Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	immunoglobulin receptor binding	NCR3LG1 IGHG2 IGHG4	1.48e-05	21	46	3	GO:0034987
GeneOntologyMolecularFunction	Fc-gamma receptor I complex binding	IGHG2 IGHG4	1.08e-04	7	46	2	GO:0034988
GeneOntologyMolecularFunction	nodal binding	CFC1B CFC1	1.44e-04	8	46	2	GO:0038100
GeneOntologyMolecularFunction	activin receptor binding	CFC1B CFC1	4.64e-04	14	46	2	GO:0070697
GeneOntologyBiologicalProcess	left lung morphogenesis	CFC1B CFC1	3.04e-05	4	47	2	GO:0060460
GeneOntologyBiologicalProcess	left lung development	CFC1B CFC1	5.06e-05	5	47	2	GO:0060459
GeneOntologyBiologicalProcess	complement activation, classical pathway	NCR3LG1 IGHG2 IGHG4	1.38e-04	44	47	3	GO:0006958
GeneOntologyBiologicalProcess	positive regulation of type I hypersensitivity	IGHG2 IGHG4	1.41e-04	8	47	2	GO:0001812
GeneOntologyBiologicalProcess	regulation of type I hypersensitivity	IGHG2 IGHG4	1.81e-04	9	47	2	GO:0001810
GeneOntologyBiologicalProcess	positive regulation of type II hypersensitivity	IGHG2 IGHG4	2.26e-04	10	47	2	GO:0002894
GeneOntologyBiologicalProcess	positive regulation of type IIa hypersensitivity	IGHG2 IGHG4	2.26e-04	10	47	2	GO:0001798
GeneOntologyBiologicalProcess	type I hypersensitivity	IGHG2 IGHG4	2.26e-04	10	47	2	GO:0016068
GeneOntologyBiologicalProcess	regulation of type II hypersensitivity	IGHG2 IGHG4	2.76e-04	11	47	2	GO:0002892
GeneOntologyBiologicalProcess	regulation of type IIa hypersensitivity	IGHG2 IGHG4	2.76e-04	11	47	2	GO:0001796
GeneOntologyBiologicalProcess	humoral immune response mediated by circulating immunoglobulin	NCR3LG1 IGHG2 IGHG4	3.82e-04	62	47	3	GO:0002455
GeneOntologyBiologicalProcess	antibody-dependent cellular cytotoxicity	IGHG2 IGHG4	3.90e-04	13	47	2	GO:0001788
GeneOntologyBiologicalProcess	positive regulation of hypersensitivity	IGHG2 IGHG4	5.24e-04	15	47	2	GO:0002885
GeneOntologyBiologicalProcess	type IIa hypersensitivity	IGHG2 IGHG4	5.24e-04	15	47	2	GO:0001794
GeneOntologyBiologicalProcess	type II hypersensitivity	IGHG2 IGHG4	5.24e-04	15	47	2	GO:0002445
GeneOntologyBiologicalProcess	complement activation	NCR3LG1 IGHG2 IGHG4	5.45e-04	70	47	3	GO:0006956
GeneOntologyCellularComponent	immunoglobulin complex, circulating	NCR3LG1 IGHG2 IGHG4	7.09e-06	17	47	3	GO:0042571
GeneOntologyCellularComponent	IgG immunoglobulin complex	IGHG2 IGHG4	4.43e-04	14	47	2	GO:0071735
MousePheno	total anomalous pulmonary venous connection, intracardiac	CFC1B CFC1	6.45e-06	2	36	2	MP:0010443
MousePheno	unbalanced complete common atrioventricular canal	CFC1B CFC1	3.86e-05	4	36	2	MP:0011673
MousePheno	absent memory B cells	IGHG2 IGHG4	3.86e-05	4	36	2	MP:0008094
MousePheno	total anomalous pulmonary venous connection	CFC1B CFC1	3.86e-05	4	36	2	MP:0010441
MousePheno	postnatal lethality, complete penetrance	CFC1B SENP1 ATP7A NEB BCLAF1 BTBD7 CFC1	1.18e-04	445	36	7	MP:0011085
MousePheno	superior-inferior ventricles	CFC1B CFC1	1.34e-04	7	36	2	MP:0011254
MousePheno	accessory spleen	CFC1B CFC1	2.30e-04	9	36	2	MP:0003342
MousePheno	decreased memory B cell number	IGHG2 IGHG4	2.30e-04	9	36	2	MP:0008729
MousePheno	decreased IgG2c level	IGHG2 IGHG4	3.50e-04	11	36	2	MP:0008897
MousePheno	abnormal memory B cell number	IGHG2 IGHG4	3.50e-04	11	36	2	MP:0008093
MousePheno	d-loop transposition of the great arteries	CFC1B CFC1	4.94e-04	13	36	2	MP:0011665
MousePheno	abnormal direction of embryo turning	CFC1B CFC1	4.94e-04	13	36	2	MP:0004190
MousePheno	abnormal awl hair morphology	ATP7A BRCA1	4.94e-04	13	36	2	MP:0000400
MousePheno	heart right ventricle hypoplasia	CFC1B CFC1	5.75e-04	14	36	2	MP:0010422
MousePheno	abnormal memory B cell morphology	IGHG2 IGHG4	5.75e-04	14	36	2	MP:0002440
MousePheno	abnormal plasma cell differentiation	IGHG2 IGHG4	6.63e-04	15	36	2	MP:0008099
MousePheno	anomalous pulmonary venous connection	CFC1B CFC1	6.63e-04	15	36	2	MP:0010440
Domain	CFC	CFC1B CFC1	1.86e-05	3	47	2	PF09443
Domain	Cryptic/Cripto_CFC-dom	CFC1B CFC1	1.86e-05	3	47	2	IPR019011
Domain	C1-set	NCR3LG1 IGHG2 IGHG4	3.39e-04	54	47	3	PF07654
Domain	IGc1	NCR3LG1 IGHG2 IGHG4	3.77e-04	56	47	3	SM00407
Domain	Ig_C1-set	NCR3LG1 IGHG2 IGHG4	4.18e-04	58	47	3	IPR003597
Domain	Ig/MHC_CS	NCR3LG1 IGHG2 IGHG4	4.18e-04	58	47	3	IPR003006
Domain	IG_MHC	NCR3LG1 IGHG2 IGHG4	4.62e-04	60	47	3	PS00290
Domain	WD40_repeat_dom	ZNF106 WDR76 EML4 SON	6.53e-03	297	47	4	IPR017986
Domain	-	ZNF106 WDR76 EML4 SON	9.69e-03	333	47	4	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	ZNF106 WDR76 EML4 SON	9.89e-03	335	47	4	IPR015943
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	GNL2 MCM3 NIFK COPG2 SETX BRCA1 SRFBP1 SPEN EML4 BCLAF1 SON	4.41e-08	954	47	11	36373674
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	GNL2 MCM3 NIFK ZNF106 DDX31 WDR76 SPEN SON	7.33e-08	410	47	8	26949251
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	CASP8AP2 NIFK ZNF106 NKTR ASXL2 SETX BRCA1 SRFBP1 WDR76 SPEN BCLAF1 SON	1.05e-07	1294	47	12	30804502
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	MUC16 MCM3 COPG2 SETX ATP7A PEAK1 BRCA1 SPEN BCLAF1	8.44e-07	777	47	9	35844135
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	BDP1 SENP1 SETX DDX31 BRCA1 SON	1.09e-06	250	47	6	33536335
Pubmed	BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair.	SETX BRCA1	1.79e-06	2	47	2	25699710
Pubmed	The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer.	CFC1B CFC1	1.79e-06	2	47	2	11174844
Pubmed	Identification of differentially expressed genes in mouse development using differential display and in situ hybridization.	CFC1B CFC1	1.79e-06	2	47	2	11327798
Pubmed	Subtractive hybridization identifies chick-cripto, a novel EGF-CFC ortholog expressed during gastrulation, neurulation and early cardiogenesis.	CFC1B CFC1	1.79e-06	2	47	2	11024280
Pubmed	Identification of differentially methylated BRCA1 and CRISP2 DNA regions as blood surrogate markers for cardiovascular disease.	CRISP2 BRCA1	1.79e-06	2	47	2	28698603
Pubmed	Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects.	CFC1B CFC1	1.79e-06	2	47	2	11062482
Pubmed	Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs.	CFC1B CFC1	5.36e-06	3	47	2	16835440
Pubmed	Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains.	IGHG2 IGHG4	1.07e-05	4	47	2	6283537
Pubmed	Somatic mutation in genes for the variable portion of the immunoglobulin heavy chain.	IGHG2 IGHG4	1.07e-05	4	47	2	6801765
Pubmed	Sequence analysis of cloned cDNA encoding part of an immunoglobulin heavy chain.	IGHG2 IGHG4	1.07e-05	4	47	2	113776
Pubmed	Highly specific anti-estradiol antibodies: structural characterisation and binding diversity.	IGHG2 IGHG4	1.07e-05	4	47	2	11812141
Pubmed	Multiple amino acid substitutions between murine gamma 2a heavy chain Fc regions of Ig1a and Ig1b allotypic forms.	IGHG2 IGHG4	1.07e-05	4	47	2	6794027
Pubmed	Immunoglobulin diversity: analysis of the germ-line VH gene repertoire of the murine anti-GAT response.	IGHG2 IGHG4	1.07e-05	4	47	2	6306571
Pubmed	Further evidence that BALB/c and C57BL/6 gamma 2a genes originate from two distinct isotypes.	IGHG2 IGHG4	1.07e-05	4	47	2	2510996
Pubmed	Spontaneous deletions in Ig heavy chain genes: flanking sequences influence splice site selection.	IGHG2 IGHG4	1.07e-05	4	47	2	1754385
Pubmed	Sialic acid residues are essential for the anaphylactic activity of murine IgG1 antibodies.	IGHG2 IGHG4	1.07e-05	4	47	2	19050247
Pubmed	The molecular and biochemical characterization of mutant monoclonal antibodies with increased antigen binding.	IGHG2 IGHG4	1.07e-05	4	47	2	1672339
Pubmed	Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin.	IGHG2 IGHG4	1.07e-05	4	47	2	6407005
Pubmed	An autoimmune disease variant of IgG1 modulates B cell activation and differentiation.	IGHG2 IGHG4	1.07e-05	4	47	2	30287618
Pubmed	Switch transcripts in immunoglobulin class switching.	IGHG2 IGHG4	1.07e-05	4	47	2	7892607
Pubmed	Determination of the primary structure of a mouse G2a immunoglobulin. Identification of the disulfide bridges.	IGHG2 IGHG4	1.07e-05	4	47	2	4565406
Pubmed	Recognition of a cell-surface oligosaccharide of pathogenic Salmonella by an antibody Fab fragment.	IGHG2 IGHG4	1.07e-05	4	47	2	1713710
Pubmed	Structure of the constant and 3' untranslated regions of the murine Balb/c gamma 2a heavy chain messenger RNA.	IGHG2 IGHG4	1.07e-05	4	47	2	6777755
Pubmed	The roles of gamma 1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses.	IGHG2 IGHG4	1.07e-05	4	47	2	9103199
Pubmed	Gene conversion and polymorphism: generation of mouse immunoglobulin gamma 2a chain alleles by differential gene conversion by gamma 2b chain gene.	IGHG2 IGHG4	1.07e-05	4	47	2	6297797
Pubmed	Evolution of immunoglobulin subclasses. Primary structure of a murine myeloma gamma1 chain.	IGHG2 IGHG4	1.07e-05	4	47	2	98524
Pubmed	IgG1 protects against renal disease in a mouse model of cryoglobulinaemia.	IGHG2 IGHG4	1.07e-05	4	47	2	25363774
Pubmed	Mutational deglycosylation of the Fc portion of immunoglobulin G causes O-sulfation of tyrosine adjacently preceding the originally glycosylated site.	IGHG2 IGHG4	1.07e-05	4	47	2	20621099
Pubmed	Immunoglobulin heavy constant gamma 1 silencing decreases tonicity-responsive enhancer-binding protein expression to alleviate diabetic nephropathy.	IGHG2 IGHG4	1.07e-05	4	47	2	38268239
Pubmed	Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98).	IGHG2 IGHG4	1.07e-05	4	47	2	12414967
Pubmed	Gene segments encoding transmembrane carboxyl termini of immunoglobulin gamma chains.	IGHG2 IGHG4	1.07e-05	4	47	2	6799207
Pubmed	Comparison of mouse immunoglobulin gamma 2a and gamma 2b chain genes suggests that exons can be exchanged between genes in a multigenic family.	IGHG2 IGHG4	1.07e-05	4	47	2	6787604
Pubmed	Shutdown of class switch recombination by deletion of a switch region control element.	IGHG2 IGHG4	1.07e-05	4	47	2	8438159
Pubmed	Passive anaphylaxis in mice with gamma-G antibodies. V. Competitive effects of different immunoglobulins and inhibition of reactions with antiglobulin sera.	IGHG2 IGHG4	1.07e-05	4	47	2	4098598
Pubmed	Mouse immunoglobulin genes: a bacterial plasmid containing the entire coding sequence for a pre-gamma 2a heavy chain.	IGHG2 IGHG4	1.07e-05	4	47	2	6253932
Pubmed	Immunoglobulin gamma 1 heavy chain gene: structural gene sequences cloned in a bacterial plasmid.	IGHG2 IGHG4	1.07e-05	4	47	2	6769752
Pubmed	Cripto in tumors and embryo development.	CFC1B CFC1	1.07e-05	4	47	2	11825688
Pubmed	Mouse immunoglobulin allotypes: post-duplication divergence of gamma 2a and gamma 2b chain genes.	IGHG2 IGHG4	1.07e-05	4	47	2	6803173
Pubmed	Multiple differences between the nucleic acid sequences of the IgG2aa and IgG2ab alleles of the mouse.	IGHG2 IGHG4	1.07e-05	4	47	2	6170065
Pubmed	Linkage of the four gamma subclass heavy chain genes.	IGHG2 IGHG4	1.07e-05	4	47	2	6264445
Pubmed	Distinction of the memory B cell response to cognate antigen versus bystander inflammatory signals.	IGHG2 IGHG4	1.07e-05	4	47	2	19703988
Pubmed	Sequences near the 3' secretion-specific polyadenylation site influence levels of secretion-specific and membrane-specific IgG2b mRNA in myeloma cells.	IGHG2 IGHG4	1.07e-05	4	47	2	2878362
Pubmed	IgG1 deficiency exacerbates experimental autoimmune myasthenia gravis in BALB/c mice.	IGHG2 IGHG4	1.07e-05	4	47	2	25867470
Pubmed	Sequence of the gamma 2b membrane 3' untranslated region: polya site determination and comparison to the gamma 2a membrane 3' untranslated region.	IGHG2 IGHG4	1.07e-05	4	47	2	1542303
Pubmed	Switch of CD4+ T cell differentiation from Th2 to Th1 by treatment with cathepsin B inhibitor in experimental leishmaniasis.	IGHG2 IGHG4	1.07e-05	4	47	2	9725203
Pubmed	Nucleotide sequences of all the gamma gene loci of murine immunoglobulin heavy chains.	IGHG2 IGHG4	1.07e-05	4	47	2	9126488
Pubmed	Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.	IGHG2 IGHG4	1.07e-05	4	47	2	6767246
Pubmed	Determination of the interface of a large protein complex by transferred cross-saturation measurements.	IGHG2 IGHG4	1.07e-05	4	47	2	12051834
Pubmed	The gamma 1 heavy chain gene includes all of the cis-acting elements necessary for expression of properly regulated germ-line transcripts.	IGHG2 IGHG4	1.07e-05	4	47	2	8683112
Pubmed	The IL-4 induced increase in the frequency of resting murine splenic B cells expressing germline Ig heavy chain gamma 1 transcripts correlates with subsequent switching to IgG1.	IGHG2 IGHG4	1.07e-05	4	47	2	8452816
Pubmed	Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse.	IGHG2 IGHG4	1.07e-05	4	47	2	807855
Pubmed	Identification of a gene locus for gamma-G-1 immunoglobulin H chains and its linkage to the H chain chromosome region in the mouse.	IGHG2 IGHG4	1.07e-05	4	47	2	4166666
Pubmed	Multiple B-cell epitope vaccine induces a Staphylococcus enterotoxin B-specific IgG1 protective response against MRSA infection.	IGHG2 IGHG4	1.07e-05	4	47	2	26201558
Pubmed	Nucleotide sequence of a human immunoglobulin C gamma 4 gene.	IGHG2 IGHG4	1.07e-05	4	47	2	6299662
Pubmed	Molecular cloning of mouse immunoglobulin heavy chain messenger ribonucleic acids coding for mu, alpha, gamma 1, gamma 2a, and gamma 3 chains.	IGHG2 IGHG4	1.07e-05	4	47	2	6249338
Pubmed	Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes.	IGHG2 IGHG4	1.07e-05	4	47	2	6804948
Pubmed	mRNA for surface immunoglobulin gamma chains encodes a highly conserved transmembrane sequence and a 28-residue intracellular domain.	IGHG2 IGHG4	1.07e-05	4	47	2	6804950
Pubmed	Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses.	IGHG2 IGHG4	1.07e-05	4	47	2	19592272
Pubmed	Attenuation of Trypanosoma brucei is associated with reduced immunosuppression and concomitant production of Th2 lymphokines.	IGHG2 IGHG4	1.07e-05	4	47	2	10720538
Pubmed	Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1.	CFC1B CFC1	1.07e-05	4	47	2	9576836
Pubmed	Determination of the primary structure of a mouse IgG2a immunoglobulin:amino-acid sequence of the Fc fragment. Implications for the evolution of immunoglobulin structure and function.	IGHG2 IGHG4	1.07e-05	4	47	2	4831970
Pubmed	Nucleotide sequences of class-switch recombination region of the mouse immunoglobulin gamma 2b-chain gene.	IGHG2 IGHG4	1.07e-05	4	47	2	7439686
Pubmed	Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region.	IGHG2 IGHG4	1.07e-05	4	47	2	24752300
Pubmed	Variable-region-identical antibodies differing in isotype demonstrate differences in fine specificity and idiotype.	IGHG2 IGHG4	1.07e-05	4	47	2	15699144
Pubmed	On immunoglobulin heavy chain gene switching: two gamma 2b genes are rearranged via switch sequences in MPC-11 cells but only one is expressed.	IGHG2 IGHG4	1.07e-05	4	47	2	6278424
Pubmed	An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment.	IGHG2 IGHG4	1.07e-05	4	47	2	35133976
Pubmed	Restriction fragment length polymorphism and evolution of the mouse immunoglobulin constant region gamma loci.	IGHG2 IGHG4	1.07e-05	4	47	2	8099342
Pubmed	Sequence and polyadenylation site determination of the murine immunoglobulin gamma 2a membrane 3' untranslated region.	IGHG2 IGHG4	1.07e-05	4	47	2	2513486
Pubmed	Increased number of T cells and exacerbated inflammatory pathophysiology in a human IgG4 knock-in MRL/lpr mouse model.	IGHG2 IGHG4	1.07e-05	4	47	2	36763580
Pubmed	Ubiquitination of IgG1 cytoplasmic tail modulates B-cell signalling and activation.	IGHG2 IGHG4	1.07e-05	4	47	2	32006024
Pubmed	Strong antigenic selection shaping the immunoglobulin heavy chain repertoire of B-1a lymphocytes in lambda 2(315) transgenic mice.	IGHG2 IGHG4	1.07e-05	4	47	2	12209645
Pubmed	Independent immunoglobulin class-switch events occurring in a single myeloma cell line.	IGHG2 IGHG4	1.07e-05	4	47	2	3921826
Pubmed	Sequence of the cloned gene for the constant region of murine gamma 2b immunoglobulin heavy chain.	IGHG2 IGHG4	1.07e-05	4	47	2	117549
Pubmed	Cloning immunoglobulin gamma 2b chain gene of mouse: characterization and partial sequence determination.	IGHG2 IGHG4	1.07e-05	4	47	2	116231
Pubmed	Role of the EGF-CFC gene cripto in cell differentiation and embryo development.	CFC1B CFC1	1.07e-05	4	47	2	11992720
Pubmed	The complete nucleotide sequence of mouse immunoglobin gamma 2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer.	IGHG2 IGHG4	1.07e-05	4	47	2	6262729
Pubmed	Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid.	IGHG2 IGHG4	1.07e-05	4	47	2	26683050
Pubmed	Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a.	IGHG2 IGHG4	1.07e-05	4	47	2	25451975
Pubmed	Complete nucleotide sequence of immunoglobulin gamma2b chain gene cloned from newborn nouse DNA.	IGHG2 IGHG4	1.07e-05	4	47	2	6766534
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	GNL2 NIFK NKTR SETX DDX31 SRFBP1 WDR76 EML4 BCLAF1 SON	1.20e-05	1371	47	10	36244648
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	GNL2 ZNF567 SETX DDX31 BRCA1 WDR76 SPEN	1.65e-05	608	47	7	36089195
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ASXL2 SPEN BTBD7 DOCK9 RAB3GAP2 SON	1.77e-05	407	47	6	12693553
Pubmed	Preneoplastic somatic mutations including MYD88L265P in lymphoplasmacytic lymphoma.	IGHG2 IGHG4	1.78e-05	5	47	2	35044826
Pubmed	Exon shuffling generates an immunoglobulin heavy chain gene.	IGHG2 IGHG4	1.78e-05	5	47	2	6769120
Pubmed	Chromosomal location of the structural gene cluster encoding murine immunoglobulin heavy chains.	IGHG2 IGHG4	1.78e-05	5	47	2	6770027
Pubmed	Sequential class switching is required for the generation of high affinity IgE antibodies.	IGHG2 IGHG4	1.78e-05	5	47	2	22249450
Pubmed	Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences.	IGHG2 IGHG4	1.78e-05	5	47	2	6421489
Pubmed	The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program.	IGHG2 IGHG4	1.78e-05	5	47	2	26620759
Pubmed	Expression of NrasQ61R and MYC transgene in germinal center B cells induces a highly malignant multiple myeloma in mice.	IGHG2 IGHG4	1.78e-05	5	47	2	32640012
Pubmed	Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies.	IGHG2 IGHG4	1.78e-05	5	47	2	7704573
Pubmed	A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation.	CFC1B CFC1	1.78e-05	5	47	2	9053319
Pubmed	Channel catfish soluble FcmuR binds conserved linear epitopes present on Cmu3 and Cmu4.	IGHG2 IGHG4	1.78e-05	5	47	2	20031218
Pubmed	Human and murine immunoglobulin expression vector cassettes.	IGHG2 IGHG4	1.78e-05	5	47	2	11257305
Pubmed	Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis.	IGHG2 IGHG4	1.78e-05	5	47	2	32229726
Pubmed	Brg1 Supports B Cell Proliferation and Germinal Center Formation Through Enhancer Activation.	IGHG2 IGHG4	1.78e-05	5	47	2	34539636
Interaction	NUP43 interactions	GNL2 CASP8AP2 NIFK SENP1 NKTR ASXL2 SETX DDX31 BRCA1 SPEN BCLAF1 RAB3GAP2 SON	6.36e-10	625	45	13	int:NUP43
Interaction	SNRNP40 interactions	GNL2 CASP8AP2 NIFK SENP1 NKTR SETX DDX31 BRCA1 SPEN PRPF40B BCLAF1 SON	9.93e-09	637	45	12	int:SNRNP40
Interaction	SMC5 interactions	GNL2 MCM3 NIFK COPG2 SETX BRCA1 SRFBP1 SPEN EML4 BCLAF1 SON	9.11e-06	1000	45	11	int:SMC5
Interaction	MKI67 interactions	GNL2 MCM3 NIFK ZNF106 DDX31 BRCA1 WDR76 SPEN SON	1.09e-05	648	45	9	int:MKI67
Interaction	NLE1 interactions	GNL2 NIFK SENP1 DDX31 SPEN SON	1.11e-05	228	45	6	int:NLE1
Interaction	MAGEB2 interactions	GNL2 NIFK NKTR DDX31 BRCA1 SRFBP1 WDR76	1.13e-05	349	45	7	int:MAGEB2
Interaction	UBE2E2 interactions	ASXL2 BRCA1 SPEN UBOX5	6.20e-05	96	45	4	int:UBE2E2
Interaction	DDX23 interactions	GNL2 NIFK NKTR DDX31 BRCA1 SRFBP1 BCLAF1	8.63e-05	480	45	7	int:DDX23
Interaction	RHBDD1 interactions	COPG2 MYLK IGHG2 BCLAF1 IGHG4 RAB3GAP2	1.14e-04	346	45	6	int:RHBDD1
Interaction	SRSF6 interactions	GNL2 NIFK NKTR DDX31 SPEN BCLAF1 SON	1.15e-04	503	45	7	int:SRSF6
Interaction	SSRP1 interactions	MCM3 SETX BRCA1 SRFBP1 WDR76 CCDC82 BCLAF1 SON	1.21e-04	685	45	8	int:SSRP1
Interaction	IGHV4-31 interactions	IGHG2 IGHG4	1.35e-04	8	45	2	int:IGHV4-31
Interaction	MCM10 interactions	GNL2 MCM3 NIFK BRCA1	1.67e-04	124	45	4	int:MCM10
Interaction	SLFN11 interactions	BDP1 SENP1 SETX DDX31 BRCA1 SON	1.79e-04	376	45	6	int:SLFN11
Cytoband	9q34.13	SETX DDX31	2.13e-04	21	47	2	9q34.13
Cytoband	2q21.1	CFC1B CFC1	1.63e-03	58	47	2	2q21.1
Coexpression	GSE25146_UNSTIM_VS_HELIOBACTER_PYLORI_LPS_STIM_AGS_CELL_DN	GNL2 BDP1 NKTR EML4 BCLAF1 DOCK9	4.48e-07	166	46	6	M8129
Coexpression	HAMAI_APOPTOSIS_VIA_TRAIL_UP	BDP1 CASP8AP2 NKTR SETX BRCA1 BCLAF1 BTBD7 SON	1.66e-05	656	46	8	M18979
Coexpression	GSE13411_NAIVE_VS_MEMORY_BCELL_UP	CRISP2 NEB WDR76 CHN2 CCDC82	2.15e-05	192	46	5	M3245
Coexpression	GSE3982_BASOPHIL_VS_TH1_UP	ZNF106 ZNF280B SPEN BCLAF1 BTBD7	2.55e-05	199	46	5	M5564
Coexpression	GSE17186_CD21LOW_VS_CD21HIGH_TRANSITIONAL_BCELL_UP	CASS4 COPG2 ATP7A SASH1 BRCA1	2.62e-05	200	46	5	M7168
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	BDP1 ASXL2 CDV3 SETX SPEN EML4 BCLAF1 DOCK9 RAB3GAP2 APBB1IP SON	4.12e-05	1492	46	11	M40023
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	CASP8AP2 ASXL2 SETX MYLK SRFBP1 EML4	4.29e-08	186	47	6	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BDP1 NKTR CDV3 SETX BCLAF1 SON	6.60e-08	200	47	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SETX MYLK SASH1 S1PR1 DOCK9	2.18e-06	200	47	5	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	COVID-19_Moderate-multiplets\|World / disease group, cell group and cell class	NKTR EML4 IGHG2 IGHG4	2.21e-05	156	47	4	afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CASP8AP2 MCM3 WDR76 APBB1IP	2.26e-05	157	47	4	eea53cf8d8a607264e1ee00b7a97c94bcf2ac80d
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASP8AP2 CCDC82 BCLAF1 BTBD7	3.70e-05	178	47	4	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	COPD-Endothelial-VE_Capillary_A\|World / Disease state, Lineage and Cell class	MYLK SASH1 S1PR1 DOCK9	3.95e-05	181	47	4	61608123959483ff60f07d8467996853c4371b6a
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASP8AP2 SETX PEAK1 EML4	4.03e-05	182	47	4	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASP8AP2 SETX PEAK1 EML4	4.03e-05	182	47	4	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	COPD-Endothelial-VE_Capillary_A\|COPD / Disease state, Lineage and Cell class	MYLK SASH1 S1PR1 DOCK9	4.21e-05	184	47	4	5f4f7775d488ececf086c71441defecbee9d8a9c
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 SETX EML4 BCLAF1	4.21e-05	184	47	4	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	10x5'-GI_small-bowel-Lymphocytic_B-GC_B_(I)\|GI_small-bowel / Manually curated celltypes from each tissue	MCM3 BRCA1 WDR76 IGHG2	4.48e-05	187	47	4	a92cade2a835f5fce8de1e14650af8cdd818c296
ToppCell	Control-Endothelial-VE_Capillary_A\|Control / Disease state, Lineage and Cell class	MYLK SASH1 S1PR1 DOCK9	4.48e-05	187	47	4	54d7588172ac145ff5045ad9771636729ca3f0ca
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	NKTR SPEN EML4 BCLAF1	4.58e-05	188	47	4	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	COPD-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	CASS4 ZNF106 PEAK1 MYLK	4.97e-05	192	47	4	62904f94dfce430456f05066522cbf9bd29f4d7e
ToppCell	control-Lymphoid-CTL\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SETX CHN2 BCLAF1 SON	5.07e-05	193	47	4	89d407a88b5956559a589425b89b3eb8dc78e1dd
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BDP1 S1PR1 BCLAF1 SON	5.17e-05	194	47	4	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CASP8AP2 MCM3 BRCA1 WDR76	5.27e-05	195	47	4	cec7df321f372d05c94f97d6bb18891a5cc3dec3
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CASP8AP2 MCM3 BRCA1 WDR76	5.27e-05	195	47	4	56d8734d020b3da08a5aa9e67999706a9e023a99
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CASP8AP2 MCM3 BRCA1 WDR76	5.27e-05	195	47	4	b65463a804fed2d9a3be9e528ca8b9c98469bc86
ToppCell	COVID-19_Severe\|World / Disease condition and Cell class	ZNF106 CDV3 IGHG2 IGHG4	5.38e-05	196	47	4	450ac2aff89c5ca73b8bfbc80663e03be066931f
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CASP8AP2 MCM3 BRCA1 WDR76	5.38e-05	196	47	4	df366d76ea55f49e349d622effa57c1535df8400
ToppCell	Transverse-B_cell-B_cell_IgG_Plasma\|B_cell / Region, Cell class and subclass	MUC16 SENP1 IGHG2 IGHG4	5.49e-05	197	47	4	a0a096e8e80763a92d5d7396eb678a4587771a3a
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYLK SASH1 S1PR1 DOCK9	5.49e-05	197	47	4	86591849476b3925857a82b6913f65e74df200c1
ToppCell	cellseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYLK SASH1 S1PR1 DOCK9	5.71e-05	199	47	4	9364199c5b4540ce2e14341fd9d504b695f8249d
ToppCell	medial-2-Endothelial-Capillary_Aerocyte\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYLK SASH1 S1PR1 DOCK9	5.71e-05	199	47	4	c5048b31649a0b7eddcd481b0458ed96508f5561
ToppCell	medial-Endothelial-Capillary_Aerocyte\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYLK SASH1 S1PR1 DOCK9	5.71e-05	199	47	4	84e30c39c2f050aa64af167999824c1cba32ba05
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MYLK SASH1 S1PR1 DOCK9	5.71e-05	199	47	4	7ed541309808f15d65a9c4b26be2050e077539e6
ToppCell	COVID-19_Moderate\|World / disease group, cell group and cell class	NKTR EML4 IGHG2 IGHG4	5.71e-05	199	47	4	952fac67588ad5676f5939e3c7f8bac803c27064
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MYLK SASH1 S1PR1 DOCK9	5.71e-05	199	47	4	1621ce2968f3100e4c39e0ef8293232a5d76c614
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MYLK SASH1 S1PR1 DOCK9	5.71e-05	199	47	4	14a7c4cf4bb3d43fd32ec9cc74f6625b225ffaa1
ToppCell	343B-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CASS4 ZNF106 PEAK1 MYLK	5.71e-05	199	47	4	212e89d097753790061310373a1fafba773488b6
ToppCell	medial-Endothelial-Capillary_Aerocyte-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYLK SASH1 S1PR1 DOCK9	5.71e-05	199	47	4	f1039d1ab498fc58f0feba545df05833c235db74
ToppCell	distal-Endothelial-Capillary_Aerocyte-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYLK SASH1 S1PR1 DOCK9	5.71e-05	199	47	4	9021f4be004efd51bb3658e5bbff53589356b3df
ToppCell	343B-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CASS4 ZNF106 PEAK1 MYLK	5.71e-05	199	47	4	14b676aa289c0578a37be32cec3ea285c79d97cc
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SETX SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SETX SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	b7533c571eeea0cb3678e1a57d3dc036fa8d0f49
ToppCell	Parenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MYLK SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	3653002c805c314043e2a7b0c9980dfe952dc53e
ToppCell	distal-Endothelial-Capillary_Intermediate_1-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYLK SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	43bc48413b100a06f8edd9acd812296788fcbf5b
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SETX SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	a1fa6bae5a688faf488d6925cd3fad725dfa916b
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYLK SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	3767abc75176779198505ebc6967d55ce322d9fe
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	NKTR SETX DOCK9 SON	5.82e-05	200	47	4	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	medial-2-Endothelial-Capillary_Intermediate_1\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYLK SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	a8adf5902540f6bb15b72efbb9c389b59d67e001
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYLK SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	e0a003d2a5fd6adfcb817c9bc5dceb9c79e7491b
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SETX SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCell	LPS_anti-TNF-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SETX SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	1d105eeda5a2c51f9a4654ffc79b7e2348ad593b
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SETX SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	58a7ece7dfdf6c46f2a50cbcb580574dec14c748
ToppCell	LPS_IL1RA_TNF-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SETX SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	d01cec331be3b03cef80e9536fc531285bcf00f6
ToppCell	LPS_anti-TNF-Endothelial-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SETX SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	60d2cbf41f37f1b11eddb4c9d9246c9c1fc5a5af
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	SETX SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	432384faeade8e609154fab3d96c955a8ec868dd
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	CDV3 BCLAF1 IGHG4 SON	5.82e-05	200	47	4	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SETX SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	medial-Endothelial-Capillary_Intermediate_1\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYLK SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	3ef7b7728615710c691aed8977e2582f19692cf9
ToppCell	distal-Endothelial-Capillary_Intermediate_1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYLK SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	4d6714d48738cdee7d535923f6dd2431e5304741
ToppCell	distal-2-Endothelial-Capillary_Intermediate_1\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYLK SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	7a99f28670ffb8ece7873d8a9bcd2a3936d0255d
ToppCell	medial-Endothelial-Capillary_Intermediate_1-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYLK SASH1 S1PR1 DOCK9	5.82e-05	200	47	4	707148e01e961097819a05437a842b7d3bf72b0a
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASP8AP2 NEB S1PR1	2.69e-04	119	47	3	c3f1223356e7f245a460ea5568a223e34e458dc1
ToppCell	Healthy-B_cell\|World / disease group, cell group and cell class	NEB S1PR1 DOCK9	4.89e-04	146	47	3	588359d3df6ad7090b7fa6c7f8d29cc1717e7f4f
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-NP-L5_NP_ALM_Trhr_Nefl\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LRRC63 PEAK1 CHN2	5.19e-04	149	47	3	558a441804dbcd5b5f39a3b1933b48976711ff15
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ATP7A BRCA1 S1PR1	5.93e-04	156	47	3	fbe23876f0899853cea3c5c4f3044a9cea064d5b
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NEB IGHG2 IGHG4	5.93e-04	156	47	3	d81e78bec5c8a3f3ec9e1447ebab2c5805b815eb
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MCM3 BRCA1 WDR76	5.93e-04	156	47	3	6f8622716bad4e505f241a2a4ef953bf3fc6dbfa
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	NKTR EML4 DOCK9	5.93e-04	156	47	3	1545169694f686d28648a68b552c2ae606599d66
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated\|Lung / Manually curated celltypes from each tissue	COPG2 NEB S1PR1	6.38e-04	160	47	3	9f7f24a52a24fb926df69c8e5aad64ee75a66ef1
ToppCell	Influenza_Severe-B_memory\|World / Disease group and Cell class	MUC16 IGHG2 IGHG4	6.61e-04	162	47	3	21eb96cd4fecd85dd6acbbc3760944fa1a7cff42
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-ABC_aged-B_memory\|bone_marrow / Manually curated celltypes from each tissue	MUC16 IGHG2 IGHG4	6.73e-04	163	47	3	30f5c93c4e170304d701b5231f0d545f404066f7
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|E18.5-samps / Age Group, Lineage, Cell class and subclass	CASS4 PEAK1 MYLK	6.85e-04	164	47	3	519ab4fe885dfe4c50846f346a062acc2cb44299
ToppCell	Influenza_Severe-B_memory\|Influenza_Severe / Disease group and Cell class	MUC16 IGHG2 IGHG4	6.98e-04	165	47	3	51172acaeb667b34b8b8c7878d67cfa0c4a2dffc
ToppCell	5'-Adult-Appendix-Hematopoietic-Plasma_cells-IgG_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NEB IGHG2 IGHG4	6.98e-04	165	47	3	79c6ad394266ff092029375883660028e944a3c8
ToppCell	normal_Lymph_Node-T/NK_cells-CD8+/CD4+_Mixed_Th\|T/NK_cells / Location, Cell class and cell subclass	CASS4 IGHG2 IGHG4	7.10e-04	166	47	3	d638d356592325cded4a6cb549041cf2f8d3e62c
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Proliferating_NK\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCM3 BRCA1 WDR76	7.10e-04	166	47	3	21ba5fd755c0fb31ada42a1b5d60bede0153323d
ToppCell	Bronchial_Biopsy-Immune-B_cells\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	IGHG2 IGHG4 APBB1IP	7.10e-04	166	47	3	22e94546b264c87cb55928d1591bf1b5ee2a76bd
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NKTR EML4 DOCK9	7.22e-04	167	47	3	83969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MCM3 NEB EML4	7.22e-04	167	47	3	859dfe0764cb69de27e79e1c1aa65f9d538f79ea
ToppCell	Int-URO-Lymphocyte-B-B_intermediate\|Int-URO / Disease, Lineage and Cell Type	NEB IGHG2 IGHG4	7.35e-04	168	47	3	5b3fb1fc8fea810c6d4e6feb42c24fb57e8066de
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	COPG2 ZNF280B DDX31	7.35e-04	168	47	3	2fb2d916eb5000a637240d38e47a9b4f61f9f83f
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|390C / Donor, Lineage, Cell class and subclass (all cells)	CASS4 ASXL2 EML4	7.48e-04	169	47	3	cfc9ff103d13a2d5eacc457e800f53fdd29f7738
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MCM3 BRCA1 WDR76	7.48e-04	169	47	3	121768fc51fc3441ec725346a1bbe29e21d05971
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CASS4 CASP8AP2 NEB	7.48e-04	169	47	3	16c52a0f6d96ecc1832922fce9b39691849f0d73
ToppCell	droplet-Lung-30m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BRCA1 WDR76 CHN2	7.48e-04	169	47	3	822e5b6c1e55e196e6d2a38bf183fd220c45703e
ToppCell	tumor_Lymph_Node_/_Brain-B_lymphocytes-Plasma_cells\|B_lymphocytes / Location, Cell class and cell subclass	MUC16 IGHG2 IGHG4	7.48e-04	169	47	3	150c08c7b1dc0f46173a7b8f6a3fc70d82906c0d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CASP8AP2 BRCA1 WDR76	7.48e-04	169	47	3	e7514956b2e4298222ec443f98b2f5289451786e
ToppCell	facs-Lung-EPCAM-18m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCM3 CHN2 PRPF40B	7.61e-04	170	47	3	12203d4410f38cc933d9f160b5fb76828df94119
ToppCell	facs-Lung-EPCAM-18m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCM3 CHN2 PRPF40B	7.61e-04	170	47	3	f9decb3bf3bf6d4996b0ac27af768236e116aac5
ToppCell	droplet-Lung-30m-Hematologic-myeloid-classical_monocyte_proliferating-\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MCM3 BRCA1 UBOX5	7.74e-04	171	47	3	1efce222989460bb59bd9fa955e7d9a60c73994c
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CASP8AP2 IGHG2 IGHG4	7.74e-04	171	47	3	a2938e56cb5749004317798dc7ac0f0c2d4d8ae0
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CASS4 MUC16 APBB1IP	7.87e-04	172	47	3	72fbfa890995e47048b47199c170cc7dcd7661f8
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CASS4 MUC16 APBB1IP	7.87e-04	172	47	3	2ca6f0d1181aabe0d0e3e8f2e193f08dbda42dea
ToppCell	367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	MCM3 BRCA1 WDR76	7.87e-04	172	47	3	8d20eda599abf1e9e3e3b90f314acddee6a465a4
ToppCell	COVID-19_Mild-PLT_2\|COVID-19_Mild / Disease Group and Platelet Clusters	MCM3 ASXL2 IGHG2	8.00e-04	173	47	3	d11705e56b6b21eec963ea224717f27680c781ed
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ZNF567 COPG2 WDR76	8.00e-04	173	47	3	20889aa85e36ad3bafdb91b91e43964493c949f9
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ZNF567 COPG2 WDR76	8.00e-04	173	47	3	46e601b7938b1dd0aa3df7aa056c4bd07b1620c1
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MCM3 BRCA1 WDR76	8.13e-04	174	47	3	c988471207ba06195bc3e41056435e8c31c20bbe
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MCM3 BRCA1 WDR76	8.13e-04	174	47	3	66555c610251ea04f968c258e312d720c18e7cde
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Regulatory_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASS4 NEB APBB1IP	8.27e-04	175	47	3	59a8481a3b4ed63b137baea25bc02f2078dc3ac7
ToppCell	droplet-Lung-21m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MCM3 BRCA1 WDR76	8.27e-04	175	47	3	6751ee4b312d7f87275f2c35e5878cfc3be3ebe3
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-regulatory_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASS4 NEB APBB1IP	8.27e-04	175	47	3	a2adaa09f37e3db5d819e56ed402fe04b72abeb2
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CASP8AP2 MCM3 CHN2	8.41e-04	176	47	3	d30241fb8119834d6e7b59efec3f92fc7a3d1247
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CASS4 ASXL2 EML4	8.41e-04	176	47	3	437cfc5e06416bb0fc76d1f9dc106f74e279e880
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MCM3 BRCA1 WDR76	8.41e-04	176	47	3	9e719e6323597ecfc758c957256872cd4ae24d4d
Computational	Genes upregulated in subsets of cells of a given type within various tumors	BDP1 NKTR SETX EML4	9.57e-06	49	30	4	GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CHROMATIN
Computational	Genes upregulated in subsets of cells of a given type within various tumors	NKTR PEAK1 SPEN	3.52e-04	50	30	3	GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_4
Disease	immunoglobulin G measurement	IGHG2 IGHG4	2.17e-06	2	44	2	EFO_0020465
Disease	double outlet right ventricle (implicated_via_orthology)	CFC1B CFC1	6.51e-06	3	44	2	DOID:6406 (implicated_via_orthology)
Disease	right atrial isomerism (implicated_via_orthology)	CFC1B CFC1	1.30e-05	4	44	2	DOID:0060856 (implicated_via_orthology)
Disease	dextro-looped transposition of the great arteries (implicated_via_orthology)	CFC1B CFC1	1.30e-05	4	44	2	DOID:0060770 (implicated_via_orthology)
Disease	Neointima Formation	ATP7A S1PR1	3.25e-05	6	44	2	C2936381
Disease	Neointima	ATP7A S1PR1	3.25e-05	6	44	2	C2936380
Disease	visceral heterotaxy (is_implicated_in)	CFC1B CFC1	1.42e-04	12	44	2	DOID:0050545 (is_implicated_in)
Disease	QRS duration, response to sulfonylurea	LRRC63 DOCK9	5.39e-04	23	44	2	EFO_0005055, EFO_0007922
Disease	visceral heterotaxy (implicated_via_orthology)	CFC1B CFC1	1.40e-03	37	44	2	DOID:0050545 (implicated_via_orthology)
Disease	esophagus squamous cell carcinoma (is_implicated_in)	BRCA1 SPEN	2.07e-03	45	44	2	DOID:3748 (is_implicated_in)
Disease	Salivary Gland Neoplasms	SPEN SON	2.25e-03	47	44	2	C0036095

Protein segments in the cluster

Peptide	Gene	Start	Entry
DTARKLQPKSHETVT	ZNF280B	81	Q86YH2
PVEEKRNSEKEVSSH	BDP1	1366	A6H8Y1
QRETESHQKSTPSTK	CASS4	616	Q9NQ75
SHQKSTPSTKQREDE	CASS4	621	Q9NQ75
QEAQRHAETSKDKKP	APBB1IP	481	Q7Z5R6
EEVTKVATQKHRQSP	CFC1B	36	P0CG36
TKKPTQDSCENTEAH	CASP8AP2	1861	Q9UKL3
PSLQSTAKHVESRKD	CDV3	196	Q9UKY7
EEVTKVATQKHRQSP	CFC1	36	P0CG37
NKCTLQHSDPEDRKT	CRISP2	76	P16562
QKPVTSAEQESEKNH	ASXL2	491	Q76L83
KRSLNSVVTSEPDKH	ATP7A	1471	Q04656
KEEIQETQTPTHSRK	NIFK	271	Q9BYG3
QAQHSATKVKDPTEE	RAB3GAP2	1226	Q9H2M9
EVTKDREKIHPSSNT	MUC16	8631	Q8WXI7
KTVSEEERKVHSPQQ	MYLK	936	Q15746
EQEHSNKAPRALTSK	GNL2	666	Q13823
NSTKSEKQTPREHSD	NCR3LG1	401	Q68D85
QDSEKKRSHSSPSQI	PEAK1	1026	Q9H792
KSTKHVREQIPDTAT	LRRC63	91	Q05C16
PKKHSVSTSDRNQEE	DDX31	181	Q9H8H2
HTPKTADSQETKESQ	MCM3	721	P25205
SNKPNEQTSKRHDSD	BRCA1	681	P38398
SRSKNEPRKTNVTHE	CHN2	171	P52757
RNSKSHVPEQKSRVD	CCDC82	11	Q8N4S0
PERNSEKSNSLDKHQ	DOCK9	1266	Q9BZ29
QKATEEHSTRQKSPE	BCLAF1	636	Q9NYF8
ERSDKVPENKNSHSL	COPG2	811	Q9UBF2
KHTLEQKTDTRENPQ	BTBD7	926	Q9P203
DHKPSNTKVDKTVER	IGHG2	86	P01859
DHKPSNTKVDKRVES	IGHG4	86	P01861
REKKEESHSNDQSPQ	EML4	126	Q9HC35
SRSKSDNSSHPQKDE	S1PR1	351	P21453
SQKRKIEQAEHVPDS	UBOX5	361	O94941
SERDVTKNSKNDSHP	NKTR	891	P30414
PKKTQRRHVSTAEET	SENP1	171	Q9P0U3
PEQHVSTVNSKEEKN	SETX	1046	Q7Z333
VTEVKEEPSSKREHQ	C12orf29	16	Q8N999
STKQETTHPEVKSHN	ZNF567	171	Q8N184
PERKSGQEKSHSVNT	SPEN	1141	Q96T58
ETHGDTRNDKIKPST	SRFBP1	321	Q8NEF9
VERKNPLHKSNSEDS	SASH1	126	O94885
KSHSQKEDQERPQVT	TEX13C	896	A0A0J9YWL9
TKKRRHKSNSPESET	PRPF40B	786	Q6NWY9
VHTESNKLQPKRTAD	WDR76	116	Q9H967
ETRNSPTQKTQKEIH	ZNF106	396	Q9H2Y7
RQPEESESKTKSHDD	SON	131	P18583
QPRESRKEKTESSHV	TTLL13	446	A6NNM8
VDTPEHLRTTKVNKQ	NEB	5456	P20929