Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP hydrolysis activity	ATP5PB DDX46 MDN1 DYNC2H1 DDX54 TOR1A CHD6 TOR1B ASCC3 TOR3A DNAH6 ATP2B4 VCP	1.18e-09	441	64	13	GO:0016887
GeneOntologyMolecularFunction	ATP-dependent activity	ATP5PB ATP6V0A1 DDX46 MDN1 DYNC2H1 DDX54 TOR1A CHD6 TOR1B ASCC3 TOR3A DNAH6 ATP2B4 VCP	6.76e-09	614	64	14	GO:0140657
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	ATP5PB DDX46 MDN1 DYNC2H1 DDX54 TOR1A CHD6 TOR1B ASCC3 TOR3A DNAH6 ATP2B4 VCP	8.64e-07	775	64	13	GO:0017111
GeneOntologyMolecularFunction	pyrophosphatase activity	ATP5PB DDX46 MDN1 DYNC2H1 DDX54 TOR1A CHD6 TOR1B ASCC3 TOR3A DNAH6 ATP2B4 VCP	2.09e-06	839	64	13	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	ATP5PB DDX46 MDN1 DYNC2H1 DDX54 TOR1A CHD6 TOR1B ASCC3 TOR3A DNAH6 ATP2B4 VCP	2.12e-06	840	64	13	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	ATP5PB DDX46 MDN1 DYNC2H1 DDX54 TOR1A CHD6 TOR1B ASCC3 TOR3A DNAH6 ATP2B4 VCP	2.12e-06	840	64	13	GO:0016818
GeneOntologyMolecularFunction	ferric-chelate reductase (NADPH) activity	STEAP3 STEAP2	1.01e-04	5	64	2	GO:0052851
GeneOntologyMolecularFunction	ferric-chelate reductase activity	STEAP3 STEAP2	1.01e-04	5	64	2	GO:0000293
GeneOntologyMolecularFunction	cupric reductase (NADH) activity	STEAP3 STEAP2	1.01e-04	5	64	2	GO:0008823
GeneOntologyMolecularFunction	oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor	STEAP3 STEAP2	2.10e-04	7	64	2	GO:0016723
GeneOntologyMolecularFunction	mRNA regulatory element binding translation repressor activity	CPEB2 CPEB4	1.33e-03	17	64	2	GO:0000900
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DYNC2H1 DNAH6	1.50e-03	18	64	2	GO:0008569
GeneOntologyMolecularFunction	oxidoreductase activity, acting on metal ions	STEAP3 STEAP2	1.50e-03	18	64	2	GO:0016722
GeneOntologyMolecularFunction	helicase activity	DDX46 DDX54 CHD6 ASCC3	1.66e-03	158	64	4	GO:0004386
GeneOntologyMolecularFunction	scaffold protein binding	GRM3 ATP2B4 ADCY5	3.32e-03	93	64	3	GO:0097110
Domain	Torsin	TOR1A TOR1B TOR3A	3.82e-07	5	64	3	IPR010448
Domain	Torsin	TOR1A TOR1B TOR3A	3.82e-07	5	64	3	PF06309
Domain	AAA+_ATPase	MDN1 DYNC2H1 TOR1B ASCC3 DNAH6 VCP	9.82e-06	144	64	6	IPR003593
Domain	AAA	MDN1 DYNC2H1 TOR1B ASCC3 DNAH6 VCP	9.82e-06	144	64	6	SM00382
Domain	ATPase_dyneun-rel_AAA	MDN1 DYNC2H1 DNAH6	1.36e-05	14	64	3	IPR011704
Domain	AAA_5	MDN1 DYNC2H1 DNAH6	1.36e-05	14	64	3	PF07728
Domain	Torsin_1/2	TOR1A TOR1B	3.46e-05	3	64	2	IPR017378
Domain	-	DDX46 MDN1 DYNC2H1 DDX54 TOR1A CHD6 TOR1B ASCC3 TOR3A DNAH6 VCP	4.12e-05	746	64	11	3.40.50.300
Domain	CEBP_ZZ	CPEB2 CPEB4	6.90e-05	4	64	2	IPR032296
Domain	CEBP_ZZ	CPEB2 CPEB4	6.90e-05	4	64	2	PF16366
Domain	RRM_7	CPEB2 CPEB4	6.90e-05	4	64	2	PF16367
Domain	P-loop_NTPase	DDX46 MDN1 DYNC2H1 DDX54 TOR1A CHD6 TOR1B ASCC3 TOR3A DNAH6 VCP	1.30e-04	848	64	11	IPR027417
Domain	ProC_N	STEAP3 STEAP2	2.40e-04	7	64	2	IPR028939
Domain	F420_oxidored	STEAP3 STEAP2	2.40e-04	7	64	2	PF03807
Domain	ClpA/B	TOR1A TOR1B	2.40e-04	7	64	2	IPR001270
Domain	Helicase_C	DDX46 DDX54 CHD6 ASCC3	4.97e-04	107	64	4	PF00271
Domain	HELICc	DDX46 DDX54 CHD6 ASCC3	4.97e-04	107	64	4	SM00490
Domain	Helicase_C	DDX46 DDX54 CHD6 ASCC3	5.14e-04	108	64	4	IPR001650
Domain	HELICASE_CTER	DDX46 DDX54 CHD6 ASCC3	5.33e-04	109	64	4	PS51194
Domain	HELICASE_ATP_BIND_1	DDX46 DDX54 CHD6 ASCC3	5.33e-04	109	64	4	PS51192
Domain	DEXDc	DDX46 DDX54 CHD6 ASCC3	5.33e-04	109	64	4	SM00487
Domain	Helicase_ATP-bd	DDX46 DDX54 CHD6 ASCC3	5.51e-04	110	64	4	IPR014001
Domain	SANT	MIS18BP1 CHD6 TTF1	6.70e-04	50	64	3	SM00717
Domain	Ferric_reduct	STEAP3 STEAP2	7.46e-04	12	64	2	PF01794
Domain	Fe3_Rdtase_TM_dom	STEAP3 STEAP2	7.46e-04	12	64	2	IPR013130
Domain	SANT/Myb	MIS18BP1 CHD6 TTF1	7.52e-04	52	64	3	IPR001005
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DNAH6	1.02e-03	14	64	2	IPR024317
Domain	Dynein_HC_stalk	DYNC2H1 DNAH6	1.02e-03	14	64	2	IPR024743
Domain	Dynein_heavy_dom-2	DYNC2H1 DNAH6	1.02e-03	14	64	2	IPR013602
Domain	DHC_N2	DYNC2H1 DNAH6	1.02e-03	14	64	2	PF08393
Domain	MT	DYNC2H1 DNAH6	1.02e-03	14	64	2	PF12777
Domain	AAA_8	DYNC2H1 DNAH6	1.02e-03	14	64	2	PF12780
Domain	DHC_fam	DYNC2H1 DNAH6	1.18e-03	15	64	2	IPR026983
Domain	Dynein_heavy_dom	DYNC2H1 DNAH6	1.18e-03	15	64	2	IPR004273
Domain	Dynein_heavy	DYNC2H1 DNAH6	1.18e-03	15	64	2	PF03028
Domain	DEAD/DEAH_box_helicase_dom	DDX46 DDX54 ASCC3	2.01e-03	73	64	3	IPR011545
Domain	DEAD	DDX46 DDX54 ASCC3	2.01e-03	73	64	3	PF00270
Domain	GPCR_3	GRM3 GPR179	2.33e-03	21	64	2	IPR000337
Domain	7tm_3	GRM3 GPR179	2.55e-03	22	64	2	PF00003
Domain	G_PROTEIN_RECEP_F3_2	GRM3 GPR179	2.55e-03	22	64	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GRM3 GPR179	2.55e-03	22	64	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GRM3 GPR179	2.55e-03	22	64	2	PS00979
Domain	G_PROTEIN_RECEP_F3_4	GRM3 GPR179	2.55e-03	22	64	2	PS50259
Domain	GPCR_3_C	GRM3 GPR179	2.55e-03	22	64	2	IPR017978
Domain	Rho_GTPase_activation_prot	DLC1 BCR IQGAP3	3.42e-03	88	64	3	IPR008936
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	ATP5PB MGAT1 ATP6V0A1 NDC1 DYNC2H1 PIGS MTX3 HNRNPM SLC19A2 ASCC3 ATP2B4 IQGAP3 ZMYM3 VCP	1.76e-09	942	65	14	31073040
Pubmed	The TOR1A (DYT1) gene family and its role in early onset torsion dystonia.	TOR1A TOR1B TOR3A	2.49e-08	4	65	3	10644435
Pubmed	Relative tissue expression of homologous torsinB correlates with the neuronal specific importance of DYT1 dystonia-associated torsinA.	TOR1A TOR1B TOR3A	6.21e-08	5	65	3	20015956
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	ATP5PB NDC1 MDN1 DYNC2H1 PIGS HNRNPM SLC19A2 TOR1A STEAP3 TOR1B STEAP2 TTF1 ATP2B4	6.96e-08	1061	65	13	33845483
Pubmed	Defining the membrane proteome of NK cells.	ATP5PB MGAT1 NDC1 MDN1 PIGS SCARB2 HNRNPM DDX54 ASCC3 BCR CNOT1 ATP2B4 ANKRD27	2.10e-07	1168	65	13	19946888
Pubmed	Regulation of Torsin ATPases by LAP1 and LULL1.	TOR1A TOR1B TOR3A	3.47e-07	8	65	3	23569223
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	CPEB2 ATP5PB ATP6V0A1 CPEB4 HNRNPM ALB SSB GRM3 BCR DNAH6 CNOT1 ATP2B4 VCP	2.05e-06	1431	65	13	37142655
Pubmed	A molecular mechanism underlying the neural-specific defect in torsinA mutant mice.	TOR1A TOR1B TOR3A	2.79e-06	15	65	3	20457914
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ATP5PB ATP6V0A1 NDC1 MDN1 DYNC2H1 HNRNPM DDX54 TOR1A STEAP3 DDHD2 ASCC3 ATP2B4 VCP	3.12e-06	1487	65	13	33957083
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DDX46 MDN1 DDX54 SSB ASCC3 TTF1 CNOT1 ZMYM3 VCP	3.44e-06	653	65	9	22586326
Pubmed	Immunocytochemical characterization of torsin proteins in mouse brain.	TOR1A TOR1B	3.44e-06	2	65	2	11730696
Pubmed	Genetic evidence for an association of the TOR1A locus with segmental/focal dystonia.	TOR1A TOR1B	3.44e-06	2	65	2	20669276
Pubmed	The CCR4-NOT complex maintains liver homeostasis through mRNA deadenylation.	ALB CNOT1	3.44e-06	2	65	2	32238456
Pubmed	Developmental patterns of torsinA and torsinB expression.	TOR1A TOR1B	3.44e-06	2	65	2	16458269
Pubmed	Neuronal Nuclear Membrane Budding Occurs during a Developmental Window Modulated by Torsin Paralogs.	TOR1A TOR1B	3.44e-06	2	65	2	27653693
Pubmed	TorsinB--perinuclear location and association with torsinA.	TOR1A TOR1B	3.44e-06	2	65	2	15147511
Pubmed	Strong genetic evidence for association of TOR1A/TOR1B with idiopathic dystonia.	TOR1A TOR1B	3.44e-06	2	65	2	17130424
Pubmed	Cellular distribution of torsin A and torsin B in normal human brain.	TOR1A TOR1B	3.44e-06	2	65	2	11405807
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	EDEM3 DDX46 NDC1 CEP120 SSB PPP2R3C CNOT1 DCAF4 IQGAP3 ZMYM3 VCP	8.94e-06	1155	65	11	20360068
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	MIS18BP1 NDC1 CPEB4 HNRNPM TDO2 CNOT1	1.00e-05	263	65	6	34702444
Pubmed	CPEB2, a novel putative translational regulator in mouse haploid germ cells.	CPEB2 CPEB4	1.03e-05	3	65	2	12672660
Pubmed	Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer.	STEAP3 STEAP2	1.03e-05	3	65	2	12095985
Pubmed	STAMPing at the crossroads of normal physiology and disease states.	STEAP3 STEAP2	1.03e-05	3	65	2	26911931
Pubmed	The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein.	TOR1A TOR1B	1.03e-05	3	65	2	9288096
Pubmed	Global Analysis of CPEBs Reveals Sequential and Non-Redundant Functions in Mitotic Cell Cycle.	CPEB2 CPEB4	1.03e-05	3	65	2	26398195
Pubmed	Inter-organ insulin-leptin signal crosstalk from the liver enhances survival during food shortages.	ALB LEPR	1.03e-05	3	65	2	37116488
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	DDX46 MDN1 HNRNPM DDX54 SSB ASCC3 TTF1 CNOT1 IQGAP3	1.15e-05	759	65	9	35915203
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	CPEB2 DDX46 CPEB4 HNRNPM DDX54 SSB ASCC3 CNOT1 VCP	1.87e-05	807	65	9	22681889
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ATP5PB DDX46 NDC1 MDN1 DDX54 TOR1A ALB ASCC3 CNOT1 VCP	1.93e-05	1024	65	10	24711643
Pubmed	CPEB2-dependent translation of long 3'-UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue.	CPEB2 CPEB4	2.06e-05	4	65	2	30177570
Pubmed	MiR-34a Regulates Axonal Growth of Dorsal Root Ganglia Neurons by Targeting FOXP2 and VAT1 in Postnatal and Adult Mouse.	FOXP2 LEPR	2.06e-05	4	65	2	29637443
Pubmed	Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus.	CPEB2 CPEB4	2.06e-05	4	65	2	12871996
Pubmed	TorsinB overexpression prevents abnormal twisting in DYT1 dystonia mouse models.	TOR1A TOR1B	2.06e-05	4	65	2	32202496
Pubmed	Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein.	IQGAP3 VCP	2.06e-05	4	65	2	28970065
Pubmed	Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans.	MGAT1 LEPR	2.06e-05	4	65	2	29853530
Pubmed	Predictive potential of STEAP family for survival, immune microenvironment and therapy response in glioma.	STEAP3 STEAP2	2.06e-05	4	65	2	34649092
Pubmed	ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.	ATP5PB ATP6V0A1 NDC1 PIGS DDX54 VCP	2.07e-05	299	65	6	37931956
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	ATP5PB DDX46 MDN1 HNRNPM SSB ASCC3 CNOT1 VCP	2.47e-05	638	65	8	33239621
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	ATP6V0A1 MDN1 SCARB2 HNRNPM ASCC3 CNOT1 VCP	3.36e-05	484	65	7	31995728
Pubmed	A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons.	CPEB2 CPEB4	3.43e-05	5	65	2	20639532
Pubmed	The Steap proteins are metalloreductases.	STEAP3 STEAP2	3.43e-05	5	65	2	16609065
Pubmed	Interaction of torsinA with its major binding partners is impaired by the dystonia-associated DeltaGAG deletion.	TOR1A TOR3A	3.43e-05	5	65	2	19651773
Pubmed	Clinical exome sequencing in early-onset generalized dystonia and large-scale resequencing follow-up.	TOR1A ADCY5	3.43e-05	5	65	2	27666935
Pubmed	Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate.	STEAP3 STEAP2	3.43e-05	5	65	2	12429817
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	NDC1 MDN1 PIGS MTX3 TOR1A TOR1B TOR3A BCR	4.12e-05	686	65	8	28380382
Pubmed	Mouse disabled (mDab1): a Src binding protein implicated in neuronal development.	FOXD2 LEPR	5.13e-05	6	65	2	9009273
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	ATP5PB DDX46 NDC1 MDN1 PIGS SCARB2 DDX54 SSB ASCC3 CNOT1 VCP	6.75e-05	1440	65	11	30833792
Pubmed	Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes.	ALB TDO2 CNOT1	7.29e-05	43	65	3	30733279
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	MGAT1 MIS18BP1 NDC1 PIGS SCARB2 HNRNPM STEAP3 CNOT1 ZMYM3 VCP	7.50e-05	1203	65	10	29180619
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	MDN1 HNRNPM DDX54 ALB LEPR	7.85e-05	234	65	5	36243803
Pubmed	Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization.	ATP5PB ATP6V0A1 ALB ATP2B4 ADCY5 VCP	1.08e-04	403	65	6	30562941
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	ATP5PB DDX46 MDN1 HNRNPM DDX54 ALB ASCC3	1.35e-04	605	65	7	28977666
Pubmed	Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2.	FOXD2 FOXP2	1.53e-04	10	65	2	26071365
Pubmed	Deficiency of CPEB2-Confined Choline Acetyltransferase Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction.	CPEB2 CPEB4	1.53e-04	10	65	2	27810937
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	FZD8 CFAP91 NDC1 SSB ASCC3 PPP2R3C ATP2B4 GPR179	1.57e-04	832	65	8	36724073
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	DDX46 MDN1 HNRNPM DDX54 CHD6 ALB SSB ASCC3 TTF1 ANKRD27	1.59e-04	1318	65	10	30463901
Pubmed	BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.	FZD8 SHLD2 GPR179	1.70e-04	57	65	3	27433848
Pubmed	Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer.	ALB TDO2	1.87e-04	11	65	2	10205167
Pubmed	Role of the Drug-Metabolizing Enzyme CYP during Mouse Liver Development.	ALB TDO2	1.87e-04	11	65	2	27904043
Pubmed	Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.	FZD8 EDEM3 PIGS ATP2B4 VCP	1.88e-04	282	65	5	35007762
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	MDN1 CHD6 SSB ASCC3 IQGAP3	1.88e-04	282	65	5	23667531
Pubmed	Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.	DDX46 HNRNPM ALB SSB	2.13e-04	156	65	4	37108203
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	EDEM3 FOXP2 CPEB4 HNRNPM TTC39A ASCC3 BCR ZMYM3 VCP	2.22e-04	1116	65	9	31753913
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	ATP5PB PIGS HNRNPM TOR1A TOR3A CNOT1 VCP	2.24e-04	657	65	7	36180527
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	EDEM3 PIGS TOR1B ALB	2.58e-04	164	65	4	32409323
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	ATP5PB ATP6V0A1 NDC1 MDN1 DYNC2H1 HNRNPM DDX54 SSB CNOT1 IQGAP3	2.97e-04	1425	65	10	30948266
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	DDX46 HNRNPM DDX54 SSB ASCC3 IQGAP3	2.97e-04	486	65	6	30940648
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DYNC2H1 DNAH6	3.08e-04	14	65	2	9373155
Pubmed	Matrix metalloproteinase-14 mediates formation of bile ducts and hepatic maturation of fetal hepatic progenitor cells.	ALB TDO2	3.08e-04	14	65	2	26724533
Pubmed	Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro.	ALB TDO2	3.08e-04	14	65	2	16892178
Pubmed	HIV-host interactome revealed directly from infected cells.	EDEM3 TOR1A TOR3A VCP	3.09e-04	172	65	4	27375898
Pubmed	Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.	PIGS ALB TOR3A VCP	3.23e-04	174	65	4	32149426
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	DDX46 MDN1 TOPAZ1 DDX54 ASCC3 CNOT1	3.35e-04	497	65	6	36774506
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	EDEM3 ATP6V0A1 NDC1 PIGS SCARB2 TOR1A TOR1B TOR3A VCP	3.81e-04	1201	65	9	35696571
Pubmed	Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells.	ALB TDO2	4.06e-04	16	65	2	19185577
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	MIS18BP1 MDN1 HNRNPM DDX54 ASCC3	4.43e-04	340	65	5	29478914
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	MDN1 TOPAZ1 HNRNPM KCNS2 CHD6 ALB CNOT1	4.44e-04	736	65	7	29676528
Pubmed	TRIM24 is an insulin-responsive regulator of P-bodies.	HNRNPM ALB CNOT1	4.62e-04	80	65	3	35803934
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	EDEM3 MDN1 PIGS SLC19A2 TOR1A ASCC3 ATP2B4	5.12e-04	754	65	7	33060197
Pubmed	Putative Protein Interactome of the Rhomboid Protease RHBDL4.	NDC1 VCP	5.16e-04	18	65	2	36857408
Pubmed	Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing.	CPEB2 CPEB4	5.16e-04	18	65	2	30111840
Pubmed	Mice without macroH2A histone variants.	PIP5K1B LEPR	5.76e-04	19	65	2	25312643
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	MDN1 CHD6 TM6SF1 DCAF4 LEPR	5.96e-04	363	65	5	14691545
Pubmed	Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability.	HNRNPM ALB VCP	6.31e-04	89	65	3	31267705
Pubmed	Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation.	FOXP2 ALB	6.39e-04	20	65	2	28838957
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	EDEM3 NDC1 PIGS SCARB2 TOR1A TOR1B TOR3A CNOT1 VCP	6.63e-04	1297	65	9	33545068
Pubmed	Regulation of the endosomal SNX27-retromer by OTULIN.	STEAP3 VCP	7.06e-04	21	65	2	31541095
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	CFAP91 CEP120 DYNC2H1 PIGS STEAP3 SSB BCR CNOT1 IQGAP3	7.55e-04	1321	65	9	27173435
Pubmed	HEY1 functions are regulated by its phosphorylation at Ser-68.	DDX46 MIS18BP1 VCP	7.63e-04	95	65	3	27129302
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	ATP5PB MDN1 DYNC2H1 HNRNPM CNOT1 IQGAP3 VCP	7.64e-04	807	65	7	30575818
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	ATP5PB MDN1 HNRNPM SSB ASCC3 CNOT1 VCP	7.75e-04	809	65	7	32129710
Pubmed	FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.	MDN1 PIGS HNRNPM VCP	8.20e-04	223	65	4	34226595
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	MDN1 DDX54 SSB CNOT1 ZMYM3	8.60e-04	394	65	5	27248496
Pubmed	Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.	ATP5PB SCARB2 SSB ASCC3	8.62e-04	226	65	4	37839992
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DDX46 CPEB4 HNRNPM CHD6 ALB CNOT1 ZMYM3 VCP	8.98e-04	1082	65	8	38697112
Pubmed	CPEB2-eEF2 interaction impedes HIF-1α RNA translation.	CPEB2 PIGS	9.24e-04	24	65	2	22157746
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	DLC1 CPEB4 DNAH6	9.37e-04	102	65	3	11214970
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	MDN1 DYNC2H1 DDX54 BCR ANKRD27 IQGAP3	9.44e-04	606	65	6	36538041
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	DDX46 CPEB4 KBTBD8 SSB ASCC3 TTF1 CNOT1 ATP2B4 VCP	9.81e-04	1371	65	9	36244648
Pubmed	Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.	HNRNPM DDX54 VCP	9.92e-04	104	65	3	26167872
Interaction	LMBR1L interactions	ATP5PB MGAT1 ATP6V0A1 NDC1 DYNC2H1 PIGS MTX3 HNRNPM SLC19A2 ASCC3 ATP2B4 IQGAP3 ZMYM3 VCP	1.22e-06	946	64	14	int:LMBR1L
Interaction	DLK1 interactions	MIS18BP1 SLC19A2 STEAP3 ATP2B4 ANKRD27	1.73e-05	101	64	5	int:DLK1
Interaction	CCDC77 interactions	DDX46 CEP120 CPEB4 PPP2R3C	5.09e-05	64	64	4	int:CCDC77
Interaction	DPEP1 interactions	NDC1 MDN1 STEAP3 STEAP2	5.09e-05	64	64	4	int:DPEP1
Interaction	LPAR1 interactions	ATP5PB NDC1 PIGS SLC19A2 ATP2B4 ZMYM3	5.40e-05	210	64	6	int:LPAR1
Interaction	CDCP1 interactions	ALB DCAF4 LEPR	5.89e-05	24	64	3	int:CDCP1
GeneFamily	Proteases, serine\|STEAP family	STEAP3 STEAP2	6.87e-05	5	48	2	1324
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	MIS18BP1 CHD6 TTF1	3.75e-04	53	48	3	532
GeneFamily	RNA binding motif containing	CPEB2 CPEB4 HNRNPM SSB	2.43e-03	213	48	4	725
ToppCell	Severe-Plasmablast\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	EDEM3 MGAT1 SCARB2 CPEB4 VCP	9.23e-06	196	64	5	ee991f1d9936c656f4fbc2e0cec9e0166a34bc5b
ToppCell	Mild/Remission-Plasmablast\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	EDEM3 MGAT1 SCARB2 CPEB4 VCP	9.23e-06	196	64	5	dcf0a804a79a05454658498d1f87320c7e079219
ToppCell	Severe-Plasmablast\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	EDEM3 MGAT1 SCARB2 CPEB4 VCP	9.46e-06	197	64	5	1089aa7991812378668d0f3d57f8000e6245a713
Disease	torsion dystonia 1 (implicated_via_orthology)	TOR1A TOR1B TOR3A	3.19e-08	4	60	3	DOID:0060730 (implicated_via_orthology)
Disease	dystonia (implicated_via_orthology)	TOR1A TOR1B TOR3A	1.74e-06	12	60	3	DOID:543 (implicated_via_orthology)
Disease	Pancreatic Diseases	ALB LEPR	6.07e-05	6	60	2	C0030286
Disease	Nephritis	ALB LEPR	1.45e-04	9	60	2	C0027697
Disease	Fibrosis	ALB ADCY5 LEPR	1.46e-04	50	60	3	C0016059
Disease	Cirrhosis	ALB ADCY5 LEPR	1.46e-04	50	60	3	C1623038
Disease	Unipolar Depression	FOXP2 ALB TDO2 BCR ADCY5	1.85e-04	259	60	5	C0041696
Disease	Jeune thoracic dystrophy	CEP120 DYNC2H1	2.21e-04	11	60	2	C0265275
Disease	uric acid measurement	SHLD2 NDC1 DYNC2H1 CPEB4 KBTBD8 PIP5K1B ZMYM3	2.33e-04	610	60	7	EFO_0004761
Disease	fasting blood glucose measurement	PIP5K1B TDO2 STEAP2 ADCY5 LEPR	2.97e-04	287	60	5	EFO_0004465
Disease	Parkinson's disease (implicated_via_orthology)	TOR1A TOR1B TOR3A ADCY5	2.98e-04	157	60	4	DOID:14330 (implicated_via_orthology)
Disease	Short Rib-Polydactyly Syndrome	CEP120 DYNC2H1	3.13e-04	13	60	2	C0036996
Disease	Saldino-Noonan Syndrome	CEP120 DYNC2H1	3.64e-04	14	60	2	C0036069
Disease	Majewski Syndrome	CEP120 DYNC2H1	3.64e-04	14	60	2	C0024507
Disease	PR interval	FZD8 DLC1 TTC39A CHD6 CNOT1 ADCY5	5.03e-04	495	60	6	EFO_0004462
Disease	primary biliary cholangitis (is_marker_for)	CPEB4 LEPR	1.18e-03	25	60	2	DOID:12236 (is_marker_for)
Disease	Major Depressive Disorder	FOXP2 TDO2 BCR ADCY5	1.52e-03	243	60	4	C1269683
Disease	Drug-Induced Stevens Johnson Syndrome	ALB VCP	1.59e-03	29	60	2	C1274933
Disease	Toxic Epidermal Necrolysis	ALB VCP	1.59e-03	29	60	2	C0014518
Disease	Mycoplasma-Induced Stevens-Johnson Syndrome	ALB VCP	1.59e-03	29	60	2	C3658301
Disease	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum	ALB VCP	1.59e-03	29	60	2	C3658302
Disease	Stevens-Johnson Syndrome	ALB VCP	1.71e-03	30	60	2	C0038325

Protein segments in the cluster

Peptide	Gene	Start	Entry
PKQVFPFRDIFYYED	TTF1	856	Q15361
LPGFYFDPEKKRYFR	DCAF4	66	Q8WV16
DPYYFLQFNKFRVPT	AADAT	231	Q8N5Z0
AFIERYKREPFLLFF	ARSH	251	Q5FYA8
PYFYAPELLFFAKRY	ALB	171	P02768
YFRELPEPLFTDEFY	BCR	1131	P11274
YFARTVPPDFYQAKA	GRM3	186	Q14832
FPSDKLERLYQRYFF	ADCY5	221	O95622
PECTPIYIQYFVKFF	ATP2B4	396	P23634
YGLIPEEFFQFLYPK	ATP5PB	56	P24539
NRYKYFERPFLPFFQ	CFAP91	141	Q7Z4T9
FLFYISKVPERYFPG	PAQR3	251	Q6TCH7
EFYKTIPRFYYRLPA	PPP2R3C	51	Q969Q6
KLYDLPDEPFTRQFY	ANKRD27	926	Q96NW4
YVFGFLAPLYKVRFP	MTX3	201	Q5HYI7
FPFPYYIILRDVNAL	MDN1	5561	Q9NU22
YPNYLIRKFMFGFPE	MIS18BP1	451	Q6P0N0
IEYYFGDFNLPRDKF	SSB	21	P05455
PDFFEYFRATYPLLK	MGAT1	216	P26572
FLLLYFPVFILYFKP	GPR179	426	Q6PRD1
PLRPEFAESTYFLYK	EDEM3	401	Q9BZQ6
FEPYANPTKRYRAFI	HNRNPM	61	P52272
RDQEFYIPYRPKDFD	DDX54	676	Q8TDD1
VYIIGIFRNPFYPKD	PCNX4	411	Q63HM2
FRYFRELFGIKPDDY	PIP5K1B	91	O14986
EFYKNADVRPPFTYA	FOXP2	496	O15409
FFCPVYKDLEPFTYF	GPR171	6	O14626
QREFYFDRNPELFPY	KCNS2	66	Q9ULS6
FDRNPELFPYVLHFY	KCNS2	71	Q9ULS6
KYPRLIYKPEIFFAF	DDHD2	491	O94830
FIPIEKYQFSLYPIF	LEPR	801	P48357
YYRFLNPAVVAPDAF	IQGAP3	1176	Q86VI3
LQGEFFLFYEPQKDY	KBTBD8	446	Q8NFY9
FKYPERPIIFLSACY	FZD8	306	Q9H461
LQFRPPFEEIRAKYY	DYNC2H1	786	Q8NCM8
YLESKRVIFPRFYFL	DNAH6	1181	Q9C0G6
YFPPKGYAFLLFQEE	CPEB2	371	Q7Z5Q1
PPFDLELFYVKYRNF	CHD6	311	Q8TD26
KLPERQPEFFFYYSL	CEP120	211	Q8N960
EGQDPFFYDYKRFLL	ANKMY1	146	Q9P2S6
YFPPKGYAFLLFQDE	CPEB4	511	Q17RY0
IEYEPFRKNFYVEVP	DDX46	326	Q7L014
FPVFLATDYLRYKPV	SLC19A2	86	O60779
LYFPDDQKFAIYIPL	PIGS	511	Q96S52
FISGRFPYYREKFPA	FOXD2	156	O60548
LRPYFQVYQYSPLFL	TRIM38	446	O00635
YFYREEPRFQVPFQL	TDO2	296	P48775
YPLQQDFSLLDFYPD	SHLD2	811	Q86V20
FRPDISPYFGLFYEK	SCARB2	191	Q14108
KRAFEEEYYRFYTPP	STEAP2	416	Q8NFT2
PQYAQLYEDFLFPID	DLC1	466	Q96QB1
DFYKKFLYEPFPVES	ASCC3	1711	Q8N3C0
FEEYRFFPQYPDKEL	CNOT1	896	A5YKK6
NLIDYFVPFLPLEYK	TOR1A	261	O14656
QAPFYPKFLAYSRDT	SPEM3	556	A0A1B0GUW6
TRAFEESRYKFYLPP	STEAP3	416	Q658P3
FEVYLKPYFLEAYRP	VCP	131	P55072
EYYRKFPPGVYFDLQ	TOPAZ1	1151	Q8N9V7
YFKKPLNIYFGFIPE	ATP6V0A1	561	Q93050
ENLIDYFIPFLPLEY	TOR3A	326	Q9H497
PYLNRYPKGAIFLFF	TTC39A	306	Q5SRH9
SALPFYFRFLPNYLL	WBP1L	91	Q9NX94
YFRFLPNYLLPPYEE	WBP1L	96	Q9NX94
NPLRCPVKFYEFYLS	ZMYM3	1291	Q14202
DYFIPFLPLEYRHVK	TOR1B	271	O14657
PQLLAYRCIYKPEFF	TM6SF1	346	Q9BZW5
YLPFPIIQQYKFLRF	NDC1	191	Q9BTX1