Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN4A SCN8A SCN9A	2.87e-05	26	46	3	GO:0005248
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC6A7 SLC6A13 SCN4A SCN8A SCN9A	4.48e-05	171	46	5	GO:0015081
GeneOntologyMolecularFunction	neuroligin family protein binding	NRXN1 NRXN2	5.17e-05	5	46	2	GO:0097109
GeneOntologyMolecularFunction	sodium channel activity	SCN4A SCN8A SCN9A	2.34e-04	52	46	3	GO:0005272
GeneOntologyMolecularFunction	sodium ion binding	SCN8A SCN9A	4.64e-04	14	46	2	GO:0031402
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC6A7 SLC6A13 SCN4A MCOLN2 SCN8A SCN9A	6.57e-04	465	46	6	GO:0046873
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC6A7 SLC6A13 ANO10 SCN4A MCOLN2 SCN8A SCN9A	7.54e-04	664	46	7	GO:0008324
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR2B11 OR2K2 OR5T1 UTS2R HTR4 NRXN1 ITGAL NRXN2 OR9G4 OR5AL1	8.50e-04	1353	46	10	GO:0004888
GeneOntologyMolecularFunction	monoatomic cation channel activity	ANO10 SCN4A MCOLN2 SCN8A SCN9A	1.12e-03	343	46	5	GO:0005261
GeneOntologyMolecularFunction	amino acid:sodium symporter activity	SLC6A7 SLC6A13	1.27e-03	23	46	2	GO:0005283
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC6A7 SLC6A13 ANO10 SCN4A MCOLN2 SCN8A SCN9A	1.63e-03	758	46	7	GO:0015318
GeneOntologyMolecularFunction	alkali metal ion binding	SCN8A SCN9A	1.63e-03	26	46	2	GO:0031420
GeneOntologyMolecularFunction	amino acid transmembrane transporter activity	SLC6A7 SLC6A13 SLC66A1	1.82e-03	105	46	3	GO:0015171
GeneOntologyMolecularFunction	amino acid:monoatomic cation symporter activity	SLC6A7 SLC6A13	2.03e-03	29	46	2	GO:0005416
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC6A7 SLC6A13 ANO10 SCN4A MCOLN2 SCN8A SCN9A	2.10e-03	793	46	7	GO:0015075
GeneOntologyMolecularFunction	organic acid:sodium symporter activity	SLC6A7 SLC6A13	2.94e-03	35	46	2	GO:0005343
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC6A7 SLC6A13 SCN4A MCOLN2 SCN8A SCN9A	3.01e-03	627	46	6	GO:0022890
GeneOntologyMolecularFunction	olfactory receptor activity	OR2B11 OR2K2 OR5T1 OR9G4 OR5AL1	3.03e-03	431	46	5	GO:0004984
GeneOntologyMolecularFunction	odorant binding	OR5T1 OR9G4 OR5AL1	3.12e-03	127	46	3	GO:0005549
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2B11 OR2K2 OR5T1 UTS2R HTR4 OR9G4 OR5AL1	3.85e-03	884	46	7	GO:0004930
GeneOntologyMolecularFunction	monoatomic ion channel activity	ANO10 SCN4A MCOLN2 SCN8A SCN9A	3.96e-03	459	46	5	GO:0005216
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC6A7 SLC6A13 ANO10 SLC66A1 SCN4A MCOLN2 SCN8A SCN9A	5.09e-03	1180	46	8	GO:0022857
GeneOntologyMolecularFunction	calcium channel regulator activity	NRXN1 NRXN2	6.88e-03	54	46	2	GO:0005246
GeneOntologyMolecularFunction	channel activity	ANO10 SCN4A MCOLN2 SCN8A SCN9A	6.95e-03	525	46	5	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	ANO10 SCN4A MCOLN2 SCN8A SCN9A	7.01e-03	526	46	5	GO:0022803
GeneOntologyBiologicalProcess	neuroligin clustering involved in postsynaptic membrane assembly	NRXN1 NRXN2	2.91e-05	4	46	2	GO:0097118
GeneOntologyBiologicalProcess	gephyrin clustering involved in postsynaptic density assembly	NRXN1 NRXN2	4.85e-05	5	46	2	GO:0097116
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN4A SCN8A SCN9A	7.04e-05	36	46	3	GO:0086010
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	SLC6A7 SLC6A13 SCN4A SCN8A SCN9A	9.73e-05	208	46	5	GO:0035725
GeneOntologyBiologicalProcess	vocal learning	NRXN1 NRXN2	1.01e-04	7	46	2	GO:0042297
GeneOntologyBiologicalProcess	imitative learning	NRXN1 NRXN2	1.01e-04	7	46	2	GO:0098596
GeneOntologyBiologicalProcess	observational learning	NRXN1 NRXN2	1.73e-04	9	46	2	GO:0098597
GeneOntologyBiologicalProcess	postsynaptic density protein 95 clustering	NRXN1 NRXN2	2.64e-04	11	46	2	GO:0097119
GeneOntologyBiologicalProcess	postsynaptic membrane assembly	NRXN1 NRXN2	2.64e-04	11	46	2	GO:0097104
GeneOntologyBiologicalProcess	learned vocalization behavior or vocal learning	NRXN1 NRXN2	2.64e-04	11	46	2	GO:0098598
GeneOntologyBiologicalProcess	sodium ion transport	SLC6A7 SLC6A13 SCN4A SCN8A SCN9A	3.56e-04	275	46	5	GO:0006814
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	SCN4A SCN8A SCN9A	3.58e-04	62	46	3	GO:0086002
GeneOntologyBiologicalProcess	neuronal action potential	SCN4A SCN8A SCN9A	3.75e-04	63	46	3	GO:0019228
GeneOntologyBiologicalProcess	auditory behavior	NRXN1 NRXN2	4.35e-04	14	46	2	GO:0031223
GeneOntologyBiologicalProcess	neuron cell-cell adhesion	NRXN1 NRXN2	5.72e-04	16	46	2	GO:0007158
GeneOntologyBiologicalProcess	mechanosensory behavior	NRXN1 NRXN2	6.48e-04	17	46	2	GO:0007638
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN4A SCN8A SCN9A	7.09e-06	17	47	3	GO:0001518
GeneOntologyCellularComponent	sodium channel complex	SCN4A SCN8A SCN9A	3.74e-05	29	47	3	GO:0034706
GeneOntologyCellularComponent	presynaptic active zone membrane	NRXN1 NRXN2 SCN8A	7.20e-04	78	47	3	GO:0048787
Domain	Na_channel_asu	SCN4A SCN8A SCN9A	1.17e-06	10	41	3	IPR001696
Domain	Na_trans_assoc	SCN4A SCN8A SCN9A	1.17e-06	10	41	3	IPR010526
Domain	Na_trans_assoc	SCN4A SCN8A SCN9A	1.17e-06	10	41	3	PF06512
Domain	Na_trans_cytopl	SCN8A SCN9A	7.01e-05	6	41	2	PF11933
Domain	Na_trans_cytopl	SCN8A SCN9A	7.01e-05	6	41	2	IPR024583
Domain	Syndecan	NRXN1 NRXN2	9.81e-05	7	41	2	PF01034
Domain	Syndecan/Neurexin_dom	NRXN1 NRXN2	9.81e-05	7	41	2	IPR027789
Domain	Ion_trans_dom	SCN4A MCOLN2 SCN8A SCN9A	1.12e-04	114	41	4	IPR005821
Domain	Ion_trans	SCN4A MCOLN2 SCN8A SCN9A	1.12e-04	114	41	4	PF00520
Domain	Channel_four-helix_dom	SCN4A SCN8A SCN9A	2.65e-04	57	41	3	IPR027359
Domain	-	SCN4A SCN8A SCN9A	2.65e-04	57	41	3	1.20.120.350
Domain	Neurexin-like	NRXN1 NRXN2	4.21e-04	14	41	2	IPR003585
Domain	4.1m	NRXN1 NRXN2	4.21e-04	14	41	2	SM00294
Domain	IQ	SCN4A SCN8A SCN9A	5.06e-04	71	41	3	PF00612
Domain	Disintegrin_CS	ADAM19 ADAM18	5.53e-04	16	41	2	IPR018358
Domain	ADAM_CR	ADAM19 ADAM18	7.04e-04	18	41	2	PF08516
Domain	NA_NEUROTRAN_SYMP_2	SLC6A7 SLC6A13	7.04e-04	18	41	2	PS00754
Domain	IQ	SCN4A SCN8A SCN9A	7.44e-04	81	41	3	SM00015
Domain	NA_NEUROTRAN_SYMP_3	SLC6A7 SLC6A13	7.85e-04	19	41	2	PS50267
Domain	SNF	SLC6A7 SLC6A13	7.85e-04	19	41	2	PF00209
Domain	Na/ntran_symport	SLC6A7 SLC6A13	7.85e-04	19	41	2	IPR000175
Domain	NA_NEUROTRAN_SYMP_1	SLC6A7 SLC6A13	7.85e-04	19	41	2	PS00610
Domain	-	ADAM19 ADAM18	8.71e-04	20	41	2	4.10.70.10
Domain	DISIN	ADAM19 ADAM18	9.62e-04	21	41	2	SM00050
Domain	Disintegrin	ADAM19 ADAM18	9.62e-04	21	41	2	PF00200
Domain	IQ_motif_EF-hand-BS	SCN4A SCN8A SCN9A	1.01e-03	90	41	3	IPR000048
Domain	IQ	SCN4A SCN8A SCN9A	1.11e-03	93	41	3	PS50096
Domain	ADAM_Cys-rich	ADAM19 ADAM18	1.59e-03	27	41	2	IPR006586
Domain	ACR	ADAM19 ADAM18	1.59e-03	27	41	2	SM00608
Domain	EGF_3	ADAM19 NRXN1 NRXN2 ADAM18	1.72e-03	235	41	4	PS50026
Domain	EGF-like_dom	ADAM19 NRXN1 NRXN2 ADAM18	2.12e-03	249	41	4	IPR000742
Domain	EGF_1	ADAM19 NRXN1 NRXN2 ADAM18	2.31e-03	255	41	4	PS00022
Domain	EGF-like_CS	ADAM19 NRXN1 NRXN2 ADAM18	2.51e-03	261	41	4	IPR013032
Domain	EGF_2	ADAM19 NRXN1 NRXN2 ADAM18	2.66e-03	265	41	4	PS01186
Domain	LAM_G_DOMAIN	NRXN1 NRXN2	3.14e-03	38	41	2	PS50025
Domain	GPCR_Rhodpsn_7TM	OR2B11 OR2K2 OR5T1 UTS2R HTR4 OR9G4	3.21e-03	670	41	6	IPR017452
Domain	Peptidase_M12B_N	ADAM19 ADAM18	3.31e-03	39	41	2	IPR002870
Domain	Pep_M12B_propep	ADAM19 ADAM18	3.31e-03	39	41	2	PF01562
Domain	7tm_1	OR2B11 OR2K2 OR5T1 UTS2R HTR4 OR9G4	3.38e-03	677	41	6	PF00001
Domain	DISINTEGRIN_1	ADAM19 ADAM18	3.48e-03	40	41	2	PS00427
Domain	Laminin_G_2	NRXN1 NRXN2	3.48e-03	40	41	2	PF02210
Domain	ADAM_MEPRO	ADAM19 ADAM18	3.48e-03	40	41	2	PS50215
Domain	DISINTEGRIN_2	ADAM19 ADAM18	3.48e-03	40	41	2	PS50214
Domain	Reprolysin	ADAM19 ADAM18	3.48e-03	40	41	2	PF01421
Domain	Peptidase_M12B	ADAM19 ADAM18	3.48e-03	40	41	2	IPR001590
Domain	G_PROTEIN_RECEP_F1_1	OR2B11 OR2K2 OR5T1 UTS2R HTR4 OR9G4	3.58e-03	685	41	6	PS00237
Domain	Disintegrin_dom	ADAM19 ADAM18	3.65e-03	41	41	2	IPR001762
Domain	G_PROTEIN_RECEP_F1_2	OR2B11 OR2K2 OR5T1 UTS2R HTR4 OR9G4	3.74e-03	691	41	6	PS50262
Domain	GPCR_Rhodpsn	OR2B11 OR2K2 OR5T1 UTS2R HTR4 OR9G4	3.77e-03	692	41	6	IPR000276
Domain	LamG	NRXN1 NRXN2	4.20e-03	44	41	2	SM00282
Domain	Laminin_G	NRXN1 NRXN2	7.19e-03	58	41	2	IPR001791
Domain	EGF_extracell	ADAM19 ADAM18	7.68e-03	60	41	2	IPR013111
Domain	EGF_2	ADAM19 ADAM18	7.68e-03	60	41	2	PF07974
Domain	Olfact_rcpt	OR2B11 OR2K2 OR5T1 OR9G4	1.06e-02	393	41	4	IPR000725
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN4A SCN8A SCN9A	4.57e-05	31	32	3	M877
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	SCN4A SCN8A SCN9A	5.04e-05	32	32	3	M27455
Pathway	WP_ADHD_AND_AUTISM_ASD_PATHWAYS	HTR4 NRXN1 NRXN2 SCN4A SCN8A SCN9A	1.53e-04	367	32	6	M48346
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN4A SCN8A SCN9A	1.93e-07	9	47	3	16382098
Pubmed	State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine.	SCN4A SCN9A	1.79e-06	2	47	2	18079277
Pubmed	Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin.	NRXN1 NRXN2	1.79e-06	2	47	2	1621094
Pubmed	Mutations in NRXN1 and NRXN2 in a patient with early-onset epileptic encephalopathy and respiratory depression.	NRXN1 NRXN2	1.79e-06	2	47	2	30709877
Pubmed	Sodium channel slow inactivation interferes with open channel block.	SCN8A SCN9A	1.79e-06	2	47	2	27174182
Pubmed	Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.	NRXN1 NRXN2	1.79e-06	2	47	2	26595880
Pubmed	ADAM19 and HTR4 variants and pulmonary function: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.	ADAM19 HTR4	1.79e-06	2	47	2	24951661
Pubmed	Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior.	NRXN1 NRXN2	5.36e-06	3	47	2	34133920
Pubmed	Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca2+ Influx.	NRXN1 NRXN2	5.36e-06	3	47	2	38891114
Pubmed	Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing.	NRXN1 NRXN2	5.36e-06	3	47	2	12036300
Pubmed	β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling.	NRXN1 NRXN2	5.36e-06	3	47	2	26213384
Pubmed	Neurexin gene family variants as risk factors for autism spectrum disorder.	NRXN1 NRXN2	5.36e-06	3	47	2	29045040
Pubmed	Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses.	NRXN1 NRXN2	5.36e-06	3	47	2	31005376
Pubmed	Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization.	NRXN1 NRXN2	5.36e-06	3	47	2	38571813
Pubmed	Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons.	NRXN1 NRXN2	5.36e-06	3	47	2	35173587
Pubmed	Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia.	NRXN1 NRXN2	5.36e-06	3	47	2	21424692
Pubmed	The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice.	NRXN1 NRXN2	5.36e-06	3	47	2	30858964
Pubmed	Neurexins are differentially expressed in the embryonic nervous system of mice.	NRXN1 NRXN2	5.36e-06	3	47	2	7722633
Pubmed	Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.	NRXN1 NRXN2	5.36e-06	3	47	2	26446217
Pubmed	Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex.	NRXN1 NRXN2	5.36e-06	3	47	2	28013231
Pubmed	Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.	NRXN1 NRXN2	5.36e-06	3	47	2	11944992
Pubmed	alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction.	NRXN1 NRXN2	5.36e-06	3	47	2	16406382
Pubmed	Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.	NRXN1 NRXN2	5.36e-06	3	47	2	33058888
Pubmed	Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.	NRXN1 NRXN2	5.36e-06	3	47	2	17035546
Pubmed	Neurexins: three genes and 1001 products.	NRXN1 NRXN2	5.36e-06	3	47	2	9448462
Pubmed	Deletion of α-neurexin II results in autism-related behaviors in mice.	NRXN1 NRXN2	5.36e-06	3	47	2	25423136
Pubmed	Ketamine Restores Thalamic-Prefrontal Cortex Functional Connectivity in a Mouse Model of Neurodevelopmental Disorder-Associated 2p16.3 Deletion.	NRXN1 NRXN2	5.36e-06	3	47	2	31812984
Pubmed	Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.	SCN4A SCN9A	5.36e-06	3	47	2	20038812
Pubmed	Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia.	SCN8A SCN9A	5.36e-06	3	47	2	15302875
Pubmed	Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins.	NRXN1 NRXN2	1.07e-05	4	47	2	14983056
Pubmed	CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.	NRXN1 NRXN2	1.07e-05	4	47	2	8786425
Pubmed	Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation.	NRXN1 NRXN2	1.07e-05	4	47	2	17347997
Pubmed	Neurexins cluster Ca2+ channels within the presynaptic active zone.	NRXN1 NRXN2	1.07e-05	4	47	2	32134527
Pubmed	Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism.	NRXN1 NRXN2	1.07e-05	4	47	2	32706374
Pubmed	RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1.	ITGAL RFX1	1.07e-05	4	47	2	21192791
Pubmed	Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins.	NRXN1 NRXN2	1.07e-05	4	47	2	35385735
Pubmed	Neurexins regulate presynaptic GABAB-receptors at central synapses.	NRXN1 NRXN2	1.07e-05	4	47	2	33888718
Pubmed	Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins.	NRXN1 NRXN2	1.78e-05	5	47	2	28472659
Pubmed	Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions.	NRXN1 NRXN2	1.78e-05	5	47	2	36709330
Pubmed	Pro-apoptotic function of checkpoint kinase-2 in syncytia elicited by the HIV-1 envelope.	CHEK2 TOPBP1	1.78e-05	5	47	2	19177012
Pubmed	Neuroligins and neurexins link synaptic function to cognitive disease.	NRXN1 NRXN2	1.78e-05	5	47	2	18923512
Pubmed	Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum.	NRXN1 NRXN2	1.78e-05	5	47	2	20537373
Pubmed	Early development of electrical excitability in the mouse enteric nervous system.	SCN8A SCN9A	1.78e-05	5	47	2	22875929
Pubmed	Do checkpoint kinases contribute to HIV-1-mediated apoptosis?	CHEK2 TOPBP1	1.78e-05	5	47	2	19164952
Pubmed	Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration.	NRXN1 NRXN2	1.78e-05	5	47	2	9223334
Pubmed	Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.	SCN4A SCN8A	1.78e-05	5	47	2	17724025
Pubmed	Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.	SCN8A SCN9A	2.67e-05	6	47	2	16029194
Pubmed	Structures, alternative splicing, and neurexin binding of multiple neuroligins.	NRXN1 NRXN2	2.67e-05	6	47	2	8576240
Pubmed	Presynaptic α2δ-2 Calcium Channel Subunits Regulate Postsynaptic GABAA Receptor Abundance and Axonal Wiring.	NRXN1 NRXN2	2.67e-05	6	47	2	30683685
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN8A SCN9A	2.67e-05	6	47	2	23652591
Pubmed	Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.	NRXN1 NRXN2	2.67e-05	6	47	2	12827191
Pubmed	Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.	NRXN1 NRXN2	4.98e-05	8	47	2	30871858
Pubmed	Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit.	NRXN1 NRXN2	4.98e-05	8	47	2	37591863
Pubmed	Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons.	NRXN1 NRXN2	6.40e-05	9	47	2	21356198
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN4A SCN8A	6.40e-05	9	47	2	15746173
Pubmed	PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.	NRXN1 NRXN2	6.40e-05	9	47	2	9707552
Pubmed	Molecular self-avoidance in synaptic neurexin complexes.	NRXN1 NRXN2	6.40e-05	9	47	2	34919427
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2B11 OR2K2 OR5T1 OR9G4 OR5AL1	9.50e-05	340	47	5	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2B11 OR2K2 OR5T1 OR9G4 OR5AL1	9.50e-05	340	47	5	11802173
Pubmed	SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.	NRXN1 NRXN2	9.75e-05	11	47	2	32973045
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2B11 OR2K2 OR5T1 OR9G4 OR5AL1	9.89e-05	343	47	5	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2B11 OR2K2 OR5T1 OR9G4 OR5AL1	1.03e-04	346	47	5	14611657
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN8A SCN9A	1.38e-04	13	47	2	15123669
Pubmed	The contribution of rare and common variants in 30 genes to risk nicotine dependence.	NRXN1 NRXN2	1.61e-04	14	47	2	25450229
Pubmed	Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.	ADAM19 HTR4	2.12e-04	16	47	2	20010835
Pubmed	The repertoire of solute carriers of family 6: identification of new human and rodent genes.	SLC6A7 SLC6A13	3.69e-04	21	47	2	16125675
Pubmed	Cbln1 regulates axon growth and guidance in multiple neural regions.	NRXN1 NRXN2	4.06e-04	22	47	2	36395107
Pubmed	Exploring the link between MORF4L1 and risk of breast cancer.	CHEK2 TOPBP1	4.84e-04	24	47	2	21466675
Pubmed	Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors.	CHEK2 TOPBP1	4.84e-04	24	47	2	22522401
Pubmed	ATR maintains select progenitors during nervous system development.	CHEK2 TOPBP1	5.26e-04	25	47	2	22266795
Pubmed	Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development.	NRXN1 NRXN2	6.61e-04	28	47	2	38324473
Pubmed	Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A.	HTR4 SCN8A	6.61e-04	28	47	2	19352218
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	SLC6A13 HTR4 NRXN1 NRXN2	7.23e-04	300	47	4	19086053
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	TOPBP1 NRXN1 NRXN2	7.34e-04	130	47	3	12421765
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	SCN4A SCN8A SCN9A	8.91e-04	139	47	3	16985003
Pubmed	Defining the membrane proteome of NK cells.	GOLIM4 NRM ANO10 IPO9 ITGAL CCDC47 DDX18	9.20e-04	1168	47	7	19946888
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	GOLIM4 NRM NAA25 ANO10 IPO9 RFX1 NUP160	1.09e-03	1203	47	7	29180619
Cytoband	Ensembl 112 genes in cytogenetic band chr17q23	RNFT1 CCDC47 SCN4A	2.60e-04	120	47	3	chr17q23
Cytoband	17q23.3	CCDC47 SCN4A	4.38e-04	30	47	2	17q23.3
Cytoband	11q12.1	OR5T1 OR9G4 OR5AL1	6.13e-04	161	47	3	11q12.1
Cytoband	Ensembl 112 genes in cytogenetic band chr5q32	SLC6A7 HTR4	3.08e-03	80	47	2	chr5q32
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN4A SCN8A SCN9A	4.20e-07	9	32	3	1203
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ADAM19 ADAM18	1.04e-03	27	32	2	47
GeneFamily	Olfactory receptors, family 5	OR5T1 OR5AL1	1.67e-02	112	32	2	152
GeneFamily	Olfactory receptors, family 2	OR2B11 OR2K2	1.70e-02	113	32	2	149
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_7DY_DN	RNFT1 PCSK7 TUT4 ADAM19 ITGAL RFX1 ZMIZ2 MCOLN2	1.30e-05	634	46	8	M40866
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-dendritic_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC6A7 NAA25 ADAM19 NRXN2 MCOLN2	1.07e-06	177	46	5	aa56129d2d5a73a10e33b7162233a4d9337ee535
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs-Migratory_DCs_L.1.2.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC6A7 NAA25 ADAM19 NRXN2 MCOLN2	1.07e-06	177	46	5	d78a6003ce2d15d7771ae385de252eec7e3c3eea
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC6A7 NAA25 ADAM19 NRXN2 MCOLN2	1.07e-06	177	46	5	70ca5b6fde2e38af1eb88a7d6e8746edba298191
ToppCell	COPD-Myeloid-DC_Langerhans\|COPD / Disease state, Lineage and Cell class	ADAM19 DEXI MCOLN2 SCN9A	2.13e-05	158	46	4	71af1319eec34bf7bc9361ec9ef720c280ce97d1
ToppCell	COPD-Myeloid-DC_Langerhans\|World / Disease state, Lineage and Cell class	ADAM19 DEXI MCOLN2 SCN9A	2.24e-05	160	46	4	1b73a14ad6546d9f2812c19081278a79260abeae
ToppCell	Children_(3_yrs)-Immune-dendritic_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAM19 DEXI MCOLN2 SCN9A	2.35e-05	162	46	4	86a0b9dabd150dc993bfc0f3344804de7f8e4042
ToppCell	Adult-Immune-dendritic_cell\|Adult / Lineage, Cell type, age group and donor	ADAM19 NRXN2 SCN4A MCOLN2	2.52e-05	165	46	4	073f52698dac1fe4edd7410865f81b30e1c7196a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NRM ADAM19 ITGAL MCOLN2	2.58e-05	166	46	4	63dc58864268b4e7779e4c45155022556fc634f9
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	TUT4 ADAM19 IPO9 MCOLN2	3.11e-05	174	46	4	2274648b80dd74f3c948a779bba3391095964c34
ToppCell	Adult-Immune-dendritic_cell-D175\|Adult / Lineage, Cell type, age group and donor	ADAM19 NRXN2 SCN4A MCOLN2	3.25e-05	176	46	4	1f0f1f953e6d61119f342de0d980aa1287511dba
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRM SHISAL1 MAN1C1 ATCAY	3.62e-05	181	46	4	4e81ec1580e9acb22c32c465eb46f83d1e9e424e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRM SHISAL1 MAN1C1 ATCAY	3.62e-05	181	46	4	ad30c01290fb98adbd0caed301a584761212c977
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRM SHISAL1 MAN1C1 ATCAY	3.62e-05	181	46	4	3a3268a4dff8ffcb79e09f46490e138c96f8d916
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	CPZ UTS2R NRXN2 RFX1	4.20e-05	188	46	4	c90669b51e1902fe7726555290c91c92a911df83
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NRXN1 NRXN2 ATCAY SCN9A	4.38e-05	190	46	4	6c7e1086c0a274cd5527c3104106e372811c9905
ToppCell	COPD-Myeloid-cDC2\|World / Disease state, Lineage and Cell class	OR2B11 ADAM19 DEXI MCOLN2	4.47e-05	191	46	4	4e4887175200a57e1b041f2f131e3df774df3509
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ADAM19 ITGAL TRGC1 MCOLN2	4.65e-05	193	46	4	00349d176fb6a46cbcc99c41d975651b6e9aaad4
ToppCell	medial-Hematologic-Plasmacytoid_Dendritic\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	UNC93B1 ADAM19 MCOLN2 SCN9A	4.75e-05	194	46	4	bb36274d6fe2d18c545a17d3809f331586502d01
ToppCell	medial-2-Hematologic-Plasmacytoid_Dendritic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	UNC93B1 ADAM19 MCOLN2 SCN9A	4.75e-05	194	46	4	d58be6454a0795d6771036a1620553a153861615
ToppCell	medial-Hematologic-Plasmacytoid_Dendritic-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	UNC93B1 ADAM19 MCOLN2 SCN9A	4.75e-05	194	46	4	0117cd68750153fd6b8978c8b4ce3589486d2b5f
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ADAM19 ITGAL TRGC1 MCOLN2	4.84e-05	195	46	4	31b011f3d54e6729802aad1f771cef77744e3ff2
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ADAM19 ITGAL TRGC1 MCOLN2	4.84e-05	195	46	4	36c784709ee32174e05b457500339c3b8eee3244
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-pDC-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	UNC93B1 ADAM19 MCOLN2 SCN9A	4.84e-05	195	46	4	06051de72b5c1e0d483a28b14dabd247dfca0ed9
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-pDC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	UNC93B1 ADAM19 MCOLN2 SCN9A	4.84e-05	195	46	4	3aa44633c72658545aa2b35bf9d532c62f36a451
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NRXN1 NRXN2 ATCAY SCN9A	5.04e-05	197	46	4	f7eaac1c321710a55e09ffb047a7db2baf7b7e28
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NRXN1 NRXN2 ATCAY SCN9A	5.24e-05	199	46	4	86739a6f5e0fa7448389b97b3c4de41f2a7d7ebd
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NRXN1 NRXN2 ATCAY SCN9A	5.34e-05	200	46	4	553e9612874480f4d2a45671462e266cd0a09321
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Mgp_(Mgp)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SLC6A13 CPZ SCN4A	1.84e-04	107	46	3	13af691c8533418d2800a8eca61155896b559948
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Mgp_(Mgp)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SLC6A13 CPZ SCN4A	1.84e-04	107	46	3	a5a34bb9706527799ddb494d4f1bfc634c29e8a9
ToppCell	COVID-19-kidney-Epithelial_Doublet\|kidney / Disease (COVID-19 only), tissue and cell type	NRXN1 OR9G4 ATCAY	2.84e-04	124	46	3	d6f59ddb9b9df02b5201f23fa5fb78f3fd891ee9
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_2\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SLC6A13 CPZ ADAM18	2.98e-04	126	46	3	83f3540683b3b175b10af059ab8898c46eaccc13
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SLC6A13 CPZ ADAM18	2.98e-04	126	46	3	f20424f9baf3c4059cd6b701761e7595400fc47c
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Nnat_(Nnat)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SLC6A13 CPZ ADAM18	2.98e-04	126	46	3	6d5075d659dac7b96e6857f8485a7d2c4105d685
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Nnat_(Nnat)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SLC6A13 CPZ ADAM18	2.98e-04	126	46	3	fd0001a0f3a0a4421f96fd21813c21cf6f01d40e
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SLC6A13 CPZ SCN4A	3.42e-04	132	46	3	893b7ec2a2d8a140cc98575d1beca1189f053e9a
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NRM MCOLN2 SCN9A	4.32e-04	143	46	3	5a279da1cd8e63db32f7c85a73b493c2121d0a96
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NRM MCOLN2 SCN9A	4.50e-04	145	46	3	997bd540c43725a85ca97e4b79ebe0d336860287
ToppCell	Adult-Immune-dendritic_cell-D231\|Adult / Lineage, Cell type, age group and donor	ADAM19 NRXN2 MCOLN2	4.68e-04	147	46	3	7cc4f74dd7a86247db8dc049ed7eadeb53825a96
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_TIP\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SLC6A13 CPZ ADAM18	4.87e-04	149	46	3	3980fa4f1986a2f164a1826ea043fb71f1d756cd
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Akr1c18_Ntf3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GOLIM4 MAN1C1 SCN9A	4.87e-04	149	46	3	1e77f03d2b32f366018fec3462d1b75f6e7febb9
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	PCSK7 TUT4 MCOLN2	5.06e-04	151	46	3	999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCell	severe_COVID-19-NK_CD56bright\|World / disease group, cell group and cell class (v2)	GOLIM4 ATCAY TRGC1	5.16e-04	152	46	3	ab5a4e47b23d16018642d4c9c7f41b30205edf73
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGAL SCN4A MCOLN2	5.36e-04	154	46	3	3fa6f77ad2c30ec24b9b904e2732ec5b419dff5b
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGAL SCN4A MCOLN2	5.36e-04	154	46	3	ee03b386d28a524084eaf1c0091f7389daa34250
ToppCell	Fetal_29-31_weeks-Immune-dendritic_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAM19 ITGAL MCOLN2	5.46e-04	155	46	3	9f937ae48767fdcf1a944af4de0530d9c0ab441d
ToppCell	droplet-Liver-Hepatocytes-18m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC93B1 NRXN1 ITGAL	5.77e-04	158	46	3	d3446fc98eff09c3626b47a2c90d07cd985378b5
ToppCell	droplet-Liver-Hepatocytes-18m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC93B1 NRXN1 ITGAL	5.77e-04	158	46	3	df614450e10629dc9115d7365397663e82f9e48f
ToppCell	severe_COVID-19-NK_CD56bright\|severe_COVID-19 / disease group, cell group and cell class (v2)	GOLIM4 ATCAY TRGC1	5.77e-04	158	46	3	c2e8d96fc29aa2388b92b4fd81d2726e1f7a053f
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SLC6A13 CPZ SCN4A	5.88e-04	159	46	3	cb2470b288c13e454a2a80115b0d5613b3f718e6
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|356C / Donor, Lineage, Cell class and subclass (all cells)	ATP6AP1L TRGC1 MCOLN2	5.88e-04	159	46	3	2fb1d2ff52920aeb48d048cf29f0cd45f944a73d
ToppCell	facs-Marrow-T-cells-24m-Hematologic-MPP_Fraction_B\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A13 SCN4A MCOLN2	5.99e-04	160	46	3	b3f7ef7e682b48a83ca425f5c439336e96168300
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM19 NRXN1 SCN9A	6.10e-04	161	46	3	7d1bc73f4c82465b3f489d6737048b0cd54f22cf
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM19 NRXN1 SCN9A	6.10e-04	161	46	3	410eef62c83c704cbfc5a1b643c4db11bbdcd81f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Neural\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM19 NRXN1 SCN9A	6.10e-04	161	46	3	71022485da6754a2b57b4c3e758e3de4c95cc292
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-Zbtb32+_B_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UNC93B1 SCN4A MCOLN2	6.10e-04	161	46	3	98be0cf8228496b31f7f3e0efd8787e95eb626d1
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UNC93B1 SCN4A MCOLN2	6.10e-04	161	46	3	7af3b0d4fc7967f6b3e2d255d23fd8b1fd01a7af
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM19 NRXN1 SCN9A	6.10e-04	161	46	3	59ae8a7c9a04ecaa335b8064852a5a91a21780bd
ToppCell	facs-Lung-Endomucin_-18m-Lymphocytic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A13 UNC93B1 SCN4A	6.21e-04	162	46	3	e81dec1db8e5a808d96e58410c91961e5d065c94
ToppCell	facs-Lung-Endomucin_-18m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A13 UNC93B1 SCN4A	6.21e-04	162	46	3	d19b469f64c9064cfb82dadb6c8135e28949a02a
ToppCell	facs-Lung-Endomucin_-18m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A13 UNC93B1 SCN4A	6.21e-04	162	46	3	10c2aa047f33f48e4abe676236bbdb593079dd1d
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM18 SCN4A MCOLN2	6.32e-04	163	46	3	2a561aa4518cf52d8470eff083b84f942a2b2b5d
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-NK_CD56bright\|Multiple_Sclerosis / Disease, Lineage and Cell Type	GOLIM4 PPP1R36 TRGC1	6.32e-04	163	46	3	82c4b25f05bd404fdee9aa90f23efd6dffc04e7b
ToppCell	COPD-Myeloid-DC_Langerhans\|Myeloid / Disease state, Lineage and Cell class	ADAM19 MCOLN2 SCN9A	6.43e-04	164	46	3	a07c6e13c07a90bc37db0915eb14931eb8309a1e
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRM SHISAL1 ADAM18	6.43e-04	164	46	3	0853e75b60b2a78257b660910c3ee15b09c5f5b0
ToppCell	NS-critical-d_07-13-Myeloid-pDC\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ADAM19 MCOLN2 SCN9A	6.55e-04	165	46	3	17d5c4a111d9b5400780bc5e7b93ce2f5d69ceb7
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM18 SCN4A MCOLN2	6.66e-04	166	46	3	6842735750dcb361e4c9844f05233b0fbb879652
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM19 NRXN1 SCN9A	6.66e-04	166	46	3	f742d15b02a6f651bbd00f53e3d871f40d05a03d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM19 NRXN1 SCN9A	6.66e-04	166	46	3	e941df9a1091164edde3def8fc7d410186b2bd88
ToppCell	droplet-Fat-SCAT-30m-Lymphocytic\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A13 ITGAL ATCAY	6.66e-04	166	46	3	7f4e5976ede6478636aa567d6fc2b56ff7295fb8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM19 NRXN1 SCN9A	6.66e-04	166	46	3	aeda46bea5d8463c24a83b98b9ed92d962d733e5
ToppCell	droplet-Fat-SCAT-30m-Lymphocytic-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A13 ITGAL ATCAY	6.66e-04	166	46	3	67370c49d7aedcb4eca802095f06b30f6bbf8919
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Neural\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM19 NRXN1 SCN9A	6.66e-04	166	46	3	0f013bb5fdb72e88c2fc73d60cd01551a2db6341
ToppCell	356C-Myeloid-Dendritic-cDC1\|356C / Donor, Lineage, Cell class and subclass (all cells)	ADAM19 CAMSAP1 MCOLN2	6.66e-04	166	46	3	0590e404f45afce90e20f93f90a3def83949c66b
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NRXN1 NRXN2 SCN9A	6.78e-04	167	46	3	17c653b46507c8bb85da95836ae72a6015336142
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ADAM19 ANO10 CAMSAP1	6.90e-04	168	46	3	d7d19c93d1c3dd994e18e28d5f36ae7773ff5d7f
ToppCell	NS-moderate-d_07-13-Myeloid-pDC\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ADAM19 MCOLN2 SCN9A	6.90e-04	168	46	3	d03e91f0e0518b33555c0ec98124fc5ed0f11be5
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NRXN1 NRXN2 SCN9A	7.02e-04	169	46	3	2456b3e7776e8a2214972be1b4d66a3ca5480ae0
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic-CD1c-positive_myeloid_dendritic_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ADAM19 ZMIZ2 MCOLN2	7.14e-04	170	46	3	cc66ac6846c58be9493eb270644ee3ce0f86cfea
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-CD45____B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHEK2 NRM MCOLN2	7.14e-04	170	46	3	6210ee3bf29059e6149c047bb7e02c5f59441519
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAM19 MCOLN2 SCN9A	7.26e-04	171	46	3	4fd2c7977c512c51507f055fc74b111c0228ed8b
ToppCell	COVID-19_Convalescent-cDC-\|COVID-19_Convalescent / Disease condition and Cell class	TRGC1 MCOLN2 SCN9A	7.26e-04	171	46	3	fb5fae8b3adafcbb7c5618d887966b418355ed4d
ToppCell	COVID-19_Convalescent-cDC\|COVID-19_Convalescent / Disease condition and Cell class	TRGC1 MCOLN2 SCN9A	7.26e-04	171	46	3	9ccaa9f1629818b0f63a5d930ee78c01e04cd98d
ToppCell	facs-Spleen-nan-24m-Lymphocytic-CD79a_B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRM UNC93B1 ZMIZ2	7.39e-04	172	46	3	0c6332a806ac75fffae6080f61965555c7f687f4
ToppCell	5'-Adult-Distal_Rectal-Hematopoietic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZMIZ2 SCN8A SCN9A	7.51e-04	173	46	3	b335ca2a247156eba821943b2b9fc9922230b409
ToppCell	mild_COVID-19_(asymptomatic)-gd_T\|World / disease group, cell group and cell class (v2)	SLC6A13 TRGC1 MCOLN2	7.51e-04	173	46	3	b6615ff02f5017d7150b1e33b53f8c7a26081a0d
ToppCell	Dendritic_Cells-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	ADAM19 ATCAY MCOLN2	7.51e-04	173	46	3	ddb900ef4abeabe2e59db1009efc337e35d301fe
ToppCell	facs-Spleen-nan-24m-Lymphocytic-B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRM UNC93B1 ZMIZ2	7.64e-04	174	46	3	a0641908ab6feaca5cd07142d7429983a2f68668
ToppCell	3'-Distal_airway-Immune_Myeloid-Dendritic-dendritic_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAM19 NRXN2 MCOLN2	7.76e-04	175	46	3	393da565f61ba640410419a0cabaaf5c1056580a
ToppCell	3'-Distal_airway-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAM19 NRXN2 MCOLN2	7.76e-04	175	46	3	271b56d4ab940959d28ca4b86ce2750350dfc717
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	GOLIM4 ITGAL TRGC1	7.76e-04	175	46	3	8fb8c4b9e2d9b7d737f59cd9bd3dc2bca5a8dfc4
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CHEK2 NRXN1 SCN8A	7.76e-04	175	46	3	3e56695a9db97cb1d3503425c48eb79bbf99213e
ToppCell	3'-Distal_airway-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs-Migratory_DCs_L.1.2.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAM19 NRXN2 MCOLN2	7.76e-04	175	46	3	5168340c6045bbc7d67276afb719b051d1cb65a2
ToppCell	droplet-Pancreas-PANCREAS-30m-Hematologic-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGAL ATCAY MCOLN2	7.76e-04	175	46	3	ca2eabf03b70353e7eb15b6f622b2f9223a99e18
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC93B1 SCN4A MCOLN2	7.89e-04	176	46	3	741fdacb33d49b030a797a6099fdea0949a22e75
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|normal_Lymph_Node / Location, Cell class and cell subclass	ADAM19 ZMIZ2 MCOLN2	7.89e-04	176	46	3	476794ef75ce5ab732d78cfeb4944e2f841e3e92
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC93B1 SCN4A MCOLN2	7.89e-04	176	46	3	dbb1c7cc6e404593b62e79b1fb815bc65ff49cae
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TUT4 ITGAL TRGC1	8.02e-04	177	46	3	d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NRXN1 NRXN2 SCN9A	8.02e-04	177	46	3	d05497d2c80a66ec6a4e1733fea3a5534877a6a7
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TUT4 ITGAL TRGC1	8.02e-04	177	46	3	f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCell	droplet-Fat-SCAT-30m-Lymphocytic-T_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A13 ITGAL ATCAY	8.02e-04	177	46	3	baf78a8dad55f124f56585f88b10b58c0269680f
Drug	Dibucaine [85-79-0]; Up 200; 11.6uM; PC3; HT_HG-U133A	HTR4 ITGAL NRXN2 RFX1 CRAT ZMIZ2	2.21e-06	199	44	6	4068_UP
Drug	Limber	SLC6A7 PCSK7 ATCAY	7.50e-06	20	44	3	CID003083543
Drug	dibucaine	CHEK2 PCSK7 SCN4A SCN9A	9.03e-06	68	44	4	CID000003025
Drug	N-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide	SCN4A SCN9A	1.09e-05	3	44	2	ctd:C561228
Drug	Etifenin [63245-28-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A	RNFT1 PCSK7 ADAM19 CAMSAP1 ZMIZ2	3.54e-05	194	44	5	2838_UP
Drug	6-Furfurylaminopurine [525-79-1]; Up 200; 18.6uM; MCF7; HT_HG-U133A	SLC6A13 TUT4 HTR4 CAMSAP1 RFX1	3.90e-05	198	44	5	6073_UP
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN4A SCN8A SCN9A	4.51e-07	10	47	3	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN4A SCN8A SCN9A	4.51e-07	10	47	3	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN4A SCN8A SCN9A	8.25e-07	12	47	3	DOID:0060170 (implicated_via_orthology)
Disease	B Virus Infection	SCN8A SCN9A	7.44e-06	3	47	2	C0037140
Disease	Postherpetic neuralgia	SCN8A SCN9A	7.44e-06	3	47	2	C0032768
Disease	Herpesviridae Infections	SCN8A SCN9A	7.44e-06	3	47	2	C0019372
Disease	triacylglycerol 58:10 measurement	NRXN1 ATP6AP1L SCN9A	2.19e-05	34	47	3	EFO_0010437
Disease	Epilepsy	PIGH SCN8A SCN9A	7.06e-04	109	47	3	C0014544

Protein segments in the cluster

Peptide	Gene	Start	Entry
LNSMKYVELYLVADY	ADAM19	206	Q9H013
LEIYIIVEKALYDYM	ADAM18	186	Q9Y3Q7
AFIQMALQLAYYRIY	CRAT	431	P43155
LYFYQMLLAVQYLHE	CHEK2	326	O96017
LYYAFLMEYIVLNVG	DEXI	41	O95424
YLNKCFYLTLEDMLY	CAMSAP1	296	Q5T5Y3
YAIVIEIMNRLYRYA	ANO10	366	Q9NW15
AALCILILLYAMYKY	NRXN1	406	P58400
VLADLVMLTLYFYYK	SLC66A1	106	Q6ZP29
DYHYIMENLFLYVIS	ATCAY	206	Q86WG3
YYLEILMVTGLLAYI	CCDC47	136	Q96A33
YYMLEVYLSQRNVAS	PCSK7	681	Q16549
AALCILILLYAMYKY	NRXN2	1646	Q9P2S2
YAELMGLKQVYYHVL	NRM	161	Q8IXM6
AALCILILLYAMYKY	NRXN1	1411	Q9ULB1
MSVKYHYELLNYIDL	DDX18	436	Q9NVP1
IVSLFYLPAIYMYLQ	OR2B11	251	Q5JQS5
VVAYTECYLLAAMAY	OR9G4	121	Q8NGQ1
FLYGAMLYYELQTQL	GOLIM4	26	O00461
LLAAMAYDRYVAIYN	OR5T1	126	Q8NG75
EMLIYLAQYLCSEYL	CPZ	256	Q66K79
LLMVLAYYRIYVTAK	HTR4	206	Q13639
KNMYYEALEAIETYL	MAN1C1	411	Q9NR34
ALPELIYYIILYMQI	IPO9	356	Q96P70
IYYIILYMQITEEQI	IPO9	361	Q96P70
VLGDMLNIYYAYIQA	FAM87A	176	P0C7U9
YLGYFQAYNVLILTM	MCOLN2	396	Q8IZK6
VVILYYGAALSMYLK	OR2K2	246	Q8NGT1
FYLINLILAVVAMAY	SCN4A	436	P35499
LQLTNTSAYYMYLLL	TRGC1	131	P0CF51
HLIRLLYDEYMYYLI	RFX1	876	P22670
CELYLLSIMAYDRYV	OR5AL1	126	P0C617
FYLINLILAVVAMAY	SCN9A	391	Q15858
MLLVLDLLYYSAMNY	SHISAL1	111	Q3SXP7
VDVVYEKQMLYLYVL	ITGAL	1081	P20701
RAVDLMTHNYYELLY	NUP160	1071	Q12769
VGLVAIYYNMIIAYV	SLC6A7	126	Q99884
YMLLEELCQYYRTFV	RNFT1	286	Q5M7Z0
QLPMIYFLNHYLYDL	UNC93B1	236	Q9H1C4
YASQMIVILLNVYYI	SLC6A13	116	Q9NSD5
EAIYMQKVIYYLCIL	PIGH	126	Q14442
YLVNLILAVVAMAYE	SCN8A	401	Q9UQD0
NFLMALLYYLSHYLE	PPP1R36	151	Q96LQ0
YMLGILIYIQNSDYE	ZMIZ2	656	Q8NF64
MYVYVVNLALADLLY	UTS2R	86	Q9UKP6
SYAYILMVLYFLQQR	TUT4	1121	Q5TAX3
VYCLRTEYIADYLMQ	TOPBP1	1461	Q92547
LVLAYALHMLIYLRY	ATP6AP1L	161	Q52LC2
ALHMLIYLRYLDQQY	ATP6AP1L	166	Q52LC2
VELYYMILERLGKYQ	NAA25	196	Q14CX7