Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	basal RNA polymerase II transcription machinery binding	GTF2E2 AGO1 CTR9 PAF1	1.17e-04	66	76	4	GO:0001099
GeneOntologyMolecularFunction	basal transcription machinery binding	GTF2E2 AGO1 CTR9 PAF1	1.17e-04	66	76	4	GO:0001098
GeneOntologyMolecularFunction	RNA polymerase II complex binding	AGO1 CTR9 PAF1	4.39e-04	39	76	3	GO:0000993
GeneOntologyMolecularFunction	RNA polymerase core enzyme binding	AGO1 CTR9 PAF1	6.70e-04	45	76	3	GO:0043175
GeneOntologyMolecularFunction	structural constituent of postsynaptic actin cytoskeleton	POTEE POTEF	7.69e-04	11	76	2	GO:0098973
GeneOntologyMolecularFunction	gamma-catenin binding	APC CTNNA1	9.21e-04	12	76	2	GO:0045295
GeneOntologyBiologicalProcess	siRNA-mediated post-transcriptional gene silencing	AGO1 AGO4	8.21e-05	4	77	2	GO:0140766
GeneOntologyBiologicalProcess	siRNA-mediated gene silencing by mRNA destabilization	AGO1 AGO4	8.21e-05	4	77	2	GO:0090625
GeneOntologyBiologicalProcess	prostate gland development	HOXA10 HOXA11 CD44 APC	8.50e-05	62	77	4	GO:0030850
GeneOntologyCellularComponent	Cdc73/Paf1 complex	CTR9 PAF1	2.64e-04	7	75	2	GO:0016593
GeneOntologyCellularComponent	cytoplasmic ribonucleoprotein granule	FLG LARP4B AGO1 AGO4 TNRC6C PPP6R2	4.11e-04	269	75	6	GO:0036464
GeneOntologyCellularComponent	RISC-loading complex	AGO1 AGO4	5.61e-04	10	75	2	GO:0070578
GeneOntologyCellularComponent	ribonucleoprotein granule	FLG LARP4B AGO1 AGO4 TNRC6C PPP6R2	5.79e-04	287	75	6	GO:0035770
GeneOntologyCellularComponent	9+2 non-motile cilium	KNCN GRXCR1	1.12e-03	14	75	2	GO:0097732
GeneOntologyCellularComponent	kinocilium	KNCN GRXCR1	1.12e-03	14	75	2	GO:0060091
Domain	ANK	POTEE POTEM POTEF POTEG ANKIB1 TNKS POTEB2 POTEH POTEB	7.19e-07	251	75	9	SM00248
Domain	ANK_REPEAT	POTEE POTEM POTEF POTEG ANKIB1 TNKS POTEB2 POTEH POTEB	7.68e-07	253	75	9	PS50088
Domain	Ankyrin_rpt-contain_dom	POTEE POTEM POTEF POTEG ANKIB1 TNKS POTEB2 POTEH POTEB	7.94e-07	254	75	9	IPR020683
Domain	ANK_REP_REGION	POTEE POTEM POTEF POTEG ANKIB1 TNKS POTEB2 POTEH POTEB	7.94e-07	254	75	9	PS50297
Domain	Ankyrin_rpt	POTEE POTEM POTEF POTEG ANKIB1 TNKS POTEB2 POTEH POTEB	1.03e-06	262	75	9	IPR002110
Domain	Ank	POTEE POTEM POTEF POTEG ANKIB1 TNKS POTEH POTEB	3.64e-06	228	75	8	PF00023
Domain	-	POTEE POTEM POTEF POTEG ANKIB1 TNKS POTEB2 POTEH	6.76e-06	248	75	8	1.25.40.20
Domain	Ank_2	POTEE POTEM POTEF POTEG TNKS POTEB2 POTEH	2.48e-05	215	75	7	PF12796
Domain	Argonaute_N	AGO1 AGO4	9.50e-05	4	75	2	IPR032474
Domain	Argonaute_Mid_dom	AGO1 AGO4	9.50e-05	4	75	2	IPR032473
Domain	ArgoL2	AGO1 AGO4	9.50e-05	4	75	2	IPR032472
Domain	ArgoN	AGO1 AGO4	9.50e-05	4	75	2	PF16486
Domain	ArgoMid	AGO1 AGO4	9.50e-05	4	75	2	PF16487
Domain	ArgoL2	AGO1 AGO4	9.50e-05	4	75	2	PF16488
Domain	UBA-like	USP28 UBQLN3 TNRC6C OTUD7B	1.27e-04	64	75	4	IPR009060
Domain	DUF1785	AGO1 AGO4	1.58e-04	5	75	2	SM01163
Domain	ArgoL1	AGO1 AGO4	2.36e-04	6	75	2	PF08699
Domain	ArgoL1	AGO1 AGO4	2.36e-04	6	75	2	IPR014811
Domain	PIWI	AGO1 AGO4	4.39e-04	8	75	2	PS50822
Domain	Piwi	AGO1 AGO4	4.39e-04	8	75	2	SM00950
Domain	Piwi	AGO1 AGO4	4.39e-04	8	75	2	IPR003165
Domain	Piwi	AGO1 AGO4	4.39e-04	8	75	2	PF02171
Domain	PAZ	AGO1 AGO4	5.62e-04	9	75	2	PS50821
Domain	PAZ	AGO1 AGO4	5.62e-04	9	75	2	SM00949
Domain	PAZ_dom	AGO1 AGO4	5.62e-04	9	75	2	IPR003100
Domain	PAZ	AGO1 AGO4	5.62e-04	9	75	2	PF02170
Domain	IBR	FBXO43 ANKIB1	1.40e-03	14	75	2	SM00647
Domain	IBR	FBXO43 ANKIB1	1.40e-03	14	75	2	PF01485
Domain	IBR_dom	FBXO43 ANKIB1	1.62e-03	15	75	2	IPR002867
Domain	Actin_CS	POTEE POTEF	1.84e-03	16	75	2	IPR004001
Domain	ACTINS_2	POTEE POTEF	2.08e-03	17	75	2	PS00432
Domain	Actin/actin-like_CS	POTEE POTEF	2.34e-03	18	75	2	IPR020902
Domain	ACTINS_ACT_LIKE	POTEE POTEF	2.60e-03	19	75	2	PS01132
Domain	UIM	USP28 ANKIB1	3.18e-03	21	75	2	SM00726
Domain	UIM	USP28 ANKIB1	4.15e-03	24	75	2	PS50330
Domain	UIM_dom	USP28 ANKIB1	4.50e-03	25	75	2	IPR003903
Domain	S_100	FLG CRNN	5.23e-03	27	75	2	PF01023
Domain	S100_Ca-bd_sub	FLG CRNN	5.62e-03	28	75	2	IPR013787
Domain	S_100	FLG CRNN	5.62e-03	28	75	2	SM01394
Domain	UBA	UBQLN3 TNRC6C	6.44e-03	30	75	2	SM00165
Domain	Actin	POTEE POTEF	6.86e-03	31	75	2	IPR004000
Domain	Actin	POTEE POTEF	6.86e-03	31	75	2	PF00022
Domain	ACTIN	POTEE POTEF	6.86e-03	31	75	2	SM00268
Domain	UBA	UBQLN3 TNRC6C	9.18e-03	36	75	2	PF00627
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	AGO1 AGO4 TNRC6C	1.20e-06	7	47	3	M46421
Pathway	REACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION	AGO1 AGO4 TNRC6C	2.88e-06	9	47	3	M27810
Pathway	REACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION	AGO1 AGO4 TNRC6C	2.88e-06	9	47	3	M46436
Pathway	REACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION	AGO1 AGO4 CTNNA1 TNRC6C	3.64e-06	32	47	4	M48012
Pathway	REACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS	AGO1 AGO4 TNRC6C	4.10e-06	10	47	3	M48013
Pathway	REACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION	AGO1 AGO4 TNRC6C	9.70e-06	13	47	3	M46434
Pathway	REACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY	AGO1 AGO4 TNRC6C	2.29e-05	17	47	3	M27788
Pathway	REACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS	AGO1 AGO4 TNRC6C	3.24e-05	19	47	3	M48238
Pathway	REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS	AGO1 AGO4 CTNNA1 TNRC6C	4.03e-05	58	47	4	M11980
Pathway	REACTOME_TGFBR3_EXPRESSION	AGO1 AGO4 TNRC6C	1.07e-04	28	47	3	M48253
Pathway	BIOCARTA_DICER_PATHWAY	AGO1 AGO4	1.08e-04	5	47	2	M22079
Pathway	REACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY	AGO1 AGO4 TNRC6C	1.61e-04	32	47	3	M27900
Pathway	REACTOME_MICRORNA_MIRNA_BIOGENESIS	AGO1 AGO4	1.62e-04	6	47	2	MM14818
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	AGO1 AGO4	1.62e-04	6	47	2	MM15083
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4	AGO1 AGO4 TNRC6C	1.93e-04	34	47	3	M46422
Pathway	REACTOME_NUCLEAR_EVENTS_STIMULATED_BY_ALK_SIGNALING_IN_CANCER	AGO1 AGO4 TNRC6C	2.11e-04	35	47	3	M42525
Pathway	REACTOME_ONCOGENE_INDUCED_SENESCENCE	AGO1 AGO4 TNRC6C	2.11e-04	35	47	3	M27190
Pathway	REACTOME_CELL_CELL_JUNCTION_ORGANIZATION	AGO1 AGO4 CTNNA1 TNRC6C	2.25e-04	90	47	4	M820
Pathway	REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX	AGO1 AGO4 TNRC6C	2.49e-04	37	47	3	M29790
Pathway	REACTOME_SIGNALING_BY_ALK_IN_CANCER	TPR AGO1 AGO4 TNRC6C	2.55e-04	93	47	4	M42521
Pathway	REACTOME_MITF_M_DEPENDENT_GENE_EXPRESSION	ARID1B AGO1 AGO4 TNRC6C	2.77e-04	95	47	4	M48268
Pathway	REACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS	AGO1 AGO4	3.01e-04	8	47	2	MM15082
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_VENTX	AGO1 AGO4 TNRC6C	3.39e-04	41	47	3	M29748
Pathway	REACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS	AGO1 AGO4	3.86e-04	9	47	2	M27340
Pathway	REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING	AGO1 AGO4 TNRC6C	5.08e-04	47	47	3	M29777
Pathway	REACTOME_GENE_SILENCING_BY_RNA	TPR AGO1 AGO4	5.75e-04	49	47	3	MM14837
Pathway	REACTOME_SIGNALING_BY_TGFBR3	AGO1 AGO4 TNRC6C	5.75e-04	49	47	3	M48250
Pathway	REACTOME_CELL_JUNCTION_ORGANIZATION	AGO1 AGO4 CTNNA1 TNRC6C	6.10e-04	117	47	4	M19248
Pathway	REACTOME_SIGNALING_BY_WNT	AGO1 AGO4 APC TNKS TNRC6C RUNX3	7.52e-04	330	47	6	M7847
Pathway	KEGG_MEDICUS_VARIANT_MLL_ENL_FUSION_TO_TRANSCRIPTIONAL_ACTIVATION	HOXA10 HOXA11	8.29e-04	13	47	2	M47440
Pathway	REACTOME_MITF_M_REGULATED_MELANOCYTE_DEVELOPMENT	ARID1B AGO1 AGO4 TNRC6C	1.10e-03	137	47	4	M48232
Pathway	REACTOME_CA2_PATHWAY	AGO1 AGO4 TNRC6C	1.14e-03	62	47	3	M27321
Pathway	REACTOME_PTEN_REGULATION	AGO1 AGO4 TNKS TNRC6C	1.16e-03	139	47	4	M27646
Pathway	REACTOME_GENE_SILENCING_BY_RNA	TPR AGO1 AGO4 TNRC6C	1.16e-03	139	47	4	M715
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2	AGO1 AGO4 TNRC6C	1.20e-03	63	47	3	M27862
Pathway	WP_ENDODERM_DIFFERENTIATION	CTR9 APC TNRC6C PAF1	1.29e-03	143	47	4	M39591
Pathway	WP_REGULATION_OF_WNT_BCATENIN_SIGNALING_BY_SMALL_MOLECULE_COMPOUNDS	APC TNKS	1.43e-03	17	47	2	M39525
Pathway	WP_2Q211_COPY_NUMBER_VARIATION_SYNDROME	POTEE APC	1.61e-03	18	47	2	M45539
Pathway	REACTOME_CELL_CELL_COMMUNICATION	AGO1 AGO4 CTNNA1 TNRC6C	1.74e-03	155	47	4	M522
Pathway	REACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS	GTF2E2 CTR9 PAF1	2.47e-03	81	47	3	M865
Pathway	REACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS	GTF2E2 CTR9 PAF1	2.65e-03	83	47	3	MM15314
Pathway	REACTOME_TP53_REGULATES_METABOLIC_GENES	AGO1 AGO4 TNRC6C	2.74e-03	84	47	3	M27495
Pathway	REACTOME_MICRORNA_MIRNA_BIOGENESIS	AGO1 AGO4	3.11e-03	25	47	2	M712
Pathway	WP_WARBURG_EFFECT_MODULATED_BY_DEUBIQUITINATING_ENZYMES_AND_THEIR_SUBSTRATES	USP28 OTUD7B	3.36e-03	26	47	2	M48054
Pathway	WP_OXIDATIVE_STRESS_AND_REDOX_PATHWAY	CD44 GRXCR1 SOD3	3.54e-03	92	47	3	MM15823
Pathway	REACTOME_MAPK6_MAPK4_SIGNALING	AGO1 AGO4 TNRC6C	3.65e-03	93	47	3	M27572
Pathway	REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION	AGO1 AGO4 TNRC6C	4.00e-03	96	47	3	M27792
Pathway	REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS	TPR AGO1 AGO4 APC TNKS TNRC6C	4.21e-03	464	47	6	M27547
Pubmed	Two novel transcripts encoding two Ankyrin repeat containing proteins have preponderant expression during the mouse spermatogenesis.	POTEM POTEG POTEB2 POTEH POTEB	2.79e-13	6	77	5	17171436
Pubmed	Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.	POTEE POTEG POTEH POTEB	7.73e-10	7	77	4	15276201
Pubmed	Identification of a novel actin isoform in hepatocellular carcinoma.	POTEE POTEM POTEF POTEG	2.98e-08	15	77	4	16824795
Pubmed	Identification and characterization of TSAP, a novel gene specifically expressed in testis during spermatogenesis.	POTEM POTEH POTEB	4.17e-08	4	77	3	17342726
Pubmed	The Vertebrate Genome Annotation browser 10 years on.	POTEE POTEM POTEF POTEG POTEB2 POTEH POTEB	7.97e-08	163	77	7	24316575
Pubmed	Functional dissection of the human TNRC6 (GW182-related) family of proteins.	AGO1 AGO4 TNRC6C	3.63e-07	7	77	3	19470757
Pubmed	The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.	AGO1 AGO4 TNRC6C	3.63e-07	7	77	3	19383768
Pubmed	POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.	POTEB2 POTEH POTEB	5.80e-07	8	77	3	12475935
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	HMBOX1 HOXA10 HOXA11 EPPK1 EVPLL NOM1 HIC2 PAF1 RUNX3 ADD1	6.50e-07	583	77	10	29844126
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	FAM171A1 TPR AGO1 MYCBP2 USP28 APC TNKS LRRTM1 CTNNA1 PAF1 PPP6R2 ADD1	1.33e-06	963	77	12	28671696
Pubmed	The role of HOX genes in human implantation.	HOXA10 HOXA11	4.84e-06	2	77	2	15731295
Pubmed	The Importance of AGO 1 and 4 in Post-Transcriptional Gene Regulatory Function of tRF5-GluCTC, an Respiratory Syncytial Virus-Induced tRNA-Derived RNA Fragment.	AGO1 AGO4	4.84e-06	2	77	2	33233493
Pubmed	Expression of HOXA-10 and HOXA-11 in the endometria of women with idiopathic infertility.	HOXA10 HOXA11	4.84e-06	2	77	2	21526497
Pubmed	Laparoscopic Ovarian Drilling Improves Endometrial Homeobox Gene Expression in PCOS.	HOXA10 HOXA11	4.84e-06	2	77	2	32046414
Pubmed	The role of abnormal hypermethylation of the HOXA10 and HOXA11 promoters in implantation failures in IVF programs.	HOXA10 HOXA11	4.84e-06	2	77	2	31532317
Pubmed	Laparoscopic endometrioma resection increases peri-implantation endometrial HOXA-10 and HOXA-11 mRNA expression.	HOXA10 HOXA11	4.84e-06	2	77	2	26056923
Pubmed	The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse.	CD44 APC	4.84e-06	2	77	2	18085615
Pubmed	Endometrial Injury Upregulates Expression of Receptivity Genes in Women with Implantation Failure.	HOXA10 HOXA11	4.84e-06	2	77	2	36900953
Pubmed	A primate-specific POTE-actin fusion protein plays a role in apoptosis.	POTEE POTEF	4.84e-06	2	77	2	19669888
Pubmed	HOXA-11 mediated dysregulation of matrix remodeling during implantation window in women with endometriosis.	HOXA10 HOXA11	4.84e-06	2	77	2	23979130
Pubmed	Overexpression of HOXA10 promotes gastric cancer cells proliferation and HOXA10(+)/CD44(+) is potential prognostic biomarker for gastric cancer.	HOXA10 CD44	4.84e-06	2	77	2	26552644
Pubmed	The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility.	HOXA10 HOXA11	4.84e-06	2	77	2	26552702
Pubmed	HoxA10 and HoxA11 Regulate the Expression of Contraction-Associated Proteins and Contribute to Regionalized Myometrium Phenotypes in Women.	HOXA10 HOXA11	4.84e-06	2	77	2	28372536
Pubmed	Ly6 family member C4.4A binds laminins 1 and 5, associates with galectin-3 and supports cell migration.	CD44 LYPD3	4.84e-06	2	77	2	15729693
Pubmed	Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation.	CTR9 PAF1	4.84e-06	2	77	2	30228257
Pubmed	Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling.	CD44 APC	4.84e-06	2	77	2	23318432
Pubmed	Effects of Echinococcus multilocularis miR-71 mimics on murine macrophage RAW264.7 cells.	AGO1 AGO4	4.84e-06	2	77	2	26995025
Pubmed	HOX A10 and HOX A11 mutation scan in congenital malformations of the female genital tract.	HOXA10 HOXA11	4.84e-06	2	77	2	20457539
Pubmed	Macrophage-Associated Osteoactivin/GPNMB Mediates Mesenchymal Stem Cell Survival, Proliferation, and Migration Via a CD44-Dependent Mechanism.	CD44 GPNMB	4.84e-06	2	77	2	26442636
Pubmed	Gradient model describes the spatial-temporal expression pattern of Hoxa genes in the developing vertebrate limb.	HOXA10 HOXA11	4.84e-06	2	77	2	8950520
Pubmed	Characterization of Hoxa-10/Hoxa-11 transheterozygotes reveals functional redundancy and regulatory interactions.	HOXA10 HOXA11	4.84e-06	2	77	2	10926774
Pubmed	Multiple enhancers regulate Hoxd genes and the Hotdog LncRNA during cecum budding.	HOXA10 HOXA11 CD44	6.94e-06	17	77	3	24075990
Pubmed	High-throughput screening of functional deubiquitinating enzymes in autophagy.	USP28 AMBRA1 OTUD7B	8.31e-06	18	77	3	32453962
Pubmed	Familial and hereditary gastric cancer, an overview.	APC CTNNA1	1.45e-05	3	77	2	35988963
Pubmed	Absence of the CD44 gene prevents sarcoma metastasis.	CD44 APC	1.45e-05	3	77	2	11956084
Pubmed	BET protein-dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer.	APC TNKS	1.45e-05	3	77	2	38216082
Pubmed	The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer.	USP28 APC	1.45e-05	3	77	2	24960159
Pubmed	Identification of a Wnt-induced protein complex by affinity proteomics using an antibody that recognizes a sub-population of β-catenin.	APC CTNNA1	1.45e-05	3	77	2	22469663
Pubmed	Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice.	HOXA10 HOXA11	1.45e-05	3	77	2	7700356
Pubmed	Alpha-catenin is essential in intestinal adenoma formation.	APC CTNNA1	1.45e-05	3	77	2	17989230
Pubmed	Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis.	CD44 APC	1.45e-05	3	77	2	18483247
Pubmed	Association of the APC tumor suppressor protein with catenins.	APC CTNNA1	1.45e-05	3	77	2	8259519
Pubmed	Functional comparison of the Hoxa 4, Hoxa 10, and Hoxa 11 homeoboxes.	HOXA10 HOXA11	1.45e-05	3	77	2	11900456
Pubmed	Evolution and expression of chimeric POTE-actin genes in the human genome.	POTEE POTEF	1.45e-05	3	77	2	17101985
Pubmed	Promoter methylation in APC, RUNX3, and GSTP1 and mortality in prostate cancer patients.	APC RUNX3	1.45e-05	3	77	2	19470943
Pubmed	High levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming event.	HOXA10 CD44	1.45e-05	3	77	2	21116281
Pubmed	Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins.	AGO1 AGO4	1.45e-05	3	77	2	19946268
Pubmed	Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway.	CD44 APC	1.45e-05	3	77	2	10027409
Pubmed	Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.	HOXA10 HOXA11 CD44	1.79e-05	23	77	3	16672333
Pubmed	Role of β-catenin in development of bile ducts.	CD44 APC BICC1	1.79e-05	23	77	3	26856660
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SEMA6C ARID1B AGO4 USP28 ANKIB1 AMBRA1 HIC2 CRAMP1	2.28e-05	529	77	8	14621295
Pubmed	Molecular dissection of human Argonaute proteins by DNA shuffling.	AGO1 AGO4	2.89e-05	4	77	2	23748378
Pubmed	Respecification of vertebral identities by retinoic acid.	HOXA10 HOXA11	2.89e-05	4	77	2	1358593
Pubmed	PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression.	HOXA10 APC	2.89e-05	4	77	2	23276799
Pubmed	Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.	AGO1 AGO4	2.89e-05	4	77	2	15260970
Pubmed	HoxA-11 and FOXO1A cooperate to regulate decidual prolactin expression: towards inferring the core transcriptional regulators of decidual genes.	HOXA10 HOXA11	2.89e-05	4	77	2	19727442
Pubmed	A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes.	HOXA10 HOXA11	2.89e-05	4	77	2	9408238
Pubmed	A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias.	HOXA10 HOXA11	2.89e-05	4	77	2	15674412
Pubmed	Usp28 counteracts Fbw7 in intestinal homeostasis and cancer.	USP28 APC	2.89e-05	4	77	2	25716680
Pubmed	Bidirectional transcription from human LRRTM2/CTNNA1 and LRRTM1/CTNNA2 gene loci leads to expression of N-terminally truncated CTNNA1 and CTNNA2 isoforms.	LRRTM1 CTNNA1	2.89e-05	4	77	2	21708131
Pubmed	Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death.	APC TNKS	2.89e-05	4	77	2	30260955
Pubmed	Protein Degradation of RNA Polymerase II-Association Factor 1(PAF1) Is Controlled by CNOT4 and 26S Proteasome.	CTR9 PAF1	2.89e-05	4	77	2	25933433
Pubmed	Slicing-independent RISC activation requires the argonaute PAZ domain.	AGO1 AGO4	2.89e-05	4	77	2	22795694
Pubmed	Analysis of APC, alpha-, beta-catenins, and N-cadherin protein expression in aggressive fibromatosis (desmoid tumor).	APC CTNNA1	2.89e-05	4	77	2	19124205
Pubmed	ATP-dependent human RISC assembly pathways.	AGO1 AGO4	2.89e-05	4	77	2	19966796
Pubmed	The establishment of murine Hox-1 expression domains during patterning of the limb.	HOXA10 HOXA11	2.89e-05	4	77	2	8099045
Pubmed	Importance of translation and nonnucleolytic ago proteins for on-target RNA interference.	AGO1 AGO4	2.89e-05	4	77	2	18771919
Pubmed	A Requirement for Argonaute 4 in Mammalian Antiviral Defense.	AGO1 AGO4	2.89e-05	4	77	2	32049003
Pubmed	Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.	AGO1 AGO4	4.82e-05	5	77	2	12526743
Pubmed	Differential expression of Dicer and Argonaute genes during the differentiation of human neuroblastoma cells.	AGO1 AGO4	4.82e-05	5	77	2	19393748
Pubmed	The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin.	APC CTNNA1	4.82e-05	5	77	2	7651399
Pubmed	CD44s is a crucial ATG7 downstream regulator for stem-like property, invasion, and lung metastasis of human bladder cancer (BC) cells.	USP28 CD44	4.82e-05	5	77	2	30635654
Pubmed	The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin.	APC CTNNA1	4.82e-05	5	77	2	7890674
Pubmed	Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation.	CTR9 PAF1	4.82e-05	5	77	2	26687678
Pubmed	hCTR9, a component of Paf1 complex, participates in the transcription of interleukin 6-responsive genes through regulation of STAT3-DNA interactions.	CTR9 PAF1	4.82e-05	5	77	2	17911113
Pubmed	Differential expression of components of the microRNA machinery during mouse organogenesis.	AGO1 AGO4	4.82e-05	5	77	2	16036130
Pubmed	The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis.	AGO1 AGO4	4.82e-05	5	77	2	12414724
Pubmed	PRC2-Associated Chromatin Contacts in the Developing Limb Reveal a Possible Mechanism for the Atypical Role of PRC2 in HoxA Gene Expression.	HOXA10 HOXA11	4.82e-05	5	77	2	31204170
Pubmed	The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.	AGO1 AGO4	4.82e-05	5	77	2	19324964
Pubmed	Structural basis for evolutionarily conserved interactions between TFIIS and Paf1C.	CTR9 PAF1	4.82e-05	5	77	2	37696373
Pubmed	MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms.	CD44 APC	4.82e-05	5	77	2	28716720
Pubmed	Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer.	LYPD3 CTNNA1	4.82e-05	5	77	2	12477722
Pubmed	LEF1 and B9L shield β-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors.	APC TNKS	4.82e-05	5	77	2	24419084
Pubmed	New and novel intrinsic host repressive factors against HIV-1: PAF1 complex, HERC5 and others.	CTR9 PAF1	7.22e-05	6	77	2	22405323
Pubmed	Wnt-7a maintains appropriate uterine patterning during the development of the mouse female reproductive tract.	HOXA10 HOXA11	7.22e-05	6	77	2	9671592
Pubmed	Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II.	CTR9 PAF1	7.22e-05	6	77	2	18469135
Pubmed	saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription.	CTR9 PAF1	7.22e-05	6	77	2	26902284
Pubmed	Evolution of Hoxa11 regulation in vertebrates is linked to the pentadactyl state.	HOXA10 HOXA11	7.22e-05	6	77	2	27706137
Pubmed	Identification and in vivo role of the Armadillo-Legless interaction.	APC CTNNA1	7.22e-05	6	77	2	15294866
Pubmed	The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis.	CTR9 PAF1	7.22e-05	6	77	2	20541477
Pubmed	The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma.	POTEE FLG EPPK1 POTEF	7.41e-05	100	77	4	21800051
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	LARP4B CTR9 GYG1 ARFGAP1 PER1 TNKS TNRC6C PAF1 PPP6R2 ADD1	9.63e-05	1038	77	10	26673895
Pubmed	Conservation and divergence of regulatory strategies at Hox Loci and the origin of tetrapod digits.	HOXA10 HOXA11	1.01e-04	7	77	2	24465181
Pubmed	Genome-wide identification of microRNA targets reveals positive regulation of the Hippo pathway by miR-122 during liver development.	AGO1 AGO4	1.01e-04	7	77	2	34907157
Pubmed	Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle.	HOXA10 HOXA11	1.01e-04	7	77	2	34108202
Pubmed	RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis.	APC RUNX3	1.01e-04	7	77	2	18772112
Pubmed	The parafibromin tumor suppressor protein is part of a human Paf1 complex.	CTR9 PAF1	1.01e-04	7	77	2	15632063
Pubmed	PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia.	CTR9 PAF1	1.01e-04	7	77	2	29774127
Pubmed	Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.	AGO1 AGO4	1.01e-04	7	77	2	19536157
Pubmed	Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains.	APC OTUD7B	1.01e-04	7	77	2	18281465
Interaction	POTEG interactions	POTEF POTEG POTEH	1.06e-05	12	75	3	int:POTEG
Interaction	POTEH interactions	POTEG POTEH	1.37e-05	2	75	2	int:POTEH
GeneFamily	Ankyrin repeat domain containing\|POTE ankyrin domain containing	POTEE POTEM POTEF POTEG POTEB2 POTEH POTEB	3.13e-15	13	56	7	685
GeneFamily	Ankyrin repeat domain containing	POTEE POTEM POTEF POTEG ANKIB1 TNKS POTEB2 POTEH POTEB	5.21e-08	242	56	9	403
GeneFamily	Tetratricopeptide repeat domain containing\|Paf1/RNA polymerase II complex	CTR9 PAF1	1.40e-04	6	56	2	1029
GeneFamily	EF-hand domain containing\|S100 fused type protein family	FLG CRNN	1.96e-04	7	56	2	1350
GeneFamily	EF-hand domain containing\|Plakins	EPPK1 EVPLL	2.61e-04	8	56	2	939
GeneFamily	Argonaute/PIWI family	AGO1 AGO4	2.61e-04	8	56	2	408
ToppCell	Skin\|World / Skin and Kidney Cells in Lupus Nephritis Patients.	FLG EPPK1 MYCBP2 CD44 LYPD3 GPNMB	1.27e-06	199	77	6	6be1340413ee868c610b6e3f58c65b493eb22bb5
ToppCell	TCGA-Brain-Primary_Tumor-Glioblastoma-Primary_GBM-11\|TCGA-Brain / Sample_Type by Project: Shred V9	POTEE SPAG4 POTEF POTEG	4.37e-06	63	77	4	d7dc1356a60cb527fe668328d5375f352239d911
ToppCell	E15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SEMA6C FAM171A1 TRIL AGO4 GYG1	7.13e-06	154	77	5	e65e4636646164610f33f7bbac0d879a3ea55986
ToppCell	facs-Skin-Skin_Anagen-18m-Mesenchymal-fibroblast\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM171A1 GPNMB APOBR BICC1 SOD3	1.69e-05	184	77	5	fea4fe648e9749177d0783443dc26a7df5807883
ToppCell	facs-Skin-Skin_Anagen-18m-Mesenchymal-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM171A1 GPNMB APOBR BICC1 SOD3	1.69e-05	184	77	5	96a8a0a190bc293655fe7d80cbed8119c0da25f2
ToppCell	facs-Skin-Skin_Anagen-18m-Mesenchymal\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM171A1 GPNMB APOBR BICC1 SOD3	1.69e-05	184	77	5	780eb72da43527f0c72effac3423ec7384f05f20
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-9\|TCGA-Breast / Sample_Type by Project: Shred V9	POTEE POTEM POTEF POTEH	1.81e-05	90	77	4	96e836c7a1df279ac812b7c3aa75e6b81b614244
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	CD44 APC CTNNA1	2.80e-05	26	67	3	C0009405
Disease	Hereditary Nonpolyposis Colorectal Cancer	CD44 APC CTNNA1	3.92e-05	29	67	3	C1333990
Disease	Lynch Syndrome	CD44 APC	1.81e-04	9	67	2	C4552100
Disease	endometrial carcinoma (is_implicated_in)	APC RUNX3	3.30e-04	12	67	2	DOID:2871 (is_implicated_in)
Disease	Contact Dermatitis	FLG CD44 SOD3	5.73e-04	71	67	3	C0011616
Disease	Contact hypersensitivity	FLG CD44 SOD3	5.73e-04	71	67	3	C0162351
Disease	Polyposis, Adenomatous Intestinal	CD44 APC	5.97e-04	16	67	2	C2713442
Disease	Familial Intestinal Polyposis	CD44 APC	5.97e-04	16	67	2	C2713443
Disease	Adenomatous Polyposis Coli	CD44 APC	6.76e-04	17	67	2	C0032580
Disease	Female Urogenital Diseases	HOXA10 HOXA11	7.59e-04	18	67	2	C1720887
Disease	transitional cell carcinoma (is_implicated_in)	CD44 APC	1.14e-03	22	67	2	DOID:2671 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SGRQHASEGDGDQSP	C2orf48	6	Q96LS8
DSDGENGTGQSHHNV	GPNMB	141	Q14956
DSGEGSHISGQSNGR	AGO1	821	Q9UL18
GDSGNEAANRGDGSD	ANKIB1	1056	Q9P2G1
STNRNSNSDGGEGGE	ARFGAP1	371	Q8N6T3
QHGGAKDSAAGGQAD	ARID1B	241	Q8NFD5
GHRGSSGSQVTNSEG	FLG	1386	P20930
NEEQSGDGSRHSGSR	FLG	1546	P20930
TRNEEQSGDGSRHSG	FLG	2841	P20930
SAEGSHVSGQSNGRD	AGO4	826	Q9HCK5
NHLLDGGSSRGDAAG	AMBRA1	1276	Q9C0C7
SNSREHLGGGSESDN	BICC1	801	Q9H694
KNGGAADSGQGHANS	TFAP2D	416	Q7Z6R9
QDNRAHAASSGGRGA	GALNT16	26	Q8N428
GGDNSGTAENGRHSD	R3HDM2	911	Q9Y2K5
RGSGTSNVGTSGDHD	POTEB2	36	H3BUK9
RSHVSSNGGGGGSNE	OTUD7B	111	Q6GQQ9
GKSNVGASGDHDDSA	POTEF	76	A5A3E0
GLDGNGTGNSTRHDL	FAM171A1	186	Q5VUB5
GGSFSRDNGGDAASN	KLHL36	351	Q8N4N3
DDHYSLQSGTGGDSG	MXD4	181	Q14582
GDSDGQQNGHIESEG	GRXCR1	56	A8MXD5
ATTLADGGEGQHDGT	LRRTM1	391	Q86UE6
QGSDANGDGDQGHEN	LARP4B	96	Q92615
GSAGRHGENRGANDG	DDX42	866	Q86XP3
HGENRGANDGRNGES	DDX42	871	Q86XP3
QSPGGHSNSDDVDGN	HMBOX1	356	Q6NT76
SNGGQDGGRQDVHSR	GP6	321	Q9HCN6
GSSGNESNGHESRGA	PER1	51	O15534
HPQSGGQDNDSGSDL	FAM205A	411	Q6ZU69
HPQSGGQDNDSGSDL	FAM205BP	141	Q63HN1
GGTDRGAQHRAEGDQ	EVPLL	131	A8MZ36
GSGGGSQGDEEAHAS	HOXA10	281	P31260
SGHTEDKAGGSSGQR	HOXA11	226	P31270
QTDAANGNSSHGGKG	GREB1L	276	Q9C091
HSGASQELGEGQRSG	CRNN	106	Q9UBG3
AGDHIQSGAGGSDND	ELAPOR2	471	A8MWY0
LTGGAAGHQDRSNSG	LYPD3	296	O95274
GKSNVGASGDHDDSA	POTEE	76	Q6S8J3
SQRHSGQAGTEAGNG	FBXO43	36	Q4G163
RGQAQGGSDNDSDSG	PAF1	471	Q8N7H5
DSDSGSNGGGQRSRS	PAF1	481	Q8N7H5
AGNDSGHGGESNLAL	EEA1	66	Q15075
HLASEQGSFDGGDQG	GYG1	151	P46976
ATASDDASQHQGGGG	CTNNA1	261	P35221
TAGASRSQGGGHEDR	C6orf141	51	Q5SZD1
SESDGHSHGSQEGGA	CD44	621	P16070
SNHAGESFLGSDGDE	CMYA5	6	Q8N3K9
RADEAGSHGNEVGNA	CMYA5	3351	Q8N3K9
GAISGQDSTGTHQDG	CRAMP1	991	Q96RY5
DHESERGSDNEGSGQ	CTR9	1131	Q6PD62
RGSDNEGSGQGSGNE	CTR9	1136	Q6PD62
HGEGRSSTNGNKEGA	KNCN	86	A6PVL3
NGHCSGDGSRQGDGS	CRELD2	151	Q6UXH1
NRQEDTHGSDGDGDG	C4orf19	271	Q8IY42
GGSHSEDGDQKAASA	PPP6R2	826	O75170
SEDSAQSGSEGGSGH	HIC2	406	Q96JB3
LGGQSDGVEADGSHS	RUNX3	381	Q13761
EGGLRASHQQNGDAG	RPUSD2	46	Q8IZ73
GGSSGSKQNSDHSNG	GTF2E2	46	P29084
SEGSSDGSGNHNEGS	TNRC6C	396	Q9HCJ0
DGSGNHNEGSTGREG	TNRC6C	401	Q9HCJ0
SQVHGRGDGSSGGSA	TMEM132E	981	Q6IEE7
RGDGSSGGSARDQAE	TMEM132E	986	Q6IEE7
EAAGNRSNSSGADGG	SLC22A23	166	A1A5C7
RGSGTSNVGTSGDHD	POTEB	36	A0A0A6YYL3
DGDSGRSQREGQGEG	EPPK1	3141	P58107
GDGDSGRSQREGQGE	EPPK1	3671	P58107
DGDSGRSQREGQGEG	EPPK1	4206	P58107
GDGDSGRSQREGQGE	EPPK1	4741	P58107
NDRDQGGGSAGHPAS	MYCBP2	86	O75592
GGRSGAEEASGHRQD	NOM1	111	Q5C9Z4
DASSADGGSGLGSHR	SEBOX	6	Q9HB31
HGVRTSEGAEGSAQG	SPAG4	421	Q9NPE6
GRGDEASEEGQNGSS	ADD1	451	P35611
GANGSETNRVGSNHG	APC	1106	P25054
GSSHGSQAERQDSGA	APOBR	106	Q0VD83
GNGSVGDNALRHDND	ZNF157	106	P51786
SSSQNGHEEGATGDR	RIPOR3	491	Q96MK2
EGNHRAADSQNSGEG	TPR	2026	P12270
HAGEDDLGRGGNQAS	SOD3	181	P08294
QSTIREHRDGGNAGG	TNKS	1126	O95271
SSNGENVHLGSGDGQ	ZNF410	191	Q86VK4
GTEHQERAAQSDGGA	TRIL	556	Q7L0X0
EHGDCQDGATGSQSG	SEMA6C	566	Q9H3T2
QQDDAAGAADGHGSS	USP28	6	Q96RU2
NGDSGEGFSQGSHLQ	ZNF233	316	A6NK53
RGSGKSNVGTSGDHD	POTEG	36	Q6S5H5
RGSGKSNVGTSGDHD	POTEH	36	Q6S545
RGSGKSNVGTSGDHD	POTEM	36	A6NI47
HAQDAGETAAGGGER	TUB	161	P50607
GGSGSRQGRQDGDQD	UBQLN3	311	Q9H347