Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsupercoiled DNA binding

HMGB1 ABL1

4.99e-056372GO:0097100
GeneOntologyMolecularFunctionDNA secondary structure binding

HMGB1 ABL1 H1-0

5.95e-0541373GO:0000217
GeneOntologyMolecularFunctionADP-D-ribose modification-dependent protein binding

MACROH2A1 XRCC1

6.97e-057372GO:0160002
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

PRDM2 SETBP1 ASH1L

7.36e-0544373GO:0140938
GeneOntologyMolecularFunctionbubble DNA binding

HMGB1 ABL1

9.29e-058372GO:0000405
GeneOntologyMolecularFunctionhistone H3K9 methyltransferase activity

PRDM2 ASH1L

2.57e-0413372GO:0046974
GeneOntologyMolecularFunctionnucleosomal DNA binding

MACROH2A1 HMGN3 H1-0

2.59e-0467373GO:0031492
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

PRDM2 SETBP1 ASH1L

2.70e-0468373GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

PRDM2 SETBP1 ASH1L

2.82e-0469373GO:0016278
GeneOntologyMolecularFunction5S rRNA binding

HMGB1 RPL4

3.00e-0414372GO:0008097
GeneOntologyMolecularFunctionhistone methyltransferase activity

PRDM2 SETBP1 ASH1L

3.07e-0471373GO:0042054
GeneOntologyMolecularFunctionfour-way junction DNA binding

HMGB1 ABL1

5.60e-0419372GO:0000400
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

SETBP1 ASH1L

6.22e-0420372GO:0042800
GeneOntologyMolecularFunctioncytoskeletal protein binding

APC KIFAP3 PHACTR2 ABL1 MYLK MAP6 REEP3 ARHGEF7

7.59e-041099378GO:0008092
GeneOntologyMolecularFunctionnucleosome binding

MACROH2A1 HMGN3 H1-0

7.89e-0498373GO:0031491
GeneOntologyMolecularFunctionhistone modifying activity

PHF2 PRDM2 SETBP1 ASH1L

8.27e-04229374GO:0140993
GeneOntologyMolecularFunctionprotein methyltransferase activity

PRDM2 SETBP1 ASH1L

9.12e-04103373GO:0008276
GeneOntologyMolecularFunctionN-methyltransferase activity

PRDM2 SETBP1 ASH1L

9.64e-04105373GO:0008170
GeneOntologyMolecularFunctionchromatin DNA binding

MACROH2A1 HMGN3 H1-0

3.62e-03167373GO:0031490
GeneOntologyMolecularFunctionS-adenosylmethionine-dependent methyltransferase activity

PRDM2 SETBP1 ASH1L

3.94e-03172373GO:0008757
GeneOntologyBiologicalProcesschromatin organization

PHF2 HMGB1 MACROH2A1 ERCC6L DEK HMGN3 VCX PRDM2 SETBP1 H1-0 ASH1L

4.00e-078963811GO:0006325
GeneOntologyBiologicalProcessprotein-DNA complex organization

PHF2 HMGB1 MACROH2A1 ERCC6L DEK HMGN3 VCX PRDM2 SETBP1 H1-0 ASH1L

1.17e-069993811GO:0071824
GeneOntologyBiologicalProcesschromatin remodeling

PHF2 HMGB1 MACROH2A1 ERCC6L DEK PRDM2 SETBP1 H1-0 ASH1L

6.07e-06741389GO:0006338
GeneOntologyBiologicalProcessregulation of rDNA heterochromatin formation

PHF2 MACROH2A1

9.90e-063382GO:0061187
GeneOntologyBiologicalProcessbrain development

PCSK1 TACC2 VCX2 VCX3B ABL1 VCX3A XRCC1 ARHGAP35 VCX

1.98e-05859389GO:0007420
GeneOntologyBiologicalProcesspositive regulation of cell projection organization

APC ABL1 ARHGAP35 MAP6 ARHGEF7 RPL4 EIF4G2

2.87e-05494387GO:0031346
GeneOntologyBiologicalProcesspositive regulation of DNA ligation

HMGB1 XRCC1

3.29e-055382GO:0051106
GeneOntologyBiologicalProcesshead development

PCSK1 TACC2 VCX2 VCX3B ABL1 VCX3A XRCC1 ARHGAP35 VCX

3.38e-05919389GO:0060322
GeneOntologyBiologicalProcessregulation of DNA ligation

HMGB1 XRCC1

4.93e-056382GO:0051105
GeneOntologyBiologicalProcessrDNA heterochromatin formation

PHF2 MACROH2A1

1.47e-0410382GO:0000183
GeneOntologyBiologicalProcessnucleolar chromatin organization

PHF2 MACROH2A1

1.80e-0411382GO:1990700
GeneOntologyBiologicalProcessregulation of microtubule-based process

APC TACC2 ABL1 MAP6 ARHGEF7

1.91e-04293385GO:0032886
GeneOntologyBiologicalProcessheterochromatin formation

PHF2 HMGB1 MACROH2A1 H1-0

2.25e-04163384GO:0031507
GeneOntologyBiologicalProcesscentral nervous system development

PCSK1 TACC2 VCX2 VCX3B ABL1 VCX3A XRCC1 ARHGAP35 VCX

2.56e-041197389GO:0007417
GeneOntologyBiologicalProcesspositive regulation of binding

HMGB1 ABL1 ARHGEF7 H1-0

2.64e-04170384GO:0051099
GeneOntologyBiologicalProcessregulation of microtubule polymerization

APC ABL1 ARHGEF7

2.78e-0469383GO:0031113
GeneOntologyBiologicalProcessregulation of microtubule cytoskeleton organization

APC ABL1 MAP6 ARHGEF7

3.02e-04176384GO:0070507
GeneOntologyBiologicalProcessdouble-strand break repair via nonhomologous end joining

HMGB1 XRCC1 DEK

3.84e-0477383GO:0006303
GeneOntologyBiologicalProcessDNA ligation

HMGB1 XRCC1

3.90e-0416382GO:0006266
GeneOntologyBiologicalProcessregulation of axonogenesis

ARHGAP35 MAP6 RPL4 EIF4G2

4.19e-04192384GO:0050770
GeneOntologyBiologicalProcessgland development

PCSK1 APC PHF2 ABL1 ARHGAP35 ASH1L

5.04e-04558386GO:0048732
GeneOntologyBiologicalProcessnegative regulation of gene expression, epigenetic

PHF2 HMGB1 MACROH2A1 H1-0

5.17e-04203384GO:0045814
GeneOntologyBiologicalProcessaxonogenesis

APC ABL1 ARHGAP35 MAP6 RPL4 EIF4G2

5.44e-04566386GO:0007409
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

APC ABL1 ARHGAP35 MAP6 ARHGEF7 RPL4 EIF4G2

6.52e-04819387GO:0120039
GeneOntologyBiologicalProcessnucleolus organization

PHF2 MACROH2A1

6.79e-0421382GO:0007000
GeneOntologyBiologicalProcesscell projection morphogenesis

APC ABL1 ARHGAP35 MAP6 ARHGEF7 RPL4 EIF4G2

6.86e-04826387GO:0048858
GeneOntologyBiologicalProcessregulation of anatomical structure morphogenesis

APC HMGB1 ABL1 ARHGAP35 MAP6 ARHGEF7 RPL4 EIF4G2

7.02e-041090388GO:0022603
GeneOntologyBiologicalProcessregulation of cell size

ABL1 ARHGAP35 RPL4 EIF4G2

7.61e-04225384GO:0008361
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection organization

APC ABL1 ARHGAP35 MAP6 ARHGEF7 RPL4 EIF4G2

7.90e-04846387GO:0120035
GeneOntologyBiologicalProcessregulation of DNA repair

HMGB1 ABL1 XRCC1 DEK

8.80e-04234384GO:0006282
GeneOntologyBiologicalProcessregulation of cell projection organization

APC ABL1 ARHGAP35 MAP6 ARHGEF7 RPL4 EIF4G2

8.88e-04863387GO:0031344
GeneOntologyBiologicalProcessregulation of heterochromatin formation

PHF2 MACROH2A1

8.89e-0424382GO:0031445
GeneOntologyBiologicalProcessregulation of axon extension

ABL1 RPL4 EIF4G2

9.24e-04104383GO:0030516
GeneOntologyCellularComponentcondensed chromosome

APC PHF2 KIFAP3 HMGB1 MACROH2A1 ERCC6L

2.07e-05307396GO:0000793
HumanPhenoInfantile sensorineural hearing impairment

PRG4 SETBP1

4.22e-055112HP:0008610
HumanPhenoSynostosis of joints

APC MACROH2A1 AEBP1 SETBP1 ASH1L

4.48e-05212115HP:0100240
MousePhenolethality during fetal growth through weaning, incomplete penetrance

PCSK1 APC PHF2 EPS15L1 ELK3 ABL1 ARHGAP35 AEBP1 ERCC6L MAP6 SRRM4

1.63e-0511243111MP:0011112
DomainVCX/VCY1

VCX2 VCX3B VCX3A VCX

7.27e-115384IPR026653
DomainVCX_VCY

VCX2 VCX3B VCX3A VCX

7.27e-115384PF15231
Domain-

PCSK1 XRCC1 AEBP1

4.38e-04733832.60.120.260
DomainGalactose-bd-like

PCSK1 XRCC1 AEBP1

9.17e-0494383IPR008979
DomainAT_hook

SETBP1 ASH1L

1.37e-0327382SM00384
DomainAT_hook_DNA-bd_motif

SETBP1 ASH1L

1.37e-0327382IPR017956
DomainARM

APC KIFAP3

2.99e-0340382SM00185
DomainARM_REPEAT

APC KIFAP3

2.99e-0340382PS50176
DomainSET

PRDM2 ASH1L

3.14e-0341382PF00856
DomainSET

PRDM2 ASH1L

3.94e-0346382SM00317
DomainArmadillo

APC KIFAP3

4.11e-0347382IPR000225
DomainSET_dom

PRDM2 ASH1L

4.64e-0350382IPR001214
DomainSET

PRDM2 ASH1L

4.64e-0350382PS50280
DomainZinc_finger_PHD-type_CS

PHF2 ASH1L

7.73e-0365382IPR019786
DomainHMG_box_dom

HMGB1 NT5C1A

7.73e-0365382IPR009071
DomainPHD

PHF2 ASH1L

1.02e-0275382PF00628
DomainZnf_PHD-finger

PHF2 ASH1L

1.13e-0279382IPR019787
DomainPHD

PHF2 ASH1L

1.41e-0289382SM00249
PathwayWP_REGULATION_OF_ACTIN_CYTOSKELETON

APC ARHGAP35 MYLK CHRM2 ARHGEF7

8.53e-06150275M39520
PathwayWP_REGULATION_OF_ACTIN_CYTOSKELETON

APC ARHGAP35 MYLK CHRM2 ARHGEF7

9.10e-06152275MM15834
PathwayKEGG_BASE_EXCISION_REPAIR

HMGB1 XRCC1 HMGB1P1

3.94e-0535273M5500
PathwayKEGG_REGULATION_OF_ACTIN_CYTOSKELETON

APC ARHGAP35 MYLK CHRM2 ARHGEF7

4.63e-05213275M18306
PathwayREACTOME_APOPTOTIC_EXECUTION_PHASE

APC HMGB1 H1-0

1.09e-0449273MM15448
PathwayREACTOME_APOPTOTIC_EXECUTION_PHASE

APC HMGB1 H1-0

1.30e-0452273M2341
PathwayREACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION

HMGB1 H1-0

2.30e-0412272MM14554
PathwayWP_HISTONE_MODIFICATIONS

PRDM2 SETBP1 ASH1L

2.53e-0465273M39374
PathwayREACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION

HMGB1 H1-0

2.72e-0413272M1018
Pubmed

A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation.

VCX2 VCX3B VCX3A VCX

1.50e-12440410903929
Pubmed

Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis.

VCX2 VCX3B VCX3A

1.41e-09340318076704
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

MACROH2A1 ELK3 PHACTR2 ABL1 XRCC1 MYLK PRG4 HMGN3

3.48e-0932940817474147
Pubmed

A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins.

VCX2 VCX3A VCX

1.41e-08540310607842
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

APC EPS15L1 XRCC1 ARHGAP35 ERCC6L H1-0 ASH1L EIF4G2

1.00e-0668940836543142
Pubmed

Modulation of neuritogenesis by a protein implicated in X-linked mental retardation.

VCX3B VCX3A

1.29e-06240219812318
Pubmed

Secreted HMGB1 from Wnt activated intestinal cells is required to maintain a crypt progenitor phenotype.

APC HMGB1

1.29e-06240227323825
Pubmed

Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis.

VCX3B VCX

1.29e-06240212862317
Pubmed

Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function.

ABL1 MYLK

1.29e-06240220861316
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

PHF2 MACROH2A1 XRCC1 DEK HMGN3 H1-0 ASH1L

2.30e-0653340730554943
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

EPS15L1 ELK3 ARHGAP35 ERCC6L PRG4 REXO1 PRDM2 EIF4G2

2.38e-0677440815302935
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

APC PHF2 HMGB1 MACROH2A1 ARHGAP35 MAP6 DEK ARHGEF7 RPL4

3.03e-06108240938697112
Pubmed

Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance.

HMGB1 H1-0

3.87e-06340219158276
Pubmed

Essential roles of high-mobility group box 1 in the development of murine colitis and colitis-associated cancer.

APC HMGB1

3.87e-06340217599806
Pubmed

Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity.

ABL1 ARHGAP35

3.87e-06340222396406
Pubmed

DNA repair pathway profiling and microsatellite instability in colorectal cancer.

HMGB1 XRCC1

3.87e-06340216951227
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

APC EPS15L1 TACC2 MACROH2A1 ARHGAP35 MAP6 ARHGEF7 H1-0 EIF4G2

4.60e-06113940936417873
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PHF2 EPS15L1 MACROH2A1 ELK3 ANKRD12 ARHGAP35 REEP3 PCDH1 SETBP1 ASH1L

5.25e-061489401028611215
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

APC MACROH2A1 XRCC1 ERCC6L RPL4 PRDM2

5.98e-0639840635016035
Pubmed

Nup358 interacts with APC and plays a role in cell polarization.

APC KIFAP3

7.73e-06440219654215
Pubmed

Identification of a link between the tumour suppressor APC and the kinesin superfamily.

APC KIFAP3

7.73e-06440211912492
Pubmed

An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth.

APC ABL1

7.73e-06440225834110
Pubmed

Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA Vasculitis (IgAV).

HMGB1 PCDH1

7.73e-06440238673968
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

PHF2 HMGB1 EPS15L1 MACROH2A1 XRCC1 DEK HMGB1P1 EIF4G2

1.10e-0595440836373674
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

PHF2 HMGB1 XRCC1 DEK HMGN3 RPL4 PRDM2 H1-0 EIF4G2

1.28e-05129440930804502
Pubmed

The histone variant macroH2A confers functional robustness to the intestinal stem cell compartment.

APC MACROH2A1

1.29e-05540228934364
Pubmed

Analysis of histone variant constraint and tissue expression suggests five potential novel human disease genes: H2AFY2, H2AFZ, H2AFY, H2AFV, H1F0.

MACROH2A1 H1-0

1.29e-05540235072799
Pubmed

Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis.

HMGB1 PRG4

1.93e-05640219139395
Pubmed

Inhibition of Rho via Arg and p190RhoGAP in the postnatal mouse hippocampus regulates dendritic spine maturation, synapse and dendrite stability, and behavior.

ABL1 ARHGAP35

1.93e-05640217928439
Pubmed

Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice.

APC KIFAP3

1.93e-05640231746486
Pubmed

A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family.

VCX3B VCX

1.93e-05640217342728
Pubmed

Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation.

APC ABL1

2.70e-05740217318191
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

APC HMGB1 EPS15L1 ARHGAP35 MAP6 PCDH1 RPL4 H1-0 EIF4G2

2.84e-05143140937142655
Pubmed

TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA.

PHF2 HMGB1 DEK RPL4 H1-0

3.09e-0531740530997501
Pubmed

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.

MACROH2A1 MAP6 PCDH1 ARHGEF7 RPL4 EIF4G2

4.01e-0555840635063084
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

EPS15L1 MACROH2A1 PHACTR2 PCDH1 C6orf132 EIF4G2

4.30e-0556540625468996
Pubmed

Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries.

MACROH2A1 SRRM4

5.77e-051040212800201
Pubmed

UbE2E1/UBCH6 Is a Critical in Vivo E2 for the PRC1-catalyzed Ubiquitination of H2A at Lys-119.

MACROH2A1 H1-0

7.05e-051140228073915
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

HMGB1 EPS15L1 ARHGAP35 DEK ARHGEF7 HMGN3 EIF4G2

7.50e-0591640732203420
Pubmed

HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity.

MACROH2A1 XRCC1

8.45e-051240227067600
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

EPS15L1 TACC2 MACROH2A1 ARHGAP35 ERCC6L RPL4 EIF4G2

8.47e-0593440733916271
Pubmed

The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity.

MACROH2A1 DEK

9.98e-051340217158748
Pubmed

Serine ADP-Ribosylation Depends on HPF1.

HMGB1 H1-0

1.34e-041540228190768
Pubmed

14-3-3sigma controls mitotic translation to facilitate cytokinesis.

DEK RPL4 H1-0

1.35e-048640317361185
Pubmed

Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.

KIFAP3 NT5C1A

1.53e-041640219451621
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

PHF2 HMGB1 MACROH2A1 DEK RPL4 PRDM2 H1-0 EIF4G2

1.86e-04142540830948266
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

HMGB1 MACROH2A1 PHACTR2 MYLK HMGN3 RPL4 H1-0 ASH1L

2.01e-04144240835575683
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

APC HMGB1 MACROH2A1 ARHGEF7 RPL4

2.06e-0447540531040226
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

APC TACC2 ANKRD12 MAP6 PRDM2 ASH1L EIF4G2

2.13e-04108440711544199
Pubmed

Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.

APC KIFAP3

2.18e-041940217002498
Pubmed

Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.

APC EIF4G2

2.42e-042040221689717
Pubmed

The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis.

HMGB1 MYLK

3.21e-042340220207250
Pubmed

Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.

PHF2 HMGB1 RPL4

3.26e-0411640337117180
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

APC PHACTR2 ABL1 ERCC6L REEP3 C6orf132

4.23e-0486140636931259
Pubmed

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.

HMGB1 MACROH2A1 DEK

4.66e-0413140334551306
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

APC PHF2 AEBP1 DEK H1-0 ASH1L

4.67e-0487740620211142
Pubmed

Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.

ABL1 ARHGEF7

4.78e-042840218067320
Pubmed

Landscape of the SOX2 protein-protein interactome.

MACROH2A1 XRCC1 RPL4

5.20e-0413640321280222
Pubmed

Isolation and characterization of proteins associated with histone H3 tails in vivo.

HMGB1 ASH1L

5.50e-043040217403666
Pubmed

Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3.

HMGB1 MACROH2A1 XRCC1 RPL4

5.68e-0433240430595499
Pubmed

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

MACROH2A1 DEK C6orf132 H1-0

6.21e-0434040429478914
Pubmed

SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.

HMGB1 MACROH2A1 HMGB1P1 H1-0 EIF4G2

6.33e-0460740539147351
Pubmed

An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.

ELK3 DEK

6.66e-043340230783098
Pubmed

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.

MACROH2A1 DEK RPL4 H1-0 EIF4G2

8.08e-0464140536057605
Pubmed

Linking nuclear matrix-localized PIAS1 to chromatin SUMOylation via direct binding of histones H3 and H2A.Z.

MACROH2A1 HMGN3 HMGB1P1

8.18e-0415940334537242
Pubmed

Nuclear High Mobility Group A2 (HMGA2) Interactome Revealed by Biotin Proximity Labeling.

HMGB1 MACROH2A1

8.37e-043740236835656
Pubmed

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.

MACROH2A1 DEK

9.79e-044040228805822
Pubmed

Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.

APC XRCC1 PRDM2

9.93e-0417040319064572
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

HMGB1 MACROH2A1 XRCC1 DEK HMGN3 EIF4G2

9.95e-04101440632416067
Pubmed

Human variation in alcohol response is influenced by variation in neuronal signaling genes.

MACROH2A1 ABL1 CHRM2

1.01e-0317140320201926
Pubmed

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.

HMGB1 XRCC1 PRDM2

1.11e-0317740326206133
Pubmed

Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.

MACROH2A1 XRCC1 DEK

1.13e-0317840327637333
InteractionH2BC9 interactions

HMGB1 MACROH2A1 PHACTR2 ERCC6L DEK HMGN3 RPL4 SETBP1 H1-0 ASH1L

6.92e-094463810int:H2BC9
InteractionSFN interactions

APC HMGB1 ABL1 ERCC6L REEP3 DEK RPL4 C6orf132 H1-0

4.20e-06692389int:SFN
InteractionPRNP interactions

APC KIFAP3 HMGB1 EPS15L1 XRCC1 ARHGAP35 MYLK ERCC6L H1-0 ASH1L EIF4G2

6.14e-0611583811int:PRNP
InteractionBRD2 interactions

PHF2 MACROH2A1 ELK3 XRCC1 ERCC6L DEK H1-0

1.35e-05429387int:BRD2
InteractionBRD3 interactions

PHF2 MACROH2A1 XRCC1 DEK HMGN3 RPL4 H1-0

3.33e-05494387int:BRD3
InteractionH3-3A interactions

PHF2 HMGB1 MACROH2A1 XRCC1 DEK PRDM2 H1-0 ASH1L

6.37e-05749388int:H3-3A
InteractionHPF1 interactions

HMGB1 MACROH2A1 H1-0

6.75e-0542383int:HPF1
InteractionNUP43 interactions

APC PHF2 MACROH2A1 PRDM2 H1-0 ASH1L EIF4G2

1.46e-04625387int:NUP43
InteractionH2AC14 interactions

MACROH2A1 DEK HMGN3 H1-0

1.53e-04144384int:H2AC14
InteractionVCX2 interactions

MACROH2A1 VCX2

1.54e-0410382int:VCX2
InteractionH3-4 interactions

PHF2 MACROH2A1 DEK REXO1 PRDM2 H1-0

1.76e-04448386int:H3-4
InteractionCDC14B interactions

PHF2 HMGB1 XRCC1 DEK

2.18e-04158384int:CDC14B
InteractionNUMA1 interactions

HMGB1 MACROH2A1 XRCC1 RPL4 PRDM2 H1-0

2.26e-04469386int:NUMA1
InteractionH3C1 interactions

KIFAP3 HMGB1 MACROH2A1 XRCC1 DEK PRDM2 H1-0 ASH1L

2.29e-04901388int:H3C1
CytobandEnsembl 112 genes in cytogenetic band chrXp22

VCX2 VCX3B VCX3A VCX

6.72e-05250404chrXp22
CytobandXp22

VCX3A VCX

2.19e-0425402Xp22
GeneFamilyVariable charge X/Y family

VCX2 VCX3B VCX3A VCX

5.90e-116274368
GeneFamilyCanonical high mobility group

HMGB1 HMGN3

1.17e-0411272511
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

PRDM2 ASH1L

1.17e-0334272487
GeneFamilyPHD finger proteins

PHF2 ASH1L

7.93e-039027288
GeneFamilyHistones

MACROH2A1 H1-0

1.29e-02116272864
CoexpressionGSE14415_NATURAL_TREG_VS_TCONV_UP

APC TACC2 ARHGAP35 SETBP1 H1-0

4.41e-06160405M2976
CoexpressionMURARO_PANCREAS_BETA_CELL

PCSK1 APC ANKRD12 PHACTR2 ARHGAP35 MAP6 RPL4 SETBP1 ASH1L

9.98e-06946409M39169
CoexpressionGSE7460_CTRL_VS_TGFB_TREATED_ACT_TREG_DN

ELK3 ANKRD12 ABL1 PRG4 RPL4

1.27e-05199405M5682
CoexpressionGSE11961_MARGINAL_ZONE_BCELL_VS_MEMORY_BCELL_DAY40_UP

KIFAP3 PRG4 REEP3 HMGN3 C6orf132

1.30e-05200405M9324
CoexpressionHE_LIM_SUN_FETAL_LUNG_C1_INTERM_NEUROENDOCRINE_CELL

PCSK1 TACC2 MAP6 SRRM4 SETBP1

5.29e-05268405M45696
CoexpressionLINDGREN_BLADDER_CANCER_HIGH_RECURRENCE

MYLK AEBP1 H1-0

5.78e-0549403M2899
CoexpressionHADDAD_B_LYMPHOCYTE_PROGENITOR

ELK3 MYLK AEBP1 ARHGEF7 PRDM2

7.68e-05290405M939
CoexpressionGSE14699_NAIVE_VS_DELETIONAL_TOLERANCE_CD8_TCELL_UP

APC ARHGAP35 PRG4 ASH1L

8.44e-05152404M2938
CoexpressionHAY_BONE_MARROW_PRO_B

HMGB1 MACROH2A1 DEK HMGN3 EIF4G2

9.58e-05304405M39208
CoexpressionJOSEPH_RESPONSE_TO_SODIUM_BUTYRATE_DN

HMGB1 ELK3 EIF4G2

1.06e-0460403M1515
CoexpressionBLUM_RESPONSE_TO_SALIRASIB_DN

APC HMGB1 MACROH2A1 MYLK DEK

1.64e-04341405M2879
CoexpressionHE_LIM_SUN_FETAL_LUNG_C4_T_ALPHA_BETA_ENTRY_CELL

APC AEBP1 ARHGEF7

1.68e-0470403M45777
CoexpressionGUTIERREZ_WALDENSTROEMS_MACROGLOBULINEMIA_2

HMGB1 DEK

1.75e-0413402M17096
CoexpressionGSE6259_33D1_POS_DC_VS_CD4_TCELL_UP

HMGB1 MACROH2A1 HMGN3 RPL4

1.76e-04184404M6756
CoexpressionPUJANA_ATM_PCC_NETWORK

APC MACROH2A1 ELK3 ABL1 ARHGAP35 DEK HMGN3 RPL4 PRDM2

2.03e-041394409M9585
CoexpressionHOEGERKORP_CD44_TARGETS_DIRECT_DN

APC PRDM2

2.04e-0414402M1823
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

APC KIFAP3 ANKRD12 ARHGAP35 MAP6 PCDH1 SRRM4 PRDM2

2.26e-041106408M39071
CoexpressionGSE13306_LAMINA_PROPRIA_VS_SPLEEN_TREG_UP

PCSK1 ANKRD12 PRG4 REEP3

2.38e-04199404M3217
CoexpressionGSE36392_TYPE_2_MYELOID_VS_EOSINOPHIL_IL25_TREATED_LUNG_UP

ABL1 MYLK RPL4 H1-0

2.38e-04199404M5270
CoexpressionHALLMARK_MITOTIC_SPINDLE

APC KIFAP3 ABL1 ARHGEF7

2.38e-04199404M5893
CoexpressionGSE17721_CPG_VS_GARDIQUIMOD_6H_BMDC_UP

MACROH2A1 MYLK PRG4 HMGN3

2.38e-04199404M3886
CoexpressionBUSSLINGER_ESOPHAGEAL_EARLY_SUPRABASAL_CELLS

HMGB1 DEK RPL4

2.40e-0479403M40003
CoexpressionGSE10240_CTRL_VS_IL22_STIM_PRIMARY_BRONCHIAL_EPITHELIAL_CELLS_UP

TACC2 MACROH2A1 ELK3 REEP3

2.42e-04200404M302
CoexpressionGSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_ATOPIC_PATIENT_UP

KIFAP3 XRCC1 DEK HMGN3

2.42e-04200404M7077
CoexpressionGSE27786_BCELL_VS_NKTCELL_UP

PCSK1 APC XRCC1 ERCC6L

2.42e-04200404M4808
CoexpressionGSE13522_WT_VS_IFNAR_KO_SKING_T_CRUZI_Y_STRAIN_INF_UP

ELK3 MAP6 PRG4 HMGN3

2.42e-04200404M2933
CoexpressionGSE14350_IL2RB_KO_VS_WT_TREG_DN

ELK3 PRG4 HMGN3 H1-0

2.42e-04200404M3422
CoexpressionWELCSH_BRCA1_TARGETS_UP

KIFAP3 DEK HMGN3 H1-0

2.47e-04201404M5490
CoexpressionPARK_HSC_VS_MULTIPOTENT_PROGENITORS_UP

HMGB1 MACROH2A1

3.82e-0419402M1412
CoexpressionFAN_OVARY_CL16_LYMPHATIC_ENDOTHELIAL_CELL

ELK3 REEP3 HMGN3 H1-0

4.26e-04232404M41718
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_2500_k-means-cluster#4

APC HMGB1 MACROH2A1 ARHGAP35 REEP3 DEK ARHGEF7 PRDM2

1.26e-05595408Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_2500_K4
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6|World / Primary Cells by Cluster

APC KIFAP3 ANKRD12 MAP6 RPL4 SRRM4

2.01e-081993961b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal|World / Primary Cells by Cluster

APC KIFAP3 ANKRD12 MAP6 RPL4 SRRM4

2.01e-081993964bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCellILEUM-non-inflamed-(6)_ILC-(6)_ILC3|(6)_ILC / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MACROH2A1 ELK3 PHACTR2 REEP3 RPL4

8.20e-07199395ba144739f65560207303c0143e8de1e86922bebb
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CCDC168|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK1 PHACTR2 MYLK CHRM2

1.83e-05180394a407376209d80177bf7fc4200219030c83cb5f14
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

APC ANKRD12 PHACTR2 MYLK

2.08e-0518639403db813598b67b1e08f759758a1c2023396921fa
ToppCellNon-neuronal-Postmitotic-Red_blood_cells-Low_Quality-14|World / Primary Cells by Cluster

PCSK1 RPL4 SRRM4 SETBP1

2.26e-05190394feadd834d843f952aa7ced93899fd1f0868743df
ToppCellNon-neuronal-Postmitotic-Red_blood_cells-Low_Quality|World / Primary Cells by Cluster

PCSK1 RPL4 SRRM4 SETBP1

2.26e-0519039431cf1367db5c04242621f7c98a10d094bc519e31
ToppCellNon-neuronal-Postmitotic-Red_blood_cells|World / Primary Cells by Cluster

PCSK1 RPL4 SRRM4 SETBP1

2.26e-05190394f0b82334375749d917e440c493f10340c52ea13c
ToppCellB_cell_maturation-CD34+_pre-plamsa|B_cell_maturation / Lineage and Cell class

MACROH2A1 ELK3 MYLK H1-0

2.30e-051913944ee160a863d4fb9c4c9449633b9f337db8871992
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK1 MYLK AEBP1 PRG4

2.40e-051933945bee7abc550ddaa28cbb3b9ecaf6b924ab175de0
ToppCellControl-Stromal-Myofibroblast|World / Disease state, Lineage and Cell class

MYLK AEBP1 PRG4 SETBP1

2.45e-051943943c2266772c5b56e8e02a461e5193e29588028ee9
ToppCellControl-Stromal-Myofibroblast|Control / Disease state, Lineage and Cell class

MYLK AEBP1 PRG4 SETBP1

2.50e-05195394ffcf76cd72e43d8cf1058a49c76e0956065038bc
ToppCellPrimary_Visual_cortex_(V1C)|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK1 PHACTR2 CHRM2 H1-0

2.50e-0519539424dbb125565facd2de42d848471d4867c81acf80
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ELK3 ANKRD12 PHACTR2 RPL4

2.55e-05196394d4fd5513e98eec092d51199e7f054bc15a5eaa3d
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ELK3 ANKRD12 PHACTR2 RPL4

2.55e-051963943a08209210e1a8677097a78786e00062c81b1ad2
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ELK3 ANKRD12 PHACTR2 RPL4

2.55e-05196394fddc3e89e7e6b093563655c2d02e86836cfd6da5
ToppCellCOVID-19_Convalescent-CD4+_Tcm|COVID-19_Convalescent / Disease condition and Cell class

ELK3 ANKRD12 PHACTR2 RPL4

2.55e-05196394f2a5eeb1cebde2762865ab29792370b751214c4d
ToppCellCOVID-19_Convalescent-Lymphoid_T/NK-CD4+_Tcm|COVID-19_Convalescent / Disease group, lineage and cell class

ELK3 ANKRD12 PHACTR2 RPL4

2.55e-051963948caf4334ae692ce44e8fea5d606416afc5b72c00
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)

ELK3 ANKRD12 PHACTR2 RPL4

2.55e-051963947d841113a7161b017a08602d46366ac044271b34
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYLK AEBP1 PRG4 SETBP1

2.60e-0519739494a9603cbd3516fbcce871909693b88f20d41713
ToppCellCV-Moderate|CV / Virus stimulation, Condition and Cluster

HMGB1 ELK3 AEBP1 RPL4

2.60e-051973948747a57ded96175a8365f066101ce2af80c8081d
ToppCell10x3'2.3-week_14-16-Lymphocytic_B-B_lineage-pre_pro_B_progenitor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

HMGB1 MACROH2A1 DEK HMGN3

2.65e-051983948aa4149d2c1cec73cfd654db093252ec8ec5ef68
ToppCellsystemic_lupus_erythematosus-flare|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

HMGB1 ANKRD12 ASH1L EIF4G2

2.65e-051983944c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCell10x5'v1-week_12-13-Lymphocytic_B-B_lineage|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

HMGB1 MACROH2A1 AEBP1 HMGN3

2.71e-05199394ea75804c34989c99aab542e6d72617ed144819b6
ToppCell10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-pre_pro_B_progenitor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

HMGB1 MACROH2A1 DEK HMGN3

2.71e-0519939499778178e3ec121802db938db8c5475d19b43fec
ToppCell10x5'v1-week_12-13-Lymphocytic_B|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

HMGB1 MACROH2A1 AEBP1 HMGN3

2.71e-05199394713dfd8552635645db5e0b5721c64e5c9b4aa06c
ToppCellNeuron|World / Primary Cells by Cluster

KIFAP3 ANKRD12 MAP6 SRRM4

2.71e-051993941f8104fd92f04690b41d9d07ac08dc59d76bb97d
ToppCell10x5'v1-week_14-16-Lymphocytic_B-B_lineage-pre_pro_B_progenitor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

HMGB1 MACROH2A1 DEK HMGN3

2.71e-051993948daf945fc93169b0a4fa3ef9f4a87eedd52e314a
ToppCellNeuron-Postmitotic|World / Primary Cells by Cluster

KIFAP3 ANKRD12 MAP6 SRRM4

2.71e-051993941973527f8a7d4c6490d75c0d0ea153688166a08b
ToppCell10x3'2.3-week_12-13-Lymphocytic_B-B_lineage|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

HMGB1 MACROH2A1 DEK HMGN3

2.71e-05199394fe3b7d540a644dfc6beea171c809b4d1ba4e188f
ToppCellnormal_Lung-T/NK_cells-Undetermined|T/NK_cells / Location, Cell class and cell subclass

HMGB1 MACROH2A1 ERCC6L DEK

2.71e-051993944142d5b1b20212508f95841fdac4efb7655616cb
ToppCell10x3'2.3-week_12-13-Lymphocytic_B|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

HMGB1 MACROH2A1 DEK HMGN3

2.71e-05199394cdee798e3586e4e7a15de598239090a85752ea1e
ToppCell10x5'v1-week_17-19-Lymphocytic_B-B_lineage-pre_B_progenitor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

HMGB1 MACROH2A1 AEBP1 DEK

2.71e-05199394be425e9cb90a73289026b1b7cb581e1c02a8985e
ToppCellCOVID-19-COVID-19_Convalescent-Lymphocyte-T/NK-CD4+_Tcm|COVID-19_Convalescent / Disease, condition lineage and cell class

ELK3 ANKRD12 PHACTR2 RPL4

2.76e-0520039499c5abfe96d791c60ae6021ab4201851ee4afc47
ToppCellParenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

MYLK AEBP1 PRG4 SETBP1

2.76e-05200394aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-3|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MYLK AEBP1 PRG4 CHRM2

2.76e-0520039407641f476cb1a131c2a50258b88cc13bb38c8379
ToppCellParenchyma_Control_(B.)-Stromal-TX-Fibroblasts-3|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

MYLK AEBP1 PRG4 CHRM2

2.76e-05200394343fa6ba1f52d816d2e41466f674ff8360aecd81
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons|GW23 / Sample Type, Dataset, Time_group, and Cell type.

ANKRD12 ARHGAP35 SRRM4 EIF4G2

2.76e-05200394c6bbd33bca86ac7a76a7ba704b3e141237d04549
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MYLK AEBP1 PRG4 SETBP1

2.76e-05200394a510deaada669e690329183e18df02870bd204b3
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-3-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MYLK AEBP1 PRG4 CHRM2

2.76e-05200394d0c00cdd52c2e001aec9b935f4e981ba77d0386a
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Stem_cells-Stem_cells|GW09 / Sample Type, Dataset, Time_group, and Cell type.

HMGB1 MACROH2A1 DEK HMGN3

2.76e-05200394c00cc0b91baa37828895d9d6b8acbc6aa503215a
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Stem_cells|GW09 / Sample Type, Dataset, Time_group, and Cell type.

HMGB1 MACROH2A1 DEK HMGN3

2.76e-052003949e1b62a703fb7d413ce580448a1df5127c28e8a7
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MYLK AEBP1 PRG4 SETBP1

2.76e-05200394dd4228cbed8a4395166a6332e08d44d88bebe3b9
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Chromophobe-6|TCGA-Kidney / Sample_Type by Project: Shred V9

VCX2 VCX3A VCX

7.17e-0592393965a0ebf4b1ad3eaad839b96995ea6712c5d3357
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal|GW23 / Sample Type, Dataset, Time_group, and Cell type.

ANKRD12 SRRM4 EIF4G2

1.29e-041123939c3fb470708e76a8f8a3cb9aa17ab130c60fee11
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Mixed_Serous_and_Endometrioid-1|TCGA-Endometrium / Sample_Type by Project: Shred V9

VCX2 VCX3A VCX

1.39e-04115393c724e8b1fddcefdaa8d247aaff68c986538068f7
ToppCell(08)_Brush+PNEC-(2)_GFP_FOXI1|(08)_Brush+PNEC / shred by cell type by condition

APC ANKRD12 ASH1L

2.38e-04138393817e3f639604ea95adae01e8685ffaa2e0aff7a8
ToppCell(04)_Pre-ciliated-(2)_48hpi|(04)_Pre-ciliated / shred by cell type and Timepoint

DEK HMGN3 RPL4

3.60e-04159393e1f36b237e314ef6a18224eb8f3b97a612c39506
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D231|Adult / Lineage, Cell type, age group and donor

PCSK1 MYLK CHRM2

3.67e-04160393d783d29150033e9181c0e30870070268fed3fd85
ToppCellfacs-Kidney-nan-24m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AEBP1 PRG4 SRRM4

4.02e-04165393c746bb22ef52d7f7fa6ee9c37ae6bbe0ccce718e
ToppCell15-Airway-Mesenchymal-Airway_Smooth_Muscle|Airway / Age, Tissue, Lineage and Cell class

TACC2 MYLK SRRM4

4.02e-04165393531804467601e1ee1f771cffa21501f6d464ae10
ToppCell10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor|lymph-node_spleen / Manually curated celltypes from each tissue

MYLK CHRM2 H1-0

4.02e-041653937b992843bd8ef92a7a76b1d681fa84efde6f5bdd
ToppCellfacs-Kidney-nan-24m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AEBP1 PRG4 SRRM4

4.02e-041653934cdd80580d5638fd649280ba3893251c2f898f3f
ToppCelltumor_Lung-B_lymphocytes-Undetermined|tumor_Lung / Location, Cell class and cell subclass

RPL4 PRDM2 SETBP1

4.02e-041653933d010a66abac3961cc99f20b1459cf0eb0f7510d
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYLK AEBP1 CHRM2

4.09e-0416639394636dbc039f794c735960c3425e00bdd5523602
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AEBP1 PRG4 CHRM2

4.16e-04167393351f8de1fbdf742ac74f9099b254d515ab539bb2
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AEBP1 PRG4 CHRM2

4.16e-04167393c042d6cdddd0e1ddef1e3ac6f4fe23151127b0f2
ToppCellChildren_(3_yrs)-Mesenchymal-chondrocyte-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYLK AEBP1 PRG4

4.16e-04167393f4943fb5001475ddab82a0273bcbb3fa68fdd7bd
ToppCellPND14-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MACROH2A1 ERCC6L DEK

4.23e-04168393b7cd33f5da4f37b9384fc3bd3ca01fbc790accfc
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ELK3 AEBP1 HMGN3

4.31e-04169393f077e39e41fffe7672541f5b72b80faaf56c597c
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ELK3 AEBP1 HMGN3

4.38e-0417039335e3945d8a540a3e2cec1b559316265aaad023d1
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TACC2 AEBP1 SRRM4

4.38e-0417039314aa86a4f526ed6986afcb28c49225522055550c
ToppCellPND01-Endothelial-Endothelial_lymphatic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ELK3 AEBP1 HMGN3

4.38e-041703930ea625abaa25bab93b70b7000e8f90d5c0f9a0fb
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANKRD12 PHACTR2 REEP3

4.38e-0417039351dbfa07daf6f972b566f3f6abe7f46e080ec01c
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ELK3 AEBP1 HMGN3

4.38e-041703930b5ddc7d452db0a389927a367914f7d257703f7e
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-Sox9_Epi-Sox9_Epi_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HMGB1 HMGN3 H1-0

4.46e-04171393621f9da0bfa09c86fc89fd26919403e94cd56d2b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

AEBP1 PRDM2 SETBP1

4.46e-04171393a2938e56cb5749004317798dc7ac0f0c2d4d8ae0
ToppCellASK454-Epithelial-Transformed_epithelium|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

EPS15L1 REEP3 PCDH1

4.53e-041723933986f0f098ef5e096c8d9ee3d335b8404083701f
ToppCell3'_v3-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Lymphocytic-T|bone_marrow / Manually curated celltypes from each tissue

MACROH2A1 ERCC6L DEK

4.69e-041743931e289b26e2c29dbad15b712a999b96c391a26129
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMGB1 NT5C1A DEK

4.69e-04174393021ebc6ec022b992d7b25333ba0b7416371e041b
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMGB1 NT5C1A DEK

4.69e-04174393c2fc78dd6c440737ded59676961e4c7b923084ce
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HMGB1 ERCC6L HMGN3

4.69e-0417439346cbb462173a684ceb9e680f9259dc3b133763f7
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYLK AEBP1 CHRM2

4.77e-041753931799a7be623dc3bf53ba580a7c47d2619969d708
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

PCSK1 MAP6 SRRM4

4.77e-041753939941c35601134d88d1b3249c81f8b43a8fc61610
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AEBP1 CHRM2 C6orf132

4.85e-041763938e7f38de8bf68077e2138f4d06c1f55b0fd096cc
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AEBP1 CHRM2 C6orf132

4.85e-04176393ed575330a08a6748ea4b28433292c8cfd157d444
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HMGB1 ERCC6L DEK

4.93e-041773938a74f5e72de605774111057bd87a7e7e4a6385cd
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYLK CHRM2 SETBP1

4.93e-04177393b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK1 MAP6 PRG4

4.93e-04177393fd4a297e519b3959811a462d63feebff76429031
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-regulatory_T_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK1 MAP6 PRG4

4.93e-04177393e995230ef207dcd87eab4550617589016ffa9970
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

HMGB1 HMGN3 RPL4

5.01e-041783937975bf0a3146ee0efa4f547af5977e6bf0ba71fd
ToppCellB_cells-Naive_B_cells_|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

MYLK AEBP1 ARHGEF7

5.01e-0417839371ac2eca5cf13a91f86b80690748b0788392dcfc
ToppCellP28-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

AEBP1 PRG4 C6orf132

5.01e-041783931e05bc26591fea16e29bcfc5f538dda1dc427f05
ToppCellCOVID-19-Heart-VSMC|Heart / Disease (COVID-19 only), tissue and cell type

MYLK ARHGEF7 SETBP1

5.09e-04179393a69ad6912b5c10bb9f9d800f724c792341e9bab1
ToppCellCOVID-19-kidney-vSMC/Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYLK ARHGEF7 SETBP1

5.09e-04179393111b1084f73306bdeffaaf240e7dbb4f5bf33de1
ToppCell-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

AEBP1 PRG4 CHRM2

5.09e-0417939310fadbaa1b6d21cbf9f354d717cc4c225619f4fd
ToppCelldroplet-Liver-LIVER_HEP|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELK3 PHACTR2 PRDM2

5.18e-04180393423454e3390080ae03bb3cbb267255ebfe4df080
ToppCell3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-mLTo|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYLK AEBP1 SRRM4

5.18e-04180393d1c52aeceb3627e3c5fb6cc3af77e0400f9380ab
ToppCelldroplet-Liver-LIVER_HEP-30m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELK3 PHACTR2 PRDM2

5.18e-04180393dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCellCOPD-Endothelial-VE_Capillary_A|World / Disease state, Lineage and Cell class

MYLK PCDH1 CHRM2

5.26e-0418139361608123959483ff60f07d8467996853c4371b6a
ToppCellmetastatic_Brain-Fibroblasts-Myofibroblasts|metastatic_Brain / Location, Cell class and cell subclass

MYLK AEBP1 PRG4

5.26e-04181393bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK1 AEBP1 PRG4

5.35e-04182393d179b5deb07c20d49eb6c58d5a65904f8921de3a
ToppCell5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYLK AEBP1 CHRM2

5.43e-0418339361a73de857f4ae02dcba3af348f436f602b28ff2
ToppCellImmune_cells-large_pre-B.|World / Lineage and Cell class

HMGB1 MACROH2A1 HMGN3

5.43e-0418339381b5ed6ed661d2d6a9b807fefd2f0d59bd4ea77e
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYLK AEBP1 CHRM2

5.43e-04183393bc7dd6a40ec9c773d005c1a46f305d40cdd0a326
ToppCellMesenchymal_cells-Smooth_muscle|Mesenchymal_cells / Lineage and Cell class

PCSK1 MYLK PCDH1

5.52e-0418439383987abaedc26e6da477bc70d65e10b1ab1aea60
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYLK AEBP1 CHRM2

5.52e-041843937b5678718719020b52e7c2a7bd9797987defd7ff
ToppCellCOPD-Endothelial-VE_Capillary_A|COPD / Disease state, Lineage and Cell class

MYLK PCDH1 CHRM2

5.52e-041843935f4f7775d488ececf086c71441defecbee9d8a9c
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYLK AEBP1 CHRM2

5.52e-0418439354e5b63f55b8d6eccad53d389ea9c78f991e1414
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CCDC168|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK1 PHACTR2 MYLK

5.61e-041853935a0340c25196453f19e424d346efbf66d2c53ac3
DrugMethylnitronitrosoguanidine

APC HMGB1 ELK3 ABL1 MYLK DEK

6.47e-06265406ctd:D008769
DrugCamptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; PC3; HT_HG-U133A

APC TACC2 ANKRD12 ARHGEF7 PRDM2

1.54e-051804054541_DN
Drugcolcemid; Up 200; 11.7uM; MCF7; HT_HG-U133A_EA

PHF2 ANKRD12 PHACTR2 ABL1 ARHGAP35

1.99e-051904051103_UP
DrugDoxycycline hydrochloride [10592-13-9]; Down 200; 8.4uM; MCF7; HT_HG-U133A

APC MACROH2A1 XRCC1 ARHGEF7 EIF4G2

2.15e-051934053479_DN
DrugDoxazosin mesylate [77883-43-3]; Down 200; 7.4uM; MCF7; HT_HG-U133A

APC EPS15L1 ANKRD12 ARHGAP35 ASH1L

2.37e-051974054988_DN
DrugButoconazole nitrate [32872-77-1]; Down 200; 8.4uM; PC3; HT_HG-U133A

KIFAP3 EPS15L1 MYLK SETBP1 H1-0

2.37e-051974056288_DN
DrugNitrofural [59-87-0]; Down 200; 20.2uM; MCF7; HT_HG-U133A

APC KIFAP3 MACROH2A1 ARHGAP35 PRDM2

2.49e-051994055321_DN
Drugimidafenacin

MYLK CHRM2

4.49e-056402CID006433090
Diseasegallbladder cancer (is_implicated_in)

APC XRCC1

1.32e-0413392DOID:3121 (is_implicated_in)
DiseaseGlioma

APC XRCC1 MYLK

2.10e-0487393C0017638
DiseaseNeurodevelopmental Disorders

PHF2 SETBP1 ASH1L

2.55e-0493393C1535926
Diseasechronic myeloid leukemia (is_implicated_in)

ABL1 XRCC1

3.52e-0421392DOID:8552 (is_implicated_in)
Diseasetransitional cell carcinoma (is_implicated_in)

APC XRCC1

3.87e-0422392DOID:2671 (is_implicated_in)
Diseaseproprotein convertase subtilisin/kexin type 9 measurement

PHACTR2 REEP3

3.87e-0422392EFO_0009312
Diseasecolorectal cancer (is_implicated_in)

APC ABL1 XRCC1

5.52e-04121393DOID:9256 (is_implicated_in)
DiseaseMyeloid Leukemia, Chronic

ABL1 SETBP1

6.76e-0429392C0023473
DiseaseMalignant neoplasm of liver

APC ABL1 ASH1L

8.78e-04142393C0345904
DiseaseLiver neoplasms

APC ABL1 ASH1L

8.78e-04142393C0023903
DiseaseMesothelioma

APC XRCC1

1.35e-0341392C0025500
Diseaserevision of total hip arthroplasty, aseptic loosening

VCX2 VCX3B

1.42e-0342392EFO_0010725, EFO_0020973
DiseaseL2 Acute Lymphoblastic Leukemia

ABL1 XRCC1

2.00e-0350392C0023453
DiseaseChildhood Acute Lymphoblastic Leukemia

ABL1 XRCC1

2.16e-0352392C0023452

Protein segments in the cluster

PeptideGeneStartEntry
KSKQDTPALPPKKPA

EPS15L1

771

Q9UBC2
TCPPSKSSKTKPKKL

ASH1L

226

Q9NR48
NLAPKKKPKSPKPQN

NT5C1A

36

Q9BXI3
PKATKKPKEKPPKAT

AEBP1

136

Q8IUX7
SKAPTKKPKATPVKK

H1-0

131

P07305
PPAKKAKSPSQKKPV

MACROH2A1

131

O75367
VKMTKQPAKKKPPPS

CHRM2

366

P08172
KPVSPKSGTLKSPPK

ARHGEF7

246

Q14155
KPKPKSSPASKDTRP

ANKRD12

1051

Q6UB98
TVKKKPAPKTPPKAA

MYLK

1221

Q15746
PPKVEKPSVQSSKPK

MAP6

371

Q96JE9
KKKFKDPNAPKRPPS

HMGB1

86

P09429
SKGKKSKSPKPVKPV

PCDH1

911

Q08174
PPKPEPKPRKTSAKK

HMGN3

36

Q15651
KPKPKKSPVPPKGAT

PHACTR2

166

O75167
KPAPEKKPAEKKPTT

RPL4

406

P36578
IQEKPAKTSKKPPPS

EIF4G2

526

P78344
TKTPKSSSPALKPKP

C6orf132

431

Q5T0Z8
PKPSGKPLPKSKKTC

DEK

186

P35659
KKKKTAPTPPKRSSS

ABL1

606

P00519
KTKSPSLPPKAKKPK

ELK3

281

P41970
KEKKEKSSKPKDPPP

KIFAP3

106

Q92845
KKKCPKLNKPQPQPS

ERCC6L

741

Q2NKX8
FSCPKKPLSPPKKKV

PRDM2

1476

Q13029
KPLSPPKKKVSHSSK

PRDM2

1481

Q13029
PKKKKTGAPPAPSCK

REXO1

376

Q8N1G1
PSPSDPKKKTTKVAK

VCX3A

26

Q9NNX9
PSPSDPKKKTTKVAK

VCX3B

26

Q9H321
TVKMPKPSKIPKPPK

PHF2

496

O75151
KKKFKDPNAPKRPPS

HMGB1P1

86

B2RPK0
QPLPEAKKKSKPAPS

REEP3

171

Q6NUK4
TKKPKPKPRPSITKA

ARHGAP35

1226

Q9NRY4
STTKRSPKPPNKKKT

PRG4

131

Q92954
ATTPKPQKPTKAPKK

PRG4

1016

Q92954
PQKPTKAPKKPTSTK

PRG4

1021

Q92954
DGKKKKPTSPVKPIP

APC

1766

P25054
PSPSDPKKKTTKVAK

VCX2

26

Q9H322
TPPPSSRGKKKKKKS

SRRM4

101

A7MD48
RPPSLKKKQTTKKPT

TACC2

2131

O95359
PSPSDPKKKTTKVAK

VCX

26

Q9H320
PKLPQKQPQTKTKPT

XRCC1

426

P18887
PEPPTVGSKKKSSKK

SETBP1

326

Q9Y6X0
SKNSPPKQSPKKSPS

PCSK1

676

P29120