Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentspectrin

SPTBN4 SPTBN5

2.00e-049502GO:0008091
DomainPH_dom-spectrin-type

SPTBN4 SPTBN5

2.50e-049502IPR001605
DomainActinin_actin-bd_CS

SPTBN4 SPTBN5

1.71e-0323502IPR001589
DomainSpectrin

SPTBN4 SPTBN5

1.71e-0323502PF00435
DomainACTININ_2

SPTBN4 SPTBN5

1.71e-0323502PS00020
DomainACTININ_1

SPTBN4 SPTBN5

1.71e-0323502PS00019
Domain-

ZNF775 DPF3 ZBTB4 ZNF316 ZFHX2 BCL11A ZNF114

2.09e-036795073.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

ZNF775 DPF3 ZBTB4 ZNF316 ZFHX2 BCL11A ZNF114

2.36e-03694507IPR013087
DomainSpectrin_repeat

SPTBN4 SPTBN5

2.72e-0329502IPR002017
DomainPH

SPTBN4 SPTBN5 PLEKHG3 ARHGAP9

3.26e-03229504PF00169
DomainSpectrin/alpha-actinin

SPTBN4 SPTBN5

3.31e-0332502IPR018159
DomainSPEC

SPTBN4 SPTBN5

3.31e-0332502SM00150
Domain-

LARP6 RBMXL3 RBM15B HTATSF1

4.09e-032445043.30.70.330
DomainZINC_FINGER_C2H2_2

ZNF775 DPF3 ZBTB4 ZNF316 ZFHX2 BCL11A ZNF114

4.35e-03775507PS50157
DomainZINC_FINGER_C2H2_1

ZNF775 DPF3 ZBTB4 ZNF316 ZFHX2 BCL11A ZNF114

4.41e-03777507PS00028
DomainNucleotide-bd_a/b_plait

LARP6 RBMXL3 RBM15B HTATSF1

4.98e-03258504IPR012677
DomainZnf_C2H2-like

ZNF775 DPF3 ZBTB4 ZNF316 ZFHX2 BCL11A ZNF114

5.03e-03796507IPR015880
DomainZnf_C2H2

ZNF775 DPF3 ZBTB4 ZNF316 ZFHX2 BCL11A ZNF114

5.34e-03805507IPR007087
DomainZnF_C2H2

ZNF775 DPF3 ZBTB4 ZNF316 ZFHX2 BCL11A ZNF114

5.45e-03808507SM00355
DomainPH_dom-like

SPTBN4 SPTBN5 PLEKHG3 ARHGAP9 FRMD1

5.50e-03426505IPR011993
DomainPH

SPTBN4 SPTBN5 PLEKHG3 ARHGAP9

6.47e-03278504SM00233
DomainPH_DOMAIN

SPTBN4 SPTBN5 PLEKHG3 ARHGAP9

6.55e-03279504PS50003
DomainPH_domain

SPTBN4 SPTBN5 PLEKHG3 ARHGAP9

6.63e-03280504IPR001849
DomainZnf_FYVE_PHD

DPF3 ZBTB4 BSN

7.15e-03147503IPR011011
Domainzf-C2H2

ZNF775 ZBTB4 ZNF316 ZFHX2 BCL11A ZNF114

1.01e-02693506PF00096
Pubmed

Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation.

DACT1 DVL2

2.19e-06252216446366
Pubmed

ANXA10 promotes melanoma metastasis by suppressing E3 ligase TRIM41-directed PKD1 degradation.

TRIM41 PKD1

6.57e-06352234324862
Pubmed

Myc-interacting zinc-finger protein 1 positively regulates Wnt signalling by protecting Dishevelled from Dapper1-mediated degradation.

DACT1 DVL2

6.57e-06352225558878
Pubmed

Identification of novel rare mutations of DACT1 in human neural tube defects.

DACT1 DVL2

6.57e-06352222610794
Pubmed

Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy.

DACT1 DVL2

1.31e-05452230510196
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

CENPT TRIM41 HTATSF1 MTCL1 NIPBL

1.58e-0521052516565220
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

SPTBN4 SIPA1L3 RBM15B HTATSF1 MTCL1 ZFC3H1

1.63e-0536152626167880
Pubmed

Protein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradation.

DACT1 DVL2

2.19e-05552221262972
Pubmed

Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice.

DACT1 DVL2

3.28e-05652220145239
Pubmed

All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases.

DACT1 DVL2

6.10e-05852221718540
Pubmed

The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy.

DACT1 DVL2

7.84e-05952225825496
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SPTBN4 CACNA1A SIPA1L3 DVL2 MTCL1 BCL11A BSN NIPBL

8.58e-0596352828671696
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RTEL1 PLEKHG3 SIPA1L3 ZBTB4 ZFC3H1 PNKD

9.22e-0549352615368895
Pubmed

Multiple roles of integrin-α3 at the neuromuscular junction.

CACNA1A BSN

1.43e-041252228386022
Pubmed

alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.

SPTBN4 SPTBN5

1.69e-041352218796539
Pubmed

Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.

CACNA1A BSN

1.97e-041452221228161
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

SIPA1L3 DVL2 BSN NYAP1

3.21e-0421852433378226
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

SPTBN4 ANKRD44 LRFN2 RTEL1 PLEKHG3 SIPA1L3 RASGEF1C ZFHX2 PAM16

3.29e-04148952928611215
Pubmed

Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.

SPTBN4 SPTBN5

3.30e-041852212119179
Pubmed

Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak.

DACT1 DVL2

3.30e-041852219701191
Pubmed

The Exonuclease Trex2 Shapes Psoriatic Phenotype.

IL17C TREX2

4.52e-042152227365293
Pubmed

Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis.

PKD1 DVL2

4.97e-042252227582005
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PLEKHG3 SIPA1L3 ZFC3H1

5.31e-041055239628581
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

ANKRD44 TRIM41 SIPA1L3 MTCL1 USP54

5.37e-0444652524255178
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SPTBN4 LARP6 SIPA1L3 ZBTB4 PKD1 USP54 ZFC3H1 NIPBL

6.02e-04128552835914814
Pubmed

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

SPTBN4 SPTBN5

6.43e-04255228493579
Pubmed

The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.

CACNA1A RBM15B

1.12e-033352219336002
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DACT1 KIF26A SIPA1L3 ZBTB4 PKD1 ZNF316 ATP13A2

1.23e-03110552735748872
Cytoband19q13.13

SPTBN4 SIPA1L3

1.31e-041552219q13.13
GeneFamilyEF-hand domain containing|Spectrins

SPTBN4 SPTBN5

8.97e-0573821113
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

ZFC3H1 BSN

4.44e-041538226
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF775 ZBTB4 ZNF316 ZFHX2 BCL11A ZNF114

3.58e-0371838628
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

SPTBN4 PLEKHG3 ARHGAP9

9.17e-03206383682
GeneFamilyRNA binding motif containing

RBMXL3 RBM15B HTATSF1

1.00e-02213383725
GeneFamilyAnkyrin repeat domain containing

ANKRD44 ANKRD65 SOWAHD

1.42e-02242383403
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN4 CACNA1A BSN NYAP1 C8orf34

2.54e-061865257278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN4 CACNA1A BSN NYAP1 C8orf34

3.04e-06193525be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN4 CACNA1A BSN NYAP1 C8orf34

3.04e-061935250c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN4 CACNA1A BSN NYAP1 C8orf34

3.04e-061935258689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-B_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ANKRD44 ARHGAP9 BCL11A ZNF114

4.12e-051655247039bb5a7af4684fbd1192230864e5cd6936e83c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-B_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ANKRD44 ARHGAP9 BCL11A ZNF114

4.12e-05165524d2c79653710b139794170f3d72f11392fc548ac7
ToppCell367C-Myeloid-Dendritic-pDC|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

NEURL1 THSD1 ATP13A2 ZNF114

4.62e-05170524fbb7019c6fba87326702b51f6819ea1af5f3a9b7
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIF26A RASGEF1C RBM15B ZFHX2

4.73e-05171524b51bbeacb172e8b5de519ada85543d7ae9914b3c
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-6|TCGA-Pancreas / Sample_Type by Project: Shred V9

KIF26A PLIN5 HRC ARHGAP9

5.06e-051745249ad13d4613c4f80bdd8033cc1ecf60eda7c0e6e5
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IL17C RASGEF1C NYAP1 C8orf34

5.53e-05178524a9ba4089413b1c55d667ce836b6972ca572ee2b8
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IL17C RASGEF1C NYAP1 C8orf34

5.53e-0517852413dfd28a80889c2dacdc65b94a41bb9762dc409d
ToppCellfacs-Marrow-B-cells-3m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DACT1 LRFN2 LARP6 NEURL1

5.77e-05180524c54af6fb11484dacd3efa1f10a487376ff820a5e
ToppCellfacs-Marrow-B-cells-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DACT1 LRFN2 LARP6 NEURL1

5.77e-0518052407ac979b21be2425294d9818c48b5a1e6f014c19
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN4 CACNA1A MTCL1 BSN

6.98e-05189524f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCellGlobus_pallidus-Neuronal|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SPTBN4 BSN NYAP1 C8orf34

7.12e-05190524416de85d8841dac883faa6f5339b2fb461a09e82
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A NEURL1 MTCL1 BSN

7.56e-051935245fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell(4)_Endothelial_cells-(4)_Lymph_vessel|(4)_Endothelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

PLEKHG3 PLIN5 THSD1 C8orf34

7.72e-051945249735b86d3b2480a0b34d8aab8e7bd609d83c2454
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-B-B_cell-B_mature|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ANKRD44 DPF3 BCL11A GDF9

8.35e-051985244aa4ae2571effcfb6eb6923f7173cd3e7e4af9ef
Diseasereticulocyte count

DPF3 SOWAHD PKD1 ARHGAP9 BCL11A BSN PNKD NYAP1

1.90e-041045468EFO_0007986
Diseasecortical thickness, neuroimaging measurement

DACT1 PNKD LINC02915

6.81e-04110463EFO_0004346, EFO_0004840
Diseasefunctional brain measurement, language measurement

DACT1 LINC02915

8.76e-0428462EFO_0007797, EFO_0007849
Diseasetriacylglycerol 58:10 measurement

SOWAHD C8orf34

1.29e-0334462EFO_0010437
DiseaseSclerocystic Ovaries

SPTBN4 BCL11A GDF9

1.48e-03144463C1136382
DiseasePolycystic Ovary Syndrome

SPTBN4 BCL11A GDF9

1.48e-03144463C0032460

Protein segments in the cluster

PeptideGeneStartEntry
SPRTGADGEHRRHRA

CACNA1A

946

O00555
RAATHARGRGRASHA

C8orf34

31

Q49A92
HEQARSSPGERHGSR

FLG

1346

P20930
EQARSSPGERHGSRH

FLG

1671

P20930
DGSRHPRSHQEDRAG

FLG

2601

P20930
HEQARSSPGERHGSR

FLG

3291

P20930
RDGSRHPGSSHRDTA

FLG

3896

P20930
RRDSSEHGAGGHRTG

DVL2

166

O14641
GHRDGRGTGDANHRA

RBM15B

66

Q8NDT2
ELHRRADGDTGSHGL

MTCL1

966

Q9Y4B5
GGRRRHDAASQEDHD

DPF3

181

Q92784
RSDRFRHHGGHAVSS

BSN

3591

Q9UPA5
AARHHENSSRGAVVG

BCL11A

521

Q9H165
DRRSSGDHRRSGHSH

NIPBL

1121

Q6KC79
GDHRRSGHSHEGRRS

NIPBL

1126

Q6KC79
DNTRGFHGHERSRAC

LARP6

476

Q9BRS8
RAAHSRVHELSASGA

KIF26A

1561

Q9ULI4
EAASHRGRHERPSAT

IL17C

71

Q9P0M4
SDRGGRTALHHAALN

ANKRD44

136

Q8N8A2
DRHGRSALHRAAARG

ANKRD65

266

E5RJM6
GRHLREAGHEAEAGS

NBAS

2331

A2RRP1
SERAGPSRARHFSEH

HTATSF1

391

O43719
GAAEGSRRADTHHAR

PANO1

186

I0J062
QADLGEHRESAHAGR

FRMD1

191

Q8N878
GRSCDDVHRSRHGLS

ATP13A2

191

Q9NQ11
HRAGSRAHGHGREAV

DACT1

651

Q9NYF0
GRSHGARSVGRSAHI

CENPT

61

Q96BT3
AAEDGRSSHHRHRRG

GDF9

306

O60383
DSRSGHRHLDGDRAF

PKD1

3146

P98161
ARIHHGDRGGSRTAL

NYAP1

691

Q6ZVC0
HPDAGHRRTAQRSDA

RTEL1

426

Q9NZ71
GSGDASSSRHHHRRR

TRIM41

521

Q8WV44
DHSGGNRDLSRRHRD

PNKD

176

Q8N490
AHRGALASSEDRARA

TAPBPL

46

Q9BX59
NAEHHDAGFSVRRRE

PLEKHG3

726

A1L390
GGREAAGRSHHADRR

SIPA1L3

1346

O60292
AGRSHHADRRREVSP

SIPA1L3

1351

O60292
ARGHRGHGSEDTEDS

HRC

131

P23327
GADATRRDHSGHRAC

SOWAHD

211

A6NJG2
AHAELLRRAEARGHG

SPTBN5

3086

Q9NRC6
CRAQAHAADRGERGH

LINC02915

146

Q8N8G6
GREALASHLRSSAHR

ZFHX2

2506

Q9C0A1
DGDLRFHALRAGAHV

NEURL1

291

O76050
HEARSGGRSTDAHSR

RBMXL3

431

Q8N7X1
GRSHDTHSRGRSPDA

RBMXL3

866

Q8N7X1
RGAAHRSLTAHSSRE

RASGEF1C

346

Q8N431
RGGPSERSHARNAHF

THSD1

636

Q9NS62
RAHARDRQGSRAGLH

ZNF775

211

Q96BV0
EAHGGGSHSSRAGRR

ZBTB4

746

Q9P1Z0
TAAALSRHGQRHAAE

ZBTB4

776

Q9P1Z0
FGHDEASSRRLARQH

SPTBN4

801

Q9H254
SSVDLRGAALAHGRH

ARHGAP9

381

Q9BRR9
SRAAADARGRAGHRS

PAM16

31

Q9Y3D7
DARGRAGHRSAAASN

PAM16

36

Q9Y3D7
ECGARFARGSHLAAH

ZNF316

751

A6NFI3
GAGFSRRAHLTAHGR

ZNF316

781

A6NFI3
RRAHLTAHGRAHTGE

ZNF316

786

A6NFI3
AAALAEGRGRVAHAH

PLIN5

341

Q00G26
LRGLDRAHSHGTRAR

TREX2

151

Q9BQ50
FSRSRHASERGHLRG

ZFC3H1

86

O60293
REDGSLRAHNTHGRE

ZNF114

231

Q8NC26
GSADGMGRRLHSAHD

USP54

1351

Q70EL1
GRGAGTSARGHHSDR

LRFN2

681

Q9ULH4