Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix structural constituent

SLIT2 NID2 HSPG2 COL17A1 LAMB1 PCOLCE2 LTBP2 SSPOP

1.92e-07188668GO:0005201
GeneOntologyMolecularFunctioncalcium ion binding

SLIT2 NID2 HSPG2 FAT4 SCUBE1 SHH LTBP2 CUBN FLG2 LRP1B PCDH17 RYR1 CAPN11

8.55e-077496613GO:0005509
GeneOntologyMolecularFunctionglycosaminoglycan binding

SLIT2 COL17A1 PTPRS AZU1 SHH PCOLCE2 LTBP2

2.87e-05268667GO:0005539
GeneOntologyMolecularFunctionheparin binding

SLIT2 COL17A1 PTPRS AZU1 PCOLCE2 LTBP2

4.11e-05192666GO:0008201
GeneOntologyMolecularFunctionL-ornithine transmembrane transporter activity

SLC25A2 SLC25A15

1.07e-045662GO:0000064
GeneOntologyMolecularFunctionheparan sulfate proteoglycan binding

SLIT2 PTPRS AZU1

1.19e-0429663GO:0043395
GeneOntologyMolecularFunctioncollagen binding

NID2 HSPG2 ITGA10 PCOLCE2

1.50e-0481664GO:0005518
GeneOntologyMolecularFunctionlaminin-1 binding

SLIT2 SHH

2.97e-048662GO:0043237
GeneOntologyMolecularFunctionL-lysine transmembrane transporter activity

SLC25A2 SLC25A15

3.82e-049662GO:0015189
GeneOntologyMolecularFunctionproteoglycan binding

SLIT2 PTPRS AZU1

6.41e-0451663GO:0043394
GeneOntologyMolecularFunctionsulfur compound binding

SLIT2 COL17A1 PTPRS AZU1 PCOLCE2 LTBP2

6.87e-04323666GO:1901681
GeneOntologyMolecularFunctionL-arginine transmembrane transporter activity

SLC25A2 SLC25A15

8.20e-0413662GO:0061459
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

FLT4 INSRR EPHA1

1.30e-0365663GO:0004714
GeneOntologyMolecularFunctionextracellular matrix binding

SLIT2 SHH LTBP2

1.82e-0373663GO:0050840
GeneOntologyMolecularFunctionbasic amino acid transmembrane transporter activity

SLC25A2 SLC25A15

1.97e-0320662GO:0015174
GeneOntologyMolecularFunctionstructural molecule activity

SLIT2 NID2 HSPG2 COL17A1 LAMB1 PCOLCE2 LTBP2 FLG2 SSPOP

2.54e-03891669GO:0005198
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

FLT4 INSRR EPHA1

2.81e-0385663GO:0019199
GeneOntologyCellularComponentcollagen-containing extracellular matrix

SLIT2 NID2 HSPG2 PRTN3 COL17A1 SHH LAMB1 PCOLCE2 LTBP2 SSPOP

7.84e-065306810GO:0062023
GeneOntologyCellularComponentextracellular matrix

SLIT2 NID2 HSPG2 PRTN3 COL17A1 LRIG1 SHH LAMB1 PCOLCE2 LTBP2 SSPOP

8.06e-066566811GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

SLIT2 NID2 HSPG2 PRTN3 COL17A1 LRIG1 SHH LAMB1 PCOLCE2 LTBP2 SSPOP

8.30e-066586811GO:0030312
GeneOntologyCellularComponentbasement membrane

NID2 HSPG2 COL17A1 LAMB1

6.74e-04122684GO:0005604
DomainEGF_2

SLIT2 NID2 HSPG2 FAT4 SCUBE1 LAMB1 LRP5 LTBP2 CUBN LRP1B SSPOP EPHA1

1.87e-102656812PS01186
DomainGrowth_fac_rcpt_

NID2 HSPG2 FAT4 SCUBE1 INSRR LAMB1 LTBP2 CUBN LRP1B EPHA1

2.37e-101566810IPR009030
DomainEGF-like_Ca-bd_dom

SLIT2 NID2 HSPG2 FAT4 SCUBE1 LRP5 LTBP2 CUBN LRP1B

6.62e-10124689IPR001881
DomainEGF-like_CS

SLIT2 NID2 HSPG2 FAT4 SCUBE1 LAMB1 LRP5 LTBP2 CUBN LRP1B EPHA1

2.44e-092616811IPR013032
DomainEGF_CA

SLIT2 NID2 FAT4 SCUBE1 LRP5 LTBP2 CUBN LRP1B

2.66e-0999688PS01187
DomainEGF_3

SLIT2 NID2 HSPG2 FAT4 SCUBE1 LRP5 LTBP2 CUBN LRP1B SSPOP

1.26e-082356810PS50026
DomainEGF

SLIT2 NID2 HSPG2 FAT4 SCUBE1 LAMB1 LRP5 LTBP2 CUBN LRP1B

1.26e-082356810SM00181
DomainEGF_CA

SLIT2 NID2 HSPG2 FAT4 SCUBE1 LTBP2 CUBN LRP1B

1.40e-08122688SM00179
DomainEGF-like_dom

SLIT2 NID2 HSPG2 FAT4 SCUBE1 LAMB1 LRP5 LTBP2 CUBN LRP1B

2.19e-082496810IPR000742
DomainEGF_1

SLIT2 HSPG2 FAT4 SCUBE1 LAMB1 LRP5 LTBP2 CUBN LRP1B SSPOP

2.74e-082556810PS00022
DomainEGF_Ca-bd_CS

SLIT2 NID2 FAT4 SCUBE1 LTBP2 CUBN LRP1B

6.13e-0897687IPR018097
DomainASX_HYDROXYL

SLIT2 NID2 FAT4 SCUBE1 LTBP2 CUBN LRP1B

7.57e-08100687PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

SLIT2 NID2 FAT4 SCUBE1 LTBP2 CUBN LRP1B

1.13e-07106687IPR000152
DomainEGF

SLIT2 NID2 HSPG2 LRP5 LTBP2 CUBN LRP1B

3.71e-07126687PF00008
DomainEGF_CA

NID2 FAT4 SCUBE1 LTBP2 CUBN LRP1B

6.96e-0786686PF07645
DomainEGF_3

NID2 SCUBE1 CUBN

9.92e-0612683PF12947
DomainEGF_dom

NID2 SCUBE1 CUBN

9.92e-0612683IPR024731
DomainLDLR_class-A_CS

HSPG2 LRP5 LRP1B SSPOP

1.33e-0540684IPR023415
DomainLdl_recept_b

NID2 LRP5 LRP1B

1.63e-0514683PF00058
DomainLDLRB

NID2 LRP5 LRP1B

1.63e-0514683PS51120
DomainLY

NID2 LRP5 LRP1B

2.04e-0515683SM00135
DomainLDLR_classB_rpt

NID2 LRP5 LRP1B

2.04e-0515683IPR000033
DomainLdl_recept_a

HSPG2 LRP5 LRP1B SSPOP

2.14e-0545684PF00057
Domain-

HSPG2 LRP5 LRP1B SSPOP

2.34e-05466844.10.400.10
DomainLDLRA_1

HSPG2 LRP5 LRP1B SSPOP

2.77e-0548684PS01209
DomainCUB

SCUBE1 PCOLCE2 CUBN CSMD2

3.01e-0549684PF00431
DomainLDLRA_2

HSPG2 LRP5 LRP1B SSPOP

3.01e-0549684PS50068
DomainLDrepeatLR_classA_rpt

HSPG2 LRP5 LRP1B SSPOP

3.01e-0549684IPR002172
DomainLDLa

HSPG2 LRP5 LRP1B SSPOP

3.01e-0549684SM00192
DomainCUB

SCUBE1 PCOLCE2 CUBN CSMD2

3.26e-0550684SM00042
Domain-

SCUBE1 PCOLCE2 CUBN CSMD2

3.81e-05526842.60.120.290
DomainCUB

SCUBE1 PCOLCE2 CUBN CSMD2

4.11e-0553684PS01180
DomainCUB_dom

SCUBE1 PCOLCE2 CUBN CSMD2

5.49e-0557684IPR000859
DomaincEGF

NID2 SCUBE1 LRP1B

1.13e-0426683IPR026823
DomaincEGF

NID2 SCUBE1 LRP1B

1.13e-0426683PF12662
DomainNUT

NUTM2B NUTM2A

1.30e-045682IPR024310
DomainNUT_N

NUTM2B NUTM2A

1.30e-045682IPR024309
DomainNUT

NUTM2B NUTM2A

1.30e-045682PF12881
DomainLAM_G_DOMAIN

SLIT2 HSPG2 FAT4

3.55e-0438683PS50025
Domain-

NID2 LRP5 LRP1B

3.84e-04396832.120.10.30
DomainLaminin_G_2

SLIT2 HSPG2 FAT4

4.14e-0440683PF02210
DomainLamG

SLIT2 HSPG2 FAT4

5.49e-0444683SM00282
Domain6-blade_b-propeller_TolB-like

NID2 LRP5 LRP1B

6.26e-0446683IPR011042
DomainLaminin_G_1

SLIT2 HSPG2

7.03e-0411682PF00054
DomainConA-like_dom

SLIT2 HSPG2 FAT4 RNF39 RYR1

1.21e-03219685IPR013320
DomainLaminin_G

SLIT2 HSPG2 FAT4

1.23e-0358683IPR001791
DomainCTCK_1

SLIT2 SSPOP

1.92e-0318682PS01185
DomainEphrin_rec_like

SCUBE1 EPHA1

3.71e-0325682SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

SCUBE1 EPHA1

3.71e-0325682IPR011641
DomainCys_knot_C

SLIT2 SSPOP

3.71e-0325682IPR006207
DomainCTCK_2

SLIT2 SSPOP

3.71e-0325682PS01225
DomainTyrKc

FLT4 INSRR EPHA1

4.06e-0388683SM00219
DomainTyr_kinase_cat_dom

FLT4 INSRR EPHA1

4.06e-0388683IPR020635
DomainhEGF

SLIT2 FAT4

4.64e-0328682PF12661
DomainAden_trnslctor

SLC25A2 SLC25A15

4.64e-0328682IPR002113
DomainGalactose-bd-like

LAMB1 SSPOP EPHA1

4.88e-0394683IPR008979
Domain-

SLIT2 HSPG2 FAT4

5.03e-03956832.60.120.200
DomainIg_I-set

HSPG2 FLT4 LRIG1 PTPRS

5.09e-03190684IPR013098
DomainI-set

HSPG2 FLT4 LRIG1 PTPRS

5.09e-03190684PF07679
DomainEGF_LAM_2

HSPG2 LAMB1

5.32e-0330682PS50027
DomainEGF_LAM_1

HSPG2 LAMB1

5.32e-0330682PS01248
DomainPROTEIN_KINASE_TYR

FLT4 INSRR EPHA1

5.33e-0397683PS00109
DomainTyr_kinase_AS

FLT4 INSRR EPHA1

5.33e-0397683IPR008266
DomainLRRCT

SLIT2 LRIG1

6.04e-0332682PF01463
DomainEF-hand_8

RYR1 CAPN11

6.80e-0334682PF13833
DomainLaminin_EGF

HSPG2 LAMB1

7.19e-0335682PF00053
DomainEGF_Lam

HSPG2 LAMB1

7.19e-0335682SM00180
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

NID2 HSPG2 SCUBE1 COL17A1 PTPRS ITGA10 LAMB1 PCOLCE2 LTBP2 CAPN11

2.06e-073005510M610
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

NID2 SCUBE1 COL17A1 ITGA10 PCOLCE2 LTBP2 CAPN11

6.08e-05258557MM14572
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

HSPG2 SCUBE1 COL17A1 LAMB1 CAPN11

2.10e-04140555M587
PathwayREACTOME_LAMININ_INTERACTIONS

NID2 HSPG2 LAMB1

2.12e-0430553M27216
Pubmed

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.

FGF23 NID2 HSPG2 LAMB1 SSPOP

2.13e-076471522261194
Pubmed

Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development.

NID2 HSPG2 LAMB1

4.53e-07871312015298
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

SHH LRP5 LRP1B

1.33e-061171324639464
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

SLIT2 NID2 HSPG2 LAMB1 LTBP2 SSPOP

1.63e-0617571628071719
Pubmed

Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.

HSPG2 SHH LAMB1

2.92e-061471319783738
Pubmed

Basement membrane composition in the early mouse embryo day 7.

NID2 HSPG2 LAMB1

3.64e-061571315895400
Pubmed

Cloning and characterization of human ORNT2: a second mitochondrial ornithine transporter that can rescue a defective ORNT1 in patients with the hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a urea cycle disorder.

SLC25A2 SLC25A15

4.11e-06271212948741
Pubmed

Characterization of two azurphil granule proteases with active-site homology to neutrophil elastase.

PRTN3 AZU1

4.11e-0627122404977
Pubmed

Substrate specificity of the two mitochondrial ornithine carriers can be swapped by single mutation in substrate binding site.

SLC25A2 SLC25A15

4.11e-06271222262851
Pubmed

The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms.

SLC25A2 SLC25A15

4.11e-06271212807890
Pubmed

Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling.

LRIG1 SHH LAMB1

4.48e-061671335132078
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

HSPG2 FAT4 PTPRS FHOD1 LAMB1 LRP5 PCOLCE2 TTC13 LTBP2 LRP1B GALNT4 DCAF12

5.31e-061201711235696571
Pubmed

Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs.

NID2 HSPG2 SHH

6.51e-061871312571105
Pubmed

The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.

NUTM2B NUTM2A

1.23e-05371222456610
Pubmed

Functional dissociation between proforms and mature forms of proteinase 3, azurocidin, and granzyme B in regulation of granulopoiesis.

PRTN3 AZU1

1.23e-05371212135665
Pubmed

An mTurq2-Col4a1 mouse model allows for live visualization of mammalian basement membrane development.

HSPG2 LAMB1

1.23e-05371238051393
Pubmed

Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.

PRTN3 AZU1

1.23e-0537121518849
Pubmed

Expression of GLI1 correlates with expression of lymphangiogenesis proteins, vascular endothelial growth factor C and vascular endothelial growth factor receptor 3, in colorectal cancer.

FLT4 SHH

2.46e-05471223336661
Pubmed

The transcription factor NKX2-3 mediates p21 expression and ectodysplasin-A signaling in the enamel knot for cusp formation in tooth development.

HSPG2 NKX2-3

2.46e-05471230089653
Pubmed

Downregulation of hedgehog ligands in human simple steatosis may protect against nonalcoholic steatohepatitis: Is TAZ a crucial regulator?

SHH WWTR1

2.46e-05471231087761
Pubmed

Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function.

HSPG2 SHH

2.46e-05471226056142
Pubmed

Hair follicles modulate skin barrier function.

LRIG1 SHH

2.46e-05471238941190
Pubmed

Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis.

SLIT2 EPHA1

2.46e-05471221135133
Pubmed

Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.

NID2 HSPG2 LAMB1

2.87e-052971322613833
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

HSPG2 FAT4 EIF4ENIF1 NUTM2B LAMB1 USP54 SSPOP PCDH17

3.37e-0560871816713569
Pubmed

Scube3 is expressed in multiple tissues during development but is dispensable for embryonic survival in the mouse.

SCUBE1 SHH

4.09e-05571223383134
Pubmed

CDK7 regulates organ size and tumor growth by safeguarding the Hippo pathway effector Yki/Yap/Taz in the nucleus.

WWTR1 DCAF12

4.09e-05571231857346
Pubmed

Binding of mouse nidogen-2 to basement membrane components and cells and its expression in embryonic and adult tissues suggest complementary functions of the two nidogens.

NID2 HSPG2

4.09e-05571212243745
Pubmed

Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan.

NID2 HSPG2

4.09e-05571211493006
Pubmed

Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly.

FAT4 WWTR1

4.09e-05571230862798
Pubmed

Lung epithelial branching program antagonizes alveolar differentiation.

NID2 HSPG2 SHH

4.26e-053371324058167
Pubmed

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.

NID2 HSPG2 LAMB1 LTBP2

4.79e-059771427559042
Pubmed

Proteomics characterization of extracellular space components in the human aorta.

NID2 HSPG2 PRTN3 LTBP2

5.61e-0510171420551380
Pubmed

The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin.

NID2 HSPG2

6.13e-05671211956183
Pubmed

Nidogen-2: a new basement membrane protein with diverse binding properties.

NID2 HSPG2

6.13e-0567129733643
Pubmed

Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins.

NID2 HSPG2

6.13e-05671210544250
Pubmed

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.

FLT4 INSRR EPHA1

7.63e-054071330898150
Pubmed

The murine homeobox genes Nkx2.3 and Nkx2.6 are located on chromosomes 19 and 14, respectively.

COL17A1 NKX2-3

8.57e-0577128001981
Pubmed

Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages.

LRIG1 SHH

8.57e-05771226837596
Pubmed

YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis.

FLT4 WWTR1

8.57e-05771230582452
Pubmed

Disruption of Scube2 Impairs Endochondral Bone Formation.

SCUBE1 SHH

8.57e-05771225639508
Pubmed

NKX2 gene expression in neuroectoderm but not in mesendodermally derived structures depends on sonic hedgehog in mouse embryos.

NKX2-3 SHH

8.57e-05771210603087
Pubmed

The mesenchymal alpha11beta1 integrin attenuates PDGF-BB-stimulated chemotaxis of embryonic fibroblasts on collagens.

ITGA10 LAMB1

8.57e-05771215183724
Pubmed

Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription.

LRIG1 WWTR1

1.14e-04871232259481
Pubmed

The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor.

NID2 HSPG2

1.14e-04871211847210
Pubmed

Antibiotic proteins of human polymorphonuclear leukocytes.

PRTN3 AZU1

1.14e-0487122501794
Pubmed

A molecular program for contralateral trajectory: Rig-1 control by LIM homeodomain transcription factors.

SLIT2 SHH

1.14e-04871218701067
Pubmed

Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.

PPP2R1B PKP2 WWTR1 DCAF12

1.32e-0412671424319055
Pubmed

Protein profile of exosomes from trabecular meshwork cells.

HSPG2 LAMB1 LTBP2

1.40e-044971321362503
Pubmed

Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches.

LRIG1 SHH

1.47e-04971225842978
Pubmed

Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners.

NID2 HSPG2

1.47e-04971222952693
Pubmed

Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo.

SHH WWTR1

1.47e-04971233947861
Pubmed

Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese.

HSPG2 COL17A1

1.47e-04971215081423
Pubmed

A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning.

NID2 SHH

1.47e-04971214530295
Pubmed

Identification of the ligands of protein interaction domains through a functional approach.

CUBN RGS12

1.47e-04971217124247
Pubmed

An LDL-receptor-related protein mediates Wnt signalling in mice.

SHH LRP5

1.47e-04971211029008
Pubmed

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis.

SHH LAMB1 LRP5

1.49e-045071324191021
Pubmed

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.

NID2 HSPG2 LAMB1

1.49e-045071323658023
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

SLIT2 NID2 HSPG2 LAMB1 LTBP2

1.57e-0424871524006456
Pubmed

Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.

TNIP2 FHOD1 LAMB1 PCDH17

1.63e-0413371415604093
Pubmed

The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.

KLHDC2 DCAF12

1.83e-041071229779948
Pubmed

Generation of a conditionally null allele of the laminin alpha1 gene.

HSPG2 LAMB1

1.83e-041071216100707
Pubmed

Integrin alpha6beta1-laminin interactions regulate early myotome formation in the mouse embryo.

HSPG2 LAMB1

1.83e-041071216554364
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

HSPG2 FLT4 PTPRS SHH LAMB1

1.85e-0425771516335952
Pubmed

Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.

SLIT2 LRP5 LTBP2 RGS12

2.09e-0414271419851296
Pubmed

Association of genetic variants with hemorrhagic stroke in Japanese individuals.

SLIT2 LRP5 LTBP2 RGS12

2.15e-0414371420198315
Pubmed

Extracellular matrix protein composition dynamically changes during murine forelimb development.

NID2 HSPG2

2.23e-041171238303699
Pubmed

Loss of nidogen-1 and -2 results in syndactyly and changes in limb development.

NID2 HSPG2

2.23e-041171217023412
Pubmed

Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth.

FAT4 PKP2

2.23e-041171228239148
Pubmed

Dchs1-Fat4 regulation of osteogenic differentiation in mouse.

FAT4 WWTR1

2.23e-041171231358536
Pubmed

Absence of Nkx2-3 homeodomain transcription factor induces the formation of LYVE-1-positive endothelial cysts without lymphatic commitment in the spleen.

FLT4 NKX2-3

2.23e-041171221705651
Pubmed

Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells.

LRIG1 SHH

2.23e-041171223487314
Pubmed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

NID2 HSPG2 LAMB1 LTBP2

2.33e-0414671427068509
Pubmed

Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.

BCL9L CD82 KLHDC2 PTPRS CUBN EPHA1

2.57e-044327167671812
Pubmed

Roundabout receptors are critical for foregut separation from the body wall.

SLIT2 SHH

2.68e-041271223328398
Pubmed

Shox2 is required for the proper development of the facial motor nucleus and the establishment of the facial nerves.

SLIT2 SHH

2.68e-041271226156498
Pubmed

Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice.

HSPG2 SHH

2.68e-041271222072575
Pubmed

Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections.

SLIT2 SHH

2.68e-041271211830575
Pubmed

Kindlin-2 Is Essential for Preserving Integrity of the Developing Heart and Preventing Ventricular Rupture.

HSPG2 WWTR1

2.68e-041271230883226
Pubmed

Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development.

SHH LRP5

2.68e-041271227864382
Pubmed

Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice.

NID2 HSPG2

2.68e-041271216024816
Pubmed

The DNA sequence and biology of human chromosome 19.

PRTN3 PTPRS AZU1 ZNF861P RYR1

2.94e-0428471515057824
Pubmed

Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.

PLEKHG4B CSMD2 DCAF12

2.97e-046371311572484
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

BCL9L EIF4ENIF1 PKP2 CEP192 USP54 LRCH3

3.05e-0444671624255178
Pubmed

Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane.

HSPG2 LAMB1

3.16e-041371212682087
Pubmed

Basement membranes in skin are differently affected by lack of nidogen 1 and 2.

NID2 HSPG2

3.16e-041371218356808
Pubmed

VE-Cadherin Is Required for Lymphatic Valve Formation and Maintenance.

FLT4 WWTR1

3.16e-041371231461654
Pubmed

Ontogenesis of the tear drainage system requires Prickle1-driven polarized basement membrane deposition.

HSPG2 LAMB1

3.16e-041371233144400
Pubmed

YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling.

FLT4 WWTR1

3.16e-041371233060128
Pubmed

Developmental guidance of the retroflex tract at its bending point involves Robo1-Slit2-mediated floor plate repulsion.

SLIT2 SHH

3.16e-041371225366972
Pubmed

Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin Signaling.

FLT4 LRP5

3.16e-041371230332639
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

NID2 HSPG2 PPP2R1B FAT4 PRTN3 PTPRS AZU1 LTBP2 CUBN

3.22e-04107071923533145
Pubmed

MED12 regulates a transcriptional network of calcium-handling genes in the heart.

SLC8A2 RYR1

3.68e-041471228724790
Pubmed

Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression.

HSPG2 LAMB1

3.68e-041471218559345
Pubmed

Membrane-type MMPs are indispensable for placental labyrinth formation and development.

NID2 HSPG2

3.68e-041471220858856
Pubmed

Dystroglycan organizes axon guidance cue localization and axonal pathfinding.

SLIT2 HSPG2

3.68e-041471223217742
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

HSPG2 LAMB1 PCOLCE2 LTBP2

3.88e-0416771422159717
Pubmed

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.

NID2 CD82 TNIP2 PCOLCE2 USP54

3.89e-0430271530561431
Pubmed

A simple method for 3D analysis of immunolabeled axonal tracts in a transparent nervous system.

SLIT2 SHH

4.24e-041571225456121
Pubmed

Phenotypic analysis of mice completely lacking netrin 1.

SLIT2 SHH

4.24e-041571226395479
InteractionFBXO2 interactions

SLIT2 NID2 HSPG2 LRIG1 PTPRS AZU1 LAMB1 TTC13 LRP1B EPHA1

1.30e-064116910int:FBXO2
InteractionDEFA1 interactions

SLIT2 NID2 LRIG1 LAMB1 TTC13

2.38e-05100695int:DEFA1
InteractionTXNDC2 interactions

TRMT2A SLC25A15 SSRP1

2.52e-0517693int:TXNDC2
GeneFamilyLow density lipoprotein receptors

LRP5 LRP1B

3.67e-0413402634
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

HSPG2 FLT4 LRIG1 PTPRS

4.31e-04161404593
GeneFamilyReceptor Tyrosine Kinases|CD molecules

FLT4 INSRR

3.53e-0340402321
GeneFamilyFibronectin type III domain containing

PTPRS INSRR EPHA1

5.29e-03160403555
CoexpressionNABA_CORE_MATRISOME

SLIT2 NID2 HSPG2 COL17A1 LAMB1 PCOLCE2 LTBP2 SSPOP

6.94e-07270718MM17057
CoexpressionNABA_CORE_MATRISOME

SLIT2 NID2 HSPG2 COL17A1 LAMB1 PCOLCE2 LTBP2 SSPOP

7.97e-07275718M5884
CoexpressionHEVNER_TELENCEPHALON_VASCULAR_ENDOTHELIUM_AND_MENINGEAL_CELLS

NID2 HSPG2 LAMB1

8.47e-0615713MM402
CoexpressionNABA_ECM_GLYCOPROTEINS

SLIT2 NID2 LAMB1 PCOLCE2 LTBP2 SSPOP

1.34e-05191716MM17059
CoexpressionNABA_MATRISOME

SLIT2 FGF23 NID2 HSPG2 SCUBE1 COL17A1 SHH LAMB1 PCOLCE2 LTBP2 FLG2 SSPOP

1.55e-0510087112MM17056
CoexpressionNABA_ECM_GLYCOPROTEINS

SLIT2 NID2 LAMB1 PCOLCE2 LTBP2 SSPOP

1.55e-05196716M3008
CoexpressionNABA_MATRISOME

SLIT2 FGF23 NID2 HSPG2 SCUBE1 COL17A1 SHH LAMB1 PCOLCE2 LTBP2 FLG2 SSPOP

1.84e-0510267112M5889
CoexpressionONDER_CDH1_TARGETS_2_UP

NID2 FAT4 LRIG1 ITGA10 PCOLCE2 LTBP2

7.04e-05257716M13867
CoexpressionHE_LIM_SUN_FETAL_LUNG_C7_MID_SCHWANN_CELL

SLIT2 NID2 HSPG2 CD82 LRIG1 LAMB1

8.87e-05268716M45796
CoexpressionNABA_MATRISOME_PRIMARY_METASTATIC_LUNG_TUMOR

NID2 HSPG2 LTBP2

1.17e-0435713MM17054
ToppCell343B-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SLIT2 CD82 PTPRS FHOD1 LAMB1 LTBP2 EPHA1

2.82e-08199707212e89d097753790061310373a1fafba773488b6
ToppCell343B-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SLIT2 CD82 PTPRS FHOD1 LAMB1 LTBP2 EPHA1

2.82e-0819970714b676aa289c0578a37be32cec3ea285c79d97cc
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SCUBE1 PRTN3 COL17A1 AZU1 PCOLCE2 CSMD2

4.84e-0812670669b2525b92d1c7c35b21cc701f5fa52a9c1b94bb
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SCUBE1 PRTN3 COL17A1 AZU1 PCOLCE2 CSMD2

4.84e-081267066cb89754010d64875e115da6c5805efac7a4a82d
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-proliferating_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FGF23 HSPG2 FLT4 LAMB1 WWTR1 PCDH17

4.27e-07182706997d37ca2af661c92a56add888762724dfccc890
ToppCell10x5'v1-week_12-13-Endothelial-stroma-tip_EC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FGF23 HSPG2 FLT4 LAMB1 WWTR1 PCDH17

5.66e-07191706cf1a67b7c0d5c0dc5d4d59faf9d9b1a3a1fb00e0
ToppCelldroplet-Pancreas-PANCREAS-30m-Endothelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 FAT4 FLT4 NKX2-3 WWTR1 PCDH17

5.84e-07192706f4cd65e6c5b17bcabf45fe5b687246c72e7975f7
ToppCelldroplet-Pancreas-PANCREAS-30m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 FAT4 FLT4 NKX2-3 WWTR1 PCDH17

5.84e-07192706bcd8876235be503186f119653b39476488c0fa15
ToppCell10x5'v1-week_14-16-Endothelial-stroma-proliferating_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FLT4 LAMB1 WWTR1 RNF39 PCDH17

6.20e-071947068a4be91414a2e69dd410aa75791f16008204c9a1
ToppCell10x5'v1-week_17-19-Endothelial|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FAT4 FLT4 LAMB1 WWTR1 PCDH17

6.20e-07194706e141beafc9252e5d8c949252bfab53e127c881dc
ToppCell10x5'v1-week_17-19-Endothelial-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FAT4 FLT4 LAMB1 WWTR1 PCDH17

6.20e-07194706953578102ffc7b612ee8fce45e414750800fef5d
ToppCell10x5'v1-week_17-19-Endothelial-stroma-sinusoidal_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FLT4 LAMB1 LRP5 WWTR1 PCDH17

6.39e-0719570622a481927147ec4ae9d59e6af7c87df0e9cb51e4
ToppCell10x3'2.3-week_17-19-Endothelial-stroma-sinusoidal_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FGF23 HSPG2 FLT4 LAMB1 WWTR1 PCDH17

6.78e-071977064e58bbf3ecb30b4c8199adcc04d2eb134d90de56
ToppCellmetastatic_Brain-Endothelial_cells|metastatic_Brain / Location, Cell class and cell subclass

HSPG2 FLT4 ITGA10 WWTR1 CUBN PCDH17

6.98e-0719870697ef7946ef11ac93318c1dd46b548dc01e5a6aba
ToppCellmetastatic_Brain-Endothelial_cells-Tumor_ECs|metastatic_Brain / Location, Cell class and cell subclass

HSPG2 FLT4 ITGA10 WWTR1 CUBN PCDH17

6.98e-071987065e274f29cc796dae7d64d6035e904816c25f9914
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SCUBE1 CD82 LRIG1 ITGA10 LTBP2 LRP1B

7.19e-07199706a207b4891881149d4c50721310690fd794157723
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 NID2 FAT4 INSRR LAMB1 LTBP2

7.19e-0719970621335475bbfbad8a6943b8076a6c1c67f3eec5d3
ToppCell10x5'v1-week_14-16-Endothelial-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FLT4 LAMB1 LRP5 WWTR1 PCDH17

7.41e-072007062488aa12970a43a5af352e2c36c73884d73a1cc5
ToppCellproximal-mesenchymal-Fibromyocyte-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FGF23 FAT4 SCUBE1 CD82 ITGA10 LTBP2

7.41e-0720070637d9f46f727a31e8e94e348e4ddd71a2125ba01a
ToppCellproximal-3-mesenchymal-Fibromyocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FGF23 FAT4 SCUBE1 CD82 ITGA10 LTBP2

7.41e-07200706ed6fbe61a04d29b105054f7058abe7469314b304
ToppCell10x5'v1-week_14-16-Endothelial-stroma-sinusoidal_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FLT4 LAMB1 LRP5 WWTR1 PCDH17

7.41e-07200706ae429f2de652cc1976e63644781197e9ce0e70c8
ToppCell10x5'v1-week_14-16-Endothelial|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FLT4 LAMB1 LRP5 WWTR1 PCDH17

7.41e-07200706e786544cf6f891550c4be55ebb4928c92297b504
ToppCellproximal-mesenchymal-Fibromyocyte|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FGF23 FAT4 SCUBE1 CD82 ITGA10 LTBP2

7.41e-0720070649658e1b530de0dad16d45a1112bdf5329bb800d
ToppCellAdult-Mesenchymal-myofibroblast_cell-D175|Adult / Lineage, Cell type, age group and donor

SLIT2 NID2 LTBP2 CSMD2 KIAA1614

5.53e-06161705048b7dc00746987a24bf870d4d278c4183eb04a2
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor_pre-Lymphocytic-T|bone_marrow / Manually curated celltypes from each tissue

PRTN3 COL17A1 AZU1 RNF39 CAPN11

6.42e-0616670520f248d95c86eb52a1efe9abe73123fbe4206caf
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

SLIT2 PTPRS INSRR LAMB1 PCOLCE2

7.00e-061697056373562ab3b1765060212a6a53d6543e7e942e80
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FGF23 HSPG2 ITGA10 PCDH17 CAPN11

8.76e-06177705fdf2af00fc971f0cd3915e1416e4a256458d6ea8
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FGF23 HSPG2 ITGA10 PCDH17 CAPN11

8.76e-0617770512f8627124acbf436e75681ff1ce429ff5e3f256
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 FAT4 FLT4 COL17A1 CCNJ

8.76e-061777058ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

LRIG1 SHH WWTR1 USP54 PCDH17

9.00e-06178705f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCellAdult-Epithelial-club_cell-D122|Adult / Lineage, Cell type, age group and donor

PLEKHG4B LRIG1 WWTR1 RNF39 LRP1B

9.00e-0617870535a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAT4 SCUBE1 ITGA10 LAMB1 LTBP2

9.51e-0618070501f2e5d96016823482f89ba503d007d4bd88eeac
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 FAT4 FLT4 COL17A1 CCNJ

9.76e-061817054df7972f88117108698efd06b124b232f8588981
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 FAT4 FLT4 COL17A1 CCNJ

9.76e-06181705cbb530566893281289026bfd93adf721decd4ca3
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-Alveolar_Mac|Myeloid_cells / Location, Cell class and cell subclass

AZU1 PKP2 PCOLCE2 RGS12 CAPN11

1.00e-05182705a035d45fd512bee8dac38eb387dbf39f5a8a1fed
ToppCellnormal_Lung-Endothelial_cells-Tumor_ECs|normal_Lung / Location, Cell class and cell subclass

HSPG2 FLT4 NKX2-3 LAMB1 PCDH17

1.06e-051847057ee98acda030366ac6cf3890a6d93fd0426712ed
ToppCellP15-Mesenchymal-mesenchymal_fibroblast|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SLIT2 CD82 LAMB1 PCOLCE2 EPHA1

1.09e-0518570546460e74cc613df9043f5404e7342aa13cc34873
ToppCell10x5'v1-week_12-13-Endothelial-stroma-sinusoidal_EC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FLT4 LAMB1 WWTR1 PCDH17

1.11e-05186705e8ead5634686ebaa6a230eea69795d923ce9939d
ToppCell356C-Endothelial_cells-Endothelial-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

HSPG2 WWTR1 CUBN PCDH17 CAPN11

1.11e-051867052e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell356C-Endothelial_cells-Endothelial-E|356C / Donor, Lineage, Cell class and subclass (all cells)

HSPG2 WWTR1 CUBN PCDH17 CAPN11

1.11e-05186705c3449e54454009973818fc1101933c6f0168258c
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SLIT2 CD82 LAMB1 PCOLCE2 EPHA1

1.11e-0518670588e6246172d816806a498a5c1f38e699f2f5d7c2
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D175|Adult / Lineage, Cell type, age group and donor

SLIT2 PTPRS FHOD1 LAMB1 LTBP2

1.14e-05187705e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCelldroplet-Pancreas-PANCREAS-30m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 FLT4 NKX2-3 LAMB1 PCDH17

1.23e-051907059d5242759546be0089981ef1877e4ed5f81face5
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SCUBE1 LRIG1 ITGA10 LTBP2 LRP1B

1.23e-05190705938d1f66094b1c94606e0d40213a39e5112f3322
ToppCell10x5'v1-week_17-19-Endothelial-stroma-proliferating_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FAT4 FLT4 LAMB1 PCDH17

1.27e-05191705dc9e5eb6aa31b8d79aeec33e59b9138dfb469a3b
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SLIT2 FAT4 PTPRS LAMB1 LTBP2

1.27e-051917056688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCelldroplet-Pancreas-Exocrine-18m-Endothelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NID2 HSPG2 FLT4 LAMB1 WWTR1

1.30e-05192705a42aed9e563f5f4af029b8804c104f11ad227a8f
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

SLIT2 NID2 LAMB1 WWTR1 LTBP2

1.30e-0519270560b1312e84f6d6448365a952469c506c00b5fe93
ToppCelldroplet-Pancreas-Endocrine-18m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NID2 HSPG2 FLT4 NKX2-3 PCDH17

1.33e-051937055d42979d811ee13a07dee08a3743a90776017cb4
ToppCelldroplet-Pancreas-Endocrine-18m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NID2 HSPG2 FLT4 NKX2-3 PCDH17

1.33e-0519370595e64b9580d30c28702639a043a8b72ce1cadeb6
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 FAT4 FLT4 WWTR1 PCDH17

1.33e-05193705826b8dd801298b3e0cd76232feae5a14026b8806
ToppCelldroplet-Pancreas-Endocrine-18m-Endothelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NID2 HSPG2 FLT4 NKX2-3 PCDH17

1.33e-0519370597c0730aad9135ac681250b3871cc094a28f80a7
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

PLEKHG4B LRIG1 WWTR1 USP54 RNF39

1.33e-051937052bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 FAT4 FLT4 WWTR1 PCDH17

1.33e-0519370587d3a577d37fb0cb4b6313c596310de452bc3872
ToppCellLV-01._Fibroblast_I|LV / Chamber and Cluster_Paper

SLIT2 PTPRS LAMB1 PCOLCE2 LTBP2

1.33e-05193705dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCellCOVID-19-kidney-PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

HSPG2 SCUBE1 FLT4 WWTR1 PCDH17

1.40e-05195705a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 FAT4 LAMB1 LTBP2 KIAA1614

1.40e-05195705f5e91ce20a7ce528dc4c1a968c7bf096bf45c528
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SLIT2 CD82 FHOD1 LAMB1 LTBP2

1.43e-051967056730743cf088c419ccc2d28765769fc09d3ba6a7
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SLIT2 CD82 FHOD1 LAMB1 LTBP2

1.43e-0519670521dab89f3699037138a9c7a0e4dc98739a9fad9c
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-sinusoidal_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FLT4 LAMB1 WWTR1 PCDH17

1.47e-05197705f1080d93acf1a4756d2f2c8cabd1fb50bc7bcd09
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 FAT4 FLT4 WWTR1 PCDH17

1.47e-05197705c10dd1aaec01fb662eac83dfde90e3e426665d65
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLIT2 FAT4 PTPRS LAMB1 LTBP2

1.47e-0519770594a9603cbd3516fbcce871909693b88f20d41713
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal-mesenchymal_stem_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NID2 HSPG2 PTPRS LAMB1 LRP1B

1.47e-051977053bb92dd8a94e2be3b7fe51c9a21b241215477ac7
ToppCell10x3'2.3-week_17-19-Endothelial-stroma-tip_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

NID2 HSPG2 LAMB1 WWTR1 PCDH17

1.47e-05197705b212ff28ca2d1fea4140f186ab90941bdca21249
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 FAT4 INSRR LAMB1 LTBP2

1.47e-0519770544673c38384453207871d3fd8e8ba9093cc06bc5
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NID2 HSPG2 PTPRS LAMB1 LRP1B

1.47e-0519770517344464fdcc5ba0c03959696b97c195f11e644c
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 FAT4 FLT4 WWTR1 PCDH17

1.47e-051977052844dbcd0a673ed81c99920aa45858651a00736d
ToppCellCOVID-19-Fibroblasts|COVID-19 / group, cell type (main and fine annotations)

SLIT2 PTPRS LAMB1 LTBP2 CSMD2

1.47e-05197705fb847f2277609c31fffcdf49517243ce0684facf
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NID2 HSPG2 PTPRS LAMB1 LRP1B

1.47e-051977055b8d0d7116b20d8e27541e88ec80c9f1f477e384
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

SLIT2 FAT4 CD82 LAMB1 LTBP2

1.47e-05197705f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SCUBE1 CD82 LRIG1 ITGA10 LTBP2

1.51e-05198705637f11e292b90d86cdc0d0d828eb26f38289c25b
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SCUBE1 CD82 LRIG1 ITGA10 LTBP2

1.51e-051987052d0c14f8cabab99bc6d7c27685437c78841c7245
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PLEKHG4B NID2 HSPG2 LAMB1 LTBP2

1.51e-051987058b9e8eaeffda40912a0163fdf39b93bc5e64751c
ToppCellParenchymal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 FAT4 SCUBE1 LAMB1 LTBP2

1.51e-05198705300d7cc56207d77168390fa1ffcbcf76767b1b80
ToppCell10x3'2.3-week_17-19-Endothelial|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FLT4 LAMB1 WWTR1 PCDH17

1.51e-051987052630a7a6e56febe5c0b0bde70dd7292fa1650c47
ToppCell10x5'v1-week_12-13-Endothelial-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FLT4 LAMB1 WWTR1 PCDH17

1.51e-05198705122215d9288533ad03562cf777e846504863df9a
ToppCell10x5'v1-week_12-13-Endothelial|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FLT4 LAMB1 WWTR1 PCDH17

1.51e-05198705307dd09e6bc820a148f3000f18dae7aedba4be0b
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PLEKHG4B NID2 HSPG2 LAMB1 LTBP2

1.51e-05198705eb78b2ae6a787dbc75947e8dd5a03693285bc8be
ToppCellFibroblasts-HLA-DRA_high_Fibroblasts|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

SLIT2 NID2 HSPG2 LAMB1 WWTR1

1.51e-05198705e8c0fbf306fae13e97caa294d7c99a564bd97130
ToppCell10x3'2.3-week_17-19-Endothelial-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FLT4 LAMB1 WWTR1 PCDH17

1.51e-051987051e83bec16dcd60460422625f89952ff506d6be51
ToppCell10x3'2.3-week_14-16-Endothelial|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FLT4 LAMB1 WWTR1 PCDH17

1.54e-0519970541f046646fff65b7e51b63d3204f76ef32054781
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NID2 ITGA10 PKP2 LTBP2 FLG2

1.54e-05199705dfc5c7a4a093baa7158dd8d4d29a870d9c469a3f
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-tip_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FLT4 LAMB1 WWTR1 PCDH17

1.54e-051997051c69395c9305b6ecb0a826d46c8e8ec95795ad6d
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NID2 HSPG2 FLT4 SLC25A15 ITGA10

1.54e-051997051295f34a350bf48987e2fad411aaac3630efd3f1
ToppCell343B-Fibroblasts-Fibroblast-G|343B / Donor, Lineage, Cell class and subclass (all cells)

SLIT2 CD82 PTPRS LAMB1 LTBP2

1.54e-05199705f4b6c095cbe7a38b310adc49be4069e4d56e6a66
ToppCell343B-Fibroblasts-Fibroblast-G-|343B / Donor, Lineage, Cell class and subclass (all cells)

SLIT2 CD82 PTPRS LAMB1 LTBP2

1.54e-051997059c6d1c328bfbb6547f4c7bb2a784576a56bd72af
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NID2 HSPG2 FLT4 WWTR1 CUBN

1.54e-0519970563c01e8961f48ed1bed4ab619cacf318cd6de7b9
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NID2 ITGA10 PKP2 LTBP2 FLG2

1.54e-05199705c1760581c34b81d1d92c67500a1c8944e9cc6dad
ToppCell10x3'2.3-week_14-16-Endothelial-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FLT4 LAMB1 WWTR1 PCDH17

1.54e-05199705ef7f7f7c861827574b120f48cf4052c563929081
ToppCell10x5'v1-week_14-16-Endothelial-stroma-tip_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 FLT4 LAMB1 WWTR1 PCDH17

1.58e-0520070577ac1aa73c16a4f595ff01c6b4e171e0b8fed1e6
ToppCellParenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

SLIT2 FAT4 PTPRS LAMB1 LTBP2

1.58e-05200705aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

SLIT2 FAT4 PTPRS LAMB1 LTBP2

1.58e-05200705a510deaada669e690329183e18df02870bd204b3
ToppCellBronchial-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 FAT4 PTPRS LAMB1 LTBP2

1.58e-05200705cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 NID2 FAT4 LAMB1 LTBP2

1.58e-052007053dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SLIT2 FAT4 PTPRS LAMB1 LTBP2

1.58e-05200705dd4228cbed8a4395166a6332e08d44d88bebe3b9
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PRTN3 COL17A1 AZU1 PCOLCE2

3.04e-05113704b795a0c65114b3c0758fe3720e8a80247f900971
ToppCellCOVID-19_Mild-Myeloid_G-immature_Neutrophil|COVID-19_Mild / Disease group, lineage and cell class

PRTN3 COL17A1 AZU1 PCOLCE2

3.04e-05113704fc3417c379f871a4aec3edef953baaa00755c472
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

PRTN3 COL17A1 AZU1 PCOLCE2

3.15e-05114704613714fd15ad6d553e63d8538ad53bc1ded6bd6c
ToppCellCOVID_non-vent-Myeloid-Monocytic-Developing_Neutrophil|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

PRTN3 COL17A1 AZU1 PCOLCE2

5.42e-051317045b29f0dc449b9fff5e8bf6365080168f31b7e268
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-oligodendrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HDAC11 CUBN LRP1B SSPOP

9.17e-05150704afd651c654e715414eff64cf3a37378d057a56a2
Diseaseornithine translocase deficiency (implicated_via_orthology)

SLC25A2 SLC25A15

5.08e-062672DOID:0050720 (implicated_via_orthology)
DiseaseEndometrial Stromal Sarcoma

NUTM2B NUTM2A

5.06e-055672C0206630
Diseasecolorectal cancer

BCL9L NID2 SCUBE1 EIF4ENIF1 LRIG1 NKX2-3 CUBN DCAF12

6.64e-05604678MONDO_0005575
Diseasemyeloblastin measurement

PRTN3 AZU1

7.57e-056672EFO_0020585
Diseasecarcinoma (implicated_via_orthology)

FAT4 FLT4 WWTR1

4.22e-0464673DOID:305 (implicated_via_orthology)
Diseasetrimethylamine-N-oxide measurement

TTC13 CUBN

4.54e-0414672EFO_0010541
Diseaseresponse to radiation, Urinary retention

PTPRS LRP1B

6.76e-0417672GO_0009314, HP_0000016
DiseaseVan Buchem disease

HSPG2 LRP5

6.76e-0417672C0432272
Diseasebasophil percentage of granulocytes

PRTN3 AZU1 RYR1

9.03e-0483673EFO_0007995
Diseaseresponse to venlafaxine

CSMD2 DCAF12

1.47e-0325672EFO_0006328
Diseasespontaneous preterm birth

SLIT2 TRMT61B CCKBR

1.59e-03101673EFO_0006917
Diseasecreatinine measurement

LRIG1 SHH KLHDC7A CUBN KIAA1614 RGS12 RYR1 DCAF12

1.82e-03995678EFO_0004518
Diseasechronic kidney disease (biomarker_via_orthology)

FGF23 SHH

1.85e-0328672DOID:784 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
GNFTGLVGGPDFAHC

PPP2R1B

86

P30154
RGHQGEQGLPGFSTS

COL17A1

926

Q9UMD9
CGVGVHFSPGARGLT

EPHA1

386

P21709
GQTSTQPGGSIHFGC

CSMD2

2481

Q7Z408
QNGGSCEPGLHSGFT

FAT4

4436

Q6V0I7
NVGGGFHHCSSDRGG

HDAC11

136

Q96DB2
TCPAGFQTSVQGLGH

CCNJ

316

Q5T5M9
RGSSAGGCRNHPGTF

CAPN11

401

Q9UMQ6
QGGLPGAVHQNGRCR

CCKBR

266

P32239
GFRAGHACGTGTQPQ

DANCR

96

P0C864
GFCEAPGNRTQSGNH

CD82

191

P27701
PQGHAGCHTSFTGQG

PCDH17

826

O14917
SGPRCQQGSGHGIAE

HSPG2

4171

P98160
GFGQHRPGSGQSSGF

FLG2

1101

Q5D862
VAHACNPSTLGGRGG

OR1F12P

311

Q8NHA8
SGTVASGGNLPGVHC

LRCH3

16

Q96II8
GGCSNHCSVVPGRGI

LRP1B

1181

Q9NZR2
GGPQANGHIESNGVC

LRIG1

861

Q96JA1
GGSQHGPFTGIACGK

LRP5

1441

O75197
GGTFGFCVASGNGRP

KIAA1614

1141

Q5VZ46
ACVPGRAGQHRGSAT

PARG

56

Q86W56
GGPGCGGLVTVAHNA

LAMB1

1426

P07942
GHANGQRIGRFCGTF

PCOLCE2

96

Q9UKZ9
QMRGNPGSHFCGGTL

PRTN3

46

P24158
TGSANGGAHNCRPEV

MED26

101

O95402
GQDGPISVHCSAGVG

PTPRS

1871

Q13332
QGNFLPLQCHGSTGF

NID2

966

Q14112
DSPQGHGNSRFQFCG

CUBN

3341

O60494
VHCLGFGPGASGAAA

DSCC1

26

Q9BVC3
REPGGVTQQGCGIHA

DCAF12

131

Q5T6F0
NPTGANLSLFGCHGQ

GALNT4

466

Q8N4A0
RVNTHAGGTGPEGCR

FGF23

231

Q9GZV9
PTCNVGSKGVGAGNH

BCL9L

66

Q86UU0
AQEGHCRPRGAGGQS

LTBP2

1381

Q14767
VACTEGFSQSHGGRP

ITGA10

251

O75578
VPGRASTFGIHQGSC

INSRR

286

P14616
HAGNATVCGFSGGLP

CEP192

1281

Q8TEP8
SGCQGPGHQPSSRVF

KLHDC7A

546

Q5VTJ3
HACATVGNRGFVFGG

KLHDC2

221

Q9Y2U9
LAGGHGVSASRFGPC

FHOD1

636

Q9Y613
ETGCGPHGVTALGQQ

nan

26

Q1T7F1
AHGVASFSLGPCGRG

AZU1

211

P20160
VACGPGTHFGGELGQ

SCUBE1

631

Q8IWY4
GGDFVSPGQQGRISH

RYR1

1496

P21817
ACSAAGGGPFVNVSN

NKX2-3

316

Q8TAU0
PGIGQRNHCSGAGKA

CRLS1

61

Q9UJA2
GSCHIGGNVATNAGG

D2HGDH

196

Q8N465
DGCGPSGAGASNVFV

NUTM2A

191

Q8IVF1
DGCGPSGAGASNVFV

NUTM2B

191

A6NNL0
QHFTAGPGRASGVTC

TRMT2A

351

Q8IZ69
GGCFPGSATVHLEQG

SHH

196

Q15465
QPCQAHLGAKGGSSG

SMIM34

116

A8MWV9
QNGGRTCAALPGGLH

SSPOP

1781

A2VEC9
GPCSVSCGGGHQSRQ

SSPOP

2566

A2VEC9
GAAGGTACVLTGQPF

SLC25A15

16

Q9Y619
GAAGGTACVLTGQPF

SLC25A2

16

Q9BXI2
ITVPGNFQGHSGAQC

SSRP1

326

Q08945
PQRRSFGGGCHVTAA

EIF4ENIF1

116

Q9NRA8
GHPGAAQRGQGDLQC

TNIP2

391

Q8NFZ5
HGGSGFVGGLCQVAA

VPS51

306

Q9UID3
HRQQQEAPAGGGGCS

TTC13

61

Q8NBP0
SGDQGRCGPTHQGSE

TRMT61B

106

Q9BVS5
PSKRGTVGAGCGFNQ

RGS12

521

O14924
GGHNSSSRNDPCRGG

RBMXL3

801

Q8N7X1
GGHLGGQAVGTPNCV

PLEKHG4B

111

Q96PX9
HRQESGFSCKGPGQN

FLT4

1291

P35916
APGQNGTSFHGCIRN

SLIT2

1296

O94813
AHACNPSTLGGQGGR

PKP2

476

Q99959
GSQCGEAFSQIPGHN

ZNF861P

11

O60384
PAVLGAQGFGAGRHC

RNF39

271

Q9H2S5
LGTGAGAAGSPAQQH

WWTR1

96

Q9GZV5
TNVGSHCRGRGGDQP

USP54

526

Q70EL1
CGHNFQAGELGPGTI

SLC8A2

151

Q9UPR5