Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

ATRX LRRK2 GEM MDN1 MFN2 GNAI2 ABCG2 GNAS GNAT1 ABCC2 GNAZ KIF17 TUBB8B DNAH3 LONP2 DHX40 RNF213 ATP13A5 BTAF1 ATP10D MTREX ATP4A SMC1B

1.52e-0677519123GO:0017111
GeneOntologyMolecularFunctionpyrophosphatase activity

ATRX ENPP2 LRRK2 GEM MDN1 MFN2 GNAI2 ABCG2 GNAS GNAT1 ABCC2 GNAZ KIF17 TUBB8B DNAH3 LONP2 DHX40 RNF213 ATP13A5 BTAF1 ATP10D MTREX ATP4A SMC1B

1.68e-0683919124GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

ATRX ENPP2 LRRK2 GEM MDN1 MFN2 GNAI2 ABCG2 GNAS GNAT1 ABCC2 GNAZ KIF17 TUBB8B DNAH3 LONP2 DHX40 RNF213 ATP13A5 BTAF1 ATP10D MTREX ATP4A SMC1B

1.72e-0684019124GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

ATRX ENPP2 LRRK2 GEM MDN1 MFN2 GNAI2 ABCG2 GNAS GNAT1 ABCC2 GNAZ KIF17 TUBB8B DNAH3 LONP2 DHX40 RNF213 ATP13A5 BTAF1 ATP10D MTREX ATP4A SMC1B

1.72e-0684019124GO:0016818
GeneOntologyMolecularFunctionG-protein beta/gamma-subunit complex binding

ADORA1 GNAI2 GNAS GNAT1 GNAZ

3.46e-06251915GO:0031683
GeneOntologyMolecularFunctionATP hydrolysis activity

ATRX MDN1 ABCG2 ABCC2 KIF17 DNAH3 LONP2 DHX40 RNF213 ATP13A5 BTAF1 ATP10D MTREX ATP4A SMC1B

2.37e-0544119115GO:0016887
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of cytosolic calcium levels

CACNA1A CACNA1B CACNA1E

6.94e-0591913GO:0099511
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

CACNA1A CACNA1B CACNA1E

6.94e-0591913GO:0099626
GeneOntologyMolecularFunctionATP-dependent activity

ATRX MDN1 ABCG2 KIFC3 ABCC2 KIF17 DNAH3 LONP2 DHX40 RNF213 ATP13A5 BTAF1 ATP10D DNAH1 MTREX ATP4A SMC1B

8.96e-0561419117GO:0140657
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1A CACNA1B CACNA1E

2.90e-04141913GO:0008331
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

KIFC3 DNAH3 DNAH1

6.32e-04181913GO:0008569
GeneOntologyMolecularFunctionalkylglycerophosphoethanolamine phosphodiesterase activity

ENPP2 GNAS

8.93e-0451912GO:0047391
GeneOntologyMolecularFunctionhistone H3K27me2/H3K27me3 demethylase activity

KDM6B UTY

8.93e-0451912GO:0071558
GeneOntologyMolecularFunctionribose phosphate diphosphokinase activity

PRPS1L1 PRPS1

8.93e-0451912GO:0004749
GeneOntologyMolecularFunctionpeptide binding

MC4R SSTR2 KCNJ1 GPR171 CACNA1A CACNA1B FNTB GSAP LBR TLR2

1.01e-0331819110GO:0042277
GeneOntologyCellularComponentcytoplasmic side of membrane

PRMT8 LRRK2 GEM DST GNAI2 GNAS GNAT1 GNAZ SPPL3 THADA

5.53e-0523019210GO:0098562
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CATSPERE CACNA1A CACNA1B CACNA1E CATSPERB

6.27e-05461925GO:0005891
GeneOntologyCellularComponentCSF1-CSF1R complex

CSF1 CSF1R

8.39e-0521922GO:1990682
GeneOntologyCellularComponentheterotrimeric G-protein complex

GNAI2 GNAS GNAT1 GNAZ

2.89e-04351924GO:0005834
GeneOntologyCellularComponentGTPase complex

GNAI2 GNAS GNAT1 GNAZ

5.35e-04411924GO:1905360
GeneOntologyCellularComponentcalcium channel complex

CATSPERE CACNA1A CACNA1B CACNA1E CATSPERB

5.62e-04731925GO:0034704
GeneOntologyCellularComponentapical plasma membrane

EPS15 SLC6A19 UPK1B PKHD1 ABCG2 GNAS GNAT1 ABCC2 GP2 SLC43A1 SLC47A2 LRP2 ATP4A

5.92e-0448719213GO:0016324
GeneOntologyCellularComponentribose phosphate diphosphokinase complex

PRPS1L1 PRPS1

8.24e-0451922GO:0002189
MousePhenodecreased lean body mass

SWT1 CYP17A1 SLC6A19 MC4R ZNF202 PHKB MFN2 GNAS CCDC93 THOC1 SPPL3 FNDC3A GPRC6A CBX4 VPS13B USP33

4.53e-0640714416MP:0003961
DomainARM-type_fold

USP34 SMG1 RSPH14 NBEAL1 LRRK2 MROH5 NF1 PIK3C2G RPTOR MROH9 COPG2 BTAF1 THADA ARID2 STAG2 IPO11

4.66e-0733919216IPR016024
DomainGproteinA_insert

GNAI2 GNAS GNAT1 GNAZ

1.79e-05161924IPR011025
Domain-

GNAI2 GNAS GNAT1 GNAZ

1.79e-051619241.10.400.10
DomainG-alpha

GNAI2 GNAS GNAT1 GNAZ

1.79e-05161924PF00503
DomainG_alpha

GNAI2 GNAS GNAT1 GNAZ

1.79e-05161924SM00275
DomainGprotein_alpha_su

GNAI2 GNAS GNAT1 GNAZ

2.32e-05171924IPR001019
DomainARM-like

SMG1 RSPH14 LRRK2 MROH5 NF1 RPTOR MROH9 COPG2 BTAF1 ARID2 STAG2 IPO11

2.40e-0527019212IPR011989
DomainCa_chan_IQ

CACNA1A CACNA1B CACNA1E

3.63e-0571923SM01062
DomainCa_chan_IQ

CACNA1A CACNA1B CACNA1E

3.63e-0571923PF08763
DomainVDCC_a1su_IQ

CACNA1A CACNA1B CACNA1E

3.63e-0571923IPR014873
DomainGPHH

CACNA1A CACNA1B CACNA1E

3.63e-0571923PF16905
DomainGPHH_dom

CACNA1A CACNA1B CACNA1E

3.63e-0571923IPR031649
DomainGprotein_alpha_I

GNAI2 GNAT1 GNAZ

5.77e-0581923IPR001408
DomainTMEM183

TMEM183A TMEM183BP

1.05e-0421922IPR026509
DomainVDCCAlpha1

CACNA1A CACNA1B CACNA1E

1.22e-04101923IPR002077
DomainP-loop_NTPase

ATRX LRRK2 GEM MDN1 MFN2 GNAI2 ABCG2 KIFC3 GNAS GNAT1 ABCC2 GNAZ KIF17 DNAH3 LONP2 DHX40 RNF213 BTAF1 DNAH1 MTREX SMC1B

1.78e-0484819221IPR027417
Domain-

ATRX LRRK2 GEM MDN1 MFN2 GNAI2 ABCG2 GNAS GNAT1 ABCC2 GNAZ DNAH3 LONP2 DHX40 RNF213 BTAF1 DNAH1 MTREX SMC1B

2.58e-04746192193.40.50.300
DomainPRPP_SYNTHASE

PRPS1L1 PRPS1

3.13e-0431922PS00114
DomainPRib_PP_synth_CS

PRPS1L1 PRPS1

3.13e-0431922IPR000842
DomainATPase_dyneun-rel_AAA

MDN1 DNAH3 DNAH1

3.58e-04141923IPR011704
Domain-

SPOP SPOPL SIAH1

3.58e-041419232.60.210.10
DomainAAA_5

MDN1 DNAH3 DNAH1

3.58e-04141923PF07728
Domain-

RSPH14 LRRK2 MROH5 NF1 RPTOR MROH9 COPG2 BTAF1 IPO11

4.98e-0422219291.25.10.10
DomainSHR-BD

VPS13C VPS13B

6.22e-0441922IPR009543
DomainTF_POU_3

POU3F1 POU3F2

6.22e-0441922IPR016362
DomainVPS13_C

VPS13C VPS13B

6.22e-0441922PF16909
DomainPIN_4

SWT1 SMG6

6.22e-0441922PF13638
DomainVPS13_C

VPS13C VPS13B

6.22e-0441922IPR031645
DomainSHR-BD

VPS13C VPS13B

6.22e-0441922PF06650
DomainPribosyltran_N

PRPS1L1 PRPS1

1.03e-0351922PF13793
DomainPribosyl_synth

PRPS1L1 PRPS1

1.03e-0351922PF14572
DomainAutophagy-rel_C

VPS13C VPS13B

1.03e-0351922IPR015412
DomainATG_C

VPS13C VPS13B

1.03e-0351922PF09333
DomainRib-P_diPkinase

PRPS1L1 PRPS1

1.03e-0351922IPR005946
DomainPribosyltran_N

PRPS1L1 PRPS1

1.03e-0351922IPR029099
PathwayWP_PURINERGIC_SIGNALING

ADORA1 GNAI2 GNAS GNAT1 GNAZ

2.31e-05331495M39855
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

USP34 SMG1 TMEM183A ACADSB EIF3E GEM FASN DST MDN1 SYNE2 GNAS CCDC93 PARP12 THOC1 FXR2 VPS8 RNF213 COPG2 UFL1 BTAF1 LBR SLC1A5 THADA OASL MTREX CNOT1 STAG2 IPO11 PRPS1

2.27e-0914401942930833792
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

USP34 SMG1 VPS13C PLXND1 KDM6B DST RPTOR DNMBP SMG6 SZT2 FNDC3A UFL1 AKAP11 MTREX HERC4 CNOT1

5.57e-085291941614621295
Pubmed

Munc13-3 Is Required for the Developmental Localization of Ca2+ Channels to Active Zones and the Nanopositioning of Cav2.1 Near Release Sensors.

CACNA1A CACNA1B UNC13C

1.71e-073194329466725
Pubmed

The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.

CACNA1A CACNA1B CACNA1E

1.71e-073194338996073
Pubmed

Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.

CACNA1A CACNA1B CACNA1E

1.71e-073194324523520
Pubmed

Evolution of the mammalian G protein alpha subunit multigene family.

GNAI2 GNAS GNAT1 GNAZ CSF1R PAH

3.19e-074919461302014
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

USP34 SMG1 KIAA0232 BIRC6 DST SYNE2 SMG6 FNDC3A CDC42BPB AKAP11

6.13e-072251941012168954
Pubmed

Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.

CACNA1A CACNA1B CACNA1E

6.81e-074194332616470
Pubmed

Cerebellar granule cell signaling is indispensable for normal motor performance.

CACNA1A CACNA1B CACNA1E

6.81e-074194337141091
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

USP34 GADD45B PLXND1 KDM6B BIRC6 FASN DST MDN1 RPTOR MFN2 KIFC3 GNAZ DNMBP SMG6 FNTB SZT2 BTAF1 CDC42BPB SLC1A5 THADA MEGF8

1.12e-0611051942135748872
Pubmed

Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.

CACNA1A CACNA1B CACNA1E

1.69e-06519438825650
Pubmed

Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.

CACNA1A CACNA1B CACNA1E

1.69e-065194311296258
Pubmed

Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.

CACNA1A CACNA1B CACNA1E

1.69e-065194315451373
Pubmed

Indoleamine 2,3-dioxygenase is regulated by IFN-gamma in the mouse placenta during Listeria monocytogenes infection.

IDO1 CSF1 CSF1R

1.69e-065194312517946
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

USP34 TDRD15 EPS15 VPS13C LRRK2 PLXND1 BIRC6 DST FERMT1 RNF213 COPG2 LBR CDC42BPB SLC1A5 PCF11 THADA PRPS1

1.95e-067771941735844135
Pubmed

Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.

CACNA1A CACNA1B CACNA1E

3.38e-066194312827191
Pubmed

Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.

CACNA1A CACNA1B CACNA1E

3.38e-06619439238069
Pubmed

The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein.

GNAI2 GNAS GNAZ

3.38e-06619439647645
Pubmed

An action potential initiation mechanism in distal axons for the control of dopamine release.

CACNA1A CACNA1B CACNA1E

3.38e-066194335324301
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

ACADSB PDSS1 VPS13C DBT BIRC6 DST MDN1 ATXN2 RPTOR SYNE2 MFN2 GNAS SMG6 FXR2 RNF213 FNDC3A UFL1 LBR THADA ARID2 LRP2 AKAP11 VPS13B USP33

3.54e-0614961942432877691
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

USP34 NCKAP1 EIF3E BIRC6 FASN NF1 DST MDN1 SYNE2 FXR2 COPG2 OASL MTREX CNOT1 STAG2

4.48e-066531941522586326
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

VPS13C DST RPTOR SYNE2 VPS8 FNDC3A LBR MEGF8 LRP2 AKAP11 ATP4A VPS13B USP33

5.80e-065041941334432599
Pubmed

Rebuilding essential active zone functions within a synapse.

CACNA1A CACNA1B CACNA1E

5.88e-067194335176221
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

NCKAP1 KIAA0232 NF1 DST MDN1 RPTOR SYNE2 GNAS DNMBP CBX4 LBR ECT2 SLC1A5 MEGF8 AKAP11 PAN3 MTREX

7.57e-068611941736931259
Pubmed

Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human.

GNAI2 GNAS GNAT1 GNAZ

9.14e-062419442902634
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

USP34 TMEM183A ATRX CYP17A1 DZIP1L PHKB KCNJ1 PARP12 SPOPL MAP4K3 COPG2 TMEM183BP LRP2 ZMYM1 PAN3 HERC4 CNOT1 STAG2 VPS13B

1.17e-0510841941911544199
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

PRMT8 TMEM183A EIF3E ATXN2 MFN2 SPOP PARP12 FXR2 TMEM183BP ECT2 PAN3 CNOT1

1.25e-054621941231138677
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

EIF3E BIRC6 SYNE2 DNMBP CCDC93 CNOT11 VPS8 AKAP11 CNOT1

1.28e-05251194929778605
Pubmed

Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.

EIF3E BIRC6 PHKB GNAS FNDC3A COPG2 ATP4A

1.38e-05139194725476789
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1A CACNA1B CACNA1E

1.40e-059194316382099
Pubmed

5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.

SMG1 NF1 RPTOR COPG2

1.49e-0527194423027611
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

ATRX NCKAP1 VPS13C EIF3E DBT FASN NF1 MDN1 RPTOR GNAS TMEM117 MCOLN2 THOC1 UFL1 LBR SLC1A5 THADA UHRF1 MTREX CNOT1 STAG2 PRPS1

1.68e-0514251942230948266
Pubmed

G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development.

GNAI2 GNAS GNAT1 GNAZ

1.73e-052819448858601
Pubmed

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.

GNAI2 GNAT1 GNAZ

1.99e-051019438521505
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

SMG1 NF1 DST DNMBP THOC1 DNAH3 FXR2 LONP2 FERMT1 RFX3 UHRF1

2.14e-054101941126949251
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

USP34 FCHSD2 DST SMG6 VPS8 UFL1

2.28e-0510119469872452
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

LRRK2 RPTOR PKHD1 CACNA1B SZT2 RNF213 LRP2 CNOT1

2.38e-05208194833230847
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

ATRX FASN NF1 MDN1 GNAS FERMT1 COPG2 BTAF1 ECT2 PCF11 MTREX CNOT1 STAG2

2.64e-055821941320467437
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

EPS15 EIF3E FANCC PHKB RTKN2 FASN GNAI2 ABCG2 KIFC3 GNAS GNAT1 CNOT11 ECT2 PCF11 ARID2 ZMYM1 CNOT1 STAG2 VPS13B

2.80e-0511551941920360068
Pubmed

Mycobacterium leprae induces a tolerogenic profile in monocyte-derived dendritic cells via TLR2 induction of IDO.

IDO1 TLR2

3.10e-052194233040382
Pubmed

Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice.

CSF1 CSF1R

3.10e-052194232756440
Pubmed

A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations.

CSF1 CSF1R

3.10e-052194216877523
Pubmed

CSF-1R Inhibitor Development: Current Clinical Status.

CSF1 CSF1R

3.10e-052194228875266
Pubmed

CSF1/CSF1R-mediated Crosstalk Between Choroidal Vascular Endothelial Cells and Macrophages Promotes Choroidal Neovascularization.

CSF1 CSF1R

3.10e-052194233764399
Pubmed

Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers.

CACNA1A CACNA1B

3.10e-052194223376566
Pubmed

Engineering a monomeric variant of macrophage colony-stimulating factor (M-CSF) that antagonizes the c-FMS receptor.

CSF1 CSF1R

3.10e-052194228655719
Pubmed

Expression of colony-stimulating factor 1 is associated with occurrence of osteochondral change in pigmented villonodular synovitis.

CSF1 CSF1R

3.10e-052194225854167
Pubmed

Specific inhibition of PI3K p110δ inhibits CSF-1-induced macrophage spreading and invasive capacity.

CSF1 CSF1R

3.10e-052194223648053
Pubmed

Identification of the ligand-binding regions in the macrophage colony-stimulating factor receptor extracellular domain.

CSF1 CSF1R

3.10e-05219428355686
Pubmed

G-protein mutations in human pituitary adrenocorticotrophic hormone-secreting adenomas.

GNAI2 GNAS

3.10e-05219427737262
Pubmed

Relative atrophy of the flocculus and ocular motor dysfunction in SCA2 and SCA6.

ATXN2 CACNA1A

3.10e-052194215826995
Pubmed

Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculosis.

TLR2 CD180

3.10e-052194236370035
Pubmed

Temporal expression and location of colony-stimulating factor 1 (CSF-1) and its receptor in the female reproductive tract are consistent with CSF-1-regulated placental development.

CSF1 CSF1R

3.10e-05219422554332
Pubmed

Transfection of Vitamin D3-Induced Tolerogenic Dendritic Cells for the Silencing of Potential Tolerogenic Genes. Identification of CSF1R-CSF1 Signaling as a Glycolytic Regulator.

CSF1 CSF1R

3.10e-052194234298983
Pubmed

Effect of ABCC2 and ABCG2 Gene Polymorphisms and CSF-to-Serum Albumin Ratio on Ceftriaxone Plasma and Cerebrospinal Fluid Concentrations.

ABCG2 ABCC2

3.10e-052194229873816
Pubmed

Expression of macrophage colony-stimulating factor and its receptor in hepatic granulomas of Kupffer-cell-depleted mice.

CSF1 CSF1R

3.10e-05219429176397
Pubmed

c-Fms signaling mediates neurofibromatosis Type-1 osteoclast gain-in-functions.

NF1 CSF1R

3.10e-052194223144792
Pubmed

A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.

SPOP SPOPL

3.10e-052194216740475
Pubmed

Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup.

TMEM183A TMEM183BP

3.10e-052194216644869
Pubmed

Evolutionary expansion of SPOP and associated TD/POZ gene family: impact of evolutionary route on gene expression pattern.

SPOP SPOPL

3.10e-052194220399258
Pubmed

Metabolism, Transport and Drug-Drug Interactions of Silymarin.

ABCG2 ABCC2

3.10e-052194231615114
Pubmed

N-type calcium current, Cav2.2, is enhanced in small-diameter sensory neurons isolated from Nf1+/- mice.

NF1 CACNA1B

3.10e-052194224755485
Pubmed

Chromosomal assignment of the murine Gi alpha and Gs alpha genes. Implications for the obese mouse.

GNAI2 GNAS

3.10e-05219423117797
Pubmed

Mutagenesis as an unbiased approach to identify novel contraceptive targets.

DNAH1 SMC1B

3.10e-052194216412559
Pubmed

Primary structure of the alpha-subunit of transducin and its relationship to ras proteins.

GNAT1 GNAZ

3.10e-05219423923359
Pubmed

Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1.

CSF1 CSF1R

3.10e-052194222902366
Pubmed

Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice.

CSF1 CSF1R

3.10e-052194216823860
Pubmed

Vitamin D(3) and analogues modulate the expression of CSF-1 and its receptor in human dendritic cells.

CSF1 CSF1R

3.10e-052194212372416
Pubmed

High ABCC2 and low ABCG2 gene expression are early events in the colorectal adenoma-carcinoma sequence.

ABCG2 ABCC2

3.10e-052194225793771
Pubmed

A systematic review and meta-analysis of the association of ABCC2/ABCG2 polymorphisms with antiepileptic drug responses in epileptic patients.

ABCG2 ABCC2

3.10e-052194234087576
Pubmed

Inhibiting neutral amino acid transport for the treatment of phenylketonuria.

SLC6A19 PAH

3.10e-052194230046012
Pubmed

Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases.

CSF1 CSF1R

3.10e-052194219017797
Pubmed

Colony-stimulating factor-1 and colony-stimulating factor-1 receptor co-expression is associated with disease progression in gastric cancer.

CSF1 CSF1R

3.10e-052194229767252
Pubmed

Obesity-Associated GNAS Mutations and the Melanocortin Pathway.

MC4R GNAS

3.10e-052194234614324
Pubmed

CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response.

CSF1 CSF1R

3.10e-052194223451116
Pubmed

Blockade of macrophage colony-stimulating factor reduces macrophage proliferation and accumulation in renal allograft rejection.

CSF1 CSF1R

3.10e-052194212614284
Pubmed

Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles.

CSF1 CSF1R

3.10e-052194222153499
Pubmed

The prognostic impact of M-CSF, CSF-1 receptor, CD68 and CD3 in prostatic carcinoma.

CSF1 CSF1R

3.10e-052194218510570
Pubmed

Deficiency of SIAH1 promotes the formation of filopodia by increasing the accumulation of FASN in liver cancer.

FASN SIAH1

3.10e-052194239075049
Pubmed

The molecular signature of spermatogonial stem/progenitor cells in the 6-day-old mouse testis.

CSF1 CSF1R

3.10e-052194219109221
Pubmed

Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling.

CSF1 CSF1R

3.10e-052194222186992
Pubmed

Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1.

CSF1 CSF1R

3.10e-052194217438263
Pubmed

Blocking the R-type (Cav2.3) Ca2+ channel enhanced morphine analgesia and reduced morphine tolerance.

CACNA1B CACNA1E

3.10e-052194215610184
Pubmed

Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.

CACNA1A CACNA1B

3.10e-052194223426690
Pubmed

Autocrine CSF-1 and CSF-1 receptor coexpression promotes renal cell carcinoma growth.

CSF1 CSF1R

3.10e-052194222052465
Pubmed

Role of colony-stimulating factor-1 in bone metabolism.

CSF1 CSF1R

3.10e-05219427962166
Pubmed

Increased expression of macrophage colony-stimulating factor and its receptor in patients with endometriosis.

CSF1 CSF1R

3.10e-052194222365076
Pubmed

Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting.

ABCG2 ABCC2

3.10e-052194219541926
Pubmed

Macrophage accumulation at a site of renal inflammation is dependent on the M-CSF/c-fms pathway.

CSF1 CSF1R

3.10e-052194212223521
Pubmed

CaV 2.1 α1  subunit motifs that control presynaptic CaV 2.1 subtype abundance are distinct from CaV 2.1 preference.

CACNA1A CACNA1B

3.10e-052194238155373
Pubmed

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice.

CSF1 CSF1R

3.10e-052194224652541
Pubmed

Stimulation by n6-cyclopentyladenosine of A1 adenosine receptors, coupled to galphai2 protein subunit, has a capacitative effect on human spermatozoa.

ADORA1 GNAI2

3.10e-052194211369591
Pubmed

The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion.

CSF1 CSF1R

3.10e-052194216034075
Pubmed

Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.

CSF1 CSF1R

3.10e-052194222826234
Pubmed

LRRK2 aggravates kidney injury through promoting MFN2 degradation and abnormal mitochondrial integrity.

LRRK2 MFN2

3.10e-052194237633049
Pubmed

Colony stimulating factor 1 (CSF-1) and its in vivo role as delineated using osteopetrotic op/op mice.

CSF1 CSF1R

3.10e-05219421840281
Pubmed

The role of CSF-1 in normal and neoplastic breast physiology.

CSF1 CSF1R

3.10e-05219429893162
Pubmed

Biology and action of colony--stimulating factor-1.

CSF1 CSF1R

3.10e-05219428981357
Pubmed

CSF-1 and TPA stimulate independent pathways leading to lysosomal degradation or regulated intramembrane proteolysis of the CSF-1 receptor.

CSF1 CSF1R

3.10e-052194217967422
Pubmed

c-Fms tyrosine 559 is a major mediator of M-CSF-induced proliferation of primary macrophages.

CSF1 CSF1R

3.10e-052194217420255
InteractionC3orf18 interactions

SMG1 NF1 MDN1 MFN2 VPS8 UFL1 BTAF1 THADA STAG2 IPO11

9.74e-0811518310int:C3orf18
InteractionGYPA interactions

SMG1 TMEM183A PDSS1 NF1 MFN2 VPS8 FNDC3A UFL1 COG8 THADA STAG2

5.71e-0717418311int:GYPA
InteractionSIGLECL1 interactions

NF1 VPS8 RNF213 BTAF1 COG8 THADA STAG2 IPO11

9.01e-061131838int:SIGLECL1
InteractionMAD2L1BP interactions

ZNF202 FASN DNMBP DHX40 SPPL3 LBR

1.89e-05611836int:MAD2L1BP
InteractionGNAL interactions

SYNE2 GNAS SPOPL SPPL3 ECT2

2.01e-05371835int:GNAL
InteractionADORA1 interactions

ADORA1 GNAI2 GNAS GNAZ

3.49e-05211834int:ADORA1
InteractionMLNR interactions

VPS8 UFL1 BTAF1 THADA STAG2 IPO11

3.54e-05681836int:MLNR
InteractionGMPR interactions

FASN ATXN2 PRPS1

3.99e-0581833int:GMPR
InteractionGNG2 interactions

RPTOR GNAI2 GNAS GNAZ DNAAF2 ATP4A

5.31e-05731836int:GNG2
InteractionGPR17 interactions

MDN1 VPS8 SPPL3 RNF213 UFL1 BTAF1 COG8 THADA STAG2 USP33 IPO11

5.81e-0528318311int:GPR17
InteractionGCGR interactions

GNAS VPS8 RNF213 BTAF1 COG8 USP33 IPO11

6.57e-051101837int:GCGR
InteractionUSH1G interactions

GEM NF1 KIFC3 MICAL1

7.17e-05251834int:USH1G
CoexpressionGSE21670_UNTREATED_VS_TGFB_IL6_TREATED_CD4_TCELL_UP

USP34 BACH2 ZNF385B RTKN2 SYNE2 CCDC93 ATP13A5 ECT2 UHRF1 ZMYM1

1.80e-0619419210M7467
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

USP34 EPS15 ATRX NCKAP1 FCHSD2 DST MDN1 ATXN2 SYNE2 SPOP DNMBP CCDC93 FNDC3A BTAF1 PCF11 AKAP11 MTREX HERC4 STAG2 VPS13B

5.30e-0685619220M4500
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

SMG1 NBEAL1 VPS13C BIRC6 FANCC FCHSD2 FASN NF1 FNDC3A

7.65e-061801929M8239
CoexpressionGSE36826_NORMAL_VS_STAPH_AUREUS_INF_IL1R_KO_SKIN_DN

USP34 KIAA0232 DNMBP MAP4K3 GSAP LBR RNASE6 CSF1R ZMYM1

1.71e-051991929M9532
CoexpressionGSE40225_WT_VS_RIP_B7X_DIABETIC_MOUSE_PANCREATIC_CD8_TCELL_UP

SMG1 VPS13C BACH2 FCHSD2 PARP12 SLC6A16 GSAP EPG5 THADA

1.71e-051991929M9238
CoexpressionGSE40274_FOXP3_VS_FOXP3_AND_GATA1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN

FCHSD2 ATXN2 CACNA1A FNTB FXR2 MAP4K3 RNF213 SIAH1 OASL

1.71e-051991929M9180
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

USP34 SMG1 VPS13C BIRC6 NF1 SYNE2 SMG6 RNF213 BTAF1 EPG5 ARID2

7.15e-1018819411ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

USP34 BIRC6 FCHSD2 NF1 UTY TMEM117 MAP4K3 PAN3 HERC4 VPS13B

1.85e-081991941094b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellCOVID-19-kidney-Stressed_PCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC6A19 SSTR2 PKHD1 ABCC2 CACNA1E SLC47A2 RHEX PAH LRP2

1.06e-0718119496980ea624151da32b7f537f263e40fcb87a02e81
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TFCP2L1 SYNE2 PKHD1 KIAA1958 KIFC3 SLC47A2 AGBL4 RHEX LRP2

1.91e-0719419497002937e8903e037332a215d00fbc7c7843b33f2
ToppCellCOVID-19-kidney-TAL|kidney / Disease (COVID-19 only), tissue and cell type

LRRK2 CA10 TFCP2L1 DST KCNJ1 PKHD1 GP2 COL28A1 TLR2

2.09e-07196194904f5eb206ed3016a737609a3ebac0c1fcabb94ef
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

USP34 SMG1 ATRX SYNE2 UTY SMG6 RNF213 BTAF1 VPS13B

2.37e-071991949f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

USP34 SMG1 ATRX VPS13C BIRC6 SYNE2 RNF213 BTAF1 OASL

2.48e-07200194912f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellCOVID-19-kidney-PCT-S1/S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC6A19 PKHD1 ABCC2 CACNA1E SLC47A2 RHEX PAH LRP2

1.18e-06178194823a12d3d971b857d5be8e907334d1f6b49eeeb32
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ENPP2 GEM RTKN2 UPK1B THOC1 MAP4K3 MINPP1 ATP10D

1.57e-061851948e06a784a297f357f3f8e761c24fa70722048ab42
ToppCellCOVID-19-kidney-Mito-rich_PCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

SYNE2 PKHD1 ABCC2 CACNA1E SLC47A2 RHEX PAH LRP2

1.57e-0618519481bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IDO1 LRRK2 PKHD1 PARP12 RNF213 CMTM1 TLR2 OASL

1.57e-061851948f30fb9d75cdb757b206312992aaf7485bc900f96
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A19 PKHD1 KIFC3 ABCC2 CACNA1E SLC47A2 PAH LRP2

1.64e-0618619485784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

USP34 SMG1 ATRX NBEAL1 BIRC6 SPOPL ARID2 VPS13B

1.64e-06186194803db813598b67b1e08f759758a1c2023396921fa
ToppCellCOVID-19-kidney|COVID-19 / Disease (COVID-19 only), tissue and cell type

CA10 TFCP2L1 SYNE2 PKHD1 ABCC2 AGBL4 RHEX LRP2

1.71e-061871948d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF385B SYNE2 PKHD1 SLC47A2 AGBL4 RHEX PAH LRP2

1.85e-06189194828b502611829e4a24caff2562545c7db97686099
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRRK2 ZNF385B PKHD1 KIFC3 SLC47A2 AGBL4 RHEX LRP2

1.85e-0618919483b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP34 ATRX NBEAL1 VPS13C SYNE2 FNDC3A AKAP11 STAG2

2.00e-06191194860c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE2 PKHD1 KIFC3 ABCC2 SLC47A2 RHEX PAH LRP2

2.00e-0619119481c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP34 ATRX NBEAL1 VPS13C SYNE2 FNDC3A AKAP11 STAG2

2.00e-06191194809db184cb90fe282a14474d7217068c58092c6f8
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE2 PKHD1 KIFC3 ABCC2 SLC47A2 RHEX PAH LRP2

2.00e-0619119483c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

VPS13C BIRC6 UTY MCOLN2 RNF213 LBR SLC1A5 ARID2

2.00e-0619119489454f642c3621370fa23640b631301346b300950
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRRK2 ZNF385B PKHD1 KIFC3 SLC47A2 AGBL4 RHEX LRP2

2.00e-0619119481cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCell10x3'2.3-week_17-19-Myeloid_DC-DC-pDC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ENPP2 FCHSD2 GPR171 KIF17 MCOLN2 ZFAT RHEX RNASE6

2.00e-061911948faf4de97003a938a243b0101456913c2b0e1804f
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP34 ATRX NBEAL1 VPS13C SYNE2 FNDC3A AKAP11 STAG2

2.00e-061911948973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SMG1 RTKN2 SYNE2 MCOLN2 RNF213 BTAF1 RFX3 VPS13B

2.16e-0619319489337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellcontrol-cDC|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

IDO1 GEM DST KIF17 SLC1A5 RNASE6 CSF1R CD180

2.71e-06199194831825ba336603fe940dea6022e18ec25af110f4c
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

ATRX IDO1 VPS13C TFCP2L1 DST SYNE2 TLR2 STAG2

2.71e-061991948c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellCOVID-19-COVID-19_Mild|COVID-19 / Disease, condition lineage and cell class

SMG1 VPS13C KDM6B GNAI2 GNAS CSF1R OASL PAN3

2.81e-06200194862c25042086f1afd1102e0720e933c2e476468fd
ToppCellPND28-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MROH5 ACOX2 PKHD1 PNMA3 TMEM117 GP2 CATSPERB

3.47e-0614519479b69bfdbf91ef197b4c483617aa67498d9d2cd79
ToppCellPND28-Epithelial-Epithelial_Airway-Neurosecretory-Secretory|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MROH5 ACOX2 PKHD1 PNMA3 TMEM117 GP2 CATSPERB

3.47e-06145194731af9fce1dcd7e8ae1604476598e099232017ee9
ToppCellPND28-Epithelial-Epithelial_Airway-Neurosecretory|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MROH5 ACOX2 PKHD1 PNMA3 TMEM117 GP2 CATSPERB

3.47e-06145194776f0cde9acdc3ad5948c007dccf312665972c9e6
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

SMG1 SYNE2 UTY MCOLN2 SMG6 RNF213 BTAF1

5.63e-0615619471545169694f686d28648a68b552c2ae606599d66
ToppCell356C-Myeloid-Dendritic-pDC|356C / Donor, Lineage, Cell class and subclass (all cells)

SMG1 ENPP2 KIF17 ZFAT RHEX THADA RNASE6

5.63e-061561947d9d87368e43b24952e70f31f38425e15b716ff5b
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RSPH14 DZIP1L MROH9 DNAH3 RFX3 DNAH1 AGBL4

9.51e-061691947fba841664939c771881ba97f14ef1df6635c04ff
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GADD45B PIK3C2G PKHD1 ATP13A5 DNAH1 LRP2 UNC13C

9.51e-06169194712bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic-CD1c-positive_myeloid_dendritic_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

IDO1 GEM CC2D2B DNMBP MCOLN2 LONP2 TLR2

9.88e-061701947cc66ac6846c58be9493eb270644ee3ce0f86cfea
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 DZIP1L PLXND1 POU3F1 CSF1 CD180

1.02e-051131946ec4b89e727e1b921b9cb17443774955b95814dd4
ToppCell3'-Broncho-tracheal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GADD45B MBOAT1 ADORA1 THOC1 RHEX CSF1 SYNGR3

1.03e-0517119475885e69e997cc2f6a27afebfe57001ca0ac062a6
ToppCellCOVID_vent-Lymphocytic-Dendritic|COVID_vent / Disease condition, Lineage, Cell class and subclass

ENPP2 FCHSD2 MCOLN2 ZFAT PLEKHG4B RHEX RNASE6

1.03e-051711947debbb071d260639b16269c94d172766908325c58
ToppCellCOVID_vent-Lymphocytic-Dendritic-pDC|COVID_vent / Disease condition, Lineage, Cell class and subclass

ENPP2 FCHSD2 MCOLN2 ZFAT PLEKHG4B RHEX RNASE6

1.03e-051711947779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A19 ABCC2 CACNA1E ZFAT SLC47A2 PAH LRP2

1.11e-0517319478888434641ea554a9b62c436e87920378eef29cd
ToppCellCV-Severe-7|CV / Virus stimulation, Condition and Cluster

SMG1 DST UTY RNF213 SLC1A5 ARID2 ZMYM1

1.24e-0517619473de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCellnormal_Lung-Myeloid_cells-CD163+CD14+_DCs|normal_Lung / Location, Cell class and cell subclass

GADD45B KDM6B GNAI2 RNASE6 CSF1R TLR2 SMC1B

1.33e-051781947b6dacaad09bf4384d0d4c926fbf769e74a8ec9a9
ToppCellCOVID-19-kidney-PCT-S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

SYNE2 PKHD1 ABCC2 SLC47A2 RHEX PAH LRP2

1.43e-051801947358923e4228035a3e90e2957392089219e90dcd7
ToppCellCOVID-19-kidney-tDL|COVID-19 / Disease (COVID-19 only), tissue and cell type

PKHD1 ABCC2 CACNA1E SLC47A2 RHEX PAH LRP2

1.43e-051801947864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCell10x5'-bone_marrow-Myeloid_Mac-Macrophage|bone_marrow / Manually curated celltypes from each tissue

MBOAT1 DZIP1L GEM TFCP2L1 DST ABCG2 FNTB

1.48e-051811947d2aa5b53162fb5c4cbbedbd2cb4b2b614e8c4afa
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

USP34 SMG1 SYNE2 UTY RNF213 ARID2 HERC4

1.48e-051811947f2315414e714ac86211546a935660c4be6e85f1b
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_collecting_duct_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACADSB KIAA0232 PKDREJ S100A1 KCNJ1 PCDH8 ATP4A

1.54e-051821947ccfee33de0faebbe69099d4ff3c3971f6a708b99
ToppCelldroplet-Kidney-nan-24m-Lymphocytic-CD45____plasma_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNMB4 MCOLN2 CACNA1E MEF2B CBX4 RNASE6 SLC35B1

1.59e-051831947edb0069c66b1465dcc0bb5881417c6b17184fd74
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF385B RTKN2 SYNE2 PKHD1 KIFC3 GSAP PLEKHG4B

1.65e-05184194742ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCellPBMC-Severe-Myeloid-pDC-pDC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ENPP2 FCHSD2 KIF17 MCOLN2 ZFAT RHEX RNASE6

1.77e-05186194731df1eafa3010bc1be6fc4d4689f1393d69b6b13
ToppCellPBMC-Severe-Myeloid-pDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ENPP2 FCHSD2 KIF17 MCOLN2 ZFAT RHEX RNASE6

1.77e-051861947b95be984e308d4f9061274a35995ec558d434e74
ToppCellPBMC-Severe-Myeloid-pDC-pDC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ENPP2 FCHSD2 KIF17 MCOLN2 ZFAT RHEX RNASE6

1.77e-0518619478f7949740286f64e034d1eb533ebc2c6f71ae966
ToppCellPBMC-Severe-Myeloid-pDC-pDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ENPP2 FCHSD2 KIF17 MCOLN2 ZFAT RHEX RNASE6

1.77e-051861947b70cd94c651b56dcf2e55554533a5f1130845390
ToppCellfacs-Lung-EPCAM-3m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF385B FASN TFCP2L1 UPK1B GPR171 SLC1A5 LRP2

1.77e-0518619477c4eb769574f9f32753cea1cc38c711dabba88b9
ToppCellCOVID-19_Severe-Myeloid-pDC|COVID-19_Severe / Disease group, lineage and cell class

ENPP2 FCHSD2 KIF17 MCOLN2 ZFAT RHEX RNASE6

1.77e-0518619473db5ed69d49e5d79f990aca0295ddce4c297a05c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE2 PKHD1 KIFC3 SLC47A2 AGBL4 RHEX LRP2

1.77e-051861947b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCellPBMC-Severe-Myeloid-pDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ENPP2 FCHSD2 KIF17 MCOLN2 ZFAT RHEX RNASE6

1.77e-051861947eaa431ccd4cdd36fe06a44987603ec9979025aa8
ToppCellPBMC-Severe-Myeloid-pDC-pDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ENPP2 FCHSD2 KIF17 MCOLN2 ZFAT RHEX RNASE6

1.77e-05186194795c7318e521fb6aa02e244b1e81e6b2a62107756
ToppCellEpithelial-C_(AT2)|World / shred on cell class and cell subclass (v4)

SWT1 LRRK2 ZNF385B FASN TFCP2L1 GSAP LRP2

1.77e-051861947b7b1763fc52b4485d843a4a6727055e6c95ebad3
ToppCellfacs-Kidney-nan-3m-Epithelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACADSB ENPP2 S100A1 TFCP2L1 DST KCNJ1 PAH

1.83e-051871947208686e6ebc9f3a774bcbe89274457ac9449f90e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRRK2 PKHD1 KIFC3 SLC47A2 RHEX PAH LRP2

1.83e-0518719479d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF385B RTKN2 SYNE2 PKHD1 KIFC3 GSAP PLEKHG4B

1.83e-05187194758d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCellnormal_Lung-Myeloid_cells-pDCs|normal_Lung / Location, Cell class and cell subclass

FCHSD2 KIFC3 KIF17 MICAL1 UFL1 RHEX RNASE6

1.83e-051871947d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE2 PKHD1 ABCC2 SLC47A2 RHEX PAH LRP2

1.83e-051871947dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE2 PKHD1 ABCC2 SLC47A2 RHEX PAH LRP2

1.83e-051871947f1356273bd3587b6883295edf15cb9cdb706c057
ToppCell10x5'v1-week_14-16-Myeloid_DC-DC-pDC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FCHSD2 KIF17 MCOLN2 MEF2B ZFAT RHEX RNASE6

1.83e-051871947bf64a6ef5062ec9a0f7095e8c97ce66bfc3bf179
ToppCellCOVID-19-kidney-Mito-rich_PCT|kidney / Disease (COVID-19 only), tissue and cell type

SYNE2 PKHD1 ABCC2 SLC47A2 RHEX PAH LRP2

1.83e-051871947738ec2611b4be6a08eedad16b57fba84e1f11fef
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

USP34 GNAZ CACNA1B CACNA1E USP29 SYNGR3 PCDH8

1.89e-051881947b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCelltumor_Lung-Myeloid_cells-CD141+_DCs|Myeloid_cells / Location, Cell class and cell subclass

RSPH14 IDO1 UPK1B GPR171 GNAZ MCOLN2 RHEX

1.89e-0518819479874ba56bf6a0d509cccc89563dbf1395e17e84e
ToppCellCOVID-19-kidney-PCT-S2|kidney / Disease (COVID-19 only), tissue and cell type

SYNE2 PKHD1 ABCC2 SLC47A2 RHEX PAH LRP2

1.96e-0518919470be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCellPCW_05-06-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

PRMT8 ZNF385B PIK3C2G PKHD1 GSAP ECT2 LRP2

1.96e-051891947c8b8f860aaf6c73863cd79941db6b469c830ef06
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF385B PKHD1 KIFC3 SLC47A2 AGBL4 RHEX LRP2

2.03e-051901947989d4eefd22d66ecb857836f8fdbcf41e3047f84
ToppCell10x5'v1-week_14-16-Myeloid_DC-DC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FCHSD2 KIF17 MCOLN2 ZFAT RHEX RNASE6 CD180

2.03e-051901947d06800ec9f6065c1cc536ed99e8569732272a94f
ToppCell10x5'v1-week_14-16-Myeloid_DC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FCHSD2 KIF17 MCOLN2 ZFAT RHEX RNASE6 CD180

2.03e-051901947485073e831afebdb393c7f4b622504d43d1b778b
ToppCell(011)_pDC|World / immune cells in Peripheral Blood (logTPM normalization)

ENPP2 KIF17 MCOLN2 ZFAT SLC1A5 RHEX RNASE6

2.10e-051911947d82ac4f6d9863734e09bf3cb71c1354a49b66b4f
ToppCell(01)_Dendritic_cell|World / immune cells in Peripheral Blood (logTPM normalization)

GEM DST KIF17 ZFAT SLC1A5 RHEX RNASE6

2.10e-0519119471f4c8078e1a6cd14937c714330af608caced2acf
ToppCellCOVID-19-kidney-TAL|COVID-19 / Disease (COVID-19 only), tissue and cell type

CA10 TFCP2L1 KCNJ1 PKHD1 GP2 COL28A1 AGBL4

2.10e-051911947fe55475ce0666ab5122447a813dc2369e24947b8
ToppCellCOVID-19-kidney-Mito-rich_Distal|COVID-19 / Disease (COVID-19 only), tissue and cell type

CA10 TFCP2L1 KCNJ1 SYNE2 PKHD1 GP2 AGBL4

2.10e-0519119470965f621ebcd92ccdeb21cc27022180ce3cfe910
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

USP34 BIRC6 FCHSD2 MAP4K3 PAN3 VPS13B EPB42

2.24e-051931947779276e775cb2492e8dd36436295a536084a6415
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

EIF3E ATXN2 TMEM117 SPPL3 RFX3 ARID2 MTREX

2.24e-051931947e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell10x5'v1-week_17-19-Myeloid_DC-DC-pDC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ENPP2 FCHSD2 KIF17 MCOLN2 ZFAT RHEX RNASE6

2.24e-0519319472a48e72f3df2ad64e1680fca759be8fd2190771e
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

USP34 ATRX NBEAL1 BIRC6 SPOPL STAG2 VPS13B

2.24e-051931947abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMG1 VPS13C SLC6A19 PLXND1 UTY LBR PAN3

2.24e-051931947a6a864644e1b80b7417ea0a27281e79068a3fd3d
ToppCellmoderate-Myeloid-Monocyte-derived_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

IDO1 ENPP2 SSTR2 PARP12 CACNA1A RNF213 OASL

2.24e-05193194722455801194bd8c73c5c397f5eac4f723429c383
ToppCellmoderate-Myeloid-Monocyte-derived_Macrophage|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

IDO1 ENPP2 SSTR2 PARP12 CACNA1A LILRA3 OASL

2.40e-0519519479c9634906168239cf978adb398787692437bf9e7
ToppCelldroplet-Kidney-nan-3m-Epithelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACADSB ENPP2 S100A1 TFCP2L1 DST KCNJ1 PAH

2.48e-0519619479f39cb3de886283da34ee7511a92d94930a6c851
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRRK2 TFCP2L1 PKHD1 KIAA1958 KIFC3 AGBL4 RHEX

2.48e-0519619476ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell10x3'2.3-week_17-19|World / cell types per 3 fetal stages;per 3',per 5'

GADD45B SMG1 KDM6B GNAS UTY CBX4 PCF11

2.56e-051971947f5cfad0b42d0f817e22cc78b9bfb2b4b7e4330ed
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

USP34 SMG1 RTKN2 SYNE2 RNF213 BTAF1 RFX3

2.56e-05197194757ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

VPS13C MROH5 RTKN2 SYNE2 PKHD1 KIFC3 GSAP

2.56e-051971947b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRMT8 DZIP1L SYNE2 DNAH3 RFX3 PLEKHG4B AGBL4

2.56e-05197194774a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellTCGA-Skin-Metastatic-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

USP34 ATRX NBEAL1 VPS13C LBR CSF1R CD180

2.64e-051981947af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCellControl_saline-Epithelial_alveolar-AT_1-Differentiating_AT1|Control_saline / Treatment groups by lineage, cell group, cell type

NBEAL1 RTKN2 SYNE2 PKHD1 KIFC3 MICAL1 GSAP

2.64e-05198194785f424cd9bb3117c9e322031024aabb87696ce47
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)

SMG1 VPS13C KDM6B GNAS PARP12 RNF213 OASL

2.64e-05198194744417089b62056269cac38d3134ff209c05b7007
ToppCellAT2_cells-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

NCKAP1 LRRK2 ZNF385B PLXND1 GEM FASN LRP2

2.64e-051981947893036558a9ad86b57f9e735df35812e9d18739e
ToppCellTCGA-Skin-Metastatic|TCGA-Skin / Sample_Type by Project: Shred V9

USP34 ATRX NBEAL1 VPS13C LBR CSF1R CD180

2.64e-051981947ad39cce004867f083f8da1954e0cf5a263815184
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

USP34 ATRX NBEAL1 VPS13C LBR CSF1R CD180

2.64e-05198194762cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SMG1 VPS13C KDM6B GNAS PARP12 RNF213 OASL

2.64e-05198194728ef3fc4c17dcb765537b75917f7db78baa522db
ToppCellCOVID-19_Moderate|World / disease group, cell group and cell class

ATRX BACH2 SYNE2 GPR171 PARP12 RNF213 OASL

2.73e-051991947952fac67588ad5676f5939e3c7f8bac803c27064
DrugAC 110

CACNA1A CACNA1B CACNA1E

2.38e-0641933CID000022860
DrugTheophylline

EPS15 ATRX NBEAL1 EIF3E KDM6B ADORA1 FCHSD2 PKHD1 KCNMB4 GNAI2 GNAS CCDC93 FNTB EPG5 OSBP ARID2 PAN3

3.15e-0653219317ctd:D013806
Diseasefamilial hemiplegic migraine 1 (implicated_via_orthology)

CACNA1A CACNA1B CACNA1E

2.55e-0731883DOID:0111181 (implicated_via_orthology)
Diseasemigraine (implicated_via_orthology)

CACNA1A CACNA1B CACNA1E

1.01e-0641883DOID:6364 (implicated_via_orthology)
Diseasemyocardial infarction

TDRD15 NBEAL1 CYP17A1 MC4R CA10 ATXN2 GNAI2 ABCG2 DNMBP PARP12 SMG6 THADA

2.83e-0635018812EFO_0000612
DiseaseMalignant neoplasm of breast

CATSPERE IDO1 CYP17A1 PKDREJ PHKB FASN NF1 KCNJ1 UPK1B SYNE2 GNAI2 ABCG2 MICAL1 ECT2 EPG5 THBS3 CSF1 CSF1R PCDH8 VPS13B PRPS1

5.52e-06107418821C0006142
Diseasehereditary ataxia (implicated_via_orthology)

CACNA1A CACNA1B CACNA1E

8.74e-0671883DOID:0050951 (implicated_via_orthology)
DiseaseMcCune Albright syndrome (implicated_via_orthology)

GNAI2 GNAT1 GNAZ

1.39e-0581883DOID:1858 (implicated_via_orthology)
Diseasetotal blood protein measurement

BACH2 CC2D2B ATXN2 PKHD1 SMG6 DNAH3 MEF2B MAP4K3 SPPL3 DNAH1 CSF1 CSF1R

3.40e-0544918812EFO_0004536
DiseaseAutosomal recessive polycystic kidney disease

DZIP1L PKHD1

4.04e-0521882cv:C0085548
DiseaseX-24588 measurement

PDSS1 ABCC2 DNMBP

6.95e-05131883EFO_0800898
DiseaseMYELODYSPLASTIC SYNDROME

ATRX FANCC CSF1R TLR2 STAG2

6.98e-05671885C3463824
DiseaseProteinuria

SMG6 LRP2 UNC13C

1.09e-04151883HP_0000093
DiseaseCohen syndrome (implicated_via_orthology)

VPS13C VPS13B

1.21e-0431882DOID:0111590 (implicated_via_orthology)
Diseaseglycosyl ceramide (d16:1/24:1, d18:1/22:1) measurement

SYNE2 ATP10D

1.21e-0431882EFO_0800530
DiseaseLiposarcoma, Pleomorphic

FASN NF1

2.40e-0441882C0205825
Diseaselatent autoimmune diabetes in adults

BACH2 THADA

2.40e-0441882EFO_0009706
Diseasecystatin C measurement

SLC6A19 TFCP2L1 ATXN2 PKHD1 GNAI2 GNAS FNDC3A DNAH1 CSF1 LRP2

2.74e-0440218810EFO_0004617
Diseasemean arterial pressure

CYP17A1 ATXN2 RPTOR PKHD1 GNAS SMG6 MEF2B SZT2 RNF213 THBS3 THADA

3.82e-0449918811EFO_0006340
Diseasecarotid stenosis (implicated_via_orthology)

MFN2 TLR2

3.99e-0451882DOID:13001 (implicated_via_orthology)
Diseaseliposarcoma

FASN NF1

5.96e-0461882C0023827
DiseaseLiposarcoma, well differentiated

FASN NF1

5.96e-0461882C1370889
Disease3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-CMPFP) measurement

ABCC2 DNMBP

5.96e-0461882EFO_0800566
DiseaseX-21471 measurement

ABCC2 DNMBP

5.96e-0461882EFO_0800818
DiseaseLiposarcoma, Dedifferentiated

FASN NF1

5.96e-0461882C0205824
Diseaseglycocholenate sulfate measurement

ABCC2 DNMBP

5.96e-0461882EFO_0800276
Diseasegout (is_implicated_in)

ABCG2 PRPS1

5.96e-0461882DOID:13189 (is_implicated_in)
Diseaseepilepsy (implicated_via_orthology)

CACNA1A CACNA1B CACNA1E SLC1A5 UNC13C ATP4A

6.41e-041631886DOID:1826 (implicated_via_orthology)
Diseasecoronary artery disease, plasminogen activator inhibitor 1 measurement

TDRD15 NBEAL1 ATXN2 SMG6

7.09e-04631884EFO_0001645, EFO_0004792
DiseaseCholestasis

MBOAT1 GNAS ABCC2 TMEM117 TLR2

7.10e-041101885C0008370
DiseaseHematopoetic Myelodysplasia

ATRX TLR2 STAG2

8.23e-04291883C2713368
Diseasefamilial hemiplegic migraine (implicated_via_orthology)

CACNA1A ATP4A

8.30e-0471882DOID:0060178 (implicated_via_orthology)
Diseasequinolinate measurement

IDO1 ATXN2

8.30e-0471882EFO_0800175
Diseaseglycosyl ceramide (d18:1/20:0, d16:1/22:0) measurement

SYNE2 ATP10D

8.30e-0471882EFO_0800551
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

ACOX2 ATXN2 ABCC2 DNMBP CSF1 UHRF1 ELOVL3

8.92e-042391887EFO_0010934
Diseasecerebellar ataxia (implicated_via_orthology)

VPS13C CACNA1A

1.10e-0381882DOID:0050753 (implicated_via_orthology)
Diseaseholoprosencephaly (is_implicated_in)

CNOT1 STAG2

1.10e-0381882DOID:4621 (is_implicated_in)
DiseaseDisorder of amino acid metabolism

DBT PAH

1.10e-0381882cv:C0002514
Diseasetissue plasminogen activator measurement, coronary artery disease

TDRD15 NBEAL1 ATXN2 SMG6

1.11e-03711884EFO_0001645, EFO_0004791
Diseasehyperuricemia

ABCG2 GNAS LRP2

1.21e-03331883EFO_0009104
Diseaseplatelet crit

ATRX BACH2 LRRK2 KDM6B S100A1 PHKB NF1 ATXN2 MFN2 SMG6 DNAH3 FNTB EPG5 THADA CSF1

1.21e-0395218815EFO_0007985
Diseasepulse pressure measurement, migraine without aura, susceptibility to, 4

SPOP SLC35B1

1.41e-0391882EFO_0005763, MONDO_0011847
DiseaseAutosomal Recessive Polycystic Kidney Disease

DZIP1L PKHD1

1.41e-0391882C0085548
DiseaseX-21467 measurement

ABCC2 DNMBP

1.41e-0391882EFO_0020007
Diseasehip circumference

CYP17A1 MC4R PLXND1 RTKN2 FASN NF1 GP2 ZFAT

1.53e-033381888EFO_0005093
Diseasered blood cell density measurement

BACH2 KDM6B TFCP2L1 DST ATXN2 PKHD1 SMG6 ZFAT FNTB SIAH1 THBS3 ARID2 HERC4 VPS13B

1.60e-0388018814EFO_0007978
Diseasealcohol use disorder (implicated_via_orthology)

KDM6B UTY GPR21 MAP4K3 ARID2 UNC13C

1.62e-031951886DOID:1574 (implicated_via_orthology)
DiseaseGlobal developmental delay

CACNA1B CACNA1E SZT2 CNOT1 STAG2

1.66e-031331885C0557874
Diseasecoronary artery disease

TDRD15 RSPH14 NBEAL1 MC4R GEM ATXN2 RPTOR PKHD1 GNAI2 ABCG2 PARP12 SMG6 GP2 RNF213 EPG5 THADA UHRF1

1.72e-03119418817EFO_0001645
Diseaseurate measurement

USP34 MC4R BIRC6 TFCP2L1 ATXN2 PKHD1 ABCG2 GNAS DNAH3 DNAH1 THBS3 LRP2 UHRF1 HERC4

1.87e-0389518814EFO_0004531
DiseaseColorectal Carcinoma

ADORA1 NF1 PKHD1 ABCG2 GNAS ABCC2 CCDC93 DNAH3 OSBP TLR2 LRP2 PRPS1

1.91e-0370218812C0009402
DiseaseDrug toxicity

ADORA1 ABCG2 ABCC2 TLR2

2.07e-03841884C0013221
DiseaseAdverse reaction to drug

ADORA1 ABCG2 ABCC2 TLR2

2.07e-03841884C0041755
Diseasecerebral cavernous malformation (implicated_via_orthology)

RNF213 CDC42BPB

2.14e-03111882DOID:0060669 (implicated_via_orthology)
DiseaseNeuroendocrine Tumors

ATRX SSTR2

2.14e-03111882C0206754
Diseaselung adenocarcinoma (is_marker_for)

ATRX SPOP SLC1A5 CSF1R

2.16e-03851884DOID:3910 (is_marker_for)
DiseaseCrohn's disease

USP34 BACH2 LRRK2 FCHSD2 ATXN2 FERMT1 GSAP THADA AKAP11

2.18e-034411889EFO_0000384
Diseasephysical activity

MBOAT1 PLPPR5 PKHD1 PCF11

2.45e-03881884EFO_0003940
Diseaseautoimmune thyroiditis (is_implicated_in)

ZFAT LRP2

2.56e-03121882DOID:7188 (is_implicated_in)
Diseasecoffee consumption measurement, tea consumption measurement

MC4R ATXN2 ABCG2

2.78e-03441883EFO_0006781, EFO_0010091
Diseaselung disease (implicated_via_orthology)

ADORA1 TLR2

3.01e-03131882DOID:850 (implicated_via_orthology)
DiseaseGenetic chronic primary adrenal insufficiency

BACH2 ATXN2

3.01e-03131882Orphanet_101960
Diseaseserum metabolite measurement

TDRD15 PHKB SYNE2 ABCG2 ABCC2 MROH9 CACNA1E ASB17 SPPL3 SIAH1 ATP10D CSF1R PAH OASL

3.06e-0394518814EFO_0005653
Diseaseanti-basement membrane glomerulonephritis (implicated_via_orthology)

CSF1 CSF1R

3.49e-03141882DOID:4780 (implicated_via_orthology)
DiseaseX-21470 measurement

ABCC2 DNMBP

3.49e-03141882EFO_0800817
DiseaseBody Weight

MC4R GP2

4.01e-03151882C0005910
DiseaseNeoplasm of uncertain or unknown behavior of bladder

FANCC STAG2

4.01e-03151882C0496930
DiseaseBenign neoplasm of bladder

FANCC STAG2

4.01e-03151882C0154017
DiseaseCarcinoma in situ of bladder

FANCC STAG2

4.01e-03151882C0154091
Diseaseresponse to statin, LDL cholesterol change measurement

TDRD15 ABCG2

4.01e-03151882EFO_0007804, GO_0036273
DiseaseWeight Gain

IDO1 COPG2 IPO11 PRPS1

4.17e-031021884C0043094
Diseaselung small cell carcinoma (is_marker_for)

ATRX CSF1R

4.57e-03161882DOID:5409 (is_marker_for)
Diseasesphingomyelin 18:0 measurement

AGBL4 IPO11

4.57e-03161882EFO_0010393
Diseaseautosomal recessive polycystic kidney disease (implicated_via_orthology)

DZIP1L PKHD1

4.57e-03161882DOID:0110861 (implicated_via_orthology)
Diseaserenal fibrosis (implicated_via_orthology)

GPR21 TLR2

5.16e-03171882DOID:0050855 (implicated_via_orthology)
DiseaseMoyamoya Disease

NF1 RNF213

5.16e-03171882C0026654
DiseaseX-21441 measurement

ABCC2 DNMBP

5.16e-03171882EFO_0800814
Diseasesphingomyelin 14:0 measurement

SYNE2 THADA

5.16e-03171882EFO_0010390
Diseaseleukemia

FANCC NF1 STAG2

5.24e-03551883C0023418
Diseaseresponse to antidepressant

ACADSB MROH5 CA10 ABCG2 ZFAT

5.51e-031761885GO_0036276
Diseasecoronary artery disease, factor VII measurement

TDRD15 NBEAL1 ATXN2 SMG6

5.63e-031111884EFO_0001645, EFO_0004619
Diseasemigraine disorder, systolic blood pressure

SMG6 RNF213

5.78e-03181882EFO_0006335, MONDO_0005277
DiseaseCarcinoma of bladder

FANCC STAG2

5.78e-03181882C0699885
Diseaseuric acid measurement

USP34 SWT1 MC4R BIRC6 ABCG2 GNAS DNAH3 LRP2 HERC4 IPO11

5.97e-0361018810EFO_0004761
Diseaseendometrial carcinoma

FCHSD2 NF1 MDN1 ATXN2

5.99e-031131884EFO_1001512
Diseasecholesterol in IDL measurement

TDRD15 ATXN2 MOGAT2

6.07e-03581883EFO_0021899
Diseasehepatocellular carcinoma (is_implicated_in)

SPOP CBX4 CSF1R ARID2 TLR2

6.19e-031811885DOID:684 (is_implicated_in)
Diseasecoffee consumption measurement

EIF3E BIRC6 PKHD1 GNAI2 ABCG2

6.33e-031821885EFO_0006781
Diseasehemoglobin A1 measurement

MC4R PLXND1 SYNE2 ABCG2 SMG6 ZFAT GSAP THBS3 THADA

6.36e-035201889EFO_0007629
Diseasefactor XI measurement, coronary artery disease

TDRD15 NBEAL1 ATXN2 SMG6

6.37e-031151884EFO_0001645, EFO_0004694

Protein segments in the cluster

PeptideGeneStartEntry
FDNILFAVLTVFQCI

CACNA1A

301

O00555
LADFCNILTAVNQSE

SMG6

1061

Q86US8
AVSDLFAAINASCVV

EPB42

381

P16452
RQFFTSCIEILGQVF

EPG5

1691

Q9HCE0
ILLTDAFDFTDQCLN

ACOX2

621

Q99424
LEDSCFSFLQTQLLN

BACH2

121

Q9BYV9
ALFQCVAAVFIAQLS

SLC1A5

391

Q15758
ALTQFCVAFFVEDSI

ATP13A5

1121

Q4VNC0
RTAIENATVAFFLQC

BIRC6

3756

Q9NR09
ISGVTFCNLIEEFQI

CATSPERB

1031

Q9H7T0
VTFQDCFIADFLILL

CATSPERE

201

Q5SY80
QFDNILFAVLTVFQC

CACNA1E

291

Q15878
VNQALRDATFCFIVS

ADORA1

36

P30542
VVIEFDQNVFTAFTC

FERMT1

621

Q9BQL6
FQEVSDLRCLNISFL

A4GNT

241

Q9UNA3
NQCFSSVSAVELFVV

ABCG2

436

Q9UNQ0
NEVDFAINVCTLLSN

ARID2

171

Q68CP9
VFTAIVNNTFQTCVE

ACOT12

246

Q8WYK0
VDASVAVFCEIQNTL

ACADSB

131

P45954
QFDELEQTLETCLFN

AKAP11

361

Q9UKA4
FVCICEFTSQELDNL

DNMBP

71

Q6XZF7
EELSFTSAFCLQIQR

PRMT8

286

Q9NR22
STTFQCFTQLQELDL

CD180

291

Q99467
ECTFLNIFATIEPQI

CC2D2B

1051

Q6DHV5
NFDNILFAILTVFQC

CACNA1B

296

Q00975
QSIHDCVFFAVQVLE

CDAN1

361

Q8IWY9
DFFIALAICNTVVVS

ATP10D

586

Q9P241
FFIILCRNLSNVEEI

NBEAL1

96

Q6ZS30
QVTLFLFNDCLEIAR

ECT2

691

Q9H8V3
NSDCVLSFFLSEAVQ

PIK3C2G

1296

O75747
VVFDCKFIETSAAVQ

GEM

211

P55040
FLQFALAATVFCVVL

LBR

326

Q14739
DVATLQENIAGITFC

DZIP1L

51

Q8IYY4
NVQICSIFDIATELN

DBT

361

P11182
DTSINVLVDFVINSC

OR6N1

191

Q8NGY5
QSSVFQCFDVLLGIQ

IDO1

266

P14902
FDFQIESIVCLQDSV

MAP4K3

816

Q8IVH8
LSASLNIFQEALDCF

MDN1

566

Q9NU22
FVTASCLDEVLNAAF

LONP2

821

Q86WA8
ANCIFLNITNSELFI

FXR2

166

P51116
CATDTQNVKFVFDAV

GNAT1

321

P11488
SFGLVTCFQQESLDV

DNAAF2

721

Q9NVR5
AVTSCQEQLDAFQVL

DST

4366

Q03001
FEVSFNLDFTEICVN

ASB17

81

Q8WXJ9
ESILFKCSDFVVVQF

ATXN2

326

Q99700
FTLLFQLLQQVTECD

IPO11

561

Q9UI26
NECDVEVFNILFVTS

KDM6B

1576

O15054
ACTAVLENLFFSAVL

SLC43A1

16

O75387
AVFCLQLATRDFENQ

PLPPR5

86

Q32ZL2
IDACLSVIAQAFIDA

PLXND1

1791

Q9Y4D7
SCFSVFEVQCSNSVL

KIAA0232

646

Q92628
FLLANLSFIDVCVAS

OR4K15

61

Q8NH41
SCSDTFLSQVVNFLV

OR5A1

191

Q8NGJ0
QCVLAFDVVSFSQEQ

PCDH8

101

O95206
IEETFCLNFTITVEN

HERC4

856

Q5GLZ8
CLNFTITVENFGATE

HERC4

861

Q5GLZ8
DFIIRDTILNINFQC

GP2

306

P55259
NFICVAIFLNFSAII

GPR171

181

O14626
EQELFVQFCTVFLED

COG8

491

Q96MW5
VFVTSLEACVTQSFL

MEGF8

666

Q7Z7M0
NVFSQTTICRFEALQ

POU3F1

286

Q03052
AQVFDILNSAELVCL

LRRK2

2126

Q5S007
LQFNNIASITDDTFC

OGN

241

P20774
SFLQAQLCQDVLSSF

MICAL1

16

Q8TDZ2
LLAFSQLQCVVIFVF

ABCC2

536

Q92887
AAIISSFFLATVVQC

LRRC38

261

Q5VT99
NCAISTENFLIFALS

LRP2

2381

P98164
LAFLSQQSFDALCAV

CDC42BPB

1416

Q9Y5S2
VLIFLTEVSFVDCEQ

MROH9

526

Q5TGP6
LATANITVEDSCNFI

OSBP

136

P22059
CEIALIIFNSANRLF

MEF2B

41

Q02080
QLEDVSQFLQTCTGF

PAH

226

P00439
LNTIDVCQVFFDITV

NCKAP1

111

Q9Y2A7
VCQVFFDITVNFDLT

NCKAP1

116

Q9Y2A7
FCLDADVFVLVANSE

MFN2

216

O95140
DTQINQLLLFALCSF

OR5AS1

191

Q8N127
EVELVAFLSCFHSFQ

OASL

81

Q15646
TSAIFVDAICQQNFD

PARP12

566

Q9H0J9
QECVGFEISVFLQTL

GPRC6A

61

Q5T6X5
AFTKNLVATFICVFE

PCF11

91

O94913
LQFVFSFLALAEICT

MOGAT2

21

Q3SYC2
VNCVGVFDVLTFDNS

PAN3

656

Q58A45
IRTQILFFCVSDLAN

DNAH1

3451

Q9P2D7
SACHSFDLIQEFIIA

GSAP

456

A4D1B5
ITTCNFDVDVDLLFQ

CCDC93

61

Q567U6
LVTACNSVFENLEQL

ATRX

276

P46100
QIVCSASSVDVNFDV

CSF1R

221

P07333
CATDTSNIQFVFDAV

GNAZ

326

P19086
QGSICFIDIVFIVDS

COL28A1

41

Q2UY09
TSCQITFEFVDQEQL

CSF1

61

P09603
HIFQFCVLESSQEIL

BTAF1

566

O14981
SATIFFCISDLANIE

DNAH3

3301

Q8TD57
TVCFINFIDNSTVKF

ELOVL3

101

Q9HB03
IAFQLIDDVLDFTSC

PDSS1

301

Q5T2R2
TLIQSFCCDNDINIV

GADD45B

76

O75293
EQCAAVILVLFAFFS

FNDC3A

1171

Q9Y2H6
VFVAVTNVISLICFN

CYP17A1

171

P05093
IIATIQVFTQCFVEA

FANCC

311

Q00597
QVFTQCFVEALEKAS

FANCC

316

Q00597
FFGNIIITDVTANCL

CBX4

536

O00257
SSFVCQGIIDFLVSQ

AGBL4

236

Q5VU57
QCFNDVTAIIFVVAS

GNAS

236

P63092
IVFQFDCTNTLNDQL

COPG2

656

Q9UBF2
ESVLVNDFFLVACLE

EIF3E

316

P60228
LDQVNFVVCQLVALF

MBOAT1

31

Q6ZNC8
SFTVNIDNVIDSVIC

MC4R

116

P32245
IVATDVCQFLELCQS

FNTB

121

P49356
VLSVQQIGEVFECTF

KCNMB4

56

Q86W47
QEFFVALRLVACAQN

EPS15

71

P42566
ELETCQAVQNTFQFL

FCHSD2

256

O94868
VEESLTCQIFGFVVS

GPR21

96

Q99679
AEAETEAICFFVQQF

FASN

2361

P49327
EVLFLLQANFIVCIS

CA10

6

Q9NS85
NDFATLAVIFEQCKS

DHX40

551

Q8IX18
TVFFISIEVCQIADV

ATP4A

931

P20648
QIISLFTFAVGVNIC

ENPP2

11

Q13822
FENLNTVAECLFSLV

MCOLN2

446

Q8IZK6
TDEVSFIQNLVFCVE

PHKB

196

Q93100
VTIQCDSQVAFDGFI

LILRA3

141

Q8N6C8
LDLSFCESTFINNFI

OR5D13

166

Q8NGL4
ISQRLCFIIAIFNEV

OR5D13

196

Q8NGL4
ALACTNTQAVELVAF

OR6F1

186

Q8NGZ6
VFESVQCAENTKFLV

KIF17

121

Q9P2E2
LLACTNTDVNEFVIF

OR10R2

206

Q8NGX6
LDGFFQSSDQVIVCI

MROH5

1086

Q6ZUA9
TITDICFENVTIFNE

RTKN2

151

Q8IZC4
VCSSTFTDLEANQLF

GTF2E1

131

P29083
NQKFTDCFVLVFLDS

SZT2

3366

Q5T011
CEVEVFNLLFVTNES

UTY

1281

O14607
AQLVFQTCDINAFLS

SLC6A19

376

Q695T7
EFAFCQVDASIALAL

THADA

1766

Q6YHU6
NLLTLLVFTSFNFCV

SLC6A16

381

Q9GZN6
VVSLFLQACFLTAIN

RHEX

16

Q6ZWK4
VVLVAALTVACNNFF

S100A1

76

P23297
ELASVTLAVAFVNVC

SLC47A2

66

Q86VL8
DFVNQSLLQLSTCDV

SYNE2

5116

Q8WXH0
ISFECLFADLEINIL

TDRD15

1651

B5MCY1
CEAILDVVVNLQFSL

RFX3

361

P48380
DCCLLQVTTLNFIFI

TMEM183BP

291

Q1AE95
FQEVQALVTSCIDGF

KIFC3

506

Q9BVG8
FLARTACTSVEEFQV

MTERF4

301

Q7Z6M4
LFFCELAQVIQLTCS

OR7G2

176

Q8NG99
NLFCSISVIFEVSQL

PKDREJ

1926

Q9NTG1
FLVCLFETESHSVVQ

FBXL18

751

Q96ME1
CATDTKNVQFVFDAV

GNAI2

326

P04899
SITVEECLAALQQVF

PNMA3

226

Q9UL41
VFFSEAVLTAANECV

SMG1

446

Q96Q15
CLVFDTSIAQLFAEN

SIAH1

256

Q8IUQ4
FQNVAAVCDLLSIVC

RNASE6

71

Q93091
VNRTLFDQVLEFLCS

VPS8

851

Q8N3P4
NTTFVNFDLINCVAI

PKHD1

2471

P08F94
SNIASFEEAFICLQK

SWT1

786

Q5T5J6
NFQDESCFVLSTIKA

TFCP2L1

451

Q9NZI6
NVFSQTTICRFEALQ

POU3F2

301

P20265
INTACFEAVVVTNTI

PRPS1L1

261

P21108
VDGINQFTSIFCLTV

SSTR2

121

P30874
QETFTFALTLVFIQC

SLC35B1

46

P78383
FALTLVFIQCVINAV

SLC35B1

51

P78383
SNFCTVALQFIEEEK

RPTOR

676

Q8N122
CFIITQANESFITIT

CMTM1

36

Q8IZ96
NVQDLFIEVQAFCIE

CNOT11

466

Q9UKZ1
FCASIEECRNIIVQF

CNOT1

266

A5YKK6
HVLETINFQTLTAFC

CNOT1

2006

A5YKK6
EVFCSVQRLSQAFID

RNF213

1611

Q63HN8
EALVFTSSINQSFCL

ZFAT

486

Q9P243
DCCLLQVTTLNFIFI

TMEM183A

291

Q8IXX5
CSVVDVFAQLNQSFE

UNC13C

1731

Q8NB66
LNADLIQVAFFTCSF

MINPP1

276

Q9UNW1
SAEQATALLSCFVFQ

MTREX

901

P42285
TALLSCFVFQENSSE

MTREX

906

P42285
EFQEFILDTLVLCLQ

RSPH14

166

Q9UHP6
FTQCFEHVSISIDQI

SMC1B

1066

Q8NDV3
DIALLDLINFFIQCS

STAG2

111

Q8N3U4
CEEAIIFLQNSFCSL

PLEKHG4B

356

Q96PX9
TLFCEVSVVQDSVNI

SPOPL

156

Q6IQ16
TLFCEVSVVQDSVNI

SPOP

156

O43791
FDSVQVVFTICTAVL

SPPL3

91

Q8TCT6
NAAIQELFTCVSEQF

TUBB8B

371

A6NNZ2
VCPVVANFEFELQLS

USP29

421

Q9HBJ7
ICLVDENQFTLTIAN

NF1

1791

P21359
ITAELNAFNVFVCDQ

VPS13C

1601

Q709C8
ACAAFLLLDVRFQQI

SYNGR3

81

O43761
ILFSFCEVCNIQLNS

ZNF385B

31

Q569K4
CFFTSASQDLQVIDL

THBS3

16

P49746
FEVASCITAATQQDF

UPK1B

101

O75841
LAQFALAFVTDTCVA

ZDHHC24

191

Q6UX98
FQLFLSKVEETFQCI

UHRF1

711

Q96T88
ELVFSHFVICNDTQE

VPS13B

2626

Q7Z7G8
INNACFEAVVVTNTI

PRPS1

261

P60891
EANVIVVGNCFSFVT

TMEM117

41

Q9H0C3
LNFVIDDSCINFVSL

ZMYM1

1036

Q5SVZ6
SAEVQVRLQFLTCVF

USP34

981

Q70CQ2
ICSCEFLSFTQEQQA

TLR2

536

O60603
EVFQVSLTVCFFKNI

TSPAN19

226

P0C672
LVTFKDVAVCFSQDQ

ZNF202

236

O95125
VVTLQDCLAAFFARD

USP33

566

Q8TEY7
SVCTDITNLIFNFLA

UFL1

576

O94874
LDQCDTIFTFVEKNV

THOC1

106

Q96FV9
EQCATAIFLLIFQSI

KCNJ1

151

P48048
LENCENFTFVSFTQV

KIAA1958

691

Q8N8K9
SLRVCIFSNNFITDI

LRRIQ3

51

A6PVS8