Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domain-

RASA4 RASA4B

3.57e-0536524.10.1130.10
DomainBTK

RASA4 RASA4B

4.23e-049652SM00107
DomainZnf_Btk_motif

RASA4 RASA4B

4.23e-049652IPR001562
DomainBTK

RASA4 RASA4B

4.23e-049652PF00779
DomainZF_BTK

RASA4 RASA4B

4.23e-049652PS51113
DomainKelch_2

HCFC2 HCFC1

9.08e-0413652IPR011498
DomainKelch_2

HCFC2 HCFC1

9.08e-0413652PF07646
DomainRasGAP

RASA4 RASA4B

1.06e-0314652SM00323
DomainDynein_heavy_chain_D4_dom

DNAH3 DNAH6

1.06e-0314652IPR024317
DomainDynein_HC_stalk

DNAH3 DNAH6

1.06e-0314652IPR024743
DomainDynein_heavy_dom-2

DNAH3 DNAH6

1.06e-0314652IPR013602
DomainDHC_N2

DNAH3 DNAH6

1.06e-0314652PF08393
DomainMT

DNAH3 DNAH6

1.06e-0314652PF12777
DomainAAA_8

DNAH3 DNAH6

1.06e-0314652PF12780
DomainATPase_dyneun-rel_AAA

DNAH3 DNAH6

1.06e-0314652IPR011704
DomainRasGAP_CS

RASA4 RASA4B

1.06e-0314652IPR023152
DomainAAA_5

DNAH3 DNAH6

1.06e-0314652PF07728
DomainPH

RASA4 TBC1D2B RASA4B APBB1IP ARAP1

1.20e-03229655PF00169
DomainDHC_fam

DNAH3 DNAH6

1.22e-0315652IPR026983
DomainRasGAP

RASA4 RASA4B

1.22e-0315652PF00616
DomainRAS_GTPASE_ACTIV_1

RASA4 RASA4B

1.22e-0315652PS00509
DomainRAS_GTPASE_ACTIV_2

RASA4 RASA4B

1.22e-0315652PS50018
DomainDynein_heavy_dom

DNAH3 DNAH6

1.22e-0315652IPR004273
DomainDynein_heavy

DNAH3 DNAH6

1.22e-0315652PF03028
DomainN2O_reductase_N

PEX7 DCAF7

1.22e-0315652IPR011045
Domain-

RASA4 RASA4B

1.39e-03166521.10.506.10
DomainRasGAP_dom

RASA4 RASA4B

1.76e-0318652IPR001936
DomainPH

RASA4 TBC1D2B RASA4B APBB1IP ARAP1

2.81e-03278655SM00233
DomainPH_DOMAIN

RASA4 TBC1D2B RASA4B APBB1IP ARAP1

2.85e-03279655PS50003
DomainActinin_actin-bd_CS

SYNE1 ACTN4

2.88e-0323652IPR001589
DomainSpectrin

SYNE1 ACTN4

2.88e-0323652PF00435
DomainACTININ_2

SYNE1 ACTN4

2.88e-0323652PS00020
DomainACTININ_1

SYNE1 ACTN4

2.88e-0323652PS00019
DomainPH_domain

RASA4 TBC1D2B RASA4B APBB1IP ARAP1

2.90e-03280655IPR001849
DomainRho_GTPase_activation_prot

RASA4 RASA4B ARAP1

3.58e-0388653IPR008936
Domain-

HCFC2 HCFC1

3.96e-03276522.130.10.80
DomainSpectrin_repeat

SYNE1 ACTN4

4.56e-0329652IPR002017
DomainSpectrin/alpha-actinin

SYNE1 ACTN4

5.53e-0332652IPR018159
DomainSPEC

SYNE1 ACTN4

5.53e-0332652SM00150
DomainGal_Oxidase_b-propeller

HCFC2 HCFC1

6.23e-0334652IPR015916
DomainRA

APBB1IP ARAP1

6.96e-0336652PF00788
Pubmed

CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.

RASA4 RASA4B

3.55e-06266211448776
Pubmed

A genetic basis for corneal sensitivity to ultraviolet light among recombinant SWXJ inbred strains of mice.

AOX1 ALDH3A2

3.55e-0626629192162
Pubmed

An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.

RASA4 RASA4B

3.55e-06266216041389
Pubmed

CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.

RASA4 RASA4B

1.06e-05366225637021
Pubmed

Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.

RASA4 RASA4B

2.12e-05466221460216
Pubmed

PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells.

PKM AURKB

2.12e-05466225412762
Pubmed

Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.

RASA4 RASA4B

2.12e-05466216234249
Pubmed

Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes.

DNAH3 DNAH6

2.12e-05466211175280
Pubmed

Two chemotactic factors, C5a and MIP-1alpha, dramatically alter the mortality from zymosan-induced multiple organ dysfunction syndrome (MODS): C5a contributes to MODS while MIP-1alpha has a protective role.

C5 CCL18

3.53e-0556629047380
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

CEP68 RASA4 SFI1 ZNF292

4.89e-051056649628581
Pubmed

Genotype and phenotype of 101 dutch patients with congenital stationary night blindness.

CACNA1F GPR179

5.29e-05666223714322
Pubmed

Cep44 functions in centrosome cohesion by stabilizing rootletin.

CEP68 CEP44

5.29e-05666231974111
Pubmed

Elucidation of the early events contributing to zymosan-induced multiple organ dysfunction syndrome using MIP-1alpha, C3 knockout, and C5-deficient mice.

C5 CCL18

5.29e-05666210565608
Pubmed

Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2.

HCFC2 HCFC1

9.86e-05866232479599
Pubmed

Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.

HCFC2 HCFC1

9.86e-05866231804488
Pubmed

Comparative genome mapping in the sequence-based era: early experience with human chromosome 7.

RASA4 RASA4B

9.86e-05866210810084
Pubmed

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.

HCFC2 HCFC1

1.27e-04966215199122
Pubmed

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.

RASA4 UBE3B APBB1IP

1.35e-045266330655611
Pubmed

A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16.

KANSL1L HCFC1

1.58e-041066216227571
Pubmed

The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors.

CACNA1F GPR179

1.93e-041166228262416
Pubmed

A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.

HCFC2 ALDH3A2 HCFC1

2.17e-046166320305087
Pubmed

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.

ATP6V0A1 NPEPPS PKM ACTN4

2.86e-0416666427160897
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH3 DNAH6

3.18e-04146629373155
Pubmed

LHPP impedes energy metabolism by inducing ubiquitin-mediated degradation of PKM2 in glioblastoma.

PKM ACTN4

4.18e-041666233948363
Pubmed

Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins.

SFI1 AURKB

4.18e-041666229764992
Pubmed

Genetic influences on the end-stage effector phase of arthritis.

NCF2 C5

4.18e-041666211489951
Pubmed

Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.

NCF2 C5 CCL18 MUC2

6.23e-0420466420503287
Pubmed

Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.

NCF2 C5 CCL18 MUC2

6.35e-0420566419258923
Pubmed

Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.

NCF2 C5 CCL18 MUC2

6.58e-0420766417703412
Pubmed

Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation.

METTL9 CCL18

6.59e-042066221784977
Pubmed

Proteomic identification of the TRAF6 regulation of vacuolar ATPase for osteoclast function.

PKM ACTN4

7.28e-042166216196101
Pubmed

Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus.

FANCC AURKB

7.28e-042166224483844
Pubmed

Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved.

NPEPPS PKM ALDH3A2 TXNDC11

7.85e-0421766430619736
Pubmed

Structural basis for activity regulation of MLL family methyltransferases.

HCFC2 HCFC1

7.99e-042266226886794
Pubmed

Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity.

CEP68 DCAF7

8.75e-042366222792062
Pubmed

New genetic associations detected in a host response study to hepatitis B vaccine.

CD82 METTL9 NCF2 C5 CCL18 ALDH3A2 KLRB1

9.46e-0482466720237496
Pubmed

Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

CEP44 SYNE1 DNAH6

9.80e-0410266311214970
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

CD82 SLC44A1 PAN2 PHTF2 ACTN4 ACCSL UBE2Q2 RNF215

1.01e-03108466811544199
Pubmed

Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.

MRC1 SMYD4 C5

1.01e-0310366311752456
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

KANSL1L DNAH3 SYNE1 ZNF292

1.02e-0323366437704626
Pubmed

Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.

SYNE1 AURKB

1.03e-032566238877142
Pubmed

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.

NPEPPS PKM ACTN4 ALDH3A2 DCAF7

1.20e-0341866532552912
Pubmed

Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.

TBC1D10B TBC1D2B

1.21e-032766222354992
Pubmed

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.

PDHA2 PKM ALDH3A2

1.35e-0311466328245920
Pubmed

Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.

NPEPPS PKM ACTN4 HCFC1

1.49e-0325866421081666
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

FANCC SYNE1 PKM ALDH3A2 HCFC1 ARAP1 AURKB DCAF7

1.51e-03115566820360068
Pubmed

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.

NPEPPS PKM ACTN4 TRMT1L HCFC1

1.67e-0345166536168627
Pubmed

HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages.

ACTN4 AURKB

1.70e-033266227114546
Pubmed

A catalogue of putative HIV-1 protease host cell substrates.

NPEPPS PKM ZNF292

1.72e-0312466322944692
Pubmed

Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.

RASA4 RASA4B AURKB

1.80e-0312666324319055
Pubmed

SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.

SYNE1 PKM ACTN4 ALDH3A2 AURKB

1.88e-0346366534901782
GeneFamilyPleckstrin homology domain containing|SH2 domain containing|C2 and RasGAP domain containing

RASA4 RASA4B

2.57e-0410442830
GeneFamilyDyneins, axonemal

DNAH3 DNAH6

7.69e-0417442536
GeneFamilyADAM metallopeptidase domain containing|CD molecules

MPL MRC1 CD82 SLC44A1 KLRB1

2.59e-03394445471
CoexpressionGSE9650_NAIVE_VS_MEMORY_CD8_TCELL_UP

SLC44A1 METTL9 PAN2 PHTF2 EXT1 ZNF292

1.14e-05200666M5831
CoexpressionKAECH_NAIVE_VS_MEMORY_CD8_TCELL_UP

METTL9 PAN2 PHTF2 NCF2 EXT1 ZNF292

1.14e-05200666M3020
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC1 HEATR4 C5 UBE2Q2 ARAP1

4.94e-06167665881f64db8dea3faa7588bf04d87c20924a4e5952
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FANCC HEATR4 WDR90 C5 AURKB

9.72e-06192665d6f656be2698bd215717d35f4e7ab727c08c61e0
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

DNAH3 ZCWPW2 SYNE1 DNAH6 AURKB

1.07e-05196665af4cdc61830685a888a1209826c23bcf54a43084
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

DNAH3 ZCWPW2 SYNE1 DNAH6 AURKB

1.07e-051966656d02d494196e3f857d53eea46d9419690d43beca
ToppCell3'_v3-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|bone_marrow / Manually curated celltypes from each tissue

SLC44A1 PKM NCF2 PRR11 AURKB

1.16e-05199665961666a677589c65f733f7262822689101d39ae3
ToppCellCOVID-19-Myeloid-MoAM3,_VCAN|Myeloid / Condition, Lineage and Cell class

MRC1 SLC44A1 METTL9 PKM NCF2

1.16e-0519966580f70c53e892fb692ef655662732e16e2c03ac8e
ToppCelldroplet-Heart-4Chambers-18m-Hematologic-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MPL CACNA1F WDR90

3.82e-05446634c7d5b655fa27a1377018358e24a1e7aadae024d
ToppCell10x5'-bone_marrow-Myeloid_Monocytic-Cycling_mono|bone_marrow / Manually curated celltypes from each tissue

SLC44A1 ATP6V0A1 PKM NCF2

6.91e-05148664de35eeefad0e27a0d127e2e4bedead2bddb75152
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

NPEPPS SYNE1 ACTN4 KLRB1

7.47e-051516640cc2f4aec3dae4603fa831f22c40f897e68b34e2
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

NPEPPS SYNE1 ACTN4 KLRB1

7.47e-05151664b545823113a3450c5f841f7de48bf0937593544f
ToppCellNS-moderate-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 CNIH2 WDR90 DNAH6

8.69e-05157664410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MRC1 CACNA1F NCF2 APBB1IP

9.58e-051616645a8698790f9aba796dd2b64af419055c60bd7de8
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_4|356C / Donor, Lineage, Cell class and subclass (all cells)

GPLD1 DNAH3 PEX7 CCL18

9.81e-051626647d43d59531cbefe3ac94953b7faf7156b2a31441
ToppCelllung-Club_Cells|lung / shred on tissue and cell subclass

MRC1 CD82 SLITRK6 MUC2

1.03e-04164664b12cacd499b18b96120ca6d14646aebeaed41d10
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5|TCGA-Ovary / Sample_Type by Project: Shred V9

MPL KANSL1L UBE3B PAN2

1.08e-0416666432d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Hematologic-proerythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

METTL9 SYNE1 PKM NCF2

1.08e-04166664a1211afc1197d078eb3db0d0f788ecaf4419aa5b
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 CCL18 PRR11

1.12e-0463663d8308a11cc01252b678f2e3247ee3a028221e04c
ToppCelldroplet-Marrow-nan-21m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

METTL9 SYNE1 PKM NCF2

1.35e-04176664f7d8eb90489a6d22240179abeb0aa16ac24615d3
ToppCelldroplet-Marrow-nan-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MPL METTL9 PKM NCF2

1.38e-041776645d70fe2b0592362d664b3b4c84eb450ec2335957
ToppCelldroplet-Marrow-nan-18m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MPL METTL9 PKM NCF2

1.38e-0417766448bcf603ec9593eedd81f3831cf9fde89fad368f
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 TBC1D2B ACTN4 KLRB1

1.50e-0418166412ff56fa2949c8d53360cdf2cacfd326e65b54aa
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-actively_dividing_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MPL CNIH2 PRR11 AURKB

1.54e-04182664bc6a120dedc813c58baac1428c39851a07b71ba7
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-keratinocyte_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MPL CNIH2 PRR11 AURKB

1.54e-041826640fc45214f0b0766f69be6eff69cc4bec574023aa
ToppCell3'_v3-bone_marrow-Myeloid_Monocytic-Cycling_mono|bone_marrow / Manually curated celltypes from each tissue

SLC44A1 METTL9 PKM NCF2

1.57e-04183664f10e72a2e2e6cdc1984f469a60244e5fd8a10095
ToppCellwk_20-22-Hematologic_Lymphocytic-B-CD5+_CCL22+_mature_B|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CD82 RASA4 PKM RASA4B

1.60e-041846645bb775253a10a14360b06a46aba46d162a9bd1f8
ToppCellPCW_05-06-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_migrating_dendritic_(5)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MRC1 NCF2 CCL18 APBB1IP

1.67e-0418666473185d48c874e18dd2e2eeea67c32d3182ea88a5
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|bone_marrow / Manually curated celltypes from each tissue

SLC44A1 PKM PRR11 AURKB

1.67e-04186664e82d5e7a976b9cfa2b4640c7a7cd1cfea19c4806
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.4.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT85 AOX1 KLRB1 ABCA8

1.67e-0418666407d94d5d1c2fe7bb909a07ca81058a0eabc65c60
ToppCellPCW_05-06-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage2_(0)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MRC1 NCF2 CCL18 APBB1IP

1.70e-04187664bde6b90955423eab6a91a0abe75d0a95a1f5330a
ToppCellCOPD-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

ZCWPW2 SYNE1 KLRB1 AURKB

1.74e-04188664186fe1ea328c942910190a4240262c0d8642ea3b
ToppCellIPF-Lymphoid-T_Regulatory|Lymphoid / Disease state, Lineage and Cell class

PKM PHTF2 EXT1 ZNF292

1.77e-041896647a260485c2a7c743c14d048e5e480ae0a9b8e32c
ToppCellMacrophages-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

MRC1 NCF2 CCL18 ARAP1

1.77e-04189664c05b4b565c0ce56dbb45fc9503654a2ec1a7e1e9
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_immature_monocyte2_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MRC1 NCF2 CCL18 APBB1IP

1.81e-04190664e5625feb21915d4545cfad2659745ef180efcb1f
ToppCellILEUM-non-inflamed-(1)_T_cell-(1)_Th17_Trm|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

CD82 METTL9 PHTF2 KLRB1

1.81e-04190664693b223f6b94a46d935fbcb02d7a27340ce43154
ToppCellH1299-infected|H1299 / Cell line, Condition and Strain

WDR90 PRR11 AURKB ZNF292

1.88e-041926649cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CD82 SLC44A1 PKM ELF5

1.96e-04194664d602a0cdb69cd5a3e9ef61ddbab8d920557dd73e
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 SYNE1 WDR90 DNAH6

1.96e-041946644a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

DNAH3 ZCWPW2 SYNE1 DNAH6

2.00e-04195664fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

DNAH3 ZCWPW2 SYNE1 DNAH6

2.00e-04195664eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellBronchial_Biopsy-Immune-Luminal_Macrophages|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

MRC1 CD82 NCF2 CCL18

2.00e-041956646800c17026ec6c56132bf4664b8fcd74d7836579
ToppCelldistal-Hematologic-Interstitial_Macrophage-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MRC1 ATP6V0A1 NCF2 CCL18

2.04e-04196664e4f40274df940e0996c555082f2bb4f99e5b0881
ToppCellCOVID-19-lung-Macrophage_metabolically_active|lung / Disease (COVID-19 only), tissue and cell type

MRC1 NCF2 CCL18 APBB1IP

2.04e-04196664a753d76d764c181eecb0e17a794a2e7d0ff70136
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_3|COVID-19_Mild / Disease condition and Cell class

CD82 METTL9 PKM NCF2

2.04e-04196664f245e929a286cb097130572e1027b4f01be8b04d
ToppCellCOVID-19-lung-Macrophage_metabolically_active|COVID-19 / Disease (COVID-19 only), tissue and cell type

MRC1 NCF2 CCL18 APBB1IP

2.04e-041966641b7928f4eee94d4bb6ea410bab68a471dba12979
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 SYNE1 WDR90 DNAH6

2.08e-0419766474a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CACNA1F SMYD4 ELF5 C5

2.12e-04198664285f729140b1df029c24f6ca1d2438470ac51794
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 NCF2 KLRB1 APBB1IP

2.12e-0419866441e8a7894f52f3a5f8f24575b3f6e205429489b2
ToppCell3'_v3-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-1|bone_marrow / Manually curated celltypes from each tissue

SLC44A1 PKM PRR11 AURKB

2.12e-041986645c92687b853ebb00960adbef6552f9d460bc6886
ToppCellCOVID-19-kidney-Macrophages|kidney / Disease (COVID-19 only), tissue and cell type

MRC1 NCF2 CCL18 APBB1IP

2.12e-04198664161324541fe5da5cbb58142ea94fefd39b7dfb04
ToppCell5'-GW_trimst-1.5-SmallIntestine-Hematopoietic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 NCF2 KLRB1 APBB1IP

2.12e-0419866423314bed02edadccdc5da4fa153142a25e4a440e
ToppCellSevere_COVID-19-Myeloid-MoAM3|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

MRC1 SLC44A1 PKM NCF2

2.16e-0419966430523cf08815ca214877e33a2c52197ff8318557
ToppCell18-Airway-Mesenchymal-Mesenchyme_RSPO2+|Airway / Age, Tissue, Lineage and Cell class

SLC44A1 PRR11 ABCA8 AURKB

2.16e-041996647ac35e8f45dcdc702422dabd8f3e4d03e2bf61af
ToppCellFLU-Healthy-4|Healthy / Virus stimulation, Condition and Cluster

CD82 PKM SFI1 ZNF292

2.16e-0419966440061131e35131873192ca65c0e731a7b3045636
ToppCellBAL-Severe-Myeloid-MoAM-MoAM3|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

MRC1 SLC44A1 PKM NCF2

2.16e-04199664105709b97c55826a852aed27658e3b4af1738c8a
ToppCellCOVID-19-Myeloid-MoAM3,_VCAN|COVID-19 / Condition, Lineage and Cell class

MRC1 SLC44A1 PKM NCF2

2.16e-04199664aba0b833e44fe42625fac91466f6ebaa8e786d3b
ToppCellBAL-Severe-Myeloid-MoAM-MoAM3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MRC1 SLC44A1 PKM NCF2

2.16e-041996640892957a49304ce4b6daa3657d76d8365ce0dd19
ToppCellBAL-Severe-Myeloid-MoAM-MoAM3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MRC1 SLC44A1 PKM NCF2

2.16e-04199664b2dc3d0af6ecd3ab01779aaa1f061cb0f941cae8
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SYNE1 AOX1 SLITRK6 ABCA8

2.16e-0419966430d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MRC1 NCF2 CCL18 ARAP1

2.16e-04199664667b8b47a5b388506e3177b46747267fad8024f6
ToppCellBAL-Severe-Myeloid-MoAM-MoAM3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MRC1 SLC44A1 PKM NCF2

2.16e-04199664961ad44199871be8e09d31904d383edc865ba262
ToppCellCOVID-19-lung|COVID-19 / Disease (COVID-19 only), tissue and cell type

MRC1 TBC1D2B APBB1IP ARAP1

2.16e-04199664155b03b859157013e9142e9248551369127d9204
ToppCellBAL-Severe-cDC_0|Severe / Compartment, Disease Groups and Clusters

MRC1 NCF2 CCL18 ALDH3A2

2.16e-04199664d39be8b173156bf87baddd3caed4b35597c53ea1
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Dividing_Basal|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CNIH2 ELF5 PRR11 AURKB

2.16e-04199664f0c289523957258d16135c04679db379d43d28d9
ToppCellParenchymal-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 NCF2 CCL18 AURKB

2.20e-042006640cf7208eab0dc58fbea35e256c5cb55cdd4a4928
ToppCellParenchyma_COVID-19-Immune-TX-MoAM-2|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

MRC1 NCF2 CCL18 APBB1IP

2.20e-0420066433c5615cbedb9e14f4433169babd3a3a51f69b4c
ToppCellBronchial|World / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 NCF2 CCL18 APBB1IP

2.20e-0420066409e5ca0d5073bbf006588b0524bf1be6468c812c
ToppCellBronchus_Control_(B.)-Epithelial-TX-Ciliated|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

DNAH3 SYNE1 WDR90 DNAH6

2.20e-042006646a2ccc71a0cbe04a542c379b28b5006de53981c3
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-Myofibroblasts|Fibroblasts / Location, Cell class and cell subclass

SLC44A1 METTL9 PKM EXT1

2.20e-04200664eabb7d4aa92ace7d970bcd3fae2c7cb5400a43b4
ToppCellBiopsy_IPF-Immune|Biopsy_IPF / Sample group, Lineage and Cell type

MRC1 NCF2 CCL18 APBB1IP

2.20e-0420066431067dcf63030144679fca20fa41d665cb0035b7
ToppCellParenchyma_COVID-19-Immune-TX|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

MRC1 NCF2 CCL18 APBB1IP

2.20e-04200664fe27d56a05151049a64e35db5a144ff7952e6902
ToppCellBiopsy_Other_PF-Immune|Biopsy_Other_PF / Sample group, Lineage and Cell type

MRC1 NCF2 CCL18 APBB1IP

2.20e-0420066478b35f7afe4a3ebacf115c6d9c873e697bcbd2df
ToppCellBiopsy_Control_(H.)-Immune|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

MRC1 NCF2 CCL18 APBB1IP

2.20e-04200664e1d50556ca116ef4b65ec29ab2ef7341f0d21451
ToppCellTransverse-Dendritic_cell-cycling_DCs|Transverse / Region, Cell class and subclass

MRC1 NCF2 PRR11 AURKB

2.20e-04200664f588d8889f351c797963616a3575fa43efd46b9a
ToppCellTracheal-NucSeq-Immune_Myeloid-Monocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 NCF2 APBB1IP ARAP1

2.20e-0420066448ce43a27e78b2883e588e1a63fa5352c2deeeb7
ToppCellTransverse-(5)_Dendritic_cell-(52)_cycling_DCs|Transverse / shred on region, Cell_type, and subtype

MRC1 NCF2 PRR11 AURKB

2.20e-0420066451e643d48b5e97a0e117b578a6ea7d429c6cdd1e
ToppCellSubstantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Igfbp2)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

KY DNAH6 GPR179

2.46e-048266389aff8676f98e062d0e69b38c7184e51aa1a915e
ToppCellSubstantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Igfbp2)--|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

KY DNAH6 GPR179

2.46e-04826636875a10abf1221b3dfd954c319b5e8e12fac1ff2
ToppCellSubstantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Igfbp2)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

KY DNAH6 GPR179

2.46e-0482663259bb4ae0373d8352cb1c3bff08f66b89a298440
Diseasecomplement C5B-C6 complex measurement

NPEPPS C5

1.34e-053632EFO_0020279
DiseaseX-Linked Csnb

CACNA1F GPR179

2.92e-0412632C3711543
DiseaseNight blindness, congenital stationary, type 1

CACNA1F GPR179

2.92e-0412632C3501847
DiseaseNight Blindness, Congenital Stationary, Type 1A

CACNA1F GPR179

2.92e-0412632C3495587
DiseaseNIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2B (disorder)

CACNA1F GPR179

2.92e-0412632C1864877
DiseaseNIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A

CACNA1F GPR179

2.92e-0412632C1848172
DiseaseNIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B

CACNA1F GPR179

2.92e-0412632C1850362
DiseaseCone-rod synaptic disorder, congenital nonprogressive

CACNA1F GPR179

3.45e-0413632C4041558
Diseasecongenital heart disease (implicated_via_orthology)

SMYD4 HCFC2 HCFC1

4.40e-0469633DOID:1682 (implicated_via_orthology)
DiseaseNight blindness, congenital stationary

CACNA1F GPR179

5.98e-0417632C0339535
Diseasedisease of metabolism (implicated_via_orthology)

PDHA2 PKM

9.18e-0421632DOID:0014667 (implicated_via_orthology)
Diseasegestational diabetes

SLITRK6 ARAP1

1.10e-0323632EFO_0004593
Diseaseatrial fibrillation

FANCC CEP68 EXT1 HCFC2 ZNF292

1.18e-03371635EFO_0000275
DiseaseEndogenous Hyperinsulinism

FANCC MRC1

1.41e-0326632C1257963
DiseaseExogenous Hyperinsulinism

FANCC MRC1

1.41e-0326632C1257964
DiseaseCompensatory Hyperinsulinemia

FANCC MRC1

1.41e-0326632C1257965
DiseaseHyperinsulinism

FANCC MRC1

1.64e-0328632C0020459

Protein segments in the cluster

PeptideGeneStartEntry
CQLLQNTEWIDKVYL

ACCSL

436

Q4AC99
CCQLEELICWLYNVA

CEP68

631

Q76N32
IKYLCCDDTRTLNQW

APBB1IP

396

Q7Z5R6
VNTRCQKICDQWDAL

ACTN4

491

O43707
FAEWKIQIVCDILNC

CEP44

101

Q9C0F1
YILCEASLQNQIVWK

ALDH3A2

246

P51648
NKELCCLVYTSWQIP

CCL18

26

P55774
QIYDNKSCWTVACQK

DISP1

676

Q96F81
PDWIAICYNNCLEIL

DCAF7

326

P61962
EWLQFCCDQYKLDTN

ELF5

71

Q9UKW6
LQDAWDYVQAQVKCC

CD82

136

P27701
QEINAKNLIQCWREC

AOX1

966

Q06278
AYLQCKCVNELNQWL

RASA4

651

O43374
AYLQCKCVNELNQWL

RASA4B

651

C9J798
WLTQIQEYANKVLLC

CACNA1F

556

O60840
AWNNQVCCKDLWYLE

HCFC1

346

P51610
LDQNTQAWCDTCEKY

PAN2

711

Q504Q3
VQLQNCKWYQENALL

KANSL1L

166

A0AUZ9
NSQVCCKDLWYLDTE

HCFC2

341

Q9Y5Z7
QVKNYCLTLWCENTV

NCF2

416

P19878
LCQQQETICIWENKD

GPR179

1866

Q6PRD1
LETKWQFYQNQRCCE

KRT85

151

P78386
VFNYLVCCANTKVNW

KY

551

Q8NBH2
ECLKNVNKCWFLSYI

SPINK8

41

P0C7L1
WIDCSTKQQENVYLA

KIAA1109

541

Q2LD37
NSCWCPCYLQELEIQ

PLSCR5

141

A0PG75
AYAALCAQQNICLDW

MUC2

4736

Q02817
ILSCDWCKYNENLLV

PEX7

201

O00628
WYVCNREKLCESLQA

METTL9

56

Q9H1A3
KCDENILWLDYKNIC

PKM

151

P14618
CQRWVPCKQYCLEVQ

NALF2

306

O75949
AQYRQSLIECWIQDC

DNAH6

3011

Q9C0G6
KSQYCAQIIVLWNCD

EXT1

506

Q16394
YRVQCQNQWLAECKD

DNAH3

3016

Q8TD57
CNSLLWLVENYQLDN

C5

1101

P01031
VELNSCQWKNRIVAC

HEATR4

636

Q86WZ0
LAYDESQKILIWCLC

FANCC

81

Q00597
LWCLEKCLNYLNQNA

SLC44A1

486

Q8WWI5
QCCENILLNAAWLKR

NPEPPS

886

P55786
LWKLPCVFICENNLY

PDHA2

211

P29803
KWENLECVQKLGYIC

MRC1

326

P22897
CKACWKLQQESRYQT

FUT5

351

Q11128
ALLCKCIELWLQYTQ

SFI1

451

A8K8P3
IQCLIGAYDQQIWEK

PHTF2

46

Q8N3S3
KIQYLIHCQWCEERI

TRMT1L

481

Q7Z2T5
KYCSQECLQQAWELY

SMYD4

316

Q8IYR2
ACNCDLLQLKTWLEN

SLITRK6

221

Q9H5Y7
LESWSEYENNVQCLK

SYNE1

7021

Q8NF91
AVCLDYFCNKQWLRV

RNF215

326

Q9Y6U7
ISVCQQTWALLCKNF

ABCA8

6

O94911
KQQWYLCCDTQMELR

ARAP1

1371

Q96P48
DILNYCQKESWCKLA

CNIH2

126

Q6PI25
NEKVDLWCIGVLCYE

AURKB

251

Q96GD4
RQQLKWLICELCSLY

UBE2Q2

96

Q8WVN8
IQFQVLNQSCLCLAW

WDR90

1471

Q96KV7
CQDIYCNLGWTLLAA

GPLD1

506

P80108
CQQLCQTLLEYAEKW

ZNF292

51

O60281
AEQAFWCLVQICDKY

TBC1D10B

461

Q4KMP7
CFTLDLKNVTCQWQQ

MPL

291

P40238
LNYTAENICKWALEN

TXNDC11

336

Q6PKC3
NIDVTQKCLIAEVWC

ATP6V0A1

311

Q93050
IQQIKNILWYCCDFL

UBE3B

131

Q7Z3V4
VQCENENCLKWRLLS

ZCWPW2

31

Q504Y3
WCQNCITQSLEVLKD

PRR11

86

Q96HE9
LQELQQKRWEYCNSL

TBC1D2B

131

Q9UPU7
EEWKCLDLAQQNLYR

ZNF195

16

O14628
LLNCPIYWQQLREKC

KLRB1

91

Q12918