Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane transporter activity	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E SLC22A6 TRPM8 SLC35A3 SLC44A1 PIEZO2 SLC16A14 PIEZO1 SLC35B3	2.90e-11	1180	26	14	GO:0022857
GeneOntologyMolecularFunction	transporter activity	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E SLC22A6 TRPM8 SLC35A3 SLC44A1 PIEZO2 SLC16A14 PIEZO1 SLC35B3	9.44e-11	1289	26	14	GO:0005215
GeneOntologyMolecularFunction	gated channel activity	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E TRPM8 PIEZO2 PIEZO1	2.24e-10	334	26	9	GO:0022836
GeneOntologyMolecularFunction	monoatomic ion channel activity	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E TRPM8 PIEZO2 PIEZO1	3.66e-09	459	26	9	GO:0005216
GeneOntologyMolecularFunction	channel activity	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E TRPM8 PIEZO2 PIEZO1	1.18e-08	525	26	9	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E TRPM8 PIEZO2 PIEZO1	1.20e-08	526	26	9	GO:0022803
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1A CACNA1B CACNA1E	1.64e-07	9	26	3	GO:0099511
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1A CACNA1B CACNA1E	1.64e-07	9	26	3	GO:0099626
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E TRPM8 PIEZO2 PIEZO1	3.99e-07	793	26	9	GO:0015075
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1A CACNA1B CACNA1E	7.07e-07	14	26	3	GO:0008331
GeneOntologyMolecularFunction	GABA-gated chloride ion channel activity	GABRB1 GABRE GABRG1	1.58e-06	18	26	3	GO:0022851
GeneOntologyMolecularFunction	GABA-A receptor activity	GABRB1 GABRE GABRG1	1.87e-06	19	26	3	GO:0004890
GeneOntologyMolecularFunction	GABA receptor activity	GABRB1 GABRE GABRG1	2.97e-06	22	26	3	GO:0016917
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E SLC22A6 TRPM8	3.53e-06	758	26	8	GO:0015318
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	GABRB1 GABRE GABRG1 CCR3 ADRA2A C5AR1 MCHR1 OR52A4P CRHR2 AGTR1	3.84e-06	1353	26	10	GO:0004888
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1A CACNA1B CACNA1E TRPM8 PIEZO2 PIEZO1	4.24e-06	343	26	6	GO:0005261
GeneOntologyMolecularFunction	G protein-coupled receptor activity	GABRB1 CCR3 ADRA2A C5AR1 MCHR1 OR52A4P CRHR2 AGTR1	1.10e-05	884	26	8	GO:0004930
GeneOntologyMolecularFunction	calcium channel activity	CACNA1A CACNA1B CACNA1E TRPM8	2.23e-05	129	26	4	GO:0005262
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1A CACNA1B CACNA1E	2.87e-05	46	26	3	GO:0005245
GeneOntologyMolecularFunction	antiporter activity	SLC22A6 SLC35A3 SLC44A1 SLC35B3	2.90e-05	138	26	4	GO:0015297
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC22A6 SLC35A3 SLC44A1 SLC16A14 SLC35B3	3.53e-05	296	26	5	GO:0015291
GeneOntologyMolecularFunction	ligand-gated monoatomic anion channel activity	GABRB1 GABRE GABRG1	3.69e-05	50	26	3	GO:0099095
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1A CACNA1B CACNA1E TRPM8	4.13e-05	151	26	4	GO:0015085
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	GABRB1 GABRE GABRG1 SLC22A6	6.70e-05	171	26	4	GO:0015103
GeneOntologyMolecularFunction	transmitter-gated channel activity	GABRB1 GABRE GABRG1	8.11e-05	65	26	3	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	GABRB1 GABRE GABRG1	8.11e-05	65	26	3	GO:0022824
GeneOntologyMolecularFunction	benzodiazepine receptor activity	GABRE GABRG1	8.90e-05	11	26	2	GO:0008503
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	GABRB1 GABRE GABRG1 TRPM8	1.07e-04	193	26	4	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	GABRB1 GABRE GABRG1 TRPM8	1.16e-04	197	26	4	GO:0022834
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	GABRB1 GABRE GABRG1	1.34e-04	77	26	3	GO:0005230
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	CACNA1A CACNA1B CACNA1E TRPM8 PIEZO2 PIEZO1	1.72e-04	664	26	6	GO:0008324
GeneOntologyMolecularFunction	chloride channel activity	GABRB1 GABRE GABRG1	1.87e-04	86	26	3	GO:0005254
GeneOntologyMolecularFunction	mechanosensitive monoatomic ion channel activity	PIEZO2 PIEZO1	2.46e-04	18	26	2	GO:0008381
GeneOntologyMolecularFunction	neurotransmitter receptor activity	GABRB1 GABRE GABRG1	2.91e-04	100	26	3	GO:0030594
GeneOntologyMolecularFunction	GABA receptor binding	GABRB1 GABRG1	3.05e-04	20	26	2	GO:0050811
GeneOntologyMolecularFunction	hormone binding	ADRA2A MCHR1 CRHR2	3.18e-04	103	26	3	GO:0042562
GeneOntologyMolecularFunction	monoatomic anion channel activity	GABRB1 GABRE GABRG1	3.18e-04	103	26	3	GO:0005253
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC22A6 SLC35A3 SLC44A1 SLC16A14 SLC35B3	3.31e-04	477	26	5	GO:0022804
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC22A6 SLC35A3 SLC16A14 SLC35B3	5.26e-04	293	26	4	GO:0008514
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	GABRB1 GABRE GABRG1	5.60e-04	125	26	3	GO:0015108
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	MCHR1 CRHR2 AGTR1	6.71e-04	133	26	3	GO:0008528
GeneOntologyMolecularFunction	peptide receptor activity	MCHR1 CRHR2 AGTR1	7.79e-04	140	26	3	GO:0001653
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	GABRB1 GABRE GABRG1	9.70e-04	151	26	3	GO:0008509
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1A CACNA1B CACNA1E	9.89e-04	152	26	3	GO:0022843
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1A CACNA1B CACNA1E	1.66e-03	182	26	3	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1A CACNA1B CACNA1E	1.71e-03	184	26	3	GO:0022832
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GABRB1 GABRE	2.49e-03	57	26	2	GO:1904315
GeneOntologyMolecularFunction	carbohydrate derivative transmembrane transporter activity	SLC35A3 SLC35B3	2.67e-03	59	26	2	GO:1901505
GeneOntologyMolecularFunction	nucleobase-containing compound transmembrane transporter activity	SLC35A3 SLC35B3	2.67e-03	59	26	2	GO:0015932
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	GABRB1 GABRE	2.75e-03	60	26	2	GO:0099529
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1A CACNA1B CACNA1E TRPM8	2.89e-03	465	26	4	GO:0046873
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	GABRB1 GABRE	4.27e-03	75	26	2	GO:0098960
GeneOntologyMolecularFunction	amide binding	CACNA1A CACNA1B CRHR2	6.70e-03	299	26	3	GO:0033218
GeneOntologyMolecularFunction	amyloid-beta binding	CACNA1A CACNA1B	7.75e-03	102	26	2	GO:0001540
GeneOntologyMolecularFunction	peptide binding	CACNA1A CACNA1B MCHR1	7.93e-03	318	26	3	GO:0042277
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	CACNA1A CACNA1B CACNA1E TRPM8	8.31e-03	627	26	4	GO:0022890
GeneOntologyMolecularFunction	immune receptor activity	CCR3 C5AR1	1.94e-02	165	26	2	GO:0140375
GeneOntologyBiologicalProcess	monoatomic ion transport	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E SLC22A6 TRPM8 ADRA2A PIEZO2 MCHR1 CRHR2 PIEZO1 AGTR1	1.44e-10	1374	26	14	GO:0006811
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E TRPM8 ADRA2A PIEZO2 PIEZO1 AGTR1	4.00e-08	1115	26	11	GO:0034220
GeneOntologyBiologicalProcess	gamma-aminobutyric acid signaling pathway	GABRB1 GABRE CACNA1A GABRG1	1.01e-07	35	26	4	GO:0007214
GeneOntologyBiologicalProcess	calcium ion import	CACNA1A CACNA1B CACNA1E CRHR2 AGTR1	1.33e-07	98	26	5	GO:0070509
GeneOntologyBiologicalProcess	calcium ion transport	CACNA1A CACNA1B CACNA1E TRPM8 ADRA2A MCHR1 CRHR2 AGTR1	1.38e-07	509	26	8	GO:0006816
GeneOntologyBiologicalProcess	calcium ion import across plasma membrane	CACNA1A CACNA1B CACNA1E AGTR1	3.72e-07	48	26	4	GO:0098703
GeneOntologyBiologicalProcess	calcium ion import into cytosol	CACNA1A CACNA1B CACNA1E AGTR1	3.72e-07	48	26	4	GO:1902656
GeneOntologyBiologicalProcess	monoatomic cation transport	CACNA1A CACNA1B CACNA1E TRPM8 ADRA2A PIEZO2 MCHR1 CRHR2 PIEZO1 AGTR1	6.90e-07	1157	26	10	GO:0006812
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E TRPM8 ADRA2A AGTR1	2.43e-06	1017	26	9	GO:0098660
GeneOntologyBiologicalProcess	calcium ion transmembrane transport	CACNA1A CACNA1B CACNA1E TRPM8 ADRA2A AGTR1	7.57e-06	392	26	6	GO:0070588
GeneOntologyBiologicalProcess	positive regulation of cytosolic calcium ion concentration	CACNA1A CCR3 C5AR1 MCHR1 AGTR1	7.89e-06	224	26	5	GO:0007204
GeneOntologyBiologicalProcess	anterograde trans-synaptic signaling	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E ADRA2A CRHR2	1.26e-05	931	26	8	GO:0098916
GeneOntologyBiologicalProcess	chemical synaptic transmission	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E ADRA2A CRHR2	1.26e-05	931	26	8	GO:0007268
GeneOntologyBiologicalProcess	excretion	SLC22A6 CRHR2 AGTR1	1.34e-05	37	26	3	GO:0007588
GeneOntologyBiologicalProcess	trans-synaptic signaling	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E ADRA2A CRHR2	1.34e-05	939	26	8	GO:0099537
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	CACNA1A CACNA1B CACNA1E TRPM8 ADRA2A PIEZO2 PIEZO1 AGTR1	1.38e-05	942	26	8	GO:0098655
GeneOntologyBiologicalProcess	synaptic signaling	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E ADRA2A CRHR2	1.78e-05	976	26	8	GO:0099536
GeneOntologyBiologicalProcess	multicellular organismal response to stress	CACNA1A CACNA1B CACNA1E ADRA2A	1.79e-05	126	26	4	GO:0033555
GeneOntologyBiologicalProcess	metal ion transport	CACNA1A CACNA1B CACNA1E TRPM8 ADRA2A MCHR1 CRHR2 AGTR1	2.12e-05	1000	26	8	GO:0030001
GeneOntologyBiologicalProcess	amine transport	CACNA1A ADRA2A SLC44A1 CRHR2	2.49e-05	137	26	4	GO:0015837
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	CACNA1A CACNA1B CACNA1E AGTR1	2.86e-05	142	26	4	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	CACNA1A CACNA1B CACNA1E AGTR1	2.86e-05	142	26	4	GO:0098659
GeneOntologyBiologicalProcess	organic cation transport	CACNA1A ADRA2A SLC44A1 CRHR2	3.11e-05	145	26	4	GO:0015695
GeneOntologyBiologicalProcess	response to pain	CACNA1A CACNA1B CACNA1E	3.56e-05	51	26	3	GO:0048265
GeneOntologyBiologicalProcess	regulation of calcium ion transport	CACNA1B ADRA2A MCHR1 CRHR2 AGTR1	4.58e-05	323	26	5	GO:0051924
GeneOntologyBiologicalProcess	regulation of blood circulation	CACNA1B CACNA1E ADRA2A CRHR2 AGTR1	4.79e-05	326	26	5	GO:1903522
GeneOntologyBiologicalProcess	thermoception	TRPM8 ADRA2A	5.47e-05	9	26	2	GO:0050955
GeneOntologyBiologicalProcess	regulation of membrane potential	GABRB1 GABRE CACNA1A GABRG1 PIEZO2 PIEZO1	5.59e-05	559	26	6	GO:0042391
GeneOntologyBiologicalProcess	regulation of monoatomic ion transport	GABRE CACNA1B ADRA2A MCHR1 CRHR2 AGTR1	6.67e-05	577	26	6	GO:0043269
GeneOntologyBiologicalProcess	negative regulation of epinephrine secretion	ADRA2A CRHR2	6.83e-05	10	26	2	GO:0032811
GeneOntologyBiologicalProcess	inorganic anion transport	GABRB1 GABRE GABRG1 SLC22A6	7.22e-05	180	26	4	GO:0015698
GeneOntologyBiologicalProcess	monoatomic anion transport	GABRB1 GABRE GABRG1 SLC22A6	7.69e-05	183	26	4	GO:0006820
GeneOntologyBiologicalProcess	negative regulation of norepinephrine secretion	ADRA2A CRHR2	8.35e-05	11	26	2	GO:0010700
GeneOntologyBiologicalProcess	regulation of epinephrine secretion	ADRA2A CRHR2	8.35e-05	11	26	2	GO:0014060
GeneOntologyBiologicalProcess	behavior	CACNA1A CACNA1B CACNA1E MCHR1 NPHP4 CRHR2 AGTR1	8.76e-05	891	26	7	GO:0007610
GeneOntologyBiologicalProcess	synaptic transmission, GABAergic	GABRE CACNA1A GABRG1	1.09e-04	74	26	3	GO:0051932
GeneOntologyBiologicalProcess	epinephrine secretion	ADRA2A CRHR2	1.18e-04	13	26	2	GO:0048242
GeneOntologyBiologicalProcess	regulation of excretion	CRHR2 AGTR1	1.18e-04	13	26	2	GO:0044062
GeneOntologyBiologicalProcess	signal release	CACNA1A CACNA1B CACNA1E ADRA2A CRHR2 AGTR1	1.32e-04	653	26	6	GO:0023061
GeneOntologyBiologicalProcess	calcium ion transmembrane import into cytosol	CACNA1A CACNA1B CACNA1E AGTR1	1.49e-04	217	26	4	GO:0097553
GeneOntologyBiologicalProcess	import across plasma membrane	CACNA1A CACNA1B CACNA1E AGTR1	1.86e-04	230	26	4	GO:0098739
GeneOntologyBiologicalProcess	epinephrine transport	ADRA2A CRHR2	2.05e-04	17	26	2	GO:0048241
GeneOntologyBiologicalProcess	negative regulation of insulin secretion involved in cellular response to glucose stimulus	ADRA2A CRHR2	2.05e-04	17	26	2	GO:0061179
GeneOntologyBiologicalProcess	regulation of insulin secretion involved in cellular response to glucose stimulus	CACNA1E ADRA2A CRHR2	2.07e-04	92	26	3	GO:0061178
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	CCR3 ADRA2A C5AR1 MCHR1 OR52A4P CRHR2 TMEM145 AGTR1	2.23e-04	1395	26	8	GO:0007186
GeneOntologyBiologicalProcess	circulatory system process	CACNA1B CACNA1E ADRA2A SLC44A1 CRHR2 AGTR1	2.47e-04	733	26	6	GO:0003013
GeneOntologyBiologicalProcess	regulation of secretion by cell	CACNA1A CACNA1B CACNA1E ADRA2A CRHR2 AGTR1	2.60e-04	740	26	6	GO:1903530
GeneOntologyBiologicalProcess	insulin secretion involved in cellular response to glucose stimulus	CACNA1E ADRA2A CRHR2	2.81e-04	102	26	3	GO:0035773
GeneOntologyBiologicalProcess	positive regulation of monoatomic ion transport	ADRA2A MCHR1 CRHR2 AGTR1	3.23e-04	266	26	4	GO:0043270
GeneOntologyBiologicalProcess	regulation of metal ion transport	CACNA1B ADRA2A MCHR1 CRHR2 AGTR1	3.32e-04	493	26	5	GO:0010959
GeneOntologyBiologicalProcess	chloride transmembrane transport	GABRB1 GABRE GABRG1	3.70e-04	112	26	3	GO:1902476
GeneOntologyBiologicalProcess	renal tubular secretion	SLC22A6 AGTR1	3.80e-04	23	26	2	GO:0097254
GeneOntologyBiologicalProcess	negative regulation of catecholamine secretion	ADRA2A CRHR2	3.80e-04	23	26	2	GO:0033604
GeneOntologyBiologicalProcess	regulation of secretion	CACNA1A CACNA1B CACNA1E ADRA2A CRHR2 AGTR1	3.98e-04	801	26	6	GO:0051046
GeneOntologyBiologicalProcess	organic anion transport	CACNA1A SLC22A6 SLC35A3 SLC16A14 SLC35B3	4.05e-04	515	26	5	GO:0015711
GeneOntologyBiologicalProcess	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	CCR3 ADRA2A MCHR1 CRHR2	4.25e-04	286	26	4	GO:0007188
GeneOntologyBiologicalProcess	regulation of neurotransmitter secretion	CACNA1A CACNA1B CACNA1E	4.31e-04	118	26	3	GO:0046928
GeneOntologyBiologicalProcess	regulated exocytosis	CACNA1A CACNA1B CACNA1E ADRA2A	4.54e-04	291	26	4	GO:0045055
GeneOntologyBiologicalProcess	regulation of norepinephrine secretion	ADRA2A CRHR2	4.87e-04	26	26	2	GO:0014061
GeneOntologyBiologicalProcess	synaptic vesicle exocytosis	CACNA1A CACNA1B CACNA1E	5.10e-04	125	26	3	GO:0016079
GeneOntologyBiologicalProcess	regulation of amine transport	CACNA1A ADRA2A CRHR2	5.10e-04	125	26	3	GO:0051952
GeneOntologyBiologicalProcess	chloride transport	GABRB1 GABRE GABRG1	5.47e-04	128	26	3	GO:0006821
GeneOntologyBiologicalProcess	norepinephrine secretion	ADRA2A CRHR2	5.66e-04	28	26	2	GO:0048243
GeneOntologyBiologicalProcess	catechol-containing compound biosynthetic process	CRHR2 AGTR1	6.07e-04	29	26	2	GO:0009713
GeneOntologyBiologicalProcess	catecholamine biosynthetic process	CRHR2 AGTR1	6.07e-04	29	26	2	GO:0042423
GeneOntologyBiologicalProcess	phospholipase C-activating G protein-coupled receptor signaling pathway	ADRA2A C5AR1 AGTR1	6.11e-04	133	26	3	GO:0007200
GeneOntologyBiologicalProcess	inorganic anion transmembrane transport	GABRB1 GABRE GABRG1	6.25e-04	134	26	3	GO:0098661
GeneOntologyBiologicalProcess	inhibitory synapse assembly	GABRE GABRG1	6.50e-04	30	26	2	GO:1904862
GeneOntologyBiologicalProcess	regulation of neurotransmitter transport	CACNA1A CACNA1B CACNA1E	7.25e-04	141	26	3	GO:0051588
GeneOntologyBiologicalProcess	behavioral response to pain	CACNA1A CACNA1E	7.40e-04	32	26	2	GO:0048266
GeneOntologyBiologicalProcess	glucose homeostasis	CACNA1A CACNA1E ADRA2A CRHR2	7.96e-04	338	26	4	GO:0042593
GeneOntologyBiologicalProcess	carbohydrate homeostasis	CACNA1A CACNA1E ADRA2A CRHR2	8.05e-04	339	26	4	GO:0033500
GeneOntologyBiologicalProcess	amine metabolic process	SLC44A1 CRHR2 AGTR1	8.34e-04	148	26	3	GO:0009308
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	CACNA1A CACNA1B CACNA1E TRPM8 ADRA2A AGTR1	8.37e-04	922	26	6	GO:0098662
GeneOntologyBiologicalProcess	monoatomic anion transmembrane transport	GABRB1 GABRE GABRG1	9.18e-04	153	26	3	GO:0098656
GeneOntologyBiologicalProcess	regulation of hormone secretion	CACNA1E ADRA2A CRHR2 AGTR1	9.56e-04	355	26	4	GO:0046883
GeneOntologyBiologicalProcess	organic hydroxy compound transport	ADRA2A SLC44A1 CRHR2 AGTR1	9.86e-04	358	26	4	GO:0015850
GeneOntologyBiologicalProcess	sensory perception of temperature stimulus	TRPM8 ADRA2A	1.04e-03	38	26	2	GO:0050951
GeneOntologyBiologicalProcess	norepinephrine transport	ADRA2A CRHR2	1.04e-03	38	26	2	GO:0015874
GeneOntologyBiologicalProcess	feeding behavior	MCHR1 CRHR2 AGTR1	1.08e-03	162	26	3	GO:0007631
GeneOntologyBiologicalProcess	regulation of regulated secretory pathway	CACNA1A CACNA1E ADRA2A	1.14e-03	165	26	3	GO:1903305
GeneOntologyBiologicalProcess	blood circulation	CACNA1B CACNA1E ADRA2A CRHR2 AGTR1	1.15e-03	648	26	5	GO:0008015
GeneOntologyBiologicalProcess	negative regulation of monoatomic ion transport	GABRE ADRA2A CRHR2	1.27e-03	171	26	3	GO:0043271
GeneOntologyBiologicalProcess	modulation of chemical synaptic transmission	CACNA1A CACNA1B CACNA1E ADRA2A CRHR2	1.27e-03	663	26	5	GO:0050804
GeneOntologyBiologicalProcess	regulation of trans-synaptic signaling	CACNA1A CACNA1B CACNA1E ADRA2A CRHR2	1.28e-03	664	26	5	GO:0099177
GeneOntologyBiologicalProcess	negative regulation of amine transport	ADRA2A CRHR2	1.34e-03	43	26	2	GO:0051953
GeneOntologyBiologicalProcess	regulation of hormone levels	CACNA1A CACNA1E ADRA2A CRHR2 AGTR1	1.46e-03	684	26	5	GO:0010817
GeneOntologyBiologicalProcess	regulation of calcium ion-dependent exocytosis	CACNA1A ADRA2A	1.46e-03	45	26	2	GO:0017158
GeneOntologyBiologicalProcess	regulation of postsynaptic membrane potential	GABRB1 GABRE GABRG1	1.47e-03	180	26	3	GO:0060078
GeneOntologyBiologicalProcess	biogenic amine biosynthetic process	CRHR2 AGTR1	1.60e-03	47	26	2	GO:0042401
GeneOntologyBiologicalProcess	amine biosynthetic process	CRHR2 AGTR1	1.66e-03	48	26	2	GO:0009309
GeneOntologyBiologicalProcess	secretion by cell	CACNA1A CACNA1B CACNA1E ADRA2A CRHR2 AGTR1	1.76e-03	1064	26	6	GO:0032940
GeneOntologyBiologicalProcess	regulation of angiogenesis	CCR3 C5AR1 CRHR2 AGTR1	1.78e-03	420	26	4	GO:0045765
GeneOntologyBiologicalProcess	hormone secretion	CACNA1E ADRA2A CRHR2 AGTR1	1.78e-03	420	26	4	GO:0046879
GeneOntologyBiologicalProcess	sensory perception	CACNA1E TRPM8 ADRA2A PIEZO2 C5AR1 OR52A4P	1.82e-03	1072	26	6	GO:0007600
GeneOntologyBiologicalProcess	signal release from synapse	CACNA1A CACNA1B CACNA1E	1.84e-03	195	26	3	GO:0099643
GeneOntologyBiologicalProcess	neurotransmitter secretion	CACNA1A CACNA1B CACNA1E	1.84e-03	195	26	3	GO:0007269
GeneOntologyCellularComponent	GABA-A receptor complex	GABRB1 GABRE GABRG1	1.63e-06	19	26	3	GO:1902711
GeneOntologyCellularComponent	GABA receptor complex	GABRB1 GABRE GABRG1	2.24e-06	21	26	3	GO:1902710
GeneOntologyCellularComponent	monoatomic ion channel complex	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E	5.70e-06	378	26	6	GO:0034702
GeneOntologyCellularComponent	postsynaptic membrane	GABRB1 GABRE CACNA1A GABRG1 CACNA1E ADRA2A	8.45e-06	405	26	6	GO:0045211
GeneOntologyCellularComponent	somatodendritic compartment	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E ADRA2A CRHR2 AGTR1	1.02e-05	1228	26	9	GO:0036477
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1A CACNA1B CACNA1E	2.50e-05	46	26	3	GO:0005891
GeneOntologyCellularComponent	presynaptic active zone	GABRB1 CACNA1A CACNA1B ADRA2A	2.64e-05	141	26	4	GO:0048786
GeneOntologyCellularComponent	transmembrane transporter complex	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E	3.58e-05	523	26	6	GO:1902495
GeneOntologyCellularComponent	transporter complex	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E	4.74e-05	550	26	6	GO:1990351
GeneOntologyCellularComponent	GABA-ergic synapse	GABRB1 GABRE CACNA1E ADRA2A	4.77e-05	164	26	4	GO:0098982
GeneOntologyCellularComponent	chloride channel complex	GABRB1 GABRE GABRG1	4.78e-05	57	26	3	GO:0034707
GeneOntologyCellularComponent	dendrite	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CRHR2 AGTR1	6.35e-05	858	26	7	GO:0030425
GeneOntologyCellularComponent	dendritic tree	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CRHR2 AGTR1	6.45e-05	860	26	7	GO:0097447
GeneOntologyCellularComponent	synaptic membrane	GABRB1 GABRE CACNA1A GABRG1 CACNA1E ADRA2A	6.56e-05	583	26	6	GO:0097060
GeneOntologyCellularComponent	calcium channel complex	CACNA1A CACNA1B CACNA1E	1.00e-04	73	26	3	GO:0034704
GeneOntologyCellularComponent	presynaptic active zone membrane	GABRB1 CACNA1A ADRA2A	1.22e-04	78	26	3	GO:0048787
GeneOntologyCellularComponent	presynaptic membrane	GABRB1 CACNA1A CACNA1E ADRA2A	3.58e-04	277	26	4	GO:0042734
GeneOntologyCellularComponent	basolateral plasma membrane	SLC22A6 ADRA2A C5AR1 AGTR1	6.17e-04	320	26	4	GO:0016323
GeneOntologyCellularComponent	presynapse	GABRB1 CACNA1A CACNA1B CACNA1E ADRA2A CRHR2	6.33e-04	886	26	6	GO:0098793
GeneOntologyCellularComponent	basal plasma membrane	SLC22A6 ADRA2A C5AR1 AGTR1	9.00e-04	354	26	4	GO:0009925
GeneOntologyCellularComponent	basal part of cell	SLC22A6 ADRA2A C5AR1 AGTR1	1.15e-03	378	26	4	GO:0045178
GeneOntologyCellularComponent	postsynapse	GABRB1 GABRE CACNA1A GABRG1 CACNA1E ADRA2A	1.31e-03	1018	26	6	GO:0098794
GeneOntologyCellularComponent	cell projection membrane	GABRE GABRG1 MCHR1 PIEZO1	1.86e-03	431	26	4	GO:0031253
GeneOntologyCellularComponent	axon terminus	CACNA1B ADRA2A CRHR2	2.19e-03	210	26	3	GO:0043679
GeneOntologyCellularComponent	leading edge membrane	GABRE GABRG1 PIEZO1	2.19e-03	210	26	3	GO:0031256
GeneOntologyCellularComponent	dendrite membrane	GABRE GABRG1	2.20e-03	56	26	2	GO:0032590
GeneOntologyCellularComponent	perikaryon	CACNA1A CACNA1E CRHR2	2.60e-03	223	26	3	GO:0043204
GeneOntologyCellularComponent	neuron projection terminus	CACNA1B ADRA2A CRHR2	2.94e-03	233	26	3	GO:0044306
GeneOntologyCellularComponent	cation channel complex	CACNA1A CACNA1B CACNA1E	3.01e-03	235	26	3	GO:0034703
GeneOntologyCellularComponent	neuronal cell body	CACNA1A CACNA1B CACNA1E ADRA2A CRHR2	3.28e-03	835	26	5	GO:0043025
GeneOntologyCellularComponent	neuron projection membrane	GABRE GABRG1	4.65e-03	82	26	2	GO:0032589
GeneOntologyCellularComponent	cell body	CACNA1A CACNA1B CACNA1E ADRA2A CRHR2	5.18e-03	929	26	5	GO:0044297
GeneOntologyCellularComponent	receptor complex	GABRB1 GABRE GABRG1 ADRA2A	5.43e-03	581	26	4	GO:0043235
GeneOntologyCellularComponent	membrane protein complex	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E	8.89e-03	1498	26	6	GO:0098796
GeneOntologyCellularComponent	Schaffer collateral - CA1 synapse	GABRB1 CACNA1B	1.58e-02	155	26	2	GO:0098685
GeneOntologyCellularComponent	distal axon	CACNA1B ADRA2A CRHR2	1.63e-02	435	26	3	GO:0150034
MousePheno	abnormal channel response	CACNA1A CACNA1B CACNA1E	1.55e-05	33	21	3	MP:0003484
MousePheno	increased heart rate	CACNA1B ADRA2A SLC44A1 MCHR1	2.76e-05	120	21	4	MP:0002626
MousePheno	abnormal heart rate	GABRE CACNA1B ADRA2A SLC44A1 MCHR1 AGTR1	3.63e-05	445	21	6	MP:0001629
MousePheno	abnormal heartbeat	GABRE CACNA1B ADRA2A SLC44A1 MCHR1 AGTR1	7.05e-05	501	21	6	MP:0004085
MousePheno	abnormal behavioral response to xenobiotic	GABRB1 GABRE CACNA1A CACNA1B MCHR1	7.77e-05	309	21	5	MP:0009745
MousePheno	abnormal drinking behavior	GABRB1 CACNA1B MCHR1 AGTR1	8.29e-05	159	21	4	MP:0001422
MousePheno	abnormal hormone level	GABRB1 CACNA1A CACNA1B CACNA1E ADRA2A MCHR1 CRHR2 AGTR1	9.66e-05	1073	21	8	MP:0003953
MousePheno	enhanced behavioral response to xenobiotic	GABRB1 CACNA1A CACNA1B	1.44e-04	69	21	3	MP:0009746
MousePheno	impaired behavioral response to xenobiotic	GABRE CACNA1B MCHR1	2.49e-04	83	21	3	MP:0009747
MousePheno	enhanced behavioral response to alcohol	GABRB1 CACNA1B	2.55e-04	16	21	2	MP:0009751
MousePheno	abnormal frequency of paradoxical sleep	CACNA1B MCHR1	3.62e-04	19	21	2	MP:0003194
MousePheno	decreased circulating glucagon level	CACNA1B CACNA1E	4.02e-04	20	21	2	MP:0002696
MousePheno	abnormal systemic arterial blood pressure	CACNA1B ADRA2A CRHR2 AGTR1	4.36e-04	245	21	4	MP:0000230
MousePheno	abnormal paradoxical sleep pattern	CACNA1B MCHR1	5.34e-04	23	21	2	MP:0012288
MousePheno	abnormal spike wave discharge	CACNA1A ADRA2A	5.82e-04	24	21	2	MP:0008840
MousePheno	abnormal behavioral response to alcohol	GABRB1 CACNA1B	5.82e-04	24	21	2	MP:0020157
MousePheno	abnormal pain threshold	CACNA1A GABRG1 CACNA1B TRPM8	6.03e-04	267	21	4	MP:0001970
MousePheno	abnormal synaptic transmission	GABRB1 CACNA1A CACNA1B CACNA1E ADRA2A SLC44A1 TMEM145	6.75e-04	1070	21	7	MP:0003635
MousePheno	abnormal synaptic physiology	GABRB1 CACNA1A CACNA1B CACNA1E ADRA2A SLC44A1 TMEM145	6.98e-04	1076	21	7	MP:0021009
MousePheno	abnormal liquid preference	GABRB1 CACNA1B	9.74e-04	31	21	2	MP:0001423
MousePheno	abnormal fluid intake	CACNA1B MCHR1 AGTR1	1.05e-03	136	21	3	MP:0011947
MousePheno	abnormal alcohol consumption	GABRB1 CACNA1B	1.24e-03	35	21	2	MP:0001425
MousePheno	abnormal single cell response	GABRB1 CACNA1B	1.24e-03	35	21	2	MP:0003463
MousePheno	absence seizures	CACNA1A ADRA2A	1.24e-03	35	21	2	MP:0003216
MousePheno	abnormal nervous system electrophysiology	GABRB1 CACNA1A CACNA1B MCHR1	1.31e-03	329	21	4	MP:0002272
MousePheno	nonconvulsive seizures	CACNA1A ADRA2A	1.62e-03	40	21	2	MP:0000948
MousePheno	abnormal circulating glucagon level	CACNA1B CACNA1E	1.62e-03	40	21	2	MP:0002695
MousePheno	increased systemic arterial blood pressure	CACNA1B CRHR2 AGTR1	1.62e-03	158	21	3	MP:0002842
MousePheno	abnormal thermal nociception	CACNA1A CACNA1B TRPM8	1.93e-03	168	21	3	MP:0002733
MousePheno	enhanced behavioral response to addictive substance	GABRB1 CACNA1B	1.96e-03	44	21	2	MP:0009749
MousePheno	hypoalgesia	CACNA1A CACNA1B TRPM8	2.00e-03	170	21	3	MP:0003043
MousePheno	hyporesponsive to tactile stimuli	CACNA1A CACNA1B	2.05e-03	45	21	2	MP:0005498
MousePheno	decreased hormone level	GABRB1 CACNA1B CACNA1E MCHR1 AGTR1	2.11e-03	635	21	5	MP:0014455
MousePheno	abnormal touch/ nociception	CACNA1A GABRG1 CACNA1B TRPM8	2.14e-03	376	21	4	MP:0001968
Domain	Ca_chan_IQ	CACNA1A CACNA1B CACNA1E	8.35e-08	7	26	3	PF08763
Domain	GPHH	CACNA1A CACNA1B CACNA1E	8.35e-08	7	26	3	PF16905
Domain	GPHH_dom	CACNA1A CACNA1B CACNA1E	8.35e-08	7	26	3	IPR031649
Domain	VDCC_a1su_IQ	CACNA1A CACNA1B CACNA1E	8.35e-08	7	26	3	IPR014873
Domain	Ca_chan_IQ	CACNA1A CACNA1B CACNA1E	8.35e-08	7	26	3	SM01062
Domain	VDCCAlpha1	CACNA1A CACNA1B CACNA1E	2.86e-07	10	26	3	IPR002077
Domain	Piezo	PIEZO2 PIEZO1	1.86e-06	2	26	2	IPR027272
Domain	Piezo_dom	PIEZO2 PIEZO1	1.86e-06	2	26	2	IPR031805
Domain	Piezo_RRas_bdg	PIEZO2 PIEZO1	1.86e-06	2	26	2	PF12166
Domain	PIEZO	PIEZO2 PIEZO1	1.86e-06	2	26	2	PF15917
Domain	Piezo_RRas-bd_dom	PIEZO2 PIEZO1	1.86e-06	2	26	2	IPR031334
Domain	GABAA/Glycine_rcpt	GABRB1 GABRE GABRG1	4.16e-06	23	26	3	IPR006028
Domain	Ion_trans_dom	CACNA1A CACNA1B CACNA1E TRPM8	1.77e-05	114	26	4	IPR005821
Domain	Ion_trans	CACNA1A CACNA1B CACNA1E TRPM8	1.77e-05	114	26	4	PF00520
Domain	Neurotransmitter_ion_chnl_CS	GABRB1 GABRE GABRG1	3.27e-05	45	26	3	IPR018000
Domain	Neur_chan_memb	GABRB1 GABRE GABRG1	3.49e-05	46	26	3	PF02932
Domain	Neur_chan_LBD	GABRB1 GABRE GABRG1	3.73e-05	47	26	3	PF02931
Domain	Neur_channel	GABRB1 GABRE GABRG1	3.73e-05	47	26	3	IPR006201
Domain	Neur_chan_lig-bd	GABRB1 GABRE GABRG1	3.73e-05	47	26	3	IPR006202
Domain	Neurotrans-gated_channel_TM	GABRB1 GABRE GABRG1	3.73e-05	47	26	3	IPR006029
Domain	NEUROTR_ION_CHANNEL	GABRB1 GABRE GABRG1	3.73e-05	47	26	3	PS00236
Domain	-	GABRB1 GABRE GABRG1	3.73e-05	47	26	3	2.70.170.10
Domain	Channel_four-helix_dom	CACNA1A CACNA1B CACNA1E	6.67e-05	57	26	3	IPR027359
Domain	-	CACNA1A CACNA1B CACNA1E	6.67e-05	57	26	3	1.20.120.350
Domain	GPCR_Rhodpsn_7TM	CCR3 ADRA2A C5AR1 MCHR1 OR52A4P AGTR1	2.59e-04	670	26	6	IPR017452
Domain	7tm_1	CCR3 ADRA2A C5AR1 MCHR1 OR52A4P AGTR1	2.74e-04	677	26	6	PF00001
Domain	G_PROTEIN_RECEP_F1_1	CCR3 ADRA2A C5AR1 MCHR1 OR52A4P AGTR1	2.92e-04	685	26	6	PS00237
Domain	G_PROTEIN_RECEP_F1_2	CCR3 ADRA2A C5AR1 MCHR1 OR52A4P AGTR1	3.06e-04	691	26	6	PS50262
Domain	GPCR_Rhodpsn	CCR3 ADRA2A C5AR1 MCHR1 OR52A4P AGTR1	3.09e-04	692	26	6	IPR000276
Domain	MFS	SLC22A6 SLC16A14	9.84e-03	108	26	2	PS50850
Domain	7TM_GPCR_Srsx	ADRA2A AGTR1	1.05e-02	112	26	2	SM01381
Domain	MFS_dom	SLC22A6 SLC16A14	1.48e-02	134	26	2	IPR020846
Domain	EF_HAND_2	CACNA1B CACNA1E	4.07e-02	231	26	2	PS50222
Domain	EF_hand_dom	CACNA1B CACNA1E	4.11e-02	232	26	2	IPR002048
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	GABRB1 GABRE GABRG1 ADRA2A C5AR1 MCHR1 CRHR2 AGTR1	1.79e-09	272	20	8	M13380
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	CACNA1A CACNA1B CACNA1E	4.00e-07	11	20	3	M47958
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1A CACNA1B CACNA1E	4.00e-07	11	20	3	MM14498
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1A CACNA1B CACNA1E	4.00e-07	11	20	3	M26913
Pathway	WP_GPCRS_NONODORANT	CCR3 ADRA2A C5AR1 MCHR1 CRHR2 AGTR1	1.32e-06	266	20	6	MM15843
Pathway	KEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1A CACNA1B CACNA1E	4.25e-06	23	20	3	M47666
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNA1A CACNA1B CACNA1E	5.51e-06	25	20	3	M47948
Pathway	WP_GABA_RECEPTOR_SIGNALING	GABRB1 GABRE GABRG1	1.07e-05	31	20	3	M39369
Pathway	WP_MBDNF_AND_PROBDNF_REGULATION_OF_GABA_NEUROTRANSMISSION	GABRB1 GABRE GABRG1	2.00e-05	38	20	3	M39854
Pathway	REACTOME_GPCR_LIGAND_BINDING	CCR3 ADRA2A C5AR1 MCHR1 CRHR2 AGTR1	2.10e-05	430	20	6	MM15160
Pathway	REACTOME_GPCR_LIGAND_BINDING	CCR3 ADRA2A C5AR1 MCHR1 CRHR2 AGTR1	3.18e-05	463	20	6	M507
Pathway	KEGG_TYPE_II_DIABETES_MELLITUS	CACNA1A CACNA1B CACNA1E	3.81e-05	47	20	3	M19708
Pathway	REACTOME_TRANSPORT_OF_NUCLEOTIDE_SUGARS	SLC35A3 SLC35B3	6.84e-05	9	20	2	MM15421
Pathway	REACTOME_TRANSPORT_OF_NUCLEOTIDE_SUGARS	SLC35A3 SLC35B3	6.84e-05	9	20	2	M27688
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	CCR3 ADRA2A C5AR1 MCHR1 AGTR1	7.92e-05	330	20	5	M18334
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	CCR3 ADRA2A C5AR1 MCHR1 AGTR1	8.26e-05	333	20	5	MM14963
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	CACNA1A CACNA1E ADRA2A	8.34e-05	61	20	3	MM15071
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	CACNA1A CACNA1B CACNA1E AGTR1	1.02e-04	178	20	4	M2890
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	CCR3 ADRA2A C5AR1 AGTR1	1.20e-04	186	20	4	MM15994
Pathway	WP_GPCRS_PEPTIDE	CCR3 C5AR1 AGTR1	1.26e-04	70	20	3	MM15959
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	CACNA1A CACNA1E ADRA2A	1.37e-04	72	20	3	MM14631
Pathway	WP_DRAVET_SYNDROME_SCN1AA1783V_POINT_MUTATION_MODEL	GABRB1 CACNA1A CACNA1B	1.43e-04	73	20	3	MM16641
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	CCR3 C5AR1 MCHR1 AGTR1	1.50e-04	197	20	4	M12289
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	CCR3 C5AR1 MCHR1 AGTR1	1.50e-04	197	20	4	MM14970
Pathway	WP_PEPTIDE_GPCRS	CCR3 C5AR1 AGTR1	1.55e-04	75	20	3	M39696
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	CACNA1A CACNA1E ADRA2A	1.74e-04	78	20	3	M1921
Pathway	REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	GABRB1 CACNA1A CACNA1B CACNA1E	1.96e-04	211	20	4	MM14502
Pathway	REACTOME_SIGNALING_BY_GPCR	CCR3 ADRA2A C5AR1 MCHR1 CRHR2 AGTR1	2.02e-04	646	20	6	MM14962
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC22A6 SLC35A3 SLC44A1 SLC35B3	3.10e-04	238	20	4	MM15076
Pathway	REACTOME_SIGNALING_BY_GPCR	CCR3 ADRA2A C5AR1 MCHR1 CRHR2 AGTR1	3.17e-04	702	20	6	M746
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC22A6 SLC35A3 SLC44A1 SLC35B3	3.68e-04	249	20	4	M5988
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	CCR3 ADRA2A MCHR1 AGTR1	4.34e-04	260	20	4	M39397
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	CACNA1A CACNA1E ADRA2A	4.53e-04	108	20	3	M17034
Pathway	REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	GABRB1 CACNA1A CACNA1B CACNA1E	5.01e-04	270	20	4	M15514
Pathway	WP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS	GABRB1 GABRE GABRG1	6.02e-04	119	20	3	M48309
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	CCR3 ADRA2A C5AR1 MCHR1	6.47e-04	289	20	4	MM15057
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	CCR3 ADRA2A C5AR1 MCHR1	8.82e-04	314	20	4	M600
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	CACNA1A CACNA1B CACNA1E	1.11e-03	147	20	3	MM15854
Pathway	REACTOME_NEURONAL_SYSTEM	GABRB1 CACNA1A CACNA1B CACNA1E	1.12e-03	335	20	4	MM14503
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	CACNA1A CACNA1B CACNA1E	1.20e-03	151	20	3	M39329
Pathway	REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES	SLC35A3 SLC35B3	1.52e-03	41	20	2	MM15075
Pathway	REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES	SLC35A3 SLC35B3	1.67e-03	43	20	2	M881
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC22A6 TRPM8 SLC35A3 SLC44A1 SLC35B3	2.19e-03	681	20	5	MM14985
Pathway	WP_SYNAPTIC_VESICLE_PATHWAY	CACNA1A CACNA1B	2.34e-03	51	20	2	M39457
Pathway	REACTOME_NEURONAL_SYSTEM	GABRB1 CACNA1A CACNA1B CACNA1E	2.38e-03	411	20	4	M735
Pathway	KEGG_TASTE_TRANSDUCTION	CACNA1A CACNA1B	2.43e-03	52	20	2	M5785
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC22A6 TRPM8 SLC35A3 SLC44A1 SLC35B3	3.08e-03	736	20	5	M27287
Pathway	WP_MAPK_SIGNALING	CACNA1A CACNA1B CACNA1E	4.80e-03	246	20	3	M39597
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC22A6 SLC44A1	5.12e-03	76	20	2	MM15072
Pathway	KEGG_MAPK_SIGNALING_PATHWAY	CACNA1A CACNA1B CACNA1E	6.03e-03	267	20	3	M10792
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC22A6 SLC44A1	6.22e-03	84	20	2	M27334
Pathway	WP_ADHD_AND_AUTISM_ASD_PATHWAYS	GABRB1 GABRG1 AGTR1	1.44e-02	367	20	3	M48346
Pubmed	The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.	CACNA1A CACNA1B CACNA1E	3.71e-10	3	26	3	38996073
Pubmed	Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.	CACNA1A CACNA1B CACNA1E	3.71e-10	3	26	3	24523520
Pubmed	Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.	CACNA1A CACNA1B CACNA1E	1.48e-09	4	26	3	32616470
Pubmed	Cerebellar granule cell signaling is indispensable for normal motor performance.	CACNA1A CACNA1B CACNA1E	1.48e-09	4	26	3	37141091
Pubmed	Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.	CACNA1A CACNA1B CACNA1E	3.70e-09	5	26	3	8825650
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1A CACNA1B CACNA1E	3.70e-09	5	26	3	11296258
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1A CACNA1B CACNA1E	3.70e-09	5	26	3	15451373
Pubmed	An action potential initiation mechanism in distal axons for the control of dopamine release.	CACNA1A CACNA1B CACNA1E	7.41e-09	6	26	3	35324301
Pubmed	Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.	CACNA1A CACNA1B CACNA1E	7.41e-09	6	26	3	9238069
Pubmed	Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.	CACNA1A CACNA1B CACNA1E	7.41e-09	6	26	3	12827191
Pubmed	Rebuilding essential active zone functions within a synapse.	CACNA1A CACNA1B CACNA1E	1.30e-08	7	26	3	35176221
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1A CACNA1B CACNA1E	3.11e-08	9	26	3	16382099
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1A CACNA1B CACNA1E	1.68e-07	15	26	3	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1A CACNA1B CACNA1E	1.68e-07	15	26	3	24453333
Pubmed	Dissociation of heterotrimeric g proteins in cells.	CCR3 ADRA2A MCHR1 CRHR2 AGTR1	2.06e-07	179	26	5	18577758
Pubmed	A vagal reflex evoked by airway closure.	PIEZO2 CRHR2 PIEZO1	2.06e-07	16	26	3	38448588
Pubmed	Association study of 182 candidate genes in anorexia nervosa.	GABRB1 GABRE GABRG1 ADRA2A CRHR2	2.23e-07	182	26	5	20468064
Pubmed	Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.	GABRB1 GABRE GABRG1	3.00e-07	18	26	3	19078961
Pubmed	Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.	CCR3 ADRA2A C5AR1 CRHR2 AGTR1	3.57e-07	200	26	5	18240029
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	GABRB1 CACNA1A CACNA1E SLC44A1 MCHR1 TMEM145	4.54e-07	405	26	6	38187761
Pubmed	Piezo proteins: incidence and abundance in the enteric nervous system. Is there a link with mechanosensitivity?	PIEZO2 PIEZO1	5.37e-07	2	26	2	30324494
Pubmed	Blocking the R-type (Cav2.3) Ca2+ channel enhanced morphine analgesia and reduced morphine tolerance.	CACNA1B CACNA1E	5.37e-07	2	26	2	15610184
Pubmed	Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.	CACNA1A CACNA1B	5.37e-07	2	26	2	23426690
Pubmed	[Feeling the pressure? Identification of two proteins activated by mechanical forces].	PIEZO2 PIEZO1	5.37e-07	2	26	2	21299953
Pubmed	The transient receptor potential channel TRPM8 is inhibited via the alpha 2A adrenoreceptor signaling pathway.	TRPM8 ADRA2A	5.37e-07	2	26	2	20110357
Pubmed	Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice.	CACNA1A CACNA1E	5.37e-07	2	26	2	16381801
Pubmed	Mechanosensitive channels: in touch with Piezo.	PIEZO2 PIEZO1	5.37e-07	2	26	2	21056836
Pubmed	CaV 2.1 α1 subunit motifs that control presynaptic CaV 2.1 subtype abundance are distinct from CaV 2.1 preference.	CACNA1A CACNA1B	5.37e-07	2	26	2	38155373
Pubmed	Effects of ablation of N- and R-type Ca(2+) channels on pain transmission.	CACNA1B CACNA1E	5.37e-07	2	26	2	12074836
Pubmed	Loss of stretch-activated channels, PIEZOs, accelerates non-small cell lung cancer progression and cell migration.	PIEZO2 PIEZO1	5.37e-07	2	26	2	30745454
Pubmed	The role of PIEZO ion channels in the musculoskeletal system.	PIEZO2 PIEZO1	5.37e-07	2	26	2	36717101
Pubmed	Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.	PIEZO2 PIEZO1	5.37e-07	2	26	2	38395992
Pubmed	Differential expression of PIEZO1 and PIEZO2 mechanosensitive channels in ocular tissues implicates diverse functional roles.	PIEZO2 PIEZO1	5.37e-07	2	26	2	37820892
Pubmed	Astrocytes in the optic nerve head express putative mechanosensitive channels.	PIEZO2 PIEZO1	5.37e-07	2	26	2	26236150
Pubmed	Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.	PIEZO2 PIEZO1	5.37e-07	2	26	2	27743844
Pubmed	Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause's Corpuscles.	PIEZO2 PIEZO1	5.37e-07	2	26	2	38928429
Pubmed	Mechanisms of mechanotransduction and physiological roles of PIEZO channels.	PIEZO2 PIEZO1	5.37e-07	2	26	2	39251883
Pubmed	A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels.	PIEZO2 PIEZO1	5.37e-07	2	26	2	30628892
Pubmed	Piezo1 ion channel pore properties are dictated by C-terminal region.	PIEZO2 PIEZO1	5.37e-07	2	26	2	26008989
Pubmed	Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.	PIEZO2 PIEZO1	5.37e-07	2	26	2	37975162
Pubmed	Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.	PIEZO2 PIEZO1	5.37e-07	2	26	2	20813920
Pubmed	Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels.	PIEZO2 PIEZO1	5.37e-07	2	26	2	28636944
Pubmed	A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel.	PIEZO2 PIEZO1	5.37e-07	2	26	2	32142647
Pubmed	Expression analysis of P/Q-type Ca2+ channel alpha 1A subunit mRNA in olfactory mitral cell in N-type Ca2+ channel alpha 1B subunit gene-deficient mice.	CACNA1A CACNA1B	5.37e-07	2	26	2	15050706
Pubmed	Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception.	PIEZO2 PIEZO1	5.37e-07	2	26	2	34464353
Pubmed	Piezo channels: from structure to function.	PIEZO2 PIEZO1	5.37e-07	2	26	2	25037583
Pubmed	Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers.	CACNA1A CACNA1B	5.37e-07	2	26	2	23376566
Pubmed	Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.	GABRB1 CACNA1A CACNA1B	7.43e-07	24	26	3	22534482
Pubmed	Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.	GABRG1 ADRA2A PIEZO2	1.34e-06	29	26	3	37192624
Pubmed	Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and their correlation with brain biomechanical characteristics.	PIEZO2 PIEZO1	1.61e-06	3	26	2	38124148
Pubmed	Munc13-3 Is Required for the Developmental Localization of Ca2+ Channels to Active Zones and the Nanopositioning of Cav2.1 Near Release Sensors.	CACNA1A CACNA1B	1.61e-06	3	26	2	29466725
Pubmed	Molecular Sensors of Temperature, Pressure, and Pain with Special Focus on TRPV1, TRPM8, and PIEZO2 Ion Channels.	TRPM8 PIEZO2	1.61e-06	3	26	2	34825354
Pubmed	Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons.	PIEZO2 PIEZO1	1.61e-06	3	26	2	29521261
Pubmed	PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex.	PIEZO2 PIEZO1	1.61e-06	3	26	2	30361375
Pubmed	Piezo1, a mechanically activated ion channel, is required for vascular development in mice.	PIEZO2 PIEZO1	1.61e-06	3	26	2	24958852
Pubmed	Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting.	CACNA1A CACNA1B	1.61e-06	3	26	2	24394417
Pubmed	Molecular moieties masking Ca2+-dependent facilitation of voltage-gated Cav2.2 Ca2+ channels.	CACNA1A CACNA1B	1.61e-06	3	26	2	29208674
Pubmed	Labeling PIEZO2 activity in the peripheral nervous system.	PIEZO2 PIEZO1	1.61e-06	3	26	2	37321223
Pubmed	Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.	CACNA1A CACNA1B	1.61e-06	3	26	2	26507659
Pubmed	Expression of GABAA α2-, β1- and ε-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder.	GABRB1 GABRE	1.61e-06	3	26	2	24022508
Pubmed	Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice.	PIEZO2 PIEZO1	1.61e-06	3	26	2	30726728
Pubmed	Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth.	PIEZO2 PIEZO1	1.61e-06	3	26	2	35650194
Pubmed	Genetical genomic determinants of alcohol consumption in rats and humans.	GABRB1 GABRE ADRA2A CRHR2	2.61e-06	130	26	4	19874574
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	GABRE GABRG1 ADRA2A CRHR2 AGTR1	2.62e-06	300	26	5	19086053
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1A CACNA1B CACNA1E	3.07e-06	38	26	3	30786075
Pubmed	Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons.	CACNA1A CACNA1B	3.22e-06	4	26	2	26283199
Pubmed	Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.	PIEZO2 PIEZO1	3.22e-06	4	26	2	27893727
Pubmed	Interactions of Rabconnectin-3 with Cav2 calcium channels.	CACNA1A CACNA1B	3.22e-06	4	26	2	31253182
Pubmed	Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity.	PIEZO2 PIEZO1	3.22e-06	4	26	2	36563677
Pubmed	A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.	CACNA1A CACNA1B	3.22e-06	4	26	2	15728831
Pubmed	Piezo mechanosensory channels regulate centrosome integrity and mitotic entry.	PIEZO2 PIEZO1	3.22e-06	4	26	2	36574677
Pubmed	Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors.	GABRG1 CRHR2	3.22e-06	4	26	2	15001778
Pubmed	G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.	CACNA1A CACNA1B	3.22e-06	4	26	2	15953418
Pubmed	Sex differences in GABAergic gene expression occur in the anterior cingulate cortex in schizophrenia.	GABRB1 GABRE	3.22e-06	4	26	2	25660468
Pubmed	Impact of epsilon and theta subunits on pharmacological properties of alpha3beta1 GABAA receptors expressed in Xenopus oocytes.	GABRB1 GABRE	3.22e-06	4	26	2	16412217
Pubmed	Composition of the GABA(A) receptors of retinal dopaminergic neurons.	GABRE GABRG1	3.22e-06	4	26	2	10479684
Pubmed	The MAP1B-LC1/UBE2L3 complex catalyzes degradation of cell surface CaV2.2 channels.	CACNA1A CACNA1B	3.22e-06	4	26	2	25483588
Pubmed	Piezo1 and Piezo2 foster mechanical gating of K2P channels.	PIEZO2 PIEZO1	5.37e-06	5	26	2	34852225
Pubmed	Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.	GABRB1 GABRE	5.37e-06	5	26	2	9039914
Pubmed	Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.	CACNA1A CACNA1B	5.37e-06	5	26	2	16787652
Pubmed	Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity.	PIEZO2 PIEZO1	5.37e-06	5	26	2	36323321
Pubmed	A sequence-ready BAC contig of the GABAA receptor gene cluster Gabrg1-Gabra2-Gabrb1 on mouse chromosome 5.	GABRB1 GABRG1	8.05e-06	6	26	2	10447508
Pubmed	Complex trait analysis of the hippocampus: mapping and biometric analysis of two novel gene loci with specific effects on hippocampal structure in mice.	GABRB1 GABRG1	8.05e-06	6	26	2	11331379
Pubmed	A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes.	TRPM8 ADRA2A	8.05e-06	6	26	2	38442711
Pubmed	beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain.	CACNA1A CACNA1B	8.05e-06	6	26	2	10328888
Pubmed	Evolution of GABA(A) receptor diversity in the human genome.	GABRB1 GABRE	8.05e-06	6	26	2	10023064
Pubmed	Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact.	PIEZO2 PIEZO1	1.13e-05	7	26	2	38733989
Pubmed	theta, a novel gamma-aminobutyric acid type A receptor subunit.	GABRB1 GABRG1	1.13e-05	7	26	2	10449790
Pubmed	The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell.	PIEZO2 PIEZO1	1.50e-05	8	26	2	38228630
Pubmed	Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors.	PIEZO2 PIEZO1	1.50e-05	8	26	2	27161260
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1B CACNA1E	1.50e-05	8	26	2	28330839
Pubmed	Piezo1 and Piezo2 collectively regulate jawbone development.	PIEZO2 PIEZO1	1.50e-05	8	26	2	38619396
Pubmed	TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection.	PIEZO2 PIEZO1	1.50e-05	8	26	2	34112781
Pubmed	Quantitative trait locus for seizure susceptibility on mouse chromosome 5 confirmed with reciprocal congenic strains.	GABRB1 GABRG1	2.94e-05	11	26	2	17698926
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	GABRB1 GABRE GABRG1	3.04e-05	81	26	3	22723691
Pubmed	An Airway Protection Program Revealed by Sweeping Genetic Control of Vagal Afferents.	PIEZO2 CRHR2	4.17e-05	13	26	2	32259485
Pubmed	Do motor control genes contribute to interindividual variability in decreased movement in patients with pain?	GABRB1 ADRA2A	4.17e-05	13	26	2	17655760
Pubmed	The biochemical anatomy of cortical inhibitory synapses.	GABRB1 GABRG1	4.86e-05	14	26	2	22768092
Pubmed	Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.	CACNA1A CACNA1B	4.86e-05	14	26	2	21228161
Pubmed	DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.	ADRA2A PIEZO2	5.61e-05	15	26	2	37541195
Interaction	TMEM145 interactions	MCHR1 TMEM145	1.47e-05	5	25	2	int:TMEM145
Interaction	SSTR3 interactions	GABRB1 CACNA1A CACNA1E SLC44A1 TMEM145	1.06e-04	393	25	5	int:SSTR3
Interaction	MCHR1 interactions	MCHR1 TMEM145	1.14e-04	13	25	2	int:MCHR1
Interaction	NALCN interactions	CACNA1A CACNA1B	1.33e-04	14	25	2	int:NALCN
Interaction	SCN11A interactions	CACNA1A CACNA1B	1.54e-04	15	25	2	int:SCN11A
Interaction	FAM241B interactions	GABRE CCR3 C5AR1	1.84e-04	90	25	3	int:FAM241B
Interaction	SCN9A interactions	CACNA1A CACNA1B	3.06e-04	21	25	2	int:SCN9A
Interaction	CACNB2 interactions	CACNA1A CACNA1B	3.68e-04	23	25	2	int:CACNB2
Interaction	HHATL interactions	CACNA1A AGTR1	4.01e-04	24	25	2	int:HHATL
Interaction	CACNA1D interactions	CACNA1A CACNA1B	4.01e-04	24	25	2	int:CACNA1D
Interaction	CACNB1 interactions	CACNA1A CACNA1B	4.36e-04	25	25	2	int:CACNB1
Interaction	CACNB4 interactions	CACNA1A CACNA1B	4.36e-04	25	25	2	int:CACNB4
Interaction	SCN1A interactions	CACNA1A CACNA1B	5.88e-04	29	25	2	int:SCN1A
Cytoband	4p12	GABRB1 GABRG1	5.82e-05	20	26	2	4p12
Cytoband	Ensembl 112 genes in cytogenetic band chr4p12	GABRB1 GABRG1	9.94e-05	26	26	2	chr4p12
GeneFamily	Gamma-aminobutyric acid type A receptor subunits	GABRB1 GABRE GABRG1	1.29e-06	19	21	3	563
GeneFamily	Calcium voltage-gated channel subunits	CACNA1A CACNA1B CACNA1E	3.45e-06	26	21	3	253
GeneFamily	Solute carriers	SLC22A6 SLC35A3 SLC44A1 SLC16A14 SLC35B3	7.40e-05	395	21	5	752
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	CCR3 SLC44A1 C5AR1	1.02e-02	394	21	3	471
GeneFamily	EF-hand domain containing	CACNA1B CACNA1E	2.64e-02	219	21	2	863
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HSERT	GABRB1 CACNA1A GABRG1 CACNA1B CACNA1E SERINC1	3.33e-06	450	25	6	M39072
Coexpression	FAN_EMBRYONIC_CTX_EX_4_EXCITATORY_NEURON	GABRB1 CACNA1A CACNA1B CACNA1E	1.77e-05	166	25	4	M39026
Coexpression	GSE29615_CTRL_VS_LAIV_FLU_VACCINE_PBMC_UP	GABRE CCR3 ADRA2A PIEZO2	3.13e-05	192	25	4	M4923
Coexpression	SOGA_COLORECTAL_CANCER_MYC_DN	SLC35A3 SLC44A1 SLC35B3	4.20e-05	71	25	3	M45006
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HDA2	GABRB1 CACNA1A CACNA1B CACNA1E SERINC1	1.08e-04	513	25	5	M39069
Coexpression	DESCARTES_FETAL_HEART_SATB2_LRRC7_POSITIVE_CELLS	CACNA1A GABRG1 CACNA1E	1.76e-04	115	25	3	M40201
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HDA1	GABRB1 CACNA1B CACNA1E SERINC1 SLC16A14	1.98e-04	584	25	5	M39068
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Myeloid-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E C5AR1 TMEM145 AGTR1	2.28e-06	162	26	4	b502d6af6868425b5c919740e011330c0d3cf3b8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A CACNA1B CACNA1E DNAH3	2.57e-06	167	26	4	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1A CACNA1B CACNA1E TMEM145	2.69e-06	169	26	4	b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cnn1_(Mural.Rgs5Acta2.Cnn1)\|Striatum / BrainAtlas - Mouse McCarroll V32	SLC22A6 CRHR2 AGTR1	3.27e-05	107	26	3	d4807f008619dfd3e215d602df0d02b135b1ac37
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1\|Striatum / BrainAtlas - Mouse McCarroll V32	SLC22A6 CRHR2 AGTR1	3.27e-05	107	26	3	3f24de1afbfd070f9db11c9acd02b90e5eb2511d
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cnn1_(Mural.Rgs5Acta2.Cnn1)-\|Striatum / BrainAtlas - Mouse McCarroll V32	SLC22A6 CRHR2 AGTR1	3.27e-05	107	26	3	5907b9632c88d48f293c3c6d37b7ef831fbcdd86
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Nts\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GABRE GABRG1 CRHR2	5.45e-05	127	26	3	ace2944328529fa029ee56c7ad3b0f283511d3bb
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Esm1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GABRE GABRG1 CRHR2	5.97e-05	131	26	3	3cb4b272e28ee9bad6d874f64a7aae18352a6cfb
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crh_4930553C11Rik_\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PIEZO2 CRHR2 AGTR1	7.43e-05	141	26	3	ad9a25569c142fb68ded34aeba0cd9be8124ce56
ToppCell	COVID-19-Mast_cells-Transitioning_MDM\|COVID-19 / group, cell type (main and fine annotations)	TRPM8 CCR3 AGTR1	8.07e-05	145	26	3	5c5fed4620c4c312d1052b8acad910453f7e8fcc
ToppCell	COVID-19-kidney-Technical/muscle\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1A DNAH3 CST11	8.58e-05	148	26	3	0dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_2\|390C / Donor, Lineage, Cell class and subclass (all cells)	GABRE C5AR1 PIEZO1	9.84e-05	155	26	3	15bacd06cc2b02b13c85bb71c5b758e5ff613e80
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1A CACNA1B DNAH3	1.06e-04	159	26	3	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1A DNAH3 PIEZO2	1.14e-04	163	26	3	19c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1A CACNA1B TMEM145	1.16e-04	164	26	3	be49af6335f2505065cde2cb9800e4a5516811b1
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A PIEZO2 AGTR1	1.18e-04	165	26	3	e2aebb2fe197151e019371b8960f76f0c2386f08
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A PIEZO2 AGTR1	1.18e-04	165	26	3	b087771499aeb31cc4a338d2d0a9392a4ec1ac45
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A PIEZO2 AGTR1	1.18e-04	165	26	3	d8f8b088fd28a6b9dbd6b51bcaee42000e963321
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_SLITRK6\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG1 ADRA2A MCHR1	1.20e-04	166	26	3	a907d39ca5cf023de633fe5f2b28759b7af4eebc
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1A CACNA1B CACNA1E	1.23e-04	167	26	3	c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell	droplet-Lung-30m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l4\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GABRB1 ADRA2A C5AR1	1.23e-04	167	26	3	589c0acfeb4d70931b6726fb3331d85a54e74d56
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GABRG1 PIEZO2 AGTR1	1.23e-04	167	26	3	b4ef07117d14da3d5fbced949e4dfcb01c392295
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GABRG1 PIEZO2 AGTR1	1.23e-04	167	26	3	94fc7df7ca55cd722a8dbd153201a29891217473
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GABRG1 PIEZO2 AGTR1	1.23e-04	167	26	3	eff3723fe60755272eca237459165e436e919ece
ToppCell	severe_COVID-19-Neutrophil\|World / disease group, cell group and cell class (v2)	CACNA1E CCR3 C5AR1	1.29e-04	170	26	3	dfc807e0dd66179490a258ecbe8eb439e715799d
ToppCell	COVID-19-kidney-REN+Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1A PIEZO2 AGTR1	1.38e-04	174	26	3	8393f0b43c767839c1630bcb952d62b42efc788d
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Adult / Lineage, Cell type, age group and donor	CACNA1A CACNA1B PIEZO2	1.41e-04	175	26	3	4db1a3c284488b3f6de7568363f176d74e2a4587
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA1B CACNA1E ADRA2A	1.41e-04	175	26	3	8362a46f5804333baa84cd56d450bc147f372a7e
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A PIEZO2 AGTR1	1.41e-04	175	26	3	12f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231\|Adult / Lineage, Cell type, age group and donor	CACNA1A CACNA1B PIEZO2	1.41e-04	175	26	3	8d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA1B CACNA1E ADRA2A	1.41e-04	175	26	3	8b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCell	Monocytes-IFN-activated_Monocytes\|Monocytes / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	CACNA1A TRPM8 PIEZO2	1.43e-04	176	26	3	6a4b403ee3e4dc4f23fbd7a154011e41fd429a9e
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	ADRA2A PIEZO2 MCHR1	1.46e-04	177	26	3	cdfd2f0ee2f692271b1525e414b0f645cdadb1f6
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|356C / Donor, Lineage, Cell class and subclass (all cells)	ADRA2A PIEZO2 MCHR1	1.46e-04	177	26	3	db222faaecbe5600da39277243c4e7e764eb63c9
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GABRE PIEZO2 PIEZO1	1.48e-04	178	26	3	ad3de3e03a401dac64431a541899445262246347
ToppCell	ASK454-Endothelial-Lymphatic\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	CACNA1A DNAH3 PIEZO2	1.51e-04	179	26	3	fd84a79f76a01c0377dff5b20016b004d369f96f
ToppCell	3'_v3-bone_marrow-Hematopoietic_Erythro-Mega-Erythrocytic-Meg\|bone_marrow / Manually curated celltypes from each tissue	ADRA2A PIEZO2 AGTR1	1.53e-04	180	26	3	44ba37bead1ac39bce4d3eef00961063c50ced0d
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GABRE PIEZO2 PIEZO1	1.56e-04	181	26	3	e898ecb8d8f2eb2204225b7b0d665cadcd241139
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A PIEZO2 AGTR1	1.56e-04	181	26	3	a2058d658f07ab6f0a28d2622f3090b4cde6f763
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A PIEZO2 AGTR1	1.56e-04	181	26	3	526e858a848470b6d2d5248788004d9735ed3add
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GABRE PIEZO2 PIEZO1	1.58e-04	182	26	3	41b070085edba7a58b81c20aa4942d06f745acf8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GABRE PIEZO2 PIEZO1	1.58e-04	182	26	3	5e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GABRE PIEZO2 PIEZO1	1.58e-04	182	26	3	b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADRA2A CRHR2 AGTR1	1.61e-04	183	26	3	8de4b616a06be03e1cb6ae6a9ce6bf06485629d3
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B CACNA1E TMEM145	1.66e-04	185	26	3	110d5f02759c8235b14aea524ea47199696094ea
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GABRE PIEZO2 PIEZO1	1.69e-04	186	26	3	20340a5b5cc7f07386498a4ef937d6fbc9e347c4
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A PIEZO2 AGTR1	1.71e-04	187	26	3	ac8e092b37e042975e2ee057d3f7c6821e58e8b5
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A PIEZO2 AGTR1	1.71e-04	187	26	3	d591a3c216997663ab77710fed0d230ffc37e41a
ToppCell	droplet-Heart-nan-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRB1 ADRA2A AGTR1	1.71e-04	187	26	3	2591fe1552cd10925ad1d8d1f062a057ce6bdad9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A PIEZO2 AGTR1	1.71e-04	187	26	3	15d6e158562d7d85af3ceaf955439b379c8fce81
ToppCell	droplet-Heart-nan-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRB1 ADRA2A AGTR1	1.71e-04	187	26	3	59313a47a6012b2413d7d3673bb05fb7e49fd88f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A PIEZO2 AGTR1	1.71e-04	187	26	3	f62074b631fd45ad299c69d71b09267b04d656ee
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A PIEZO2 AGTR1	1.71e-04	187	26	3	d1dc8c9a2c2cd10c640257161a75e7730ec5bb41
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A PIEZO2 AGTR1	1.74e-04	188	26	3	32f22a4d8cb98fd8b8fa0fbf28ef9266d711d081
ToppCell	megakaryocytic-CD34+_Megakaryoblast\|World / Lineage and Cell class	ADRA2A SLC44A1 PIEZO2	1.79e-04	190	26	3	1d19b2bd55789bf13e1386332f46c605973d6f8e
ToppCell	facs-Brain_Non-Myeloid-Striatum\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC44A1 MCHR1 SERINC1	1.88e-04	193	26	3	d8ccfb780a75bdf9141f41fb29a076958601ebb4
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC44A1 MCHR1 SERINC1	1.91e-04	194	26	3	ba529c051f248d29f4222f4bc9801ba233859093
ToppCell	ILEUM-non-inflamed-(8)_Pericytes\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	GABRG1 ADRA2A AGTR1	1.97e-04	196	26	3	b98fe1519e420d8b03c66e164bf4544f3dbb2e44
ToppCell	facs-Brain_Non-Myeloid-Cortex\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRG1 SLC44A1 SERINC1	1.97e-04	196	26	3	256fe9bc0815f66a9afe11ba3507ef1372b52fd3
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GABRB1 GABRG1 AGTR1	1.97e-04	196	26	3	c16fbd23d9e117831b55ab3da5b08b22dd972432
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADRA2A CRHR2 AGTR1	2.03e-04	198	26	3	b7e900fc0a1b3fa5e47dcc36ce6b0c3ce6bf9739
ToppCell	18-Airway-Mesenchymal-Mesenchyme_RSPO2+\|Airway / Age, Tissue, Lineage and Cell class	SLC44A1 PIEZO2 AGTR1	2.06e-04	199	26	3	7ac35e8f45dcdc702422dabd8f3e4d03e2bf61af
ToppCell	18-Distal-Mesenchymal-Mesenchyme_RSPO2+\|Distal / Age, Tissue, Lineage and Cell class	SLC44A1 PIEZO2 AGTR1	2.06e-04	199	26	3	95403988caef322314f4ed15415ad1a9a987adc1
ToppCell	Tracheal-10x5prime-Stromal-Pericyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GABRG1 ADRA2A CRHR2	2.06e-04	199	26	3	cefc3b50f65e95da850e4720c7b44bf584073491
ToppCell	wk_15-18-Mesenchymal-Fibroblast-Alveolar_fibro\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SLC44A1 PIEZO2 AGTR1	2.06e-04	199	26	3	6bce8e65859a35cfea1c210f9c9765952d492ed2
ToppCell	Tracheal-10x5prime-Stromal-Pericyte-Muscle_pericyte_systemic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GABRG1 ADRA2A CRHR2	2.06e-04	199	26	3	aaa460c389cd6d38a13ba1a446f91a94f9573ad8
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal-Cortical_neuron\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	CACNA1A CACNA1E SERINC1	2.09e-04	200	26	3	5b3df61ff421846ef4cabf1bd5355534c8b95509
ToppCell	mLN-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	SLC44A1 C5AR1 SERINC1	2.09e-04	200	26	3	e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GABRB1 GABRG1 SLC22A6	2.09e-04	200	26	3	7a8160e6477708f22e48c609bf8f43f3715dcb03
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GABRB1 GABRG1 SLC22A6	2.09e-04	200	26	3	07d942803360e1a1e8e131d6e31c726dd0db1a0b
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GABRB1 GABRG1 SLC22A6	2.09e-04	200	26	3	d0812817ef99608994193787a62d39adeb2070ca
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GABRB1 GABRG1 SLC22A6	2.09e-04	200	26	3	cd54ddf1919c98e84b7e4aba85b374fc8b407206
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Grm1-Inhibitory_Neuron.Gad1Gad2_Sst.Grm1_(Interneuron,_OLM3_(CA1_enriched?))-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GABRE TRPM8	4.68e-04	55	26	2	10e98fc862d89141512bdebae1231ef1a82105b0
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Grm1-Inhibitory_Neuron.Gad1Gad2_Sst.Grm1_(Interneuron,_OLM3_(CA1_enriched?))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GABRE TRPM8	4.68e-04	55	26	2	a55d3edca2dd9ca7a703b2b3a5941b30b5f0a6df
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Grm1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GABRE TRPM8	4.68e-04	55	26	2	bac333ea3914a49376105dd977a0b8493b0d2001
Computational	Genes in the cancer module 146.	CCR3 ADRA2A C5AR1 AGTR1	7.11e-06	102	14	4	MODULE_146
Computational	Genes in the cancer module 288.	CCR3 C5AR1 AGTR1	1.33e-05	37	14	3	MODULE_288
Computational	Membranal receptors.	GABRE SLC22A6 ADRA2A C5AR1 CRHR2 AGTR1	2.59e-05	517	14	6	MODULE_64
Computational	Genes in the cancer module 173.	ADRA2A C5AR1	1.87e-04	16	14	2	MODULE_173
Computational	Genes in the cancer module 289.	CCR3 ADRA2A C5AR1	4.97e-04	124	14	3	MODULE_289
Computational	Genes in the cancer module 27.	GABRE ADRA2A C5AR1 AGTR1	9.00e-04	355	14	4	MODULE_27
Drug	gabapentin	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E ADRA2A	6.40e-10	169	26	7	CID000003446
Drug	morphine hydrochloride	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E CCR3 C5AR1 AGTR1	1.77e-09	481	26	9	CID000004253
Drug	AC 110	CACNA1A CACNA1B CACNA1E	5.28e-09	4	26	3	CID000022860
Drug	haloperidol	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E ADRA2A MCHR1	8.91e-09	394	26	8	CID000003559
Drug	eniluracil	CACNA1A CACNA1B CACNA1E MCHR1	2.30e-08	27	26	4	CID000043157
Drug	3,4-dihydroquinazoline	CACNA1A CACNA1B CACNA1E	2.64e-08	6	26	3	CID000583065
Drug	alpha-sialylcholesterol	CACNA1A CACNA1B CACNA1E	2.64e-08	6	26	3	CID000133976
Drug	riluzole	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E	3.71e-08	174	26	6	CID000005070
Drug	APMPA	CACNA1A CACNA1B CACNA1E	4.61e-08	7	26	3	CID000512300
Drug	3-aminopropylphosphinic acid	CACNA1A GABRG1 CACNA1B CACNA1E	4.70e-08	32	26	4	CID006335948
Drug	CGS 8216	GABRB1 GABRE GABRG1 MCHR1	5.34e-08	33	26	4	CID000104916
Drug	fluspirilene	CACNA1A CACNA1B CACNA1E ADRA2A	6.05e-08	34	26	4	CID000003396
Drug	baclofen	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E	6.45e-08	191	26	6	CID000002284
Drug	atropine sulfate	GABRB1 GABRE GABRG1 CACNA1B CACNA1E ADRA2A CRHR2	9.22e-08	347	26	7	CID000003661
Drug	cyclothiazide	GABRB1 GABRE CACNA1A GABRG1 SLC22A6	1.05e-07	103	26	5	CID000002910
Drug	AC1L1I54	CACNA1A CACNA1B CACNA1E MCHR1	1.31e-07	41	26	4	CID000004426
Drug	guanethidine	CACNA1A CACNA1B CACNA1E ADRA2A AGTR1	1.67e-07	113	26	5	CID000003518
Drug	leys	CACNA1A CACNA1B CACNA1E	2.17e-07	11	26	3	CID000484683
Drug	AC1L2VU3	CACNA1A CACNA1B CACNA1E	2.89e-07	12	26	3	CID000129572
Drug	tetradotoxin	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E ADRA2A	3.82e-07	428	26	7	CID000020382
Drug	etorphine	CACNA1A CACNA1B CACNA1E MCHR1	5.83e-07	59	26	4	CID000026721
Drug	butamben	CACNA1A CACNA1B CACNA1E	5.96e-07	15	26	3	CID000002482
Drug	pentasulfane	CACNA1A CACNA1B CACNA1E	7.33e-07	16	26	3	CID000448216
Drug	lindane	GABRB1 GABRE GABRG1 CACNA1B CACNA1E	7.78e-07	154	26	5	CID000000727
Drug	dopamine	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E ADRA2A AGTR1	8.61e-07	715	26	8	CID000000681
Drug	dihydroxyaflavinine	GABRB1 GABRE GABRG1	8.89e-07	17	26	3	CID000156857
Drug	AC1L2AC7	CACNA1A CACNA1B CACNA1E AGTR1	1.10e-06	69	26	4	CID000068733
Drug	halothane	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E	1.20e-06	314	26	6	CID000003562
Drug	norcepharadione B	CACNA1B CACNA1E	1.25e-06	2	26	2	CID000189168
Drug	aristolactam AII	CACNA1B CACNA1E	1.25e-06	2	26	2	CID000148657
Drug	alkosin	CACNA1B CACNA1E	1.25e-06	2	26	2	CID005488638
Drug	piperolactam A	CACNA1B CACNA1E	1.25e-06	2	26	2	CID003081016
Drug	N6-Me-dAdo	CACNA1A CACNA1B CACNA1E	1.27e-06	19	26	3	CID000168948
Drug	pranidipine	CACNA1A CACNA1B CACNA1E	1.27e-06	19	26	3	CID006436048
Drug	AC1L1KS5	CACNA1A CACNA1B CACNA1E C5AR1 CRHR2 AGTR1	1.71e-06	334	26	6	CID000005631
Drug	N-cyclopentyl-N-cyclobutylformamide	CACNA1A CACNA1B CACNA1E AGTR1	1.89e-06	79	26	4	CID005287890
Drug	LY320135	CACNA1A CACNA1B CACNA1E	2.31e-06	23	26	3	CID005311257
Drug	alpha-conotoxin SI	CACNA1A CACNA1B CACNA1E	2.31e-06	23	26	3	CID000163979
Drug	capsazepine	CACNA1A CACNA1B CACNA1E TRPM8	2.42e-06	84	26	4	CID002733484
Drug	methohexital	GABRB1 GABRE GABRG1	2.63e-06	24	26	3	CID000009034
Drug	brimonidine	CACNA1A CACNA1B CACNA1E ADRA2A	2.66e-06	86	26	4	CID000002435
Drug	hexachlorophene	CACNA1A CACNA1B CACNA1E MCHR1	3.19e-06	90	26	4	CID000003598
Drug	mAHP	CACNA1A CACNA1B CACNA1E	3.80e-06	27	26	3	CID000220531
Drug	manidipine	CACNA1A CACNA1B CACNA1E AGTR1	3.96e-06	95	26	4	CID000004008
Drug	pentobarbital	GABRB1 GABRE GABRG1 ADRA2A AGTR1	4.90e-06	224	26	5	CID000004737
Drug	3-isothujone	GABRB1 GABRE GABRG1	5.26e-06	30	26	3	CID000011027
Drug	AC1L1F6H	CACNA1A CACNA1B CACNA1E ADRA2A	6.13e-06	106	26	4	CID000003104
Drug	N-methyl-DL-aspartic acid	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E SLC35B3	6.45e-06	655	26	7	CID000004376
Drug	A61603	CACNA1A CACNA1B ADRA2A	7.05e-06	33	26	3	CID004038180
Drug	CNS 1145	CACNA1A CACNA1B CACNA1E	7.05e-06	33	26	3	CID000190902
Drug	AC1L2FYN	GABRB1 GABRE GABRG1	7.05e-06	33	26	3	CID000071333
Drug	IHC-64	CACNA1A CACNA1B CACNA1E	7.05e-06	33	26	3	CID000162753
Drug	methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate	GABRB1 GABRE	7.51e-06	4	26	2	ctd:C034818
Drug	glutamate	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E TRPM8 MCHR1	7.81e-06	962	26	8	CID000000611
Drug	flurazepam	GABRB1 GABRE GABRG1	8.44e-06	35	26	3	CID000003393
Drug	3-7a	CACNA1A CACNA1B CACNA1E	9.21e-06	36	26	3	CID011987860
Drug	CP-80	CACNA1A CACNA1B CACNA1E	9.21e-06	36	26	3	CID000452640
Drug	secobarbital	GABRB1 GABRE GABRG1	1.00e-05	37	26	3	CID000005193
Drug	8-cyclopentyltheophylline	CACNA1A CACNA1B CACNA1E	1.09e-05	38	26	3	CID000001917
Drug	DMCM	GABRB1 GABRE GABRG1	1.09e-05	38	26	3	CID000104999
Drug	3,4-diaminopyridine	CACNA1A CACNA1B CACNA1E	1.09e-05	38	26	3	CID000005918
Drug	zaleplon	GABRB1 GABRE GABRG1	1.18e-05	39	26	3	CID000005719
Drug	amlodipine	CACNA1A CACNA1B CACNA1E AGTR1	1.22e-05	126	26	4	CID000002162
Drug	almagel	CACNA1B CACNA1E	1.25e-05	5	26	2	CID003080942
Drug	S 8510	CACNA1A CACNA1B	1.25e-05	5	26	2	CID005488383
Drug	pimozide	CACNA1A CACNA1B CACNA1E ADRA2A	1.25e-05	127	26	4	CID000016362
Drug	furosemide	GABRB1 GABRE GABRG1 SLC22A6 AGTR1	1.26e-05	272	26	5	CID000003440
Drug	Gabrene	GABRB1 GABRE GABRG1	1.27e-05	40	26	3	CID005361323
Drug	gamma-aminobutyric acid	GABRB1 GABRE CACNA1A GABRG1 CACNA1B CACNA1E	1.27e-05	474	26	6	CID000000119
Drug	clozapine	GABRB1 GABRE GABRG1 ADRA2A MCHR1	1.30e-05	274	26	5	CID000002818
Drug	BMY 7378	CACNA1A CACNA1B ADRA2A	1.37e-05	41	26	3	CID000002419
Drug	gaboxadol	GABRB1 GABRE GABRG1	1.37e-05	41	26	3	CID000003448
Drug	5 beta-alphaxalone	GABRB1 GABRE GABRG1	1.47e-05	42	26	3	CID000068930
Drug	Fk 888	CACNA1A CACNA1B CACNA1E	1.47e-05	42	26	3	CID000107967
Drug	U46619	CACNA1A CACNA1B CACNA1E C5AR1 AGTR1	1.57e-05	285	26	5	CID000005618
Drug	zolpidem	GABRB1 GABRE GABRG1	1.58e-05	43	26	3	CID000005732
Drug	Calcium	CACNA1A CACNA1B CACNA1E TRPM8 ADRA2A AGTR1	1.59e-05	493	26	6	ctd:D002118
Drug	lorazepam	GABRB1 GABRE GABRG1	1.70e-05	44	26	3	CID000003958
Drug	heptachlor epoxide	GABRB1 GABRE GABRG1	1.94e-05	46	26	3	CID000013930
Drug	thymol	GABRB1 GABRE GABRG1	1.94e-05	46	26	3	CID000006989
Drug	nimodipine	CACNA1A GABRG1 CACNA1B CACNA1E	2.12e-05	145	26	4	CID000004497
Drug	nicardipine	CACNA1A CACNA1B CACNA1E AGTR1	2.12e-05	145	26	4	CID000004473
Drug	AC1Q5UBL	GABRB1 GABRE GABRG1 CACNA1B	2.17e-05	146	26	4	CID000005466
Drug	vigabatrin	GABRB1 GABRE GABRG1	2.35e-05	49	26	3	CID000005665
Drug	KW-3049	CACNA1A CACNA1B AGTR1	2.50e-05	50	26	3	CID000002324
Drug	procaine	CACNA1A GABRG1 CACNA1B CACNA1E	2.61e-05	153	26	4	CID000004914
Drug	procymidone	GABRB1 CACNA1A CACNA1B CRHR2	2.75e-05	155	26	4	ctd:C035988
Drug	BAPTA	CACNA1A GABRG1 CACNA1B CACNA1E AGTR1	2.91e-05	324	26	5	CID000104751
Drug	triazolam	GABRB1 GABRE GABRG1	3.15e-05	54	26	3	CID000005556
Drug	Cinildipine	CACNA1A CACNA1B CACNA1E	3.52e-05	56	26	3	CID000002752
Drug	nefiracetam	CACNA1A CACNA1B CACNA1E	3.52e-05	56	26	3	CID000071157
Drug	felodipine	CACNA1A CACNA1B CACNA1E AGTR1	3.86e-05	169	26	4	CID000003333
Drug	flunitrazepam	GABRB1 GABRE GABRG1	4.12e-05	59	26	3	CID000003380
Drug	5 beta-pregnanediol	GABRB1 GABRE GABRG1	4.33e-05	60	26	3	CID000012547
Drug	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	CACNA1E TRPM8 ADRA2A	4.33e-05	60	26	3	ctd:C060229
Drug	nilvadipine	CACNA1A CACNA1B CACNA1E	4.33e-05	60	26	3	CID000004494
Drug	GTP[S]	CACNA1A CACNA1B CACNA1E C5AR1 MCHR1 AGTR1	4.41e-05	591	26	6	CID000001764
Drug	IAA-94	CACNA1A CACNA1B CACNA1E	4.55e-05	61	26	3	CID000003667
Drug	gamma-Aminobutyric Acid	GABRB1 GABRE GABRG1	4.78e-05	62	26	3	ctd:D005680
Drug	EGTA-AM	CACNA1A CACNA1B CACNA1E	4.78e-05	62	26	3	CID000121907
Disease	familial hemiplegic migraine 1 (implicated_via_orthology)	CACNA1A CACNA1B CACNA1E	5.37e-10	3	25	3	DOID:0111181 (implicated_via_orthology)
Disease	migraine (implicated_via_orthology)	CACNA1A CACNA1B CACNA1E	2.15e-09	4	25	3	DOID:6364 (implicated_via_orthology)
Disease	hereditary ataxia (implicated_via_orthology)	CACNA1A CACNA1B CACNA1E	1.88e-08	7	25	3	DOID:0050951 (implicated_via_orthology)
Disease	Bipolar Disorder	GABRB1 CACNA1A GABRG1 CACNA1B MCHR1 CRHR2	2.36e-06	477	25	6	C0005586
Disease	rhinitis (is_marker_for)	CCR3 C5AR1 CRHR2	7.96e-06	46	25	3	DOID:4483 (is_marker_for)
Disease	epilepsy (implicated_via_orthology)	CACNA1A CACNA1B CACNA1E	3.48e-04	163	25	3	DOID:1826 (implicated_via_orthology)
Disease	Mood Disorders	ADRA2A MCHR1 CRHR2	3.80e-04	168	25	3	C0525045
Disease	asthma (implicated_via_orthology)	CCR3 AGTR1	4.03e-04	35	25	2	DOID:2841 (implicated_via_orthology)
Disease	Hypertensive disease	ADRA2A CRHR2 AGTR1	5.44e-04	190	25	3	C0020538
Disease	multiple sclerosis (is_marker_for)	CACNA1B CCR3	7.91e-04	49	25	2	DOID:2377 (is_marker_for)
Disease	Mental Depression	ADRA2A MCHR1 CRHR2	1.26e-03	254	25	3	C0011570
Disease	Alcoholic Intoxication, Chronic	GABRB1 GABRG1 ADRA2A	1.47e-03	268	25	3	C0001973
Disease	juvenile idiopathic arthritis	CCR3 NPHP4	1.79e-03	74	25	2	EFO_0002609
Disease	Depressive disorder	ADRA2A MCHR1 CRHR2	1.82e-03	289	25	3	C0011581
Disease	beverage consumption measurement	GABRB1 MCHR1	2.25e-03	83	25	2	EFO_0010088
Disease	Dystonia	CACNA1A CACNA1E	2.41e-03	86	25	2	C0013421

Protein segments in the cluster

Peptide	Gene	Start	Entry
VVYFVVFPFFFVNIF	CACNA1A	1491	O00555
YFVVFPFFFVNIFVA	CACNA1E	1406	Q15878
VLFFFFSWIPHQIFT	AGTR1	246	P30556
AVVASFFIFWLPYQV	C5AR1	246	P21730
FFSVFAVPWFEQYKI	CST11	116	Q9H112
YVVYFVVFPFFFVNI	CACNA1B	1396	Q00975
FFFIFYSQIWILYPI	OR52A4P	261	A6NMU1
FNYFVVTNFFWMFVE	CRHR2	191	Q13324
FFPITFSLFNVVYWL	GABRB1	456	P18505
VVFPVTFFFFNVLYW	GABRE	486	P78334
SWPKTVYFTFQFYRF	NPHP4	661	O75161
AVFFIFWTPYNVAIL	CCR3	246	P51677
PVVFWISGFYFTQSF	DNAH3	3961	Q8TD57
FFPTAFALFNLVYWV	GABRG1	446	Q8N1C3
WFTLYQFFLAFALPF	MCHR1	276	Q99705
FQPFWTFFALVLFWV	SLC44A1	336	Q8WWI5
APFFAFFIYSWFFIE	SLC22A6	256	Q4U2R8
FWALFAYSSFVIPFI	SLC16A14	321	Q7RTX9
SFIFFAKPFTFQYVW	SLC35B3	341	Q9H1N7
FFIPEGTFTTVWFYV	SERINC1	141	Q9NRX5
GVFVVCWFPFFFTYT	ADRA2A	396	P08913
IVVKYFFQFGFFPWN	PIEZO2	1976	Q9H5I5
YFWLQDFVPTSVFFL	SLC35A3	286	Q9Y2D2
VVVKYLFQFGFFPWN	PIEZO1	1741	Q92508
YYVAFFTSPFVVFSW	TRPM8	726	Q7Z2W7
FTSPFVVFSWNVVFY	TRPM8	731	Q7Z2W7
PFYVPFFAAYTLWFF	TMEM145	346	Q8NBT3