Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Glyco_hormone_CN	CCN2 MUC5AC	5.33e-04	15	43	2	IPR006208
Domain	Cys_knot	CCN2 MUC5AC	5.33e-04	15	43	2	PF00007
Domain	CTCK_1	CCN2 MUC5AC	7.74e-04	18	43	2	PS01185
Domain	CT	CCN2 MUC5AC	1.16e-03	22	43	2	SM00041
Domain	Cys_knot_C	CCN2 MUC5AC	1.50e-03	25	43	2	IPR006207
Domain	CTCK_2	CCN2 MUC5AC	1.50e-03	25	43	2	PS01225
Domain	VWC	CCN2 MUC5AC	1.88e-03	28	43	2	PF00093
Domain	VWFC_1	CCN2 MUC5AC	3.10e-03	36	43	2	PS01208
Domain	Pkinase_C	RPS6KA4 LATS2	3.28e-03	37	43	2	IPR017892
Domain	VWC	CCN2 MUC5AC	3.45e-03	38	43	2	SM00214
Domain	VWFC_2	CCN2 MUC5AC	3.45e-03	38	43	2	PS50184
Domain	Pkinase_C	RPS6KA4 LATS2	4.20e-03	42	43	2	PF00433
Domain	VWF_dom	CCN2 MUC5AC	4.20e-03	42	43	2	IPR001007
Domain	Sushi	PAPPA2 TPO	6.38e-03	52	43	2	PF00084
Domain	CCP	PAPPA2 TPO	6.87e-03	54	43	2	SM00032
Domain	SUSHI	PAPPA2 TPO	7.37e-03	56	43	2	PS50923
Domain	AGC-kinase_C	RPS6KA4 LATS2	7.37e-03	56	43	2	IPR000961
Domain	AGC_KINASE_CTER	RPS6KA4 LATS2	7.37e-03	56	43	2	PS51285
Domain	S_TK_X	RPS6KA4 LATS2	7.37e-03	56	43	2	SM00133
Domain	Channel_four-helix_dom	CACNA1F KCNC2	7.63e-03	57	43	2	IPR027359
Domain	-	CACNA1F KCNC2	7.63e-03	57	43	2	1.20.120.350
Domain	Sushi_SCR_CCP_dom	PAPPA2 TPO	7.63e-03	57	43	2	IPR000436
Pubmed	CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation.	CCN2 ARHGEF7	2.45e-05	6	45	2	23175185
Pubmed	Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.	MED14 MED13	5.86e-05	9	45	2	8710870
Pubmed	A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression.	MED14 MED13	7.32e-05	10	45	2	12218053
Pubmed	HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.	MED14 MED13	7.32e-05	10	45	2	23746844
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MED14 HIVEP3 DGKQ NLGN2 LATS2 MED13 USP40 HECTD4	7.68e-05	1105	45	8	35748872
Pubmed	Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos.	FUT4 GP1BB	8.94e-05	11	45	2	20876651
Pubmed	Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice.	RBM14 MUC5AC	8.94e-05	11	45	2	21444682
Pubmed	A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction.	MED14 MED13	1.07e-04	12	45	2	23563140
Pubmed	A novel docking site on Mediator is critical for activation by VP16 in mammalian cells.	MED14 MED13	1.27e-04	13	45	2	14657022
Pubmed	The Hippo pathway regulates Wnt/beta-catenin signaling.	DVL3 LATS2	1.27e-04	13	45	2	20412773
Pubmed	CDK8 is a positive regulator of transcriptional elongation within the serum response network.	MED14 MED13	1.27e-04	13	45	2	20098423
Pubmed	A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.	MED14 MED13	1.47e-04	14	45	2	10024883
Pubmed	DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.	CCN2 LATS2	1.47e-04	14	45	2	28087714
Pubmed	Structure, function, and activator-induced conformations of the CRSP coactivator.	MED14 MED13	1.47e-04	14	45	2	11834832
Pubmed	Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.	MED14 MED13	1.70e-04	15	45	2	18418385
Pubmed	The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs.	MED14 MED13	1.94e-04	16	45	2	10882111
Pubmed	Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae.	CCN2 PAX1	1.94e-04	16	45	2	27381226
Pubmed	Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.	MED14 MED13	2.20e-04	17	45	2	10235266
Pubmed	Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.	MED14 MED13	2.47e-04	18	45	2	10198638
Pubmed	The protein interaction landscape of the human CMGC kinase group.	RBM14 MED14 OBSL1 RPS6KA4 TROAP MED13	2.62e-04	695	45	6	23602568
Pubmed	An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.	MED14 MED13	2.76e-04	19	45	2	16799563
Pubmed	Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.	MED14 MED13	3.06e-04	20	45	2	15340084
Pubmed	ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.	RBM14 MED14 MED13	3.66e-04	107	45	3	20508642
Pubmed	Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers.	CCN2 RBBP8	3.72e-04	22	45	2	27117402
Pubmed	The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro.	MED14 MED13	3.72e-04	22	45	2	11867769
Pubmed	Composite co-activator ARC mediates chromatin-directed transcriptional activation.	MED14 MED13	4.07e-04	23	45	2	10235267
Pubmed	Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity.	RBM14 TROAP	4.07e-04	23	45	2	22792062
Pubmed	Ezh2 represses the basal cell lineage during lung endoderm development.	FUT4 MUC5AC	4.44e-04	24	45	2	25516972
Pubmed	Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade.	CCN2 LATS2	4.82e-04	25	45	2	30912742
Pubmed	Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network.	MED14 MED13	5.22e-04	26	45	2	34506481
Pubmed	DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.	VAPA OBSL1 TROAP	5.37e-04	122	45	3	30773093
Pubmed	Lats1 and Lats2 are required for the maintenance of multipotency in the Müllerian duct mesenchyme.	CCN2 LATS2	5.63e-04	27	45	2	31575647
Pubmed	A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth.	CCN2 LATS2	6.06e-04	28	45	2	25912685
Pubmed	A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.	MED14 MED13	6.50e-04	29	45	2	14638676
Pubmed	LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.	CCN2 LATS2	6.50e-04	29	45	2	27358050
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	RBM14 ARHGEF7 ICAM5	6.90e-04	133	45	3	15144186
Pubmed	Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.	ADAM2 MUC5AC	6.96e-04	30	45	2	17882221
Pubmed	The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.	MED14 MED13	7.43e-04	31	45	2	23322298
Pubmed	Lats1/2 inactivation reveals Hippo function in alveolar type I cell differentiation during lung transition to air breathing.	CCN2 LATS2	7.43e-04	31	45	2	30305289
Pubmed	Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate.	CCN2 LATS2	7.43e-04	31	45	2	36362374
Pubmed	The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways.	FUT4 MUC5AC	8.43e-04	33	45	2	23213461
Pubmed	MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.	MED14 MED13	8.94e-04	34	45	2	15989967
Pubmed	MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons.	PAPPA2 CCN2	9.48e-04	35	45	2	22407321
Pubmed	YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme.	CCN2 LATS2	1.00e-03	36	45	2	28943241
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	RBM14 TROAP RBBP8	1.02e-03	152	45	3	38360978
Pubmed	The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.	ARHGEF7 RBBP8	1.06e-03	37	45	2	8076819
Pubmed	Sequence-ready physical map of the mouse chromosome 16 region with conserved synteny to the human velocardiofacial syndrome region on 22q11.2.	DVL3 GP1BB	1.06e-03	37	45	2	10337614
Pubmed	Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.	MED14 MED13	1.18e-03	39	45	2	38690566
Pubmed	Assessment of community efforts to advance network-based prediction of protein-protein interactions.	DVL3 VAPA KPRP DGKQ NDUFAF3	1.29e-03	630	45	5	36949045
GeneFamily	Cyclins\|Mediator complex	MED14 MED13	1.45e-03	33	31	2	1061
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	PAPPA2 TPO	4.28e-03	57	31	2	1179
Disease	Malignant neoplasm of breast	DVL3 MED14 XIRP1 KCNT2 RCCD1 ICAM5 SH2D3A	8.50e-04	1074	43	7	C0006142
Disease	coffee consumption	YLPM1 HECTD4	1.00e-03	32	43	2	EFO_0004330
Disease	neurodegenerative disease (implicated_via_orthology)	DVL3 VAPA LATS2	1.24e-03	145	43	3	DOID:1289 (implicated_via_orthology)
Disease	complement factor H measurement	HIVEP3 KCNT2	1.64e-03	41	43	2	EFO_0008097
Disease	complement factor H-related protein 4 measurement	TPO KCNT2	2.34e-03	49	43	2	EFO_0600091
Disease	pulmonary fibrosis (biomarker_via_orthology)	CCN2 MUC5AC	2.43e-03	50	43	2	DOID:3770 (biomarker_via_orthology)
Disease	cystic fibrosis (is_marker_for)	ADRB3 MUC5AC	3.71e-03	62	43	2	DOID:1485 (is_marker_for)
Disease	Coronary Arteriosclerosis	HHIPL1 HECTD4	4.07e-03	65	43	2	C0010054
Disease	Coronary Artery Disease	HHIPL1 HECTD4	4.07e-03	65	43	2	C1956346

Protein segments in the cluster

Peptide	Gene	Start	Entry
PRRYCVRPNSGIIDP	VAPA	56	Q9P0L0
DLDPCPRPKRRQPYN	RBBP8	871	Q99708
FPPVAIPARLPERRY	ADAM2	661	Q99965
RYRLACPEPSVAILP	DGKQ	661	P52824
RPAPPLRPSAALCYK	ARHGEF7	656	Q14155
RLPPEPCAAARPALF	ADRB3	366	P13945
PRGCFTLPRSEPIRP	DVL3	341	Q92997
PRAPFYRPLAPELRA	RCCD1	146	A6NED2
PLRRSPPRASYVAPL	RBM14	216	Q96PK6
PPCFLRFPRPVRVVS	OBSL1	11	O75147
PPCSVLLPPHRAQRY	CACNA1F	1766	O60840
YNSPCPLRRSRSPIP	KCNC2	621	Q96PR1
FRPPFRPTQPLRLCA	HHIPL1	26	Q96JK4
RRCPPPPYPKHLLLR	LATS2	511	Q9NRM7
RDSAPRPPPDCRLRF	FUT4	201	P22083
APYRDLRCVAPPALR	GP1BB	111	P13224
AYVPPLSLPPCPRER	HMGN2P46	61	Q86SG4
PDARIPERRPYTVPF	KIF27	571	Q86VH2
APRIPRVLAPGIYVC	ICAM5	631	Q9UMF0
RAYLPFVPPRAPAAC	TPO	361	P07202
SRRILKCSPPFPPRI	RPS6KA4	251	O75676
IERRVYPCSPTTPVP	MUC5AC	1311	P98088
SEVPPLPPRYRFRDL	KCNT2	6	Q6UVM3
RMLYRDCARPPPPPL	HECTD4	1916	Q9Y4D8
CSLRLPPEPERPRFA	GPR78	156	Q96P69
YPRLPTCIRDKIIPP	MED14	166	O60244
SVAYTDCPSRPRPPR	PAX1	441	P15863
SGCRPVRYQVLRDPP	PAPPA2	1046	Q9BXP8
PLCPRERPRHNFPVV	CEFIP	1221	Q711Q0
LSPRERPCSAIYPTP	DOCK4	1716	Q8N1I0
RRPLDPLDPCLYRGL	B3GNT4	331	Q9C0J1
VRLPSPDCPFPRRVK	CCN2	141	P29279
LPPPRRLQLFPRSCS	KPRP	256	Q5T749
PPRRFEPCSSSYLPL	KPRP	271	Q5T749
TPPRRSEPIYNSRCP	KPRP	296	Q5T749
RPLPRQLSEPCLYPE	KPRP	421	Q5T749
CLYPEPLPALRPTPR	KPRP	431	Q5T749
LRPACPPDYTLALRR	NLGN2	761	Q8NFZ4
VCPPLRSRAYTPPED	MRPL50	51	Q8N5N7
PYPVCRVDPIKPRDS	SAXO1	111	Q8IYX7
PDRPECIRLYAPPFI	MED13	1751	Q9UHV7
IIRARPPPFLFCPLS	TEPP	16	Q6URK8
YRARPSLRCPPVELP	NDUFAF3	11	Q9BU61
ERPPTYCELVPRVPS	SH2D3A	226	Q9BRG2
PPARVAPPERRKCFL	HIVEP3	1031	Q5T1R4
CPPAEPRPLESYCRI	TROAP	581	Q12815
PRPLESYCRIEPEIP	TROAP	586	Q12815
RVRATSVLPRYGPPC	SPATA7	6	Q9P0W8
PLPPLPPLDRYRDDR	YLPM1	1336	P49750
LRPRSPSCPLPRYRT	PRR30	256	Q53SZ7
RPPEARANPRYGVPC	USP40	486	Q9NVE5
REYLCPPRVLPSSRD	XIRP1	1651	Q702N8