Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	PRAMEF4 PRAMEF9 PRAMEF26 PRAMEF27 PRAMEF15	6.07e-07	82	40	5	GO:1990756
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	PRAMEF4 PRAMEF9 PRAMEF26 PRAMEF27 PRAMEF15	1.26e-06	95	40	5	GO:0140767
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF15	4.37e-06	55	40	4	GO:0042974
GeneOntologyMolecularFunction	nuclear receptor binding	PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	3.44e-05	187	40	5	GO:0016922
GeneOntologyMolecularFunction	lipid kinase activity	PIKFYVE PIK3CG DGKK	7.53e-05	41	40	3	GO:0001727
GeneOntologyMolecularFunction	DNA replication origin binding	ORC4 GRWD1	5.87e-04	18	40	2	GO:0003688
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PIKFYVE PIK3CG	1.23e-03	26	40	2	GO:0052742
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	1.40e-03	417	40	5	GO:0061629
GeneOntologyBiologicalProcess	negative regulation of apoptotic process	WT1 PRAMEF25 PRAMEF4 PRAMEF9 RB1CC1 PRAMEF26 PRAMEF27 PTH PIK3CG ESR1 HTT PRAMEF15	1.27e-06	1133	41	12	GO:0043066
GeneOntologyBiologicalProcess	negative regulation of programmed cell death	WT1 PRAMEF25 PRAMEF4 PRAMEF9 RB1CC1 PRAMEF26 PRAMEF27 PTH PIK3CG ESR1 HTT PRAMEF15	1.80e-06	1171	41	12	GO:0043069
GeneOntologyBiologicalProcess	female gamete generation	ASPM ORC4 MSH5 PRAMEF4 PRAMEF15	7.71e-05	223	41	5	GO:0007292
GeneOntologyBiologicalProcess	positive regulation of cell population proliferation	ASPM FER PRAMEF25 PRAMEF4 PRAMEF9 PRAMEF26 PRAMEF27 PTH ESR1 PRAMEF15	8.53e-05	1190	41	10	GO:0008284
GeneOntologyBiologicalProcess	multicellular organismal reproductive process	ASPM FER WT1 TSNAXIP1 ORC4 MSH5 PRAMEF4 ESR1 HTT PRAMEF15	8.77e-05	1194	41	10	GO:0048609
GeneOntologyBiologicalProcess	gamete generation	ASPM FER WT1 TSNAXIP1 ORC4 MSH5 PRAMEF4 HTT PRAMEF15	1.07e-04	982	41	9	GO:0007276
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF4 PRAMEF9 PRAMEF26 PRAMEF27 PRAMEF15	3.26e-08	47	41	5	GO:0031462
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	PRAMEF4 PRAMEF9 PRAMEF26 PRAMEF27 PRAMEF15	5.70e-05	212	41	5	GO:0031461
GeneOntologyCellularComponent	transferase complex	PRAMEF4 PRAMEF9 RB1CC1 PRAMEF26 PRAMEF27 PIK3CG POLE PRAMEF15	4.85e-04	963	41	8	GO:1990234
GeneOntologyCellularComponent	ubiquitin ligase complex	PRAMEF4 PRAMEF9 PRAMEF26 PRAMEF27 PRAMEF15	5.99e-04	352	41	5	GO:0000151
MousePheno	abnormal spermatogonia proliferation	PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF15	2.88e-06	47	30	4	MP:0002685
MousePheno	decreased testis weight	ASPM MSH5 PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	1.03e-05	370	30	7	MP:0004852
MousePheno	azoospermia	WT1 MSH5 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF15	1.11e-05	244	30	6	MP:0005159
MousePheno	abnormal male germ cell physiology	ASPM MSH5 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF15	1.11e-05	244	30	6	MP:0020362
MousePheno	absent gametes	WT1 MSH5 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF15	1.46e-05	256	30	6	MP:0001117
MousePheno	abnormal testis weight	ASPM MSH5 PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	1.48e-05	391	30	7	MP:0004850
MousePheno	abnormal germ cell physiology	ASPM MSH5 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF15	1.85e-05	267	30	6	MP:0020363
MousePheno	abnormal sperm number	ASPM WT1 MSH5 PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	3.68e-05	624	30	8	MP:0002673
MousePheno	decreased male germ cell number	ASPM WT1 MSH5 PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	4.41e-05	640	30	8	MP:0004901
MousePheno	increased male germ cell apoptosis	MSH5 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF15	4.64e-05	189	30	5	MP:0014052
MousePheno	small gonad	ASPM WT1 POSTN MSH5 PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	6.69e-05	885	30	9	MP:0001116
MousePheno	decreased germ cell number	ASPM WT1 MSH5 PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	7.29e-05	687	30	8	MP:0002209
MousePheno	abnormal primary sex determination	ASPM WT1 POSTN MSH5 PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	7.69e-05	901	30	9	MP:0002211
MousePheno	abnormal sex determination	ASPM WT1 POSTN MSH5 PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	1.11e-04	945	30	9	MP:0002210
MousePheno	infertility	WT1 POSTN EVC MSH5 PRAMEF4 ODAD2 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	1.17e-04	1188	30	10	MP:0001924
MousePheno	short ulna	POSTN EVC ESR1	1.27e-04	46	30	3	MP:0004359
MousePheno	decreased ulna size	POSTN EVC ESR1	1.27e-04	46	30	3	MP:0030900
MousePheno	abnormal male germ cell apoptosis	MSH5 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF15	1.33e-04	236	30	5	MP:0008280
MousePheno	increased apoptosis	WT1 MSH5 PRAMEF4 RB1CC1 PRAMEF26 PRAMEF27 PTH HTT PRAMEF15	1.82e-04	1008	30	9	MP:0006042
MousePheno	abnormal gametes	ASPM WT1 MSH5 PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	1.85e-04	785	30	8	MP:0001124
MousePheno	limbs/digits/tail phenotype	POSTN EVC EIF3C PRAMEF4 DIS3L2 SEPTIN5 DHTKD1 PTH ESR1 PRAMEF15	1.88e-04	1258	30	10	MP:0005371
MousePheno	increased cell death	WT1 MSH5 PRAMEF4 RB1CC1 PRAMEF26 PRAMEF27 PTH HTT PRAMEF15	1.98e-04	1019	30	9	MP:0012556
MousePheno	impaired granulosa cell differentiation	WT1 ESR1	1.98e-04	10	30	2	MP:0003357
MousePheno	small testis	ASPM WT1 MSH5 PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	2.56e-04	823	30	8	MP:0001147
MousePheno	abnormal male reproductive system physiology	ASPM WT1 TSNAXIP1 MSH5 PRAMEF4 ODAD2 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	2.96e-04	1329	30	10	MP:0003698
MousePheno	abnormal male germ cell morphology	ASPM WT1 MSH5 PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	3.42e-04	859	30	8	MP:0006362
MousePheno	abnormal spermatogenesis	ASPM WT1 MSH5 PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	5.05e-04	910	30	8	MP:0001156
MousePheno	abnormal testis size	ASPM WT1 MSH5 PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	5.24e-04	915	30	8	MP:0004849
MousePheno	decreased myelin sheath thickness	DHTKD1 HTT	5.24e-04	16	30	2	MP:0011731
MousePheno	small ovary	ASPM WT1 POSTN MSH5	5.38e-04	178	30	4	MP:0001127
MousePheno	abnormal epiphyseal plate morphology	POSTN EVC PTH ESR1	6.22e-04	185	30	4	MP:0006395
MousePheno	male infertility	WT1 MSH5 PRAMEF4 ODAD2 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	6.45e-04	944	30	8	MP:0001925
MousePheno	abnormal germ cell morphology	ASPM WT1 MSH5 PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	6.54e-04	946	30	8	MP:0002208
MousePheno	abnormal foam cell morphology	ASPM WT1 MSH5 PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	6.92e-04	954	30	8	MP:0009840
MousePheno	abnormal ulna morphology	POSTN EVC ESR1	7.56e-04	84	30	3	MP:0005108
MousePheno	abnormal internal female genitalia morphology	ASPM WT1 POSTN MSH5 FCRLA ZNF804A ESR1	9.04e-04	757	30	7	MP:0009209
MousePheno	abnormal female genitalia morphology	ASPM WT1 POSTN MSH5 FCRLA ZNF804A ESR1	9.47e-04	763	30	7	MP:0009208
MousePheno	abnormal female reproductive system morphology	ASPM WT1 POSTN MSH5 FCRLA ZNF804A ESR1	9.69e-04	766	30	7	MP:0001119
MousePheno	abnormal male reproductive gland morphology	ASPM FER WT1 MSH5 PRAMEF4 PRAMEF26 PRAMEF27 ESR1 PRAMEF15	1.13e-03	1290	30	9	MP:0013325
Domain	PRAME_family	PRAMEF25 PRAMEF4 PRAMEF27 PRAMEF15	6.15e-08	19	39	4	IPR026271
Domain	-	PRAMEF25 PRAMEF4 PRAMEF27 PRAMEF15 PHLPP2 NLRP8	4.98e-05	321	39	6	3.80.10.10
Domain	L_dom-like	PRAMEF25 PRAMEF4 PRAMEF27 PRAMEF15 PHLPP2 NLRP8	5.61e-05	328	39	6	IPR032675
Domain	FCH	FER FCHO1	9.56e-04	22	39	2	PF00611
Domain	FCH	FER FCHO1	9.56e-04	22	39	2	SM00055
Domain	FCH_dom	FER FCHO1	1.05e-03	23	39	2	IPR001060
Domain	F_BAR	FER FCHO1	1.24e-03	25	39	2	IPR031160
Domain	F_BAR	FER FCHO1	1.24e-03	25	39	2	PS51741
Domain	ARM-type_fold	ASPM ODAD2 PIK3CG HTT	5.32e-03	339	39	4	IPR016024
Domain	HEAT	ODAD2 HTT	6.52e-03	58	39	2	IPR000357
Domain	HEAT_REPEAT	ODAD2 HTT	9.38e-03	70	39	2	PS50077
Domain	-	ASPM ODAD2 HTT	1.11e-02	222	39	3	1.25.10.10
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF15	1.20e-08	22	41	4	31729367
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF15	2.06e-08	25	41	4	37451217
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF15	3.33e-08	28	41	4	25089626
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF15	8.47e-08	35	41	4	19389355
Pubmed	Wilms' tumor 1 suppressor gene mediates antiestrogen resistance via down-regulation of estrogen receptor-alpha expression in breast cancer cells.	WT1 ESR1	1.36e-06	2	41	2	18708366
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF4 PRAMEF27 PRAMEF15	1.71e-06	20	41	3	26694250
Pubmed	Periostin is a collagen associated bone matrix protein regulated by parathyroid hormone.	POSTN PTH	4.06e-06	3	41	2	20654714
Pubmed	The WT1 Wilms' tumor suppressor gene product interacts with estrogen receptor-alpha and regulates IGF-I receptor gene transcription in breast cancer cells.	WT1 ESR1	4.06e-06	3	41	2	16087727
Pubmed	Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin.	POSTN PTH	4.06e-06	3	41	2	22927401
Pubmed	Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart.	WT1 ESR1	4.06e-06	3	41	2	20025864
Pubmed	Genetic effects of estrogen receptor alpha and collagen IA1 genes on the relationships of parathyroid hormone and 25 hydroxyvitamin D with bone mineral density in Caucasian women.	PTH ESR1	4.06e-06	3	41	2	14506618
Pubmed	Loss of Dis3l2 partially phenocopies Perlman syndrome in mice and results in up-regulation of Igf2 in nephron progenitor cells.	WT1 DIS3L2	4.06e-06	3	41	2	29950491
Pubmed	Common variations in 4p locus are related to male completed suicide.	EVC HTT	8.12e-06	4	41	2	19115052
Pubmed	Distinct association of gene polymorphisms of estrogen receptor and vitamin D receptor with lumbar spondylosis in post-menopausal women.	PTH ESR1	8.12e-06	4	41	2	16362385
Pubmed	Association of gene polymorphisms and bone density in Japanese girls.	PTH ESR1	1.35e-05	5	41	2	11984699
Pubmed	Association of bone metabolism regulatory factor gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity.	PTH ESR1	1.35e-05	5	41	2	12195069
Pubmed	Differentiation of Caucasians and Chinese at bone mass candidate genes: implication for ethnic difference of bone mass.	PTH ESR1	1.35e-05	5	41	2	12914574
Pubmed	Wt1 and epicardial fate mapping.	WT1 POSTN	1.35e-05	5	41	2	22693350
Pubmed	Contribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese: a test for five candidate genes for bone mass.	PTH ESR1	1.35e-05	5	41	2	16117875
Pubmed	Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart.	WT1 POSTN	6.07e-05	10	41	2	22546693
Pubmed	Novel role for the orphan nuclear receptor Dax1 in embryogenesis, different from steroidogenesis.	WT1 ESR1	6.07e-05	10	41	2	16466956
Pubmed	A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.	PTH ESR1	7.41e-05	11	41	2	18285546
Pubmed	Genetic Lineage Tracing of Nonmyocyte Population by Dual Recombinases.	WT1 POSTN	7.41e-05	11	41	2	29700121
Pubmed	Epithelial-to-mesenchymal transition in epicardium is independent of Snail1.	WT1 POSTN	8.88e-05	12	41	2	23097346
Pubmed	Left-sided cryptorchidism in mice with Wilms' tumour 1 gene deletion in gubernaculum testis.	WT1 ESR1	1.05e-04	13	41	2	23288785
Pubmed	CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy.	WT1 POSTN	1.05e-04	13	41	2	22343712
Pubmed	Tbx18 function in epicardial development.	WT1 POSTN	1.05e-04	13	41	2	22926762
Pubmed	Tbx5 is required for avian and Mammalian epicardial formation and coronary vasculogenesis.	WT1 POSTN	1.22e-04	14	41	2	25245104
Pubmed	Huntingtin functions as a scaffold for selective macroautophagy.	RB1CC1 HTT	1.41e-04	15	41	2	25686248
Pubmed	Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development.	WT1 POSTN	1.61e-04	16	41	2	27253890
Pubmed	Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice.	WT1 POSTN	1.61e-04	16	41	2	21266775
Pubmed	Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling.	WT1 POSTN	1.82e-04	17	41	2	21512159
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF4 PRAMEF15	1.82e-04	17	41	2	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF4 PRAMEF15	1.82e-04	17	41	2	37781892
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF4 PRAMEF15	2.05e-04	18	41	2	23894331
Pubmed	DNA replication in eukaryotic cells.	ORC4 POLE	2.05e-04	18	41	2	12045100
Pubmed	Huntingtin regulates mammary stem cell division and differentiation.	ESR1 HTT	2.05e-04	18	41	2	24749073
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF4 PRAMEF15	2.05e-04	18	41	2	12890732
Pubmed	Wilms Tumor Predisposition	WT1 DIS3L2	2.05e-04	18	41	2	20301471
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF4 PRAMEF15	2.05e-04	18	41	2	29731491
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF4 PRAMEF15	2.05e-04	18	41	2	14675769
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF4 PRAMEF15	2.05e-04	18	41	2	39181896
Pubmed	TBX2-positive cells represent a multi-potent mesenchymal progenitor pool in the developing lung.	WT1 POSTN	2.29e-04	19	41	2	31870435
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF4 PRAMEF15	2.29e-04	19	41	2	28604677
Pubmed	Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development.	WT1 POSTN	2.54e-04	20	41	2	21350214
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF4 PRAMEF15	2.54e-04	20	41	2	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF4 PRAMEF15	2.54e-04	20	41	2	21425410
Pubmed	β-Catenin directs the transformation of testis Sertoli cells to ovarian granulosa-like cells by inducing Foxl2 expression.	WT1 ESR1	2.81e-04	21	41	2	28900034
Pubmed	BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer	RB1CC1 ESR1	2.81e-04	21	41	2	20301425
Pubmed	Epicardial function of canonical Wnt-, Hedgehog-, Fgfr1/2-, and Pdgfra-signalling.	WT1 POSTN	3.09e-04	22	41	2	24000064
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF4 PRAMEF15	3.38e-04	23	41	2	19480014
Pubmed	Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development.	EVC HTT	3.38e-04	23	41	2	11597144
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF4 PRAMEF15	4.00e-04	25	41	2	12620990
Pubmed	Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development.	WT1 POSTN	4.00e-04	25	41	2	22536403
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF4 PRAMEF15	4.33e-04	26	41	2	18500982
Pubmed	Genetic loci influencing natural variations in femoral bone morphometry in mice.	EIF3C PTH	4.67e-04	27	41	2	11518254
Pubmed	Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.	DCDC1 ESR1	4.67e-04	27	41	2	19801982
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE2A PIK3CG	4.67e-04	27	41	2	11156964
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	DHTKD1 PIK3CG ESR1 HTT	5.01e-04	313	41	4	20800603
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF4 PRAMEF15	5.78e-04	30	41	2	38786026
Pubmed	Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.	ASPM PRAMEF4 ESR1 PRAMEF15	5.84e-04	326	41	4	17015433
Pubmed	Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening.	POSTN ESR1	6.17e-04	31	41	2	32546759
Pubmed	Crim1 has cell-autonomous and paracrine roles during embryonic heart development.	WT1 POSTN	6.17e-04	31	41	2	26821812
Pubmed	Wnt/β-catenin signaling maintains the mesenchymal precursor pool for murine sinus horn formation.	WT1 POSTN	6.17e-04	31	41	2	21757651
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF4 PRAMEF15	6.58e-04	32	41	2	37889087
Pubmed	Global Proximity Interactome of the Human Macroautophagy Pathway.	RB1CC1 HTT	7.87e-04	35	41	2	34524948
Pubmed	Notch signaling regulates smooth muscle differentiation of epicardium-derived cells.	WT1 POSTN	7.87e-04	35	41	2	21252157
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	ASPM PRAMEF4 RB1CC1 PRAMEF15	8.71e-04	363	41	4	14691545
Pubmed	Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.	MSH5 ESR1	1.03e-03	40	41	2	20378615
Interaction	PRAMEF4 interactions	PRAMEF4 PRAMEF9	1.09e-05	3	39	2	int:PRAMEF4
Cytoband	1p36.21	PRAMEF25 PRAMEF4 PRAMEF9 PRAMEF26 PRAMEF15	2.98e-09	63	41	5	1p36.21
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	PRAMEF25 PRAMEF4 PRAMEF9 PRAMEF26 PRAMEF27 PRAMEF15	3.01e-05	681	41	6	chr1p36
Cytoband	11p13	WT1 DCDC1	1.16e-03	56	41	2	11p13
Cytoband	Ensembl 112 genes in cytogenetic band chr11p13	WT1 DCDC1	1.56e-03	65	41	2	chr11p13
GeneFamily	PRAME family	PRAMEF25 PRAMEF4 PRAMEF9 PRAMEF26 PRAMEF27 PRAMEF15	3.65e-12	24	34	6	686
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	FER FCHO1	8.47e-04	23	34	2	1288
Coexpression	KOHOUTEK_CCNT2_TARGETS	PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF15	7.11e-06	81	40	4	MM938
CoexpressionAtlas	dev lower uro neuro_e15.5_BladdPelvicGanglion_Sox10_k-means-cluster#1_top-relative-expression-ranked_100	POSTN ZNF804A DGKK	1.09e-05	28	33	3	gudmap_dev lower uro neuro_e15.5_BladdPelvicGanglion_Sox10_k1_100
Disease	chronic kidney disease (is_marker_for)	WT1 POSTN PTH	1.57e-06	20	34	3	DOID:784 (is_marker_for)
Disease	common variable immunodeficiency	MSH5 FCRLA	2.70e-05	7	34	2	MONDO_0015517
Disease	nephroblastoma (is_implicated_in)	WT1 DIS3L2	1.16e-04	14	34	2	DOID:2154 (is_implicated_in)
Disease	BREAST CANCER	RB1CC1 ESR1	2.67e-04	21	34	2	114480
Disease	osteoporosis (biomarker_via_orthology)	PTH ESR1	2.93e-04	22	34	2	DOID:11476 (biomarker_via_orthology)
Disease	Malignant tumor of breast	RB1CC1 ESR1	4.44e-04	27	34	2	cv:C0006142
Disease	Breast neoplasm	RB1CC1 ESR1	4.44e-04	27	34	2	cv:C1458155
Disease	Familial cancer of breast	RB1CC1 ESR1	4.44e-04	27	34	2	cv:C0346153
Disease	lung non-small cell carcinoma (is_implicated_in)	MSH5 POLE ESR1	5.50e-04	139	34	3	DOID:3908 (is_implicated_in)
Disease	Bright Disease	WT1 ESR1	5.87e-04	31	34	2	C1704377
Disease	Glomerulonephritis	WT1 ESR1	5.87e-04	31	34	2	C0017658
Disease	Nephroblastoma	WT1 DIS3L2	7.92e-04	36	34	2	C0027708
Disease	bone quantitative ultrasound measurement	SEPTIN5 ESR1	9.30e-04	39	34	2	EFO_0004514
Disease	Mood Disorders	ZNF804A ESR1 HTT	9.53e-04	168	34	3	C0525045
Disease	Congenital small ears	ORC4 EVC	1.03e-03	41	34	2	C0152423
Disease	blood phosphate measurement	DCDC1 PTH ESR1	1.05e-03	174	34	3	EFO_0010972
Disease	primary immunodeficiency disease (is_implicated_in)	FCHO1 PIK3CG	1.08e-03	42	34	2	DOID:612 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QMHSHLLKTHVQSRM	DHTKD1	546	Q96HY7
MLLANMAVAHKIHRA	DIS3L2	586	Q8IYB7
RRHLKMMHIAATLIQ	ASPM	2256	Q8IZT6
LQRSAAHMRHLLMSQ	RBFA	156	Q8N0V3
AHMRHLLMSQQTLRN	RBFA	161	Q8N0V3
NISKNLRSLHMLLML	ORC4	271	O43929
HANQLMIMLQNHRKL	RB1CC1	416	Q8TDY2
QAMEETHLRHMKALL	FCHO1	201	O14526
IQTDHMMERLLLKIH	DCDC1	521	M0R2J8
QMAMSRIINLHHHRI	DGKK	976	Q5KSL6
NRLMMLRMHNLHGTK	GRWD1	101	Q9BQ67
QAMASMLRKNQHLRH	NLRP8	971	Q86W28
QLLLILSHIRHMSNK	ESR1	506	P03372
NNKQHHRLLLCLLMT	PDE2A	791	O00408
GHMRNLQKLVLSHMD	PRAMEF15	231	P0DUQ1
ALHRTLHNMMKKLFL	POLE	1836	Q07864
MNALHSLLHTLLMNS	OR1G1	151	P47890
RDLMLMSHLQDNIQH	EIF3C	586	Q99613
ERLLSANHNHMMALL	PIKFYVE	606	Q9Y2I7
LQKAHVMSVLHEMLQ	IFNW1	71	P05000
SMALQQAHLLKNMSH	HTT	621	P42858
MKLHMLHNQYVLALK	FER	176	P16591
KHMQDVRVLLGHLLM	FCRLA	326	Q7L513
LLHLDTALRQEKHMM	EVC	221	P57679
MILQAHLHSLCLLML	CDH17	1	Q12864
HMRNLQKLVLSHMDV	PRAMEF26	136	H0Y7S4
DMAQMLHRLLGHIKN	MSH5	301	O43196
VKLRNMLIRTHMHDL	SEPTIN5	281	Q99719
IAMLLKQLDLHLLNH	ODAD2	171	Q5T2S8
GHMRNLQKLVLSHMD	PRAMEF25	231	A6NGN4
GHMRNLQKLVLSHMD	PRAMEF27	231	A3QJZ7
QLKTMHNLRLLRADM	C12orf4	281	Q9NQ89
RHHTNLLIILFSMML	PIK3CG	1021	P48736
GHMRNLQKLILSHMD	PRAMEF4	231	O60810
LNRMNHIKHVDLRMN	PHLPP2	411	Q6ZVD8
GHMRNLQKLVLSHMD	PRAMEF9	231	P0DUQ2
TLQANMKRHMLIHTS	ZNF710	501	Q8N1W2
LVRHHNMHQRNMTKL	WT1	431	P19544
LLNALHSHMINKRML	POSTN	161	Q15063
IQLMHNLGKHLNSME	PTH	36	P01270
RKEHEILMQLHMSTL	TSNAXIP1	286	Q2TAA8
HKSMRDRHVNMHLNL	ZBTB22	496	O15209
HRSLVLQNDMKHMSQ	ZNF804A	736	Q7Z570