Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calmodulin-dependent protein phosphatase activity	PPP3CA PPP3CB	4.94e-05	5	45	2	GO:0033192
GeneOntologyMolecularFunction	intracellularly cGMP-activated cation channel activity	CNGA1 CNGB3	1.04e-04	7	45	2	GO:0005223
GeneOntologyMolecularFunction	calcium-dependent protein serine/threonine phosphatase activity	PPP3CA PPP3CB	1.38e-04	8	45	2	GO:0004723
GeneOntologyMolecularFunction	intracellularly cAMP-activated cation channel activity	CNGA1 CNGB3	2.21e-04	10	45	2	GO:0005222
GeneOntologyMolecularFunction	intracellularly cyclic nucleotide-activated monoatomic cation channel activity	CNGA1 CNGB3	3.81e-04	13	45	2	GO:0005221
GeneOntologyMolecularFunction	cyclic nucleotide-activated monoatomic ion channel activity	CNGA1 CNGB3	3.81e-04	13	45	2	GO:0043855
GeneOntologyMolecularFunction	cGMP binding	CNGA1 CNGB3	5.84e-04	16	45	2	GO:0030553
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	PRAMEF9 PRAMEF27 PRAMEF15	8.36e-04	82	45	3	GO:1990756
GeneOntologyMolecularFunction	phospholipid scramblase activity	ANO7 ATG9A	1.22e-03	23	45	2	GO:0017128
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	PRAMEF9 PRAMEF27 PRAMEF15	1.28e-03	95	45	3	GO:0140767
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	CNGA1 CNGB3	2.51e-03	33	45	2	GO:0005217
GeneOntologyBiologicalProcess	transition between fast and slow fiber	GTF2IRD2 GTF2IRD2B PPP3CA	2.38e-06	13	43	3	GO:0014883
GeneOntologyBiologicalProcess	regulation of skeletal muscle adaptation	GTF2IRD2 GTF2IRD2B PPP3CA	9.39e-06	20	43	3	GO:0014733
GeneOntologyBiologicalProcess	skeletal muscle adaptation	GTF2IRD2 GTF2IRD2B PPP3CA	4.01e-05	32	43	3	GO:0043501
GeneOntologyBiologicalProcess	calcium ion import across plasma membrane	TRPM1 PPP3CA PPP3CB	1.37e-04	48	43	3	GO:0098703
GeneOntologyBiologicalProcess	calcium ion import into cytosol	TRPM1 PPP3CA PPP3CB	1.37e-04	48	43	3	GO:1902656
GeneOntologyBiologicalProcess	negative regulation of calcium ion import across plasma membrane	PPP3CA PPP3CB	1.51e-04	9	43	2	GO:1905949
GeneOntologyBiologicalProcess	calcium ion transmembrane transport	UBR3 RGS9 TRPM1 PPP3CA PPP3CB CNGA1	1.53e-04	392	43	6	GO:0070588
GeneOntologyCellularComponent	calcineurin complex	PPP3CA PPP3CB	6.76e-05	6	45	2	GO:0005955
GeneOntologyCellularComponent	intracellular cyclic nucleotide activated cation channel complex	CNGA1 CNGB3	9.45e-05	7	45	2	GO:0017071
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF9 PRAMEF27 PRAMEF15	1.41e-04	47	45	3	GO:0031462
GeneOntologyCellularComponent	ubiquitin ligase complex	UBR3 PRAMEF9 PRAMEF27 PRAMEF15 BUB1B	9.25e-04	352	45	5	GO:0000151
GeneOntologyCellularComponent	intracellular protein-containing complex	UBR3 PPP3CA PRAMEF9 PPP3CB PRAMEF27 PRIMPOL PRAMEF15 BUB1B	9.88e-04	972	45	8	GO:0140535
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	PRAMEF9 PRAMEF27 PRAMEF15 BUB1B	1.11e-03	212	45	4	GO:0031461
GeneOntologyCellularComponent	mRNA cleavage factor complex	CSTF3 SYMPK	2.03e-03	31	45	2	GO:0005849
Domain	-	GTF2IRD2 GTF2IRD2B	3.24e-05	4	44	2	3.90.1460.10
Domain	GTF2I	GTF2IRD2 GTF2IRD2B	3.24e-05	4	44	2	IPR004212
Domain	GTF2I	GTF2IRD2 GTF2IRD2B	3.24e-05	4	44	2	PS51139
Domain	GTF2I	GTF2IRD2 GTF2IRD2B	3.24e-05	4	44	2	PF02946
Domain	6-blade_b-propeller_TolB-like	WRAP73 LRP1B WDR6	1.73e-04	46	44	3	IPR011042
Domain	AAA+_ATPase	RNF213 ABCA5 ABCC10 DNAH11	3.62e-04	144	44	4	IPR003593
Domain	AAA	RNF213 ABCA5 ABCC10 DNAH11	3.62e-04	144	44	4	SM00382
Domain	Ser/Thr-sp_prot-phosphatase	PPP3CA PPP3CB	4.16e-04	13	44	2	IPR006186
Domain	SER_THR_PHOSPHATASE	PPP3CA PPP3CB	4.16e-04	13	44	2	PS00125
Domain	PP2Ac	PPP3CA PPP3CB	4.16e-04	13	44	2	SM00156
Domain	cNMP-bd_CS	CNGA1 CNGB3	6.37e-04	16	44	2	IPR018488
Domain	PRAME_family	PRAMEF27 PRAMEF15	9.04e-04	19	44	2	IPR026271
Domain	Calcineurin-like_PHP_ApaH	PPP3CA PPP3CB	1.97e-03	28	44	2	IPR004843
Domain	Metallophos	PPP3CA PPP3CB	1.97e-03	28	44	2	PF00149
Domain	Metallo-depent_PP-like	PPP3CA PPP3CB	2.26e-03	30	44	2	IPR029052
Domain	-	PPP3CA PPP3CB	2.26e-03	30	44	2	3.60.21.10
Domain	Ion_trans_dom	TRPM1 CNGA1 CNGB3	2.44e-03	114	44	3	IPR005821
Domain	Ion_trans	TRPM1 CNGA1 CNGB3	2.44e-03	114	44	3	PF00520
Domain	CNMP_BINDING_1	CNGA1 CNGB3	2.57e-03	32	44	2	PS00888
Domain	CNMP_BINDING_2	CNGA1 CNGB3	2.57e-03	32	44	2	PS00889
Domain	cNMP	CNGA1 CNGB3	2.90e-03	34	44	2	SM00100
Domain	cNMP_binding	CNGA1 CNGB3	2.90e-03	34	44	2	PF00027
Domain	cNMP-bd_dom	CNGA1 CNGB3	3.07e-03	35	44	2	IPR000595
Domain	CNMP_BINDING_3	CNGA1 CNGB3	3.07e-03	35	44	2	PS50042
Domain	cNMP-bd-like	CNGA1 CNGB3	3.61e-03	38	44	2	IPR018490
Domain	ABC_transporter_CS	ABCA5 ABCC10	4.40e-03	42	44	2	IPR017871
Domain	ABC_TRANSPORTER_2	ABCA5 ABCC10	5.71e-03	48	44	2	PS50893
Domain	ABC_tran	ABCA5 ABCC10	5.71e-03	48	44	2	PF00005
Domain	-	CNGA1 CNGB3	5.71e-03	48	44	2	2.60.120.10
Domain	ABC_TRANSPORTER_1	ABCA5 ABCC10	5.95e-03	49	44	2	PS00211
Domain	ABC_transporter-like	ABCA5 ABCC10	6.18e-03	50	44	2	IPR003439
Domain	RmlC-like_jellyroll	CNGA1 CNGB3	6.43e-03	51	44	2	IPR014710
Domain	TPR_8	TTC21B UTY	6.93e-03	53	44	2	PF13181
Pathway	REACTOME_CALCINEURIN_ACTIVATES_NFAT	PPP3CA PPP3CB	1.67e-04	9	31	2	M27106
Pathway	KEGG_MEDICUS_REFERENCE_LYSOSOMAL_CA2_RELEASE	PPP3CA PPP3CB	2.08e-04	10	31	2	M47954
Pathway	REACTOME_CALCINEURIN_ACTIVATES_NFAT	PPP3CA PPP3CB	2.54e-04	11	31	2	MM14810
Pathway	REACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION	PPP3CA PPP3CB	2.54e-04	11	31	2	M27466
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_CN_SIGNALING_PATHWAY	PPP3CA PPP3CB	3.05e-04	12	31	2	M47956
Pathway	BIOCARTA_PGC1A_PATHWAY	PPP3CA PPP3CB	4.19e-04	14	31	2	MM1473
Pathway	BIOCARTA_PGC1A_PATHWAY	PPP3CA PPP3CB	4.83e-04	15	31	2	M15181
Pathway	BIOCARTA_NDKDYNAMIN_PATHWAY	PPP3CA PPP3CB	4.83e-04	15	31	2	MM1387
Pathway	BIOCARTA_MEF2D_PATHWAY	PPP3CA PPP3CB	5.51e-04	16	31	2	MM1483
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_CALCINEURIN_SIGNALING_PATHWAY	PPP3CA PPP3CB	5.51e-04	16	31	2	M47449
Pathway	BIOCARTA_NDKDYNAMIN_PATHWAY	PPP3CA PPP3CB	6.24e-04	17	31	2	M5940
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAQ_PLCB_G_CALCINEURIN	PPP3CA PPP3CB	6.24e-04	17	31	2	M47560
Pathway	WP_CILIOPATHIES	TTC21B CPLANE1 CNGA1 DNAH11	6.71e-04	184	31	4	M39880
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	PPP3CA PPP3CB	7.01e-04	18	31	2	M3430
Pathway	BIOCARTA_MEF2D_PATHWAY	PPP3CA PPP3CB	7.01e-04	18	31	2	M5290
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	PPP3CA PPP3CB	7.01e-04	18	31	2	MM1385
Pathway	KEGG_MEDICUS_REFERENCE_BCR_PLCG_CALCINEURIN_SIGNALING_PATHWAY	PPP3CA PPP3CB	7.01e-04	18	31	2	M47580
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY	PPP3CA PPP3CB	7.82e-04	19	31	2	M47543
Pathway	BIOCARTA_NOS1_PATHWAY	PPP3CA PPP3CB	8.68e-04	20	31	2	MM1445
Pathway	REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS	CSTF3 SYMPK	8.68e-04	20	31	2	MM15469
Pathway	REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS	CSTF3 SYMPK	8.68e-04	20	31	2	M497
Pathway	WP_CALCIUM_MEDIATED_TCELL_APOPTOSIS_INVOLVED_IN_INCLUSION_BODY_MYOSITIS	PPP3CA PPP3CB	8.68e-04	20	31	2	M48330
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY	PPP3CA PPP3CB	9.58e-04	21	31	2	M47542
Pathway	BIOCARTA_NOS1_PATHWAY	PPP3CA PPP3CB	9.58e-04	21	31	2	M11650
Pathway	PID_RHODOPSIN_PATHWAY	RGS9 CNGA1	1.15e-03	23	31	2	M204
Pathway	PID_CONE_PATHWAY	RGS9 CNGB3	1.15e-03	23	31	2	M117
Pathway	WP_PHYSIOLOGICAL_AND_PATHOLOGICAL_HYPERTROPHY_OF_THE_HEART	PPP3CA PPP3CB	1.25e-03	24	31	2	M39576
Pathway	REACTOME_DARPP_32_EVENTS	PPP3CA PPP3CB	1.25e-03	24	31	2	M751
Pathway	BIOCARTA_VIP_PATHWAY	PPP3CA PPP3CB	1.36e-03	25	31	2	MM1441
Pathway	BIOCARTA_HDAC_PATHWAY	PPP3CA PPP3CB	1.36e-03	25	31	2	M1547
Pathway	BIOCARTA_VIP_PATHWAY	PPP3CA PPP3CB	1.47e-03	26	31	2	M17941
Pathway	BIOCARTA_HDAC_PATHWAY	PPP3CA PPP3CB	1.47e-03	26	31	2	MM1371
Pathway	PID_TCR_CALCIUM_PATHWAY	PPP3CA PPP3CB	1.71e-03	28	31	2	M235
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA	CSTF3 SYMPK	1.83e-03	29	31	2	M783
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA	CSTF3 SYMPK	1.83e-03	29	31	2	MM15444
Pathway	BIOCARTA_GPCR_PATHWAY	PPP3CA PPP3CB	1.83e-03	29	31	2	MM1495
Pathway	BIOCARTA_GPCR_PATHWAY	PPP3CA PPP3CB	1.96e-03	30	31	2	M9664
Pathway	REACTOME_THE_PHOTOTRANSDUCTION_CASCADE	RGS9 CNGA1	2.09e-03	31	31	2	MM14896
Pathway	BIOCARTA_BCR_PATHWAY	PPP3CA PPP3CB	2.23e-03	32	31	2	MM1355
Pathway	PID_IL12_STAT4_PATHWAY	PPP3CA PPP3CB	2.23e-03	32	31	2	M290
Pathway	WP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR	PPP3CA PPP3CB	2.23e-03	32	31	2	M39521
Pathway	BIOCARTA_BCR_PATHWAY	PPP3CA PPP3CB	2.37e-03	33	31	2	M9494
Pathway	REACTOME_THE_PHOTOTRANSDUCTION_CASCADE	RGS9 CNGA1	2.51e-03	34	31	2	M27183
Pathway	BIOCARTA_FMLP_PATHWAY	PPP3CA PPP3CB	2.51e-03	34	31	2	M10287
Pathway	BIOCARTA_FMLP_PATHWAY	PPP3CA PPP3CB	2.51e-03	34	31	2	MM1399
Pathway	WP_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS	PPP3CA PPP3CB	3.13e-03	38	31	2	M39357
Pathway	BIOCARTA_FCER1_PATHWAY	PPP3CA PPP3CB	3.30e-03	39	31	2	M1908
Pathway	BIOCARTA_FCER1_PATHWAY	PPP3CA PPP3CB	3.30e-03	39	31	2	MM1397
Pathway	WP_GLYCOSAMINOGLYCAN_SYNTHESIS_IN_FIBROBLASTS	NDST1 DSE	3.64e-03	41	31	2	M48095
Pathway	BIOCARTA_TCR_PATHWAY	PPP3CA PPP3CB	3.81e-03	42	31	2	MM1504
Pathway	BIOCARTA_TCR_PATHWAY	PPP3CA PPP3CB	4.18e-03	44	31	2	M19784
Pathway	KEGG_ABC_TRANSPORTERS	ABCA5 ABCC10	4.18e-03	44	31	2	M11911
Pathway	REACTOME_CA2_PATHWAY	PPP3CA PPP3CB	4.37e-03	45	31	2	MM15040
Pathway	SIG_BCR_SIGNALING_PATHWAY	PPP3CA PPP3CB	4.56e-03	46	31	2	M8626
Pathway	WP_NOCGMPPKG_MEDIATED_NEUROPROTECTION	CNGA1 CNGB3	4.76e-03	47	31	2	M39531
Pathway	WP_ENERGY_METABOLISM	PPP3CA PPP3CB	4.96e-03	48	31	2	M39590
Pathway	BIOCARTA_NFAT_PATHWAY	PPP3CA PPP3CB	5.16e-03	49	31	2	MM1442
Pathway	BIOCARTA_NFAT_PATHWAY	PPP3CA PPP3CB	5.58e-03	51	31	2	M2288
Pathway	PID_NFAT_3PATHWAY	PPP3CA PPP3CB	6.01e-03	53	31	2	M113
Pathway	KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS	PPP3CA PPP3CB	6.01e-03	53	31	2	M3812
Pathway	REACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION	PPP3CA PPP3CB	7.17e-03	58	31	2	MM14914
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION_TERMINATION	CSTF3 SYMPK	8.15e-03	62	31	2	MM15426
Pathway	REACTOME_CA2_PATHWAY	PPP3CA PPP3CB	8.15e-03	62	31	2	M27321
Pathway	PID_IL12_2PATHWAY	PPP3CA PPP3CB	8.15e-03	62	31	2	M54
Pathway	PID_BCR_5PATHWAY	PPP3CA PPP3CB	8.41e-03	63	31	2	M10
Pathway	PID_CD8_TCR_DOWNSTREAM_PATHWAY	PPP3CA PPP3CB	8.93e-03	65	31	2	M272
Pubmed	Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity.	PPP3CA PPP3CB	1.64e-06	2	45	2	19861587
Pubmed	Are calcineurin genes associated with athletic status? A function, replication study.	PPP3CA PPP3CB	1.64e-06	2	45	2	21233773
Pubmed	Coexpression of calcineurin A and B subunits in various subcellular and synaptic compartments of cerebellar neurons and glia with particular abundance at parallel fiber-Purkinje cell synapses.	PPP3CA PPP3CB	1.64e-06	2	45	2	35247520
Pubmed	Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.	PPP3CA PPP3CB	1.64e-06	2	45	2	2556704
Pubmed	Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.	GTF2IRD2 GTF2IRD2B	1.64e-06	2	45	2	15388857
Pubmed	Inhibition of calcineurin phosphatase promotes exocytosis of renin from juxtaglomerular cells.	PPP3CA PPP3CB	1.64e-06	2	45	2	19907416
Pubmed	Chromosomal assignments of the genes for the calcineurin A alpha (Calna1) and A beta subunits (Calna2) in the rat.	PPP3CA PPP3CB	1.64e-06	2	45	2	8187553
Pubmed	Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2.	PPP3CA PPP3CB	1.64e-06	2	45	2	11005320
Pubmed	Oxidation-induced conformational changes in calcineurin determined by covalent labeling and tandem mass spectrometry.	PPP3CA PPP3CB	1.64e-06	2	45	2	25286016
Pubmed	The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses.	PPP3CA PPP3CB	1.64e-06	2	45	2	20810903
Pubmed	Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase.	PPP3CA PPP3CB	1.64e-06	2	45	2	1328240
Pubmed	Calcineurin expression and activity is regulated by the intracellular redox status and under hypertension in human neutrophils.	PPP3CA PPP3CB	1.64e-06	2	45	2	22739212
Pubmed	Compensatory renal hypertrophy following uninephrectomy is calcineurin-independent.	PPP3CA PPP3CB	1.64e-06	2	45	2	25287476
Pubmed	Calcineurin A-alpha but not A-beta is required for normal kidney development and function.	PPP3CA PPP3CB	1.64e-06	2	45	2	15509543
Pubmed	Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis.	PPP3CA PPP3CB BUB1B	3.06e-06	22	45	3	21690297
Pubmed	A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome.	RGS9 CNGA1 CNGB3 BUB1B	3.78e-06	81	45	4	16110338
Pubmed	Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively.	PPP3CA PPP3CB	4.91e-06	3	45	2	8978785
Pubmed	Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.	GTF2IRD2 GTF2IRD2B	4.91e-06	3	45	2	15100712
Pubmed	Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods.	PPP3CA PPP3CB	4.91e-06	3	45	2	2162844
Pubmed	Segregation of a mutation in CNGB1 encoding the beta-subunit of the rod cGMP-gated channel in a family with autosomal recessive retinitis pigmentosa.	CNGA1 CNGB3	4.91e-06	3	45	2	11379879
Pubmed	Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha).	PPP3CA PPP3CB	4.91e-06	3	45	2	8392375
Pubmed	Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.	PPP3CA PPP3CB	4.91e-06	3	45	2	7593193
Pubmed	Cooperative autoinhibition and multi-level activation mechanisms of calcineurin.	PPP3CA PPP3CB	4.91e-06	3	45	2	26794871
Pubmed	Tau binds both subunits of calcineurin, and binding is impaired by calmodulin.	PPP3CA PPP3CB	4.91e-06	3	45	2	18639592
Pubmed	Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit.	PPP3CA PPP3CB	4.91e-06	3	45	2	1659808
Pubmed	Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes.	PPP3CA PPP3CB	4.91e-06	3	45	2	9655484
Pubmed	Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs.	PPP3CA PPP3CB	4.91e-06	3	45	2	20700529
Pubmed	Calcineurin signaling and PGC-1alpha expression are suppressed during muscle atrophy due to diabetes.	PPP3CA PPP3CB	4.91e-06	3	45	2	20359506
Pubmed	Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice.	PPP3CA PPP3CB	4.91e-06	3	45	2	12773574
Pubmed	The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding.	PPP3CA PPP3CB	4.91e-06	3	45	2	19154138
Pubmed	Calcineurin protects the heart in a murine model of dilated cardiomyopathy.	PPP3CA PPP3CB	4.91e-06	3	45	2	19854199
Pubmed	Myospryn is a calcineurin-interacting protein that negatively modulates slow-fiber-type transformation and skeletal muscle regeneration.	PPP3CA PPP3CB	4.91e-06	3	45	2	21427212
Pubmed	Catalytic subunits of the phosphatase calcineurin interact with NF-κB-inducing kinase (NIK) and attenuate NIK-dependent gene expression.	PPP3CA PPP3CB	9.81e-06	4	45	2	26029823
Pubmed	Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions.	GTF2IRD2 GTF2IRD2B	9.81e-06	4	45	2	21328569
Pubmed	Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB.	PPP3CA PPP3CB	9.81e-06	4	45	2	25720963
Pubmed	TFII-I gene family during tooth development: candidate genes for tooth anomalies in Williams syndrome.	GTF2IRD2 GTF2IRD2B	9.81e-06	4	45	2	17823943
Pubmed	Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents.	PPP3CA PPP3CB	9.81e-06	4	45	2	19287093
Pubmed	Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy.	PPP3CA PPP3CB	9.81e-06	4	45	2	15082723
Pubmed	Evolution of general transcription factors.	GTF2IRD2 GTF2IRD2B	9.81e-06	4	45	2	23229069
Pubmed	miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export.	PPP3CA PPP3CB	9.81e-06	4	45	2	24336651
Pubmed	Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells.	PPP3CA PPP3CB	9.81e-06	4	45	2	11714752
Pubmed	Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.	PPP3CA PPP3CB	9.81e-06	4	45	2	12809556
Pubmed	GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.	GTF2IRD2 GTF2IRD2B	9.81e-06	4	45	2	22899722
Pubmed	Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1.	CNGA1 CNGB3	9.81e-06	4	45	2	15634774
Pubmed	Molecular and phylogenetic analysis of calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit genes.	PPP3CA PPP3CB	9.81e-06	4	45	2	1318721
Pubmed	Are calcineurin genes associated with endurance phenotype traits?	PPP3CA PPP3CB	1.63e-05	5	45	2	20107831
Pubmed	Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex.	PPP3CA PPP3CB	1.63e-05	5	45	2	8524402
Pubmed	Developmental regulation of calcineurin isoforms in the rodent kidney: association with COX-2.	PPP3CA PPP3CB	1.63e-05	5	45	2	17881460
Pubmed	The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry.	CNGA1 CNGB3	1.63e-05	5	45	2	12432397
Pubmed	Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults.	PPP3CA PPP3CB	1.63e-05	5	45	2	20593291
Pubmed	[Expression profile of calcineurin pathway genes in myocardium tissues in relation to ischemic heart remodeling in humans].	PPP3CA PPP3CB	1.63e-05	5	45	2	23888774
Pubmed	Elevated expression of calcineurin subunits during active mineralization of developing mouse molar teeth.	PPP3CA PPP3CB	1.63e-05	5	45	2	22984995
Pubmed	Calcineurin: form and function.	PPP3CA PPP3CB	1.63e-05	5	45	2	11015619
Pubmed	Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy.	PPP3CA PPP3CB	1.63e-05	5	45	2	22688515
Pubmed	Calcineurin Links Mitochondrial Elongation with Energy Metabolism.	PPP3CA PPP3CB	1.63e-05	5	45	2	26411342
Pubmed	cGMP and cyclic nucleotide-gated channels participate in mouse sperm capacitation.	CNGA1 CNGB3	2.45e-05	6	45	2	22192355
Pubmed	CIB1 is a regulator of pathological cardiac hypertrophy.	PPP3CA PPP3CB	2.45e-05	6	45	2	20639889
Pubmed	Mammalian brain phosphoproteins as substrates for calcineurin.	PPP3CA PPP3CB	2.45e-05	6	45	2	6330098
Pubmed	Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D.	PPP3CA PPP3CB	2.45e-05	6	45	2	20647544
Pubmed	Low affinity Ca2+-binding sites of calcineurin B mediate conformational changes in calcineurin A.	PPP3CA PPP3CB	3.42e-05	7	45	2	11123943
Pubmed	The protein serine/threonine phosphatases PP2A, PP1 and calcineurin: A triple threat in the regulation of the neuronal cytoskeleton.	PPP3CA PPP3CB	3.42e-05	7	45	2	28126489
Pubmed	Complex protein interactions within the human polyadenylation machinery identify a novel component.	CSTF3 SYMPK	3.42e-05	7	45	2	10669729
Pubmed	Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity.	PPP3CA PPP3CB	3.42e-05	7	45	2	8631904
Pubmed	AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling.	PPP3CA PPP3CB	4.56e-05	8	45	2	17640527
Pubmed	Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.	PPP3CA PPP3CB	5.86e-05	9	45	2	11114196
Pubmed	Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling.	PPP3CA PPP3CB	5.86e-05	9	45	2	22343722
Pubmed	Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation.	PPP3CA INPP4B	5.86e-05	9	45	2	21070662
Pubmed	SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.	PPP3CA PPP3CB	5.86e-05	9	45	2	34446558
Pubmed	International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.	CNGA1 CNGB3	7.32e-05	10	45	2	16382102
Pubmed	Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly.	KNTC1 BUB1B	7.32e-05	10	45	2	19468067
Pubmed	Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.	PPP3CA PPP3CB	8.94e-05	11	45	2	11842093
Pubmed	A reassessment of the inhibitory capacity of human FKBP38 on calcineurin.	PPP3CA PPP3CB	1.07e-04	12	45	2	15757646
Pubmed	Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding.	PPP3CA PPP3CB	1.07e-04	12	45	2	24905733
Pubmed	Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions.	PPP3CA PPP3CB	1.47e-04	14	45	2	28826478
Pubmed	Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients.	PPP3CA PPP3CB	1.70e-04	15	45	2	21047202
Pubmed	Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure.	PPP3CA PPP3CB	2.20e-04	17	45	2	24086760
Pubmed	Transcriptional fates of human-specific segmental duplications in brain.	GTF2IRD2 GTF2IRD2B	2.76e-04	19	45	2	30228200
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	NDST1 CPLANE1 DNAH11	3.00e-04	100	45	3	25807483
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF27 PRAMEF15	3.06e-04	20	45	2	26694250
Pubmed	Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules.	PPP3CA PPP3CB	3.06e-04	20	45	2	21421818
Pubmed	Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation.	PPP3CA PPP3CB	3.38e-04	21	45	2	31696965
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF27 PRAMEF15	3.72e-04	22	45	2	31729367
Pubmed	Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.	ABCA5 ABCC10	3.72e-04	22	45	2	8894702
Pubmed	Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.	PPP3CA PPP3CB	4.07e-04	23	45	2	20379146
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF27 PRAMEF15	4.82e-04	25	45	2	37451217
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF27 PRAMEF15	6.06e-04	28	45	2	25089626
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	RNF213 NDST1 DPY19L1 LRP1B DSE TXNDC11 SYMPK	8.29e-04	1201	45	7	35696571
Pubmed	Joubert Syndrome	TTC21B CPLANE1	8.94e-04	34	45	2	20301500
Pubmed	Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract.	RGS9 CNGA1	8.94e-04	34	45	2	33500475
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF27 PRAMEF15	9.48e-04	35	45	2	19389355
Pubmed	Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.	PPP3CA PPP3CB	1.12e-03	38	45	2	12482669
Pubmed	Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.	PPP3CB SYMPK	1.18e-03	39	45	2	22802532
Cytoband	1p36.21	PRAMEF9 PRAMEF15	1.77e-03	63	45	2	1p36.21
Cytoband	7q11.23	GTF2IRD2 GTF2IRD2B	4.12e-03	97	45	2	7q11.23
Cytoband	Ensembl 112 genes in cytogenetic band chr17q24	RGS9 ABCA5	4.21e-03	98	45	2	chr17q24
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	WRAP73 PRAMEF9 PRAMEF27 PRAMEF15	4.42e-03	681	45	4	chr1p36
GeneFamily	PRAME family	PRAMEF9 PRAMEF27 PRAMEF15	5.89e-06	24	27	3	686
GeneFamily	Cyclic nucleotide gated channels	CNGA1 CNGB3	9.59e-05	10	27	2	250
GeneFamily	Protein phosphatase catalytic subunits\|EF-hand domain containing	PPP3CA PPP3CB	1.66e-04	13	27	2	693
GeneFamily	Sulfotransferases, membrane bound	NDST1 GAL3ST1	1.38e-03	37	27	2	763
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NEB ABCA5 LRP1B CNGA1	2.15e-05	162	45	4	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	droplet-Lung-nan-18m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBR3 DNASE1 ABCC10 TXNDC11	2.20e-05	163	45	4	5efecdd8a069a822bc9d35b407092925a865e629
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBR3 DNASE1 ABCC10 TXNDC11	2.20e-05	163	45	4	0d94a427f86e62aba12c397c6d7b8cd297f3a0e5
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UBR3 DNASE1 ABCC10 TXNDC11	2.26e-05	164	45	4	b92e7c91910d518627376166c6ea9ed333b3d07e
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-plasma_cell-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UBR3 DNASE1 ABCC10 TXNDC11	2.26e-05	164	45	4	a1e43c6b3e2553f5604100db6e92bf244b70c36d
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TRPM1 LRP1B CNGA1 INPP4B	2.48e-05	168	45	4	68ee3b3b012b56584e313813feb16e632e3f72d2
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l5\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TRPM1 LRP1B CNGA1 INPP4B	2.60e-05	170	45	4	67e78e3c1d4cd3c6eaa5d0a9785b6cd8a3b08039
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-5\|TCGA-Skin / Sample_Type by Project: Shred V9	PCNX2 TSPAN11 LRP1B GAL3ST1	3.11e-05	178	45	4	ad5cd505ca1cef8ac29b2af7e2c3e01ebc140c14
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPP3CA ABCA5 INPP4B DNAH11	3.11e-05	178	45	4	51d2188406f04329311b2efd1108fc36617a860e
ToppCell	Adult-Epithelial-club_cell-D122\|Adult / Lineage, Cell type, age group and donor	TSPAN11 LRP1B UTY INPP4B	3.11e-05	178	45	4	35a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RNF213 NEB DSE OASL	3.39e-05	182	45	4	4234d0cc57b5266a5e03133c75c7918abe48465e
ToppCell	COVID-19_Severe-CD8+_T_activated\|World / disease group, cell group and cell class	RNF213 RGS9 UTY OASL	4.26e-05	193	45	4	ddc1db516568e03be8e82b2ca770c67756418185
ToppCell	PBMC-Mild\|PBMC / Compartment, Disease Groups and Clusters	RNF213 DSE TXNDC11 OASL	4.35e-05	194	45	4	d1366b169d14011194e61d16b6b0953349febc78
Drug	Trichlorfon [52-68-6]; Down 200; 15.6uM; HL60; HT_HG-U133A	PCNX2 PPP3CB DSE SYMPK NUDT2 OASL	1.87e-06	198	43	6	1839_DN
Disease	Disorder of eye	TTC21B RGS9 TRPM1 CPLANE1 CNGA1 CNGB3	5.42e-07	212	42	6	C0015397
Disease	focal segmental glomerulosclerosis (is_marker_for)	PPP3CA PPP3CB	5.51e-05	8	42	2	DOID:1312 (is_marker_for)
Disease	Familial aplasia of the vermis	TTC21B CPLANE1	3.70e-04	20	42	2	cv:C0431399
Disease	Ciliopathies	TTC21B CPLANE1 DNAH11	5.21e-04	110	42	3	C4277690
Disease	Hepatic Form of Wilson Disease	PPP3CA PPP3CB	5.35e-04	24	42	2	C1527352
Disease	Hepatolenticular Degeneration	PPP3CA PPP3CB	5.35e-04	24	42	2	C0019202
Disease	visuospatial function measurement	WRAP73 INPP4B	6.29e-04	26	42	2	EFO_0803533
Disease	colonic neoplasm	CNGA1 SYMPK	1.57e-03	41	42	2	EFO_0004288
Disease	rectum cancer	LRP1B INPP4B	1.64e-03	42	42	2	EFO_1000657
Disease	schizophrenia (is_marker_for)	PPP3CA PPP3CB	1.80e-03	44	42	2	DOID:5419 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LCYDLAELLLKLKWY	TTC21B	791	Q7Z4L5
LQCVLWIFLLQYYEK	ABCA5	1216	Q8WWZ7
EYLICEDYKLFWVAP	BUB1B	771	O60566
LCAWVINIIKFYEVY	DNAH11	3296	Q96DT5
VIYWLAEVKDYDVEI	NUDT2	91	P50583
DRYALDCQEKAYWLV	RGS9	176	O75916
WAVLCYYAEDLRLKL	ANO7	176	Q6IWH7
LRVIKYLDAACVYLW	ABCC10	496	Q5T3U5
ALDLVNKLVYWVDLY	LRP1B	376	Q9NZR2
WYEQLYPLILTLKDC	INPP4B	576	O15327
ERLYVWLQCFEKYIL	PCNX2	1181	A6NKB5
WLQCFEKYILYPALI	PCNX2	1186	A6NKB5
LHIDLWKCYLSYVRE	CSTF3	96	Q12996
KLKVNYYILEESWCV	DPY19L1	606	Q2PZI1
IIYENILKYVNLDAW	NDST1	136	P52848
TLDEYLTYLLLWVKQ	PRAMEF15	161	P0DUQ1
YAVLLIDSCILLWLY	DSE	936	Q9UL01
ELCLEYKIYDLQLWN	KNTC1	1966	P50748
LLLEYEVICIYWTKY	OASL	266	Q15646
LCWELEDVLYFKLNA	GAL3ST1	266	Q99999
GCIFLWEYLELKNIL	CPLANE1	136	Q9H799
IDALYDVYLDVQEKW	DNASE1	166	P24855
RLIKFIYNICCYWEI	ATG9A	146	Q7Z3C6
CIILQLYPWKYISRE	ASNSD1	191	Q9NWL6
YDLIRAFLAKLCLWE	GTF2IRD2	781	Q86UP8
YDLIRAFLAKLCLWE	GTF2IRD2B	781	Q6EKJ0
IECVLYLWVLKILYP	PPP3CB	136	P16298
SIECVLYLWALKILY	PPP3CA	126	Q08209
PYLVCEETAKYLILW	CDC37L1	186	Q7L3B6
EELLVYDICKYRWCE	PRIMPOL	406	Q96LW4
REDLFCYWEKLVYLL	GARIN3	161	Q8TC56
LTACQYKLAVERYEW	UTY	1191	O14607
ALLYVKCRLNVLLWY	SIGIRR	136	Q6IA17
TLDEYLTYLLLWVKQ	PRAMEF27	161	A3QJZ7
WDTCLEYKILLYSLD	WRAP73	196	Q9P2S5
WLILDYVSDIVYLID	CNGA1	196	P29973
HYWLIADIICDIIYL	CNGB3	251	Q9NQW8
KDYLEELWVQAQYIT	RNF213	3716	Q63HN8
TLDEYLTYLLLWVKQ	PRAMEF9	161	P0DUQ2
TEQDDWLIIYLKYLL	TSPAN11	6	A1L157
LYLYDVEVKCWEQLL	WDR6	371	Q9NNW5
PWTEETVKQCLYLYL	SYMPK	781	Q92797
YCVDIIFWYIRVLDI	TRPM1	931	Q7Z4N2
WEVVLQKQDVLLLYY	TXNDC11	701	Q6PKC3
YICKERYKVLEQQWI	UBR3	1856	Q6ZT12
ISDVCYKRDWYDLIA	NEB	1291	P20929