Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	apyrase activity	ENTPD8 ENTPD3	1.00e-05	3	37	2	GO:0004050
GeneOntologyMolecularFunction	phosphatidylinositol phospholipase C activity	CASR PLCG1 PLCE1	1.48e-05	26	37	3	GO:0004435
GeneOntologyMolecularFunction	phospholipase C activity	CASR PLCG1 PLCE1	2.07e-05	29	37	3	GO:0004629
GeneOntologyMolecularFunction	UDP phosphatase activity	ENTPD8 ENTPD3	1.19e-04	9	37	2	GO:0045134
GeneOntologyMolecularFunction	GDP phosphatase activity	ENTPD8 ENTPD3	2.18e-04	12	37	2	GO:0004382
GeneOntologyMolecularFunction	nucleoside diphosphate phosphatase activity	ENTPD8 ENTPD3	6.22e-04	20	37	2	GO:0017110
GeneOntologyMolecularFunction	phosphoric ester hydrolase activity	CASR PLCG1 FIG4 ENTPD3 PLCE1	6.89e-04	386	37	5	GO:0042578
GeneOntologyMolecularFunction	phosphoric diester hydrolase activity	CASR PLCG1 PLCE1	7.66e-04	97	37	3	GO:0008081
GeneOntologyMolecularFunction	ubiquitin binding	RNFT1 OTUB2 PLAA	1.02e-03	107	37	3	GO:0043130
GeneOntologyMolecularFunction	exopeptidase activity	AGBL4 DPP10 ANPEP	1.10e-03	110	37	3	GO:0008238
GeneOntologyMolecularFunction	phospholipase activity	CASR PLCG1 PLCE1	1.22e-03	114	37	3	GO:0004620
GeneOntologyMolecularFunction	ubiquitin-like protein binding	RNFT1 OTUB2 PLAA	1.70e-03	128	37	3	GO:0032182
GeneOntologyMolecularFunction	lipase activity	CASR PLCG1 PLCE1	2.11e-03	138	37	3	GO:0016298
Domain	GDA1_CD39	ENTPD8 ENTPD3	1.06e-04	8	37	2	PF01150
Domain	GDA1_CD39_NTPASE	ENTPD8 ENTPD3	1.06e-04	8	37	2	PS01238
Domain	GDA1_CD39_NTPase	ENTPD8 ENTPD3	1.06e-04	8	37	2	IPR000407
Domain	PIPLC_Y_DOMAIN	PLCG1 PLCE1	3.95e-04	15	37	2	PS50008
Domain	PI-PLC_fam	PLCG1 PLCE1	3.95e-04	15	37	2	IPR001192
Domain	PLC_EF-hand-like	PLCG1 PLCE1	3.95e-04	15	37	2	IPR015359
Domain	PI-PLC-Y	PLCG1 PLCE1	3.95e-04	15	37	2	PF00387
Domain	PLipase_C_Pinositol-sp_Y	PLCG1 PLCE1	3.95e-04	15	37	2	IPR001711
Domain	EF-hand_like	PLCG1 PLCE1	3.95e-04	15	37	2	PF09279
Domain	PLCYc	PLCG1 PLCE1	3.95e-04	15	37	2	SM00149
Domain	PI-PLC-X	PLCG1 PLCE1	5.73e-04	18	37	2	PF00388
Domain	PLCXc	PLCG1 PLCE1	5.73e-04	18	37	2	SM00148
Domain	PIPLC_X_DOMAIN	PLCG1 PLCE1	6.39e-04	19	37	2	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCG1 PLCE1	6.39e-04	19	37	2	IPR000909
Domain	-	PLCG1 PLCE1	1.11e-03	25	37	2	3.20.20.190
Domain	PLC-like_Pdiesterase_TIM-brl	PLCG1 PLCE1	1.11e-03	25	37	2	IPR017946
Domain	CH	MICALL2 SPTBN2	7.34e-03	65	37	2	SM00033
Domain	CH	MICALL2 SPTBN2	8.47e-03	70	37	2	PF00307
Domain	-	MICALL2 SPTBN2	8.71e-03	71	37	2	1.10.418.10
Domain	CH	MICALL2 SPTBN2	9.19e-03	73	37	2	PS50021
Domain	CH-domain	MICALL2 SPTBN2	9.68e-03	75	37	2	IPR001715
Domain	PH_dom-like	PLCG1 WDFY4 SPTBN2 PLCE1	9.73e-03	426	37	4	IPR011993
Pathway	REACTOME_PHOSPHATE_BOND_HYDROLYSIS_BY_NTPDASE_PROTEINS	ENTPD8 ENTPD3	1.22e-04	8	30	2	M27737
Pathway	REACTOME_PHOSPHATE_BOND_HYDROLYSIS_BY_NTPDASE_PROTEINS	ENTPD8 ENTPD3	1.22e-04	8	30	2	MM15486
Pathway	WP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY	PLCG1 FIG4 PLCE1	1.24e-04	46	30	3	M48317
Pathway	WP_GPR40_PATHWAY	PLCG1 PLCE1	4.52e-04	15	30	2	M39526
Pathway	WP_PRIMARY_FOCAL_SEGMENTAL_GLOMERULOSCLEROSIS_FSGS	PLCG1 ITGB4 PLCE1	4.70e-04	72	30	3	M39403
Pathway	WP_PRIMARY_FOCAL_SEGMENTAL_GLOMERULOSCLEROSIS_FSGS	PLCG1 ITGB4 PLCE1	4.89e-04	73	30	3	MM15906
Pubmed	Expression of phospholipase C isozymes in human breast cancer and their clinical significance.	PLCG1 PLCE1	3.48e-06	3	38	2	28112359
Pubmed	Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8.	ENTPD8 ENTPD3	6.96e-06	4	38	2	18404504
Pubmed	Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists.	ENTPD8 ENTPD3	6.96e-06	4	38	2	17727821
Pubmed	Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.	PLCG1 PLCE1	4.16e-05	9	38	2	7589147
Pubmed	Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.	PLCG1 PLCE1	4.16e-05	9	38	2	10501179
Pubmed	Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene).	SLC12A2 SPTBN2	7.62e-05	12	38	2	21705333
Pubmed	Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development.	SLC12A2 ANPEP	1.05e-04	14	38	2	36573432
Pubmed	Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.	PLCG1 PLCE1	1.76e-04	18	38	2	1979339
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	ITGB4 SPTBN2	1.76e-04	18	38	2	12119179
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ZFYVE26 CABIN1 SPTBN2	2.03e-04	104	38	3	9205841
Pubmed	Evolutionarily conserved regulators of tau identify targets for new therapies.	TMEM30A PFKL PLAA SLC12A2 HM13	2.36e-04	516	38	5	36610398
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	RNFT1 TMEM30A SLC12A2 HM13 ANPEP FKTN ITGB4	2.84e-04	1201	38	7	35696571
Pubmed	HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.	PLCG1 PLCE1	2.90e-04	23	38	2	9730685
Pubmed	The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.	PLCG1 PLCE1	2.90e-04	23	38	2	9278385
Pubmed	Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.	PLCG1 PLCE1	3.16e-04	24	38	2	10843712
Pubmed	Mechanism of HIV-1-TAT induction of interleukin-1beta from human monocytes: Involvement of the phospholipase C/protein kinase C signaling cascade.	PLCG1 PLCE1	4.01e-04	27	38	2	20336759
Pubmed	Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21.	PFKL CABIN1	6.38e-04	34	38	2	10613844
Pubmed	Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.	PLCG1 PLCE1	7.97e-04	38	38	2	12482669
Pubmed	Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.	WDFY4 TET3	7.97e-04	38	38	2	23273568
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	PLCG1 PFKL PLAA CPLANE1 WDFY4 ITGB4	1.06e-03	1084	38	6	11544199
Pubmed	Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.	ZFYVE26 SLC12A2	1.07e-03	44	38	2	27534441
Pubmed	Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).	PFKL SLC12A2 ANPEP ITGB4	1.09e-03	417	38	4	19199708
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLCG1 PLCE1	3.35e-04	19	26	2	832
GeneFamily	Phospholipases	PLCG1 PLCE1	1.65e-03	42	26	2	467
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	GPR12 SLC12A2 ELFN2	2.17e-03	181	26	3	694
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ABCG2 ANPEP ITGB4	1.84e-02	394	26	3	471
GeneFamily	Fibronectin type III domain containing	ELFN2 ITGB4	2.20e-02	160	26	2	555
Coexpression	GSE3203_UNTREATED_VS_IFNB_TREATED_LN_BCELL_DN	OTUB2 ABCG2 SLC12A2 MICALL2 WDFY4	1.01e-05	200	38	5	M6789
CoexpressionAtlas	DevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#3_top-relative-expression-ranked_500	PFKL SLC12A2 CPLANE1 SCAI	2.15e-05	97	36	4	gudmap_developingGonad_e18.5_ovary_500_k3
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#2_top-relative-expression-ranked_500	PLAA SLC12A2 CPLANE1 SCAI	3.17e-05	107	36	4	gudmap_developingGonad_e14.5_ epididymis_500_k2
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#3_top-relative-expression-ranked_1000	PFKL PLAA SLC12A2 CPLANE1 SCAI	3.69e-05	225	36	5	gudmap_developingGonad_e14.5_ ovary_1000_k3
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_500	PFKL PLAA SLC12A2 HM13 CPLANE1 SCAI	6.20e-05	413	36	6	gudmap_developingGonad_e14.5_ epididymis_500
CoexpressionAtlas	DevelopingGonad_P2_ovary_emap-30224_k-means-cluster#2_top-relative-expression-ranked_500	SLC12A2 CPLANE1 SCAI	1.82e-04	65	36	3	gudmap_developingGonad_P2_ovary_500_k2
CoexpressionAtlas	DevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#2_top-relative-expression-ranked_1000	PLAA SLC12A2 HM13 CPLANE1 SCAI	2.02e-04	323	36	5	gudmap_developingGonad_e11.5_ovary + mesonephros_k2_1000
CoexpressionAtlas	Myeloid Cells, DC.4+.Sp, CD11b CD45 CD4 CD11c CD8a, Spleen, avg-1	SLC12A2 ANPEP WDFY4	2.89e-04	76	36	3	GSM538248_100
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-SMG_basal_1\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	GPR12 SLC12A2 ITGB4 SPTBN2 MGAM2	2.29e-07	158	38	5	adad97e6cf479d42791c5ba9cbc5f15f469322bf
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_2\|368C / Donor, Lineage, Cell class and subclass (all cells)	RNFT1 OTUB2 ANPEP TET3 TICAM1	3.39e-07	171	38	5	26b34dc069cc15b75a0c13cb8c5d81e074788160
ToppCell	Entopeduncular\|World / BrainAtlas - Mouse McCarroll V32	SLC12A2 TMEM80 ITGB4 PLCE1	1.03e-05	160	38	4	833763c8608de4ee6003b8fb682aa9c83d7dea9b
Drug	3-Acetylcoumarin [3949-36-8]; Down 200; 21.2uM; PC3; HT_HG-U133A	PLCG1 CABIN1 MICALL2 SPTBN2 ENTPD3	1.33e-05	195	36	5	4664_DN
Drug	Nalidixic acid sodium salt hydrate; Down 200; 14.6uM; PC3; HT_HG-U133A	RNFT1 PLCG1 PLAA TMEM80 ITGB4	1.47e-05	199	36	5	3668_DN
Drug	ADP beta S	PLCG1 ANPEP ENTPD3 PLCE1	1.58e-05	96	36	4	CID005310996
Drug	2-chloroadenosine	CASR PLCG1 ENTPD3 PLCE1	2.00e-05	102	36	4	CID000008974
Drug	hexachlorocyclopentadiene	CASR ANPEP	2.42e-05	5	36	2	CID000006478
Drug	riboxin	PFKL ENTPD8 ENTPD3	2.50e-05	36	36	3	CID000006831
Disease	HWESASXX measurement	DPP10 ANPEP	3.38e-05	7	38	2	EFO_0021147
Disease	Autism Spectrum Disorders	GABRQ DPP10 TET3	1.81e-04	85	38	3	C1510586
Disease	Movement Disorders	SLC12A2 TET3	6.41e-04	29	38	2	C0026650
Disease	nephrolithiasis	CASR ABCG2	8.31e-04	33	38	2	EFO_0004253
Disease	Inherited neuropathies	ZFYVE26 SPTBN2	1.22e-03	40	38	2	C0598589

Protein segments in the cluster

Peptide	Gene	Start	Entry
YTHLRISYNVYLAVY	CASR	411	P41180
VDRYLSLYYALTYHS	GPR12	136	P47775
IHEYISGYYRVSSYF	ABCG2	456	Q9UNQ0
ASYLHTFAYQNTIYL	ANPEP	501	P15144
KQIFHYSYTASYVIY	DPP10	146	Q8N608
YSYTASYVIYNIHTR	DPP10	151	Q8N608
SLYGYVYTLYTHSFQ	ENTPD3	246	O75355
VYLLYKTSHYNILYA	OTUB2	216	Q96DC9
YTLLPYLYTLFYHAH	MGAM2	666	Q2M2H8
RLYGSDYSVYTHSYL	ENTPD8	231	Q5MY95
LSLLEYVYINYLFYS	GABRQ	341	Q9UN88
IYYKTISYYNHIDSL	LIPJ	331	Q5W064
LTYVSQYYNYFHGRS	MICALL2	96	Q8IY33
YGSAIYTYLQSIHNY	OR2Y1	251	Q8NGV0
HDYYTTEFLYNLYSS	PFKL	631	P17858
NTHTYFYTSFAAYIF	HM13	286	Q8TCT9
TNYSYSYYEKLHTYF	ITGB4	326	P16144
HYKSLYRLAFLYTYS	CABIN1	1526	Q9Y6J0
RYYLSLLYCHLYSYN	CPLANE1	871	Q9H799
SNFYFSYSYDLSHSL	FIG4	161	Q92562
VIYYYAAAQTTHTTY	CENPJ	1206	Q9HC77
YCYTLEVSFYSYIIS	AGBL4	396	Q5VU57
YSLNVTYNYPVHYFD	TMEM30A	291	Q9NV96
TSSAFLLFQLYYYKH	FKTN	16	O75072
FYLSGTYYALYFLAT	TMEM80	96	Q96HE8
LPLSYYYIESSHNTY	PLCE1	1396	Q9P212
AYLLYSLHLNSCLYY	CNGB1	796	Q14028
SVLLYYTFHSQSLYY	RNFT1	216	Q5M7Z0
YTFHSQSLYYSLIFL	RNFT1	221	Q5M7Z0
YYLQNQHTYFSLTLL	XKR7	81	Q5GH72
EKSIITYVATYYHYF	SPTBN2	266	O15020
LNAAYSAYLQSYLSY	TICAM1	566	Q8IUC6
HQHYYYDTHTNTYYL	SLC12A2	196	P55011
VYYGHTNYIYSISVF	PLAA	226	Q9Y263
YYTHYSSAIIVASYL	WDFY4	2631	Q6ZS81
YPHYFVLTSSKIYYS	PLCG1	506	P19174
GQLYYHYYLRTSETS	SCAI	131	Q8N9R8
SVYSYHSYYAQPSLT	TET3	1256	O43151
YLHNYSTNLAIISFY	ZFYVE26	2166	Q68DK2
STYSQLSPRHYYSGY	ELFN2	741	Q5R3F8
SEPYSIYTYRYFIHN	NAA30	236	Q147X3