Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNHD1 DNAH8 DNAH14

5.60e-0518843GO:0008569
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNHD1 DNAH8 DNAH14

2.18e-0428843GO:0051959
GeneOntologyMolecularFunctionclathrin light chain binding

CLTCL1 CLTC

3.62e-047842GO:0032051
GeneOntologyMolecularFunctionIgG receptor activity

FCGR2C FCGR2B

3.62e-047842GO:0019770
GeneOntologyMolecularFunctionsnoRNA binding

BYSL HEATR1 PRKDC

3.91e-0434843GO:0030515
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNHD1 DNAH8 DNAH14

5.03e-0437843GO:0045505
GeneOntologyMolecularFunctionIgG binding

FCGR2C FCGR2B

9.38e-0411842GO:0019864
GeneOntologyCellularComponentintracellular protein-containing complex

PRAMEF7 POLR3B FBH1 RARS1 DCAF8L2 LARS1 PRKDC FBXO32 TAF6 PRAMEF8 TOPORS DICER1 TRAPPC9

1.13e-049728313GO:0140535
MousePhenoincreased chromosomal stability

ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C

4.89e-096614MP:0010095
DomainSCAN_BOX

ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C ZNF215 ZKSCAN5 ZNF287

6.62e-0958837PS50804
DomainSCAN

ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C ZNF215 ZKSCAN5 ZNF287

6.62e-0958837PF02023
DomainSCAN_dom

ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C ZNF215 ZKSCAN5 ZNF287

6.62e-0958837IPR003309
DomainRetrov_capsid_C

ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C ZNF215 ZKSCAN5 ZNF287

7.49e-0959837IPR008916
DomainSCAN

ZSCAN5B ZSCAN5A ZSCAN5C ZNF215 ZKSCAN5 ZNF287

1.74e-0756836SM00431
DomainClathrin_H-chain_propeller_rpt

CLTCL1 CLTC

1.95e-052832IPR022365
DomainClathrin-link

CLTCL1 CLTC

1.95e-052832PF09268
Domain-

CLTCL1 CLTC

1.95e-0528322.130.10.110
DomainClathrin_H-chain_link/propller

CLTCL1 CLTC

1.95e-052832IPR016025
DomainClathrin_propel

CLTCL1 CLTC

1.95e-052832PF01394
DomainClathrin_heavy_chain

CLTCL1 CLTC

1.95e-052832IPR016341
DomainClathrin_H-chain_linker_core

CLTCL1 CLTC

1.95e-052832IPR015348
DomainClathrin_H-chain_propeller_N

CLTCL1 CLTC

1.95e-052832IPR001473
DomainDynein_HC_stalk

DNHD1 DNAH8 DNAH14

2.97e-0514833IPR024743
DomainMT

DNHD1 DNAH8 DNAH14

2.97e-0514833PF12777
DomainDHC_fam

DNHD1 DNAH8 DNAH14

3.70e-0515833IPR026983
DomainDynein_heavy_dom

DNHD1 DNAH8 DNAH14

3.70e-0515833IPR004273
DomainDynein_heavy

DNHD1 DNAH8 DNAH14

3.70e-0515833PF03028
DomainClathrin_H-chain_linker

CLTCL1 CLTC

5.84e-053832IPR012331
DomainCLH

CLTCL1 CLTC

5.84e-053832SM00299
DomainClathrin

CLTCL1 CLTC

4.04e-047832PF00637
DomainCHCR

CLTCL1 CLTC

4.04e-047832PS50236
DomainClathrin_H-chain/VPS_repeat

CLTCL1 CLTC

5.37e-048832IPR000547
DomainTPR-like_helical_dom

CFAP54 CLTCL1 CLTC PRKDC TTC3 ZMYND12

5.99e-04233836IPR011990
DomainARM-type_fold

CLTCL1 CLTC LRRK2 HEATR5A HEATR1 PRKDC TAF6

7.77e-04339837IPR016024
DomainLeu-rich_rpt_4

LRRK2 LRRIQ4

8.58e-0410832IPR025875
DomainLRR_4

LRRK2 LRRIQ4

8.58e-0410832PF12799
Domain-

RARS1 LARS1

1.05e-03118321.10.730.10
DomainDynein_heavy_chain_D4_dom

DNAH8 DNAH14

1.72e-0314832IPR024317
DomainDynein_heavy_dom-2

DNHD1 DNAH8

1.72e-0314832IPR013602
DomainDHC_N2

DNHD1 DNAH8

1.72e-0314832PF08393
DomainAAA_8

DNAH8 DNAH14

1.72e-0314832PF12780
DomaintRNAsynth_Ia_anticodon-bd

RARS1 LARS1

1.97e-0315832IPR009080
DomainSMAD_dom-like

IRF7 SMAD7

2.25e-0316832IPR017855
Domain-

IRF7 SMAD7

2.25e-03168322.60.200.10
Domain-

CFAP54 CLTCL1 CLTC TTC3 ZMYND12

2.30e-032078351.25.40.10
Domainaa-tRNA-synth_I_CS

RARS1 LARS1

2.85e-0318832IPR001412
Domain-

PRAMEF7 NLRP9 LRRK2 LRRIQ4 PRAMEF8 NLRP13

3.06e-033218363.80.10.10
Domain-

LRRK2 HEATR5A HEATR1 PRKDC TAF6

3.11e-032228351.25.10.10
DomainPRAME_family

PRAMEF7 PRAMEF8

3.18e-0319832IPR026271
DomainAA_TRNA_LIGASE_I

RARS1 LARS1

3.18e-0319832PS00178
DomainL_dom-like

PRAMEF7 NLRP9 LRRK2 LRRIQ4 PRAMEF8 NLRP13

3.41e-03328836IPR032675
DomainHEAT_REPEAT

HEATR5A HEATR1 PRKDC

3.74e-0370833PS50077
DomainDAPIN

NLRP9 NLRP13

4.25e-0322832PS50824
DomainPYRIN

NLRP9 NLRP13

4.25e-0322832PF02758
DomainDAPIN

NLRP9 NLRP13

4.25e-0322832IPR004020
DomainPYRIN

NLRP9 NLRP13

4.25e-0322832SM01289
DomainTPR-contain_dom

VPS13A PRKDC TTC3 ZMYND12

4.49e-03150834IPR013026
DomainNACHT

NLRP9 NLRP13

4.65e-0323832PS50837
Pubmed

Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis.

ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C

3.48e-11486431155506
Pubmed

ZSCAN5B and primate-specific paralogs bind RNA polymerase III genes and extra-TFIIIC (ETC) sites to modulate mitotic progression.

ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C

3.48e-11486427732952
Pubmed

ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.

PRAMEF7 ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C PRAMEF8

6.99e-095886631598710
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

PRAMEF7 ZSCAN5B MMS22L ZSCAN5DP ZSCAN5A ZSCAN5C PRAMEF8 BIRC6 EDNRA

3.02e-0736386914691545
Pubmed

NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance.

ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C

1.19e-063286438060382
Pubmed

Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.

CLTCL1 CLTC

6.04e-0628628733129
Pubmed

Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.

FCGR2C FCGR2B

6.04e-0628622531080
Pubmed

Effects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice.

PRKDC HR

6.04e-06286221525235
Pubmed

CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.

CLTCL1 CLTC

6.04e-06286229097553
Pubmed

Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene.

FCGR2C FCGR2B

6.04e-0628629516136
Pubmed

The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.

CLTCL1 CLTC

6.04e-06286220065094
Pubmed

Identification of potential protein interactors of Lrrk2.

CLTC LRRK2 PRKDC

6.50e-061586317400507
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

THEMIS2 PRAMEF7 MMS22L UPB1 RARS1 VPS13A LARS1 YDJC IRF7 GSTO2 PRAMEF8 TRAPPC9 ZNF287

1.12e-051242861330973865
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

ARHGEF40 CLTCL1 GPATCH1 CLTC HEATR1 PRKDC

1.14e-0520286624639526
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

POLR3B FBH1 MAP1S TRIO USP32 CLTC LARS1 PRKDC TAF6 TTC3 KANK2 ZKSCAN5 DKK3

1.60e-051285861335914814
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ARHGEF40 ATG10 CLTCL1 MAP1S TRIO PFAS PRKDC TTC3 BIRC6 TRAPPC9 SMAD7 HR

1.75e-051105861235748872
Pubmed

Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.

CLTCL1 CLTC

1.81e-05386219509056
Pubmed

LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson's disease.

CLTC LRRK2

1.81e-05386229735704
Pubmed

Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo.

FCGR2B PRKDC

1.81e-05386222065769
Pubmed

Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.

CLTCL1 CLTC

1.81e-05386222891263
Pubmed

Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus.

FCGR2C FCGR2B

1.81e-05386223261299
Pubmed

Functional Fcgamma receptor polymorphisms are associated with human allergy.

FCGR2C FCGR2B

1.81e-05386224586589
Pubmed

Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.

CLTCL1 CLTC

1.81e-05386215133132
Pubmed

Nonallelic homologous recombination of the FCGR2/3 locus results in copy number variation and novel chimeric FCGR2 genes with aberrant functional expression.

FCGR2C FCGR2B

1.81e-05386226133275
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

TDRKH ARFGAP3 GPATCH1 CLTC LRRK2 VPS13A ANKRD28 PRKDC MARVELD2 BIRC6

2.24e-05777861035844135
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

RLF ARHGEF40 POLR3B RARS1 CLTC LARS1 BYSL ANKRD28 PFAS SAMM50 HEATR1 PRKDC BIRC6

2.74e-051353861329467282
Pubmed

FcγRIIb and BAFF differentially regulate peritoneal B1 cell survival.

FCGR2B PRKDC

3.61e-05486222516957
Pubmed

Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice.

FCGR2B HR

3.61e-05486216920988
Pubmed

FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells.

FCGR2B PRKDC

3.61e-05486236759517
Pubmed

HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.

CLTCL1 CLTC

3.61e-05486211517213
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF7 NLRP9 PRAMEF8

4.57e-052886325089626
Pubmed

Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors.

HEATR1 PRKDC DICER1

5.65e-053086334017080
Pubmed

Autoimmune thyroiditis in Fcgamma receptor-deficient nonobese diabetic mice.

FCGR2B PRKDC

6.01e-05586219447681
Pubmed

The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells.

MMS22L PRKDC

6.01e-05586229478807
Pubmed

SNPs of Fc-gamma receptor genes and chronic periodontitis.

FCGR2C FCGR2B

6.01e-05586220439936
Pubmed

Copy number, linkage disequilibrium and disease association in the FCGR locus.

FCGR2C FCGR2B

6.01e-05586220508037
Pubmed

Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.

CLTCL1 CLTC

6.01e-05586210436022
Pubmed

MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3.

PRKDC DICER1

6.01e-05586220956382
Pubmed

Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B.

FCGR2C FCGR2B

6.01e-05586219309690
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

POLR3B MAP1S CLTC LARS1 PFAS HEATR1 PRKDC BIRC6 DNAH8

6.22e-0570486929955894
Pubmed

TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.

RARS1 CLTC LARS1 PFAS PRKDC

8.49e-0517986536261009
Pubmed

Wnt antagonist gene polymorphisms and renal cancer.

DKK3 SMAD7

9.01e-05686219562778
Pubmed

Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcγR-Deficient Human IL-15 Transgenic Mouse.

FCGR2B PRKDC

1.26e-04786233117338
Pubmed

The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection.

CCNO DICER1

1.26e-04786223849790
Pubmed

A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.

CLTCL1 CLTC

1.26e-04786219478182
Pubmed

Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.

RLF ATG10 RARS1 LARS1 PFAS HEATR1 TAF6

1.36e-0445486733226137
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

ARHGEF40 TRIO CLTC PRKDC DICER1

1.50e-0420286533005030
Pubmed

Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases.

RARS1 LARS1

1.68e-04886210913161
Pubmed

Genetically determined murine models of immunodeficiency.

PRKDC HR

1.68e-0488623297105
Pubmed

Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents.

RARS1 LARS1

1.68e-0488621651330
Pubmed

Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1.

RARS1 LARS1

1.68e-04886236347866
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

DNHD1 RARS1 ABCA13 LRRK2 VPS13A

1.71e-0420886533230847
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

TRIO ANKRD28 PFAS KANK2 DICER1

1.75e-0420986536779422
Pubmed

Proteome analysis of the HIV-1 Gag interactome.

RARS1 LARS1 DICER1

1.80e-044486325010285
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

DNHD1 RARS1 TRIO CLTC LARS1 BYSL PFAS SAMM50 HEATR1 PRKDC TTC3 DICER1

1.98e-041425861230948266
Pubmed

The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers.

RLF UPB1

2.15e-04986225857663
Pubmed

A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.

RARS1 CLTC LARS1 PRKDC

2.16e-0411886427377895
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

CLTC BYSL ANKRD28 PFAS HEATR1 PRKDC BIRC6 DICER1

2.17e-0465386822586326
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

MMS22L RARS1 CLTC VPS13A SAMM50 HEATR1 PRKDC BIRC6

2.26e-0465786836180527
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

PDLIM3 TRIO CLTC ANKRD28 FBXO32 TTC3 BIRC6

2.37e-0449786723414517
Pubmed

The human EPRS locus (formerly the QARS locus): a gene encoding a class I and a class II aminoacyl-tRNA synthetase.

RARS1 LARS1

2.68e-04108628188258
Pubmed

The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex.

RARS1 LARS1

2.68e-041086216055448
Pubmed

The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function.

RARS1 LARS1

2.68e-041086211714285
Pubmed

CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.

CLTCL1 CLTC

2.68e-041086225898166
Pubmed

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization.

LRRK2 PRKDC

2.68e-041086219826009
Pubmed

Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit.

RARS1 LARS1

2.68e-04108628052601
Pubmed

Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme as a case of horizontal gene transfer.

RARS1 LARS1

2.68e-04108628078941
Pubmed

Human lysyl-tRNA synthetase accepts nucleotide 73 variants and rescues Escherichia coli double-defective mutant.

RARS1 LARS1

2.68e-04108629278442
Pubmed

The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.

ACAD11 LARS1 PFAS SAMM50 PRKDC

3.13e-0423786529564676
Pubmed

Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells.

RARS1 LARS1

3.28e-041186219289464
Pubmed

Expression of human aspartyl-tRNA synthetase in Escherichia coli. Functional analysis of the N-terminal putative amphiphilic helix.

RARS1 LARS1

3.28e-04118628449960
Pubmed

Dissection of the structural organization of the aminoacyl-tRNA synthetase complex.

RARS1 LARS1

3.28e-041186219131329
Pubmed

Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.

CLTCL1 CLTC

3.28e-041186229604273
Pubmed

The aftiphilin/p200/gamma-synergin complex.

CLTC HEATR5A

3.28e-041186215758025
Pubmed

STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice.

IRF7 MADCAM1

3.28e-041186232553167
Pubmed

Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development.

RARS1 CLTC LARS1

3.31e-045486331792442
Pubmed

NODs: intracellular proteins involved in inflammation and apoptosis.

NLRP9 NLRP13

3.93e-041286212766759
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ARHGAP4 TDRKH ARHGEF40 ACAD11 ANKRD28 TAF6 TOPORS KANK2 ZKSCAN5 DICER1

4.33e-041116861031753913
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

RARS1 CLTC HEATR1 PRKDC KANK2

4.45e-0425686533397691
Pubmed

Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein.

RARS1 LARS1

4.63e-04138629878398
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

SLC6A6 POLR3B TRIO ARFGAP3 ANKRD28 KANK2 BIRC6 DICER1

4.68e-0473386834672954
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

PDLIM3 GPATCH1 PARG LARS1 ANKRD28 PFAS HEATR1 PRKDC TAF6

5.07e-0493486933916271
Pubmed

EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.

CLTC PRKDC BIRC6

5.21e-046386329162697
Pubmed

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.

MAP1S CLTC VPS13A SAMM50

5.36e-0415086432423001
Pubmed

p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance.

RARS1 LARS1

5.39e-041486212060739
Pubmed

The genetics of NOD-like receptors in Crohn's disease.

NLRP9 NLRP13

5.39e-041486220403135
Pubmed

NALPs: a novel protein family involved in inflammation.

NLRP9 NLRP13

5.39e-041486212563287
Pubmed

Ubiquitin-dependent degradation of CDK2 drives the therapeutic differentiation of AML by targeting PRDX2.

KLHL6 FBXO32

5.39e-041486229720484
Pubmed

A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair.

CLTCL1 RARS1 CLTC PRKDC

5.78e-0415386427462432
Pubmed

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.

CLTC LRRK2

6.21e-041586221307259
Pubmed

RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.

POLR3B RARS1 CLTC LARS1 BYSL PRKDC

6.63e-0442586621081503
Pubmed

Physiological and pathophysiological characteristics of ataxin-3 isoforms.

RARS1 CLTC LARS1 BYSL PRKDC

6.79e-0428186530455355
Pubmed

JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase.

ANKRD28 PRKDC

7.09e-041686226291670
Pubmed

Network organization of the human autophagy system.

ATG10 MAP1S CLTC LARS1 PFAS PRKDC

7.66e-0443786620562859
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF7 PRAMEF8

8.02e-041786223565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF7 PRAMEF8

8.02e-041786237781892
Pubmed

Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.

DNHD1 ARHGEF40

8.02e-041786212693554
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

POLR3B CLTCL1 CLTC LARS1 ANKRD28 IRF7 SAMM50 HEATR1 PRKDC DICER1 TRAPPC9

8.37e-041440861130833792
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

ACAD11 MAP1S ANKRD28 PRKDC BIRC6 TRAPPC9

8.52e-0444686624255178
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF7 PRAMEF8

9.01e-041886223894331
Cytoband19q13.43

ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C NLRP13

6.71e-078786519q13.43
GeneFamilyDyneins, axonemal

DNAH8 DNAH14

1.33e-0317582536
GeneFamilyAminoacyl tRNA synthetases, Class I

RARS1 LARS1

1.67e-0319582131
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

RLF ZSCAN5B ZSCAN5DP ZSCAN5A ZSCAN5C ZNF215 ZKSCAN5 ZNF287

1.97e-0371858828
GeneFamilyPRAME family

PRAMEF7 PRAMEF8

2.67e-0324582686
GeneFamilyNLR family

NLRP9 NLRP13

2.89e-0325582666
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

NLRP9 NLRP13

2.89e-0325582994
GeneFamilyCyclins|F-boxes other

FBH1 FBXO32

6.94e-0339582560
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

THEMIS2 TDRKH GPATCH1 PARG LRRK2 PRKDC

1.59e-06185866daea170d827226dda6750bf1838ffd82f070c4d4
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

USP32 CLTC HEATR5A PRKDC MARVELD2 BIRC6

2.04e-06193866abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCelldroplet-Kidney-nan-3m-Lymphocytic-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL6 TDRKH YDJC DNAH8 ZNF287

8.27e-06142865a88bf4bcc80206b16dcc504cc19a3380d01e34a4
ToppCellTuft-tuft-3|World / Class top

BYSL CCNO LRRIQ4 ZKSCAN5 DKK3

1.01e-05148865f4f59b46a79fc9aa4c5d330a7b37b1a34a6d71cc
ToppCell3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor_pre-Lymphocytic-T|bone_marrow / Manually curated celltypes from each tissue

ABCA13 DYTN ANKRD28 COL6A5 LRRIQ4

2.09e-05172865a66402d15853f0c9e3d06394ff9ac08d1da128ff
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FANCC SLC6A6 CFAP54 ABCA13 LRRK2

2.67e-051818656956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-2|TCGA-Skin / Sample_Type by Project: Shred V9

USP32 CLTC ANKRD28 HEATR5A DYRK3

2.67e-051818659d5b331cabc5524f0a9fd8b571e87be4c447c7d4
ToppCellCOPD-Lymphoid-B_Plasma|Lymphoid / Disease state, Lineage and Cell class

KLHL6 CFAP54 TRIO ANKRD28 ZNF215

2.74e-0518286519db653fe04c5e2957eea1f4893b1c1fca4ddcbd
ToppCellnucseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KLHL6 CFAP54 FBH1 ANKRD28 ZNF215

2.96e-051858653b77bc49cd3740acc025e162a36282ac09e12198
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

MMS22L CLTC HEATR1 PRKDC BIRC6

2.96e-05185865a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FANCC SLC6A6 CFAP54 ABCA13 LRRK2

3.04e-051868655c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

MMS22L CLTC HEATR1 PRKDC BIRC6

3.04e-051868658571956890fc9894d766ba294a28e376b4aba428
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFAP54 TRIO ABCA13 LRRK2 DNAH14

3.20e-0518886563a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDLIM3 FBXO32 KANK2 DKK3 EDNRA

3.28e-051898657ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFAP54 TRIO ABCA13 LRRK2 DNAH14

3.45e-05191865d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDLIM3 FBXO32 KANK2 DKK3 EDNRA

3.45e-0519186508042952431ca1a6fd7dfc13f36eb28643979598
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDLIM3 FBXO32 KANK2 DKK3 EDNRA

3.45e-051918657853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A6 PDLIM3 DKK3 SMAD7 HR

3.45e-051918658691eba35793e4e90f93d50c2145847ee51289f7
ToppCellfacs-Skin-Anagen-3m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A6 UPB1 PDLIM3 DKK3 EDNRA

3.62e-05193865eba3c70701b051bc1ed1f4db9270cb27a77ffc3e
ToppCellfacs-Skin-Anagen-3m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A6 UPB1 PDLIM3 DKK3 EDNRA

3.71e-051948655d30d3d41d5f19cdf3077cc609aa2738762cb8c5
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Epithelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A6 PDLIM3 FBXO32 DKK3 SMAD7

3.81e-05195865f41a68b7c2621594db8d8952e301eeadc96be26f
ToppCellnormal_Lung-Fibroblasts-COL13A1+_matrix_FBs|normal_Lung / Location, Cell class and cell subclass

PDLIM3 COL6A5 KANK2 DKK3 EDNRA

4.00e-051978656c57ab2efb8363828e24211c4d45e58bb73a9a4d
ToppCell(5)_Fibroblasts-(5)_Fibroblast-B_(Myofibroblast)|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

SLC6A6 FBXO32 TTC3 DKK3 HR

4.09e-05198865196257c4420ac801ed9fbb444f11718adb7560ae
ToppCellParenchyma_Control_(B.)-Stromal-TX-Smooth_muscle-2|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

PDLIM3 FBXO32 KANK2 DKK3 EDNRA

4.19e-05199865471738f2059e20407572d9c4cbd11812068333ea
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

THEMIS2 FCGR2B USP32 LRRK2 HEATR5A

4.19e-051998654e0b73d88b1345ec63a9e5629762341e75beb47f
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PDLIM3 COL6A5 KANK2 DKK3 EDNRA

4.19e-05199865e1f1950d6f840485e263b83dc81b98910be3ae7a
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-2|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

PDLIM3 FBXO32 KANK2 DKK3 EDNRA

4.19e-05199865706b7de777ff86eb22e538ccd5c2987ceb6be308
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-2-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PDLIM3 FBXO32 KANK2 DKK3 EDNRA

4.19e-05199865690a4f84b205532c4c9e5c19d5ae430d0655f421
ToppCell18-Airway-Mesenchymal-Mesenchyme_SERPINF1-high|Airway / Age, Tissue, Lineage and Cell class

PDLIM3 TTC3 KANK2 DKK3 EDNRA

4.29e-0520086514ae55660f7412518dcb5cb982f6fe9f23553cfb
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PDLIM3 FBXO32 KANK2 DKK3 EDNRA

4.29e-05200865f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCellControl_saline-Mesenchymal_myocytic|Control_saline / Treatment groups by lineage, cell group, cell type

PDLIM3 FBXO32 KANK2 DKK3 EDNRA

4.29e-052008655ed4261157cd51109b314818133ac3a0d34ee5fa
ToppCellLPS_anti-TNF-Mesenchymal_myocytic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PDLIM3 FBXO32 KANK2 DKK3 EDNRA

4.29e-0520086567dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PDLIM3 COL6A5 KANK2 DKK3 EDNRA

4.29e-05200865cb31cfcfa8e6d6cc610c4c22e97bc009dd8a9e7c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KLHL6 THEMIS2 ARHGAP4 FCGR2C GAB3

4.29e-0520086574ceebee9af63f8b3ec5857eff1b662752bc3862
ToppCellLPS_only-Mesenchymal_myocytic|LPS_only / Treatment groups by lineage, cell group, cell type

PDLIM3 FBXO32 KANK2 DKK3 EDNRA

4.29e-052008658bc9923f82bfb836e2f524204c92050edeae8ca5
ToppCellLPS_IL1RA-Mesenchymal_myocytic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PDLIM3 FBXO32 KANK2 DKK3 EDNRA

4.29e-0520086577631c471cc5d453a749784f838cfa6408caf09b
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ACAD11 ABCA13 LRRK2 ISM2

1.36e-041358648521107817df49efd9a2e81078c8535ed33e729c
ToppCellCerebellum-Macroglia-CSF_related|Cerebellum / BrainAtlas - Mouse McCarroll V32

CFAP54 COL6A5 MADCAM1 DNAH14

1.44e-04137864f004199b654143e9e766e5c5f56858089e98cf5f
ToppCellCerebellum-Macroglia-CSF_related-CHOROID_PLEXUS-Choroid_Plexus.Ttr_(Ttr)--|Cerebellum / BrainAtlas - Mouse McCarroll V32

CFAP54 COL6A5 MADCAM1 DNAH14

1.44e-041378646a5599af9d0ee1be6cac17af09aa4cd50774c683
ToppCellCerebellum-Macroglia-CSF_related-CHOROID_PLEXUS-Choroid_Plexus.Ttr_(Ttr)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

CFAP54 COL6A5 MADCAM1 DNAH14

1.44e-0413786401cbc9082e10ef51a1763a8b2d708eea0434490f
ToppCellCerebellum-Macroglia-CSF_related-CHOROID_PLEXUS-Choroid_Plexus.Ttr_(Ttr)|Cerebellum / BrainAtlas - Mouse McCarroll V32

CFAP54 COL6A5 MADCAM1 DNAH14

1.44e-04137864a22730b6f78b66bb3c46155af37c34e554672dee
ToppCellCerebellum-Macroglia-CSF_related-CHOROID_PLEXUS|Cerebellum / BrainAtlas - Mouse McCarroll V32

CFAP54 COL6A5 MADCAM1 DNAH14

1.44e-04137864ce7c57dad201bd2164fc8b1172aca709f3f7def2
ToppCellControl-Myeloid-Dendritic_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KLHL6 THEMIS2 IRF7 DYRK3

1.70e-04143864bb8d4c335682d1a6798bed0de8bb0603054a4944
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Granulocytic-Neutrophil-Neu_c3-CST7|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

THEMIS2 ARHGEF40 LRRK2 DICER1

1.74e-04144864b638398f559e7fd9d4294d1c830beeb20f905960
ToppCellControl-Myeloid-Dendritic_cells-pDC|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KLHL6 THEMIS2 IRF7 DYRK3

1.79e-04145864bab85a72142b6257f7d424e5301f65b6dcdf745d
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

PDLIM3 LRRIQ4 KANK2 EDNRA

2.61e-04160864fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCellCOVID-19-kidney-Plasma|COVID-19 / Disease (COVID-19 only), tissue and cell type

KLHL6 CFAP54 ANKRD28 ZNF215

2.61e-04160864f8d9e459976e711e9ad39ea2b6173140c0589d6e
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UPB1 FCGR2B COL6A5 IRF7

2.61e-04160864cfd005e98944817458e8ef9e0c436d77f50c1ad1
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma|TCGA-Colorectal / Sample_Type by Project: Shred V9

FCGR2C FCGR2B ARFGAP3 LRRIQ4

2.86e-041648643c15e9b8403b03d67f6ecd7861dc19f1261e3244
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A6 ABCA13 LRRK2 GYG2

2.86e-041648641cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Lymphocytic-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAB3 PRKDC EDNRA DYRK3

2.93e-04165864475905d608fac628960188ae4a18010b8097417e
ToppCell343B-Lymphocytic-ILC|343B / Donor, Lineage, Cell class and subclass (all cells)

KLHL6 ANKRD28 HEATR5A HEATR1

3.00e-04166864a54377c703efff42d2cc1a8fdb610facc58053dd
ToppCellfacs-Skin-Anagen-24m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A6 UPB1 DKK3 EDNRA

3.07e-0416786478909f685ccd1321064eb0887caf9263e0e54879
ToppCellChildren_(3_yrs)-Immune-enucleated_erythrocyte-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

UPB1 FCGR2B ABCA13 SAMM50

3.14e-041688648f0c4dfad9f6fed9dcc31795abfe77758ceb46a1
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(more_DN)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP1S ANKRD28 TRAPPC9 DYRK3

3.14e-04168864b9db0b1e4fe54a1fe79530d15d206155a1bfac39
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 THEMIS2 FCGR2B GAB3

3.21e-04169864b2fdf9f842dc7c181bc951a8a6932c916ed835ef
ToppCelldroplet-Spleen-nan-21m-Myeloid-macrophage_dendritic_cell_progenitor|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UPB1 IRF7 KANK2 HR

3.21e-041698647962165cab84af73d20b56eb70b1ed87c94025ef
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

THEMIS2 FCGR2C FCGR2B ABCA13

3.21e-04169864c100a91be9b94bd433a3b172f4a1bfb9d2393003
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 THEMIS2 FCGR2B GAB3

3.21e-041698642322f03a115c662f808ebfc892192b7d38d48181
ToppCellBasal_cells-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

FBXO32 DKK3 EDNRA HR

3.28e-04170864776d4224a682b6c648041827efd69794f88906f0
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ABCA13 ZSCAN5A DICER1 DYRK3

3.28e-041708640f215911b5880eeffeb43230f7eeaf55b612eaf2
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRRK2 PFAS IRF7 KANK2

3.28e-0417086407b561cd9c528bc8444c9385e1de621eee7b697e
ToppCelldroplet-Pancreas-Endocrine-21m-Hematologic-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL6 ARHGAP4 FCGR2B LRRK2

3.28e-041708646086d658a52a1961a1e293cbc3703ae8d309cd11
ToppCellCOVID-19-kidney-Plasma|kidney / Disease (COVID-19 only), tissue and cell type

KLHL6 THEMIS2 CFAP54 ZNF215

3.36e-04171864a59a054b8e119215f24dc5c80ad5a8094b3500f9
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARHGEF40 MADCAM1 EDNRA ZNF287

3.43e-04172864de4961f4037c439d3e0ec706a257b0ec17f4d5be
ToppCellControl-B_cells-Plasma_cells|Control / group, cell type (main and fine annotations)

KLHL6 CFAP54 ANKRD28 ZNF215

3.66e-04175864fb23858cfce71509cafbe0d9728e678012ff2962
ToppCellfacs-Skin-Anagen-24m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A6 UPB1 DKK3 EDNRA

3.66e-041758645552ff1e13f931c8cd7780726c90b5609497a648
ToppCell356C-Fibroblasts-Fibroblast-G|356C / Donor, Lineage, Cell class and subclass (all cells)

COL6A5 KANK2 DKK3 EDNRA

3.82e-041778648220cc2fc0ee8764a67a3be51d75248be2453040
ToppCellsevere-Myeloid-Neutrophils_1|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SLC6A6 FCGR2B PRKDC TOPORS

3.82e-04177864d1ad35ee3d2a84b1d01126d0a38464ab858c00d0
ToppCell3'-Adult-SmallIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KLHL6 CFAP54 ANKRD28 DYRK3

3.82e-04177864b326376e879afef579b1b7094d756aaff0de270b
ToppCell3'-Adult-SmallIntestine-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KLHL6 CFAP54 ANKRD28 DYRK3

3.82e-04177864393882f1bf7658a17e10a771b803339f16fb2e69
ToppCell356C-Fibroblasts-Fibroblast-G-|356C / Donor, Lineage, Cell class and subclass (all cells)

COL6A5 KANK2 DKK3 EDNRA

3.82e-041778647617270f49cd6b7ba66db72d20560cee985012b2
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FANCC ABCA13 LRRK2 BYSL

3.91e-04178864c20f050344a2e120e685e2a7fe36c6dfc1dc37b6
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid-pDC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KLHL6 THEMIS2 ARHGAP4 IRF7

3.91e-04178864b7d1d8f76c1c2467b1a39a9b4150ed4a47144a15
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDLIM3 FBXO32 KANK2 DKK3

3.99e-0417986402c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|368C / Donor, Lineage, Cell class and subclass (all cells)

THEMIS2 TDRKH GPATCH1 PARG

3.99e-0417986410c7d371937d9d93c12c8d3465430ef9e0c2ec81
ToppCellControl-Stromal-SMC|Control / Disease state, Lineage and Cell class

PDLIM3 KANK2 DKK3 EDNRA

3.99e-041798641378051bc62009eec2dbecf3d5d89baedbeb84eb
ToppCelldroplet-Liver-LIVER_HEP-30m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDLIM3 LRRK2 DKK3 SMAD7

4.07e-04180864dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCelldroplet-Liver-LIVER_HEP|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDLIM3 LRRK2 DKK3 SMAD7

4.07e-04180864423454e3390080ae03bb3cbb267255ebfe4df080
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FANCC CFAP54 ABCA13 LRRK2

4.25e-041828645e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-B_cells-FCRL4+_Memory_B|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THEMIS2 FCGR2B LRRK2 DNAH8

4.43e-0418486495cf125127658c4c04445c61809d1aed21ee1f83
ToppCell343B-Fibroblasts-Fibroblast-E-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

POLR3B ACAD11 GPATCH1 HEATR5A

4.52e-041858641b8e3ddb91797f84e4b15d2457b0c008e5be50db
ToppCell343B-Fibroblasts-Fibroblast-E|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

POLR3B ACAD11 GPATCH1 HEATR5A

4.52e-0418586402cbf492bc40abebaa93a3a208888afae72fbe06
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDLIM3 FBXO32 KANK2 DKK3

4.52e-04185864e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCellwk_08-11-Hematologic-Myeloid-Neutrophil|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

THEMIS2 FCGR2C FCGR2B LRRK2

4.52e-04185864655fb705d7a029844ecb4f6a53e948e37ee81006
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDLIM3 FBXO32 KANK2 DKK3

4.61e-041868646add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-cDC2|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THEMIS2 FCGR2C FCGR2B LRRK2

4.61e-0418686469b107ad88b07e9aeef09d4e4dac99b0cb6b467e
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PDLIM3 COL6A5 DKK3 EDNRA

4.61e-041868645473283fb95cee556b1f6934cf72169b676b5bcc
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ABCA13 LRRK2 ANKRD28 DNAH14

4.61e-04186864acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFAP54 ABCA13 LRRK2 DNAH14

4.61e-04186864f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFAP54 ABCA13 LRRK2 DNAH14

4.70e-04187864c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDLIM3 FBXO32 KANK2 DKK3

4.80e-041888643177b2c1723268d330d3e9f24f9e24492ace6286
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDLIM3 FBXO32 KANK2 DKK3

4.80e-04188864293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCell3'-Adult-LargeIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KLHL6 THEMIS2 FCGR2B ANKRD28

4.80e-041888648e1220066008aef171692c6afffcf31833a3fae8
ToppCell3'-Adult-LargeIntestine-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KLHL6 THEMIS2 FCGR2B ANKRD28

4.80e-0418886431d7e62cce010eed1c2db6d6eb55806d27b26151
ToppCell343B-Lymphocytic-ILC|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

KLHL6 ANKRD28 HEATR5A HEATR1

4.90e-04189864c26428871dc3261327d89cacaba6e21e004ff1f3
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FANCC ABCA13 LRRK2 DNAH14

4.90e-04189864904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDLIM3 FBXO32 KANK2 DKK3

4.90e-0418986445e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A6 CFAP54 ABCA13 LRRK2

4.90e-04189864bd91bdfe35294e60d980259b70fe9e60dca2743f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFAP54 ABCA13 LRRK2 DNAH14

4.99e-041908643fc9e18c7441c0ae8cda65753cc42d0520f4e116
Diseaseplexin-B2 measurement

FCGR2C FCGR2B

2.65e-049812EFO_0021867
Diseasemalaria (implicated_via_orthology)

FCGR2C FCGR2B

2.65e-049812DOID:12365 (implicated_via_orthology)
Diseasehematocrit

FANCC TDRKH FCGR2C ARHGEF40 ACAD11 FCGR2B YDJC PFAS EDNRA SMAD7

4.43e-0410118110EFO_0004348
Diseaselow affinity immunoglobulin gamma Fc region receptor II-a measurement

FCGR2C FCGR2B

9.85e-0417812EFO_0021969
DiseaseAlopecia

EDNRA HR

1.23e-0319812C0002170
Diseaselow affinity immunoglobulin gamma Fc region receptor II-b measurement

FCGR2C FCGR2B

2.14e-0325812EFO_0021970
Diseaseattention deficit hyperactivity disorder (implicated_via_orthology)

FBXO32 TRAPPC9

2.69e-0328812DOID:1094 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
WLPALHLFDVALKLC

CFAP54

2581

Q96N23
LPWAELICPRFVHKE

ARHGEF40

176

Q8TER5
RKHGTDLWLDSCVVP

ARFGAP3

126

Q9NP61
AWCDLTIHLPAAVLL

BIRC6

3206

Q9NR09
ESRCKLLSWLIPVHR

CCNO

131

P22674
ETIVLRCHSWKDKPL

FCGR2B

146

P31994
DSKWLTPLHRAVASC

ANKRD28

71

O15084
VDPCSRHSLWDILLK

ABCA13

4006

Q86UQ4
ALCWFPLHLSRILKK

EDNRA

316

P25101
RPLTLKDIWEGVHEC

ATG10

121

Q9H0Y0
HPDLPKWLASLEKCL

DNHD1

1441

Q96M86
ELCAIHPIPASLWRK

DICER1

1036

Q9UPY3
HPKECRVIAVLDWEL

ACAD11

231

Q709F0
SWVRHKPSERLCLLP

KLHL6

241

Q8WZ60
LWKRCRHLAEDDTHP

MADCAM1

341

Q13477
ERTLASVCALLVWHP

MAP1S

406

Q66K74
KVPRLICRWTSLHLL

LRRIQ4

271

A6NIV6
LCIKELWVLLIHLLD

MMS22L

291

Q6ZRQ5
PIRVIDLSECAVWKH

GAB3

56

Q8WWW8
PVLACSGLDHDVKIW

DCAF8L2

526

P0C7V8
WHCPFLLETKILERA

HR

141

O43593
LTRDTFEWHPDKLLC

GPATCH1

606

Q9BRR8
ETIVLRCHSWKDKPL

FCGR2C

146

P31995
ILCKGDWSRLHAVLP

ISM2

531

Q6H9L7
PEWERCEKPLTRLHV

PARG

706

Q86W56
LDTCHKLLLIRSWCP

DNAH8

3856

Q96JB1
LDCVSHTPALRLWIS

GSTO2

191

Q9H4Y5
CLALVHLPVEKESWI

LRRK2

2201

Q5S007
VKLEPWLCRVHLEGT

IRF7

451

Q92985
PELGLTLTKLHCWTL

GYG2

111

O15488
LSLVCHLWREIISDP

FBH1

236

Q8NFZ0
APHLPWLCVEKLDLL

FER1L6-AS2

81

Q96M78
HLARVLLLWKCVFPA

HEATR5A

571

Q86XA9
ILLWLPTCHRLSAAE

DYTN

206

A2CJ06
WKSLEECLEKHLPLP

UPB1

6

Q9UBR1
DLIRFLREHSPCWKE

COL6A5

1736

A8TX70
CLWLRHLPSLEKAML

FANCC

241

Q00597
PLTDRCWLTLMEALH

DNAH14

1141

Q0VDD8
PRTLDEVLKWAHCLT

GPR142

306

Q7Z601
LISALVCLKLWRHEA

MARVELD2

356

Q8N4S9
SCWLVKRSHVELLLG

ITIH6

1291

Q6UXX5
EWLRLACRSDAHPEL

KANK2

626

Q63ZY3
CSLHPLLRGWEEALE

HEATR1

631

Q9H583
LHVLSEDRLLWKKLC

FBXO32

256

Q969P5
RTLDECLTHLLEWGK

PRAMEF8

156

Q5VWM4
PKAHIRKLAECIRWS

SAMM50

411

Q9Y512
CHDPASRLLDLITWE

DKK3

241

Q9UBP4
KRELPVLWHQCLLTL

BYSL

371

Q13895
IEFLKRCLHWDPSAR

DYRK3

496

O43781
LDHEKEWKLGRCILR

RARS1

566

P54136
PLDVCLKAHWLSIEG

TAF6

126

P49848
DHPGSLKWDLALCLL

SLC6A6

211

P31641
LCEHIWTLLGKPDSI

LARS1

866

Q9P2J5
LCLKIDRGETHLWSP

PDLIM3

76

Q53GG5
SRLCLEPREHAWILA

SOWAHD

106

A6NJG2
RKEPSLLSPLHCWAV

ARHGAP4

91

P98171
KLLLPWLEARIHEGC

CLTC

856

Q00610
YLVCRKDPELWAHVL

CLTCL1

946

P53675
AALKHPGCSIRELWL

NLRP9

821

Q7RTR0
AKRCWHSLLSVPKIL

TP53TG5

66

Q9Y2B4
RTLDECLTHLLEWGK

PRAMEF7

156

Q5VXH5
PWTKLKTHPICLSLD

UHRF1BP1L

71

A0JNW5
PLLLCKVFRWPDLRH

SMAD7

156

O15105
KLTELCHLWLRPDLH

ZSCAN5DP

61

P0CG00
WVPCLHDETEKLVRK

VPS13A

191

Q96RL7
RELCLKWLRPEIHSK

ZNF287

71

Q9HBT7
RLTHCADWKPLVAKI

TDRKH

441

Q9Y2W6
LRCELLLALKAHWPF

RLF

451

Q13129
CPLLLDDVARESWLL

PFAS

66

O15067
ALRKLTELCHLWLRP

ZSCAN5B

61

A6NJL1
TELCHLWLRPDLHTK

ZSCAN5B

66

A6NJL1
ALKDLVLTCPTLPWH

THEMIS2

186

Q5TEJ8
ALRKLTELCHLWLRP

ZSCAN5A

61

Q9BUG6
TELCHLWLRPDLHTK

ZSCAN5A

66

Q9BUG6
SEPASLKEARCLIWL

TTC3

961

P53804
LKEARCLIWLLEEHR

TTC3

966

P53804
CLIWLLEEHRDKFPA

TTC3

971

P53804
CSWERLHELRVLTAP

YDJC

266

A8MPS7
TVKPCLDLLVNWLHI

RRN3P1

46

Q2M238
KPIWRHEILDADGIC

POLR3B

801

Q9NW08
ASLCLLDLVKWLLAH

PRKDC

1161

P78527
LPLKICLHLGWDEGL

nan

16

Q86TA4
RRLKLAHFCPDTSLW

nan

411

Q3C1V9
WDSIHEKICQLLIPL

ZMYND12

46

Q9H0C1
ACLHRLVPWLKRELT

TOPORS

291

Q9NS56
ELCLQWLRPEIHTKK

ZNF215

71

Q9UL58
LEIHSKLGICWRIPS

TRAPPC9

976

Q96Q05
ALRKLTELCHLWLRP

ZSCAN5C

61

A6NGD5
TELCHLWLRPDLHTK

ZSCAN5C

66

A6NGD5
THCLATKKLDLWRLP

USP32

1261

Q8NFA0
LERPHDKPDWCLVRT

TRIO

1686

O75962
LRVLCCEWLRPELHT

ZKSCAN5

71

Q9Y2L8
CEWLRPELHTKEQIL

ZKSCAN5

76

Q9Y2L8
ALTHPKCALERLELW

NLRP13

861

Q86W25
SRFSILIEAWEHCKP

NAALADL2

741

Q58DX5