Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	SMARCA2 PPARGC1A PPARGC1B URI1 DUSP19 EZH2 TAF11 STX1B AXIN1	6.07e-05	1160	32	9	GO:0030674
GeneOntologyMolecularFunction	molecular adaptor activity	SMARCA2 PPARGC1A PPARGC1B URI1 DUSP19 EZH2 TAF11 STX1B AXIN1	2.01e-04	1356	32	9	GO:0060090
GeneOntologyMolecularFunction	transcription coregulator activity	SMARCA2 PPARGC1A PPARGC1B URI1 EZH2 TAF11	2.35e-04	562	32	6	GO:0003712
GeneOntologyMolecularFunction	transcription coactivator activity	SMARCA2 PPARGC1A PPARGC1B TAF11	1.34e-03	303	32	4	GO:0003713
GeneOntologyMolecularFunction	lncRNA binding	PPARGC1A EZH2	1.43e-03	35	32	2	GO:0106222
GeneOntologyCellularComponent	meiotic cohesin complex	SMC1A SMC1B	4.74e-05	7	32	2	GO:0030893
GeneOntologyCellularComponent	cohesin complex	SMC1A SMC1B	1.24e-04	11	32	2	GO:0008278
GeneOntologyCellularComponent	nuclear lamina	LMNB1 STX1B	3.04e-04	17	32	2	GO:0005652
GeneOntologyCellularComponent	lateral element	SMC1A SMC1B	3.82e-04	19	32	2	GO:0000800
GeneOntologyCellularComponent	chromosome, centromeric region	EZH2 SPOUT1 SMC1A SMC1B	7.99e-04	276	32	4	GO:0000775
GeneOntologyCellularComponent	M band	KLHL41 MYBPC3	1.03e-03	31	32	2	GO:0031430
GeneOntologyCellularComponent	nuclear periphery	LMNB1 STX1B SMC1A	2.24e-03	171	32	3	GO:0034399
GeneOntologyCellularComponent	synaptonemal complex	SMC1A SMC1B	2.25e-03	46	32	2	GO:0000795
GeneOntologyCellularComponent	synaptonemal structure	SMC1A SMC1B	2.25e-03	46	32	2	GO:0099086
GeneOntologyCellularComponent	A band	KLHL41 MYBPC3	2.87e-03	52	32	2	GO:0031672
Domain	SMC	SMC1A SMC1B	3.02e-05	5	33	2	IPR024704
Domain	SMC_hinge	SMC1A SMC1B	4.52e-05	6	33	2	IPR010935
Domain	SMC_hinge	SMC1A SMC1B	4.52e-05	6	33	2	PF06470
Domain	SMC_hinge	SMC1A SMC1B	4.52e-05	6	33	2	SM00968
Domain	RecF/RecN/SMC_N	SMC1A SMC1B	8.42e-05	8	33	2	IPR003395
Domain	SMC_N	SMC1A SMC1B	8.42e-05	8	33	2	PF02463
Domain	-	SMARCA2 RAB18 GTPBP3 SMC1A SMC1B	9.41e-03	746	33	5	3.40.50.300
Pathway	REACTOME_MEIOSIS	TEX15 LMNB1 SMC1A SMC1B	5.50e-05	120	25	4	M529
Pathway	REACTOME_REPRODUCTION	TEX15 LMNB1 SMC1A SMC1B	1.60e-04	158	25	4	M26956
Pathway	REACTOME_MEIOTIC_SYNAPSIS	LMNB1 SMC1A SMC1B	3.43e-04	78	25	3	M1061
Pathway	WP_MITOCHONDRIAL_GENE_EXPRESSION	PPARGC1A PPARGC1B	5.07e-04	19	25	2	M39544
Pathway	WP_MITOCHONDRIAL_GENE_EXPRESSION	PPARGC1A PPARGC1B	5.07e-04	19	25	2	MM15973
Pubmed	Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor γ coactivator-1α.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	22087241
Pubmed	SMC1α Substitutes for Many Meiotic Functions of SMC1β but Cannot Protect Telomeres from Damage.	SMC1A SMC1B	8.73e-07	2	33	2	29337080
Pubmed	The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	26427438
Pubmed	Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	17018837
Pubmed	Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	31101737
Pubmed	Fasting-Induced Transcription Factors Repress Vitamin D Bioactivation, a Mechanism for Vitamin D Deficiency in Diabetes.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	30833469
Pubmed	Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	16679291
Pubmed	A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	26950361
Pubmed	Promoter methylation of PGC1A and PGC1B predicts cancer incidence in a veteran cohort.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	29888964
Pubmed	Peroxisome proliferator-activated receptor γ coactivator family members competitively regulate hepatitis b virus biosynthesis.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	30419515
Pubmed	The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defence in skeletal muscles.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	26674215
Pubmed	Calorie restriction prevents diet-induced insulin resistance independently of PGC-1-driven mitochondrial biogenesis in white adipose tissue.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	30277821
Pubmed	Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	16132959
Pubmed	Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	17141629
Pubmed	Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	16896940
Pubmed	Alternative splice variant PGC-1α-b is strongly induced by exercise in human skeletal muscle.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	21862727
Pubmed	No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	12032643
Pubmed	Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	23707060
Pubmed	Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	19906680
Pubmed	PGC-1 proteins and heart failure.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	22939990
Pubmed	PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	35131872
Pubmed	Adult expression of PGC-1α and -1β in skeletal muscle is not required for endurance exercise-induced enhancement of exercise capacity.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	27780821
Pubmed	PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors.	SMARCA2 EZH2	8.73e-07	2	33	2	29087303
Pubmed	PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	19297390
Pubmed	Analysis of Metabolic Regulators PGC1-α and PGC1-β in Oral Squamous Cell Carcinoma with and without Hyperglycemia.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	36037136
Pubmed	The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	26159922
Pubmed	A role for peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) in the regulation of cardiac mitochondrial phospholipid biosynthesis.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	24337569
Pubmed	A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	12107756
Pubmed	Estrogen Signals Through Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease.	PPARGC1A PPARGC1B	8.73e-07	2	33	2	27658772
Pubmed	Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development.	PPARGC1A PPARGC1B LMNB1	1.55e-06	24	33	3	25348719
Pubmed	Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models.	SMARCA2 EZH2	2.62e-06	3	33	2	28292935
Pubmed	Novel meiosis-specific isoform of mammalian SMC1.	SMC1A SMC1B	2.62e-06	3	33	2	11564881
Pubmed	GADD45γ regulates the thermogenic capacity of brown adipose tissue.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	25071184
Pubmed	Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	16704985
Pubmed	Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	21109195
Pubmed	Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	11793024
Pubmed	New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	25495651
Pubmed	PI3K/AKT phosphorylation activates ERRα by upregulating PGC‑1α and PGC‑1β in gallbladder cancer.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	34184087
Pubmed	Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	28158196
Pubmed	The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	11854298
Pubmed	Transcriptional control of brown fat determination by PRDM16.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	17618855
Pubmed	PGC-1 coactivator activity is required for murine erythropoiesis.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	24662048
Pubmed	PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	12470660
Pubmed	Assessment of PPARGC1A, PPARGC1B, and PON1 Genetic Polymorphisms in Esophageal Squamous Cell Carcinoma Susceptibility in the Eastern Chinese Han Population: A Case-Control Study Involving 2351 Subjects.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	32721231
Pubmed	A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	10713165
Pubmed	ERRγ Promotes Angiogenesis, Mitochondrial Biogenesis, and Oxidative Remodeling in PGC1α/β-Deficient Muscle.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	29514081
Pubmed	[Study of the 482G/A variation in PGC-1alpha gene domain MEF2C as possible mechanism of type 2 diabetes].	PPARGC1A PPARGC1B	2.62e-06	3	33	2	19065516
Pubmed	Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	12832613
Pubmed	The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	22080103
Pubmed	The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	23223635
Pubmed	Downregulation of peroxisome proliferator-activated receptor alpha and its coactivators in liver and skeletal muscle mediates the metabolic adaptations during lactation in mice.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	19578095
Pubmed	Hepatic PGC-1beta overexpression induces combined hyperlipidemia and modulates the response to PPARalpha activation.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	17932310
Pubmed	A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	24366168
Pubmed	Association between PPARγ, PPARGC1A, and PPARGC1B genetic variants and susceptibility of gastric cancer in an Eastern Chinese population.	PPARGC1A PPARGC1B	2.62e-06	3	33	2	36587194
Pubmed	Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.	PPARGC1A PPARGC1B	5.23e-06	4	33	2	17554339
Pubmed	PGC-1 coactivators regulate MITF and the tanning response.	PPARGC1A PPARGC1B	5.23e-06	4	33	2	23201126
Pubmed	Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy.	PPARGC1A PPARGC1B	5.23e-06	4	33	2	20404331
Pubmed	Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.	PPARGC1A PPARGC1B	5.23e-06	4	33	2	15680331
Pubmed	The genetics of human infertility by functional interrogation of SNPs in mice.	TEX15 SMC1B	5.23e-06	4	33	2	26240362
Pubmed	Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha.	PPARGC1A PPARGC1B	5.23e-06	4	33	2	12181319
Pubmed	PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin.	PPARGC1A PPARGC1B	5.23e-06	4	33	2	30770439
Pubmed	Distinct Roles of Meiosis-Specific Cohesin Complexes in Mammalian Spermatogenesis.	SMC1A SMC1B	5.23e-06	4	33	2	27792785
Pubmed	Identification and molecular characterization of the mammalian α-kleisin RAD21L.	SMC1A SMC1B	8.72e-06	5	33	2	21527826
Pubmed	The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1.	PPARGC1A HUWE1	8.72e-06	5	33	2	28148912
Pubmed	Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.	PPARGC1A PPARGC1B	8.72e-06	5	33	2	18483224
Pubmed	PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2.	PPARGC1A PPARGC1B	8.72e-06	5	33	2	33712605
Pubmed	Cohesins localize with CTCF at the KSHV latency control region and at cellular c-myc and H19/Igf2 insulators.	SMC1A SMC1B	8.72e-06	5	33	2	18219272
Pubmed	Regulation of gene expression by FSP27 in white and brown adipose tissue.	PPARGC1A PPARGC1B	8.72e-06	5	33	2	20649970
Pubmed	Peroxisomal localization and circadian regulation of ubiquitin-specific protease 2.	PPARGC1A PPARGC1B	8.72e-06	5	33	2	23133608
Pubmed	Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis.	SMC1A SMC1B	8.72e-06	5	33	2	12759374
Pubmed	Differential regulation of the PGC family of genes in a mouse model of Staphylococcus aureus sepsis.	PPARGC1A PPARGC1B	8.72e-06	5	33	2	20657826
Pubmed	HiPLA: High-throughput imaging proximity ligation assay.	LMNB1 EZH2 SMC1A	1.15e-05	46	33	3	30419336
Pubmed	Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex.	PPARGC1A PPARGC1B	1.31e-05	6	33	2	17050673
Pubmed	Chromosomal domains and escape from X inactivation: comparative X inactivation analysis in mouse and human.	HUWE1 SMC1A	1.31e-05	6	33	2	11003698
Pubmed	Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance.	PPARGC1A PPARGC1B	1.31e-05	6	33	2	12565902
Pubmed	Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells.	PPARGC1A PPARGC1B	1.31e-05	6	33	2	23836911
Pubmed	Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.	PPARGC1A PPARGC1B	1.31e-05	6	33	2	11733490
Pubmed	A role for protein inhibitor of activated STAT1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptors.	PPARGC1A PPARGC1B	1.83e-05	7	33	2	22969086
Pubmed	FBXL10 promotes ERRα protein stability and proliferation of breast cancer cells by enhancing the mono-ubiquitylation of ERRα.	PPARGC1A PPARGC1B	1.83e-05	7	33	2	33450359
Pubmed	New insights into BS69 functions.	SMARCA2 EZH2	2.44e-05	8	33	2	16565076
Pubmed	Single-nucleotide polymorphisms within the antioxidant defence system and associations with aggressive prostate cancer.	PPARGC1A PPARGC1B	2.44e-05	8	33	2	20477822
Pubmed	Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice.	PPARGC1A PPARGC1B	3.13e-05	9	33	2	34029594
Pubmed	Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression.	PPARGC1A PPARGC1B	3.13e-05	9	33	2	10585775
Pubmed	Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation.	LMNB1 AXIN1	3.13e-05	9	33	2	26912724
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	RAB18 UTP18 HUWE1 LMNB1 SPOUT1 SMC1A SYMPK	3.29e-05	989	33	7	36424410
Pubmed	RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis.	SMC1A SMC1B	3.91e-05	10	33	2	21242291
Pubmed	Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages.	HUWE1 EZH2	3.91e-05	10	33	2	36635505
Pubmed	The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes.	PPARGC1A PPARGC1B	3.91e-05	10	33	2	19653005
Pubmed	Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease.	PPARGC1A PPARGC1B	4.78e-05	11	33	2	36693621
Pubmed	A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell.	EZH2 SMC1A	4.78e-05	11	33	2	18385154
Pubmed	Involvement of heparan sulfate 6-O-sulfation in the regulation of energy metabolism and the alteration of thyroid hormone levels in male mice.	PPARGC1A PPARGC1B	4.78e-05	11	33	2	23690091
Pubmed	The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart.	SMARCA2 EZH2	4.78e-05	11	33	2	24137001
Pubmed	Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics.	SMARCA2 EZH2	4.78e-05	11	33	2	22439931
Pubmed	A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis.	PPARGC1A PPARGC1B	5.73e-05	12	33	2	21966468
Pubmed	p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes.	LMNB1 EZH2	5.73e-05	12	33	2	28595999
Pubmed	A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing.	SMC1A SMC1B	5.73e-05	12	33	2	21274006
Pubmed	Inactivation of Type 3 Deiodinase Results in Life-long Changes in the Brown Adipose Tissue Transcriptome in the Male Mouse.	PPARGC1A PPARGC1B	5.73e-05	12	33	2	35238380
Pubmed	Loss-of-Function Variants in TBC1D32 Underlie Syndromic Hypopituitarism.	RAB18 URI1 SPOUT1	6.31e-05	81	33	3	32060556
Pubmed	Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis.	SMC1A SMC1B	6.77e-05	13	33	2	29754823
Pubmed	Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues.	PPARGC1A PPARGC1B	6.77e-05	13	33	2	33888560
Cytoband	Ensembl 112 genes in cytogenetic band chr2p24	RAD51AP2 TDRD15	1.57e-03	81	33	2	chr2p24
Cytoband	Ensembl 112 genes in cytogenetic band chr9p24	SMARCA2 DOCK8	2.61e-03	105	33	2	chr9p24
GeneFamily	Structural maintenance of chromosomes proteins\|Cohesin complex	SMC1A SMC1B	2.43e-05	7	20	2	761
GeneFamily	Cohesin complex	SMC1A SMC1B	3.24e-05	8	20	2	1060
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KLHL41 ZBTB14	9.49e-03	134	20	2	861
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	URI1 AXIN1	1.68e-02	181	20	2	694
GeneFamily	RNA binding motif containing	PPARGC1A PPARGC1B	2.28e-02	213	20	2	725
Coexpression	PUJANA_BRCA_CENTERED_NETWORK	LMNB1 EZH2 TAF11 SMC1A	1.44e-05	118	33	4	M15305
ToppCell	facs-Heart-LV-3m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TACO1 PPARGC1B KLHL41 MYBPC3	1.10e-05	188	33	4	ba7f7ce034c0f42742bf2461f68f8d343ee593a5
ToppCell	facs-Heart-LV-3m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TACO1 PPARGC1B KLHL41 MYBPC3	1.10e-05	188	33	4	40ce7125fca6f6b6b5cc1637c87d43c29b08f4f1
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	COG5 SMC1B MYBPC3	1.50e-04	140	33	3	276b3fa924176426efb31112ed4d355407f0b218
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PPARGC1A KLHL41 MYBPC3	2.52e-04	167	33	3	91b14df450bfb6a2b406c88f8c75cd51eeb9e82b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TEX15 LMNB1 EZH2	2.61e-04	169	33	3	121768fc51fc3441ec725346a1bbe29e21d05971
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TEX15 LMNB1 EZH2	2.61e-04	169	33	3	0bc8ef341ce307b19018d4ac8de0a4d04254209d
ToppCell	10x5'-Lung-Lymphocytic_T_CD4/8-lo-Cycling_T\|Lung / Manually curated celltypes from each tissue	LMNB1 EZH2 SMC1B	2.71e-04	171	33	3	976361f67dd725870e0513ae7a92f2dcaee17148
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LMNB1 EZH2 COG5	2.75e-04	172	33	3	2b6cd84c946b1e800caba452ae70145ea285fec1
ToppCell	367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	LMNB1 EZH2 SMC1B	2.75e-04	172	33	3	8d20eda599abf1e9e3e3b90f314acddee6a465a4
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	2.75e-04	172	33	3	bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	2.75e-04	172	33	3	ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCell	BAL-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	LMNB1 EZH2 SMC1B	2.90e-04	175	33	3	553e68e8b439a2293efb969e1e2aa017ceb80daf
ToppCell	BAL-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	LMNB1 EZH2 SMC1B	2.90e-04	175	33	3	16d4e97271df1db9a0d167fc82a90d84d20dd1f2
ToppCell	BAL-Control-Lymphocyte-T/NK-Other_T\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	LMNB1 EZH2 SMC1B	2.90e-04	175	33	3	289d2aa7164bc02b1876b99f2fb67baa8e030c4e
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TMEM67 KLHL41 MYBPC3	2.95e-04	176	33	3	4ed73c73972334f6dc4229920205547823252fa0
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TEX15 LMNB1 EZH2	2.99e-04	177	33	3	f925a15d2162d166a5b60edac3517c6b2d6cfbea
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_prolif-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TCIRG1 PITPNC1 SMC1B	3.04e-04	178	33	3	30d2b54462fd16222ad2e3806be6143e834b29e0
ToppCell	droplet-Spleen-nan-3m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEX15 LMNB1 EZH2	3.09e-04	179	33	3	54621d2b3a66e62aa76b7e444118878ed97c1e02
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DUSP19 EZH2 SMC1B	3.15e-04	180	33	3	0c146e80d55d18b6988dd21b1da635801bd3140c
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DUSP19 EZH2 SMC1B	3.15e-04	180	33	3	e9af22beae2f3c7fe213b4e19df84abfd2453433
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DUSP19 EZH2 SMC1B	3.15e-04	180	33	3	11455ba704ac73f69b474845136cfecec6a88349
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 TEX15	3.30e-04	183	33	3	03c7e69136d5a3b9c5b2c91733e9b1c791f45c49
ToppCell	Control-T/NK-proliferating_T/NK\|Control / Disease group,lineage and cell class （2021.01.30）	LMNB1 EZH2 SMC1B	3.30e-04	183	33	3	e740f05536d1e4b2512811771928eb65f6696409
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating-T_cells_proliferating_L.1.1.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LMNB1 EZH2 SMC1A	3.35e-04	184	33	3	eaef1dcde60ba14e2c7fd699d01c225487256d82
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LMNB1 EZH2 STX1B	3.35e-04	184	33	3	d1e0e3b0eed2db8a5b7e3d6f81294667e4ba64e5
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LMNB1 EZH2 SMC1A	3.35e-04	184	33	3	fa73738350654066d7f9ebf78359e20ee6cbdd98
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LMNB1 EZH2 SMC1A	3.35e-04	184	33	3	bba0138c8f7e3645a688b9a4d12f6f2134ee2c08
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PITPNC1 LMNB1 EZH2	3.46e-04	186	33	3	75b1f342be5d6dbe0e7acd924a0ca75964f6bab0
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PITPNC1 LMNB1 EZH2	3.46e-04	186	33	3	0c3d195077de7b4c354c127a26116438aef29244
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PITPNC1 LMNB1 EZH2	3.46e-04	186	33	3	a558fd00053e7dd6216b01dc8e650c30cee451f1
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.46e-04	186	33	3	337f768cc43db2db96ba6495b076006b1a5b0331
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.46e-04	186	33	3	e378c82ef6d6cb24751515aa499a01372b3e7ccf
ToppCell	facs-Heart-Unknown-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.52e-04	187	33	3	0ffb988e0da2c7205c3515eca8e9851739bff5c5
ToppCell	facs-Heart-Unknown\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.52e-04	187	33	3	362e56426a568423a81e8a30e3ecf99b76135843
ToppCell	facs-Heart-Unknown-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.52e-04	187	33	3	c004567767b89f3d89f5c7b28d952f3445957e1e
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.57e-04	188	33	3	90dc0e15798d0b984518ad58c7e416e30aff687a
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.57e-04	188	33	3	f63dfd076ced81013918363282ae25cbbd8948ae
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.57e-04	188	33	3	0554d542149cef654ff1e5e32dfbffd8990b52bd
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.57e-04	188	33	3	4db566f3f708e66730aa9e16f4d73d91dc534177
ToppCell	COPD-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	PITPNC1 LMNB1 AXIN1	3.57e-04	188	33	3	186fe1ea328c942910190a4240262c0d8642ea3b
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.57e-04	188	33	3	6704b92991ad8c0a910e9f36cd33d00bd26dcb8f
ToppCell	facs-Heart-RA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.63e-04	189	33	3	b98f60875b1a12b2ec9dc91889298ae57f98602f
ToppCell	facs-Heart-RA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.63e-04	189	33	3	e758b264c0a47127e33e66c395cf5a3224c7305b
ToppCell	facs-Heart-LA/RA\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.63e-04	189	33	3	efa913d9c16fc32166b484d92b6449e8a0c59e03
ToppCell	facs-Heart-LA/RA-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.63e-04	189	33	3	a08b2d0fa35ffa510050ecffdc68e1b79bbe1632
ToppCell	facs-Heart-LV-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.74e-04	191	33	3	9d7d680da3979e256191b534ebd14c5383e0cf93
ToppCell	facs-Heart-LV-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.74e-04	191	33	3	543da1197c7e62f2c9cbd4a51414bbaaa6d1a92f
ToppCell	droplet-Heart-nan-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.74e-04	191	33	3	97fb4232417a39801e87725755fd16a57c250209
ToppCell	droplet-Heart-nan-3m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.74e-04	191	33	3	64070a309d7e3f6001272409ab9ce206d0e7d73f
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.74e-04	191	33	3	715f5b449b8e075959c05a5b38389df319663164
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.74e-04	191	33	3	c172c9e17b893b290e4aa8af5e5e4cd3e4818372
ToppCell	droplet-Lung-30m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l12-14\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LMNB1 EZH2 SMC1A	3.80e-04	192	33	3	52d0aa51e3b6ab3608a5f40bdde9f8134b3afd94
ToppCell	droplet-Heart-nan-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.80e-04	192	33	3	1a0c25106ae08eac912a4edd5fc1a3ee776f69c2
ToppCell	droplet-Heart-nan-18m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.80e-04	192	33	3	0bf99e029a06151092db1e8a0dcb45f4e688e771
ToppCell	droplet-Heart-nan-24m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.80e-04	192	33	3	f6a4e348406a852ace9fb21db8fbdff539217645
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMARCA2 PITPNC1 LMNB1	3.80e-04	192	33	3	c8dcd75d695d09adff083af8d5a64cf15fe027d4
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMARCA2 PITPNC1 LMNB1	3.80e-04	192	33	3	a502e95f78f96ed060654a769c6a0cc5dc5fcfd9
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMARCA2 PITPNC1 LMNB1	3.80e-04	192	33	3	1a3f24607cb49aa610c183f4c2b7d735f484a3a4
ToppCell	droplet-Heart-nan-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	3.80e-04	192	33	3	d766221acfce30cbf2c60b3ae40f6744968b952c
ToppCell	E18.5-Endothelial\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMARCA2 PITPNC1 LMNB1	3.80e-04	192	33	3	cb55d30880237ab8dccf7f7bd31eb7dc5aba0583
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LMNB1 EZH2 SMC1B	3.92e-04	194	33	3	6cc689595a182fbf685fa2f3b9c300f7170fb81f
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMARCA2 PITPNC1 EZH2	3.92e-04	194	33	3	ae6d5cf4c825b29e677296df2c0985431c83b82e
ToppCell	(4)_B_Hypermutation\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	LMNB1 EZH2 SMC1B	3.97e-04	195	33	3	54d2acaff6be6b5604591bdbd7d769ac3e74f223
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	4.03e-04	196	33	3	fba52a4b82086dbae9a55038bf44c4539be926f5
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LMNB1 EZH2 SMC1B	4.03e-04	196	33	3	76f581e35967f8f7c85a8556129f6e8042ad11ca
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LMNB1 DOCK8 RUBCNL	4.03e-04	196	33	3	fe8d3f45a64323947c36b127355d5940eb56c0ca
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LMNB1 DOCK8 RUBCNL	4.03e-04	196	33	3	526d037bb12d81f1c235c60ddc787fbad0bbad77
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KLHL41 MYBPC3	4.03e-04	196	33	3	a582130862bee76c0385156a333bfdfc75cf218b
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	AMDHD1 TDRD15 DOCK8	4.09e-04	197	33	3	c6645db1bfb5a352cfbb8d83fd1929dcfd41e216
ToppCell	wk_15-18-Hematologic_Lymphocytic-B-Large_pre-B\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	LMNB1 EZH2 RUBCNL	4.09e-04	197	33	3	7e0834b3947031bf244a10624dcf3f2095c79368
ToppCell	distal-Hematologic-Proliferating_NK/T-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LMNB1 EZH2 SMC1B	4.09e-04	197	33	3	04b10879e48c101d1de449db0bc6b6484090b965
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LMNB1 DOCK8 RUBCNL	4.09e-04	197	33	3	3cd1c816bc7a57278b2ef615b69545356ab8f522
ToppCell	wk_20-22\|World / Celltypes from embryonic and fetal-stage human lung	TCIRG1 DOCK8 RUBCNL	4.16e-04	198	33	3	56eb765773a1a27a44262a447df7cfae8a9db90d
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4_TRM/EMRA\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PITPNC1 EZH2 DOCK8	4.16e-04	198	33	3	cf2057fc7c41d509ff76c0f1916e801a2a8406b2
ToppCell	Immune_cells-large_pre-B.\|Immune_cells / Lineage and Cell class	LMNB1 EZH2 SMC1A	4.16e-04	198	33	3	bc9ceefadb153907d2854d1f736d17349003cb31
ToppCell	distal-2-Hematologic-Proliferating_NK/T\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LMNB1 EZH2 SMC1B	4.16e-04	198	33	3	a5fd710df5669c95fc5b5ef6e5cfafe6687c7b72
ToppCell	(0)_NK_Dividing\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	LMNB1 EZH2 SMC1B	4.16e-04	198	33	3	5ebb4965b723302152b42bfaf48bb77a57dd02c5
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic-granulocyte\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LMNB1 EZH2 SMC1A	4.16e-04	198	33	3	2e669da80363163b806f23a645474d482797ae5d
ToppCell	B_cell_maturation-pre-B\|B_cell_maturation / Lineage and Cell class	LMNB1 EZH2 SMC1A	4.22e-04	199	33	3	4bf6a656de04d92103cbe743cd07afd9d125c654
ToppCell	distal-Hematologic-Proliferating_NK/T\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LMNB1 EZH2 SMC1B	4.22e-04	199	33	3	4f02e03c118744fba0dfc5e3ed6dea4041f3d089
ToppCell	Biopsy_Control_(H.)-Epithelial-Proliferating_Epithelial_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	LMNB1 EZH2 SMC1B	4.22e-04	199	33	3	4fcf5bec207e4384fd73c5e8801a7e414e3ee7b0
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma\|TCGA-Bladder / Sample_Type by Project: Shred V9	GTPBP3 LMNB1 EZH2	4.22e-04	199	33	3	8ee3dbc0a92de5f3865e5484970ae2aab7d1a956
ToppCell	TCGA-Bladder-Primary_Tumor\|TCGA-Bladder / Sample_Type by Project: Shred V9	GTPBP3 LMNB1 EZH2	4.22e-04	199	33	3	c403e28def2e14f5931cd73b4fb9a4078c0439f8
ToppCell	10x5'v1-week_17-19-Lymphocytic_B-B_lineage-pre_B_progenitor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LMNB1 EZH2 RUBCNL	4.22e-04	199	33	3	be425e9cb90a73289026b1b7cb581e1c02a8985e
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature-cycling_ENCC/glia\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LMNB1 EZH2 RUBCNL	4.22e-04	199	33	3	9940f347973bf976ee23fb4b1cf1f349d96c21df
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	TCIRG1 DOCK8 RUBCNL	4.28e-04	200	33	3	0eccf41edefc3b8b5d0316f57d5ba572949aec2b
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal-BMP_responsible_cell\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	TCIRG1 DOCK8 RUBCNL	4.28e-04	200	33	3	01d707c4f8ee0daac635b7260937b1baebc6fc23
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Mesenchymal-Mesoderm\|10w / Sample Type, Dataset, Time_group, and Cell type.	TCIRG1 SPOUT1 SMC1B	4.28e-04	200	33	3	9ef226ebb0a7cdb9431e2fa65faa2a7d67da590d
ToppCell	medial-Hematologic-Proliferating_NK/T-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LMNB1 EZH2 SMC1B	4.28e-04	200	33	3	ab1f9f99cb4a381a642a2cfb32e7f8d276c2dda4
ToppCell	10x5'v1-week_17-19-Lymphocytic_B-B_lineage\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LMNB1 EZH2 RUBCNL	4.28e-04	200	33	3	c28d4ca51d2e2a3a22784ee251975f16a55b0297
ToppCell	356C-Myeloid-Dendritic-cDC_proliferating_1\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	LMNB1 EZH2 SMC1A	4.28e-04	200	33	3	548a0f486ab8745da107f2815914dbf873a6e3c8
ToppCell	medial-Hematologic-Proliferating_NK/T\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LMNB1 EZH2 SMC1B	4.28e-04	200	33	3	bfde42e00a9a6b858937de87cd19c9ed3677d954
ToppCell	10x5'v1-week_17-19-Lymphocytic_B\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LMNB1 EZH2 RUBCNL	4.28e-04	200	33	3	364f09eb9ae4913f5c80a29e943e1c0b2ffd5f93
ToppCell	Biopsy_Control_(H.)-Immune-Proliferating_Macrophages\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	LMNB1 EZH2 SMC1B	4.28e-04	200	33	3	ce9fad55f779afd3d6c5a9c5a15e2d9f548b7c7e
ToppCell	COVID-19-Lymphoid-Proliferating_CD8_T_cells\|Lymphoid / Condition, Lineage and Cell class	LMNB1 EZH2 SMC1A	4.28e-04	200	33	3	4556bb626ca1a00a6db13d2adb35acb8ba848f9c
ToppCell	B_cell_maturation-pre-B\|World / Lineage and Cell class	LMNB1 EZH2 RUBCNL	4.28e-04	200	33	3	acb9ad7e3c05ec38e9700fb27b6eed8eaa565689
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PITPNC1 LMNB1 DOCK8	4.28e-04	200	33	3	20ffb3436d08042f77800513e6ddb3bbc38ae6fe
ToppCell	medial-2-Hematologic-Proliferating_NK/T\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LMNB1 EZH2 SMC1B	4.28e-04	200	33	3	3d1895490dd262e9246eb280938239a7253451dd
ToppCell	(18)_cycling_gd_T\|World / shred on Cell_type and subtype	LMNB1 EZH2 SMC1B	4.47e-04	203	33	3	7d58929058c4769226a29febee1fd8ba64bc9f1a
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	PPARGC1A PPARGC1B EZH2	5.31e-05	65	33	3	DOID:0080208 (biomarker_via_orthology)
Disease	nevus count	PPARGC1B DOCK8	1.84e-04	18	33	2	EFO_0004632
Disease	congestive heart failure (is_implicated_in)	EZH2 SMC1A	4.18e-04	27	33	2	DOID:6000 (is_implicated_in)
Disease	dyslexia	SMARCA2 LMNB1 COG5	7.85e-04	162	33	3	EFO_0005424
Disease	Lymphoma	EZH2 DOCK8	9.21e-04	40	33	2	C0024299

Protein segments in the cluster

Peptide	Gene	Start	Entry
GTEEILDIIFQDFCV	GTPBP3	476	Q969Y2
RIENDFELEEECIFK	RAD51AP2	596	Q09MP3
DGVQCAFEELVEKII	RAB18	156	Q9NP72
GSIVVNEECVRKDFE	RUBCNL	371	Q9H714
NVCIEEIDVDGKFIR	LMNB1	441	P20700
RECGFINDEIFVELV	EZH2	161	Q15910
EFVSDRFVQICKEED	KLHL41	156	O60662
TEVQEFGVCEVRDLK	HUWE1	4176	Q7Z6Z7
RFEVFGEIEECTVNL	PPARGC1A	696	Q9UBK2
CFIEEIVKDGQPEIF	COG5	366	Q9UP83
KFGDLLFEEEVEQCF	DOCK8	1491	Q8NF50
KVSDEFDCGVVFEEV	AXIN1	826	O15169
VDNIDVFCEKGVFDL	AMDHD1	226	Q96NU7
IFCVDEIVVFDEEGQ	SPOUT1	106	Q5T280
ERFIEDKIRQFVDLC	TMEM67	756	Q5HYA8
GVEEQEAFECLKRAF	RTL1	846	A6NKG5
AVERCLEELVFGDVE	UTP18	86	Q9Y5J1
GDIVDIREEIKCDFE	URI1	156	O94763
VERLTCEEEEEKIFG	SMARCA2	1291	P51531
EIDEFCLVEERVSGE	TDRD15	61	B5MCY1
TEDEEERNVFKFICD	TACO1	221	Q9BSH4
FVGEVVEEALDVCEK	TAF11	161	Q15544
RFEVFGEIEECEVLT	PPARGC1B	921	Q86YN6
LEGEFCDIAIVVEDV	ZBTB14	31	O43829
CEEIGVENIREFENK	SMC1B	781	Q8NDV3
EFFEQVEEIRGCIEK	STX1B	31	P61266
NEAKDVEREVCFIDI	PITPNC1	126	Q9UKF7
QVEDEVFEEFCREIG	SMC1A	771	Q14683
IEVRKFVIGFIEEAC	SYMPK	86	Q92797
FVIGFIEEACKRDIE	SYMPK	91	Q92797
LFVEAFERKQECSVE	TEX15	1646	Q9BXT5
FVVDVRRCEELEKTF	TCIRG1	51	Q13488
ECFEFIEEAKRKDGV	DUSP19	131	Q8WTR2
VEFECEVSEEGAQVK	MYBPC3	471	Q14896