Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oligosaccharide binding	ITLN2 ITLN1	4.08e-04	20	30	2	GO:0070492
GeneOntologyMolecularFunction	protein tyrosine phosphatase activity	PTPN7 MTMR6 PTPRZ1	4.89e-04	103	30	3	GO:0004725
GeneOntologyMolecularFunction	molecular carrier activity	SCO2 RAN DISP1	5.62e-04	108	30	3	GO:0140104
MousePheno	increased circulating type I collagen C-terminal telopeptide level	ITLN2 ITLN1	4.59e-05	6	25	2	MP:0031074
MousePheno	decreased circulating osteocalcin level	ITLN2 ITLN1	6.41e-05	7	25	2	MP:0030985
MousePheno	decreased osteoblast proliferation	ITLN2 ITLN1	6.41e-05	7	25	2	MP:0030439
MousePheno	increased circulating interleukin-1 alpha level	ITLN2 ITLN1	8.54e-05	8	25	2	MP:0008638
MousePheno	abnormal circulating type I collagen C-terminal telopeptide level	ITLN2 ITLN1	8.54e-05	8	25	2	MP:0031072
MousePheno	abnormal circulating osteocalcin level	ITLN2 ITLN1	2.37e-04	13	25	2	MP:0011922
MousePheno	abnormal osteoblast proliferation	ITLN2 ITLN1	3.18e-04	15	25	2	MP:0030437
MousePheno	abnormal circulating interleukin-1 alpha level	ITLN2 ITLN1	3.18e-04	15	25	2	MP:0008637
MousePheno	decreased diameter of femur	ITLN2 ITLN1	3.63e-04	16	25	2	MP:0008152
MousePheno	abnormal sclerotome morphology	UHRF1 DISP1	4.62e-04	18	25	2	MP:0006029
MousePheno	decreased diameter of long bones	ITLN2 ITLN1	7.59e-04	23	25	2	MP:0008150
MousePheno	increased circulating interleukin-10 level	ITLN2 ITLN1	8.98e-04	25	25	2	MP:0008593
MousePheno	increased bone trabecular spacing	ITLN2 ITLN1	8.98e-04	25	25	2	MP:0013630
MousePheno	abnormal long bone diaphysis morphology	ITLN2 ITLN1	9.72e-04	26	25	2	MP:0004214
Domain	PTPc_motif	PTPN7 MTMR6 PTPRZ1	1.14e-04	59	30	3	SM00404
Domain	Tyr_Pase_cat	PTPN7 MTMR6 PTPRZ1	1.14e-04	59	30	3	IPR003595
Domain	Tyr_Pase_AS	PTPN7 MTMR6 PTPRZ1	2.16e-04	73	30	3	IPR016130
Domain	TYR_PHOSPHATASE_1	PTPN7 MTMR6 PTPRZ1	3.50e-04	86	30	3	PS00383
Domain	TYR_PHOSPHATASE_2	PTPN7 MTMR6 PTPRZ1	3.62e-04	87	30	3	PS50056
Domain	TYR_PHOSPHATASE_dom	PTPN7 MTMR6 PTPRZ1	3.62e-04	87	30	3	IPR000387
Domain	-	PTPN7 MTMR6 PTPRZ1	4.26e-04	92	30	3	3.90.190.10
Domain	Prot-tyrosine_phosphatase-like	PTPN7 MTMR6 PTPRZ1	5.29e-04	99	30	3	IPR029021
Domain	Fibrinogen_C	ITLN2 ITLN1	8.54e-04	27	30	2	PF00147
Domain	FBG	ITLN2 ITLN1	9.86e-04	29	30	2	SM00186
Domain	-	ITLN2 ITLN1	1.06e-03	30	30	2	3.90.215.10
Domain	Fibrinogen_a/b/g_C_1	ITLN2 ITLN1	1.06e-03	30	30	2	IPR014716
Domain	Fibrinogen_a/b/g_C_dom	ITLN2 ITLN1	1.20e-03	32	30	2	IPR002181
Domain	FIBRINOGEN_C_2	ITLN2 ITLN1	1.20e-03	32	30	2	PS51406
Domain	FIBRINOGEN_C_1	ITLN2 ITLN1	1.20e-03	32	30	2	PS00514
Domain	PTPc	PTPN7 PTPRZ1	1.52e-03	36	30	2	SM00194
Domain	TYR_PHOSPHATASE_PTP	PTPN7 PTPRZ1	1.78e-03	39	30	2	PS50055
Domain	PTPase_domain	PTPN7 PTPRZ1	1.97e-03	41	30	2	IPR000242
Domain	Y_phosphatase	PTPN7 PTPRZ1	1.97e-03	41	30	2	PF00102
Pathway	BIOCARTA_RANBP2_PATHWAY	RAN HDAC1	1.78e-04	11	26	2	M22027
Pathway	PID_RANBP2_PATHWAY	RAN HDAC1	1.78e-04	11	26	2	M140
Pubmed	An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse.	UHRF1 PBRM1 HDAC1	4.68e-07	18	30	3	24025402
Pubmed	Loss-of-Function Variants in TBC1D32 Underlie Syndromic Hypopituitarism.	UHRF1 SCO2 NDUFA10 HDAC1	7.14e-07	81	30	4	32060556
Pubmed	Cloning of the novel gene intelectin, which is expressed in intestinal paneth cells in mice.	ITLN2 ITLN1	7.19e-07	2	30	2	9790983
Pubmed	Characterization of an intelectin-1 (Itln1) knockout mouse model.	ITLN2 ITLN1	7.19e-07	2	30	2	36072603
Pubmed	Intelectin1 ameliorates macrophage activation via inhibiting the nuclear factor kappa B pathway.	ITLN2 ITLN1	7.19e-07	2	30	2	34866068
Pubmed	Recognition of microbial glycans by human intelectin-1.	ITLN2 ITLN1	7.19e-07	2	30	2	26148048
Pubmed	Comparative genomic and phylogenetic analyses of the intelectin gene family: implications for their origin and evolution.	ITLN2 ITLN1	7.19e-07	2	30	2	23643964
Pubmed	Human homologs of the Xenopus oocyte cortical granule lectin XL35.	ITLN2 ITLN1	7.19e-07	2	30	2	11181563
Pubmed	Omentin-1 inhibits the development of benign prostatic hyperplasia by attenuating local inflammation.	ITLN2 ITLN1	7.19e-07	2	30	2	38519941
Pubmed	Tetrahydroxystilbene glycoside improves endothelial dysfunction and hypertension in obese rats: The role of omentin-1.	ITLN2 ITLN1	7.19e-07	2	30	2	33647262
Pubmed	Omentin1 ameliorates myocardial ischemia-induced heart failure via SIRT3/FOXO3a-dependent mitochondrial dynamical homeostasis and mitophagy.	ITLN2 ITLN1	7.19e-07	2	30	2	36192726
Pubmed	Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines.	ITLN2 ITLN1	7.19e-07	2	30	2	29619269
Pubmed	Capture of heat-killed Mycobacterium bovis bacillus Calmette-Guérin by intelectin-1 deposited on cell surfaces.	ITLN2 ITLN1	7.19e-07	2	30	2	19179460
Pubmed	Omentin attenuates atherosclerotic lesion formation in apolipoprotein E-deficient mice.	ITLN2 ITLN1	7.19e-07	2	30	2	26714927
Pubmed	Innate BALB/c enteric epithelial responses to Trichinella spiralis: inducible expression of a novel goblet cell lectin, intelectin-2, and its natural deletion in C57BL/10 mice.	ITLN2 ITLN1	7.19e-07	2	30	2	15265922
Pubmed	Activation of ITLN-1 attenuates oxidative stress injury via activating SIRT1/PGC1-α signaling in neuroblastoma cells.	ITLN2 ITLN1	7.19e-07	2	30	2	37882238
Pubmed	Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis.	ITLN2 ITLN1	7.19e-07	2	30	2	28224996
Pubmed	ITLN1 inhibits tumor neovascularization and myeloid derived suppressor cells accumulation in colorectal carcinoma.	ITLN2 ITLN1	7.19e-07	2	30	2	34363021
Pubmed	Omentin prevents myocardial ischemic injury through AMP-activated protein kinase- and Akt-dependent mechanisms.	ITLN2 ITLN1	7.19e-07	2	30	2	24768874
Pubmed	The potential role of omentin-1 in obesity-related metabolic dysfunction-associated steatotic liver disease: evidence from translational studies.	ITLN2 ITLN1	7.19e-07	2	30	2	38082368
Pubmed	Intelectin: a novel lipid raft-associated protein in the enterocyte brush border.	ITLN2 ITLN1	2.16e-06	3	30	2	16866365
Pubmed	Ontogenic changes in lactoferrin receptor and DMT1 in mouse small intestine: implications for iron absorption during early life.	ITLN2 ITLN1	2.16e-06	3	30	2	16936804
Pubmed	Baculovirus expression of mouse lactoferrin receptor and tissue distribution in the mouse.	ITLN2 ITLN1	2.16e-06	3	30	2	15222482
Pubmed	miR-584 mediates post-transcriptional expression of lactoferrin receptor in Caco-2 cells and in mouse small intestine during the perinatal period.	ITLN2 ITLN1	2.16e-06	3	30	2	19665576
Pubmed	UHRF1 downmodulation enhances antitumor effects of histone deacetylase inhibitors in retinoblastoma by augmenting oxidative stress-mediated apoptosis.	UHRF1 HDAC1	2.16e-06	3	30	2	31782885
Pubmed	Omentin-1 drives cardiomyocyte cell cycle arrest and metabolic maturation by interacting with BMP7.	ITLN2 ITLN1	2.16e-06	3	30	2	37344704
Pubmed	Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila.	ITLN2 ITLN1	2.16e-06	3	30	2	36413219
Pubmed	Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection.	ITLN2 ITLN1	4.31e-06	4	30	2	17420014
Pubmed	The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression.	UHRF1 HDAC1	4.31e-06	4	30	2	17934516
Pubmed	Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells.	UHRF1 HDAC1	4.31e-06	4	30	2	20613874
Pubmed	Intelectin is required for IL-13-induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation.	ITLN2 ITLN1	4.31e-06	4	30	2	19965981
Pubmed	Omentin protects against LPS-induced ARDS through suppressing pulmonary inflammation and promoting endothelial barrier via an Akt/eNOS-dependent mechanism.	ITLN2 ITLN1	4.31e-06	4	30	2	27607575
Pubmed	Deficiency of Omentin-1 leads to delayed fracture healing through excessive inflammation and reduced CD31hiEmcnhi vessels.	ITLN2 ITLN1	4.31e-06	4	30	2	34174367
Pubmed	UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity.	UHRF1 HDAC1	4.31e-06	4	30	2	19800870
Pubmed	Strain-specific copy number variation in the intelectin locus on the 129 mouse chromosome 1.	ITLN2 ITLN1	7.18e-06	5	30	2	21324158
Pubmed	ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain.	UHRF1 HDAC1	7.18e-06	5	30	2	15361834
Pubmed	Exosomal RNF157 mRNA from prostate cancer cells contributes to M2 macrophage polarization through destabilizing HDAC1.	RAN HDAC1	7.18e-06	5	30	2	36263220
Pubmed	M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability.	UHRF1 HDAC1	1.08e-05	6	30	2	22411829
Pubmed	UHRF1 inhibits MDR1 gene transcription and sensitizes breast cancer cells to anticancer drugs.	UHRF1 HDAC1	1.08e-05	6	30	2	20037778
Pubmed	DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination.	UHRF1 HDAC1	1.08e-05	6	30	2	21045206
Pubmed	Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex.	BOC DISP1	2.01e-05	8	30	2	33570491
Pubmed	The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity.	RAN HDAC1	5.58e-05	13	30	2	17158748
Pubmed	Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.	PBRM1 HDAC1	9.70e-05	17	30	2	14519686
Pubmed	ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.	RAN HDAC1	1.50e-04	21	30	2	12453419
Pubmed	Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells.	PBRM1 HDAC1	1.96e-04	24	30	2	18454139
Pubmed	Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis.	BOC DISP1	2.13e-04	25	30	2	29475039
Pubmed	Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.	PBRM1 HDAC1	2.31e-04	26	30	2	10778858
Pubmed	Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle.	RAN HDAC1	2.68e-04	28	30	2	28655764
Pubmed	Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.	UHRF1 RNF41	2.68e-04	28	30	2	35474067
Pubmed	REST repression of neuronal genes requires components of the hSWI.SNF complex.	PBRM1 HDAC1	2.68e-04	28	30	2	12192000
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	SUGP1 NIBAN1 MAPRE2 HDAC1	2.78e-04	370	30	4	22922362
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	UHRF1 PBRM1 HDAC1	2.93e-04	150	30	3	28242625
Pubmed	Nuclear Gene-Encoded Leigh Syndrome Spectrum Overview	SCO2 NDUFA10	3.08e-04	30	30	2	26425749
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	UHRF1 PBRM1 HDAC1	3.35e-04	157	30	3	30186101
Pubmed	Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-κB-dependent inflammation response.	UHRF1 SCO2 MTMR6	4.30e-04	171	30	3	36629882
Pubmed	Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation.	PBRM1 HDAC1	4.70e-04	37	30	2	24335282
Pubmed	Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).	PLBD1 NDUFA10	4.96e-04	38	30	2	22952603
Pubmed	Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.	RAN PBRM1 HDAC1	5.16e-04	182	30	3	26527279
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	RAN PBRM1 HDAC1	6.30e-04	195	30	3	19454010
Pubmed	Large-scale structural analysis of the classical human protein tyrosine phosphatome.	PTPN7 PTPRZ1	7.59e-04	47	30	2	19167335
Pubmed	MLF2 Negatively Regulates P53 and Promotes Colorectal Carcinogenesis.	UHRF1 HDAC1	7.92e-04	48	30	2	37438558
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	RAN GNAL PBRM1 RAPH1	8.47e-04	498	30	4	36634849
Interaction	TBC1D32 interactions	UHRF1 SCO2 NDUFA10 HDAC1	9.64e-06	94	29	4	int:TBC1D32
GeneFamily	Fibronectin type III domain containing	BOC PTPRZ1	1.09e-02	160	18	2	555
GeneFamily	Ring finger proteins	UHRF1 RNF41	3.00e-02	275	18	2	58
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HOPC	DOCK1 BOC UHRF1 GNAL PTPRZ1	5.52e-05	366	30	5	M39052
Coexpression	MIKKELSEN_IPS_LCP_WITH_H3K27ME3	ITLN2 ITLN1	6.92e-05	11	30	2	MM844
Coexpression	GSE22229_RENAL_TRANSPLANT_IMMUNOSUPP_THERAPY_VS_HEALTHY_PBMC_DN	UHRF1 PLBD1 RAPH1 ATP6AP2	7.57e-05	199	30	4	M7479
Coexpression	GSE15330_WT_VS_IKAROS_KO_HSC_DN	CDK16 MTMR6 ATP6AP2 HDAC1	7.57e-05	199	30	4	M7036
Coexpression	GSE24726_WT_VS_E2_2_KO_PDC_DAY6_POST_DELETION_DN	ZDHHC14 NIBAN1 RAPH1 MAPRE2	7.72e-05	200	30	4	M8056
Disease	level of intelectin-1 in blood serum	ITLN2 ITLN1	9.99e-07	2	30	2	OBA_2044678
Disease	SLAM family member 7 measurement	ITLN2 ITLN1	1.35e-04	17	30	2	EFO_0008287
Disease	gait measurement	UHRF1 GNAL AGBL2	4.73e-04	150	30	3	EFO_0007680
Disease	Necrotizing encephalopathy, infantile subacute, of Leigh	SCO2 NDUFA10	6.16e-04	36	30	2	C2931891
Disease	Leigh Syndrome due to Mitochondrial Complex V Deficiency	SCO2 NDUFA10	6.16e-04	36	30	2	C1850600
Disease	Leigh Syndrome due to Mitochondrial Complex III Deficiency	SCO2 NDUFA10	6.16e-04	36	30	2	C1850598
Disease	Leigh Syndrome Due To Mitochondrial Complex II Deficiency	SCO2 NDUFA10	6.16e-04	36	30	2	C1850597
Disease	Leigh Syndrome due to Mitochondrial Complex IV Deficiency	SCO2 NDUFA10	6.16e-04	36	30	2	C1850599
Disease	LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY	SCO2 NDUFA10	6.51e-04	37	30	2	C1838951
Disease	bitter beverage consumption measurement	NIBAN1 AGBL2	8.39e-04	42	30	2	EFO_0010089
Disease	Leigh Disease	SCO2 NDUFA10	1.05e-03	47	30	2	C0023264
Disease	Gastrointestinal Stromal Sarcoma	BOC DISP1	1.05e-03	47	30	2	C3179349
Disease	Mitochondrial Diseases	SCO2 NDUFA10	1.14e-03	49	30	2	C0751651
Disease	Gastrointestinal Stromal Tumors	BOC DISP1	1.19e-03	50	30	2	C0238198
Disease	osteoarthritis	RAPH1 MAPRE2 EQTN	1.47e-03	222	30	3	MONDO_0005178
Disease	Schizophrenia	CDK16 GNAL PBRM1 PTPRZ1 HDAC1	1.82e-03	883	30	5	C0036341
Disease	neonatal abstinence syndrome	DOCK1 ZDHHC14	2.79e-03	77	30	2	EFO_0005799
Disease	squamous cell lung carcinoma, family history of lung cancer	ITLN2 ITLN1	3.39e-03	85	30	2	EFO_0000708, EFO_0006953
Disease	colorectal cancer, hormone replacement therapy	NDUFA10 DISP1	3.62e-03	88	30	2	EFO_0003961, MONDO_0005575
Disease	lipoprotein measurement	DOCK1 SUGP1	5.11e-03	105	30	2	EFO_0004732
Disease	non-high density lipoprotein cholesterol measurement	SUGP1 ZNF627 PBRM1 MAPRE2	5.62e-03	713	30	4	EFO_0005689

Protein segments in the cluster

Peptide	Gene	Start	Entry
YKATLANYPFKYADE	DISP1	246	Q96F81
YYDISAKSNYNFEKP	RAN	146	P62826
YYGQDYRNKYKAPTD	RAPH1	451	Q70E73
NANYIRGYDGKEKVY	PTPN7	151	P35236
NNAKSYYKPDSPEYK	PBRM1	121	Q86U86
SDDYKNPGYYDIQAK	ITLN1	131	Q8WWA0
AGKGKYYAVNYPLRD	HDAC1	216	Q13547
QAKYEDLYAFSYNPK	MTMR6	101	Q9Y217
DYINANYVDGYNRPK	PTPRZ1	1781	P23471
YNNYKKDPYSRGDPC	PLBD1	456	Q6P4A8
KFYDDPRSNDGNSYR	NDUFA10	116	O95299
GKSKIEDYFPEYANY	GNAL	291	P38405
AKNPASPYNLAYKYN	ATP6AP2	286	O75787
YYRPTDSDNDSDYKK	BOC	751	Q9BWV1
PTKREEKYGVAFYNY	DOCK1	6	Q14185
SNEEFKTYNYPKYRA	CDK16	391	Q00536
KYYKNNTDDGQQPFY	AGBL2	361	Q5U5Z8
KFYDANYDGKEYDPV	MAPRE2	156	Q15555
YKNPGYYDIQAKDLG	ITLN2	146	Q8WWU7
PYFVDKNFDKAYRGA	DNAJC18	276	Q9H819
DYYAGEAKNRKYNPS	EFHB	426	Q8N7U6
YAPANEKNGNYYKDI	EQTN	51	Q9NQ60
YYENYVAKRIPGKQA	RNF41	271	Q9H4P4
RVYYNAGPKDEDQDY	SCO2	206	O43819
PNSQGYKYYRQKLEE	SUGP1	301	Q8IWZ8
SYENKEAYQRGAAPK	NIBAN1	101	Q9BZQ8
REPNEYQEYGKKSYT	ZNF627	126	Q7L945
EYKSDTGKPYYYNNQ	PRPF40B	141	Q6NWY9
SNKRGKENYNPYSYG	ZDHHC14	291	Q8IZN3
KYAPAEGNRYDGIYK	UHRF1	546	Q96T88