Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	FerI	MYOF OTOF	1.58e-04	5	75	2	SM01202
Domain	FerB	MYOF OTOF	1.58e-04	5	75	2	SM01201
Domain	Ferlin_B-domain	MYOF OTOF	1.58e-04	5	75	2	IPR012561
Domain	Ferlin_C	MYOF OTOF	1.58e-04	5	75	2	PF16165
Domain	Ferlin_C	MYOF OTOF	1.58e-04	5	75	2	IPR032362
Domain	FerIin_dom	MYOF OTOF	1.58e-04	5	75	2	IPR012968
Domain	FerI	MYOF OTOF	1.58e-04	5	75	2	PF08151
Domain	FerB	MYOF OTOF	1.58e-04	5	75	2	PF08150
Domain	DUF1669	FAM83C FAM83H	4.39e-04	8	75	2	IPR012461
Domain	DUF1669	FAM83C FAM83H	4.39e-04	8	75	2	PF07894
Domain	Znf_CXXC	KDM2B CXXC1	8.55e-04	11	75	2	IPR002857
Domain	ZF_CXXC	KDM2B CXXC1	8.55e-04	11	75	2	PS51058
Domain	zf-CXXC	KDM2B CXXC1	8.55e-04	11	75	2	PF02008
Domain	C2	DAB2IP MYOF MCTP1 OTOF	1.91e-03	131	75	4	PF00168
Domain	C2	DAB2IP MYOF MCTP1 OTOF	2.25e-03	137	75	4	SM00239
Domain	C2	DAB2IP MYOF MCTP1 OTOF	2.56e-03	142	75	4	PS50004
Domain	-	DAB2IP MYOF MCTP1 OTOF	2.98e-03	148	75	4	2.60.40.150
Domain	Znf_PHD-finger	KDM2B CHD3 CXXC1	3.95e-03	79	75	3	IPR019787
Domain	C2_dom	DAB2IP MYOF MCTP1 OTOF	4.29e-03	164	75	4	IPR000008
Domain	PHD	KDM2B CHD3 CXXC1	5.52e-03	89	75	3	SM00249
Domain	Znf_PHD	KDM2B CHD3 CXXC1	5.87e-03	91	75	3	IPR001965
Domain	ZF_PHD_2	KDM2B CHD3 CXXC1	6.61e-03	95	75	3	PS50016
Domain	ZF_PHD_1	KDM2B CHD3 CXXC1	6.80e-03	96	75	3	PS01359
Domain	-	KDM2B RNF40 CHD3 ZNF598 CXXC1 RNF26	9.31e-03	449	75	6	3.30.40.10
Domain	Znf_RING/FYVE/PHD	KDM2B RNF40 CHD3 ZNF598 CXXC1 RNF26	1.03e-02	459	75	6	IPR013083
Pubmed	Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element.	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	4.91e-19	12	86	8	10433963
Pubmed	Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy.	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	1.27e-18	13	86	8	17668377
Pubmed	The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	3.52e-18	8	86	7	17588759
Pubmed	DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	5.25e-17	10	86	7	17984056
Pubmed	Characterization of a tandemly repeated 3.3-kb KpnI unit in the facioscapulohumeral muscular dystrophy (FSHD) gene region on chromosome 4q35.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	7.47e-16	13	86	7	7739628
Pubmed	Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	8.39e-15	17	86	7	11245978
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	NFATC2IP WDR33 BCL7C YLPM1 KDM2B RNF40 CHD3 MIDEAS PRRC2B	2.30e-08	268	86	9	33640491
Pubmed	The homeobox transcription factor DUXBL controls exit from totipotency.	DUX4L9 DUX4L2 DUX4L4	5.83e-08	4	86	3	38509386
Pubmed	Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development.	DUX4L9 DUX4L2 DUX4L4	5.83e-08	4	86	3	17911620
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DAB2IP SCAF1 MYOF FAM20C SLC38A10 EPPK1 ARID3A RIPOR1 CACNA1H RNF40 PRKDC MARVELD3 BAHD1 PRRC2B FAM83H	8.17e-08	1105	86	15	35748872
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SCAF1 WDR33 TAF1C YLPM1 KDM2B ZFR RNF40 CHD3 TAF15 PRKDC XRCC1 MIDEAS TTN CXXC1 HDGFL2 SF1	1.02e-07	1294	86	16	30804502
Pubmed	Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl.	DUX4L9 DUX4L2 DUX4L4	1.45e-07	5	86	3	20063414
Pubmed	The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.	DUX4L9 DUX4L2 DUX4L4	5.07e-07	7	86	3	30765463
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	YLPM1 ZFR CHD3 TAF15 PRKDC XRCC1 HDGFL2 SF1	5.34e-07	283	86	8	30585729
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	MYOF WDR33 ZFR TAF15 PRKDC XRCC1 ZNF598 MIDEAS	2.10e-06	340	86	8	24332808
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SCAF1 MYOF PRICKLE3 BCL7C YLPM1 KDM2B RIPOR1 CHD3 PRKDC PATL1 SF1	3.32e-06	774	86	11	15302935
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	SLC35F3 WDR33 YLPM1 ZFR CHD3 TAF15 RP9 PRKDC XRCC1 MIDEAS HDGFL2 SF1	4.02e-06	954	86	12	36373674
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	EPPK1 WDR33 YLPM1 ZFR TAF15 RP9 PRKDC PATL1 ZNF598 SF1 PRRC2B	4.93e-06	807	86	11	22681889
Pubmed	Ferlin Overview: From Membrane to Cancer Biology.	MYOF OTOF	6.04e-06	2	86	2	31443490
Pubmed	Association between polymorphisms in DNA repair genes (XRCC1 and XRCC7) and risk of preeclampsia.	PRKDC XRCC1	6.04e-06	2	86	2	22825692
Pubmed	Defective regulation of microRNA target genes in myoblasts from facioscapulohumeral dystrophy patients.	DUX4L9 DUX4	6.04e-06	2	86	2	24145033
Pubmed	XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage.	PRKDC XRCC1	6.04e-06	2	86	2	16397295
Pubmed	Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice.	DUX4L9 DUX4L2 DUX4L4	6.50e-06	15	86	3	35727972
Pubmed	Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins.	DUX4L9 DUX4L2 DUX4L4	6.50e-06	15	86	3	30071041
Pubmed	FerA is a Membrane-Associating Four-Helix Bundle Domain in the Ferlin Family of Membrane-Fusion Proteins.	MYOF OTOF	1.81e-05	3	86	2	30026467
Pubmed	Cxxc finger protein 1 maintains homeostasis and function of intestinal group 3 innate lymphoid cells with aging.	PRKDC CXXC1	1.81e-05	3	86	2	37429951
Pubmed	Polymorphisms of DNA repair genes are risk factors for prostate cancer.	PRKDC XRCC1	1.81e-05	3	86	2	17196815
Pubmed	DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair.	PRKDC XRCC1	1.81e-05	3	86	2	26603896
Pubmed	The C2 domains of otoferlin, dysferlin, and myoferlin alter the packing of lipid bilayers.	MYOF OTOF	1.81e-05	3	86	2	23859474
Pubmed	Genetic variations in DNA-repair genes (XRCC1, 3, and 7) and the susceptibility to hepatocellular carcinoma in a cohort of Egyptians.	PRKDC XRCC1	1.81e-05	3	86	2	32281666
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ARID3A PRICKLE3 DUX4L9 ZFR DUX4L2 CHD3 ZNF598 DUX4L4 CXXC1 SF1	3.12e-05	808	86	10	20412781
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	YLPM1 ZFR MIDEAS HDGFL2 SF1	3.44e-05	148	86	5	32538781
Pubmed	DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation.	DUX4L9 DUX4	3.61e-05	4	86	2	19829708
Pubmed	Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.	PRKDC XRCC1	3.61e-05	4	86	2	19851285
Pubmed	The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.	TAF15 SF1	3.61e-05	4	86	2	9660765
Pubmed	PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro.	PRKDC XRCC1	3.61e-05	4	86	2	18678286
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	SCAF1 EPPK1 YLPM1 ZFR CHD3 TAF15 PRKDC XRCC1 TTN SF1 FAM83H	4.46e-05	1024	86	11	24711643
Pubmed	Human transcription factor protein interaction networks.	ARID3A WDR33 BCL7C YLPM1 KDM2B ZFR CHD3 PATL1 XRCC1 MIDEAS TTN CXXC1 PRRC2B	4.81e-05	1429	86	13	35140242
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	ARID3A KDM2B CHD3 MIDEAS	5.52e-05	83	86	4	28794006
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	EPPK1 WDR33 ZFR CHD3 PRKDC XRCC1 MIDEAS	5.66e-05	394	86	7	27248496
Pubmed	Polymorphisms of DNA repair genes and risk of glioma.	PRKDC XRCC1	6.01e-05	5	86	2	15313891
Pubmed	RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy.	DUX4L2 DUX4	6.01e-05	5	86	2	19359275
Pubmed	Polymorphisms of DNA repair genes are associated with renal cell carcinoma.	PRKDC XRCC1	6.01e-05	5	86	2	16510122
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	WDR33 YLPM1 ZFR TAF15 HDGFL2 SF1 PNP	6.12e-05	399	86	7	35987950
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	WDR33 YLPM1 KDM2B ZFR PRKDC ZNF598 MIDEAS PRRC2B	6.61e-05	549	86	8	38280479
Pubmed	The functional interactome landscape of the human histone deacetylase family.	WDR33 YLPM1 ZFR CHD3 PRKDC MIDEAS	8.42e-05	289	86	6	23752268
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	SCAF1 FAM20C SLC38A10 KCNJ9 PRKDC MTCL1 ZNF831 CXXC1 SF1	8.73e-05	736	86	9	29676528
Pubmed	M-CSF mediates TNF-induced inflammatory osteolysis.	CSF1 PRKDC	9.01e-05	6	86	2	16294221
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	EPPK1 KIF27 WDR33 BCL7C YLPM1 CHD3 PRKDC MTCL1	9.90e-05	582	86	8	20467437
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	TSPOAP1 MRC2 RNF40 HEPH	1.23e-04	102	86	4	9734811
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ARID3A NFATC2IP BCL7C KDM2B CHD3 XRCC1 MIDEAS HDGFL2	1.34e-04	608	86	8	36089195
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	WDR33 YLPM1 ZFR RP9 MIDEAS PRRC2B FAM83H	1.42e-04	457	86	7	32344865
Pubmed	Macrophages driven to a novel state of activation have anti-inflammatory properties in mice.	CSF1 PRKDC	1.68e-04	8	86	2	18097035
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	MYOF EPPK1 CHD3 PRKDC MTCL1 PRRC2B	1.79e-04	332	86	6	37433992
Pubmed	EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.	YLPM1 KDM2B ZFR	1.80e-04	44	86	3	27505670
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	WDR33 YLPM1 CHD3 XRCC1 MIDEAS SF1	2.07e-04	341	86	6	32971831
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	SLC35F3 NFATC2IP ELFN1 CHD3 TAF15 COL25A1 LMTK3 SMOX CXXC1 BAHD1	2.14e-04	1021	86	10	26760575
Pubmed	Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair.	RNF40 CHD3	2.15e-04	9	86	2	25533843
Pubmed	Pellino1 specifically binds to phospho-Thr18 of p53 and is recruited to sites of DNA damage.	PRKDC XRCC1	2.15e-04	9	86	2	30987826
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	YLPM1 ZFR CHD3 TAF15 RP9 PRKDC MIDEAS PRRC2B	2.21e-04	655	86	8	35819319
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	YLPM1 ZFR RNF40 PRKDC MIDEAS	2.22e-04	220	86	5	35785414
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	DUX4L9 DUX4L2 DUX4L4	2.63e-04	50	86	3	31806660
Pubmed	Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening.	PRKDC LMTK3	2.68e-04	10	86	2	25495526
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	MYOF KIF27 PRKDC SOWAHC SF1	3.01e-04	235	86	5	28378594
Pubmed	The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms.	FAM83C FAM83H	3.28e-04	11	86	2	29789297
Pubmed	Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.	KDM2B PRKDC	3.28e-04	11	86	2	26237645
Pubmed	Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.	SCAF1 CHD3 HDGFL2	3.68e-04	56	86	3	26919559
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SCAF1 ZFR PRKDC CXXC1 HDGFL2	4.07e-04	251	86	5	31076518
Pubmed	A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.	WDR33 ZFR TAF15 PATL1 SF1	4.30e-04	254	86	5	28431233
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	MYOF TAF1C YLPM1 ZFR PATL1 ZNF598 SF1 PRRC2B	4.32e-04	724	86	8	36232890
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	MYOF EPPK1 CHD3 PRKDC SF1	4.45e-04	256	86	5	33397691
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	YLPM1 ZFR CHD3 TAF15 PRKDC ZNF598 HDGFL2 SF1 PRRC2B	5.07e-04	934	86	9	33916271
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DAB2IP TSPOAP1 RIPOR1 CACNA1H MTCL1 PRRC2B	5.29e-04	407	86	6	12693553
Pubmed	UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1.	PRKDC XRCC1	5.39e-04	14	86	2	34111398
Pubmed	Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.	PRICKLE3 MAGIX	5.39e-04	14	86	2	11138001
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	DUS2 SCAF1 WDR33 TAF1C YLPM1 CHD3 TAF15 PATL1 MIDEAS SF1 PRRC2B	5.59e-04	1371	86	11	36244648
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	WDR33 MIDEAS SF1 PRRC2B	5.64e-04	152	86	4	38360978
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	PRICKLE3 YLPM1 ZFR TAF15 PRKDC MTCL1 PATL1 TTN PRRC2B FAM83H	5.65e-04	1155	86	10	20360068
Pubmed	Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.	PRKDC XRCC1	6.21e-04	15	86	2	19661379
Pubmed	DUSP2 recruits CSNK2A1 to suppress AKT1-mediated apoptosis resistance under hypoxic microenvironment in pancreatic cancer.	RNF40 ZNF598	6.21e-04	15	86	2	37390887
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	EPPK1 TSPOAP1 YLPM1 ZFR LMTK3 TTN	7.05e-04	430	86	6	35044719
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	WDR33 YLPM1 ZFR CHD3 TAF15 PRKDC PTPN21 TTN CXXC1 HDGFL2 PRRC2B	8.46e-04	1442	86	11	35575683
Pubmed	RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells.	RNF40 CXXC1	9.01e-04	18	86	2	19410543
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	YLPM1 ZFR RNF40 CHD3 TAF15 PRKDC XRCC1 HDGFL2 SF1	9.08e-04	1014	86	9	32416067
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	FAM20C MRC2 YLPM1 ZNF598 FAM83H	9.37e-04	302	86	5	30561431
Pubmed	TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT-GSK-3β-β-Catenin Signaling Pathway.	MYOF EPPK1 KIF27 PRKDC FAM83H	9.79e-04	305	86	5	33194618
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	YLPM1 ZFR RNF40 CHD3 TAF15 PRKDC PATL1	1.19e-03	653	86	7	33742100
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	EPPK1 YLPM1 ZFR TAF15 PRKDC PRRC2B PNP	1.19e-03	653	86	7	22586326
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	MYOF YLPM1 ZFR PRKDC XRCC1 HDGFL2 SF1	1.26e-03	660	86	7	32780723
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	MAGIX ZFR CFAP70 MIDEAS CXXC1 SF1	1.47e-03	496	86	6	31343991
Pubmed	BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility.	KDM2B PRRC2B	1.61e-03	24	86	2	33722704
Pubmed	The HMGB1-2 Ovarian Cancer Interactome. The Role of HMGB Proteins and Their Interacting Partners MIEN1 and NOP53 in Ovary Cancer and Drug-Response.	ZFR ZNF428	1.61e-03	24	86	2	32867128
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	ARID3A ZFR CHD3 PRKDC XRCC1 MIDEAS SF1 PRRC2B PNP	1.62e-03	1103	86	9	34189442
Pubmed	Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.	PRKDC XRCC1	1.75e-03	25	86	2	15385968
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SCAF1 MCTP1 SLC35F3 TAF1C BCL7C CHD3 SOWAHC PRRC2B FAM83H	1.76e-03	1116	86	9	31753913
Pubmed	Interaction network of human early embryonic transcription factors.	ARID3A BCL7C KDM2B MIDEAS PRRC2B	1.82e-03	351	86	5	38297188
Pubmed	Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.	PRKDC XRCC1	2.04e-03	27	86	2	20610542
Pubmed	Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.	CACNA1H ZNF598	2.04e-03	27	86	2	19026994
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	SCAF1 OTOF PRKDC MTCL1 PRRC2B	2.05e-03	361	86	5	26167880
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	WDR33 YLPM1 PATL1 ZNF598	2.21e-03	220	86	4	24550385
Interaction	TOP3B interactions	DAB2IP SCAF1 MYOF FAM20C SLC38A10 EPPK1 ARID3A APBA1 RIPOR1 ZFR CACNA1H RNF40 TAF15 PRKDC PATL1 MARVELD3 ZNF598 BAHD1 PRRC2B FAM83H	5.27e-07	1470	78	20	int:TOP3B
Interaction	SP7 interactions	ARID3A WDR33 BCL7C YLPM1 KDM2B ZFR CHD3 MIDEAS PRRC2B	2.63e-06	304	78	9	int:SP7
Cytoband	4q35.2	DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	1.04e-11	27	86	6	4q35.2
Cytoband	Ensembl 112 genes in cytogenetic band chr4q35	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	6.27e-11	117	86	8	chr4q35
Cytoband	9q34.13	PLPP7 PRRC2B	7.12e-04	21	86	2	9q34.13
Cytoband	7p22.3	FAM20C ELFN1	1.87e-03	34	86	2	7p22.3
Cytoband	Ensembl 112 genes in cytogenetic band chr16p11	NPIPB13 NFATC2IP BCL7C RNF40	1.89e-03	278	86	4	chr16p11
Cytoband	17q21.33	RSAD1 NXPH3	2.71e-03	41	86	2	17q21.33
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	C9orf50 NPDC1 PLPP7 PRRC2B	3.32e-03	325	86	4	chr9q34
Cytoband	Ensembl 112 genes in cytogenetic band chr16q22	DUS2 RIPOR1 MARVELD3	5.00e-03	183	86	3	chr16q22
GeneFamily	PRD class homeoboxes and pseudogenes	DUX4L9 DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	3.73e-09	92	47	7	521
GeneFamily	Ferlin family	MYOF OTOF	9.86e-05	6	47	2	828
GeneFamily	Zinc fingers CXXC-type	KDM2B CXXC1	4.29e-04	12	47	2	136
GeneFamily	PHD finger proteins	KDM2B CHD3 CXXC1	1.65e-03	90	47	3	88
GeneFamily	PDZ domain containing	MAGIX APBA1 SHROOM2	7.21e-03	152	47	3	1220
GeneFamily	Fibronectin type III domain containing	TSPOAP1 ELFN1 TTN	8.29e-03	160	47	3	555
Coexpression	DESCARTES_ORGANOGENESIS_NEURAL_PROGENITOR_CELLS	ELFN1 VXN MTCL1 MAPK4	1.93e-05	50	83	4	MM3639
Coexpression	BLANCO_MELO_INFLUENZA_A_INFECTION_A594_CELLS_DN	FAM20C SLC38A10 MRC2 ZNF428 BAHD1	3.73e-05	118	83	5	M34005
Coexpression	GSE41176_UNSTIM_VS_ANTI_IGM_STIM_TAK1_KO_BCELL_3H_UP	SRRD DUS2 SLC35F3 APBA1 C9orf50 ZFR	4.01e-05	198	83	6	M9929
Coexpression	GSE17721_LPS_VS_PAM3CSK4_1H_BMDC_DN	FAM20C WDR33 TAF1C CACNA1H ZNF598 SOWAHC	4.12e-05	199	83	6	M3912
Drug	Nalbuphine hydrochloride [23277-43-2]; Up 200; 10.2uM; HL60; HG-U133A	DUS2 RSAD1 MRC2 TAF1C BCL7C YLPM1 NXPH3 PRRC2B	6.51e-07	196	84	8	1379_UP
Drug	Ethotoin [86-35-1]; Down 200; 19.6uM; MCF7; HT_HG-U133A	MYOF WDR33 CSPG5 RIPOR1 CACNA1H ZNF428 PTPN21	8.14e-06	196	84	7	3892_DN
Drug	Piroxicam [36322-90-4]; Down 200; 12uM; PC3; HT_HG-U133A	DUS2 MYOF PRICKLE3 TAF1C CHD3 XRCC1 BAHD1	8.14e-06	196	84	7	2089_DN
Drug	Pheniramine maleate [132-20-7]; Up 200; 11.2uM; PC3; HG-U133A	DUS2 BCL7C YLPM1 ZFR RNF40 NXPH3 PRRC2B	8.70e-06	198	84	7	1910_UP
Disease	limb-girdle muscular dystrophy (implicated_via_orthology)	MYOF OTOF	1.44e-04	7	78	2	DOID:11724 (implicated_via_orthology)
Disease	metabolite measurement	MYOF VXN YLPM1 MARVELD3 SMOX SHROOM2 PNP	7.05e-04	560	78	7	EFO_0004725
Disease	response to hydrochlorothiazide, systolic blood pressure change measurement	UBXN2B TAF1C	8.08e-04	16	78	2	EFO_0005202, EFO_0006944
Disease	coffee consumption	YLPM1 CXXC1	3.25e-03	32	78	2	EFO_0004330
Disease	Squamous cell carcinoma of lung	PRKDC TTN	3.25e-03	32	78	2	C0149782

Protein segments in the cluster

Peptide	Gene	Start	Entry
AQGPSSRGREPEARP	RNF40	596	O75150
SRESAPRQPGPGERE	C9orf50	111	Q5SZB4
GDPPERRDCELGRPG	ELFN1	531	P0C7U0
PRPGEPGRDLASSEN	CSPG5	341	O95196
PHPGKSREDRDPQRD	DUX4L4	261	P0CJ87
SREDRDPQRDGLPGP	DUX4L4	266	P0CJ87
PHPGKSREDRDPQRD	DUX4L6	261	P0CJ89
SREDRDPQRDGLPGP	DUX4L6	266	P0CJ89
EPRPEDSRPSGGDFR	TAF15	381	Q92804
PEAGGLDREPRTPQA	TSPOAP1	1831	O95153
PGVAEDVRGRSPPER	MTCL1	296	Q9Y4B5
AAFSPGQEEPPRRRG	KCNJ9	6	Q92806
DEGLGPDPPHRDRLR	DAB2IP	1016	Q5VWQ8
QRPPQGPEDDRDLSE	PATL1	156	Q86TB9
QPPPRGDRARDEGAR	MCTP1	171	Q6DN14
ERRAEDPNDQIPGSP	MAGIX	286	Q9H6Y5
PHPGKSREDRDPQRD	DUX4	261	Q9UBX2
SREDRDPQRDGLPGP	DUX4	266	Q9UBX2
ADDPERRLSASPPGR	MAPK4	511	P31152
NGGLRFPRNTERPPE	LMTK3	1006	Q96Q04
PHPGKSREDRDPQRD	DUX4L3	261	P0CJ86
SREDRDPQRDGLPGP	DUX4L3	266	P0CJ86
NCGDGPDARIPERRP	KIF27	566	Q86VH2
GGREPRSEDPTPAEQ	COL25A1	11	Q9BXS0
DRPRQPAPGDGSKER	FAM169B	141	Q8N8A8
PRGTDVREPDDSPQG	MRC2	811	Q9UBG0
VREGPDLDRPGSDRQ	HDGFL2	641	Q7Z4V5
EESGARAPPARAREP	PTPN21	721	Q16825
PGGGRPQPRLEDEID	NPDC1	86	Q9NQX5
NPPRVREPTGREAFG	PANK2	56	Q9BZ23
SGRAPPEAEDPDRGQ	PRICKLE3	11	O43900
AALRDRPPPRFEDTG	PGBD5	96	Q8N414
EGGPRDESRDEPPIR	ATP11AUN	41	Q6ZP68
RPVPDPDLQRRAGSG	CXXC1	111	Q9P0U4
DEEGEGRDRAPKPPT	KDM2B	426	Q8NHM5
EEAQPPRLGQERDPG	BCL7C	136	Q8WUZ0
TRDRRSPAEPEGGPA	CSF1	446	P09603
SGPLRPGEQAPEDRR	FAM83C	531	Q9BQN1
PPAAEPAERALRGRD	FAM20C	111	Q8IXL6
PGPRDEPRSNGRREE	CHD3	1686	Q12873
DIDGRPRPGDVQAPS	CFAP70	421	Q5T0N1
PHPGKSREDRDPQRD	DUX4L9	261	Q6RFH8
SREDRDPQRDGLPGP	DUX4L9	266	Q6RFH8
RDLSPEPAPDEGPRR	BAHD1	181	Q8TBE0
AEQDLERPPTPAGGR	APBA1	296	Q02410
PHPGKSREDRDPQRD	DUX4L7	261	P0CJ90
SREDRDPQRDGLPGP	DUX4L7	266	P0CJ90
EVGRGRREPAPAQPE	EID2	26	Q8N6I1
RREPAPAQPEEAGEG	EID2	31	Q8N6I1
EEPVPRERDRDPCGG	LURAP1L	31	Q8IV03
ERDPGRRPHPDQGRT	MARVELD3	16	Q96A59
PDGERLAPNGREREA	MIDEAS	411	Q6PJG2
RKREAPDQDPGGPRA	DUS2	451	Q9NX74
PHPGKSREDRDPQRD	DUX4L5	261	P0CJ88
SREDRDPQRDGLPGP	DUX4L5	266	P0CJ88
APEAEPERRGGPEGR	FAM83H	561	Q6ZRV2
QGPGSARRVDADRPP	CACNA1H	1886	O95180
DEEGSDPPLPGRAQR	C7orf50	171	Q9BRJ6
PPEPREQRDVERAGG	SLC38A10	666	Q9HBR0
PDPAREAGGPEERLA	SLC38A10	861	Q9HBR0
PLRGPNDERFGDRFP	PNP	146	P00491
GNEVDGLSRPQRPRP	OTOF	641	Q9HC10
GERLRGPLPPSADDN	NPIPB13	746	A6NJU9
EDPERDDHEGQPRPR	NXPH3	31	O95157
RRRVENAGGSPSPEP	RSAD1	21	Q9HA92
GAAGARRPREPPEQE	RP9	11	Q8TA86
SLRRDAGPPGDTQPD	TAF1C	606	Q15572
DGTFRIPRPRTGPEE	HEPH	791	Q9BQS7
RAEAEAGSPRPDPRE	EPPK1	2501	P58107
ARAEAEAGSPRPDPR	EPPK1	3036	P58107
EAGSPRPDPREALRA	EPPK1	3041	P58107
AEAGSPRPDPREALR	EPPK1	3571	P58107
ARAEAEAGSPRPDPR	EPPK1	4101	P58107
EAGSPRPDPREALRA	EPPK1	4106	P58107
AEAGSPRPDPREALR	EPPK1	4641	P58107
RGRERLNEEEPPGGQ	RNF26	351	Q9BY78
GDPGEPREELPSAVR	SHROOM2	941	Q13796
PSFRDPEQPLEGRGE	SOWAHC	486	Q53LP3
DSEGEDRRPAGPPRE	NFATC2IP	91	Q8NCF5
GEERPRDSPGPAEAQ	SLC35F3	26	Q8IY50
PGRARAAPDEDREPE	ARID3A	36	Q99856
EEPPRAGEGRPAGRE	ZNF428	136	Q96B54
LL, NOT REPRESE	TTN	36	Q8WZ42
EGPERPQDTPLGDSR	TEX13D	561	A0A0J9YY54
GPEPGEQERRSSGPR	UBXN2B	6	Q14CS0
GPRPGSPGDAEDRRE	TRPM5	6	Q9NZQ8
EDRGDGPPDRDPTLS	SCAF1	16	Q9H7N4
ARPRGPEIEPRGEGD	SMOX	271	Q9NWM0
RRERREGPGSEPDSQ	PRRC2B	1386	Q5JSZ5
PRGREAAPRGPEAEF	SRRD	41	Q9UH36
SPRGPRFDGPRRFED	YLPM1	756	P49750
RSLGPPQGEEDSVPR	PRKDC	2106	P78527
EEAAARGPEDPRGPR	ZNF598	376	Q86UK7
QGPAPLRRPDSSDDR	ZFR	711	Q96KR1
ELLPHRGDRRDPGDR	VXN	56	Q8TAG6
GEGTEPRRPRAGPEE	XRCC1	301	P18887
RPGDERFPRDPEDPR	WDR33	1081	Q9C0J8
GEPPRPEGRGESRCQ	ZNF831	221	Q5JPB2
RRPETPSSGPLDEEG	RIPOR1	421	Q6ZS17
RTGDLGIPPNPEDRS	SF1	66	Q15637
SAQPPPAGDGARERR	PLPP7	46	Q8NBV4
PHPGKSREDRDPQRD	DUX4L2	261	P0CJ85
SREDRDPQRDGLPGP	DUX4L2	266	P0CJ85
LRNEREAPGTPRAPG	KIAA1522	176	Q9P206
FVLGTGDEPPPERRD	MYOF	321	Q9NZM1
GDEPPPERRDRDNDS	MYOF	326	Q9NZM1