdf18e7c1
ToppCell	E16.5-samps-Mesenchymal\|E16.5-samps / Age Group, Lineage, Cell class and subclass	GSTM2 NEO1 NKAIN4 LRP1 MACF1 VCAM1	4.94e-05	188	154	6	3f0f662be684e3a4c6652e636cc135a39a1d2790
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-SMG_serous_secreting_cell-SMG_serous_(nasal)-SMG_serous_(nasal)_L.0.6.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BPIFB3 FOLH1 C2orf88 TMED3 HPR PADI2	5.09e-05	189	154	6	29423dc66a8af71293b2e1670acc6c34dfe63608
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPST1 ADAMTS2 PCDHB18P NEO1 HMCN1 SARDH	5.09e-05	189	154	6	d00410010283dc6191ce9857d6c7952678fed588
ToppCell	facs-Diaphragm-Limb_Muscle-18m-Mesenchymal-mesenchymal_stem_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPST1 C2orf88 PIR TMED3 CPQ LRP1	5.09e-05	189	154	6	dde037322c8caec0c04c5be1c1b59a167824ad9f
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 CETP AKR1C1 AKR1C2 ARHGAP29 UBR3	5.24e-05	190	154	6	32400c62cb9de4c2b24af4206c21a0215ab12212
ToppCell	PND07-28-samps-Mesenchymal-Matrix_fibroblast-FB-3\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	GSTM2 NEO1 NKAIN4 HMCN1 MACF1 VCAM1	5.24e-05	190	154	6	1196b8ea2c44c7c80f5ee589dd517e6a413f2077
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-SMG_serous_secreting_cell-SMG_serous_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BPIFB3 FOLH1 C2orf88 TMED3 HPR PADI2	5.24e-05	190	154	6	e3a07dcffb75375693738bef1668353f4cdba5d7
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS2 DNAI3 LRP1 PRKG1 ARHGAP20 VCAM1	5.24e-05	190	154	6	45df8fee00f8949937863159d7aa042e72748d9b
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-SMG_serous_secreting_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BPIFB3 FOLH1 C2orf88 TMED3 HPR PADI2	5.24e-05	190	154	6	f6f8451eef5a387b0a1fd2e90ab965928ea2ea82
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTS2 GSTM2 CPQ LRP1 MACF1 VCAM1	5.40e-05	191	154	6	44a9a6768084dafc641ad455b65862bfd4cc0cb9
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal\|E16.5-samps / Age Group, Lineage, Cell class and subclass	GSTM2 NEO1 NKAIN4 LRP1 MACF1 VCAM1	5.40e-05	191	154	6	3379d145d34f89150f7b06d1340022cfc6b4a6ce
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAMTS2 NEO1 NKAIN4 LRP1 MACF1 VCAM1	5.40e-05	191	154	6	a05e9a7eb137d804570dd7d8905975d735738767
ToppCell	10x5'v1-week_17-19-Endothelial-stroma-proliferating_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	COL4A2 STAB2 FOLH1 HMCN1 ARHGAP29 VCAM1	5.40e-05	191	154	6	dc9e5eb6aa31b8d79aeec33e59b9138dfb469a3b
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBKBP1 PIR STAB1 HMCN1 VCAM1 EPHA7	5.55e-05	192	154	6	0b9b2eaed45456d7d74ce78a64ef4a26ac2458fb
ToppCell	facs-Heart-LA-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIR STAB1 NKAIN4 HMCN1 VCAM1 EPHA7	5.55e-05	192	154	6	14a816ef116aa992f86edab411f043cf7d07fe04
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS2 DNAI3 LRP1 PRKG1 ARHGAP20 VCAM1	5.55e-05	192	154	6	f4fc2b0121f879bab2bee99dfb5ff2c3ca1c0e1b
ToppCell	facs-Heart-LA-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIR STAB1 NKAIN4 HMCN1 VCAM1 EPHA7	5.55e-05	192	154	6	847822514d747a21d5eb40e04ba9a023fd32bd65
ToppCell	PND28-Mesenchymal-Mesenchymal_structural\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS2 NEO1 CPQ LRP1 MACF1 VCAM1	5.72e-05	193	154	6	ec81c1afdae2e0433a22c8c1fa1c6232526ff7e7
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP47 ANK3 DYNC2I1 CFAP43 DNAI3 GSTM2	5.72e-05	193	154	6	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CFAP47 IQCH DYNC2I1 CFAP43 DNAI3 DNAH12	5.72e-05	193	154	6	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TPST1 ADAMTS2 NKAIN4 CPQ LRP1 VCAM1	5.72e-05	193	154	6	e27885a9e1a2a3e165c5366d4cfcda05c5454483
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS2 NEO1 CPQ LRP1 MACF1 VCAM1	5.72e-05	193	154	6	30481fb01c7acf85beae10213f038da86bed6777
ToppCell	10x5'v1-week_17-19-Endothelial\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	COL4A2 STAB2 MPDZ HMCN1 ARHGAP29 VCAM1	5.88e-05	194	154	6	e141beafc9252e5d8c949252bfab53e127c881dc
ToppCell	10x5'v1-week_17-19-Endothelial-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	COL4A2 STAB2 MPDZ HMCN1 ARHGAP29 VCAM1	5.88e-05	194	154	6	953578102ffc7b612ee8fce45e414750800fef5d
ToppCell	PND07-28-samps-Mesenchymal\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ADAMTS2 GSTM2 NEO1 NKAIN4 HMCN1 CPQ	5.88e-05	194	154	6	68bcc1fe8dc8d5f23a12154fc9b41362fdef0b1d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 AKR1C1 AKR1C2 CNTN5 VCAM1 EPHA7	5.88e-05	194	154	6	8ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCell	moderate-Epithelial-FOXN4+\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	POGLUT3 AHI1 RTTN NDC1 ALMS1 NETO2	5.88e-05	194	154	6	dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POGLUT3 ADAMTS2 NEO1 NKAIN4 MACF1 VCAM1	6.05e-05	195	154	6	cbe518b465b4ef32797ae6b608219207c08493df
ToppCell	10x5'v1-week_17-19-Endothelial-stroma-sinusoidal_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	COL4A2 STAB2 MPDZ HMCN1 ARHGAP29 VCAM1	6.05e-05	195	154	6	22a481927147ec4ae9d59e6af7c87df0e9cb51e4
ToppCell	PND03-Mesenchymal-Mesenchymal_structural\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POGLUT3 ADAMTS2 NEO1 NKAIN4 MACF1 VCAM1	6.05e-05	195	154	6	136b06b0931a69b1241101f68c01c44c70365fd9
ToppCell	RA-02._Fibroblast_II\|RA / Chamber and Cluster_Paper	COL4A2 PIR AKR1C1 AKR1C2 OPHN1 LRP1	6.05e-05	195	154	6	6a02ebbeb3199447ddce64d92d8809436e040eba
ToppCell	P03-Mesenchymal\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAMTS2 NEO1 NKAIN4 LRP1 MACF1 VCAM1	6.05e-05	195	154	6	6180309c6ae278b996fd98c57461cbc129c028ba
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIR STAB1 HMCN1 CTPS1 VCAM1 EPHA7	6.23e-05	196	154	6	7d5eaed189aa6116f3799be010139fb675ec65e0
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	CFAP47 ANK3 MPDZ CFAP43 DNAH12 MACF1	6.23e-05	196	154	6	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS2 GSTM2 NKAIN4 LRP1 MACF1 VCAM1	6.23e-05	196	154	6	97e26622d9582b092c18ff5b7e957818f99d9631
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A2 ADAMTS2 LRP1 ARHGAP20 VCAM1 EPHA7	6.23e-05	196	154	6	2ab9735aa7a7e95dcf6b0bdf0427f7b57f6349ee
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS2 GSTM2 NKAIN4 LRP1 MACF1 VCAM1	6.23e-05	196	154	6	617103f4a09e009fe96c28eb5e40505a4fd6dcf4
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS2 GSTM2 NKAIN4 LRP1 MACF1 VCAM1	6.23e-05	196	154	6	f429f045ba45e24717963315832150b12a115bfa
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POGLUT3 ADAMTS2 NEO1 NKAIN4 MACF1 VCAM1	6.23e-05	196	154	6	2a885eed52f9b002c7995e11e450c7e8d7ae69e6
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POGLUT3 ADAMTS2 NEO1 NKAIN4 MACF1 VCAM1	6.23e-05	196	154	6	14246f00c90741a5f8683f377e22e3a7c99661b9
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS2 GSTM2 NKAIN4 LRP1 MACF1 VCAM1	6.23e-05	196	154	6	db64ab27374f82553ee577aec056141170f3656f
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	CFAP47 ANK3 MPDZ CFAP43 DNAH12 MACF1	6.23e-05	196	154	6	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIR STAB1 HMCN1 CTPS1 VCAM1 EPHA7	6.23e-05	196	154	6	dbf154b3d166ffd07be717dac8d8a3350ac63e16
ToppCell	10x3'2.3-week_14-16-Endothelial-stroma-sinusoidal_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	COL4A2 STAB2 MPDZ STAB1 ARHGAP29 VCAM1	6.40e-05	197	154	6	f1080d93acf1a4756d2f2c8cabd1fb50bc7bcd09
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma-sinusoidal_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	COL4A2 STAB2 MPDZ STAB1 HMCN1 ARHGAP29	6.40e-05	197	154	6	4e58bbf3ecb30b4c8199adcc04d2eb134d90de56
ToppCell	Control_saline\|World / Treatment groups by lineage, cell group, cell type	SETX MPDZ NKAIN4 HMCN1 ARHGAP29 MACF1	6.77e-05	199	154	6	11c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DNAI3 LRP1 MACF1 PRKG1 ARHGAP20 VCAM1	6.77e-05	199	154	6	a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCell	Parenchymal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	C2orf88 AKR1C1 AKR1C2 CCZ1 ASNS VCAM1	6.77e-05	199	154	6	6f5ef959b51eccf1ffc2e5ddf0d83c62ca2257b2
ToppCell	Parenchymal-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	C2orf88 AKR1C1 AKR1C2 CCZ1 ASNS VCAM1	6.77e-05	199	154	6	1aa99d21bf61b86df4a966dc47634044430aa39f
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	COL4A2 LRP1 MACF1 PRKG1 ARHGAP20 VCAM1	6.77e-05	199	154	6	30d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	ANK3 AKR1C1 AKR1C2 OPHN1 ASNS VASH2	6.96e-05	200	154	6	84e4565d28a02700bf7f6730d1b3a58744ca0aea
ToppCell	10x5'v1-week_14-16-Endothelial-stroma-sinusoidal_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	COL4A2 STAB2 MPDZ STAB1 ARHGAP29 VCAM1	6.96e-05	200	154	6	ae429f2de652cc1976e63644781197e9ce0e70c8
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_only / Treatment groups by lineage, cell group, cell type	COL4A2 DNAI3 LRP1 MACF1 PRKG1 ARHGAP20	6.96e-05	200	154	6	a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	AHI1 NAPEPLD DNAI3 DNAH12 DNAH8	1.75e-04	150	154	5	53de595376a9fc92491dfd58ff25938b0bf79903
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	AHI1 NAPEPLD DNAI3 DNAH12 DNAH8	1.75e-04	150	154	5	e4b40b3243ed26d0c46bf196ac06e148834e7ed2
ToppCell	367C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PPARD SLC4A1 HSPA6 VCAM1	2.06e-04	84	154	4	fedccab997a8ca298b97240e1db1683cdf56140b
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	CFAP47 MPDZ CFAP43 DNAH12 CNTN5	2.10e-04	156	154	5	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	Goblet\|World / Class top	C2orf88 TMPRSS5 TMED3 SMPDL3B PADI2	2.16e-04	157	154	5	b352aa37d662629db6a9c6def9ee6d7c49a9071c
ToppCell	NS-moderate-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP47 POGLUT3 RTTN DNAH12 ALMS1	2.16e-04	157	154	5	410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell	Goblet-gob-1\|World / Class top	C2orf88 TMPRSS5 TMED3 SMPDL3B PADI2	2.29e-04	159	154	5	62d4ca2b538382419252e306d7a789b64420fb18
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FANCM IL18RAP SLC4A1 COX5A PADI2	2.29e-04	159	154	5	95128a2367ff2a639b21913c0350924c174faef8
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1\|E16.5-samps / Age Group, Lineage, Cell class and subclass	ADAMTS2 PCDHGA6 GSTM2 LRP1 MACF1	2.57e-04	163	154	5	f1ec2625b52664308968b01d8e0275e1e0751480
ToppCell	Severe-Lymphoid-NK-CCR7+_T\|Severe / Condition, Lineage, Cell class and cell subclass	ANK3 USP46 IL18RAP IKZF5 PRDM11	2.57e-04	163	154	5	8f0d8c124f1569a5a6bc1db7581989f24d63cca3
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Alveolar_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TBC1D2B GPAT3 LRP1 ARHGAP20 VCAM1	2.79e-04	166	154	5	65dafed953b01a9830b54309af75c7a561e88336
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CDH26 ANK3 CFAP43 AKR1C1 AKR1C2	2.79e-04	166	154	5	1df4bdf7c773cbfa6c93d7a901f9cd3f3fe07a3d
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CDH26 ANK3 CFAP43 AKR1C1 AKR1C2	2.79e-04	166	154	5	9628522e7af8f8edca733588a364ab2454ac5ca5
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KHDRBS2 AGO4 SMPDL3B NETO2 CNTN5	2.95e-04	168	154	5	b87fc63f9e35dfcfc46cb129ea569e73c5e018bb
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KHDRBS2 AGO4 SMPDL3B NETO2 CNTN5	2.95e-04	168	154	5	b96a48552f4236a95bbcdce2f1b05041086d7101
ToppCell	facs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBKBP1 DAO STAB1 HMCN1 PRKG1	2.95e-04	168	154	5	06dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCell	facs-Heart-RA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBKBP1 DAO STAB1 HMCN1 PRKG1	2.95e-04	168	154	5	1002f058a340763e3d8de0bd1f0547a903526ec6
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A2 ADAMTS2 CFHR4 ARHGAP20 EPHA7	3.03e-04	169	154	5	c0824a93674e2bff0f09b2d2fab5bab016a2e379
Disease	laryngeal squamous cell carcinoma, hypopharynx cancer	RTTN AKR1C1	2.67e-05	2	153	2	EFO_0006352, EFO_0007321
Disease	interferon alpha measurement	CHIA TMPRSS5 PRKG1	2.91e-05	12	153	3	EFO_0006517
Disease	Neoplasms, Hormone-Dependent	AKR1C1 AKR1C2	7.99e-05	3	153	2	C0027661
Disease	testosterone measurement	COL4A2 C5orf67 ANK3 DAO SIN3A PKDREJ AKR1C2 OPHN1 FARP2 GSTM2 MSH6 HMCN1 AGMO PPA2 ANKDD1B MACF1 CTPS1 BRWD1	1.14e-04	1275	153	18	EFO_0004908
Disease	marginal zone B- and B1-cell-specific protein measurement	DNAH12 PROB1	1.59e-04	4	153	2	EFO_0802730
Disease	apolipoprotein B measurement	COL4A2 HBS1L C5orf67 TBKBP1 PSD CETP ZNF101 FARP2 GSTM2 HPR ANKDD1B BRWD1	1.86e-04	663	153	12	EFO_0004615
Disease	Sarcosine measurement	PCDHGA6 CNTN5 SARDH	2.24e-04	23	153	3	EFO_0021668
Disease	Hermaphroditism	AKR1C1 AKR1C2	2.64e-04	5	153	2	C0019269
Disease	Ambiguous Genitalia	AKR1C1 AKR1C2	2.64e-04	5	153	2	C0266362
Disease	Pseudohermaphroditism	AKR1C1 AKR1C2	2.64e-04	5	153	2	C0033804
Disease	Intersex Conditions	AKR1C1 AKR1C2	2.64e-04	5	153	2	C2930618
Disease	Sex Differentiation Disorders	AKR1C1 AKR1C2	2.64e-04	5	153	2	C2930619
Disease	Disorders of Sex Development	AKR1C1 AKR1C2	5.51e-04	7	153	2	C0036875
Disease	migraine disorder	NSD1 HAUS1 CPQ LRP1 ANKDD1B MACF1 PRKG1 TMEM68	5.74e-04	357	153	8	MONDO_0005277
Disease	platelet component distribution width	HBS1L C5orf67 AHI1 NUP210L RTTN SIN3A ACSL3 BRD8 CNTN5 ANKDD1B MACF1 BRWD1	5.97e-04	755	153	12	EFO_0007984
Disease	restless legs syndrome (implicated_via_orthology)	MEIS3 MEIS3P2	7.33e-04	8	153	2	DOID:0050425 (implicated_via_orthology)
Disease	Fanconi anemia (implicated_via_orthology)	FANCM FANCD2	7.33e-04	8	153	2	DOID:13636 (implicated_via_orthology)
Disease	triglycerides:total lipids ratio, low density lipoprotein cholesterol measurement	C5orf67 CETP LACTB ANKDD1B MACF1	1.14e-03	150	153	5	EFO_0004611, EFO_0020947
Disease	lipid measurement, lipoprotein measurement	TBKBP1 CETP PPARD HPR	1.26e-03	90	153	4	EFO_0004529, EFO_0004732
Disease	colitis (biomarker_via_orthology)	SI HPR VCAM1	1.35e-03	42	153	3	DOID:0060180 (biomarker_via_orthology)
Disease	N-acetylphenylalanine measurement	ALMS1 DUSP11	1.42e-03	11	153	2	EFO_0800019
Disease	Malignant Head and Neck Neoplasm	FANCM BAP1 FANCD2	1.55e-03	44	153	3	C0278996
Disease	concentration of large LDL particles measurement	TBKBP1 CETP HPR	1.55e-03	44	153	3	EFO_0022160
Disease	cholesterol in medium VLDL measurement	TBKBP1 CETP HPR	1.55e-03	44	153	3	EFO_0022225
Disease	apolipoprotein A 1 measurement	C5orf67 MAN2A2 CETP NSD1 PPARD LACTB STAB1 FARP2 GSTM2 LRP1 MACF1 TMEM151A	1.61e-03	848	153	12	EFO_0004614
Disease	calcium measurement	KHDRBS2 TBC1D2B ZNF101 SLC4A1 FARP2 SAG COX5A PPA2 MACF1 PRKG1	1.68e-03	628	153	10	EFO_0004838
Disease	pulmonary embolism (biomarker_via_orthology)	HPR VCAM1	1.70e-03	12	153	2	DOID:9477 (biomarker_via_orthology)
Disease	free cholesterol in small VLDL measurement	TBKBP1 CETP HPR	1.88e-03	47	153	3	EFO_0022272
Disease	iron deficiency anemia (biomarker_via_orthology)	ATP7A SLC4A1	2.01e-03	13	153	2	DOID:11758 (biomarker_via_orthology)
Disease	apolipoprotein B to apolipoprotein A1 ratio	CETP GSTM2 HPR	2.11e-03	49	153	3	EFO_0021897
Disease	cholesterol in small LDL measurement	TBKBP1 CETP HPR	2.11e-03	49	153	3	EFO_0022227
Disease	cholesteryl ester measurement	C5orf67 TBKBP1 CETP GSTM2 HPR ANKDD1B	2.29e-03	257	153	6	EFO_0010351
Disease	Hermansky-Pudlak syndrome (implicated_via_orthology)	CCZ1B CCZ1	2.33e-03	14	153	2	DOID:3753 (implicated_via_orthology)
Disease	apolipoprotein A 1 measurement, apolipoprotein B measurement	C5orf67 TBKBP1 CETP HPR	2.37e-03	107	153	4	EFO_0004614, EFO_0004615
Disease	Intellectual Disability	AHI1 RTTN TMEM135 NSD1 SIN3A AGMO MACF1 PUS7	2.39e-03	447	153	8	C3714756
Disease	very low density lipoprotein cholesterol measurement	C5orf67 TBKBP1 CETP HPR CNTN5 BRWD1	2.43e-03	260	153	6	EFO_0008317
Disease	total blood protein measurement	COL4A2 TBC1D2B TMPRSS5 PPARD SLC4A1 PPA2 ARHGAP29 MACF1	2.46e-03	449	153	8	EFO_0004536
Disease	N-acetylmethionine measurement	ALMS1 EPHA7	2.68e-03	15	153	2	EFO_0021427
Disease	total lipids in medium VLDL	C5orf67 CETP HPR	2.79e-03	54	153	3	EFO_0022153
Disease	triglycerides in medium VLDL measurement	C5orf67 CETP HPR	2.94e-03	55	153	3	EFO_0022155
Disease	leukemia	BAP1 FANCD2 MSH6	2.94e-03	55	153	3	C0023418
Disease	low density lipoprotein cholesterol measurement, lipid measurement	TBKBP1 CETP HPR BRWD1	2.98e-03	114	153	4	EFO_0004529, EFO_0004611
Disease	5-oxoproline measurement	PRKG1 DNAH8	3.06e-03	16	153	2	EFO_0010988
Disease	gastroparesis	CFAP43 PRKG1	3.06e-03	16	153	2	EFO_1000948
Disease	response to methotrexate	AKR1C1 AKR1C2	3.06e-03	16	153	2	GO_0031427
Disease	cytochrome-c oxidase deficiency disease (implicated_via_orthology)	COA8 COX5A	3.45e-03	17	153	2	DOID:3762 (implicated_via_orthology)
Disease	low density lipoprotein cholesterol measurement, phospholipid measurement	TBKBP1 CETP HPR BRWD1	3.58e-03	120	153	4	EFO_0004611, EFO_0004639
Disease	phospholipids in VLDL measurement	C5orf67 CETP HPR	3.59e-03	59	153	3	EFO_0022301
Disease	phospholipids in small VLDL measurement	C5orf67 CETP HPR	3.77e-03	60	153	3	EFO_0022146
Disease	total lipids in VLDL measurement	C5orf67 CETP HPR	3.77e-03	60	153	3	EFO_0022314
Disease	cholesterol to total lipids in IDL percentage	C5orf67 ANKDD1B MACF1	3.77e-03	60	153	3	EFO_0022233
Disease	free cholesterol to total lipids in medium HDL percentage	C5orf67 CETP ANKDD1B	3.77e-03	60	153	3	EFO_0022282
Disease	atrophic macular degeneration, age-related macular degeneration, wet macular degeneration	CETP AKR1C1 CFHR4	3.77e-03	60	153	3	EFO_0001365, EFO_0004683, EFO_1001492
Disease	Bone marrow hypocellularity	FANCM FANCD2	3.87e-03	18	153	2	C1855710
Disease	free cholesterol in VLDL measurement	C5orf67 CETP HPR	3.95e-03	61	153	3	EFO_0022276
Disease	lymphocyte count	LRRC8C HBS1L PCDHGA6 NSD1 NME2P1 PPARD IL18RAP SLC4A1 SAG ALMS1 CNTN5 VASH2 PPA2 HSF2 HSPA6 VCAM1	3.97e-03	1464	153	16	EFO_0004587
Disease	free cholesterol in very large HDL measurement	C5orf67 CETP ANKDD1B	4.13e-03	62	153	3	EFO_0022273
Disease	C-reactive protein measurement	C5orf67 ANK3 FOLH1 NUP210L CETP NME2P1 IL18RAP SIRT4 FARP2 YEATS2 NEO1 HPR MACF1 EPHA7	4.14e-03	1206	153	14	EFO_0004458
Disease	melanoma	COL4A2 POGLUT3 FARP2 MMP24	4.26e-03	126	153	4	EFO_0000756
Disease	cytochrome-c oxidase deficiency disease (is_implicated_in)	COA8 COX5A	4.31e-03	19	153	2	DOID:3762 (is_implicated_in)
Disease	blood metabolite measurement	ALMS1 SARDH	4.31e-03	19	153	2	EFO_0005664
Disease	leukemia (implicated_via_orthology)	MEIS3 MEIS3P2	4.31e-03	19	153	2	DOID:1240 (implicated_via_orthology)
Disease	triglycerides:total lipids ratio, intermediate density lipoprotein measurement	C5orf67 LACTB ANKDD1B MACF1	4.39e-03	127	153	4	EFO_0008595, EFO_0020947
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	CYP8B1 SIRT4 HPR	4.72e-03	65	153	3	DOID:0080208 (biomarker_via_orthology)
Disease	cholesterol in large VLDL measurement	C5orf67 CETP HPR	4.72e-03	65	153	3	EFO_0021902
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Positive	C2orf88 ZFC3H1 STAB1 HSPA6	4.89e-03	131	153	4	C4704862
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Negative	C2orf88 ZFC3H1 STAB1 HSPA6	4.89e-03	131	153	4	C4552091
Disease	Juvenile arthritis	C2orf88 ZFC3H1 STAB1 HSPA6	4.89e-03	131	153	4	C3495559
Disease	Juvenile psoriatic arthritis	C2orf88 ZFC3H1 STAB1 HSPA6	4.89e-03	131	153	4	C3714758
Disease	Epstein-Barr virus infection	KHDRBS2 TMED3 CPQ	4.93e-03	66	153	3	EFO_0000769
Disease	total lipids in very large HDL measurement	C5orf67 CETP ANKDD1B	4.93e-03	66	153	3	EFO_0022312
Disease	phospholipids in very large HDL measurement	C5orf67 CETP ANKDD1B	4.93e-03	66	153	3	EFO_0022298
Disease	total lipids in small VLDL	C5orf67 CETP HPR	5.14e-03	67	153	3	EFO_0022148
Disease	Microcephaly	SIN3A AGMO PUS7	5.14e-03	67	153	3	C0025958

Protein segments in the cluster

Peptide	Gene	Start	Entry
PVVPLEEGLNKAIHY	UXS1	376	Q8NBZ7
FLLEIIVKHGEPAPY	TPST1	141	O60507
KVEPFLPGHYEVLDL	ASNS	176	P08243
LPANIHVLFYVPKGT	BPIFB3	356	P59826
HVLFYVPKGTPESLF	BPIFB3	361	P59826
SEIPGHQVDILYKLF	CFAP43	1296	Q8NDM7
GHFIYKNVSEDLPLP	CETP	251	P11597
HTGIQEYQDGVPKIP	CPQ	216	Q9Y646
FVLLGPEAPHIDYTQ	SLC4A1	266	P02730
VFLQPVTDDIAPGYH	BRD8	731	Q9H0E9
TEFKGIPISYLEIHP	AHI1	796	Q8N157
KVVYGLTHPINTFEP	AGMO	256	Q6ZNB7
GQAPLYPIVHVTELK	ADORA2A-AS1	21	P86434
EKPGIFYQQTLPESH	ALMS1	1101	Q8TCU4
FYQQTLPESHLPKEA	ALMS1	1106	Q8TCU4
HTEKPGIFYQQVLPD	ALMS1	1241	Q8TCU4
HTEKPGVFYQQVLPH	ALMS1	1336	Q8TCU4
YKQAFPEGHLPEESL	ALMS1	1486	Q8TCU4
YKQAFPDGHLPEEAL	ALMS1	1581	Q8TCU4
PAEKLIVGFPTYGHN	CHIA	256	Q9BZP6
IIAPTGVTFHPDQYK	COL4A2	261	P08572
FELDGLKVYPIDHGP	BAP1	181	Q92560
YPTRKPFHQENGDVI	ADAM32	556	Q8TC27
VSLNKEIYFHGEPIP	SAG	211	P10523
GPDPYLKEFGIVVHN	AGO4	381	Q9HCK5
DFHPVKKIVQEYPGN	DNAI3	86	Q8IWG1
EFVQNFDPHYPIILG	BMS1	896	Q14692
GEHLPNTYVDLTKDP	CASP8AP2	1676	Q9UKL3
PETNAVDEPYKIHGL	ADAMTS2	1156	O95450
TNKAHIKYDPEIIGP	ATP7A	601	Q04656
GEYEPKIEVHFPFTV	CNTN5	296	O94779
QNHIPIEPDYKFSTL	NSD1	896	Q96L73
YFTPIPVLQADAHKG	IQCH	156	Q86VS3
LIEHFGKIYLGPPEE	OPHN1	556	O60890
EIPITKGFPVLLHYQ	HBS1L	591	Q9Y450
KGFPVLLHYQTVSEP	HBS1L	596	Q9Y450
LISGYNLFHEAIPDP	DAO	91	P14920
HPISGEVYLKAPLDF	PCDHB18P	241	Q96TA0
HYIDLKDRPFFPGLV	NME2	51	P22392
QKVTPLTFEEVPYHE	MMP24	196	Q9Y5R2
FKEVTVEPGYPHSLG	MMP24	451	Q9Y5R2
DVQSEAHGPKYPELV	PCDHGA6	181	Q9Y5G7
YFQEPESLPHLVKKA	IL18RAP	516	O95256
EDYPRTGEHQPLKVF	PRAMEF17	136	Q5VTA0
VHNKVDLVPGYSPTE	GTPBP6	416	O43824
KPPEIANGYVEHLFR	HPR	36	P00739
TPEYVAPEIILNKGH	PRKG1	521	Q13976
KSEPVHPFGLAVYGE	LRP1	2416	Q07954
VYIVGHVPPGFFEKT	SMPDL3B	231	Q92485
GKLDLDIPVQHYVPE	LACTB	181	P83111
FITHGVYEPEKPSRN	FANCM	641	Q8IYD8
SIPVHPIGYYDAQKL	FOLH1	291	Q04609
VKFLPSDPNHFIIGT	DYNC2I1	866	Q8WVS4
KHLPYYTIIQDGTEP	FAT2	2071	Q9NYQ8
QLFGLPVTDYEVLHK	DNAH8	1256	Q96JB1
VYIGPDDAQQKIEPH	PIR	201	O00625
DFPNLPYLIDGTHKI	GSTM2	56	P28161
FPGIKLPEADYHEFL	DNAH12	1481	Q6ZR08
QKHPEDVLSYPQLFA	SLC25A20	101	O43772
EKDEIYGHPLFPLLA	MEIS3	56	Q99687
GYIEAPHKGFPVVLD	PADI2	356	Q9Y2J8
VAHYPPVQVLFEKGN	MSH6	586	P52701
PEHPNGVITEYEIKY	EPHA7	466	Q15375
VQKPDYLNDFTHEIP	IKZF5	206	Q9H5V7
DEYQTSPPKVVEIGH	MACF1	2001	Q9UPN3
KNFHLNVYVPPSIEG	HMCN1	3141	Q96RW7
DKDEIYGHPLFPLLA	MEIS3P2	56	A8K0S8
FYKPHAPIISIRGNE	ARHGAP29	1166	Q52LW3
LKELDSPVPGYQHTI	PIKFYVE	1296	Q9Y2I7
VLAVHPDKAAGQPYE	GAK	1271	O14976
FKEPEHGYQSLPELV	C5orf67	16	F2Z3F1
VPYLKIFTVGHQVPD	DUSP11	156	O75319
QSHLEFVPKGSIYAP	GCNT7	246	Q6ZNI0
EIGGTIHPVAIKYNP	GPAT3	321	Q53EU6
PREGQEENKILFYHP	CCZ1	36	P86791
PREGQEENKILFYHP	CCZ1B	36	P86790
LLKGHPFFYVPEIVD	COQ8A	421	Q8NI60
GHVEEPASPLAAYQK	ANK3	4291	Q12955
FLVDVDGNPHPTKYQ	BRWD1	591	Q9NSI6
VKPCDFPEIQHGGLY	CFHR4	21	Q92496
KETYHFDPEAPFLQV	MAN2A2	611	P49641
YVIIIHAVDDGFPPQ	CDH26	466	Q8IXH8
PEYPGVLSDVQEGKH	DHFR2	161	Q86XF0
LHVLIEVFAPPGEAY	KHDRBS2	131	Q5VWX1
SLDIEKNPHFQGPYT	LAS2	161	Q8IYD9
HAGPPYEDIAFKIVN	CACTIN	711	Q8WUQ7
YLGQPVKHAVITVPA	HSPA6	136	P17066
HPLTIASVDKQVGPY	FAM217A	126	Q8IXS0
LIKLHPEVHGPYQDT	FARP2	281	O94887
AGPHKEIYPYVIQEL	COX5A	116	P20674
ILPYDGEFIKKHPDV	POLR3E	401	Q9NVU0
KAEYHGQLPILIFPT	CFAP47	176	Q6ZTR5
GPPSVYHAAIVIFLE	MFSD14C	41	Q5VZR4
IHPEPTVFKYDRFLN	CYP8B1	396	Q9UNU6
HPSYPKIIEEFVSGL	FANCD2	86	Q9BXW9
LVPLHPGFFTLEVYD	NUP210L	951	Q5VU65
YVLPQSFHTPEQDKV	OR2T11	256	Q8NH01
VKQERDGPVEFQHPY	HSF2	81	Q03933
VNSGKEEAPYPLIGH	ARHGAP20	246	Q9P2F6
SPGDYVPKEHILQVL	PRXL2B	166	Q8TBF2
LVKYPPAVQHLVDVG	RTTN	71	Q86VV8
EIYSFPKDPEIHLSG	VCAM1	111	P19320
THFELYKQIGIDPPR	PSMC4	186	P43686
FLDLTPEPGAAVYKH	PSD	746	A5PKW4
LVNGLPPYKEISVHV	PPARD	231	Q03181
HYIDLKDRPFFPGLV	NME2P1	36	O60361
TSPHQVVKDPFYVIE	PKDREJ	821	Q9NTG1
SEVPYAGINIGPVHK	EIF5B	1001	O60841
KKIFGDHPIPQYEVN	HAUS1	16	Q96CS2
VNEVIPKGHIFGPYE	PRDM11	166	Q9NQV5
PEFLKQPTNIYAHES	NEO1	341	Q92859
LPGFDVIYPKHKIQE	PUS7	531	Q96PZ0
VGVQYHPEFLSRPIK	CTPS1	521	P17812
DKHPGIYLFLVHPNE	SETX	151	Q7Z333
VPVGPHLSLAYEDKQ	SIN3A	771	Q96ST3
TLPEGKVVNYFIPSH	SHPRH	401	Q149N8
HLKPDVVFFGDTVNP	SIRT4	226	Q9Y6E7
KTGFQEVFDPPHYEL	NETO2	386	Q8NC67
FGHPAAINDPKIVVY	WRAP73	261	Q9P2S5
EVPHQYVKEFTGPTV	SI	171	P14410
VHYQVEKLFGASSPP	TMEM151A	311	Q8N4L1
IGAFAPEDIHIPQIY	OXCT1	251	P55809
TGHYISPFHDIPLKV	PPA2	56	Q9H2U2
SVFIKDFLPVVPHPY	PROB1	681	E7EW31
IGKKHVGPETVYPFD	SGSH	121	P51688
KNYSVVFPHDEPLAG	SARDH	466	Q9UL12
VPIFEGYSLPHAVTK	ACTRT1	166	Q8TDG2
PAKQLYEELVHAGFP	ANKDD1B	491	A6NHY2
VDLYLIHFPVSVKPG	AKR1C1	111	Q04828
VDLYLIHFPVSVKPG	AKR1C2	111	P52895
YFNTDKPHPRGEILI	ACSL3	516	O95573
VHFYIPENESPLEQK	COA8	81	Q96IL0
IGGFDPFPLYHVNEK	NKAIN4	181	Q8IVV8
GDEHVAQSPYILKGP	POGLUT3	121	Q7Z4H8
QGLVPKHELSTEYIP	PDCD11	566	Q14690
YELDGRKPFPINHGE	UCHL3	181	P15374
EDGSAAYVQHVPIPK	ZNF143	81	P52747
VYTKLCGVFPPHLVE	ZC3H12A	556	Q5D1E8
EKIPEDGPALIIFYH	TMEM68	116	Q96MH6
GSPHGDLPIYVKTVF	MPDZ	2006	O75970
PHLSPFVTEKEGDYV	PES1	421	O00541
AYEQKFGPHLVPILV	ARHGAP25	166	P42331
HKTVYFDFQVGDEPP	TMED3	111	Q9Y3Q3
IEAGKVPYFPHADTI	TMEM135	366	Q86UB9
EPNHPGVYAKVAEFL	TMPRSS5	431	Q9H3S3
SHLLSVGYQVPKPEV	ZNF585B	61	Q52M93
IFPKECVYIHDPTGL	STAB1	686	Q9NY15
LQEHFVKDLVGPGPF	STAB2	1616	Q8WWQ8
VKIGLYVPHEPHSFQ	VASH2	246	Q86V25
TYFLPPENKGLRIHE	TTC17	521	Q96AE7
PFPTIYEGEKQHESE	C2orf88	11	Q9BSF0
KDIGPEQFPINEHYF	USP46	21	P62068
GKPIDYPSLFQIHVR	ZNF101	231	Q8IZC7
EILIQPEIPKYSHGD	UBR3	1116	Q6ZT12
VYKILGGFAPEHKEP	TNK1	76	Q13470
GPVGFADFVYKHIVP	XPOT	861	O43592
PFYVPHAEIERLFGK	TPMT	196	P51580
LGFPVGYPDDALIKH	TBKBP1	591	A7MCY6
PEQAFVKPHLVSEYD	TBC1D2B	581	Q9UPU7
HLIEFNILPSKFYDP	ZFC3H1	1531	O60293
HGYEELLTAKPDPAF	XRRA1	616	Q6P2D8
FFLHPSYKPNDLVEV	YEATS2	256	Q9ULM3
YLDVKGNHFEILPPE	LRRC8C	756	Q8TDW0
TFALANEHYLEPPVK	NAPEPLD	346	Q6IQ20
FKIYATEAHVFPVQP	NDC1	291	Q9BTX1