Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainKinase-like_dom

TTBK2 MAST2 WNK1 PRDM2 ROR2

1.58e-03542305IPR011009
DomainZnf_CCCH

NUP42 CNOT4

3.90e-0358302IPR000571
DomainZF_C3H1

NUP42 CNOT4

3.90e-0358302PS50103
DomainPROTEIN_KINASE_ATP

TTBK2 MAST2 WNK1 ROR2

5.95e-03459304PS00107
DomainProt_kinase_dom

TTBK2 MAST2 WNK1 ROR2

7.42e-03489304IPR000719
DomainPROTEIN_KINASE_DOM

TTBK2 MAST2 WNK1 ROR2

7.63e-03493304PS50011
Pubmed

CNOT4 suppresses nonsmall cell lung cancer progression by promoting the degradation of PAF1.

PAF1 CNOT4

7.19e-07230237493105
Pubmed

Protein Degradation of RNA Polymerase II-Association Factor 1(PAF1) Is Controlled by CNOT4 and 26S Proteasome.

PAF1 CNOT4

4.31e-06430225933433
Pubmed

Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.

MED1 DBF4

1.51e-05730229997176
Pubmed

De novo genic mutations among a Chinese autism spectrum disorder cohort.

CHD8 MOV10

4.72e-051230227824329
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

SASS6 CHD8 MED1 HMGXB4 SMTN

4.85e-0547230538943005
Pubmed

A human MAP kinase interactome.

CHD8 NCKAP5 MUC12 NUP42 WNK1

5.57e-0548630520936779
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MAST2 PCLO ARNT2

5.85e-058730312465718
Pubmed

UPF2 is a critical regulator of liver development, function and regeneration.

ADHFE1 HMGXB4

1.96e-042430220657840
Pubmed

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

CHD8 MED1 HMGXB4

2.10e-0413430325452129
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

CEACAM4 NCKAP5 MAST2 WNK1

2.58e-0436330414691545
Pubmed

Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development.

CHD8 WNK1

2.68e-042830238324473
Pubmed

Expression of genes involved in mammalian meiosis during the transition from egg to embryo.

DBF4 CNOT4

3.74e-043330211389549
Pubmed

TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.

MED1 PAF1

3.74e-043330233567268
Pubmed

Analysis of mouse embryonic patterning and morphogenesis by forward genetics.

TTBK2 ROR2

3.74e-043330215755804
Pubmed

Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics.

TTBK2 SMTN

4.45e-043630215717329
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

DCBLD1 NUP42 ROR2

4.99e-0418030335198878
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

NUP42 PAF1 DBF4 HMGXB4 ARNT2

5.88e-0480830520412781
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

MAST2 WNK1 PCLO MOV10

6.41e-0446230431138677
Pubmed

The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.

CHD8 MED1 MOV10

6.68e-0419930336688959
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

STIM1 MAST2 WNK1 CNOT4 ROR2

7.83e-0486130536931259
InteractionCEP164 interactions

SASS6 TTBK2 NCKAP5 MOV10

3.26e-05128294int:CEP164
InteractionTNRC6A interactions

SASS6 MED1 WNK1 CNOT4 MOV10

4.51e-05280295int:TNRC6A
InteractionH2BC21 interactions

CHD8 ADHFE1 PAF1 GPR50 PCLO PRDM2 HMGXB4

4.57e-05696297int:H2BC21
Cytoband7q22

MUC12 CNOT4

2.86e-04383027q22
GeneFamilyPDZ domain containing

MAST2 PCLO

1.21e-021522021220
ToppCellfacs-Lung-EPCAM-24m-Epithelial-lung_neuroendocrine_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BEST3 SGSM1 PCLO ARNT2

7.91e-061913048e06cc61eaff1796c2ce014074029408ba88d561
ToppCellfacs-Lung-EPCAM-24m-Epithelial-Neuroendocrine|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BEST3 SGSM1 PCLO ARNT2

7.91e-06191304501d4f6ad389d9ac5051d4247b9bd3da96f713f9
DrugOxamniquine [21738-42-1]; Up 200; 14.4uM; MCF7; HT_HG-U133A

TTBK2 MAST2 PIK3R5 CNOT4 PRDM2

5.51e-061973057344_UP
Drugeg D

MUC12 WNK1 CNOT4

1.20e-0534303CID000029544
Diseasenicotine dependence symptom count, depressive symptom measurement

SGSM1 PCLO

2.48e-0375292EFO_0007006, EFO_0009262
Diseasedilated cardiomyopathy (implicated_via_orthology)

STIM1 MED1

2.81e-0380292DOID:12930 (implicated_via_orthology)
DiseaseAutism Spectrum Disorders

CHD8 GPR50

3.17e-0385292C1510586
Diseaseatrial fibrillation

STIM1 DCBLD1 BEST3

5.65e-03371293EFO_0000275
Diseasehypertension (is_implicated_in)

WNK1 MOV10

6.30e-03121292DOID:10763 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
PVPTSGGYHHDSATS

BEST3

511

Q8N1M1
SSPASSAPHSGGKTG

CHD8

431

Q9HCK8
STPGHGPSHRSTFSA

CEACAM4

196

O75871
TTSPHPSHDGSSFKS

DBF4

116

Q9UBU7
SPFPSGHSGKAFSSS

ARNT2

526

Q9HBZ2
VSGHSKPASGHPKSA

GPR50

421

Q13585
AFSAATSHPKPTTGH

GPR50

491

Q13585
KGSHVHSGPTSAGSS

PCLO

4646

Q9Y6V0
SFGHGPSDTSKPTHP

HERC6

311

Q8IVU3
KHKSSSDAHSSPGPE

HMGXB4

251

Q9UGU5
HGGKGSASSSTPAHT

GREB1L

286

Q9C091
GSPGSHSHTAFSKPS

NUP42

346

O15504
HSRSASPFPSGSEHS

PAF1

496

Q8N7H5
SSGESGPGSPTHSHS

MAST2

1256

Q6P0Q8
SSPAGSGHTRPSSLH

MAST2

1306

Q6P0Q8
PQPGHKHSLSSGGFS

DCBLD1

626

Q8N8Z6
FPHSISAKNTSHPGS

SASS6

541

Q6UVJ0
AGSPSSDSPTNHFFH

MED1

846

Q15648
SHSSKKGGHSSPASS

PRDM2

1491

Q13029
HSHTYSQAPGLSPSG

ADHFE1

26

Q8IWW8
HSFSTHSGDKPSTPP

NCKAP5

1276

O14513
SKLSPSTSGPHSHDY

MOV10

966

Q9HCE1
VPKPSSHHSGSGSTS

ROR2

856

Q01974
GGSPHLDSSRSHSPS

STIM1

606

Q13586
SHTTTAKGPGSGFLH

CNOT4

441

O95628
PTSGHTSQGSGHAFP

ZP1

166

P60852
KLSTPGHSPHSAYTT

PIK3R5

181

Q8WYR1
GRSKSPPSHSGSSSS

TTBK2

1186

Q6IQ55
GTCSPDSGHPSSHNF

SGSM1

761

Q2NKQ1
GSGSPHSPHQLSSKS

WNK1

2026

Q9H4A3
HVTSFSHAPPSSRGG

SMTN

526

P53814
PGLSRHSTTSHSSPG

MUC12

1016

Q9UKN1
PGLSRHSTTSHSSPG

MUC12

3656

Q9UKN1
FHSSPGSTHTTLFPD

MUC12

3721

Q9UKN1