Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

HCN2 HCN3 SCN7A

1.58e-0626183GO:0005248
GeneOntologyMolecularFunctionsodium channel activity

HCN2 HCN3 SCN7A

1.32e-0552183GO:0005272
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

HCN2 SLC22A1 HCN3 SCN7A

1.45e-05171184GO:0015081
GeneOntologyMolecularFunctionintracellularly cAMP-activated cation channel activity

HCN2 HCN3

3.44e-0510182GO:0005222
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

HCN2 SLC22A1 KCNH7 HCN3 SCN7A

4.47e-05465185GO:0046873
GeneOntologyMolecularFunctionintracellularly cyclic nucleotide-activated monoatomic cation channel activity

HCN2 HCN3

5.95e-0513182GO:0005221
GeneOntologyMolecularFunctioncyclic nucleotide-activated monoatomic ion channel activity

HCN2 HCN3

5.95e-0513182GO:0043855
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

HCN2 KCNH7 HCN3

9.99e-05102183GO:0005249
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

HCN2 SLC22A1 KCNH7 HCN3 SCN7A

1.83e-04627185GO:0022890
GeneOntologyMolecularFunctiongated channel activity

HCN2 KCNH7 HCN3 SCN7A

1.95e-04334184GO:0022836
GeneOntologyMolecularFunctionpotassium channel activity

HCN2 KCNH7 HCN3

1.96e-04128183GO:0005267
GeneOntologyMolecularFunctionmonoatomic cation channel activity

HCN2 KCNH7 HCN3 SCN7A

2.16e-04343184GO:0005261
GeneOntologyMolecularFunctioncAMP binding

HCN2 HCN3

2.27e-0425182GO:0030552
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

HCN2 SLC22A1 KCNH7 HCN3 SCN7A

2.39e-04664185GO:0008324
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

HCN2 KCNH7 HCN3

2.55e-04140183GO:0099094
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

HCN2 KCNH7 HCN3

3.24e-04152183GO:0022843
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

HCN2 HCN3

3.99e-0433182GO:0005217
GeneOntologyMolecularFunctiontransmembrane transporter activity

HCN2 SVOP SLC22A1 KCNH7 HCN3 SCN7A

4.22e-041180186GO:0022857
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

HCN2 KCNH7 HCN3

4.27e-04167183GO:0015079
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

HCN2 SLC22A1 KCNH7 HCN3 SCN7A

4.41e-04758185GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

HCN2 SLC22A1 KCNH7 HCN3 SCN7A

5.43e-04793185GO:0015075
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

HCN2 KCNH7 HCN3

5.49e-04182183GO:0005244
GeneOntologyMolecularFunctioncyclic nucleotide binding

HCN2 HCN3

5.58e-0439182GO:0030551
GeneOntologyMolecularFunctionvoltage-gated channel activity

HCN2 KCNH7 HCN3

5.67e-04184183GO:0022832
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

HCN2 KCNH7 HCN3

6.52e-04193183GO:0015276
GeneOntologyMolecularFunctionmonoatomic ion channel activity

HCN2 KCNH7 HCN3 SCN7A

6.53e-04459184GO:0005216
GeneOntologyMolecularFunctiontransporter activity

HCN2 SVOP SLC22A1 KCNH7 HCN3 SCN7A

6.76e-041289186GO:0005215
GeneOntologyMolecularFunctionligand-gated channel activity

HCN2 KCNH7 HCN3

6.92e-04197183GO:0022834
GeneOntologyMolecularFunctionchannel activity

HCN2 KCNH7 HCN3 SCN7A

1.08e-03525184GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

HCN2 KCNH7 HCN3 SCN7A

1.09e-03526184GO:0022803
GeneOntologyMolecularFunctionPDZ domain binding

HCN2 TBC1D10A

5.40e-03123182GO:0030165
GeneOntologyCellularComponentHCN channel complex

HCN2 HCN3

4.69e-064192GO:0098855
GeneOntologyCellularComponentmonoatomic ion channel complex

HCN2 KCNH7 HCN3 SCN7A

3.29e-04378194GO:0034702
GeneOntologyCellularComponenttransmembrane transporter complex

HCN2 KCNH7 HCN3 SCN7A

1.11e-03523194GO:1902495
GeneOntologyCellularComponentcation channel complex

HCN2 HCN3 SCN7A

1.19e-03235193GO:0034703
GeneOntologyCellularComponenttransporter complex

HCN2 KCNH7 HCN3 SCN7A

1.34e-03550194GO:1990351
GeneOntologyCellularComponentvoltage-gated potassium channel complex

HCN2 HCN3

3.05e-0391192GO:0008076
GeneOntologyCellularComponentpotassium channel complex

HCN2 HCN3

3.97e-03104192GO:0034705
GeneOntologyCellularComponentcaveola

CAV2 EFNA5

4.50e-03111192GO:0005901
GeneOntologyCellularComponentplasma membrane protein complex

HCN2 HCN3 CAV2 SCN7A

4.87e-03785194GO:0098797
GeneOntologyCellularComponentbasement membrane

COL4A4 EFNA5

5.41e-03122192GO:0005604
GeneOntologyCellularComponentplasma membrane raft

CAV2 EFNA5

7.77e-03147192GO:0044853
DomainK_chnl_volt-dep_EAG/ELK/ERG

HCN2 KCNH7 HCN3

3.23e-0714193IPR003938
DomainCNMP_BINDING_1

HCN2 KCNH7 HCN3

4.35e-0632193PS00888
DomainCNMP_BINDING_2

HCN2 KCNH7 HCN3

4.35e-0632193PS00889
DomainIon_trans_dom

HCN2 KCNH7 HCN3 SCN7A

4.75e-06114194IPR005821
DomainIon_trans

HCN2 KCNH7 HCN3 SCN7A

4.75e-06114194PF00520
DomaincNMP

HCN2 KCNH7 HCN3

5.24e-0634193SM00100
DomaincNMP_binding

HCN2 KCNH7 HCN3

5.24e-0634193PF00027
DomaincNMP-bd_dom

HCN2 KCNH7 HCN3

5.72e-0635193IPR000595
DomainCNMP_BINDING_3

HCN2 KCNH7 HCN3

5.72e-0635193PS50042
DomainIon_trans_N

HCN2 HCN3

5.88e-064192PF08412
DomainIon_trans_N

HCN2 HCN3

5.88e-064192IPR013621
DomaincNMP-bd-like

HCN2 KCNH7 HCN3

7.36e-0638193IPR018490
Domain-

HCN2 KCNH7 HCN3

1.50e-05481932.60.120.10
DomainRmlC-like_jellyroll

HCN2 KCNH7 HCN3

1.80e-0551193IPR014710
DomainOrgcat_transp/SVOP

SVOP SLC22A1

3.51e-059192IPR004749
DomainSugar_tr

SVOP SLC22A1

6.05e-0436192PF00083
DomainMFS_sugar_transport-like

SVOP SLC22A1

6.05e-0436192IPR005828
DomainMFS

SVOP SLC22A1

5.31e-03108192PS50850
DomainMFS_dom

SVOP SLC22A1

8.07e-03134192IPR020846
PathwayREACTOME_POTASSIUM_CHANNELS

HCN2 KCNH7 HCN3

1.40e-0498153MM14545
PathwayREACTOME_POTASSIUM_CHANNELS

HCN2 KCNH7 HCN3

1.62e-04103153M1073
PathwayREACTOME_NEURONAL_SYSTEM

HCN2 SLC22A1 KCNH7 HCN3

3.47e-04335154MM14503
PathwayREACTOME_NEURONAL_SYSTEM

HCN2 SLC22A1 KCNH7 HCN3

7.53e-04411154M735
PathwayWP_SPLICING_FACTOR_NOVA_REGULATED_SYNAPTIC_PROTEINS

CAV2 EFNA5

8.88e-0442152MM15822
PathwayWP_SPLICING_FACTOR_NOVA_REGULATED_SYNAPTIC_PROTEINS

CAV2 EFNA5

8.88e-0442152M39703
Pubmed

Hyperpolarization-activated cyclic nucleotide-modulated 'HCN' channels confer regular and faster rhythmicity to beating mouse embryonic stem cells.

HCN2 HCN3

2.83e-07219218033814
Pubmed

HCN3 ion channels: roles in sensory neuronal excitability and pain.

HCN2 HCN3

2.83e-07219231290157
Pubmed

A family of hyperpolarization-activated mammalian cation channels.

HCN2 HCN3

8.48e-0731929634236
Pubmed

Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization.

HCN2 KCNH7

8.48e-07319215961404
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

HCN2 KCNH7 HCN3 SCN7A

9.04e-0713919416985003
Pubmed

Functional expression of the human HCN3 channel.

HCN2 HCN3

1.70e-06419216043489
Pubmed

Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia.

HCN2 HCN3

1.70e-06419225042871
Pubmed

Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice.

HCN2 HCN3

1.70e-06419220140458
Pubmed

Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.

HCN2 HCN3

1.70e-06419222748890
Pubmed

Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.

HCN2 HCN3

1.70e-0641929630217
Pubmed

Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons.

HCN2 HCN3

1.70e-06419226966193
Pubmed

Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.

HCN2 HCN3

1.70e-0641929405696
Pubmed

Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.

HCN2 HCN3

1.70e-06419212928435
Pubmed

Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.

HCN2 HCN3

1.70e-06419221615589
Pubmed

Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice.

HCN2 HCN3

2.82e-06519234429357
Pubmed

Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons.

HCN2 HCN3

2.82e-06519230886335
Pubmed

Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.

HCN2 HCN3

2.82e-06519215564593
Pubmed

Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.

HCN2 HCN3

5.93e-06719227956497
Pubmed

Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.

HCN2 HCN3

5.93e-06719219421833
Pubmed

International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.

HCN2 HCN3

1.27e-051019216382102
Pubmed

Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.

HCN2 HCN3

2.56e-051419229107716
Pubmed

Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice.

COL4A4 EFNA5

3.01e-044719215172686
Pubmed

Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.

SLC22A1 CAV2

3.01e-044719211208732
InteractionHCN4 interactions

HCN2 HCN3

3.02e-059192int:HCN4
CytobandEnsembl 112 genes in cytogenetic band chr2q24

KCNH7 SCN7A

1.26e-03127192chr2q24
GeneFamilyCyclic nucleotide gated channels

HCN2 HCN3

1.51e-0510112250
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-2|TCGA-Brain / Sample_Type by Project: Shred V9

COL4A4 XKR5 KCNH7 HCN3

2.27e-07127194018ffd9ff1913787cb0086a8581b399a121eaba1
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A4 KCNH7 EFNA5 SCN7A

2.65e-07132194295980f70645ee2934145e9959c01f999044da3e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A4 KCNH7 EFNA5 SCN7A

3.55e-071421945b6b0c611c83b23ef7289854a515b78f6cf84500
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A4 KCNH7 EFNA5 SCN7A

1.11e-061891947eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A4 KCNH7 EFNA5 SCN7A

1.11e-06189194975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SVOP KCNH7 SCN7A

2.76e-051401935e81fa3a19d23f0e9cae3878431ca1f78dff7238
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SVOP KCNH7 SCN7A

3.45e-05151193f41c6558a5874b6464c157027fdf202257c60e5b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

XKR5 EFNA5 SCN7A

5.35e-05175193787ac1a12cda10af5c8830471702a4cbaf43e79e
ToppCellCOVID-19-Epithelial_cells-AT1|COVID-19 / group, cell type (main and fine annotations)

COL4A4 CAV2 DUOXA1

5.73e-05179193a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KCNH7 EFNA5 SCN7A

5.73e-05179193666072c0e8448dbaec1683d18368ec2502453f90
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A4 EFNA5 SCN7A

5.92e-0518119322363c5835dd6cef8f895ab9362e0837d92b15b1
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KCNH7 EFNA5 SCN7A

6.02e-051821935f513bbb7125956eb528e3120de3fd776770a7c3
ToppCellCOVID-19-lung-AT1|lung / Disease (COVID-19 only), tissue and cell type

COL4A4 CAV2 DUOXA1

6.11e-05183193942530449e9c6583705eeb8f6f12621daea57252
ToppCellCOVID-19-lung-AT1|COVID-19 / Disease (COVID-19 only), tissue and cell type

COL4A4 CAV2 DUOXA1

6.11e-051831937b1a385ed54f93bfe85bf0c162e42d05d516b45c
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CAV2 EFNA5 DUOXA1

6.11e-05183193ec2af3402b51f11466d2a5783a6b33746b6a7fc9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KCNH7 EFNA5 SCN7A

6.52e-05187193f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CAV2 SCN7A DUOXA1

6.62e-0518819300c5259bcb83218b7d44f4d585d9b68ef49763ab
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KCNH7 EFNA5 SCN7A

6.73e-05189193e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A4 DNAH6 EFNA5

6.73e-05189193e059be2965cca70ff5576df055d0af1775b76e00
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A4 EFNA5 SCN7A

6.73e-0518919355420853f730b433ef58ac9337ac84ac78a247a0
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CAV2 EFNA5 UGCG

6.94e-051911931eef30384cb6721974f318daf0b8bdd25d1b8206
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KCNH7 CAV2 UGCG

6.94e-05191193a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D122|Adult / Lineage, Cell type, age group and donor

SIAE EFNA5 DUOXA1

7.05e-0519219306013a07e3a873b1d1c0451643c528593ac32a9c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A4 EFNA5 UGCG

7.38e-05195193938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A4 EFNA5 UGCG

7.38e-05195193d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SIAE EFNA5 DUOXA1

7.72e-051981932e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CAV2 EFNA5 UGCG

7.72e-05198193eaeb70c0f7f7ca21f7d5bc5ea6c7c1a49a293c45
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CAV2 EFNA5 UGCG

7.72e-051981939ec0ed556860e5543d327f4bf2370efc571ad75e
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SIAE EFNA5 DUOXA1

7.72e-05198193f948391296c261c473d339069a6d0f20ccd6f38f
ToppCellParenchymal-10x5prime-Epithelial-Epi_alveolar-AT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A4 CAV2 DUOXA1

7.84e-05199193aca81a879ef9c196bd1885eff4c63ffe6c9682b7
ToppCellBiopsy_Control_(H.)-Epithelial-Transitional_AT2|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

COL4A4 CAV2 DUOXA1

7.84e-05199193e04a57a55c724091db353e2b3baf84372d788728
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-AT1|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

COL4A4 CAV2 DUOXA1

7.84e-051991933e35ee426ef06f9af568c37349b62dd1ee9b97ea
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-AT1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

COL4A4 CAV2 DUOXA1

7.84e-05199193f8846446ebbc4948cdc69640782db1358bbdc486
ToppCellParenchyma_COVID-19-Epithelial-TX-AT1|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

COL4A4 CAV2 DUOXA1

7.84e-05199193fe9f5bc317be0c35bd96311bf0b3c7b91d98acc5
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Ndst4_(Superficial_layer_pyramidal_cells--dorsal_endopiriform_nucleus_or_piriform_cortex)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

LEAP2 XKR5

3.25e-04631921f609765ed8b3a09095427da5dab7ba03a763192
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P2-Tnr|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SLC22A1 DUOXA1

4.48e-04741921712898d8dd95f752f5da86307e0eedb7b82a709
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SLC22A1 DUOXA1

4.48e-04741920ec7e9c21459e02e8a2fefcc3a2230921ddbb4e8
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SLC22A1 DUOXA1

4.48e-0474192216dce5613d897ebd620c72b6b1d370c2c766666
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P2|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SLC22A1 DUOXA1

4.48e-0474192a994111e4aa0f19e1a1360b8636a16e10cbaf5d3
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_4|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

COL4A4 EFNA5

5.37e-04811928cb94dda18010b3b05e5ab72235850483013c03a
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_4|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

COL4A4 EFNA5

7.52e-04961927e02df1f28fea1d962f9b1d3835212765a6642cc
ToppCellCOVID-19-kidney-Mito-rich_Int|COVID-19 / Disease (COVID-19 only), tissue and cell type

SVOP KCNH7

1.21e-03122192a4220adb4e6055a599bd9bbf65d460fc4e68b543
ToppCellLPS_only-Endothelial-Epi-like|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HCN2 COL4A4

1.29e-031261924c598f7bae09aca7a4ecce63dfd6890b26468c73
ToppCellControl-PLT_5|World / Disease Group and Platelet Clusters

SVOP SCN7A

1.29e-031261924ba753c4e83eb1d41964edfa22135e047f06c481
ToppCellLPS_only-Endothelial-Epi-like-Gen_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HCN2 COL4A4

1.29e-03126192e065304f480a5e38532b66508b0ee87cc48bba9b
ToppCellCOVID-19-kidney-Mito-rich_Int|kidney / Disease (COVID-19 only), tissue and cell type

SVOP KCNH7

1.35e-0312919257b705106aec7bbfc587de1ccd4f2335fc44dd6f
ToppCellPBMC-Mild-Myeloid-Neutrophil-Neutrophil-Neu_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OR51V1 XKR5

1.41e-0313219282f312a561d9fdd2ebc2c25926dfc2b333ff0a4f
ToppCellPBMC-Mild-Myeloid-Neutrophil-Neutrophil-Neu_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

OR51V1 XKR5

1.41e-03132192fe87cb22e13e17df29ad43327f1aa71361907582
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KCNH7 EFNA5

1.48e-0313519252b5c664c0b7a303c6084d508748dcb6c38a0c23
ToppCellPBMC-Control-Hematopoietic-Platelet-Platelet-plt_5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SVOP SCN7A

1.50e-0313619227a41463e6f16deb5b1d4f17fefded9959038c07
ToppCellPBMC-Control-Hematopoietic-Platelet-Platelet-plt_5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SVOP SCN7A

1.50e-0313619288b5c839d0446c6d6b7e81fc4d48f5e7e96eea11
ToppCellControl-Neu_1|World / 5 Neutrophil clusters in COVID-19 patients

SIAE EFNA5

1.54e-03138192b7920c9a28d28220e7e4b30cd91ba13d0548eb76
ToppCellEndothelial-F|World / shred on cell class and cell subclass (v4)

CAV2 SCN7A

1.57e-0313919232d3c5d35e6c4205711c3500d736fd108443e6b4
ToppCellAT1-AT2_cells-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

COL4A4 CAV2

1.59e-0314019245d52a086ced8d58e01ac51ac4a90338e8649b16
ToppCell356C-Epithelial_cells-Epithelial-E_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

COL4A4 CAV2

1.61e-0314119231e0984f09983e83a814424f74c871c1c5a3a789
ToppCell356C-Epithelial_cells-Epithelial-E_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

COL4A4 CAV2

1.61e-03141192d7d3c3932651d90fa4f3c4e3df16f4b677faaf9f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KCNH7 SCN7A

1.66e-03143192990844ca674d30b2924c74b45bed4fdfb8463fa7
ToppCellfacs-MAT-Fat-18m-Epithelial-epithelial_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HCN2 SLC22A1

1.68e-03144192fd852095dcd716ac53b0fd25d83e6f454b2ae794
ToppCellfacs-MAT-Fat-18m-Epithelial-nan|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HCN2 SLC22A1

1.68e-0314419265ffd8a1620b178d995fe8c913871f0b376b896f
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo1_Itga4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CAV2 SCN7A

1.68e-031441927de962346ba9653d90dd13bb7d977fe44d200bba
ToppCellfacs-MAT-Fat-18m-Epithelial|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HCN2 SLC22A1

1.68e-03144192e4e148007c772cd163a34fb172e05184f7352a2b
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CAV2 SCN7A

1.72e-031461922d907e50206c4762a8baa741363bc7f0a04bd84e
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEAP2 SLC22A1

1.75e-03147192a5ed71afe5fcb4f541080f5552252695c7d4d090
ToppCellMS-CD4-CD8_2|MS / Condition, Cell_class and T cell subcluster

SVOP HCN3

1.80e-0314919208fb6be5599c5988890c851ce5ac6781c319948e
ToppCell368C-Fibroblasts-Fibroblast-F-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

COL4A4 DUOXA1

1.80e-031491929286bc56ff2e245630537a0bda5f1a1e17be863a
ToppCell368C-Fibroblasts-Fibroblast-F|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

COL4A4 DUOXA1

1.80e-03149192f53151d9e5e724a61be0ee6a8c740d1990f28d5f
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_ductal_cel|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEAP2 SLC22A1

1.80e-031491927726957b1de638c3bfc659381d15eab626bb179b
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EFNA5 SCN7A

1.82e-03150192909ccab92855f5f049dc29593aadab1ea973297b
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

XKR5 SCN7A

1.84e-0315119232d35906f4b2bd46b173e87f2dec972eb5da87b3
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

LEAP2 SCN7A

1.87e-03152192621e9b33cd3bb1c7b7d0633069f286b203e3d9c0
ToppCellP07-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COL4A4 LEAP2

1.89e-031531925501095bcf73080872ae01128f21399f9cfc5dd1
ToppCellE16.5-samps-Endothelial-Immature_fetal_endothelial-Matrix_Endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

CAV2 SCN7A

1.92e-03154192928f49839b046b90c2f942458f3e365ddc4e0bc9
ToppCellEpithelial-Epithelial-B_(AT1-AT2-progenitors)|Epithelial / shred on cell class and cell subclass (v4)

SVOP XKR5

1.92e-03154192770712806e26f73456fb77a81aa4ef8ec78a21ea
ToppCellfacs-Marrow-KLS-18m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAV2 SCN7A

1.92e-0315419237765512dfae557b9f6eb30a29463b93682a4404
ToppCelldroplet-Liver-Npc-21m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A4 XKR5

1.94e-031551925d600e159738231d0607ea1a1ebd8510fc241b36
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_3|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

SLC22A1 UGCG

1.94e-03155192335cd798afbaa0a3a3e1dc558a81cfa32da48983
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CAV2 SCN7A

1.94e-031551923b8def9e8f66511736ea37f259511f7c8b7743af
ToppCellPND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_C|PND01-03-samps / Age Group, Lineage, Cell class and subclass

CAV2 SCN7A

1.97e-031561926c8f442ed94ae31e6832b68137e98ae78091ac6c
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

SLC22A1 UGCG

1.97e-03156192fc8b8aef29d6d1c0f0c1d08280d8aaff8d30535e
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A4 SCN7A

1.97e-031561924d2679e7639758c49fc25a2deb9109b08f0a3e57
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_3|367C / Donor, Lineage, Cell class and subclass (all cells)

SLC22A1 UGCG

2.01e-031581920559cc032d0b518bb9e55aa3495f5573bd8e87dd
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KCNH7 EFNA5

2.01e-031581927960337d87afecf2692ab65e5991f052ceddfacc
ToppCellFLU-Healthy-1|Healthy / Virus stimulation, Condition and Cluster

LEAP2 EFNA5

2.04e-0315919297c8e16a7ac10ebba96daee97f9fb1d4a404f23b
ToppCellFLU-Healthy-1|FLU / Virus stimulation, Condition and Cluster

LEAP2 EFNA5

2.04e-03159192fe2a9f79b058e89214256e736f6e266830cdfa28
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_1|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

XKR5 EFNA5

2.07e-031601925cd4fbbd2ce671a8377416eff94041a111375dee
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SCN7A DUOXA1

2.07e-0316019214dfa519e68bab4bce890ddb66fa7763f18d9f19
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SCN7A DUOXA1

2.07e-031601925b7789d4668ed7732babedc32d812233b430e0bd
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

COL4A4 CAV2

2.07e-0316019258ed3a074932ccc951e07868dfdc61b99ae1cc2b
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_SOX11|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL4A4 SCN7A

2.07e-031601924cc34f40b56da39fbd26592fbdb4c07e7318d306
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SCN7A DUOXA1

2.07e-03160192bba1486faaad5299e10f4fe17c6d149c28dc2560
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SCN7A DUOXA1

2.07e-03160192839bbdfd4e4c7b48260c8bfb7670378634405e1d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KCNH7 EFNA5

2.07e-031601922d391ba6f7adb55dfa89feecc10cc9ce97e5fe74
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KCNH7 EFNA5

2.07e-031601928bcdbcfdf1e0ace6053e8de82762f6e2f86bba7a
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEAP2 SLC22A1

2.07e-03160192c42bcc6c7d113f0db43febb088b75ca4ac7cb7a3
ToppCellfacs-Lung-nan-3m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC22A1 UGCG

2.09e-03161192ae1cee34361dde9964581cca99a29578c3b3bd99
ToppCellPCW_13-14-Neuronal-Neuronal_postreplicative-neuro_immature_neuronal_(2)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SVOP KCNH7

2.09e-03161192bb9cb42882aaa4a1ecf9b480c0e7ac302f2c0d5d
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma|TCGA-Brain / Sample_Type by Project: Shred V9

SVOP KCNH7

2.09e-031611925f6b2d7f80a8ee16651e304481d2da3fae313824
ToppCellfacs-Lung-nan-3m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC22A1 UGCG

2.09e-0316119233de3e8b3238fcfc66dfbf89a913a07d464d6c35
ToppCellAT1_cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

COL4A4 CAV2

2.12e-03162192ae2ba4f21f6f6c512006fa531d670b88be7c04c9
ToppCellAT1-AT2_cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

COL4A4 CAV2

2.12e-0316219257d627259d27f39885bf416d74bcb6656db6e27b
Diseaseepilepsy (implicated_via_orthology)

KCNH7 SCN7A

4.38e-03163182DOID:1826 (implicated_via_orthology)
Diseasepost-traumatic stress disorder

EFNA5 FAM120A

6.64e-03202182EFO_0001358
Diseaseopioid dependence

KCNH7 UGCG

9.03e-03237182EFO_0005611

Protein segments in the cluster

PeptideGeneStartEntry
MWSLHIVLMRCSFRL

COL4A4

1

P53420
VLMLLMCIFALIAHW

KCNH7

551

Q9NS40
MVLLGNCMVLHVIWT

OR51V1

46

Q9H2C8
HLMVLCCVLRYMVQW

FAM120A

711

Q9NZB2
MSHRLCVLLMGAAWV

OR13J1

136

Q8NGT2
IFNLIGMMLLLCHWD

HCN3

251

Q9P1Z3
CHLAVSWMLAMEELI

DNAH6

3601

Q9C0G6
FVLFLVLWLMHFMAI

UGCG

16

Q16739
MLHVEMLTLVFLVLW

EFNA5

1

P52803
HIWILMPFVKTCLMV

CAV2

111

P51636
VAFLCWLLANVMLSM

DUOXA1

186

Q1HG43
DLHWLNIIIMCVGRM

SLC22A1

426

O15245
RICNLISMMLLLCHW

HCN2

366

Q9UL51
MMILSILAPQLHCEW

SVOP

101

Q8N4V2
MWHLKLCAVLMIFLL

LEAP2

1

Q969E1
VLWNAMIHPLCNMTL

SIAE

256

Q9HAT2
VFLVCLMIWLIFSIM

SCN7A

1061

Q01118
CSLMMLHLLQLGVWK

XKR5

66

Q6UX68
LLMHMPAEQAFWCLV

TBC1D10A

206

Q9BXI6