Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane transporter activity

SV2C SLC9A9 CACNG1 TOMM20L CLCNKA SLC30A1 SLC14A2 ABCA7 SLC25A2 SLC25A15

2.46e-0611802810GO:0022857
GeneOntologyMolecularFunctiontransporter activity

SV2C SLC9A9 CACNG1 TOMM20L CLCNKA SLC30A1 SLC14A2 ABCA7 SLC25A2 SLC25A15

5.44e-0612892810GO:0005215
GeneOntologyMolecularFunctionL-ornithine transmembrane transporter activity

SLC25A2 SLC25A15

1.89e-055282GO:0000064
GeneOntologyMolecularFunctionantiporter activity

SLC9A9 SLC30A1 SLC25A2 SLC25A15

3.93e-05138284GO:0015297
GeneOntologyMolecularFunctionL-lysine transmembrane transporter activity

SLC25A2 SLC25A15

6.78e-059282GO:0015189
GeneOntologyMolecularFunctionL-arginine transmembrane transporter activity

SLC25A2 SLC25A15

1.46e-0413282GO:0061459
GeneOntologyMolecularFunctionbasic amino acid transmembrane transporter activity

SLC25A2 SLC25A15

3.55e-0420282GO:0015174
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC9A9 SLC30A1 ABCA7 SLC25A2 SLC25A15

4.75e-04477285GO:0022804
GeneOntologyMolecularFunctionmetal cation:proton antiporter activity

SLC9A9 SLC30A1

6.51e-0427282GO:0051139
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC9A9 SLC30A1 SLC25A2 SLC25A15

7.32e-04296284GO:0015291
GeneOntologyMolecularFunctionmetal cation:monoatomic cation antiporter activity

SLC9A9 SLC30A1

1.65e-0343282GO:0140828
GeneOntologyMolecularFunctioncalcium channel regulator activity

CACNG1 SLC30A1

2.59e-0354282GO:0005246
GeneOntologyMolecularFunctionL-amino acid transmembrane transporter activity

SLC25A2 SLC25A15

4.44e-0371282GO:0015179
GeneOntologyBiologicalProcessmitochondrial L-ornithine transmembrane transport

SLC25A2 SLC25A15

4.95e-063272GO:1990575
GeneOntologyBiologicalProcessL-ornithine transmembrane transport

SLC25A2 SLC25A15

2.47e-056272GO:1903352
GeneOntologyBiologicalProcessornithine transport

SLC25A2 SLC25A15

3.45e-057272GO:0015822
GeneOntologyBiologicalProcessL-lysine transmembrane transport

SLC25A2 SLC25A15

7.38e-0510272GO:1903401
GeneOntologyBiologicalProcessL-lysine transport

SLC25A2 SLC25A15

7.38e-0510272GO:1902022
GeneOntologyBiologicalProcessurea cycle

SLC25A2 SLC25A15

1.28e-0413272GO:0000050
GeneOntologyBiologicalProcessL-arginine transmembrane transport

SLC25A2 SLC25A15

1.71e-0415272GO:1903826
GeneOntologyBiologicalProcessurea metabolic process

SLC25A2 SLC25A15

1.71e-0415272GO:0019627
GeneOntologyBiologicalProcessnitrogen cycle metabolic process

SLC25A2 SLC25A15

1.71e-0415272GO:0071941
GeneOntologyBiologicalProcessbasic amino acid transmembrane transport

SLC25A2 SLC25A15

2.78e-0419272GO:1990822
GeneOntologyBiologicalProcessmitochondrial transmembrane transport

TOMM20L SLC25A2 SLC25A15

3.53e-04106273GO:1990542
GeneOntologyBiologicalProcessbasic amino acid transport

SLC25A2 SLC25A15

3.75e-0422272GO:0015802
GeneOntologyBiologicalProcessregulation of phagocytosis, engulfment

ABCA7 SIGLEC8

4.47e-0424272GO:0060099
GeneOntologyBiologicalProcessregulation of membrane invagination

ABCA7 SIGLEC8

4.86e-0425272GO:1905153
GeneOntologyBiologicalProcessregulation of neurotransmitter transport

SV2C SLC30A1 SYNGR3

8.11e-04141273GO:0051588
GeneOntologyCellularComponentapical plasma membrane

CASR CLCNKA SLC14A2 ABCA7 FRMD1

4.24e-04487285GO:0016324
GeneOntologyCellularComponentneuromuscular junction

LAMC1 SYNGR3 SYNGR4

4.45e-04112283GO:0031594
GeneOntologyCellularComponentbasolateral plasma membrane

CASR CLCNKA SLC30A1 SLC14A2

8.26e-04320284GO:0016323
GeneOntologyCellularComponentapical part of cell

CASR CLCNKA SLC14A2 ABCA7 FRMD1

1.03e-03592285GO:0045177
GeneOntologyCellularComponentbasal plasma membrane

CASR CLCNKA SLC30A1 SLC14A2

1.20e-03354284GO:0009925
GeneOntologyCellularComponentcytoplasmic vesicle membrane

SV2C SLC9A9 SLC30A1 ABCA7 SYNGR3 SYNGR4 TMEM179B

1.36e-031307287GO:0030659
GeneOntologyCellularComponentvesicle membrane

SV2C SLC9A9 SLC30A1 ABCA7 SYNGR3 SYNGR4 TMEM179B

1.47e-031325287GO:0012506
GeneOntologyCellularComponentbasal part of cell

CASR CLCNKA SLC30A1 SLC14A2

1.53e-03378284GO:0045178
GeneOntologyCellularComponentexocytic vesicle membrane

SV2C SYNGR3 SYNGR4

1.73e-03179283GO:0099501
GeneOntologyCellularComponentsynaptic vesicle membrane

SV2C SYNGR3 SYNGR4

1.73e-03179283GO:0030672
GeneOntologyCellularComponentT-tubule

CACNG1 SLC30A1

5.00e-0379282GO:0030315
DomainSynaptogyrin

SYNGR3 SYNGR4

1.12e-054262IPR016579
DomainMARVEL

SYNGR3 SYNGR4

6.40e-0427262PF01284
DomainMARVEL

SYNGR3 SYNGR4

6.89e-0428262PS51225
DomainMarvel

SYNGR3 SYNGR4

6.89e-0428262IPR008253
DomainAden_trnslctor

SLC25A2 SLC25A15

6.89e-0428262IPR002113
DomainSOLCAR

SLC25A2 SLC25A15

2.46e-0353262PS50920
DomainMito_carr

SLC25A2 SLC25A15

2.46e-0353262PF00153
DomainMt_carrier_dom

SLC25A2 SLC25A15

2.46e-0353262IPR023395
Domain-

SLC25A2 SLC25A15

2.46e-03532621.50.40.10
DomainMitochondrial_sb/sol_carrier

SLC25A2 SLC25A15

2.46e-0353262IPR018108
PathwayREACTOME_UREA_CYCLE

SLC25A2 SLC25A15

7.70e-0510192M27677
PathwayREACTOME_UREA_CYCLE

SLC25A2 SLC25A15

7.70e-0510192MM15396
Pubmed

Cloning and characterization of human ORNT2: a second mitochondrial ornithine transporter that can rescue a defective ORNT1 in patients with the hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a urea cycle disorder.

SLC25A2 SLC25A15

6.25e-07228212948741
Pubmed

Substrate specificity of the two mitochondrial ornithine carriers can be swapped by single mutation in substrate binding site.

SLC25A2 SLC25A15

6.25e-07228222262851
Pubmed

The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms.

SLC25A2 SLC25A15

6.25e-07228212807890
Pubmed

Characterization of the human synaptogyrin gene family.

SYNGR3 SYNGR4

6.24e-0652829760194
Pubmed

CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice.

TOMM20L SLC25A2

4.85e-051328234290169
Pubmed

The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.

CASR SLC9A9 SLC14A2

6.54e-0421228319521566
Pubmed

Tuning of Glutamate, But Not GABA, Release by an Intrasynaptic Vesicle APP Domain Whose Function Can Be Modulated by β- or α-Secretase Cleavage.

SV2C SYNGR3

6.61e-044728231235642
GeneFamilySolute carriers

SLC9A9 SLC30A1 SLC14A2 SLC25A2 SLC25A15

3.29e-05395185752
CoexpressionGSE12484_HEALTHY_VS_PERIDONTITIS_NEUTROPHILS_UP

CACNG1 TOMM20L RASL12 GPR27

1.03e-05139264M433
ComputationalIon channels.

CACNG1 CLCNKA SLC14A2

1.39e-0470163MODULE_316
Diseaseornithine translocase deficiency (implicated_via_orthology)

SLC25A2 SLC25A15

8.06e-072272DOID:0050720 (implicated_via_orthology)
Diseaseparathyroid hormone measurement

CASR SLC25A2

1.16e-0355272EFO_0004752
Diseaselifestyle measurement, alcohol consumption measurement

SLC9A9 ENTPD3

4.96e-03115272EFO_0007878, EFO_0010724

Protein segments in the cluster

PeptideGeneStartEntry
AAAAAAAAAAAFPCL

BHLHE41

401

Q9C0J9
ILAASFGLLACIFFN

CASR

841

P41180
LSAFFSRANLAAACG

ABCA7

646

Q8IZY2
SFACACAAFILLFLG

CACNG1

181

Q06432
LAFFTAAALLCLAFL

ENTPD3

491

O75355
ALAGRFGCLFFEVSA

RASL12

151

Q9NYN1
LLGNSEVFAAFCRAL

FANCF

241

Q9NPI8
ALCGVAVFLAAAAAG

CCDC194

16

A0A1B0GVG4
LAALFCFHAAFLLLG

GPR27

101

Q9NS67
AYFLLAACALQADLG

FRMD1

181

Q8N878
RAVALLFGCSSAALA

ESPL1

2021

Q14674
CFFLLLLAAAGARAG

MAN2B1

36

O00754
GALFPVCAAFVALAV

CDH26

616

Q8IXH8
LAVLAAAAAAGCAQA

LAMC1

21

P11047
FAACEAAVGLALLVS

MT-ND4L

66

P03901
LALFAAAFLCGAVAA

TMEM179B

11

Q7Z7N9
FGFLNALCKAAAVLG

SV2C

671

Q496J9
AAVAAGFCASFLLGS

PKDCC

6

Q504Y2
FILGAFLAIFVARAC

SLC9A9

396

Q8IVB4
GAGATALAFLSFCII

SIGLEC8

366

Q9NYZ4
AAGSFASAFAALVLC

SLC25A15

111

Q9Y619
AAGSFASAFAALALC

SLC25A2

111

Q9BXI2
FAATCGAFIFRLLAV

CLCNKA

241

P51800
LGAFLACAAFLLLDV

SYNGR3

76

O43761
GAGFLAFLSCLAFLV

SYNGR4

71

O95473
GLALLVLALGFFAAC

TMEM275

66

A0A0U1RQS6
SLLRLLAAAAACGAF

TOMM20L

6

Q6UXN7
GALVNAIFLTGLCFA

SLC30A1

81

Q9Y6M5
ACALFAAYLGAALAN

SLC14A2

836

Q15849