Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR5C1 OR52B4 OR5M11 OR11A1 OR5G3 OR6K2 OR5B12 OR2G2

4.91e-08431268GO:0004984
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR5C1 OR52B4 CELSR1 OR5M11 TAS2R38 OR11A1 OR5G3 OR6K2 OR5B12 OR2G2

7.65e-088842610GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR5C1 MST1R OR52B4 CELSR1 OR5M11 TAS2R38 OR11A1 OR5G3 OR6K2 OR5B12 OR2G2

3.97e-0713532611GO:0004888
GeneOntologyMolecularFunctionodorant binding

OR5C1 OR5M11 OR5G3 OR6K2 OR5B12

5.68e-07127265GO:0005549
GeneOntologyMolecularFunctionadiponectin binding

ADIPOR1 ADIPOR2

4.89e-063262GO:0055100
GeneOntologyMolecularFunctionadipokinetic hormone receptor activity

ADIPOR1 ADIPOR2

9.77e-064262GO:0097003
GeneOntologyMolecularFunctionprotein-hormone receptor activity

ADIPOR1 ADIPOR2

3.71e-0422262GO:0016500
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR5C1 OR52B4 OR5M11 TAS2R38 OR11A1 OR5G3 OR6K2 OR5B12 OR2G2

4.47e-09485269GO:0050907
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR5C1 OR52B4 OR5M11 TAS2R38 OR11A1 OR5G3 OR6K2 OR5B12 OR2G2

8.75e-09524269GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR5C1 OR52B4 OR5M11 TAS2R38 OR11A1 OR5G3 OR6K2 OR5B12 OR2G2

1.27e-08547269GO:0007606
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR5C1 OR52B4 OR5M11 TAS2R38 OR11A1 OR5G3 OR6K2 OR5B12 OR2G2

2.17e-08582269GO:0050906
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR5C1 OR52B4 OR5M11 OR11A1 OR5G3 OR6K2 OR5B12 OR2G2

3.90e-08432268GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR5C1 OR52B4 OR5M11 OR11A1 OR5G3 OR6K2 OR5B12 OR2G2

6.87e-08465268GO:0007608
GeneOntologyBiologicalProcessdetection of stimulus

OR5C1 OR52B4 OR5M11 TAS2R38 OR11A1 OR5G3 OR6K2 OR5B12 OR2G2

1.37e-07722269GO:0051606
GeneOntologyBiologicalProcesssensory perception

OR5C1 OR52B4 OR5M11 TAS2R38 OR11A1 OR5G3 OR6K2 OR5B12 OR2G2

3.75e-061072269GO:0007600
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR5C1 OR52B4 CELSR1 OR5M11 TAS2R38 OR11A1 OR5G3 OR6K2 OR5B12 OR2G2

3.78e-0613952610GO:0007186
GeneOntologyBiologicalProcessadiponectin-activated signaling pathway

ADIPOR1 ADIPOR2

3.20e-057262GO:0033211
DomainOlfact_rcpt

OR5C1 OR52B4 OR5M11 OR11A1 OR6K2 OR5B12 OR2G2

4.40e-07393247IPR000725
DomainGPCR_Rhodpsn_7TM

OR5C1 OR52B4 OR5M11 OR11A1 OR6K2 OR5B12 OR2G2

1.50e-05670247IPR017452
Domain7tm_1

OR5C1 OR52B4 OR5M11 OR11A1 OR6K2 OR5B12 OR2G2

1.61e-05677247PF00001
DomainG_PROTEIN_RECEP_F1_1

OR5C1 OR52B4 OR5M11 OR11A1 OR6K2 OR5B12 OR2G2

1.74e-05685247PS00237
DomainG_PROTEIN_RECEP_F1_2

OR5C1 OR52B4 OR5M11 OR11A1 OR6K2 OR5B12 OR2G2

1.84e-05691247PS50262
DomainGPCR_Rhodpsn

OR5C1 OR52B4 OR5M11 OR11A1 OR6K2 OR5B12 OR2G2

1.85e-05692247IPR000276
DomainAdipoR/HlyIII-related

ADIPOR1 ADIPOR2

8.64e-0511242IPR004254
DomainHlyIII

ADIPOR1 ADIPOR2

8.64e-0511242PF03006
Domain-

CELSR1 CRP

6.57e-03952422.60.120.200
Domain-

MST1R LLGL1 BIRC6

8.61e-033332432.130.10.10
DomainWD40/YVTN_repeat-like_dom

MST1R LLGL1 BIRC6

8.75e-03335243IPR015943
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR5C1 OR52B4 OR5M11 OR11A1 OR6K2 OR5B12 OR2G2

9.61e-07389217M14091
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR5C1 OR5M11 OR11A1 OR5G3 OR6K2 OR5B12 OR2G2

1.53e-06417217M4072
PathwayREACTOME_SENSORY_PERCEPTION

OR5C1 OR5M11 TAS2R38 OR11A1 OR5G3 OR6K2 OR5B12 OR2G2

1.98e-06636218M41834
PathwayREACTOME_AMPK_INHIBITS_CHREBP_TRANSCRIPTIONAL_ACTIVATION_ACTIVITY

ADIPOR1 ADIPOR2

3.16e-056212MM14630
PathwayREACTOME_AMPK_INHIBITS_CHREBP_TRANSCRIPTIONAL_ACTIVATION_ACTIVITY

ADIPOR1 ADIPOR2

5.89e-058212M26990
PathwayWP_LEPTIN_AND_ADIPONECTIN

ADIPOR1 ADIPOR2

9.44e-0510212M39539
PathwayWP_LEPTIN_AND_ADIPONECTIN

ADIPOR1 ADIPOR2

9.44e-0510212MM15824
Pubmed

The human olfactory receptor gene family.

OR5C1 OR52B4 OR5M11 OR11A1 OR5G3 OR6K2 OR5B12 OR2G2

3.98e-0954126814983052
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR5C1 OR52B4 OR5M11 OR11A1 OR5G3 OR6K2 OR5B12

4.50e-0934026711875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR5C1 OR52B4 OR5M11 OR11A1 OR5G3 OR6K2 OR5B12

4.50e-0934026711802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR5C1 OR52B4 OR5M11 OR11A1 OR5G3 OR6K2 OR5B12

4.78e-0934326732295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR5C1 OR52B4 OR5M11 OR11A1 OR5G3 OR6K2 OR5B12

5.08e-0934626714611657
Pubmed

Adiponectin receptor-1 expression is decreased in the pancreas of obese mice.

ADIPOR1 ADIPOR2

5.37e-07226219062045
Pubmed

Cardiomyocyte-derived adiponectin is biologically active in protecting against myocardial ischemia-reperfusion injury.

ADIPOR1 ADIPOR2

5.37e-07226220028965
Pubmed

Lack of any prognostic relationship between adiponectin receptor (Adipo R1/R2) expression for early/advanced stage gastric cancer.

ADIPOR1 ADIPOR2

5.37e-07226224969908
Pubmed

AdipoR-increased intracellular ROS promotes cPLA2 and COX-2 expressions via activation of PKC and p300 in adiponectin-stimulated human alveolar type II cells.

ADIPOR1 ADIPOR2

5.37e-07226227288489
Pubmed

Adiponectin and adiponectin receptor in relation to colorectal cancer progression.

ADIPOR1 ADIPOR2

5.37e-07226221351255
Pubmed

Adiponectin receptor expression in gastric carcinoma: implications in tumor development and progression.

ADIPOR1 ADIPOR2

5.37e-07226223358721
Pubmed

Expression profiles of adiponectin receptors in mouse embryos.

ADIPOR1 ADIPOR2

5.37e-07226215939384
Pubmed

Arterial stiffness is associated with increased monocyte expression of adiponectin receptor mRNA and protein in patients with coronary artery disease.

ADIPOR1 ADIPOR2

5.37e-07226222534793
Pubmed

Expression and biologic significance of adiponectin receptors in papillary thyroid carcinoma.

ADIPOR1 ADIPOR2

5.37e-07226222907586
Pubmed

Characterisation of the adiponectin receptors: Differential cell-surface expression and temporal signalling profiles of AdipoR1 and AdipoR2 are regulated by the non-conserved N-terminal trunks.

ADIPOR1 ADIPOR2

5.37e-07226225892445
Pubmed

Adiponectin receptors form homomers and heteromers exhibiting distinct ligand binding and intracellular signaling properties.

ADIPOR1 ADIPOR2

5.37e-07226223255609
Pubmed

Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance.

ADIPOR1 ADIPOR2

5.37e-07226217716299
Pubmed

Low-abundant adiponectin receptors in visceral adipose tissue of humans and rats are further reduced in diabetic animals.

ADIPOR1 ADIPOR2

5.37e-07226220470935
Pubmed

Adipo-R1 and adipo-R2 expression in colorectal adenomas and carcinomas.

ADIPOR1 ADIPOR2

5.37e-07226225640382
Pubmed

Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism.

ADIPOR1 ADIPOR2

5.37e-07226215331527
Pubmed

Omental fat expression of adiponectin and adiponectin receptors in non-obese women with PCOS: a preliminary study.

ADIPOR1 ADIPOR2

5.37e-07226219909601
Pubmed

The expression and relationship of AdipoR1/R2 in gastric intestinal metaplasia.

ADIPOR1 ADIPOR2

5.37e-07226233851685
Pubmed

Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2.

ADIPOR1 ADIPOR2

5.37e-07226217459059
Pubmed

The role of AdipoR1 and AdipoR2 in liver fibrosis.

ADIPOR1 ADIPOR2

5.37e-07226229237572
Pubmed

Variations in adiponectin receptor genes and susceptibility to type 2 diabetes in women: a tagging-single nucleotide polymorphism haplotype analysis.

ADIPOR1 ADIPOR2

5.37e-07226217416799
Pubmed

Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects.

ADIPOR1 ADIPOR2

5.37e-07226228145500
Pubmed

Adiponectin receptor expression is elevated in colorectal carcinomas but not in gastrointestinal stromal tumors.

ADIPOR1 ADIPOR2

5.37e-07226218310295
Pubmed

The effect of renal transplantation on adiponectin and its isoforms and receptors.

ADIPOR1 ADIPOR2

5.37e-07226217697862
Pubmed

AdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice.

ADIPOR1 ADIPOR2

5.37e-07226233420419
Pubmed

Adiponectin receptor expression predicts favorable prognosis in cases of hepatocellular carcinoma.

ADIPOR1 ADIPOR2

5.37e-07226224619866
Pubmed

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.

ADIPOR1 ADIPOR2

5.37e-07226221186369
Pubmed

Expressions of adiponectin receptors in placenta and their correlation with preeclampsia.

ADIPOR1 ADIPOR2

5.37e-07226219487733
Pubmed

Polymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreans.

ADIPOR1 ADIPOR2

5.37e-07226218466348
Pubmed

Association of ADIPOR2 with liver function tests in type 2 diabetic subjects.

ADIPOR1 ADIPOR2

5.37e-07226218719649
Pubmed

Adiponectin receptors are expressed in hypothalamus and colocalized with proopiomelanocortin and neuropeptide Y in rodent arcuate neurons.

ADIPOR1 ADIPOR2

5.37e-07226218971219
Pubmed

Crystal structures of the human adiponectin receptors.

ADIPOR1 ADIPOR2

5.37e-07226225855295
Pubmed

Adiponectin receptor signaling on dendritic cells blunts antitumor immunity.

ADIPOR1 ADIPOR2

5.37e-07226225261236
Pubmed

Overexpression of adiponectin receptors potentiates the antiinflammatory action of subeffective dose of globular adiponectin in vascular endothelial cells.

ADIPOR1 ADIPOR2

5.37e-07226218988888
Pubmed

Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes.

ADIPOR1 ADIPOR2

5.37e-07226215105989
Pubmed

Involvement of AdipoR receptor in adiponectin-induced motility and alpha2beta1 integrin upregulation in human chondrosarcoma cells.

ADIPOR1 ADIPOR2

5.37e-07226219549705
Pubmed

Adiponectin receptors are downregulated in human gastric cancer.

ADIPOR1 ADIPOR2

5.37e-07226220336470
Pubmed

Opposing effects of adiponectin receptors 1 and 2 on energy metabolism.

ADIPOR1 ADIPOR2

5.37e-07226217327425
Pubmed

Divergent roles for adiponectin receptor 1 (AdipoR1) and AdipoR2 in mediating revascularization and metabolic dysfunction in vivo.

ADIPOR1 ADIPOR2

5.37e-07226224742672
Pubmed

Structural insights into adiponectin receptors suggest ceramidase activity.

ADIPOR1 ADIPOR2

5.37e-07226228329765
Pubmed

Localization of novel adiponectin receptor constructs.

ADIPOR1 ADIPOR2

5.37e-07226217118803
Pubmed

in vitro Anti-Proliferative Effect of Adiponectin on Human Endometriotic Stromal Cells through AdipoR1 and AdipoR2 Gene Receptor Expression.

ADIPOR1 ADIPOR2

5.37e-07226226459399
Pubmed

Macrophage polarization phenotype regulates adiponectin receptor expression and adiponectin anti-inflammatory response.

ADIPOR1 ADIPOR2

5.37e-07226225392268
Pubmed

Pattern of expression of adiponectin receptors in human liver and its relation to nonalcoholic steatohepatitis.

ADIPOR1 ADIPOR2

5.37e-07226218923878
Pubmed

Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.

ADIPOR1 ADIPOR2

5.37e-07226215918014
Pubmed

The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth.

ADIPOR1 ADIPOR2

5.37e-07226218842004
Pubmed

Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat.

ADIPOR1 ADIPOR2

5.37e-07226216205883
Pubmed

Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome.

ADIPOR1 ADIPOR2

5.37e-07226216700915
Pubmed

A monoclonal antibody activating AdipoR for type 2 diabetes and nonalcoholic steatohepatitis.

ADIPOR1 ADIPOR2

5.37e-07226237948516
Pubmed

Expression of adiponectin receptors and its possible implication in the human endometrium.

ADIPOR1 ADIPOR2

5.37e-07226216601138
Pubmed

AdipoR1 and 2 are expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin.

ADIPOR1 ADIPOR2

5.37e-07226222000082
Pubmed

Adiponectin regulate growth hormone secretion via adiponectin receptor mediated Ca(2+) signalling in rat somatotrophs in vitro.

ADIPOR1 ADIPOR2

5.37e-07226219500219
Pubmed

Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training.

ADIPOR1 ADIPOR2

5.37e-07226217878241
Pubmed

Regulation of adiponectin receptors in hepatocytes by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone.

ADIPOR1 ADIPOR2

5.37e-07226216609881
Pubmed

Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations.

ADIPOR1 ADIPOR2

5.37e-07226217216283
Pubmed

Dual action of adiponectin on insulin secretion in insulin-resistant mice.

ADIPOR1 ADIPOR2

5.37e-07226215358228
Pubmed

Regulation of adiponectin receptor gene expression in diabetic mice.

ADIPOR1 ADIPOR2

5.37e-07226215613685
Pubmed

Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1.

ADIPOR1 ADIPOR2

5.37e-07226225982881
Pubmed

Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population.

ADIPOR1 ADIPOR2

5.37e-07226216505255
Pubmed

Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study.

ADIPOR1 ADIPOR2

5.37e-07226216724230
Pubmed

Demonstration of adiponectin receptors 1 and 2 mRNA expression in human breast cancer cells.

ADIPOR1 ADIPOR2

5.37e-07226217123704
Pubmed

Expression, purification, crystallization, and preliminary X-ray crystallographic studies of the human adiponectin receptors, AdipoR1 and AdipoR2.

ADIPOR1 ADIPOR2

5.37e-07226225575462
Pubmed

The distribution of adiponectin receptors on human peripheral blood mononuclear cells.

ADIPOR1 ADIPOR2

5.37e-07226219120283
Pubmed

AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of adiponectin.

ADIPOR1 ADIPOR2

5.37e-07226230890562
Pubmed

Role of adiponectin receptors, AdipoR1 and AdipoR2, in the steroidogenesis of the human granulosa tumor cell line, KGN.

ADIPOR1 ADIPOR2

5.37e-07226219671624
Pubmed

The regulation of adiponectin receptors in human prostate cancer cell lines.

ADIPOR1 ADIPOR2

5.37e-07226216899222
Pubmed

Polymorphisms in adiponectin receptor genes are associated with lipodystrophy-related phenotypes in HIV-infected patients receiving antiretroviral therapy.

ADIPOR1 ADIPOR2

5.37e-07226226111083
Pubmed

Expression of adiponectin receptors in pancreatic beta cells.

ADIPOR1 ADIPOR2

5.37e-07226214651988
Pubmed

Upregulation of adiponectin receptor 1 and 2 mRNA and protein in adipose tissue and adipocytes in insulin-resistant women with polycystic ovary syndrome.

ADIPOR1 ADIPOR2

5.37e-07226217001470
Pubmed

Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings.

ADIPOR1 ADIPOR2

5.37e-07226236429712
Pubmed

Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins.

ADIPOR1 ADIPOR2

5.37e-07226232750056
Pubmed

Expression of adiponectin receptors in mouse adrenal glands and the adrenocortical Y-1 cell line: adiponectin regulates steroidogenesis.

ADIPOR1 ADIPOR2

5.37e-07226219878661
Pubmed

Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish.

ADIPOR1 ADIPOR2

5.37e-07226215983228
Pubmed

Variations in ADIPOR1 But Not ADIPOR2 are Associated With Hypertriglyceridemia and Diabetes in an Admixed Latin American Population.

ADIPOR1 ADIPOR2

5.37e-07226229145541
Pubmed

Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypes.

ADIPOR1 ADIPOR2

1.61e-06326218548168
Pubmed

Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells.

ADIPOR1 ADIPOR2

1.61e-06326216678125
Pubmed

Identification of adiponectin and its receptors in human osteoblast-like cells and association of T45G polymorphism in exon 2 of adiponectin gene with lumbar spine bone mineral density in Korean women.

ADIPOR1 ADIPOR2

1.61e-06326217054465
Pubmed

Differential effects of adiponectin in osteoblast-like cells.

ADIPOR1 ADIPOR2

1.61e-06326224673523
Pubmed

The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle.

ADIPOR1 ADIPOR2

1.61e-06326215757860
Pubmed

Adiponectin and its receptors modulate granulosa cell and cumulus cell functions, fertility, and early embryo development in the mouse and human.

ADIPOR1 ADIPOR2

1.61e-06326222633650
Pubmed

Adiponectin receptors are present in RANK-L-induced multinucleated osteoclast-like cells.

ADIPOR1 ADIPOR2

1.61e-06326223971629
Pubmed

Adiponectin-AdipoR1/2-APPL1 signaling axis suppresses human foam cell formation: differential ability of AdipoR1 and AdipoR2 to regulate inflammatory cytokine responses.

ADIPOR1 ADIPOR2

1.61e-06326222227293
Pubmed

Adiponectin levels and expression of adiponectin receptors in isolated monocytes from overweight patients with coronary artery disease.

ADIPOR1 ADIPOR2

1.61e-06326221284833
Pubmed

Adiponectin receptor binding proteins--recent advances in elucidating adiponectin signalling pathways.

ADIPOR1 ADIPOR2

1.61e-06326220875820
Pubmed

Hepatic adiponectin receptors (ADIPOR) 1 and 2 mRNA and their relation to insulin resistance in obese humans.

ADIPOR1 ADIPOR2

1.61e-06326220125105
Pubmed

Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice.

ADIPOR1 ADIPOR2

1.61e-06326221889885
Pubmed

The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes.

ADIPOR1 ADIPOR2

1.61e-06326229330340
Pubmed

Relationships of plasma adiponectin level and adiponectin receptors 1 and 2 gene expression to insulin sensitivity and glucose and fat metabolism in monozygotic and dizygotic twins.

ADIPOR1 ADIPOR2

1.61e-06326217426101
Pubmed

Evidence for decreased expression of APPL1 associated with reduced insulin and adiponectin receptors expression in PCOS patients.

ADIPOR1 ADIPOR2

1.61e-06326227075719
Pubmed

Adiponectin and its receptors are expressed in bone-forming cells.

ADIPOR1 ADIPOR2

1.61e-06326215454091
Pubmed

Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans.

ADIPOR1 ADIPOR2

1.61e-06326216955209
Pubmed

Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Quebec Family Study.

ADIPOR1 ADIPOR2

1.61e-06326217209173
Pubmed

Adiponectin at Physiologically Relevant Concentrations Enhances the Vasorelaxative Effect of Acetylcholine via Cav-1/AdipoR-1 Signaling.

ADIPOR1 ADIPOR2

1.61e-06326227023866
Pubmed

Direct role of adiponectin and adiponectin receptors in endometrial cancer: in vitro and ex vivo studies in humans.

ADIPOR1 ADIPOR2

1.61e-06326221980131
Pubmed

Regulation of adiponectin receptor R1 and R2 gene expression in adipocytes of C57BL/6 mice.

ADIPOR1 ADIPOR2

1.61e-06326215752770
Pubmed

Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity.

ADIPOR1 ADIPOR2

1.61e-06326215123605
InteractionGK5 interactions

MST1R GK5

2.61e-058202int:GK5
Cytoband11q12.1

OR5M11 OR5G3 OR5B12

1.04e-0416126311q12.1
CytobandEnsembl 112 genes in cytogenetic band chr11q12

OR5M11 OR5G3 OR5B12

9.62e-04345263chr11q12
GeneFamilyAdiponectin receptors|Progestin and adipoQ receptor family

ADIPOR1 ADIPOR2

1.55e-062232293
GeneFamilyOlfactory receptors, family 5

OR5C1 OR5M11 OR5G3 OR5B12

1.13e-05112234152
GeneFamilyProgestin and adipoQ receptor family

ADIPOR1 ADIPOR2

8.45e-0511232930
ToppCellCOPD-Epithelial-Basal|World / Disease state, Lineage and Cell class

RANBP17 CELSR1 MAST4

1.56e-041812636d8a886b4afe729f8a05b9c0f4ea9375de735da4
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

RANBP17 CELSR1 MAST4

1.66e-04185263cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CELSR1 MAST4 GK5

1.69e-04186263e83718fabb057100835d3357df407f283d23fe16
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CELSR1 MAST4 GK5

1.74e-041882634bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCellCOVID-19-Epithelial_cells|COVID-19 / group, cell type (main and fine annotations)

RANBP17 CELSR1 MAST4

1.74e-04188263c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCellIPF-Epithelial-Club|World / Disease state, Lineage and Cell class

RANBP17 CELSR1 MAST4

1.82e-041912633c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

RANBP17 CELSR1 MAST4

1.82e-04191263e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

RANBP17 CELSR1 MAST4

1.85e-04192263efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellEpithelial|World / Lineage, Cell type, age group and donor

RANBP17 CELSR1 MAST4

1.85e-04192263499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCellFetal_29-31_weeks-Epithelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RANBP17 CELSR1 MAST4

1.88e-04193263a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCellBronchial-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RANBP17 CELSR1 MAST4

2.06e-041992635f7da3eab58ace6cddb3179a415cd839d5767958
ToppCellParenchymal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RANBP17 CELSR1 MAST4

2.06e-041992635cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCellHematolymphoid-Endothelial-NOSTRIN---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

RANBP17 MAST4 ADIPOR2

2.09e-0420026368fce28690246895fd33354b30960ebcc31aa4cc
ToppCellHematolymphoid-Endothelial-NOSTRIN|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

RANBP17 MAST4 ADIPOR2

2.09e-04200263032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCellHematolymphoid-Endothelial-NOSTRIN-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

RANBP17 MAST4 ADIPOR2

2.09e-04200263376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCellHematolymphoid-Endothelial-NOSTRIN----L2-6|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

RANBP17 MAST4 ADIPOR2

2.09e-04200263878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCellMS-IIF-Lymphocyte-T/NK-ILC|IIF / Disease, condition lineage and cell class

MAST4 ADIPOR2 ZFP57

2.09e-04200263edb0b252e6ff9824908d1ff7d0d42710b00949c8
ToppCellHematolymphoid-Endothelial|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

RANBP17 MAST4 ADIPOR2

2.09e-042002637136936d05ab344a560cf159684c881063b5430d
ToppCellHematolymphoid-Endothelial-NOSTRIN--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

RANBP17 MAST4 ADIPOR2

2.09e-042002637fa54370221ed61bac0e09e6bcf1f3dff202a846
Diseasehyperinsulinism (biomarker_via_orthology)

ADIPOR1 ADIPOR2

6.61e-0515242DOID:2018 (biomarker_via_orthology)
Diseasemacular degeneration (is_implicated_in)

ADIPOR1 CRP

2.20e-0427242DOID:4448 (is_implicated_in)
Diseaseobesity (biomarker_via_orthology)

ADIPOR1 ADIPOR2 CRP

2.27e-04147243DOID:9970 (biomarker_via_orthology)
DiseaseSubfertility, Female

ADIPOR1 ADIPOR2

2.37e-0428242C0341869
DiseaseSterility, Postpartum

ADIPOR1 ADIPOR2

2.37e-0428242C0038279
DiseaseFemale sterility

ADIPOR1 ADIPOR2

2.37e-0428242C0917730
DiseaseFemale infertility

ADIPOR1 ADIPOR2

2.37e-0428242C0021361
DiseaseC-reactive protein measurement

RANBP17 MST1R LLGL1 GK5 DNAH17 CRP

3.29e-041206246EFO_0004458
Diseasealcohol consumption measurement

RANBP17 MST1R MAST4 TAS2R38 GK5 BIRC6

3.85e-041242246EFO_0007878
Diseaseresponse to serotonin-norephinephrine reuptake inhibitor

GK5 BIRC6

3.93e-0436242EFO_0006325
Diseaseend stage renal disease (biomarker_via_orthology)

ADIPOR1 ADIPOR2

6.70e-0447242DOID:783 (biomarker_via_orthology)
DiseaseKidney Failure, Chronic

ADIPOR1 CRP

6.99e-0448242C0022661
Diseaseupper aerodigestive tract neoplasm

OR11A1 BIRC6 ZFP57

1.02e-03246243EFO_0004284
Diseaseaggressive behaviour measurement, ADHD symptom measurement

MST1R BIRC6

1.40e-0368242EFO_0007826, EFO_0007860
Diseaseobesity (is_marker_for)

ADIPOR1 CRP

3.05e-03101242DOID:9970 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
VRSLASFCFSHISSS

BIRC6

3636

Q9NR09
FTREAASRTFSSLHV

ALG5

241

Q9Y673
RFHFTISLTFATQER

CELSR1

1461

Q9NYQ6
HSLSDFRCRTTFYTA

RANBP17

656

Q9H2T7
SFRACFKSIFRIHTE

ADIPOR2

131

Q86V24
RTAFSTCVSHFIVFS

OR6K2

236

Q8NGY2
FTSRIIDFFTVHSTR

LLGL1

336

Q15334
LTFRLTFCRSSVINH

OR5M11

161

Q96RB7
RRAFSTCSSHLAVVT

OR11A1

236

Q9GZK7
LSHLSFLYRCFTSSV

OR2G2

66

Q8NGZ5
FRACFKSIFRIHTET

ADIPOR1

121

Q96A54
LDRCITQLFFIHSTF

OR52B4

96

Q8NGK2
TFRLSFCRSNVVEHF

OR5B12

161

Q96R08
FVHTTLTFRLSFCRS

OR5C1

161

Q8NGR4
TSLFIARSFRHCTAS

CKAP5

416

Q14008
SFTIDSRLQRHFCVF

DNAH17

2576

Q9UFH2
FTVCLHFYTELSSTR

CRP

51

P02741
FSSCSHRFSKVFSSI

MAST4

901

O15021
SSCRVLHFFTRSKRL

GK5

141

Q6ZS86
FFLRHLSFVDICSSS

OR5G3

61

P0C626
CFFSRPHFTVTTVLF

TAS2R38

161

P59533
FHCSKSFSSFSRLVR

ZFP57

331

Q9NU63
LCFSRDTSVLSHFAF

TBC1D19

321

Q8N5T2
SCRHFPLLVSSSFSR

MST1R

421

Q04912
NSRRFNHTCLTFTTR

ELFN2

366

Q5R3F8
LSVLFLRTFQFLCSH

GEMIN4

911

P57678