Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	DUF1088	NBEA LRBA	2.40e-05	2	92	2	IPR010508
Domain	DUF1088	NBEA LRBA	2.40e-05	2	92	2	PF06469
Domain	TOM1	TOM1L2 TOM1	7.18e-05	3	92	2	IPR014645
Domain	WD40_repeat_dom	RBBP7 VPS8 WDR27 NBEA ARHGEF10L WDR90 LRBA BRWD1	1.09e-04	297	92	8	IPR017986
Domain	DUF4704	NBEA LRBA	2.38e-04	5	92	2	IPR031570
Domain	DUF4704	NBEA LRBA	2.38e-04	5	92	2	PF15787
Domain	-	RBBP7 VPS8 WDR27 NBEA ARHGEF10L WDR90 LRBA BRWD1	2.38e-04	333	92	8	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	RBBP7 VPS8 WDR27 NBEA ARHGEF10L WDR90 LRBA BRWD1	2.48e-04	335	92	8	IPR015943
Domain	PH_BEACH	NBEA LRBA	3.55e-04	6	92	2	PF14844
Domain	GAT_dom	TOM1L2 TOM1	3.55e-04	6	92	2	IPR004152
Domain	-	TOM1L2 TOM1	3.55e-04	6	92	2	1.20.58.160
Domain	GAT	TOM1L2 TOM1	3.55e-04	6	92	2	PS50909
Domain	GAT	TOM1L2 TOM1	3.55e-04	6	92	2	PF03127
Domain	ENTH_VHS	TOM1L2 TOM1 TTI1	3.85e-04	29	92	3	IPR008942
Domain	WD40_repeat	RBBP7 VPS8 WDR27 NBEA WDR90 LRBA BRWD1	3.93e-04	272	92	7	IPR001680
Domain	WD_REPEATS_1	RBBP7 VPS8 WDR27 NBEA WDR90 LRBA BRWD1	4.47e-04	278	92	7	PS00678
Domain	WD_REPEATS_2	RBBP7 VPS8 WDR27 NBEA WDR90 LRBA BRWD1	4.57e-04	279	92	7	PS50082
Domain	WD_REPEATS_REGION	RBBP7 VPS8 WDR27 NBEA WDR90 LRBA BRWD1	4.57e-04	279	92	7	PS50294
Domain	STAT_TF_DNA-bd_sub	STAT3 STAT5B	4.96e-04	7	92	2	IPR012345
Domain	STAT	STAT3 STAT5B	4.96e-04	7	92	2	IPR001217
Domain	STAT_int	STAT3 STAT5B	4.96e-04	7	92	2	SM00964
Domain	STAT_TF_DNA-bd	STAT3 STAT5B	4.96e-04	7	92	2	IPR013801
Domain	STAT_bind	STAT3 STAT5B	4.96e-04	7	92	2	PF02864
Domain	STAT_int	STAT3 STAT5B	4.96e-04	7	92	2	PF02865
Domain	-	STAT3 STAT5B	4.96e-04	7	92	2	1.10.532.10
Domain	STAT_alpha	STAT3 STAT5B	4.96e-04	7	92	2	PF01017
Domain	-	STAT3 STAT5B	4.96e-04	7	92	2	1.20.1050.20
Domain	STAT_TF_prot_interaction	STAT3 STAT5B	4.96e-04	7	92	2	IPR013799
Domain	STAT_TF_coiled-coil	STAT3 STAT5B	4.96e-04	7	92	2	IPR015988
Domain	-	STAT3 STAT5B	4.96e-04	7	92	2	2.60.40.630
Domain	STAT_TF_alpha	STAT3 STAT5B	6.59e-04	8	92	2	IPR013800
Domain	PH-BEACH_dom	NBEA LRBA	6.59e-04	8	92	2	IPR023362
Domain	-	NBEA LRBA	6.59e-04	8	92	2	2.30.29.40
Domain	PH_BEACH	NBEA LRBA	6.59e-04	8	92	2	PS51783
Domain	ConA-like_dom	COMP COL20A1 NBEA RYR3 LRBA TRIM47	7.48e-04	219	92	6	IPR013320
Domain	VHS	TOM1L2 TOM1	8.45e-04	9	92	2	PS50179
Domain	BEACH	NBEA LRBA	8.45e-04	9	92	2	PS50197
Domain	Beach	NBEA LRBA	8.45e-04	9	92	2	PF02138
Domain	-	NBEA LRBA	8.45e-04	9	92	2	1.10.1540.10
Domain	Beach	NBEA LRBA	8.45e-04	9	92	2	SM01026
Domain	BEACH_dom	NBEA LRBA	8.45e-04	9	92	2	IPR000409
Domain	VHS	TOM1L2 TOM1	8.45e-04	9	92	2	PF00790
Domain	VHS	TOM1L2 TOM1	8.45e-04	9	92	2	SM00288
Domain	VHS_dom	TOM1L2 TOM1	8.45e-04	9	92	2	IPR002014
Domain	PH_dom-like	NBEA NIBAN2 GAB2 ARHGEF10L MTMR7 ASAP2 GAB4 LRBA	1.20e-03	426	92	8	IPR011993
Domain	ARM-type_fold	NBEA VIRMA RYR3 PIK3C2A TTI1 LRBA PPP6R3	1.43e-03	339	92	7	IPR016024
Domain	WD40	RBBP7 WDR27 NBEA WDR90 LRBA BRWD1	1.77e-03	259	92	6	PF00400
Domain	WD40	RBBP7 WDR27 NBEA WDR90 LRBA BRWD1	2.10e-03	268	92	6	SM00320
Domain	Quinoprotein_ADH-like_supfam	VPS8 WDR27 WDR90	2.27e-03	53	92	3	IPR011047
Domain	N2O_reductase_N	RBBP7 VPS8	2.42e-03	15	92	2	IPR011045
Domain	AT_hook	PRR12 BAZ2A	2.75e-03	16	92	2	PF02178
Domain	EF-hand-dom_pair	FKBP9 STAT3 RYR3 STAT5B MACF1 CCAR2	2.95e-03	287	92	6	IPR011992
Domain	PRAME_family	PRAMEF5 PRAMEF6	3.89e-03	19	92	2	IPR026271
Domain	CH	IQGAP2 SYNE1 MACF1	4.05e-03	65	92	3	SM00033
Pathway	REACTOME_SIGNALING_BY_CYTOSOLIC_FGFR1_FUSION_MUTANTS	CNTRL STAT3 GAB2 STAT5B	1.13e-06	18	64	4	M673
Pathway	REACTOME_FGFR1_MUTANT_RECEPTOR_ACTIVATION	CNTRL STAT3 GAB2 STAT5B	1.11e-05	31	64	4	M661
Pathway	REACTOME_SIGNALING_BY_FGFR1_IN_DISEASE	CNTRL STAT3 GAB2 STAT5B	2.54e-05	38	64	4	M27536
Pathway	REACTOME_INTERLEUKIN_15_SIGNALING	STAT3 GAB2 STAT5B	3.13e-05	14	64	3	M27858
Pathway	REACTOME_INTERLEUKIN_7_SIGNALING	STAT3 STAT5B BRWD1	3.91e-05	15	64	3	MM14536
Pathway	REACTOME_SIGNALING_BY_FGFR_IN_DISEASE	CNTRL STAT3 GAB2 STAT5B	1.88e-04	63	64	4	M635
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_JAK_STAT_SIGNALING_PATHWAY	STAT3 STAT5B	2.01e-04	5	64	2	M48987
Pathway	REACTOME_INTERLEUKIN_9_SIGNALING	STAT3 STAT5B	3.01e-04	6	64	2	MM15581
Pathway	REACTOME_INTERLEUKIN_21_SIGNALING	STAT3 STAT5B	3.01e-04	6	64	2	MM15621
Pathway	REACTOME_SIGNALING_BY_CSF3_G_CSF	STAT3 GAB2 STAT5B	3.32e-04	30	64	3	M41825
Pathway	REACTOME_STAT5_ACTIVATION	GAB2 STAT5B	4.20e-04	7	64	2	M27953
Pathway	KEGG_MEDICUS_REFERENCE_EGF_JAK_STAT_SIGNALING_PATHWAY	STAT3 STAT5B	4.20e-04	7	64	2	M47430
Pathway	REACTOME_INTERLEUKIN_7_SIGNALING	STAT3 STAT5B BRWD1	5.73e-04	36	64	3	M542
Pathway	PID_GMCSF_PATHWAY	STAT3 GAB2 STAT5B	5.73e-04	36	64	3	M22
Pathway	WP_IL2_SIGNALING_PATHWAY	STAT3 GAB2 STAT5B GAB4	6.48e-04	87	64	4	MM15915
Pathway	REACTOME_INTERLEUKIN_9_SIGNALING	STAT3 STAT5B	7.16e-04	9	64	2	M27861
Pathway	BIOCARTA_IL22BP_PATHWAY	STAT3 STAT5B	7.16e-04	9	64	2	MM1419
Pathway	BIOCARTA_IL22BP_PATHWAY	STAT3 STAT5B	7.16e-04	9	64	2	M8066
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE	MTMR7 PIK3C2A	8.92e-04	10	64	2	MM14644
Pathway	REACTOME_INTERLEUKIN_21_SIGNALING	STAT3 STAT5B	8.92e-04	10	64	2	M27898
Pathway	REACTOME_STAT5_ACTIVATION_DOWNSTREAM_OF_FLT3_ITD_MUTANTS	GAB2 STAT5B	8.92e-04	10	64	2	M41731
Pathway	WP_IL2_SIGNALING	STAT3 GAB2 STAT5B	9.03e-04	42	64	3	M39536
Pathway	REACTOME_SIGNALING_BY_SCF_KIT	STAT3 GAB2 STAT5B	9.68e-04	43	64	3	M508
Pathway	REACTOME_INTERLEUKIN_2_FAMILY_SIGNALING	STAT3 GAB2 STAT5B	1.03e-03	44	64	3	M1012
Pathway	REACTOME_SIGNALING_BY_LEPTIN	STAT3 STAT5B	1.09e-03	11	64	2	M27195
Pathway	REACTOME_INTERLEUKIN_15_SIGNALING	STAT3 STAT5B	1.09e-03	11	64	2	MM15578
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE	MTMR7 PIK3C2A	1.09e-03	11	64	2	M655
Pathway	WP_IL3_SIGNALING_PATHWAY	STAT3 GAB2 STAT5B GAB4	1.09e-03	100	64	4	MM15879
Pathway	WP_IL6_SIGNALING_PATHWAY	STAT3 GAB2 STAT5B GAB4	1.09e-03	100	64	4	MM15826
Pathway	REACTOME_CHROMOSOME_MAINTENANCE	MIS18BP1 RBBP7 CENPK PPP6R3	1.18e-03	102	64	4	MM15430
Pathway	WP_THYMIC_STROMAL_LYMPHOPOIETIN_TSLP_SIGNALING	STAT3 GAB2 STAT5B	1.25e-03	47	64	3	M39380
Pathway	WP_IL3_SIGNALING	STAT3 GAB2 STAT5B	1.42e-03	49	64	3	M39722
Pathway	REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE	MIS18BP1 RBBP7 CENPK	1.50e-03	50	64	3	MM15308
Pathway	WP_EGFR1_SIGNALING_PATHWAY	RBBP7 STAT3 GAB2 STAT5B GAB4	1.61e-03	188	64	5	MM15828
Pathway	WP_IL4_SIGNALING	STAT3 GAB2 STAT5B	1.88e-03	54	64	3	M39720
Pathway	PID_IL2_1PATHWAY	STAT3 GAB2 STAT5B	1.98e-03	55	64	3	M122
Pathway	WP_FOXP3_IN_COVID19	STAT3 STAT5B	2.05e-03	15	64	2	M42573
Pubmed	Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation.	STAT3 GAB2 GAB4	2.10e-08	3	97	3	19581930
Pubmed	Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement.	GAB2 STAT5B GAB4	8.40e-08	4	97	3	19258595
Pubmed	Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5.	GAB2 STAT5B GAB4	8.40e-08	4	97	3	20161778
Pubmed	A novel Stat3 binding motif in Gab2 mediates transformation of primary hematopoietic cells by the Stk/Ron receptor tyrosine kinase in response to Friend virus infection.	STAT3 GAB2 GAB4	8.40e-08	4	97	3	17353274
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	AMFR IQGAP2 RRP1B BMP2K RBBP7 VPS8 TOM1 CHD4 NCLN PRPF8 STAT3 PIK3C2A CCAR2 EXOC1 UBE3C SDHA PPP6R3	4.61e-07	1440	97	17	30833792
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF5 NLRP7 PRAMEF26 PRAMEF6	1.11e-06	28	97	4	25089626
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	BMP2K VPS8 NBEA PIK3C2A LNPEP MRC2 TBC1D12 LRBA	1.42e-06	285	97	8	34369648
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	NBEA CHD4 PRPF8 LRBA MED23 PPP6R3	1.74e-06	129	97	6	23022380
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	SYNE1 NBEA PCNX4 MRC2 MACF1 EXOC1	4.33e-06	151	97	6	17043677
Pubmed	NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.	RBBP7 CHD4 PPP6R3	4.54e-06	12	97	3	9885572
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	AMFR MIS18BP1 RRP1B BMP2K RBBP7 CHD4 NCLN PRPF8 VIRMA STAT3 MRC2 PTRHD1 MED23 PPP6R3	6.27e-06	1203	97	14	29180619
Pubmed	Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin.	GAB2 GAB4	7.70e-06	2	97	2	20535152
Pubmed	Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth.	STAT3 STAT5B	7.70e-06	2	97	2	20167868
Pubmed	Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells.	GAB2 GAB4	7.70e-06	2	97	2	12640133
Pubmed	The pleckstrin homology domain of Gab-2 is required for optimal interleukin-3 signalsome-mediated responses.	GAB2 GAB4	7.70e-06	2	97	2	16275030
Pubmed	Role of Gab2 in mammary tumorigenesis and metastasis.	GAB2 GAB4	7.70e-06	2	97	2	17310989
Pubmed	Essential role for Gab2 in the allergic response.	GAB2 GAB4	7.70e-06	2	97	2	11449275
Pubmed	The absence of Grb2-associated binder 2 (Gab2) does not disrupt NK cell development and functions.	GAB2 GAB4	7.70e-06	2	97	2	15240750
Pubmed	Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation.	GAB2 GAB4	7.70e-06	2	97	2	9885561
Pubmed	Liver-specific overexpression of Gab2 accelerates hepatocellular carcinoma progression by activating immunosuppression of myeloid-derived suppressor cells.	GAB2 GAB4	7.70e-06	2	97	2	35411035
Pubmed	Requirement of Gab2 for mast cell development and KitL/c-Kit signaling.	GAB2 GAB4	7.70e-06	2	97	2	11861309
Pubmed	G-CSF-dependent neutrophil differentiation requires downregulation of MAPK activities through the Gab2 signaling pathway.	GAB2 GAB4	7.70e-06	2	97	2	32437087
Pubmed	CHD4/NuRD maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5.	CHD4 BAZ2A	7.70e-06	2	97	2	23796711
Pubmed	A role for the scaffolding adapter GAB2 in breast cancer.	GAB2 GAB4	7.70e-06	2	97	2	16369543
Pubmed	Deletion of Gab2 in mice protects against hepatic steatosis and steatohepatitis: a novel therapeutic target for fatty liver disease.	GAB2 GAB4	7.70e-06	2	97	2	27282405
Pubmed	A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid-induced neuronal differentiation.	GAB2 GAB4	7.70e-06	2	97	2	16009726
Pubmed	Reciprocal roles of STAT3 and STAT5 in nasal polyposis.	STAT3 STAT5B	7.70e-06	2	97	2	22959364
Pubmed	Grb2 associated binder 2 couples B-cell receptor to cell survival.	GAB2 GAB4	7.70e-06	2	97	2	18950707
Pubmed	Gab2 is essential for Bcr-Abl-mediated leukemic transformation and hydronephrosis in a chronic myeloid leukemia mouse model.	GAB2 GAB4	7.70e-06	2	97	2	27125306
Pubmed	Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor‑associated macrophages.	GAB2 GAB4	7.70e-06	2	97	2	37937666
Pubmed	STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells.	STAT3 STAT5B	7.70e-06	2	97	2	18577706
Pubmed	Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.	GAB2 GAB4	7.70e-06	2	97	2	26773044
Pubmed	Inhibition of GAB2 expression has a protective effect on osteoarthritis:An in vitro and in vivo study.	GAB2 GAB4	7.70e-06	2	97	2	36007472
Pubmed	STAT3 genetic variant, alone and in combination with STAT5b polymorphism, contributes to breast cancer risk and clinical outcomes.	STAT3 STAT5B	7.70e-06	2	97	2	25487443
Pubmed	Gab2 deficiency suppresses high-fat diet-induced obesity by reducing adipose tissue inflammation and increasing brown adipose function in mice.	GAB2 GAB4	7.70e-06	2	97	2	33637697
Pubmed	A role for KAI1 in promotion of cell proliferation and mammary gland hyperplasia by the gp78 ubiquitin ligase.	AMFR CD82	7.70e-06	2	97	2	20089858
Pubmed	Abnormal hematopoiesis in Gab2 mutant mice.	GAB2 GAB4	7.70e-06	2	97	2	17374739
Pubmed	Gab2 plays distinct roles in bone homeostasis at different time points.	GAB2 GAB4	7.70e-06	2	97	2	17323176
Pubmed	Gab2 (Grb2-Associated Binder2) Plays a Crucial Role in Inflammatory Signaling and Endothelial Dysfunction.	GAB2 GAB4	7.70e-06	2	97	2	33827252
Pubmed	Docking protein Gab2 positively regulates glycoprotein VI-mediated platelet activation.	GAB2 GAB4	7.70e-06	2	97	2	16198316
Pubmed	Growth factor receptor bound protein 2-associated binder 2, a scaffolding adaptor protein, negatively regulates host immunity against tuberculosis.	GAB2 GAB4	7.70e-06	2	97	2	24805943
Pubmed	Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl(+) K562 leukemic cells by Gab2.	GAB2 GAB4	7.70e-06	2	97	2	11830491
Pubmed	The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation.	AMFR CD82	7.70e-06	2	97	2	18037895
Pubmed	Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations.	STAT3 STAT5B	7.70e-06	2	97	2	24512550
Pubmed	Docking protein Gab2 regulates mucin expression and goblet cell hyperplasia through TYK2/STAT6 pathway.	GAB2 GAB4	7.70e-06	2	97	2	22859374
Pubmed	Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells.	STAT3 STAT5B	7.70e-06	2	97	2	25586472
Pubmed	STAT3 and STAT5B mutations have unique distribution in T-cell large granular lymphocyte proliferations and advanced myeloid neoplasms.	STAT3 STAT5B	7.70e-06	2	97	2	33410350
Pubmed	Scaffolding protein Gab2 is involved in postnatal development and lipopolysaccharide-induced activation of microglia in the mouse brain.	GAB2 GAB4	7.70e-06	2	97	2	34146905
Pubmed	Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.	MTSS1 ASAP2 TTI1 SEC14L5	1.39e-05	52	97	4	9455477
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RRP1B RBBP7 CHD4 PRPF8 VIRMA BAZ2A MACF1 CCAR2 SDHA PPP6R3	1.48e-05	653	97	10	22586326
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	UBR2 SYNE1 VPS8 VIRMA BAZ2A MACF1 CCAR2 UBE3C	1.91e-05	407	97	8	12693553
Pubmed	The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia.	NBEA LRBA	2.31e-05	3	97	2	28814779
Pubmed	Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease.	TOM1 LRBA	2.31e-05	3	97	2	31263572
Pubmed	Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.	GAB2 GAB4	2.31e-05	3	97	2	12821647
Pubmed	Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress.	GAB2 GAB4	2.31e-05	3	97	2	30816308
Pubmed	[Expression and clinical significance of COX-2, p-Stat3, and p-Stat5 in esophageal carcinoma].	STAT3 STAT5B	2.31e-05	3	97	2	17672932
Pubmed	Non-redundant roles of the Gab1 and Gab2 scaffolding adapters in VEGF-mediated signalling, migration, and survival of endothelial cells.	GAB2 GAB4	2.31e-05	3	97	2	19233262
Pubmed	Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: preclinical and clinical significance in head and neck cancer.	STAT3 STAT5B	2.31e-05	3	97	2	22194600
Pubmed	Transcriptional activation of signal transducer and activator of transcription (STAT) 3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell.	STAT3 STAT5B	2.31e-05	3	97	2	18276758
Pubmed	Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome.	TOM1L2 TOM1	2.31e-05	3	97	2	23023224
Pubmed	Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia.	STAT3 STAT5B	2.31e-05	3	97	2	20201032
Pubmed	CD82 regulates STAT5/IL-10 and supports survival of acute myelogenous leukemia cells.	STAT5B CD82	2.31e-05	3	97	2	23797738
Pubmed	Multiple cytotoxic factors involved in IL-21 enhanced antitumor function of CIK cells signaled through STAT-3 and STAT5b pathways.	STAT3 STAT5B	2.31e-05	3	97	2	24289584
Pubmed	Osteolytic prostate cancer cells induce the expression of specific cytokines in bone-forming osteoblasts through a Stat3/5-dependent mechanism.	STAT3 STAT5B	2.31e-05	3	97	2	19796718
Pubmed	A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.	GAB2 GAB4	2.31e-05	3	97	2	20651068
Pubmed	Gab2 promotes colony-stimulating factor 1-regulated macrophage expansion via alternate effectors at different stages of development.	GAB2 GAB4	2.31e-05	3	97	2	21930791
Pubmed	Comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat.	GAB2 GAB4	2.31e-05	3	97	2	11701952
Pubmed	IL-2 and IL-7 induce heterodimerization of STAT5 isoforms in human peripheral blood T lymphoblasts.	STAT3 STAT5B	2.31e-05	3	97	2	9398404
Pubmed	The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8.	STAT3 STAT5B	2.31e-05	3	97	2	18342552
Pubmed	The Gab2-MALT1 axis regulates thromboinflammation and deep vein thrombosis.	GAB2 GAB4	2.31e-05	3	97	2	35895897
Pubmed	DARPP32, STAT5 and STAT3 mRNA expression ratios in glioblastomas are associated with patient outcome.	STAT3 STAT5B	2.31e-05	3	97	2	23250732
Pubmed	GRB2-mediated recruitment of GAB2, but not GAB1, to SF-STK supports the expansion of Friend virus-infected erythroid progenitor cells.	GAB2 GAB4	2.31e-05	3	97	2	16314834
Pubmed	Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8+ T-Cell Activation.	GAB2 GAB4	2.31e-05	3	97	2	30936879
Pubmed	Investigation and analysis of single nucleotide polymorphisms in Janus kinase/signal transducer and activator of transcription genes with leukemia.	STAT3 STAT5B	2.31e-05	3	97	2	22126101
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF5 STAT3 PRAMEF6	2.32e-05	20	97	3	21425410
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF5 PRAMEF26 PRAMEF6	3.12e-05	22	97	3	31729367
Pubmed	Tagging genes with cassette-exchange sites.	TOM1L2 MTSS1 SIK1 MACF1 EXOC1 MED23 PPP6R3	4.42e-05	335	97	7	15741177
Pubmed	IL-23 and IL-2 activation of STAT5 is required for optimal IL-22 production in ILC3s during colitis.	STAT3 STAT5B	4.60e-05	4	97	2	32332067
Pubmed	Grb2-associated binder-1 is required for neuregulin-1-induced peripheral nerve myelination.	GAB2 GAB4	4.60e-05	4	97	2	24872569
Pubmed	Differential effects of STAT proteins on growth hormone-mediated IGF-I gene expression.	STAT3 STAT5B	4.60e-05	4	97	2	25205818
Pubmed	Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility.	GAB2 GAB4	4.60e-05	4	97	2	23401857
Pubmed	The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.	STAT3 STAT5B	4.60e-05	4	97	2	7719938
Pubmed	Degradation of the transcription factors NF-κB, STAT3, and STAT5 is involved in Entamoeba histolytica-induced cell death in Caco-2 colonic epithelial cells.	STAT3 STAT5B	4.60e-05	4	97	2	25352693
Pubmed	[Expression and its significance of STAT3, STAT5, Survivin and Ki67 in nasal NK/T cell lymphoma].	STAT3 STAT5B	4.60e-05	4	97	2	17225522
Pubmed	Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.	GAB2 GAB4	4.60e-05	4	97	2	22806893
Pubmed	The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells.	GAB2 GAB4	4.60e-05	4	97	2	20335178
Pubmed	Cutting edge: role of STAT1, STAT3, and STAT5 in IFN-alpha beta responses in T lymphocytes.	STAT3 STAT5B	4.60e-05	4	97	2	15634877
Pubmed	The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo.	GAB2 GAB4	4.60e-05	4	97	2	19171907
Pubmed	Cooperative interaction of hepatocyte growth factor and neuregulin regulates Schwann cell migration and proliferation through Grb2-associated binder-2 in peripheral nerve repair.	GAB2 GAB4	4.60e-05	4	97	2	28722233
Pubmed	Neither signal transducer and activator of transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin's effects on fertility in mice.	STAT3 STAT5B	4.60e-05	4	97	2	23696567
Pubmed	Gab2, via PI-3K, regulates ARF1 in FcεRI-mediated granule translocation and mast cell degranulation.	GAB2 GAB4	4.60e-05	4	97	2	21653832
Pubmed	An oncogenic viral interferon regulatory factor upregulates CUB domain-containing protein 1 to promote angiogenesis by hijacking transcription factor lymphoid enhancer-binding factor 1 and metastasis suppressor CD82.	AMFR CD82	4.60e-05	4	97	2	32555380
Pubmed	Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo.	GAB2 GAB4	4.60e-05	4	97	2	34903841
Pubmed	Tollip coordinates Parkin-dependent trafficking of mitochondrial-derived vesicles.	TOM1L2 TOM1	4.60e-05	4	97	2	32311122
Pubmed	Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer.	STAT3 STAT5B	4.60e-05	4	97	2	17639043
Pubmed	Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.	GAB2 GAB4	4.60e-05	4	97	2	27840422
Pubmed	Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells.	STAT3 EPHA5	4.60e-05	4	97	2	15485908
Pubmed	STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6.	STAT3 STAT5B	4.60e-05	4	97	2	23716595
Pubmed	Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.	GAB2 GAB4	4.60e-05	4	97	2	12058075
Pubmed	The transcriptional STAT3 is a potential target, whereas transcriptional STAT5A/5B/6 are new biomarkers for prognosis in human breast carcinoma.	STAT3 STAT5B	4.60e-05	4	97	2	28422733
Interaction	GOLGA4 interactions	RBBP7 PRPF8 VIRMA ARL5A MACF1 CCAR2 EXOC1 PPP6R3	9.92e-06	226	93	8	int:GOLGA4
Interaction	DNAJC6 interactions	BMP2K VIRMA PIK3C2A SDHA PPP6R3	1.15e-05	64	93	5	int:DNAJC6
Interaction	PCNT interactions	RBBP7 SYNE1 CNTRL CHD4 VIRMA MACF1 EXOC1 CCDC183	1.58e-05	241	93	8	int:PCNT
Interaction	GYPA interactions	TLCD4 VPS8 STAT3 TTI1 EXOC1 UBE3C LRBA	1.61e-05	174	93	7	int:GYPA
Interaction	FAM186B interactions	IQGAP2 VIRMA NEK4	2.03e-05	12	93	3	int:FAM186B
Interaction	EDNRB interactions	VPS8 TYW1B LNPEP EXOC1	3.09e-05	39	93	4	int:EDNRB
Interaction	LUC7L2 interactions	RRP1B RBBP7 CNTRL CHD4 PRPF8 VIRMA STAT3 EXOC1 PPP6R3	3.70e-05	353	93	9	int:LUC7L2
Interaction	NRCAM interactions	VIRMA NEK4 PTPRB MACF1	3.78e-05	41	93	4	int:NRCAM
Cytoband	8p22	MTSS1 MTMR7 CCAR2	8.53e-05	40	97	3	8p22
Cytoband	14q23.1	KIAA0586 LRRC9 PCNX4	1.39e-04	47	97	3	14q23.1
Cytoband	1p36.21	PRAMEF5 PRAMEF26 PRAMEF6	3.31e-04	63	97	3	1p36.21
GeneFamily	PRAME family	PRAMEF5 PRAMEF26 PRAMEF6	7.75e-05	24	63	3	686
GeneFamily	WD repeat domain containing	RBBP7 WDR27 NBEA WDR90 LRBA BRWD1	2.98e-04	262	63	6	362
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEA LRBA	4.23e-04	9	63	2	1230
GeneFamily	PHD finger proteins\|NuRD complex	RBBP7 CHD4	7.71e-04	12	63	2	1305
GeneFamily	Fibronectin type III domain containing	IL31RA COL20A1 PTPRB EPHA5	2.35e-03	160	63	4	555
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	UBR2 TMEM161B LNPEP MACF1 LRBA POLQ	3.88e-06	191	97	6	9454f642c3621370fa23640b631301346b300950
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNE1 NBEA SHOC1 WDR90 SPAG17 DNAH11	4.24e-06	194	97	6	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 STAT3 LNPEP MACF1 LRBA MED23	4.63e-06	197	97	6	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNE1 LRRC9 VWA3B WDR90 SPAG17 DNAH11	4.63e-06	197	97	6	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNE1 TLCD4 RYR3 PIK3C2A MACF1 GPRC5B	5.05e-06	200	97	6	07d942803360e1a1e8e131d6e31c726dd0db1a0b
ToppCell	Control-Epithelial_airway-Ciliated_cells-Ciliated\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NME9 LRRC9 VWA3B SPAG17 DNAH11	2.20e-05	154	97	5	4e3bc24043144143842627cacf6f90dda2228910
ToppCell	Control-Epithelial_airway-Ciliated_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NME9 LRRC9 VWA3B SPAG17 DNAH11	2.20e-05	154	97	5	7556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	ATP8B2 STAT3 LNPEP MACF1 LRBA	2.81e-05	162	97	5	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Ciliated_2\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	NME9 TYW1B VWA3B SPAG17 DNAH11	3.06e-05	165	97	5	731147b4337fd0de4383dc8170b4f9ccd98caec6
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NMNAT2 LRRC9 VWA3B SPAG17 DNAH11	3.44e-05	169	97	5	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	Control-Lymphoid-Tregs\|Lymphoid / Condition, Lineage and Cell class	SIK1 NME9 STAT3 MTMR7 SHOC1	3.95e-05	174	97	5	522a6d5d9809271c63b85f62ac6ec52a6e3c355e
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	CD82 TYW1B PIK3C2A UBE3C PPP6R3	4.06e-05	175	97	5	f3a68aeb79c4935006e17a5ff3445a8ec0e33f5f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 MTSS1 EVC MRC2 DNAH11	4.17e-05	176	97	5	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 MTSS1 EVC MRC2 DNAH11	4.28e-05	177	97	5	da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM161B LRRC9 ABCC8 CCAR2 POLQ	4.28e-05	177	97	5	8abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNTRL SIK1 CHD4 LNPEP MACF1	5.15e-05	184	97	5	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	UBR2 TMEM161B MACF1 LRBA POLQ	5.28e-05	185	97	5	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	UBR2 TMEM161B MACF1 LRBA POLQ	5.42e-05	186	97	5	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIGN IQGAP2 STAT5B MACF1 LRBA	5.99e-05	190	97	5	91ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 MTSS1 EVC MRC2 DNAH11	5.99e-05	190	97	5	b855b8b7d3439023390ca44629c1a99f5d4c6801
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 MTSS1 EVC MRC2 DNAH11	5.99e-05	190	97	5	a5db902ad112a0c0a0a7f1a2e38718bb3bd11412
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZBTB9 EVC ABCC8 WDR90 BRWD1	6.30e-05	192	97	5	d6f656be2698bd215717d35f4e7ab727c08c61e0
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 LNPEP MACF1 LRBA BRWD1	6.46e-05	193	97	5	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	COVID-19-kidney-Glomerular_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SYNE1 MTSS1 PTPRB PIK3C2A GPRC5B	6.61e-05	194	97	5	660535b492445063d965095a50e1e299ce04c50a
ToppCell	moderate-Epithelial-FOXN4+\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MIS18BP1 CNTRL CENPK WDR90 SDHA	6.61e-05	194	97	5	dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	SYNE1 NBEA VWA3B SPAG17 DNAH11	6.78e-05	195	97	5	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	SYNE1 NBEA VWA3B SPAG17 DNAH11	6.78e-05	195	97	5	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NMNAT2 NBEA GAB2 STMN4 ABCC8	7.11e-05	197	97	5	27c044833e471a312a572e0b1c83e4bc8a36e896
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NMNAT2 NBEA GAB2 STMN4 ABCC8	7.11e-05	197	97	5	f7eaac1c321710a55e09ffb047a7db2baf7b7e28
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating-cycling_dorsal_progenitors\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	MIS18BP1 CNTRL KIAA0586 EMC9 CENPK	7.28e-05	198	97	5	5f0964c3aa7e1dc52cbb46e754078920b65bcb88
ToppCell	critical-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SYNE1 CNTRL VWA3B SPAG17 DNAH11	7.28e-05	198	97	5	ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	MIS18BP1 CNTRL KIAA0586 EMC9 CENPK	7.28e-05	198	97	5	629d674a9c9108c1acb3f7af57bbdbf34bb0528e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNE1 MTSS1 CD82 ABCC8 GPRC5B	7.46e-05	199	97	5	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Proliferating-cycling_dorsal_progenitors\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	MIS18BP1 CNTRL KIAA0586 EMC9 CENPK	7.46e-05	199	97	5	ca17e8c0f5bc2c41ce28351a7418d934404e563b
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNE1 MTSS1 CD82 ABCC8 GPRC5B	7.46e-05	199	97	5	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ASAP2 PTPRB PIK3C2A MACF1 BRWD1	7.64e-05	200	97	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	FKBP9 ASAP2 PTPRB MACF1 GPRC5B	7.64e-05	200	97	5	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNE1 TLCD4 RYR3 MACF1 GPRC5B	7.64e-05	200	97	5	d0812817ef99608994193787a62d39adeb2070ca
ToppCell	(09)_Interm._secr.>cil.\|World / shred by cell type by condition	SYNE1 CNTRL VWA3B WDR90 SPAG17	7.64e-05	200	97	5	3305e14dba12e94da42f0414fdc7a2c8caf0a183
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNE1 TLCD4 RYR3 MACF1 GPRC5B	7.64e-05	200	97	5	cd54ddf1919c98e84b7e4aba85b374fc8b407206
Computational	Neighborhood of FOSL1	AMFR PDE4A KIAA0586 OR2B6 RYR3 PTPRB PIK3C2A ABCC8 TTI1	1.45e-04	406	53	9	MORF_FOSL1
Computational	Neighborhood of MSH3	AMFR KIAA0586 OR2B6 PIK3C2A ABCC8 TTI1 BRWD1	1.76e-04	243	53	7	MORF_MSH3
Computational	Neighborhood of BRCA1	AMFR KIAA0586 OR2B6 PIK3C2A ABCC8 TTI1 BRWD1	2.85e-04	263	53	7	MORF_BRCA1
Computational	Neighborhood of ATRX	UBR2 AMFR KIAA0586 PIK3C2A TTI1 MUTYH	6.26e-04	215	53	6	MORF_ATRX
Computational	Neighborhood of HEAB	AMFR KIAA0586 TTI1 MUTYH	7.26e-04	83	53	4	MORF_HEAB
Computational	Neighborhood of PPP5C	AMFR KIAA0586 TTI1 MUTYH	1.03e-03	91	53	4	MORF_PPP5C
Computational	Neighborhood of ATF2	RBBP7 OR2B6 RYR3 PTPRB PIK3C2A ABCC8 BRWD1	1.10e-03	330	53	7	MORF_ATF2
Disease	T-Cell Large Granular Lymphocyte Leukemia	STAT3 STAT5B	9.83e-06	2	93	2	C1955861
Disease	angiosarcoma (is_implicated_in)	STAT3 PTPRB	5.87e-05	4	93	2	DOID:0001816 (is_implicated_in)
Disease	colon adenocarcinoma (is_implicated_in)	CHD4 STAT3 STAT5B	7.48e-05	26	93	3	DOID:234 (is_implicated_in)
Disease	insomnia measurement	VPS8 ZBTB9 WDR27 ARHGEF10L PIK3C2A WDR90 GPRC5B DNAH11	8.10e-05	443	93	8	EFO_0007876
Disease	systemic scleroderma, Crohn's disease	ZBTB9 STAT3	9.77e-05	5	93	2	EFO_0000384, EFO_0000717
Disease	platelet component distribution width	IQGAP2 BMP2K SYNE1 TLCD4 MTSS1 GAB2 BAZ2A MACF1 SEC14L5 BRWD1	1.35e-04	755	93	10	EFO_0007984
Disease	DIABETES MELLITUS, PERMANENT NEONATAL	STAT3 ABCC8	2.04e-04	7	93	2	C1833104
Disease	peripheral arterial disease, traffic air pollution measurement	MTSS1 NBEA MACF1 LRBA MUTYH	3.80e-04	194	93	5	EFO_0004265, EFO_0007908
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Positive	MTSS1 SIK1 STAT3 UBE3C	7.98e-04	131	93	4	C4704862
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Negative	MTSS1 SIK1 STAT3 UBE3C	7.98e-04	131	93	4	C4552091
Disease	Juvenile arthritis	MTSS1 SIK1 STAT3 UBE3C	7.98e-04	131	93	4	C3495559
Disease	Juvenile psoriatic arthritis	MTSS1 SIK1 STAT3 UBE3C	7.98e-04	131	93	4	C3714758
Disease	calcium measurement	GAB2 MTMR7 ASAP2 PCNX4 SLC22A3 SHOC1 MACF1 POLQ	8.39e-04	628	93	8	EFO_0004838
Disease	multiple myeloma, monoclonal gammopathy	TOM1 DNAH11	8.72e-04	14	93	2	EFO_0000203, EFO_0001378
Disease	Juvenile-Onset Still Disease	MTSS1 SIK1 STAT3 UBE3C	8.93e-04	135	93	4	C0087031
Disease	T-Cell Lymphoma	STAT3 STAT5B	1.15e-03	16	93	2	C0079772
Disease	hemoglobin A1 measurement	TOM1L2 NME9 GAB2 ABCC8 SLC22A3 MACF1 UBE3C	1.30e-03	520	93	7	EFO_0007629
Disease	cognitive function measurement	NMNAT2 TMEM161B VPS8 MTSS1 ZBTB9 NBEA NME9 RYR3 PRR12 ASAP2 VWA3B EPHA5	1.81e-03	1434	93	12	EFO_0008354
Disease	bone density, lean body mass	TOM1L2 PPP6R3	1.98e-03	21	93	2	EFO_0003923, EFO_0004995
Disease	fatty acid measurement	UBR2 NEK4 TYW1B SLC22A3 MACF1 BRWD1	2.60e-03	436	93	6	EFO_0005110
Disease	Neonatal diabetes mellitus	STAT3 ABCC8	2.81e-03	25	93	2	C0158981
Disease	Intellectual Disability	SYNE1 NBEA PRR12 PTRHD1 MACF1 MED23	2.94e-03	447	93	6	C3714756

Protein segments in the cluster

Peptide	Gene	Start	Entry
ENIASAMVIWINEIL	TBC1D12	451	O60347
TIMPTLEEWEALCQQ	CCAR2	431	Q8N163
ESVNLTCKQWLQMEE	C2orf16	401	Q68DN1
QNLNMTVAQDWCLAL	ARHGEF10L	681	Q9HCE6
QWCEQVEIADENNML	CNTRL	51	Q7Z7A1
NVEEIVINNTRFLMW	ARL5A	51	Q9Y689
AVLQWVEELEQRVIM	BAZ2A	1516	Q9UIF9
WVVLNQGREIVQTMN	COMP	551	P49747
VCKVMEQNQNNWLLT	EPHA5	101	P54756
LNIADLVIFTWMEVQ	DNAH11	1526	Q96DT5
VNSISDNVWEVLILM	BMP2K	116	Q9NSY1
MQVEVQSLSLEECPW	C7orf33	1	Q8WU49
CMEKVQAWLQENLGI	CD82	216	P27701
ILQQEQWMNVCVGDI	ATP8B2	141	P98198
QWMNVCVGDIIKLEN	ATP8B2	146	P98198
QIQQEQLDSVMDWLT	NCLN	446	Q969V3
WEMLCGNEVQILSNL	NIBAN2	226	Q96TA1
LVILDMCGNIIIWNQ	LRRC9	1026	Q6ZRR7
WEQNVHNIVMVTQCV	PTPRB	1791	P23467
MNWVNDSIIQEFILL	OR2B6	1	P58173
QEWMIKSINNNTAIC	MIS18BP1	386	Q6P0N0
VMQACVAEDQLVVKW	IL31RA	331	Q8NI17
SPVIDQFIECVWQLM	MTMR7	396	Q9Y216
DEQECQIWMSVLQNS	ASAP2	381	O43150
MVWQNTENALLETVI	PCNX4	486	Q63HM2
IDCLINPLQEQMEEW	MTSS1	101	O43312
IMQALCWVHDDLNQV	PIK3C2A	451	O00443
EELDWCLEQLETMQT	PDE4A	236	P27815
NQVVEWFVQIAMALQ	NEK4	106	P51957
QQLNKCIEILNDMVW	MED23	841	Q9ULK4
VELVMLLCSQEWQNS	LRBA	1851	P50851
AVLDLASLQWVAMQC	MRC2	786	Q9UBG0
ASLQWVAMQCDTQLD	MRC2	791	Q9UBG0
QEALEVIQLNIQWME	LNPEP	1001	Q9UIQ6
SAAVQSQLQWMKQLC	MACF1	761	Q9UPN3
PWVICSVSEDNIMQI	RBBP7	386	Q16576
ALCLMLVQVIIAVEW	GPRC5B	166	Q9NZH0
VLLMDIWNSEDQVQI	FKBP9	136	O95302
LQQMIQAVVDNVCWQ	ENOPH1	86	Q9UHY7
FQLQMLQIVCSDTWA	COL20A1	1026	Q9P218
TREDMNEWVQSICQI	GAB4	136	Q2WGN9
AIEACVMWLLENEFI	POLQ	581	O75417
IMQVKCLTAELSQWQ	CENPK	61	Q9BS16
NLELQMEDCEEWRVQ	CCDC183	331	Q5T5S1
MIAWNQNDSIVVTAV	BRWD1	431	Q9NSI6
LCEEENLLQVVWHSM	EXOC1	836	Q9NV70
LSVMLEVALNQVDVW	EMC9	56	Q9Y3B6
LLEQDQQVWMEECAL	EVC	586	P57679
QQVWMEECALSSVLQ	EVC	591	P57679
TGTILQNNMKELWCV	ERCC6L2	311	Q5T890
SWVSELQLELHCQVM	CHD4	556	Q14839
MQESCLIQLRHWLQE	SEC14L5	241	O43304
LVCVNAWMLDLTQAI	SLC22A3	146	O75751
LQVLDLQDVCENFWM	PRAMEF26	6	H0Y7S4
TEEDMNKWVQSICQI	GAB2	101	Q9UQC2
FDINSLWNNLCQIIM	TAS2R39	286	P59534
VADQMTLLQNCWSEL	NR5A1	291	Q13285
DMLAVACVNQWEQLR	TRIM47	371	Q96LD4
CMWVQDEPLLQEELA	RRP1B	61	Q14684
MLWLEQPENIATCIA	PTRHD1	106	Q6GMV3
EMVETQINSVKCWVQ	SYNE1	5326	Q8NF91
TQEMNISLVWCLLVL	TMEM161B	131	Q8NDZ6
MVWNTDLVETLELQN	SDHA	556	P31040
VCNQIDQIMPTWIKD	PWWP3B	616	Q5H9M0
LSWNEIQNCIDMVNA	IQGAP2	431	Q13576
KQWVTLVVDVNQCLE	IQGAP2	536	Q13576
VVELVMLLCSQEWQN	NBEA	1936	Q8NFP9
LQAEMDCELQSSLQW	SIK1B	401	A0A0B4J2F2
LQAEMDCELQSSLQW	SIK1	401	P57059
YKIQELQCQILSWMQ	SHOC1	721	Q5VXU9
MAVWIQAQQLQGEAL	STAT5B	1	P51692
WIRNATVNILEEMNL	NLRP7	66	Q8WX94
AVWVSEVMLQQTQVA	MUTYH	126	Q9UIF7
ITSLDIQQVVLMCWE	VPS8	661	Q8N3P4
IQQVVLMCWENRLYD	VPS8	666	Q8N3P4
DLNWCVISDMEVIEL	STMN4	41	Q9H169
QEEVVQQCMRNQPWL	PRR12	2001	Q9ULL5
SMVSWQDILQQINEI	SPAG17	66	Q6Q759
QICNLVAIDTNQLMW	ABCC8	416	Q09428
VLNVQTVEEVVMWCL	AMFR	136	Q9UKV5
AWVVEIQMLKCRVDN	CLEC4F	116	Q8N1N0
LWQKIHESIVMDLCQ	PRPF8	1581	Q6P2Q9
QVLDLQDVCENFWMV	PRAMEF6	101	Q5VXH4
VWALASMELVIQFQV	WDR90	1461	Q96KV7
EASQTIWVNCQVSME	UBTFL6	356	P0CB48
SQTMICWAQEDQIQD	RYR3	1961	Q15413
QSEDWALNMEICDII	TOM1	26	O60784
VTQACLMEDIEQWLS	TOM1	411	O60784
VVVISNICQMPNAWA	STAT3	461	P40763
QVLDLQDVCENFWMV	PRAMEF5	101	Q5TYX0
QLSWVISCVVLDVMN	TLCD4	216	Q96MV1
QVNISTQELWEEMLS	NME9	11	Q86XW9
LSCLMFVWINIEQET	PIGN	736	O95427
QMWQVVDQCSEILRE	ZBTB9	126	Q96C00
WQEMEEACSTLAQIQ	VWA3B	341	Q502W6
VIMWNLDECREKVLQ	WDR27	96	A2RRH5
QSEDWTLNMEICDII	TOM1L2	26	Q6ZVM7
QENSEIMNSLIESWC	UBR2	1561	Q8IWV8
CQLIERILEAWEMNE	PPP6R3	431	Q5H9R7
LVDWTMQALNLQVAL	VIRMA	431	Q69YN4
SISLWICVQIVIEMQ	TYW1B	31	Q6NUM6
ENSLIQWVEQEIMSR	KIAA0586	921	Q9BVV6
WLRMFDQQEIQVLIS	UBE3C	951	Q15386
TICSMNSNIWQICIQ	TTI1	616	O43156
RLIMCQLAVQNSDWI	NMNAT2	66	Q9BZQ4