Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium ion binding	SCN1A SCN2A SCN3A SCN8A	1.11e-06	14	118	4	GO:0031402
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN1A SCN2A SCN3A SCN8A	1.57e-05	26	118	4	GO:0005248
GeneOntologyMolecularFunction	alkali metal ion binding	SCN1A SCN2A SCN3A SCN8A	1.57e-05	26	118	4	GO:0031420
GeneOntologyMolecularFunction	medium-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	3.46e-05	2	118	2	GO:0140981
GeneOntologyMolecularFunction	16-hydroxypalmitate dehydrogenase activity	CYP4A11 CYP4A22	3.46e-05	2	118	2	GO:0103002
GeneOntologyMolecularFunction	cholesterol-protein transferase activity	SHH IHH	1.03e-04	3	118	2	GO:0140853
GeneOntologyMolecularFunction	sodium channel activity	SCN1A SCN2A SCN3A SCN8A	2.52e-04	52	118	4	GO:0005272
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	GRIN2B SLC40A1 KCNH3 SCN1A SCN2A SCN3A SCN8A TRPV4 ATP2B1 ATP2B3	4.41e-04	465	118	10	GO:0046873
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCA3 ABCA4 ATP2B1 ATP2B3 ABCG5	4.74e-04	109	118	5	GO:0042626
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4A11 CYP4A22	7.13e-04	7	118	2	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4A11 CYP4A22	7.13e-04	7	118	2	GO:0018685
GeneOntologyMolecularFunction	patched binding	SHH IHH	9.47e-04	8	118	2	GO:0005113
GeneOntologyMolecularFunction	ATP-dependent activity	ABCA3 ABCA4 ZGRF1 MSH5 ACSL1 MDN1 RECQL5 ATP2B1 ATP2B3 ABCG5 SMC1B	1.04e-03	614	118	11	GO:0140657
GeneOntologyMolecularFunction	cell-matrix adhesion mediator activity	ITGA1 SVEP1	1.21e-03	9	118	2	GO:0098634
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	GRIN2B SLC40A1 KCNH3 SLC15A1 SCN1A SCN2A SCN3A SCN8A TRPV4 ATP2B1 ATP2B3	1.23e-03	627	118	11	GO:0022890
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4A11 CYP4A22	1.51e-03	10	118	2	GO:0052869
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	1.51e-03	10	118	2	GO:0120250
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	1.51e-03	10	118	2	GO:0102033
GeneOntologyBiologicalProcess	membrane depolarization	CAMK2D PPIF SCN1A SCN2A SCN3A SCN8A FHL1	5.21e-06	121	115	7	GO:0051899
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN1A SCN2A SCN3A SCN8A	4.71e-05	36	115	4	GO:0086010
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	CAMK2D PTPN22 GRIN2B SLC40A1 KCNH3 PPIF SLC15A1 SCN1A SCN2A SCN3A SCN8A TRPV4 NR3C2 FHL1 ATP2B1 ATP2B3	5.26e-05	922	115	16	GO:0098662
GeneOntologyBiologicalProcess	blood circulation	CAMK2D ITGA1 SVEP1 SCN1A SCN2A SCN3A SCN8A CMA1 TRPV4 NR3C2 SMPD3 ATP2B1 ATP2B3	6.66e-05	648	115	13	GO:0008015
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	CAMK2D PTPN22 GRIN2B SLC40A1 KCNH3 PPIF SLC15A1 SCN1A SCN2A SCN3A SCN8A TRPV4 NR3C2 FHL1 ATP2B1 ATP2B3	6.78e-05	942	115	16	GO:0098655
GeneOntologyBiologicalProcess	monoatomic ion transport	EPHB2 CAMK2D HBP1 PTPN22 GRIN2B SLC40A1 KCNH3 PPIF TG SLC15A1 SCN1A SCN2A SCN3A SCN8A TRPV4 NR3C2 LTF FHL1 ATP2B1 ATP2B3	6.80e-05	1374	115	20	GO:0006811
GeneOntologyBiologicalProcess	monoatomic cation transport	CAMK2D HBP1 PTPN22 GRIN2B SLC40A1 KCNH3 PPIF SLC15A1 SCN1A SCN2A SCN3A SCN8A TRPV4 NR3C2 LTF FHL1 ATP2B1 ATP2B3	7.12e-05	1157	115	18	GO:0006812
GeneOntologyBiologicalProcess	skeletal muscle fiber differentiation	HDAC9 SHH PPIF	8.97e-05	16	115	3	GO:0098528
GeneOntologyBiologicalProcess	lauric acid metabolic process	CYP4A11 CYP4A22	9.21e-05	3	115	2	GO:0048252
GeneOntologyBiologicalProcess	protein splicing	SHH IHH	9.21e-05	3	115	2	GO:0030908
GeneOntologyBiologicalProcess	intein-mediated protein splicing	SHH IHH	9.21e-05	3	115	2	GO:0016539
GeneOntologyBiologicalProcess	regulation of immature T cell proliferation in thymus	SHH CD1D IHH	1.08e-04	17	115	3	GO:0033084
GeneOntologyBiologicalProcess	cardiac muscle cell action potential	CAMK2D SCN1A SCN2A SCN3A SCN8A	1.27e-04	87	115	5	GO:0086001
GeneOntologyBiologicalProcess	regulation of immature T cell proliferation	SHH CD1D IHH	1.30e-04	18	115	3	GO:0033083
GeneOntologyBiologicalProcess	metal ion transport	CAMK2D HBP1 PTPN22 GRIN2B SLC40A1 KCNH3 SCN1A SCN2A SCN3A SCN8A TRPV4 NR3C2 LTF FHL1 ATP2B1 ATP2B3	1.36e-04	1000	115	16	GO:0030001
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	EPHB2 CAMK2D PTPN22 GRIN2B SLC40A1 KCNH3 PPIF SLC15A1 SCN1A SCN2A SCN3A SCN8A TRPV4 NR3C2 FHL1 ATP2B1 ATP2B3	1.47e-04	1115	115	17	GO:0034220
GeneOntologyBiologicalProcess	immature T cell proliferation in thymus	SHH CD1D IHH	1.53e-04	19	115	3	GO:0033080
GeneOntologyBiologicalProcess	cell adhesion mediated by integrin	ITGA1 RET EPHA2 HRG PLAU	1.57e-04	91	115	5	GO:0033627
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	CAMK2D PTPN22 GRIN2B SLC40A1 KCNH3 PPIF SLC15A1 SCN1A SCN2A SCN3A SCN8A TRPV4 NR3C2 FHL1 ATP2B1 ATP2B3	1.65e-04	1017	115	16	GO:0098660
GeneOntologyBiologicalProcess	regulation of cell adhesion mediated by integrin	RET EPHA2 HRG PLAU	1.73e-04	50	115	4	GO:0033628
GeneOntologyBiologicalProcess	cardiac muscle cell contraction	CAMK2D SCN1A SCN2A SCN3A SCN8A	1.74e-04	93	115	5	GO:0086003
GeneOntologyBiologicalProcess	negative regulation of immunoglobulin production	SIGLEC16 SIGLEC11 PRKDC	1.80e-04	20	115	3	GO:0002638
GeneOntologyBiologicalProcess	immature T cell proliferation	SHH CD1D IHH	1.80e-04	20	115	3	GO:0033079
GeneOntologyBiologicalProcess	regulation of immunoglobulin production	EPHB2 SIGLEC16 SUPT6H SIGLEC11 PRKDC	1.92e-04	95	115	5	GO:0002637
GeneOntologyBiologicalProcess	circulatory system process	CAMK2D ITGA1 SVEP1 SCN1A SCN2A SCN3A SCN8A CMA1 TRPV4 NR3C2 SMPD3 ATP2B1 ATP2B3	2.26e-04	733	115	13	GO:0003013
GeneOntologyBiologicalProcess	determination of adult lifespan	HDAC9 POLG SCN1A SCN2A	2.34e-04	54	115	4	GO:0008340
GeneOntologyBiologicalProcess	regulation of membrane potential	CAMK2D GRIN2B KCNH3 PPIF SCN1A SCN2A SCN3A SCN8A NR3C2 LTF FHL1	2.94e-04	559	115	11	GO:0042391
GeneOntologyBiologicalProcess	DNA metabolic process	HDAC9 UBR2 ZGRF1 CAMK2D POLG MSH5 TEX15 MAP3K4 PARP4 PPP5C SUPT6H N4BP2 RECQL5 PRKDC SMPD3 HERC2	3.27e-04	1081	115	16	GO:0006259
GeneOntologyBiologicalProcess	nerve development	EPHB2 RET SCN1A SCN2A SCN8A	3.64e-04	109	115	5	GO:0021675
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	SCN1A SCN2A SCN3A SCN8A	3.99e-04	62	115	4	GO:0086002
GeneOntologyBiologicalProcess	neuronal action potential	SCN1A SCN2A SCN3A SCN8A	4.24e-04	63	115	4	GO:0019228
GeneOntologyCellularComponent	axon initial segment	CAMK2D ADAM22 SCN1A SCN2A SCN8A	5.61e-07	29	118	5	GO:0043194
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN1A SCN2A SCN3A SCN8A	2.17e-06	17	118	4	GO:0001518
GeneOntologyCellularComponent	sodium channel complex	SCN1A SCN2A SCN3A SCN8A	2.05e-05	29	118	4	GO:0034706
GeneOntologyCellularComponent	mucus layer	MUC2 MUC5AC	9.44e-05	3	118	2	GO:0070701
GeneOntologyCellularComponent	main axon	CAMK2D ADAM22 SCN1A SCN2A SCN8A	1.50e-04	89	118	5	GO:0044304
GeneOntologyCellularComponent	node of Ranvier	SCN1A SCN2A SCN8A	1.86e-04	20	118	3	GO:0033268
GeneOntologyCellularComponent	secretory vesicle	ABCA3 CTTNBP2 GALNS STXBP5L SHH NHLRC2 ITGA1 GRIN2B SLC40A1 GLA AGL ADGRE3 CMA1 HRG PLAU LTF ATP2B1	6.25e-04	1246	118	17	GO:0099503
GeneOntologyCellularComponent	glutamatergic synapse	EPHB2 CTTNBP2 AGO2 MARK1 GRIN2B ADAM22 IL1RAPL2 SCN2A SCN8A NR3C2 TACC3 ATP2B1 ATP2B3	7.15e-04	817	118	13	GO:0098978
GeneOntologyCellularComponent	presynaptic membrane	EPHB2 GRIN2B SCN1A SCN2A SCN8A ATP2B1 ATP2B3	1.00e-03	277	118	7	GO:0042734
MousePheno	abnormal renal sodium reabsorption	CYP4A11 CYP4A22 NR3C2	3.62e-06	5	101	3	MP:0010109
MousePheno	abnormal renal sodium ion transport	CYP4A11 CYP4A22 NR3C2	2.00e-05	8	101	3	MP:0011442
Domain	Na_trans_cytopl	SCN1A SCN2A SCN3A SCN8A	2.10e-08	6	116	4	PF11933
Domain	Na_trans_cytopl	SCN1A SCN2A SCN3A SCN8A	2.10e-08	6	116	4	IPR024583
Domain	Na_channel_asu	SCN1A SCN2A SCN3A SCN8A	2.88e-07	10	116	4	IPR001696
Domain	Na_trans_assoc	SCN1A SCN2A SCN3A SCN8A	2.88e-07	10	116	4	IPR010526
Domain	Na_trans_assoc	SCN1A SCN2A SCN3A SCN8A	2.88e-07	10	116	4	PF06512
Domain	Ephrin_rec_like	EPHB2 SVEP1 TG EPHA2	1.62e-05	25	116	4	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHB2 SVEP1 TG EPHA2	1.62e-05	25	116	4	IPR011641
Domain	Ephrin_rec_like	EPHB2 SVEP1 TG	3.71e-05	11	116	3	PF07699
Domain	-	SRBD1 SUPT6H	3.82e-05	2	116	2	1.10.3500.10
Domain	INTEIN_N_TER	SHH IHH	3.82e-05	2	116	2	PS50817
Domain	-	SRBD1 SUPT6H	3.82e-05	2	116	2	3.30.420.140
Domain	YqgFc	SRBD1 SUPT6H	3.82e-05	2	116	2	SM00732
Domain	Tex-like_dom	SRBD1 SUPT6H	3.82e-05	2	116	2	IPR023323
Domain	Intein_N	SHH IHH	3.82e-05	2	116	2	IPR006141
Domain	YqgF/RNaseH-like_dom	SRBD1 SUPT6H	3.82e-05	2	116	2	IPR006641
Domain	EGF_2	EPHB2 ADAM18 LAMA2 CUBN ADAM22 SVEP1 SUSD1 EPHA2 PLAU	4.13e-05	265	116	9	PS01186
Domain	Growth_fac_rcpt_	EPHB2 TMEM67 CUBN SVEP1 SUSD1 EPHA2 ADGRE3	5.40e-05	156	116	7	IPR009030
Domain	RNaseH-like_dom	AGO2 REXO5 POLG SRBD1 SUPT6H	6.94e-05	69	116	5	IPR012337
Domain	Ion_trans_dom	KCNH3 SCN1A SCN2A SCN3A SCN8A TRPV4	7.79e-05	114	116	6	IPR005821
Domain	Ion_trans	KCNH3 SCN1A SCN2A SCN3A SCN8A TRPV4	7.79e-05	114	116	6	PF00520
Domain	Hedgehog_signalling_dom	SHH IHH	1.14e-04	3	116	2	IPR000320
Domain	HintN	SHH IHH	1.14e-04	3	116	2	SM00306
Domain	HintC	SHH IHH	1.14e-04	3	116	2	SM00305
Domain	Hedgehog	SHH IHH	1.14e-04	3	116	2	IPR001657
Domain	Tex_RuvX-like_dom	SRBD1 SUPT6H	1.14e-04	3	116	2	IPR023097
Domain	HH_signal	SHH IHH	1.14e-04	3	116	2	PF01085
Domain	Hint	SHH IHH	1.14e-04	3	116	2	PF01079
Domain	Hedgehog_sig/DD-Pept_Zn-bd_dom	SHH IHH	1.14e-04	3	116	2	IPR009045
Domain	Hint_dom	SHH IHH	1.14e-04	3	116	2	IPR001767
Domain	-	SRBD1 SUPT6H	1.14e-04	3	116	2	1.10.150.310
Domain	-	SHH IHH	1.14e-04	3	116	2	3.30.1380.10
Domain	Hint_dom_N	SHH IHH	1.14e-04	3	116	2	IPR003587
Domain	Hint_dom_C	SHH IHH	1.14e-04	3	116	2	IPR003586
Domain	EGF-like_dom	ADAM18 LAMA2 CUBN ADAM22 SVEP1 SUSD1 ADGRE3 PLAU	1.64e-04	249	116	8	IPR000742
Domain	EGF-like_CS	ADAM18 LAMA2 CUBN ADAM22 SVEP1 SUSD1 EPHA2 PLAU	2.26e-04	261	116	8	IPR013032
Domain	ATP_Ca_trans_C	ATP2B1 ATP2B3	2.28e-04	4	116	2	IPR022141
Domain	ATP_Ca_trans_C	ATP2B1 ATP2B3	2.28e-04	4	116	2	PF12424
Domain	Hedgehog/Intein_dom	SHH IHH	2.28e-04	4	116	2	IPR028992
Domain	-	SHH IHH	2.28e-04	4	116	2	2.170.16.10
Domain	P-type_ATPase_IIB	ATP2B1 ATP2B3	2.28e-04	4	116	2	IPR006408
Domain	ABC_transporter-like	ABCA3 ABCA4 ABCG5 SMC1B	2.61e-04	50	116	4	IPR003439
Domain	Channel_four-helix_dom	SCN1A SCN2A SCN3A SCN8A	4.33e-04	57	116	4	IPR027359
Domain	-	SCN1A SCN2A SCN3A SCN8A	4.33e-04	57	116	4	1.20.120.350
Domain	WxxW_domain	MUC2 MUC5AC	5.64e-04	6	116	2	IPR025155
Domain	Mucin2_WxxW	MUC2 MUC5AC	5.64e-04	6	116	2	PF13330
Domain	EGF	LAMA2 CUBN ADAM22 SVEP1 SUSD1 ADGRE3 PLAU	6.66e-04	235	116	7	SM00181
Domain	EGF_3	ADAM18 CUBN ADAM22 SVEP1 SUSD1 ADGRE3 PLAU	6.66e-04	235	116	7	PS50026
Domain	S1	SRBD1 SUPT6H	1.04e-03	8	116	2	PF00575
Domain	EGF_1	ADAM18 LAMA2 CUBN ADAM22 SVEP1 SUSD1 PLAU	1.07e-03	255	116	7	PS00022
Domain	-	EPHB2 LAMA2 EPHA2 HERC2	1.11e-03	73	116	4	2.60.120.260
Domain	RuvA_2-like	SRBD1 SUPT6H	1.34e-03	9	116	2	IPR010994
Domain	IQ	SCN1A SCN2A SCN3A SCN8A	1.63e-03	81	116	4	SM00015
Domain	S1	SRBD1 SUPT6H	1.67e-03	10	116	2	PS50126
Domain	VWFA	ITGA1 SVEP1 PARP4 MDN1	1.70e-03	82	116	4	PS50234
Domain	VWA	ITGA1 SVEP1 PARP4 MDN1	1.86e-03	84	116	4	SM00327
Domain	EGF_CA	CUBN SVEP1 SUSD1 ADGRE3	2.03e-03	86	116	4	PF07645
Domain	GFP-like	SVEP1 SUSD1	2.03e-03	11	116	2	IPR023413
Domain	-	SVEP1 SUSD1	2.03e-03	11	116	2	2.40.155.10
Domain	TRYPSIN_SER	CFI GZMB CMA1 PLAU	2.39e-03	90	116	4	IPR033116
Domain	IQ_motif_EF-hand-BS	SCN1A SCN2A SCN3A SCN8A	2.39e-03	90	116	4	IPR000048
Domain	S1	SRBD1 SUPT6H	2.42e-03	12	116	2	SM00316
Domain	ABC_A	ABCA3 ABCA4	2.42e-03	12	116	2	IPR026082
Domain	S1_dom	SRBD1 SUPT6H	2.42e-03	12	116	2	IPR022967
Domain	S1_domain	SRBD1 SUPT6H	2.42e-03	12	116	2	IPR003029
Domain	C8	MUC2 MUC5AC	2.42e-03	12	116	2	PF08742
Domain	TIL	MUC2 MUC5AC	2.42e-03	12	116	2	PF01826
Domain	IQ	SCN1A SCN2A SCN3A SCN8A	2.70e-03	93	116	4	PS50096
Domain	Cyt_P450_E_grp-I	CYP4A11 CYP20A1 CYP4A22	2.74e-03	45	116	3	IPR002401
Domain	Galactose-bd-like	EPHB2 LAMA2 EPHA2 HERC2	2.80e-03	94	116	4	IPR008979
Domain	Unchr_dom_Cys-rich	MUC2 MUC5AC	2.85e-03	13	116	2	IPR014853
Domain	C8	MUC2 MUC5AC	2.85e-03	13	116	2	SM00832
Domain	-	AGO2 REXO5 POLG	3.10e-03	47	116	3	3.30.420.10
Domain	EGF_Ca-bd_CS	CUBN SVEP1 SUSD1 ADGRE3	3.14e-03	97	116	4	IPR018097
Domain	ABC_tran	ABCA3 ABCA4 ABCG5	3.29e-03	48	116	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCA3 ABCA4 ABCG5	3.29e-03	48	116	3	PS50893
Domain	RECEPTOR_TYR_KIN_V_2	EPHB2 EPHA2	3.31e-03	14	116	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHB2 EPHA2	3.31e-03	14	116	2	PS00790
Domain	Tyr_kinase_rcpt_V_CS	EPHB2 EPHA2	3.31e-03	14	116	2	IPR001426
Domain	TIL_dom	MUC2 MUC5AC	3.31e-03	14	116	2	IPR002919
Domain	EphA2_TM	EPHB2 EPHA2	3.31e-03	14	116	2	PF14575
Domain	Ephrin_rcpt_lig-bd_dom	EPHB2 EPHA2	3.31e-03	14	116	2	IPR001090
Domain	Eph_TM	EPHB2 EPHA2	3.31e-03	14	116	2	IPR027936
Domain	EPH_lbd	EPHB2 EPHA2	3.31e-03	14	116	2	SM00615
Domain	Ephrin_lbd	EPHB2 EPHA2	3.31e-03	14	116	2	PF01404
Domain	Tyr_kinase_ephrin_rcpt	EPHB2 EPHA2	3.31e-03	14	116	2	IPR016257
Domain	EPH_LBD	EPHB2 EPHA2	3.31e-03	14	116	2	PS51550
Domain	EGF_CA	CUBN SVEP1 SUSD1 ADGRE3	3.38e-03	99	116	4	PS01187
Domain	VWF_A	ITGA1 SVEP1 PARP4 MDN1	3.38e-03	99	116	4	IPR002035
Domain	ABC_TRANSPORTER_1	ABCA3 ABCA4 ABCG5	3.49e-03	49	116	3	PS00211
Domain	ASX_HYDROXYL	CUBN SVEP1 SUSD1 ADGRE3	3.50e-03	100	116	4	PS00010
Domain	TRYPSIN_HIS	CFI GZMB CMA1 PLAU	3.89e-03	103	116	4	IPR018114
Domain	EGF-type_Asp/Asn_hydroxyl_site	CUBN SVEP1 SUSD1 ADGRE3	4.31e-03	106	116	4	IPR000152
Domain	TRYPSIN_SER	CFI GZMB CMA1 PLAU	4.31e-03	106	116	4	PS00135
Domain	VWF_type-D	MUC2 MUC5AC	4.34e-03	16	116	2	IPR001846
Domain	VWFD	MUC2 MUC5AC	4.34e-03	16	116	2	PS51233
Domain	ATPase_P-typ_TM_dom	ATP2B1 ATP2B3	4.34e-03	16	116	2	IPR023298
Domain	VWD	MUC2 MUC5AC	4.34e-03	16	116	2	SM00216
Domain	-	ATP2B1 ATP2B3	4.34e-03	16	116	2	1.20.1110.10
Domain	Disintegrin_CS	ADAM18 ADAM22	4.34e-03	16	116	2	IPR018358
Domain	VWD	MUC2 MUC5AC	4.34e-03	16	116	2	PF00094
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	CAMK2D SCN1A SCN2A SCN3A SCN8A	1.86e-06	32	92	5	M27455
Pathway	REACTOME_CARDIAC_CONDUCTION	CAMK2D SCN1A SCN2A SCN3A SCN8A ATP2B1 ATP2B3	2.20e-05	130	92	7	M27454
Pathway	WP_DRAVET_SYNDROME	SCN1A SCN2A SCN3A SCN8A	3.09e-05	28	92	4	M45519
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN1A SCN2A SCN3A SCN8A	4.67e-05	31	92	4	M877
Pathway	REACTOME_MUSCLE_CONTRACTION	CAMK2D ITGA1 SCN1A SCN2A SCN3A SCN8A ATP2B1 ATP2B3	5.33e-05	203	92	8	M5485
Pathway	REACTOME_L1CAM_INTERACTIONS	EPHB2 ITGA1 SCN1A SCN2A SCN3A SCN8A	1.38e-04	121	92	6	M872
Pathway	KEGG_FATTY_ACID_METABOLISM	CYP4A11 CYP4A22 ACSL1 ALDH1B1	1.57e-04	42	92	4	M699
Pathway	WP_RETT_SYNDROME	GRIN2B SCN1A SCN2A SCN8A	2.65e-04	48	92	4	M39759
Pathway	WP_MALE_INFERTILITY	UBR2 AGO2 POLG MSH5 TEX15 LTF	3.68e-04	145	92	6	M39856
Pathway	REACTOME_FORMATION_OF_LATERAL_PLATE_MESODERM	SHH IHH	4.16e-04	5	92	2	M46432
Pathway	WP_ROLES_OF_CERAMIDES_IN_DEVELOPMENT_OF_INSULIN_RESISTANCE	TRAF1 ACSL1 SMPD3	4.33e-04	23	92	3	M45533
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN1A SCN2A SCN3A SCN8A	1.26e-10	4	118	4	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN1A SCN2A SCN3A SCN8A	1.26e-10	4	118	4	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN1A SCN2A SCN3A SCN8A	1.26e-10	4	118	4	29578003
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN1A SCN2A SCN3A SCN8A	1.88e-09	6	118	4	23652591
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN1A SCN2A SCN3A SCN8A	1.57e-08	9	118	4	16382098
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN1A SCN2A SCN3A SCN8A	1.57e-08	9	118	4	15746173
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN1A SCN2A SCN3A	3.81e-08	3	118	3	23859570
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN1A SCN2A SCN3A	3.81e-08	3	118	3	12610651
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN1A SCN2A SCN3A	3.81e-08	3	118	3	18784617
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN1A SCN2A SCN3A	3.81e-08	3	118	3	17544618
Pubmed	Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.	SCN1A SCN2A SCN8A	3.81e-08	3	118	3	32845893
Pubmed	Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.	SCN1A SCN2A SCN8A	3.81e-08	3	118	3	28518218
Pubmed	Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.	SCN1A SCN2A SCN8A	3.81e-08	3	118	3	17928448
Pubmed	Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.	SCN1A SCN2A SCN3A	3.81e-08	3	118	3	14973256
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN1A SCN2A SCN3A SCN8A	6.10e-08	12	118	4	30175250
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN1A SCN2A SCN3A SCN8A	8.79e-08	13	118	4	15123669
Pubmed	Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.	SCN1A SCN2A SCN3A	1.52e-07	4	118	3	35801810
Pubmed	Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.	SCN1A SCN2A SCN8A	1.52e-07	4	118	3	21156207
Pubmed	Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.	SCN1A SCN2A SCN3A	1.52e-07	4	118	3	8974318
Pubmed	Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.	SCN1A SCN2A SCN3A	3.79e-07	5	118	3	1679748
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	SCN1A SCN2A SCN3A	3.79e-07	5	118	3	8812438
Pubmed	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.	SCN1A SCN2A SCN3A	3.79e-07	5	118	3	24337656
Pubmed	Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.	SCN2A SCN3A SCN8A	3.79e-07	5	118	3	17724025
Pubmed	Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.	SCN1A SCN2A SCN8A	1.32e-06	7	118	3	25818041
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	ABCA3 ABCA4 CYP4A11 SLC15A1 GZMB ALDH1B1 ABCG5	4.56e-06	193	118	7	19343046
Pubmed	Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.	SCN1A SCN2A SCN3A	8.19e-06	12	118	3	8169823
Pubmed	Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid.	CYP4A11 CYP4A22 PPARGC1B	1.06e-05	13	118	3	32266253
Pubmed	Defining a new role of GW182 in maintaining miRNA stability.	AGO2 TNRC6A	1.14e-05	2	118	2	23090477
Pubmed	Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.	CYP4A11 CYP4A22	1.14e-05	2	118	2	15611369
Pubmed	Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.	SCN2A SCN3A	1.14e-05	2	118	2	20346423
Pubmed	Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.	SCN1A SCN8A	1.14e-05	2	118	2	37901435
Pubmed	Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.	SHH IHH	1.14e-05	2	118	2	28574612
Pubmed	An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.	SCN1A SCN8A	1.14e-05	2	118	2	26410685
Pubmed	Cholesterol modification of hedgehog signaling proteins in animal development.	SHH IHH	1.14e-05	2	118	2	8824192
Pubmed	Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.	SCN1A SCN2A	1.14e-05	2	118	2	10827969
Pubmed	Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.	SCN1A SCN2A	1.14e-05	2	118	2	19694741
Pubmed	Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.	SCN2A SCN8A	1.14e-05	2	118	2	35348308
Pubmed	Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.	SCN2A SCN3A	1.14e-05	2	118	2	11245985
Pubmed	Hedgehog can drive terminal differentiation of amniote slow skeletal muscle.	SHH IHH	1.14e-05	2	118	2	15238161
Pubmed	Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.	SCN2A SCN8A	1.14e-05	2	118	2	15760941
Pubmed	The ferroportin-ceruloplasmin system and the mammalian iron homeostasis machine: regulatory pathways and the role of lactoferrin.	SLC40A1 LTF	1.14e-05	2	118	2	29453656
Pubmed	Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors.	EPHB2 GRIN2B	1.14e-05	2	118	2	11799243
Pubmed	Differential expression of two sodium channel subtypes in human brain.	SCN1A SCN2A	1.14e-05	2	118	2	1317301
Pubmed	Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.	SCN2A SCN3A	1.14e-05	2	118	2	23016767
Pubmed	Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.	CYP4A11 CYP4A22	1.14e-05	2	118	2	23641057
Pubmed	Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.	SCN2A SCN3A	1.14e-05	2	118	2	27153334
Pubmed	Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.	SCN1A SCN3A	1.14e-05	2	118	2	24990319
Pubmed	Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.	SCN1A SCN2A	1.14e-05	2	118	2	31439038
Pubmed	The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.	CYP4A11 CYP4A22	1.14e-05	2	118	2	28912346
Pubmed	Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.	CYP4A11 CYP4A22	1.14e-05	2	118	2	24413902
Pubmed	New insight into hedgehog signaling in hematological malignancies.	SHH IHH	1.14e-05	2	118	2	24991722
Pubmed	The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients.	SHH IHH	1.14e-05	2	118	2	26201092
Pubmed	Mucolytic activity of bacterial and human chitinases.	MUC2 MUC5AC	1.14e-05	2	118	2	17321686
Pubmed	Differential requirements for shh in mammary tissue and hair follicle morphogenesis.	SHH IHH	1.14e-05	2	118	2	12217324
Pubmed	Altered expression of MUC2 and MUC5AC in progression of colorectal carcinoma.	MUC2 MUC5AC	1.14e-05	2	118	2	20731025
Pubmed	Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes.	PPP5C FHL1	1.14e-05	2	118	2	29343782
Pubmed	Localization of double-stranded small interfering RNA to cytoplasmic processing bodies is Ago2 dependent and results in up-regulation of GW182 and Argonaute-2.	AGO2 TNRC6A	1.14e-05	2	118	2	18946079
Pubmed	Hedgehog signaling regulates expansion of pancreatic epithelial cells.	SHH IHH	1.14e-05	2	118	2	15766752
Pubmed	A human-specific gene in microglia.	SIGLEC16 SIGLEC11	1.14e-05	2	118	2	16151003
Pubmed	Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction.	SHH IHH	1.14e-05	2	118	2	29088246
Pubmed	Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.	SCN1A SCN8A	1.14e-05	2	118	2	31943325
Pubmed	Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney.	CYP4A11 CYP4A22	1.14e-05	2	118	2	8031839
Pubmed	Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.	SCN1A SCN2A	1.14e-05	2	118	2	15249644
Pubmed	Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein.	CYP4A11 CYP4A22	1.14e-05	2	118	2	10860550
Pubmed	Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.	SCN1A SCN3A	1.14e-05	2	118	2	27690330
Pubmed	Global analysis of AGO2-bound RNAs reveals that miRNAs induce cleavage of target RNAs with limited complementarity.	AGO2 PRKDC	1.14e-05	2	118	2	29031931
Pubmed	IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice.	SHH IHH	1.14e-05	2	118	2	36853961
Pubmed	Lentivector transduction improves outcomes over transplantation of human HSCs alone in NOD/SCID/Fabry mice.	GLA PRKDC	1.14e-05	2	118	2	22472949
Pubmed	EphB2 stem-related and EphA2 progression-related miRNA-based networks in progressive stages of CRC evolution: clinical significance and potential miRNA drivers.	EPHB2 EPHA2	1.14e-05	2	118	2	30501625
Pubmed	Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins.	MUC2 MUC5AC	1.14e-05	2	118	2	23832517
Pubmed	Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution.	MUC2 MUC5AC	1.14e-05	2	118	2	23832516
Pubmed	Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.	CYP4A11 CYP4A22	1.14e-05	2	118	2	11320253
Pubmed	Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.	SCN2A SCN8A	1.14e-05	2	118	2	18601978
Pubmed	Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.	SCN1A SCN3A	1.14e-05	2	118	2	23965409
Pubmed	FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.	SCN2A SCN8A	1.14e-05	2	118	2	19465131
Pubmed	Characterization of the CYP4A11 gene, a second CYP4A gene in humans.	CYP4A11 CYP4A22	1.14e-05	2	118	2	12464262
Pubmed	Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.	CYP4A11 CYP4A22	1.14e-05	2	118	2	15066132
Pubmed	SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.	SCN1A SCN2A	1.14e-05	2	118	2	30693367
Pubmed	Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.	SCN2A SCN8A	1.14e-05	2	118	2	23735284
Pubmed	Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1,2-dimethylhydrazine in rat: a sequential analysis.	MUC2 MUC5AC	1.14e-05	2	118	2	17203232
Pubmed	Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.	SCN1A SCN2A	1.14e-05	2	118	2	29649454
Pubmed	Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis.	ITGA1 PRKDC	1.14e-05	2	118	2	12479823
Pubmed	20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.	CYP4A11 CYP4A22	1.14e-05	2	118	2	23825080
Pubmed	Opposite expression patterns of Sonic hedgehog and Indian hedgehog are associated with aberrant methylation status of their promoters in colorectal cancers.	SHH IHH	1.14e-05	2	118	2	20854074
Pubmed	Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.	CYP4A11 CYP4A22	1.14e-05	2	118	2	16691295
Pubmed	Combining hedgehog signaling inhibition with focal irradiation on reduction of pancreatic cancer metastasis.	SHH IHH	1.14e-05	2	118	2	23468532
Pubmed	The P450 gene superfamily: recommended nomenclature.	CYP4A11 CYP4A22	1.14e-05	2	118	2	3829886
Pubmed	Integrin alpha(v)beta(3), metalloproteinases, and sphingomyelinase-2 mediate urokinase mitogenic effect.	PLAU SMPD3	1.14e-05	2	118	2	19735728
Pubmed	DNA-dependent protein kinase interacts functionally with the RNA polymerase II complex recruited at the human immunodeficiency virus (HIV) long terminal repeat and plays an important role in HIV gene expression.	CTDP1 PRKDC	1.14e-05	2	118	2	21450944
Pubmed	Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells.	MUC2 MUC5AC	1.14e-05	2	118	2	12527922
Pubmed	Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.	CYP4A11 CYP4A22	1.14e-05	2	118	2	29277328
Pubmed	Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.	CYP4A11 CYP4A22	1.14e-05	2	118	2	21820496
Pubmed	Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.	SCN1A SCN2A	1.14e-05	2	118	2	33096315
Pubmed	Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.	CYP4A11 CYP4A22	1.14e-05	2	118	2	20943934
Pubmed	L-fucose reduces gut inflammation due to T-regulatory response in Muc2 null mice.	PRKDC MUC2	1.14e-05	2	118	2	36584066
Pubmed	The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes.	CYP4A11 CYP4A22	1.14e-05	2	118	2	2766933
Pubmed	Sodium channel expression within chronic multiple sclerosis plaques.	SCN2A SCN8A	1.14e-05	2	118	2	17805013
Pubmed	Overexpression of EphB2 in hippocampus rescues impaired NMDA receptors trafficking and cognitive dysfunction in Alzheimer model.	EPHB2 GRIN2B	1.14e-05	2	118	2	28358367
Pubmed	Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.	SCN1A SCN2A	1.14e-05	2	118	2	26311622
Pubmed	Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.	SCN1A SCN8A	1.14e-05	2	118	2	33411788
Interaction	MIB1 interactions	AGO2 PTPN22 NHLRC2 RET MAP3K4 CABLES1 PER3 N4BP2 EPHA2 TNRC6A NME7	1.11e-06	295	116	11	int:MIB1
Interaction	SCN4B interactions	SCN1A SCN2A SCN8A	1.02e-05	8	116	3	int:SCN4B
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN2A SCN3A SCN8A	5.37e-08	9	84	4	1203
GeneFamily	ATPases Ca2+ transporting	ATP2B1 ATP2B3	7.52e-04	9	84	2	1209
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHB2 EPHA2	1.87e-03	14	84	2	1095
GeneFamily	ATP binding cassette subfamily A	ABCA3 ABCA4	1.87e-03	14	84	2	805
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRIN2B ADAM22 SUSD1 IL1RAPL2 SCN2A SCN3A TRPV4 NR3C2	3.80e-08	187	118	8	2d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRIN2B ADAM22 SUSD1 IL1RAPL2 SCN2A SCN3A TRPV4 NR3C2	3.80e-08	187	118	8	e3095455d2f255854f339f6b05fa87852af0700f
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	STXBP5L GRIN2B ADAM22 SCN1A SCN2A SCN3A SCN8A ATP2B1	5.90e-08	198	118	8	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	STXBP5L GRIN2B ADAM22 SCN1A SCN2A SCN3A SCN8A ATP2B1	5.90e-08	198	118	8	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	STXBP5L GRIN2B ADAM22 SCN1A SCN2A SCN3A SCN8A ATP2B1	5.90e-08	198	118	8	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC40A1 RAB33A SLC15A1 NR3C2 LTF FHL1 NME7	3.32e-07	168	118	7	03896466698a79f7f1ad862cb7e05585260e2a5a
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MARK1 KDM3B RET MAP3K4 CABLES1 PPARGC1B PER3	5.29e-07	180	118	7	c72f15763ba707189e29c85db533557f01c7fdb1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRIN2B ADAM22 SUSD1 IL1RAPL2 SCN2A TRPV4 NR3C2	5.70e-07	182	118	7	f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GRIN2B ADAM22 IL1RAPL2 SCN2A SCN3A TRPV4 NR3C2	5.92e-07	183	118	7	b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_pDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PALD1 HIVEP1 RET SUSD1 EPHA2 GZMB SMPD3	6.36e-07	185	118	7	308a98f111895071d8772bc010554471cc12fab2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRIN2B ADAM22 IL1RAPL2 SCN2A SCN3A TRPV4 NR3C2	7.35e-07	189	118	7	3a295c215b5c18e7c673f92b7af5be523421682c
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GRIN2B ADAM22 SUSD1 IL1RAPL2 SCN2A TRPV4 NR3C2	7.35e-07	189	118	7	c9565e962a13a7713056ec3dbb1b67d24f9889c7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM22 SUSD1 IL1RAPL2 SCN2A SCN3A TRPV4 NR3C2	7.35e-07	189	118	7	532aaf02b364c5c4f58a2021c7c21d86df3875c9
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	STXBP5L GRIN2B ADAM22 SCN2A SCN3A SCN8A ATP2B1	9.37e-07	196	118	7	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STXBP5L TEX15 RET SCN2A SCN3A SCN8A SMPD3	1.00e-06	198	118	7	8f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	STXBP5L GRIN2B ADAM22 SCN1A SCN2A SCN8A ATP2B1	1.00e-06	198	118	7	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STXBP5L TEX15 RET SCN2A SCN3A SCN8A SMPD3	1.00e-06	198	118	7	e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	STXBP5L GRIN2B ADAM22 SCN2A SCN3A SCN8A ATP2B1	1.00e-06	198	118	7	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	STXBP5L GRIN2B ADAM22 SCN2A SCN3A SCN8A ATP2B1	1.07e-06	200	118	7	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC40A1 SLC15A1 RECQL5 FHL1 ATP2B1 ABCG5	4.69e-06	162	118	6	bc63a96ad3ba0b3433e3679d7a005f47709ff384
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 LAMA2 TEX15 SVEP1 RAB33A FHL1	5.78e-06	168	118	6	4b2d29a7843bf45922038c093ca7ec0600756adc
ToppCell	metastatic_Brain-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	ZHX3 HIVEP1 EPHA2 GZMB SMPD3 FHL1	5.78e-06	168	118	6	4bf3f85aac4b335efa93d22c9ce7b153cb5ce152
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-pDC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	HDAC9 PALD1 HIVEP1 RET GZMB SMPD3	7.30e-06	175	118	6	37c2d4e0b6e9a3171931797ce9a54f3347288e57
ToppCell	ILEUM-inflamed-(3)_pDC\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PALD1 HIVEP1 SHH SUSD1 GZMB SMPD3	7.54e-06	176	118	6	b9f847dd55703e413f3cd815eef5724fffaf13b3
ToppCell	Control-Myeloid-pDC\|Control / Disease state, Lineage and Cell class	HDAC9 PALD1 HIVEP1 RET GZMB SMPD3	7.79e-06	177	118	6	3940663bb5b45b2ca9f772550380a516c53e410b
ToppCell	metastatic_Brain-B_lymphocytes-GrB-secreting_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	PALD1 DCAF5 SUSD1 EPHA2 GZMB SMPD3	7.79e-06	177	118	6	43e1d0d3cf8f0c02e67d91f8dd1761df23d59e07
ToppCell	Control-Myeloid-pDC\|World / Disease state, Lineage and Cell class	HDAC9 PALD1 HIVEP1 RET GZMB SMPD3	8.05e-06	178	118	6	20ef63d925e67ddd5955832312ca8574a6f838a4
ToppCell	390C-Lymphocytic-ILC-ILC-1\|390C / Donor, Lineage, Cell class and subclass (all cells)	GALNS PTPN22 CHADL ITGA1 TAMM41 TNRC6A	8.31e-06	179	118	6	e7045e27f0eb88f552b31c04b56d78e5ccd7a36c
ToppCell	moderate-Myeloid-pDC\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PALD1 RET MDN1 SUSD1 GZMB SMPD3	8.58e-06	180	118	6	1d8df7df03a71f49d6683554d3c948ce90dda42e
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNS SLC40A1 ACSL1 PLAU LTF TACC3	8.85e-06	181	118	6	566249e04dd491e6287ad2101b7b1ab11031ed8b
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNS SLC40A1 ACSL1 PLAU LTF TACC3	8.85e-06	181	118	6	db9528dc7cb0230e4c36cb27da69102c588c7ee9
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	STXBP5L RET SCN2A SCN3A SCN8A SMPD3	9.13e-06	182	118	6	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM22 SUSD1 IL1RAPL2 SCN2A TRPV4 NR3C2	1.00e-05	185	118	6	d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHB2 COL5A1 MARK1 CFI SCN2A FHL1	1.03e-05	186	118	6	827f2f2ddde315d1e5970dd56f906c555ec699af
ToppCell	Monocytes-M2-like_CD16+_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	CTTNBP2 SLC40A1 CABLES1 PER3 TRPV4 SIGLEC11	1.07e-05	187	118	6	59e31c51183ed4c9a3d0792c8005ea3a12b28dfa
ToppCell	Control-Fibroblasts-Other_FB\|Control / group, cell type (main and fine annotations)	COL5A1 MARK1 LAMA2 ITGA1 SVEP1 FHL1	1.07e-05	187	118	6	bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM22 SUSD1 IL1RAPL2 SCN2A TRPV4 NR3C2	1.10e-05	188	118	6	58ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HDAC9 PALD1 DOCK8 PTPN22 ACSL1 CD1D	1.10e-05	188	118	6	0d7296ad26e97ad91c6927a6cfe4e6e70a74c5a6
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Dendritic-pDC\|lymph-node_spleen / Manually curated celltypes from each tissue	PALD1 RET SUSD1 EPHA2 GZMB SMPD3	1.13e-05	189	118	6	6c2ace61a7d62bcf7e76b73e2da8b722d03e713b
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HDAC9 PALD1 DOCK8 PTPN22 ACSL1 CD1D	1.17e-05	190	118	6	7c402aa47f1bd7decacc366c1ed1a37e39b95c73
ToppCell	3'_v3-Lung-Myeloid_Dendritic-DC2\|Lung / Manually curated celltypes from each tissue	HDAC9 PALD1 PPIF CD1D SLC15A1 PLAU	1.17e-05	190	118	6	468525c05e38158a3b8a445882b2d63dfb1d2c63
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SUSD1 IL1RAPL2 SCN2A SCN3A TRPV4 NR3C2	1.20e-05	191	118	6	3e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Dendritic\|lymph-node_spleen / Manually curated celltypes from each tissue	PALD1 RET EPHA2 GZMB PLAU SMPD3	1.20e-05	191	118	6	c3ff4342e0eea1e1f071b1fbca14a6dd4df0c696
ToppCell	MNPs-Dendritic_Cells\|MNPs / lung cells shred on cell class, cell subclass, sample id	HDAC9 PALD1 CTTNBP2 SLC40A1 CD1D RAB33A	1.27e-05	193	118	6	0e6b8e179bfe1c6e93137c76c76a91c7782a4989
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STXBP5L GRIN2B KCNH3 SCN1A SCN2A SCN8A	1.27e-05	193	118	6	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STXBP5L GRIN2B KCNH3 SCN1A SCN2A SCN8A	1.27e-05	193	118	6	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STXBP5L GRIN2B KCNH3 SCN1A SCN2A SCN8A	1.27e-05	193	118	6	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	Mesenchymal-matrix_fibroblast_1_cell\|World / Lineage, Cell type, age group and donor	COL5A1 CTTNBP2 LAMA2 ITGA1 SVEP1 FHL1	1.27e-05	193	118	6	acad568621ed677031797b8c2e34dafea798d681
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL5A1 CTTNBP2 LAMA2 ITGA1 SVEP1 FHL1	1.31e-05	194	118	6	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SUSD1 IL1RAPL2 SCN2A SCN3A TRPV4 NR3C2	1.31e-05	194	118	6	04bfc555743f7d8821439d05ae442d15e9886c59
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM22 IL1RAPL2 SCN2A SCN3A TRPV4 NR3C2	1.31e-05	194	118	6	4d6c9b016e3a0641954a8ea10c97d1cd76fadd9f
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SUSD1 IL1RAPL2 SCN2A SCN3A TRPV4 NR3C2	1.31e-05	194	118	6	69bff17df4a760ccf081cf52ff04af02c14f448d
ToppCell	Biopsy_Control_(H.)-Immune-pDCs\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	HDAC9 PALD1 RET SUSD1 GZMB SMPD3	1.35e-05	195	118	6	47d139215f0b51f5ea9b5fb09b1100e320e3f1e2
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	COL5A1 CTTNBP2 LAMA2 SLC40A1 SVEP1 FHL1	1.35e-05	195	118	6	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D122\|Adult / Lineage, Cell type, age group and donor	COL5A1 LAMA2 ITGA1 SLC40A1 SVEP1 FHL1	1.35e-05	195	118	6	aa0add081881d349099d12efca5cdee098038d4e
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK8 PPIF ACSL1 PLAU PRKDC ATP2B1	1.39e-05	196	118	6	fe8d3f45a64323947c36b127355d5940eb56c0ca
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK8 PPIF ACSL1 PLAU PRKDC ATP2B1	1.39e-05	196	118	6	526d037bb12d81f1c235c60ddc787fbad0bbad77
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK8 PPIF ACSL1 PLAU PRKDC ATP2B1	1.43e-05	197	118	6	3cd1c816bc7a57278b2ef615b69545356ab8f522
ToppCell	ASK452-Mesenchymal-Fibroblast\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	COL5A1 LAMA2 SVEP1 PLAU FHL1 RNF180	1.52e-05	199	118	6	4d0bf2a4bd97e5a3bfe4570a201cc21bb9c4c1f6
ToppCell	ASK452-Mesenchymal\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	COL5A1 LAMA2 SVEP1 PLAU FHL1 RNF180	1.52e-05	199	118	6	93e85e3731a9ece9aee3eb82c5dfdad331ee62d6
ToppCell	PCW_10-12-Mesenchymal\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	COL5A1 LAMA2 ITGA1 SLC40A1 SVEP1 FHL1	1.52e-05	199	118	6	a09292de4c4447b8eee55d401808e43b817321cc
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_\|World / Primary Cells by Cluster	CTTNBP2 GRIN2B KIDINS220 SCN2A SCN3A ATP2B1	1.52e-05	199	118	6	058373b4ac3cec2108cb24265628ff0a50646e33
ToppCell	droplet-Liver-nan-3m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HDAC9 GALNS ARMCX4 SLC40A1 CABLES1	2.24e-05	127	118	5	39fa20a55de3af1a62ab5dfa4877879db3935ac2
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SUSD1 EPHA2 SCN3A GZMB SMPD3	4.38e-05	146	118	5	bee5074c29b132180d35f57d307e342efa9b8cd1
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB2 ZGRF1 MSH5 TEX15 SCN3A	4.98e-05	150	118	5	47ea08d7609e1d2382bf56ef9e5c767e3597cf93
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-pDC\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HDAC9 PTPN22 ADAM22 SUSD1 GZMB	5.30e-05	152	118	5	0c6dd41142e4ca1e54ca41e05e42ed29fbf0e570
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 LAMA2 ITGA1 SVEP1 SMPD3	6.56e-05	159	118	5	e812cbde59188924c6277c3feadf1a9592fa62a4
ToppCell	Adult-Mesenchymal-chondrocyte\|Adult / Lineage, Cell type, age group and donor	COL5A1 REXO5 LAMA2 SLC40A1 SVEP1	6.56e-05	159	118	5	3f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 LAMA2 ITGA1 SVEP1 SMPD3	6.56e-05	159	118	5	2607b562903228274fbd96168ba826782fab0b53
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAF1 PTPN22 RET GZMB CMA1	6.56e-05	159	118	5	d2de9391b00b6c47f5fe28a1bad6da2097107ee0
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAF1 PTPN22 RET GZMB CMA1	6.56e-05	159	118	5	da6b7f8039adc19839d6c090a0b3d68fb6445a79
ToppCell	URO-Other-RBC\|URO / Disease, Lineage and Cell Type	RET GZMB SMPD3 FHL1 NME7	6.76e-05	160	118	5	558f3b0719e2461a69e1b93b08e21675e8d07a5a
ToppCell	COVID_non-vent-Lymphocytic-Dendritic-pDC\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	PALD1 EPHA2 GZMB PLAU SMPD3	6.76e-05	160	118	5	61f4cb4eb4313d8318aadbb99595a6cb7fd919f7
ToppCell	URO-Other\|URO / Disease, Lineage and Cell Type	RET GZMB SMPD3 FHL1 NME7	6.76e-05	160	118	5	b0923e6bacfaba8ca40aa5706bf270eea0938b0a
ToppCell	COVID_non-vent-Lymphocytic-Dendritic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	PALD1 EPHA2 GZMB PLAU SMPD3	6.76e-05	160	118	5	34b4f710cfcb6ec370b8b074f3cbfe272f392cec
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CRYBG2 CUBN SLC40A1 ACSL1 LTF	6.76e-05	160	118	5	bb1bb3673059768c0ea0160d29fff127f3a4ecb4
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CRYBG2 CUBN SLC40A1 ACSL1 LTF	6.76e-05	160	118	5	76f49b8b4450fa8acd36326bfa36a5d1f4bd95fb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 LAMA2 ITGA1 RET SVEP1	7.17e-05	162	118	5	bfaeff19bb56598fdc8c82be71d51787cf13928f
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_dendritic\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	COL5A1 CABLES1 FHL1 MUC2 MUC5AC	7.17e-05	162	118	5	233011408f022647932c81ebab78f9813e3c6833
ToppCell	facs-GAT-Fat-24m-Lymphocytic-NK_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN22 CD1D GZMB CMA1 TACC3	7.38e-05	163	118	5	e58863a462cc504bced627f004a47890ee2307ce
ToppCell	facs-Trachea-18m-Epithelial-glandular_epithelial-lung_secretory_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GALNS KCNH3 TG SLC15A1 TRPV4	7.60e-05	164	118	5	cdb8cd2d6b369189ea77e4946738e2816d502e03
ToppCell	facs-Trachea-18m-Epithelial-glandular_epithelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GALNS KCNH3 TG SLC15A1 TRPV4	7.60e-05	164	118	5	5dbfcdd450f652b16d97da53b528d4584b0eabcf
ToppCell	390C-Lymphocytic-ILC\|390C / Donor, Lineage, Cell class and subclass (all cells)	ZGRF1 PTPN22 CHADL ITGA1 SMPD3	7.60e-05	164	118	5	b0fc63b72162b5cc4d1e0a271a12f3d3ab29398f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM22 SCN2A SCN3A TRPV4 NR3C2	7.60e-05	164	118	5	6fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCell	metastatic_Brain-Myeloid_cells-pDCs\|metastatic_Brain / Location, Cell class and cell subclass	HIVEP1 N4BP2 GZMB SMPD3 CORO7	7.60e-05	164	118	5	06db4cc064f0765c481ce880207823872c27bfa9
ToppCell	Adult-Mesenchymal-chondrocyte-D231\|Adult / Lineage, Cell type, age group and donor	COL5A1 REXO5 LAMA2 SLC40A1 SVEP1	7.60e-05	164	118	5	2ba57dce5f69a88f0d1e450b9780425e2d9ca7d4
ToppCell	facs-Trachea-18m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GALNS KCNH3 TG SLC15A1 TRPV4	7.60e-05	164	118	5	f1423f4434af4af9c60c8a5b0b0abec4a7df9401
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PABIR1 HDAC9 MARK1 ITGA1 ADAM22	7.82e-05	165	118	5	3d14f37b8a9c0ddc1130e60a2e08556bad1fb855
ToppCell	368C-Myeloid-Dendritic-pDC\|368C / Donor, Lineage, Cell class and subclass (all cells)	TMEM67 SUSD1 EPHA2 GZMB SMPD3	8.28e-05	167	118	5	1e2fc1637769405a61f4c7e44945712a1888a299
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRAF1 ABCA3 ADAM22 KCNH3 LTF	8.28e-05	167	118	5	8b223333c0c7a85b5a1af6f2f5b12ee0d94357f6
ToppCell	Bronchial_Biopsy-Immune-Mast_cells\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	ZHX3 ABCA3 CTTNBP2 OR2L13 ADAM22	8.51e-05	168	118	5	45ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HDAC9 GLA TRPV4 RNF180 SMC1B	8.51e-05	168	118	5	4ae9e9d93bcd6f4d5815e57fd5afa7a3398a0ec1
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HDAC9 GLA TRPV4 RNF180 SMC1B	8.51e-05	168	118	5	04e168fe1d6f5f9e3d3bf9d7c13e800e3594868a
ToppCell	metastatic_Brain-B_lymphocytes-GrB-secreting_B_cells\|metastatic_Brain / Location, Cell class and cell subclass	HDAC9 RPUSD4 SUSD1 GZMB SMPD3	8.75e-05	169	118	5	71f6761b9927f352e0ccc221ca373319915f4184
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HIVEP1 RET N4BP2 GZMB SMPD3	9.25e-05	171	118	5	4fd2c7977c512c51507f055fc74b111c0228ed8b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 LAMA2 SVEP1 MAP3K4 ATP2B3	9.25e-05	171	118	5	972fab891135bd755d5526cbc5a963200067b0a6
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RET SLC40A1 PLAU LTF HCFC2	9.25e-05	171	118	5	913bae728b5e653771a27c79a309eb023699f1d0
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RET SLC40A1 PLAU LTF HCFC2	9.25e-05	171	118	5	f28b2336057e353b96a6ff4581ec9fd0ca0789d9
ToppCell	368C-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	TMEM67 SUSD1 EPHA2 GZMB SMPD3	9.25e-05	171	118	5	f3bf5805823d5733b58742172e7668725ce82931
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 TEX15 SVEP1 RAB33A FHL1	9.25e-05	171	118	5	5d31fc9b60329d4ae3c77e4ca679359d9314397d
Drug	Idazoxan hydrochloride [79944-56-2]; Up 200; 16.6uM; PC3; HT_HG-U133A	COL5A1 MARK1 TEX15 ZNF768 ADAM22 RAB33A KIDINS220 RECQL5 ALDH1B1 ATP2B3	8.11e-08	197	118	10	6747_UP
Drug	Hecogenin [467-55-0]; Up 200; 9.2uM; HL60; HT_HG-U133A	ZHX3 CRYBG2 STXBP5L PTPN22 TEX15 PER3 RECQL5 NR3C2 FHL1	9.37e-07	198	118	9	2716_UP
Drug	APETx1, Anthopleura elegantissima	SCN2A SCN3A SCN8A	2.68e-06	6	118	3	ctd:C475726
Drug	Methimazole	POLG SHH PTPN22 RET CUBN SLC40A1 DCAF5 TG AGL NR3C2 TACC3 ATP2B3	3.00e-06	438	118	12	ctd:D008713
Drug	2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate	SCN2A SCN3A SCN8A	7.46e-06	8	118	3	ctd:C489827
Drug	Nadide [53-84-9]; Up 200; 6uM; HL60; HT_HG-U133A	CRYBG2 TRAF1 GRIN2B PER3 PPP5C IL1RAPL2 RECQL5 IHH	8.21e-06	195	118	8	2529_UP
Drug	glycine ethyl ester	CHIA GALNS AGL SCN2A	9.38e-06	26	118	4	CID000012175
Drug	Chlorpropamide [94-20-2]; Up 200; 14.4uM; MCF7; HT_HG-U133A	EPHB2 ZHX3 ADAM18 ADAM22 IL1RAPL2 ADGRE3 PLAU FHL1	9.87e-06	200	118	8	5391_UP
Drug	nifedipine	PALD1 COL5A1 CYP4A11 CYP20A1 GRIN2B SLC40A1 CYP4A22 PPIF TRPV4 ATP2B1 ATP2B3	1.08e-05	415	118	11	CID000004485
Drug	Coal Ash	EPHB2 COL5A1 MAP3K4 MUC2 MUC5AC ATP2B1 ATP2B3	1.95e-05	159	118	7	ctd:D060729
Drug	2-amino-2-deoxygalacturonic acid	GALNS GLA	2.66e-05	2	118	2	CID000193487
Drug	L-beta-aspartyl phosphate	TG GLA CTDP1 ATP2B1 ATP2B3	2.96e-05	69	118	5	CID000000832
Drug	NSC227243	CHIA GLA SCN2A	4.74e-05	14	118	3	CID000024346
Drug	Tetrodotoxin	GRIN2B SCN2A SCN3A SCN8A	5.42e-05	40	118	4	ctd:D013779
Drug	chloral hydrate	CYP4A11 CYP20A1 GRIN2B CYP4A22 PPARGC1B ALDH1B1	5.77e-05	129	118	6	CID000002707
Drug	Phytosterols	PPARGC1B LTF ABCG5	5.90e-05	15	118	3	ctd:D010840
Drug	Ovalbumin	COL5A1 CHIA CFI MUC2 MUC5AC	6.81e-05	82	118	5	ctd:D010047
Drug	Etifenin [63245-28-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A	ADAM22 SVEP1 TG PPP5C RECQL5 TRPV4 MUC5AC	6.95e-05	194	118	7	4117_UP
Drug	Leflunomide [75706-12-6]; Up 200; 14.8uM; PC3; HT_HG-U133A	LAMA2 PTPN22 IL1RAPL2 SUPT6H STOML1 RECQL5 ALDH1B1	7.18e-05	195	118	7	5884_UP
Drug	Cefsulodin sodium salt [52152-93-9]; Up 200; 7.2uM; MCF7; HT_HG-U133A	CFI RAB33A PPP5C SLC15A1 ADGRE3 STOML1 FHL1	7.18e-05	195	118	7	4148_UP
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Up 200; 25.2uM; MCF7; HT_HG-U133A	TG ADGRE3 STOML1 RECQL5 SCN8A CMA1 FHL1	7.41e-05	196	118	7	3930_UP
Drug	Drofenine hydrochloride [548-66-3]; Up 200; 11.4uM; PC3; HT_HG-U133A	EPHB2 COL5A1 REXO5 PPP5C STOML1 ALDH1B1 MUC5AC	7.41e-05	196	118	7	7129_UP
Drug	Sodium	SCN2A SCN3A SCN8A TRPV4 NR3C2	7.65e-05	84	118	5	ctd:D012964
Drug	Clemizole hydrochloride [1163-36-6]; Up 200; 11uM; PC3; HT_HG-U133A	TEX15 SLC15A1 SCN1A RECQL5 HRG ALDH1B1 MUC5AC	7.65e-05	197	118	7	3672_UP
Drug	estradiol; Up 200; 0.01uM; PC3; HT_HG-U133A	EPHB2 COL5A1 ZHX3 POLG SVEP1 RECQL5 TRPV4	7.65e-05	197	118	7	5960_UP
Drug	Rapamycin; Up 200; 0.1uM; HL60; HT_HG-U133A	ITGA1 PPARGC1B RAB33A PER3 STOML1 NR3C2 FHL1	7.65e-05	197	118	7	2667_UP
Drug	Amphotericin B [1397-89-3]; Up 200; 4.4uM; MCF7; HT_HG-U133A	EPHB2 COL5A1 PTPN22 RAB33A SLC15A1 STOML1 MUC5AC	7.65e-05	197	118	7	3303_UP
Drug	2-propylpentanoic acid; Down 200; 500uM; MCF7; HT_HG-U133A	EPHB2 ZHX3 POLG CYP20A1 PPP5C EPHA2 RECQL5	7.65e-05	197	118	7	6999_DN
Drug	Dequalinium dichloride [522-51-0]; Up 200; 7.6uM; PC3; HT_HG-U133A	EPHB2 ZHX3 CRYBG2 TEX15 ADAM22 IL1RAPL2 RECQL5	7.90e-05	198	118	7	6296_UP
Drug	Aztreonam [78110-38-0]; Up 200; 9.2uM; PC3; HT_HG-U133A	CRYBG2 PTPN22 ZNF768 TG PPP5C SUPT6H STOML1	7.90e-05	198	118	7	5110_UP
Drug	Liothyronine [6893-02-3]; Up 200; 6.2uM; PC3; HT_HG-U133A	COL5A1 POLG TEX15 ADGRE3 RECQL5 MUC5AC ABCG5	8.15e-05	199	118	7	6602_UP
Drug	Monocrotaline [315-22-0]; Up 200; 12.2uM; MCF7; HT_HG-U133A	CRYBG2 ZNF768 TG PER3 STOML1 HRG FHL1	8.15e-05	199	118	7	6771_UP
Drug	Isopyrin hydrochloride [18342-39-7]; Up 200; 14.2uM; PC3; HT_HG-U133A	EPHB2 ABCA3 ADAM22 KIDINS220 SUPT6H RECQL5 CTDP1	8.15e-05	199	118	7	5879_UP
Drug	Proparacaine hydrochloride [5875-06-9]; Down 200; 12uM; MCF7; HT_HG-U133A	COL5A1 KIDINS220 PER3 EPHA2 RECQL5 HCFC2 TRDMT1	8.15e-05	199	118	7	6492_DN
Drug	Piracetam [7491-74-9]; Down 200; 28.2uM; PC3; HT_HG-U133A	EPHB2 ABCA3 KIDINS220 PER3 CTDP1 SCN8A ALDH1B1	8.41e-05	200	118	7	5043_DN
Drug	fluphenazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A	EPHB2 ZHX3 ZNF337 POLG PPP5C EPHA2 ALDH1B1	8.41e-05	200	118	7	6996_DN
Drug	Zonisamide	SCN1A SCN2A SCN3A	8.75e-05	17	118	3	DB00909
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN8A	4.36e-08	10	114	4	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN8A	4.36e-08	10	114	4	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN8A	1.02e-07	12	114	4	DOID:0060170 (implicated_via_orthology)
Disease	anxiety disorder (implicated_via_orthology)	KDM3B SCN1A SCN2A SCN3A	1.46e-06	22	114	4	DOID:2030 (implicated_via_orthology)
Disease	cystitis (is_marker_for)	MUC2 MUC5AC	1.48e-05	2	114	2	DOID:1679 (is_marker_for)
Disease	Infantile Severe Myoclonic Epilepsy	SCN1A SCN2A TNRC6A	1.56e-05	13	114	3	C0751122
Disease	Epilepsy, Cryptogenic	POLG GRIN2B SCN1A SCN2A SCN8A	1.70e-05	82	114	5	C0086237
Disease	Awakening Epilepsy	POLG GRIN2B SCN1A SCN2A SCN8A	1.70e-05	82	114	5	C0751111
Disease	Aura	POLG GRIN2B SCN1A SCN2A SCN8A	1.70e-05	82	114	5	C0236018
Disease	Neurodevelopmental Disorders	DOCK8 GRIN2B SCN1A SCN2A SCN8A	3.12e-05	93	114	5	C1535926
Disease	epilepsy (implicated_via_orthology)	CAMK2D GRIN2B SCN1A SCN2A SCN3A SCN8A	4.22e-05	163	114	6	DOID:1826 (implicated_via_orthology)
Disease	Benign familial infantile epilepsy	SCN2A SCN8A	4.43e-05	3	114	2	cv:C5575231
Disease	sputum mucin-5B amount	MUC2 MUC5AC	4.43e-05	3	114	2	OBA_2050332
Disease	chronic obstructive pulmonary disease (implicated_via_orthology)	PLAU MUC5AC	4.43e-05	3	114	2	DOID:3083 (implicated_via_orthology)
Disease	Vitiligo	PTPN22 TG PPARGC1B GZMB HERC2	4.65e-05	101	114	5	EFO_0004208
Disease	Epilepsy	POLG GRIN2B SCN1A SCN2A SCN8A	6.69e-05	109	114	5	C0014544
Disease	mucinous adenocarcinoma (is_marker_for)	MUC2 MUC5AC	1.47e-04	5	114	2	DOID:3030 (is_marker_for)
Disease	Cerebral Small Vessel Diseases	GLA SCN1A	1.47e-04	5	114	2	C2733158
Disease	tissue plasminogen activator measurement, coronary artery disease	HDAC9 MAP3K4 NME7 ATP2B1	1.68e-04	71	114	4	EFO_0001645, EFO_0004791
Disease	dietary heme iron intake measurement, type 2 diabetes mellitus	SVEP1 TNRC6A	2.20e-04	6	114	2	EFO_0008355, MONDO_0005148
Disease	Hailey-Hailey disease (implicated_via_orthology)	ATP2B1 ATP2B3	2.20e-04	6	114	2	DOID:0050429 (implicated_via_orthology)
Disease	Familial benign neonatal epilepsy	SCN2A SCN8A	2.20e-04	6	114	2	C0220669
Disease	X-14939 measurement	CYP4A11 CYP4A22	2.20e-04	6	114	2	EFO_0800747
Disease	platelet measurement	HDAC9 DOCK8 DCAF5 SVEP1 CABLES1 SIGLEC11 ALDH1B1	2.29e-04	315	114	7	EFO_0005036
Disease	Seizure, Febrile, Simple	SCN1A SCN2A	3.07e-04	7	114	2	C0149886
Disease	Seizure, Febrile, Complex	SCN1A SCN2A	3.07e-04	7	114	2	C0751057
Disease	autism spectrum disorder (is_marker_for)	SHH IHH	3.07e-04	7	114	2	DOID:0060041 (is_marker_for)
Disease	primary dental caries	GRIN2B CUBN SUSD1	3.08e-04	34	114	3	EFO_0600095
Disease	Early Childhood Epilepsy, Myoclonic	SCN1A TNRC6A	4.08e-04	8	114	2	C0393695
Disease	Idiopathic Myoclonic Epilepsy	SCN1A TNRC6A	4.08e-04	8	114	2	C0338478
Disease	Symptomatic Myoclonic Epilepsy	SCN1A TNRC6A	4.08e-04	8	114	2	C0338479
Disease	Benign Infantile Myoclonic Epilepsy	SCN1A TNRC6A	4.08e-04	8	114	2	C0751120
Disease	Myoclonic Encephalopathy	SCN1A TNRC6A	4.08e-04	8	114	2	C0438414
Disease	Myoclonic Absence Epilepsy	SCN1A TNRC6A	4.08e-04	8	114	2	C0393703
Disease	myocardial infarction	HDAC9 ZHX3 CTTNBP2 ITGA1 SLC15A1 NME7 ATP2B1	4.32e-04	350	114	7	EFO_0000612
Disease	osteoarthritis, hip	HDAC9 CHADL HERC2 TACC3	4.54e-04	92	114	4	EFO_1000786
Disease	Febrile Convulsions	SCN1A SCN2A	5.23e-04	9	114	2	C0009952
Disease	primary bacterial infectious disease (implicated_via_orthology)	SHH IHH	5.23e-04	9	114	2	DOID:0050338 (implicated_via_orthology)
Disease	bringing up phlegm, sputum or mucus on most days, self-reported	MUC2 MUC5AC	5.23e-04	9	114	2	EFO_0009824
Disease	Myoclonic Epilepsy	SCN1A TNRC6A	5.23e-04	9	114	2	C0014550
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN1A SCN2A	5.23e-04	9	114	2	C3502809
Disease	chronic obstructive pulmonary disease (is_marker_for)	GZMB CMA1 PLAU MUC5AC	5.55e-04	97	114	4	DOID:3083 (is_marker_for)
Disease	Brain hemorrhage	GLA PLAU	6.52e-04	10	114	2	C0553692
Disease	Epilepsy, Myoclonic, Infantile	SCN1A TNRC6A	6.52e-04	10	114	2	C0917800
Disease	Hirschsprung's disease (is_implicated_in)	SHH RET	7.95e-04	11	114	2	DOID:10487 (is_implicated_in)
Disease	autosomal recessive polycystic kidney disease (biomarker_via_orthology)	CYP4A11 CYP4A22	7.95e-04	11	114	2	DOID:0110861 (biomarker_via_orthology)
Disease	microfibrillar-associated protein 2 measurement	A2ML1 HRG	7.95e-04	11	114	2	EFO_0801801
Disease	Myoclonic Astatic Epilepsy	SCN1A TNRC6A	7.95e-04	11	114	2	C0393702
Disease	autoimmune thyroiditis (is_implicated_in)	PTPN22 TG	9.52e-04	12	114	2	DOID:7188 (is_implicated_in)
Disease	Hirschsprung's disease (implicated_via_orthology)	RET IHH	9.52e-04	12	114	2	DOID:10487 (implicated_via_orthology)
Disease	electrocardiography	HIVEP1 CAMK2D SHH NHLRC2 PPARGC1B HRG NR3C2 NME7	1.07e-03	530	114	8	EFO_0004327
Disease	Erythrocyte Mean Corpuscular Hemoglobin Test	GLA AGL	1.12e-03	13	114	2	C0369183
Disease	Finding of Mean Corpuscular Hemoglobin	GLA AGL	1.12e-03	13	114	2	C1261502
Disease	Hypotension	GRIN2B PLAU LTF	1.14e-03	53	114	3	C0020649
Disease	Alzheimer's disease (implicated_via_orthology)	HIVEP1 PLAU TM2D1	1.41e-03	57	114	3	DOID:10652 (implicated_via_orthology)
Disease	asthma (is_marker_for)	CHIA CMA1 PLAU MUC5AC	1.47e-03	126	114	4	DOID:2841 (is_marker_for)
Disease	MMR-related febrile seizures	SCN1A SCN2A	1.50e-03	15	114	2	EFO_0006519
Disease	lymphocyte count	HDAC9 PALD1 TRAF1 HIVEP1 ZNF337 GSX2 PTPN22 NHLRC2 ITGA1 PPP5C NR3C2 ALDH1B1 CORO7 TM2D1	1.55e-03	1464	114	14	EFO_0004587
Disease	neuroticism measurement, cognitive function measurement	HIVEP1 CTTNBP2 AGO2 TG N4BP2 SCN2A TNRC6A NR3C2	1.62e-03	566	114	8	EFO_0007660, EFO_0008354
Disease	Abnormal behavior	KDM3B TRPV4	1.71e-03	16	114	2	C0233514
Disease	Early infantile epileptic encephalopathy with suppression bursts	SCN1A SCN2A	1.71e-03	16	114	2	C0393706
Disease	Cerebrovascular accident	HDAC9 GLA PLAU	1.80e-03	62	114	3	C0038454
Disease	coronary artery disease, plasminogen activator inhibitor 1 measurement	HDAC9 NME7 ATP2B1	1.88e-03	63	114	3	EFO_0001645, EFO_0004792
Disease	pre-malignant neoplasm (biomarker_via_orthology)	SHH MUC2	1.94e-03	17	114	2	DOID:0060071 (biomarker_via_orthology)
Disease	Profound Mental Retardation	DOCK8 GRIN2B SCN1A SCN8A	2.11e-03	139	114	4	C0020796
Disease	Mental Retardation, Psychosocial	DOCK8 GRIN2B SCN1A SCN8A	2.11e-03	139	114	4	C0025363
Disease	Mental deficiency	DOCK8 GRIN2B SCN1A SCN8A	2.11e-03	139	114	4	C0917816
Disease	sinusitis (is_marker_for)	CHIA PLAU	2.17e-03	18	114	2	DOID:0050127 (is_marker_for)
Disease	nevus count	DOCK8 PPARGC1B	2.17e-03	18	114	2	EFO_0004632
Disease	Age-related macular degeneration	ABCA4 CFI	2.17e-03	18	114	2	cv:C0242383
Disease	Febrile seizure (within the age range of 3 months to 6 years)	SCN1A SCN2A	2.17e-03	18	114	2	HP_0002373
Disease	renovascular hypertension (biomarker_via_orthology)	LAMA2 CMA1	2.42e-03	19	114	2	DOID:1591 (biomarker_via_orthology)
Disease	hydrocephalus (implicated_via_orthology)	TMEM67 NME7	2.42e-03	19	114	2	DOID:10908 (implicated_via_orthology)
Disease	superior temporal gyrus volume measurement	CTTNBP2 CUBN	2.42e-03	19	114	2	EFO_0010331
Disease	type 1 diabetes mellitus	PALD1 AGO2 PTPN22 ACSL1 TACC3	2.53e-03	242	114	5	MONDO_0005147
Disease	neutrophil percentage of leukocytes	HDAC9 PALD1 UBR2 HIVEP1 DOCK8 NR3C2 PRKDC ALDH1B1	2.58e-03	610	114	8	EFO_0007990
Disease	platelet component distribution width	HDAC9 DOCK8 NHLRC2 CUBN DCAF5 SVEP1 CABLES1 NR3C2 TRDMT1	2.67e-03	755	114	9	EFO_0007984
Disease	temporal lobe epilepsy (is_marker_for)	SHH GRIN2B	2.69e-03	20	114	2	DOID:3328 (is_marker_for)
Disease	Osteoarthritis of hip	HDAC9 CHADL	2.69e-03	20	114	2	C0029410
Disease	coagulation factor V measurement	SUSD1 NME7	2.69e-03	20	114	2	EFO_0008087
Disease	urate measurement, bone density	COL5A1 CAMK2D TG KIDINS220 ADGRE3 A2ML1 NR3C2 PRKDC	2.82e-03	619	114	8	EFO_0003923, EFO_0004531
Disease	autism spectrum disorder (implicated_via_orthology)	ABCA3 SCN1A SCN2A NR3C2	2.91e-03	152	114	4	DOID:0060041 (implicated_via_orthology)
Disease	Idiopathic Pulmonary Fibrosis	ABCA3 PLAU	2.96e-03	21	114	2	C1800706
Disease	Malignant neoplasm of breast	ABCA3 ABCA4 LAMA2 CUBN PPARGC1B PER3 IL1RAPL2 N4BP2 GZMB HRG HERC2	2.99e-03	1074	114	11	C0006142
Disease	LEOPARD Syndrome	EPHA2 A2ML1	3.25e-03	22	114	2	C0175704
Disease	Lung diseases	DOCK8 RET PRKDC	3.46e-03	78	114	3	C0024115
Disease	Ovarian Serous Adenocarcinoma	MARK1 MAP3K4	3.55e-03	23	114	2	C1335177
Disease	QRS duration, response to sulfonylurea	MDN1 SLC15A1	3.55e-03	23	114	2	EFO_0005055, EFO_0007922
Disease	Endometrioma	SLC40A1 NR3C2 LTF IHH	3.58e-03	161	114	4	C0269102
Disease	Endometriosis	SLC40A1 NR3C2 LTF IHH	3.58e-03	161	114	4	C0014175
Disease	Coronary heart disease	PLAU ABCG5	3.86e-03	24	114	2	C0010068
Disease	West Syndrome	GRIN2B SCN2A	3.86e-03	24	114	2	C0037769
Disease	Noonan Syndrome	EPHA2 A2ML1	3.86e-03	24	114	2	C0028326

Protein segments in the cluster

Peptide	Gene	Start	Entry
FSKTGNLRNLFPCGD	CTDP1	281	Q9Y5B0
FGQSPDGCSSITFPK	CDY2A	421	Q9Y6F7
PGTKFLNNGTCTAEG	CFI	96	P05156
SGTPLFLKNCFGTGL	ABCA4	1141	P78363
AVICFTSGTTGNPKG	ACSL1	271	P33121
PDCKFQFGSPGGSID	ADAM18	651	Q9Y3Q7
VTCHTPFGGFKESGN	ALDH1B1	476	P30837
KTSFKGDSGGPLVCN	GZMB	196	P10144
NLSGQTDKTGCFSAP	A2ML1	281	A8K2U0
LNSGGGACLFNKPSK	ADAM22	426	Q9P0K1
DFTGTFCNQGKFPLI	CHIA	366	Q9BZP6
AFLPFSGGSRNCIGK	CYP4A11	446	Q02928
CFGLLGFNGAGKTTT	ABCA3	1411	Q99758
DVGNKTCAGFPGSFG	GLA	136	P06280
CSKPGFEDQAIGGGF	ARMCX4	1571	Q5H9R4
FGGKPFSCSELSIEQ	ATP2B1	1026	P20020
VQFGGKPFSCSPLST	ATP2B3	1021	Q16720
FFTASEGCSNPLGGG	AGO2	181	Q9UKV8
FCGGTFPDKTEATIG	RAB33A	56	Q14088
LFEGCSNSKPVNAAG	PTPN22	421	Q9Y2R2
KDPGTGFVFSCLSGQ	PALD1	651	Q9ULE6
GCGSDQPKFSFRVGQ	KCNH3	831	Q9ULD8
VCSSTSFNGPFAGGV	KIDINS220	1101	Q9ULH0
KTKIFGCQNPFRQGG	MDN1	1861	Q9NU22
INGCGIGPFSKISEF	HCFC2	656	Q9Y5Z7
SESCPGKFKSGFPQV	HRG	501	P04196
CSGTSFKGNPTVNPF	NR3C2	436	P08235
NEPGQSAVFCGRSGK	HERC2	2751	O95714
KGLNLTTPGESDGFC	CORO7	491	P57737
GCPSGTFKANQGDEA	EPHB2	271	P29323
KGQFSSAPGDAQFCP	GSX2	106	Q9BZM3
PNGGGECKTFTSFHQ	PER3	496	P56645
VGFICKNEDQFGNGP	MUC2	1361	Q02817
CLAFNSGNTKVFSGG	DCAF5	106	Q96JK2
DGNSCNVGSPFAKDF	POLG	756	P54098
LATENKPLGFSFGCS	KDM3B	496	Q7LBC6
KPLGFSFGCSSAQEA	KDM3B	501	Q7LBC6
GKFGLDAKNPLGCSS	LAMA2	1151	P24043
PFSKFANNTEGQCGT	MUC5AC	5051	P98088
GIGKQCFSPSLQSFV	PABIR1	151	Q96E09
KENGGKFSFSLNPQC	PARP4	31	Q9UKK3
GSTLVTNPNGGFLAC	ITGA1	116	P56199
KGTGPGKSFCFATAN	SMPD3	116	Q9NY59
FTESTFNEPGGLCIG	NHLRC2	526	Q8NBF2
GANTSDPLLGKFCGS	CUBN	3101	O60494
NCKQVIGTGSFFPKG	FHL1	131	Q13642
GSNGPFLCGKQTTFE	GALNS	301	P34059
NQGSPEICGFKKTGS	DOCK8	136	Q8NF50
CSLEQPGQGGSTSAF	CABLES1	261	Q8TDN4
NGTCPQFVSGLLESG	CD1D	181	P15813
TESPCTFQKGNGLSE	CTTNBP2	1221	Q8WZ74
NSFPGGASSCKETFN	EPHA2	106	P29317
AFLPFSGGSRNCIGK	CYP4A22	446	Q5TCH4
GKVIFFSESGCQGSG	CRYBG2	986	Q8N1P7
AFTQGIQFIEKTCPG	ABCG5	601	Q9H222
GEASQKFGFEVGPAC	COL5A1	1821	P20908
EFTVGNKLDTFCGSP	MARK1	206	Q9P0L2
PGGQDFARSGFSKNC	HBP1	386	O60381
FARSGFSKNCGSPGS	HBP1	391	O60381
KTFSSLGFSGTQECP	CYP20A1	396	Q6UW02
DSQKFFSSLPCGGLG	HDAC9	721	Q9UKV0
NSSGLEQICPGAFSG	CHADL	626	Q6NUI6
TGGIKPCVSAFGGDQ	SLC15A1	136	P46059
FFPSSGGCGPANTAK	NME7	221	Q9Y5B8
AAAKTGGCFPAGAQV	IHH	196	Q14623
CIPNGKENFSGGTSL	CAMK2D	481	Q13557
LSGNPTISFGGCLTQ	OR4D5	86	Q8NGN0
GARLGGFNFVSTPKC	RNF180	91	Q86T96
ILTGGLCFSSTGNFP	TMEM67	191	Q5HYA8
SGQKGISFLGCGVQS	OR2L13	86	Q8N349
RTFVPNSTECGGDKG	MSH5	571	O43196
GFNGTSVEGQCKATP	MAP3K4	316	Q9Y6R4
NGQGCGSLFTLVSKP	RPUSD4	16	Q96CM3
DPQFGTSCEITGFGK	PLAU	306	P00749
IPFGGDTKSGCSEAQ	TACC3	416	Q9Y6A5
EPNISFDGSIQCSGK	TRDMT1	211	O14717
VAAKSGGCFPGSATV	SHH	191	Q15465
FFSASCVPGADKGQF	LTF	171	P02788
LNIPCKAFFGFSGES	IL1RAPL2	261	Q9NP60
FSCALFGPDGGLVSN	OPLAH	771	O14841
GVSCQFGPDVTKAFL	PPP5C	401	P53041
ASQAGQKRPFSCSFG	PPARGC1B	676	Q86YN6
FAQNTLGNKLFACGP	SLC40A1	541	Q9NP59
GPNTNGSQFFICTIK	PPIF	146	P30405
SVKGDCGNPSVGIFF	SCN3A	1736	Q9NY46
PGFSGKRCETEQSTG	SVEP1	1411	Q4LDE5
VKGLGPKSFQQCAGF	SRBD1	751	Q8N5C6
CKNSEPFIIFSGGLS	STXBP5L	316	Q9Y2K9
SVKGDCGNPSVGIFF	SCN1A	1751	P35498
SGSGQKLFTFPLETC	ADGRE3	51	Q9BY15
IVTSNGPSKFCGGFL	CMA1	41	P23946
GAGFPKGSCPFQTAT	RECQL5	656	O94762
FDSGSCPGQAIGVKT	SUPT6H	1216	Q7KZ85
EASTGQELSKFNPCG	ZNF561	161	Q8N587
RFTCIIGPNGSGKSN	SMC1B	26	Q8NDV3
SSFGFLGSQKGCLSP	STOML1	21	Q9UBI4
TKCNGSIADNSPLFG	REXO5	216	Q96IC2
CQEGFESPGGKITSV	SUSD1	266	Q6UWL2
SVKGDCGNPSVGIFF	SCN2A	1741	Q99250
TGQRPFSCGICGKSF	ZNF768	396	Q9H5H4
TGNEVGFFKPISCRN	TM2D1	101	Q9BX74
GFKGDCGNPSVGIFF	SCN8A	1731	Q9UQD0
AGVGCSFKGSPQSVQ	TRAF1	91	Q13077
TKGIFTAGKSFGNPC	TAMM41	306	Q96BW9
KCFGTGAAGNRTSPQ	PRKDC	1311	P78527
GDGKGITRNFSTCSP	RET	546	P07949
GCQPSGLKRKFTGFQ	ZGRF1	106	Q86YA3
AGQCKDQGNFSFPIS	TEX15	146	Q9BXT5
INQASNFSCPKSGGD	UBR2	1611	Q8IWV8
LSALKGSFCRNQFPG	ZHX3	506	Q9H4I2
CTGFGFLNVSQLKGG	TG	2006	P01266
KCPGVNSLFIDGSFQ	TRPV4	536	Q9HBA0
LPGCSGFTGSLTNLQ	HIVEP1	301	P15822
DRFQLTGDPGKGSCS	SIGLEC11	101	Q96RL6
FNSGACIDKTSPNGN	TNRC6A	761	Q8NDV7
FQLTGDPGKGSCSLV	SIGLEC16	91	A6NMB1
SGEKPFVCNVCGQGF	ZNF337	651	Q9Y3M9
SLGSVQLCGVGKFPS	AGL	1041	P35573
FQKSCDGSQIGPFSL	N4BP2	1141	Q86UW6
DFKRDSVSGGGPCTN	GRIN2B	1161	Q13224